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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for SWAP70 |
 Gene summary |
| Gene information | Gene symbol | SWAP70 | Gene ID | 23075 |
| Gene name | switching B cell complex subunit SWAP70 | |
| Synonyms | HSPC321|SWAP-70 | |
| Cytomap | 11p15.4 | |
| Type of gene | protein-coding | |
| Description | switch-associated protein 70SWAP switching B-cell complex 70kDa subunitSWAP switching B-cell complex subunit 70 | |
| Modification date | 20200313 | |
| UniProtAcc | Q9UH65, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for SWAP70 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_292936(9669942, +), ADediting_292937(9669949, +), ADediting_292938(9674163, +), ADediting_292939(9683145, +), ADediting_292940(9683341, +), ADediting_292941(9683403, +), ADediting_292942(9695108, +), ADediting_292943(9695113, +), ADediting_292944(9695214, +), ADediting_292945(9695249, +), ADediting_292946(9699709, +), ADediting_292947(9704628, +), ADediting_292948(9718969, +), ADediting_292949(9729694, +), ADediting_292950(9729714, +), ADediting_292951(9737802, +), ADediting_292952(9741989, +), ADediting_292953(9741994, +), ADediting_292954(9742059, +), ADediting_292955(9742437, +), ADediting_292956(9742520, +), ADediting_292957(9744043, +), ADediting_292958(9744147, +), ADediting_292959(9744161, +), ADediting_292960(9744169, +), ADediting_292961(9744653, +), ADediting_292962(9744661, +), ADediting_292963(9744732, +), ADediting_292964(9744743, +), ADediting_292965(9744746, +), ADediting_292966(9744747, +), ADediting_292967(9744749, +), ADediting_292968(9744750, +), ADediting_292969(9744752, +), ADediting_292970(9744761, +), ADediting_292971(9744779, +), ADediting_292972(9744785, +), ADediting_292973(9744787, +), ADediting_292974(9744788, +), ADediting_292975(9744797, +), ADediting_292976(9744824, +), ADediting_292977(9749327, +), ADediting_292978(9749376, +), ADediting_292979(9750083, +), ADediting_292980(9750151, +), ADediting_292981(9750152, +), ADediting_292982(9750162, +), ADediting_292983(9750194, +), ADediting_292984(9750220, +), ADediting_292985(9750221, +), ADediting_292986(9750226, +), ADediting_292987(9750230, +), ADediting_292988(9750293, +), ADediting_1611443(9669450, +), |
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RNA editing positional annotations for SWAP70 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_292936 | chr11_9669942_+ | intronic |
| ADediting_292937 | chr11_9669949_+ | intronic |
| ADediting_292938 | chr11_9674163_+ | intronic |
| ADediting_292939 | chr11_9683145_+ | intronic |
| ADediting_292940 | chr11_9683341_+ | intronic |
| ADediting_292941 | chr11_9683403_+ | intronic |
| ADediting_292942 | chr11_9695108_+ | intronic |
| ADediting_292943 | chr11_9695113_+ | intronic |
| ADediting_292944 | chr11_9695214_+ | intronic |
| ADediting_292945 | chr11_9695249_+ | intronic |
| ADediting_292946 | chr11_9699709_+ | intronic |
| ADediting_292947 | chr11_9704628_+ | intronic |
| ADediting_292948 | chr11_9718969_+ | intronic |
| ADediting_292949 | chr11_9729694_+ | intronic |
| ADediting_292950 | chr11_9729714_+ | intronic |
| ADediting_292951 | chr11_9737802_+ | intronic |
| ADediting_292952 | chr11_9741989_+ | intronic |
| ADediting_292953 | chr11_9741994_+ | intronic |
| ADediting_292954 | chr11_9742059_+ | intronic |
| ADediting_292955 | chr11_9742437_+ | intronic |
| ADediting_292956 | chr11_9742520_+ | intronic |
| ADediting_292957 | chr11_9744043_+ | intronic |
