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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for DENND3 |
 Gene summary |
| Gene information | Gene symbol | DENND3 | Gene ID | 22898 |
| Gene name | DENN domain containing 3 | |
| Synonyms | - | |
| Cytomap | 8q24.3 | |
| Type of gene | protein-coding | |
| Description | DENN domain-containing protein 3DENN/MADD domain containing 3 | |
| Modification date | 20200313 | |
| UniProtAcc | A2RUS2, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for DENND3 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_1391933(141138566, +), ADediting_1391934(141138586, +), ADediting_1391935(141138608, +), ADediting_1391936(141141787, +), ADediting_1391937(141141788, +), ADediting_1391938(141141804, +), ADediting_1391939(141141809, +), ADediting_1391940(141141810, +), ADediting_1391941(141141812, +), ADediting_1391942(141141828, +), ADediting_1391943(141141833, +), ADediting_1391944(141141847, +), ADediting_1391945(141141852, +), ADediting_1391946(141141861, +), ADediting_1391947(141141864, +), ADediting_1391948(141141890, +), ADediting_1391949(141141891, +), ADediting_1391950(141141892, +), ADediting_1391951(141141893, +), ADediting_1391952(141141894, +), ADediting_1391953(141141897, +), ADediting_1391954(141141905, +), ADediting_1391955(141141923, +), ADediting_1391956(141141945, +), ADediting_1391957(141141963, +), ADediting_1391958(141141964, +), ADediting_1391959(141141977, +), ADediting_1391960(141141978, +), ADediting_1391961(141141985, +), ADediting_1391962(141142001, +), ADediting_1391963(141142007, +), ADediting_1391964(141142019, +), ADediting_1391965(141143431, +), ADediting_1391966(141143460, +), ADediting_1391967(141143479, +), ADediting_1391968(141143484, +), ADediting_1391969(141143490, +), ADediting_1391970(141143491, +), ADediting_1391971(141143492, +), ADediting_1391972(141143505, +), ADediting_1391973(141143534, +), ADediting_1391974(141143544, +), ADediting_1391975(141143562, +), ADediting_1391976(141143570, +), ADediting_1391977(141143571, +), ADediting_1391978(141143577, +), ADediting_1391979(141143606, +), ADediting_1391980(141143615, +), ADediting_1391981(141143640, +), ADediting_1391982(141143641, +), ADediting_1391983(141143680, +), ADediting_1391984(141161852, +), ADediting_1391985(141161895, +), ADediting_1391986(141161901, +), ADediting_1391987(141161904, +), ADediting_1391988(141161905, +), ADediting_1391989(141161965, +), ADediting_1391990(141162019, +), ADediting_1391991(141162039, +), ADediting_1391992(141162689, +), ADediting_1391993(141162738, +), ADediting_1391994(141162743, +), ADediting_1391995(141162749, +), ADediting_1391996(141162820, +), ADediting_1391997(141162822, +), ADediting_1391998(141162823, +), ADediting_1391999(141162829, +), ADediting_1392000(141162901, +), ADediting_1392001(141168567, +), ADediting_1392002(141168569, +), ADediting_1392003(141168626, +), ADediting_1392004(141172818, +), ADediting_1392005(141172831, +), ADediting_1392006(141172836, +), ADediting_1392007(141172860, +), ADediting_1392008(141181795, +), ADediting_1392009(141185570, +), ADediting_1392010(141185639, +), ADediting_1392011(141185640, +), ADediting_1392012(141185642, +), ADediting_1392013(141185644, +), ADediting_1392014(141185661, +), ADediting_1392015(141185666, +), ADediting_1392016(141185670, +), ADediting_1392017(141185705, +), ADediting_1392018(141185723, +), ADediting_1392019(141185745, +), ADediting_1392020(141185775, +), ADediting_1392021(141185807, +), ADediting_1392022(141185966, +), ADediting_1392023(141186006, +), ADediting_1392024(141186043, +), ADediting_1392025(141186051, +), ADediting_1392026(141186068, +), ADediting_1392027(141186069, +), ADediting_1392028(141186078, +), ADediting_1392029(141186080, +), ADediting_1392030(141186104, +), ADediting_1392031(141186121, +), ADediting_1392032(141186128, +), ADediting_1392033(141186187, +), ADediting_1392034(141187316, +), ADediting_1392035(141187318, +), ADediting_1392036(141187319, +), ADediting_1392037(141187352, +), ADediting_1392038(141187366, +), ADediting_1392039(141187382, +), ADediting_1392040(141187390, +), ADediting_1392041(141187408, +), ADediting_1392042(141187445, +), ADediting_1392043(141187446, +), ADediting_1392044(141187459, +), ADediting_1392045(141187460, +), ADediting_1392046(141187463, +), ADediting_1392047(141187488, +), ADediting_1392048(141187500, +), ADediting_1392049(141187931, +), ADediting_1392050(141187955, +), ADediting_1392051(141187958, +), ADediting_1392052(141187986, +), ADediting_1392053(141187991, +), ADediting_1392054(141188001, +), ADediting_1392055(141188022, +), ADediting_1392056(141188025, +), ADediting_1392057(141188026, +), ADediting_1392058(141188045, +), ADediting_1392059(141188064, +), ADediting_1392060(141188083, +), ADediting_1392061(141188129, +), ADediting_1392062(141188180, +), ADediting_1589913(141185586, +), ADediting_1589914(141185679, +), ADediting_1589915(141187334, +), ADediting_1668746(141161988, +), |
Top |
RNA editing positional annotations for DENND3 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1391933 | chr8_141138566_+ | intronic |
| ADediting_1391934 | chr8_141138586_+ | intronic |
| ADediting_1391935 | chr8_141138608_+ | intronic |
| ADediting_1391936 | chr8_141141787_+ | UTR3 |
| ADediting_1391937 | chr8_141141788_+ | UTR3 |
| ADediting_1391938 | chr8_141141804_+ | UTR3 |
| ADediting_1391939 | chr8_141141809_+ | UTR3 |
| ADediting_1391940 | chr8_141141810_+ | UTR3 |
| ADediting_1391941 | chr8_141141812_+ | UTR3 |
| ADediting_1391942 | chr8_141141828_+ | UTR3 |
| ADediting_1391943 | chr8_141141833_+ | UTR3 |
| ADediting_1391944 | chr8_141141847_+ | UTR3 |
| ADediting_1391945 | chr8_141141852_+ | UTR3 |
| ADediting_1391946 | chr8_141141861_+ | UTR3 |
| ADediting_1391947 | chr8_141141864_+ | UTR3 |
| ADediting_1391948 | chr8_141141890_+ | UTR3 |
| ADediting_1391949 | chr8_141141891_+ | UTR3 |
| ADediting_1391950 | chr8_141141892_+ | UTR3 |
| ADediting_1391951 | chr8_141141893_+ | UTR3 |
| ADediting_1391952 | chr8_141141894_+ | UTR3 |
| ADediting_1391953 | chr8_141141897_+ | UTR3 |
| ADediting_1391954 | chr8_141141905_+ | UTR3 |
| ADediting_1391955 | chr8_141141923_+ | UTR3 |
| ADediting_1391956 | chr8_141141945_+ | UTR3 |
| ADediting_1391957 | chr8_141141963_+ | UTR3 |
| ADediting_1391958 | chr8_141141964_+ | UTR3 |
| ADediting_1391959 | chr8_141141977_+ | UTR3 |
| ADediting_1391960 | chr8_141141978_+ | UTR3 |
| ADediting_1391961 | chr8_141141985_+ | UTR3 |