| ADediting_292958 | chr11_9744147_+ | intronic |
| ADediting_292959 | chr11_9744161_+ | intronic |
| ADediting_292960 | chr11_9744169_+ | intronic |
| ADediting_292961 | chr11_9744653_+ | intronic |
| ADediting_292962 | chr11_9744661_+ | intronic |
| ADediting_292963 | chr11_9744732_+ | intronic |
| ADediting_292964 | chr11_9744743_+ | intronic |
| ADediting_292965 | chr11_9744746_+ | intronic |
| ADediting_292966 | chr11_9744747_+ | intronic |
| ADediting_292967 | chr11_9744749_+ | intronic |
| ADediting_292968 | chr11_9744750_+ | intronic |
| ADediting_292969 | chr11_9744752_+ | intronic |
| ADediting_292970 | chr11_9744761_+ | intronic |
| ADediting_292971 | chr11_9744779_+ | intronic |
| ADediting_292972 | chr11_9744785_+ | intronic |
| ADediting_292973 | chr11_9744787_+ | intronic |
| ADediting_292974 | chr11_9744788_+ | intronic |
| ADediting_292975 | chr11_9744797_+ | intronic |
| ADediting_292976 | chr11_9744824_+ | intronic |
| ADediting_292977 | chr11_9749327_+ | intronic |
| ADediting_292978 | chr11_9749376_+ | intronic |
| ADediting_292979 | chr11_9750083_+ | UTR3 |
| ADediting_292980 | chr11_9750151_+ | UTR3 |
| ADediting_292981 | chr11_9750152_+ | UTR3 |
| ADediting_292982 | chr11_9750162_+ | UTR3 |
| ADediting_292983 | chr11_9750194_+ | UTR3 |
| ADediting_292984 | chr11_9750220_+ | UTR3 |
| ADediting_292985 | chr11_9750221_+ | UTR3 |
| ADediting_292986 | chr11_9750226_+ | UTR3 |
| ADediting_292987 | chr11_9750230_+ | UTR3 |
| ADediting_292988 | chr11_9750293_+ | UTR3 |
| ADediting_1611443 | chr11_9669450_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_292936 | chr11_9669942_+ | SINE | Alu | Name=AluSx |
| ADediting_292937 | chr11_9669949_+ | SINE | Alu | Name=AluSx |
| ADediting_292938 | chr11_9674163_+ | SINE | Alu | Name=AluSz |
| ADediting_292939 | chr11_9683145_+ | SINE | Alu | Name=AluJb |
| ADediting_292940 | chr11_9683341_+ | SINE | Alu | Name=AluJb |
| ADediting_292941 | chr11_9683403_+ | SINE | Alu | Name=AluJb |
| ADediting_292942 | chr11_9695108_+ | SINE | Alu | Name=AluSq2 |
| ADediting_292943 | chr11_9695113_+ | SINE | Alu | Name=AluSq2 |
| ADediting_292944 | chr11_9695214_+ | SINE | Alu | Name=AluSq2 |
| ADediting_292945 | chr11_9695249_+ | SINE | Alu | Name=AluSq2 |
| ADediting_292946 | chr11_9699709_+ | SINE | Alu | Name=AluJr4 |
| ADediting_292947 | chr11_9704628_+ | SINE | Alu | Name=AluSz |
| ADediting_292948 | chr11_9718969_+ | SINE | Alu | Name=AluJb |
| ADediting_292949 | chr11_9729694_+ | SINE | Alu | Name=AluSx3 |
| ADediting_292950 | chr11_9729714_+ | SINE | Alu | Name=AluSx3 |
| ADediting_292951 | chr11_9737802_+ | SINE | Alu | Name=AluSc |
| ADediting_292952 | chr11_9741989_+ | SINE | Alu | Name=AluJb |
| ADediting_292953 | chr11_9741994_+ | SINE | Alu | Name=AluJb |
| ADediting_292954 | chr11_9742059_+ | SINE | Alu | Name=AluJb |
| ADediting_292955 | chr11_9742437_+ | SINE | Alu | Name=AluSc |
| ADediting_292956 | chr11_9742520_+ | SINE | Alu | Name=AluSc |
| ADediting_292957 | chr11_9744043_+ | SINE | Alu | Name=AluYm1 |
| ADediting_292958 | chr11_9744147_+ | SINE | Alu | Name=AluYm1 |
| ADediting_292959 | chr11_9744161_+ | SINE | Alu | Name=AluYm1 |
| ADediting_292960 | chr11_9744169_+ | SINE | Alu | Name=AluYm1 |
| ADediting_292961 | chr11_9744653_+ | SINE | Alu | Name=AluSz |
| ADediting_292962 | chr11_9744661_+ | SINE | Alu | Name=AluSz |
| ADediting_292963 | chr11_9744732_+ | SINE | Alu | Name=AluSz |
| ADediting_292964 | chr11_9744743_+ | SINE | Alu | Name=AluSz |
| ADediting_292965 | chr11_9744746_+ | SINE | Alu | Name=AluSz |
| ADediting_292966 | chr11_9744747_+ | SINE | Alu | Name=AluSz |
| ADediting_292967 | chr11_9744749_+ | SINE | Alu | Name=AluSz |
| ADediting_292968 | chr11_9744750_+ | SINE | Alu | Name=AluSz |
| ADediting_292969 | chr11_9744752_+ | SINE | Alu | Name=AluSz |
| ADediting_292970 | chr11_9744761_+ | SINE | Alu | Name=AluSz |
| ADediting_292971 | chr11_9744779_+ | SINE | Alu | Name=AluSz |
| ADediting_292972 | chr11_9744785_+ | SINE | Alu | Name=AluSz |
| ADediting_292973 | chr11_9744787_+ | SINE | Alu | Name=AluSz |
| ADediting_292974 | chr11_9744788_+ | SINE | Alu | Name=AluSz |
| ADediting_292975 | chr11_9744797_+ | SINE | Alu | Name=AluSz |
| ADediting_292976 | chr11_9744824_+ | SINE | Alu | Name=AluSz |
| ADediting_292977 | chr11_9749327_+ | SINE | Alu | Name=AluY |
| ADediting_292978 | chr11_9749376_+ | SINE | Alu | Name=AluY |
| ADediting_292979 | chr11_9750083_+ | SINE | Alu | Name=AluSx1 |
| ADediting_292980 | chr11_9750151_+ | SINE | Alu | Name=AluSx1 |
| ADediting_292981 | chr11_9750152_+ | SINE | Alu | Name=AluSx1 |
| ADediting_292982 | chr11_9750162_+ | SINE | Alu | Name=AluSx1 |
| ADediting_292983 | chr11_9750194_+ | SINE | Alu | Name=AluSx1 |
| ADediting_292984 | chr11_9750220_+ | SINE | Alu | Name=AluSx1 |
| ADediting_292985 | chr11_9750221_+ | SINE | Alu | Name=AluSx1 |
| ADediting_292986 | chr11_9750226_+ | SINE | Alu | Name=AluSx1 |
| ADediting_292987 | chr11_9750230_+ | SINE | Alu | Name=AluSx1 |
| ADediting_292988 | chr11_9750293_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1611443 | chr11_9669450_+ | SINE | Alu | Name=AluSz |
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RNA A-to-I editing events in the alternative splicing sites for SWAP70 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SWAP70 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for SWAP70 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for SWAP70 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_292979 | chr11_9750083_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-8052 | chr11 | 9750081 | 9750087 | 7mer-1a | 9750069 | 9750087 | 140 | -24.15 |
| ADediting_292979 | chr11_9750083_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-8052 | chr11 | 9750081 | 9750087 | 7mer-1a | 9750069 | 9750087 | 140 | -24.15 |
| ADediting_292981 | chr11_9750152_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-3190-5p | chr11 | 9750145 | 9750151 | 7mer-m8 | 9750133 | 9750152 | 149 | -18 |
| ADediting_292981 | chr11_9750152_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-3190-5p | chr11 | 9750145 | 9750151 | 7mer-m8 | 9750133 | 9750152 | 149 | -18 |
| ADediting_292982 | chr11_9750162_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-3158-3p | chr11 | 9750159 | 9750165 | 7mer-m8 | 9750145 | 9750166 | 148 | -18.55 |
| ADediting_292982 | chr11_9750162_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-6754-3p | chr11 | 9750155 | 9750161 | 7mer-m8 | 9750142 | 9750162 | 146 | -15.4 |
| ADediting_292982 | chr11_9750162_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-3158-3p | chr11 | 9750159 | 9750165 | 7mer-m8 | 9750145 | 9750166 | 148 | -18.55 |
| ADediting_292982 | chr11_9750162_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-6754-3p | chr11 | 9750155 | 9750161 | 7mer-m8 | 9750142 | 9750162 | 146 | -15.4 |
| ADediting_292983 | chr11_9750194_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-3157-5p | chr11 | 9750192 | 9750198 | 7mer-m8 | 9750178 | 9750199 | 141 | -15.65 |
| ADediting_292983 | chr11_9750194_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-3157-5p | chr11 | 9750192 | 9750198 | 7mer-m8 | 9750178 | 9750199 | 141 | -15.65 |
| ADediting_292984 | chr11_9750220_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-513a-5p | chr11 | 9750214 | 9750220 | 7mer-m8 | 9750204 | 9750221 | 140 | -18.01 |
| ADediting_292984 | chr11_9750220_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-638 | chr11 | 9750219 | 9750225 | 7mer-1a | 9750201 | 9750225 | 155 | -34.54 |
| ADediting_292984 | chr11_9750220_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-513a-5p | chr11 | 9750214 | 9750220 | 7mer-m8 | 9750204 | 9750221 | 140 | -18.01 |
| ADediting_292984 | chr11_9750220_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-638 | chr11 | 9750219 | 9750225 | 7mer-1a | 9750201 | 9750225 | 155 | -34.54 |
| ADediting_292985 | chr11_9750221_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-8052 | chr11 | 9750219 | 9750225 | 7mer-1a | 9750205 | 9750225 | 141 | -23.11 |
| ADediting_292985 | chr11_9750221_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-8052 | chr11 | 9750219 | 9750225 | 7mer-1a | 9750205 | 9750225 | 141 | -23.11 |
| ADediting_292987 | chr11_9750230_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-1207-3p | chr11 | 9750223 | 9750229 | 7mer-m8 | 9750213 | 9750230 | 140 | -12.56 |
| ADediting_292987 | chr11_9750230_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-646 | chr11 | 9750225 | 9750231 | 7mer-m8 | 9750214 | 9750232 | 145 | -16.24 |
| ADediting_292987 | chr11_9750230_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-1207-3p | chr11 | 9750223 | 9750229 | 7mer-m8 | 9750213 | 9750230 | 140 | -12.56 |
| ADediting_292987 | chr11_9750230_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-646 | chr11 | 9750225 | 9750231 | 7mer-m8 | 9750214 | 9750232 | 145 | -16.24 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_292979 | chr11_9750083_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-10399-5p | chr11 | 9750077 | 9750083 | 7mer-m8 | 9750063 | 9750084 | 144 | -10.39 |
| ADediting_292979 | chr11_9750083_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-5089-5p | chr11 | 9750081 | 9750087 | 7mer-m8 | 9750066 | 9750088 | 148 | -14.13 |
| ADediting_292979 | chr11_9750083_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-6504-3p | chr11 | 9750077 | 9750083 | 7mer-m8 | 9750063 | 9750084 | 148 | -14.48 |
| ADediting_292979 | chr11_9750083_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-10399-5p | chr11 | 9750077 | 9750083 | 7mer-m8 | 9750063 | 9750084 | 144 | -10.39 |
| ADediting_292979 | chr11_9750083_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-5089-5p | chr11 | 9750081 | 9750087 | 7mer-m8 | 9750066 | 9750088 | 148 | -14.13 |
| ADediting_292979 | chr11_9750083_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-6504-3p | chr11 | 9750077 | 9750083 | 7mer-m8 | 9750063 | 9750084 | 148 | -14.48 |
| ADediting_292980 | chr11_9750151_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-4435 | chr11 | 9750144 | 9750151 | 8mer-1a | 9750131 | 9750151 | 146 | -18.22 |
| ADediting_292980 | chr11_9750151_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-4435 | chr11 | 9750144 | 9750151 | 8mer-1a | 9750131 | 9750151 | 146 | -18.22 |
| ADediting_292982 | chr11_9750162_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-6823-5p | chr11 | 9750160 | 9750166 | 7mer-m8 | 9750147 | 9750167 | 151 | -20.84 |
| ADediting_292982 | chr11_9750162_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-6823-5p | chr11 | 9750160 | 9750166 | 7mer-m8 | 9750147 | 9750167 | 151 | -20.84 |
| ADediting_292983 | chr11_9750194_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-4735-5p | chr11 | 9750188 | 9750194 | 7mer-m8 | 9750174 | 9750195 | 140 | -4.28 |
| ADediting_292983 | chr11_9750194_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-4775 | chr11 | 9750187 | 9750193 | 7mer-m8 | 9750173 | 9750194 | 154 | -5.78 |
| ADediting_292983 | chr11_9750194_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-4735-5p | chr11 | 9750188 | 9750194 | 7mer-m8 | 9750174 | 9750195 | 140 | -4.28 |
| ADediting_292983 | chr11_9750194_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-4775 | chr11 | 9750187 | 9750193 | 7mer-m8 | 9750173 | 9750194 | 154 | -5.78 |
| ADediting_292984 | chr11_9750220_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-10399-5p | chr11 | 9750215 | 9750221 | 7mer-m8 | 9750203 | 9750222 | 141 | -12.5 |
| ADediting_292984 | chr11_9750220_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-6504-3p | chr11 | 9750215 | 9750221 | 7mer-m8 | 9750201 | 9750222 | 148 | -14.75 |
| ADediting_292984 | chr11_9750220_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-7151-3p | chr11 | 9750213 | 9750220 | 8mer-1a | 9750200 | 9750220 | 140 | -12.68 |
| ADediting_292984 | chr11_9750220_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-10399-5p | chr11 | 9750215 | 9750221 | 7mer-m8 | 9750203 | 9750222 | 141 | -12.5 |
| ADediting_292984 | chr11_9750220_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-6504-3p | chr11 | 9750215 | 9750221 | 7mer-m8 | 9750201 | 9750222 | 148 | -14.75 |
| ADediting_292984 | chr11_9750220_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-7151-3p | chr11 | 9750213 | 9750220 | 8mer-1a | 9750200 | 9750220 | 140 | -12.68 |
| ADediting_292985 | chr11_9750221_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-10399-5p | chr11 | 9750215 | 9750221 | 7mer-m8 | 9750203 | 9750222 | 141 | -12.5 |
| ADediting_292985 | chr11_9750221_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-5089-5p | chr11 | 9750219 | 9750225 | 7mer-m8 | 9750206 | 9750226 | 144 | -13.27 |
| ADediting_292985 | chr11_9750221_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-6504-3p | chr11 | 9750215 | 9750221 | 7mer-m8 | 9750201 | 9750222 | 148 | -14.75 |
| ADediting_292985 | chr11_9750221_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-10399-5p | chr11 | 9750215 | 9750221 | 7mer-m8 | 9750203 | 9750222 | 141 | -12.5 |
| ADediting_292985 | chr11_9750221_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-5089-5p | chr11 | 9750219 | 9750225 | 7mer-m8 | 9750206 | 9750226 | 144 | -13.27 |
| ADediting_292985 | chr11_9750221_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-6504-3p | chr11 | 9750215 | 9750221 | 7mer-m8 | 9750201 | 9750222 | 148 | -14.75 |
| ADediting_292986 | chr11_9750226_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-5089-5p | chr11 | 9750219 | 9750225 | 7mer-m8 | 9750206 | 9750226 | 144 | -13.27 |
| ADediting_292986 | chr11_9750226_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-6506-5p | chr11 | 9750220 | 9750226 | 7mer-m8 | 9750205 | 9750227 | 144 | -15.62 |
| ADediting_292986 | chr11_9750226_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-5089-5p | chr11 | 9750219 | 9750225 | 7mer-m8 | 9750206 | 9750226 | 144 | -13.27 |
| ADediting_292986 | chr11_9750226_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-6506-5p | chr11 | 9750220 | 9750226 | 7mer-m8 | 9750205 | 9750227 | 144 | -15.62 |
| ADediting_292987 | chr11_9750230_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-562 | chr11 | 9750226 | 9750232 | 7mer-m8 | 9750214 | 9750233 | 150 | -12.74 |
| ADediting_292987 | chr11_9750230_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-5697 | chr11 | 9750227 | 9750233 | 7mer-m8 | 9750212 | 9750234 | 149 | -18.32 |
| ADediting_292987 | chr11_9750230_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-562 | chr11 | 9750226 | 9750232 | 7mer-m8 | 9750214 | 9750233 | 150 | -12.74 |
| ADediting_292987 | chr11_9750230_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-5697 | chr11 | 9750227 | 9750233 | 7mer-m8 | 9750212 | 9750234 | 149 | -18.32 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-589-3p | chr11 | 9750784 | 9750791 | 8mer-1a | 9750766 | 9750791 | 147 | -18.31 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-589-3p | chr11 | 9750784 | 9750791 | 8mer-1a | 9750766 | 9750791 | 147 | -18.31 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-4477b | chr11 | 9750887 | 9750893 | 7mer-m8 | 9750873 | 9750894 | 143 | -9.57 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-4477b | chr11 | 9750887 | 9750893 | 7mer-m8 | 9750873 | 9750894 | 143 | -9.57 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-337-3p | chr11 | 9752722 | 9752729 | 8mer-1a | 9752707 | 9752729 | 153 | -14.28 |
| ADediting_1596844 | chr1_162342605_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-556-3p | chr11 | 9752480 | 9752486 | 7mer-m8 | 9752466 | 9752487 | 147 | -14.39 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-641 | chr11 | 9752223 | 9752229 | 7mer-m8 | 9752205 | 9752230 | 146 | -17.97 |
| ADediting_291761 | chr11_93733708_- | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-1304-3p | chr11 | 9750280 | 9750286 | 7mer-m8 | 9750266 | 9750287 | 167 | -30.9 |
| ADediting_291761 | chr11_93733708_- | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-1304-3p | chr11 | 9750280 | 9750286 | 7mer-m8 | 9750266 | 9750287 | 167 | -30.9 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-4477b | chr11 | 9752695 | 9752701 | 7mer-m8 | 9752677 | 9752702 | 152 | -17.15 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-4477b | chr11 | 9752695 | 9752701 | 7mer-m8 | 9752677 | 9752702 | 152 | -17.15 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000133789.15 | ENST00000318950.11 | SWAP70-201 | hsa-miR-4775 | chr11 | 9750187 | 9750193 | 7mer-m8 | 9750173 | 9750194 | 154 | -5.78 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000133789.15 | ENST00000447399.6 | SWAP70-202 | hsa-miR-4775 | chr11 | 9750187 | 9750193 | 7mer-m8 | 9750173 | 9750194 | 154 | -5.78 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for SWAP70 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000447399.6 | protein_coding |  |  |
| ENST00000318950.11 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_292979 | ENST00000447399.6 | chr11_9750083_+ | 1800 | -1063.20 | -1062.50 | -1071.50 |
| ADediting_292980 | ENST00000447399.6 | chr11_9750151_+ | 1868 | -1064.90 | -1062.50 | -1071.50 |
| ADediting_292981 | ENST00000447399.6 | chr11_9750152_+ | 1869 | -1066.20 | -1062.50 | -1071.50 |
| ADediting_292982 | ENST00000447399.6 | chr11_9750162_+ | 1879 | -1063.50 | -1062.50 | -1071.50 |
| ADediting_292983 | ENST00000447399.6 | chr11_9750194_+ | 1911 | -1063.70 | -1062.50 | -1071.50 |
| ADediting_292984 | ENST00000447399.6 | chr11_9750220_+ | 1937 | -1062.50 | -1062.50 | -1071.50 |
| ADediting_292985 | ENST00000447399.6 | chr11_9750221_+ | 1938 | -1062.50 | -1062.50 | -1071.50 |
| ADediting_292986 | ENST00000447399.6 | chr11_9750226_+ | 1943 | -1061.70 | -1062.50 | -1071.50 |
| ADediting_292987 | ENST00000447399.6 | chr11_9750230_+ | 1947 | -1062.50 | -1062.50 | -1071.50 |
| ADediting_292988 | ENST00000447399.6 | chr11_9750293_+ | 2010 | -1062.50 | -1062.50 | -1071.50 |
| ADediting_292979 | ENST00000318950.11 | chr11_9750083_+ | 1974 | -1423.60 | -1422.90 | -1431.90 |
| ADediting_292980 | ENST00000318950.11 | chr11_9750151_+ | 2042 | -1425.30 | -1422.90 | -1431.90 |
| ADediting_292981 | ENST00000318950.11 | chr11_9750152_+ | 2043 | -1426.60 | -1422.90 | -1431.90 |
| ADediting_292982 | ENST00000318950.11 | chr11_9750162_+ | 2053 | -1423.90 | -1422.90 | -1431.90 |
| ADediting_292983 | ENST00000318950.11 | chr11_9750194_+ | 2085 | -1424.10 | -1422.90 | -1431.90 |
| ADediting_292984 | ENST00000318950.11 | chr11_9750220_+ | 2111 | -1422.90 | -1422.90 | -1431.90 |
| ADediting_292985 | ENST00000318950.11 | chr11_9750221_+ | 2112 | -1422.90 | -1422.90 | -1431.90 |
| ADediting_292986 | ENST00000318950.11 | chr11_9750226_+ | 2117 | -1422.10 | -1422.90 | -1431.90 |
| ADediting_292987 | ENST00000318950.11 | chr11_9750230_+ | 2121 | -1422.90 | -1422.90 | -1431.90 |
| ADediting_292988 | ENST00000318950.11 | chr11_9750293_+ | 2184 | -1422.90 | -1422.90 | -1431.90 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for SWAP70 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 7.47580508640511e-17 | 0.44989024718687 | 4.22455796464191e-05 | 0.230366461314776 | 4.49850034216819e-18 | 0.465464714397495 |
| AC | 6.76075887391074e-44 | 0.735936595175836 | 3.10820617956757e-23 | 0.573189369330059 | 1.15547649235635e-22 | 0.566971285978684 |
| PCC | 9.63870837457709e-05 | 0.278387894420969 | 0.00028823872496638 | 0.259536444119955 | 1.75928853942995e-05 | 0.305220110952215 |
| CER | 5.03637225355382e-10 | 0.480174337378678 | 3.08560692278125e-06 | 0.370362697975954 | 2.51988611139453e-11 | 0.510399728433719 |
| TCX | 1.32358585517925e-07 | 0.414663313474102 | 0.686015062917101 | -0.0332776472634032 | 2.93920992683417e-11 | 0.508916339228591 |
| FP | 5.71732476000001e-08 | 0.393077006483072 | 0.00948613876631403 | 0.193946581090841 | 2.15520088511153e-12 | 0.495025892427767 |
| IFG | 0.000549271872734227 | 0.641418994200426 | 0.000799124050761606 | 0.626844701550848 | 0.00394693834696048 | 0.555435861394377 |
| PG | 2.64454569296649e-25 | 0.667026300888654 | 3.89567936693151e-11 | 0.460167919974193 | 0.0469558073071971 | 0.145875023504757 |
| STG | 0.00250505505123409 | 0.325646611256298 | 0.18344415192441 | 0.14655033884459 | 6.36401818260166e-05 | 0.422067831948881 |
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Relation with AD stages for SWAP70 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| IFG | ADediting_292985 | chr11_9750221_+ | 0.0307788525121909 | 0.432613531179913 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 8.626502490566e-05 | 0.368698049494116 |
| TCX | 3.59834546444435e-11 | 0.587475001323706 |
| PG | 2.39105381034055e-06 | 0.337930467125128 |
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RelatedDrugs for SWAP70 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SWAP70 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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