| ADediting_1391962 | chr8_141142001_+ | UTR3 |
| ADediting_1391963 | chr8_141142007_+ | UTR3 |
| ADediting_1391964 | chr8_141142019_+ | UTR3 |
| ADediting_1391965 | chr8_141143431_+ | intronic |
| ADediting_1391966 | chr8_141143460_+ | intronic |
| ADediting_1391967 | chr8_141143479_+ | intronic |
| ADediting_1391968 | chr8_141143484_+ | intronic |
| ADediting_1391969 | chr8_141143490_+ | intronic |
| ADediting_1391970 | chr8_141143491_+ | intronic |
| ADediting_1391971 | chr8_141143492_+ | intronic |
| ADediting_1391972 | chr8_141143505_+ | intronic |
| ADediting_1391973 | chr8_141143534_+ | intronic |
| ADediting_1391974 | chr8_141143544_+ | intronic |
| ADediting_1391975 | chr8_141143562_+ | intronic |
| ADediting_1391976 | chr8_141143570_+ | intronic |
| ADediting_1391977 | chr8_141143571_+ | intronic |
| ADediting_1391978 | chr8_141143577_+ | intronic |
| ADediting_1391979 | chr8_141143606_+ | intronic |
| ADediting_1391980 | chr8_141143615_+ | intronic |
| ADediting_1391981 | chr8_141143640_+ | intronic |
| ADediting_1391982 | chr8_141143641_+ | intronic |
| ADediting_1391983 | chr8_141143680_+ | intronic |
| ADediting_1391984 | chr8_141161852_+ | intronic |
| ADediting_1391985 | chr8_141161895_+ | intronic |
| ADediting_1391986 | chr8_141161901_+ | intronic |
| ADediting_1391987 | chr8_141161904_+ | intronic |
| ADediting_1391988 | chr8_141161905_+ | intronic |
| ADediting_1391989 | chr8_141161965_+ | intronic |
| ADediting_1391990 | chr8_141162019_+ | intronic |
| ADediting_1391991 | chr8_141162039_+ | intronic |
| ADediting_1391992 | chr8_141162689_+ | intronic |
| ADediting_1391993 | chr8_141162738_+ | intronic |
| ADediting_1391994 | chr8_141162743_+ | intronic |
| ADediting_1391995 | chr8_141162749_+ | intronic |
| ADediting_1391996 | chr8_141162820_+ | intronic |
| ADediting_1391997 | chr8_141162822_+ | intronic |
| ADediting_1391998 | chr8_141162823_+ | intronic |
| ADediting_1391999 | chr8_141162829_+ | intronic |
| ADediting_1392000 | chr8_141162901_+ | intronic |
| ADediting_1392001 | chr8_141168567_+ | intronic |
| ADediting_1392002 | chr8_141168569_+ | intronic |
| ADediting_1392003 | chr8_141168626_+ | intronic |
| ADediting_1392004 | chr8_141172818_+ | intronic |
| ADediting_1392005 | chr8_141172831_+ | intronic |
| ADediting_1392006 | chr8_141172836_+ | intronic |
| ADediting_1392007 | chr8_141172860_+ | intronic |
| ADediting_1392008 | chr8_141181795_+ | intronic |
| ADediting_1392009 | chr8_141185570_+ | intronic |
| ADediting_1392010 | chr8_141185639_+ | intronic |
| ADediting_1392011 | chr8_141185640_+ | intronic |
| ADediting_1392012 | chr8_141185642_+ | intronic |
| ADediting_1392013 | chr8_141185644_+ | intronic |
| ADediting_1392014 | chr8_141185661_+ | intronic |
| ADediting_1392015 | chr8_141185666_+ | intronic |
| ADediting_1392016 | chr8_141185670_+ | intronic |
| ADediting_1392017 | chr8_141185705_+ | intronic |
| ADediting_1392018 | chr8_141185723_+ | intronic |
| ADediting_1392019 | chr8_141185745_+ | intronic |
| ADediting_1392020 | chr8_141185775_+ | intronic |
| ADediting_1392021 | chr8_141185807_+ | intronic |
| ADediting_1392022 | chr8_141185966_+ | intronic |
| ADediting_1392023 | chr8_141186006_+ | intronic |
| ADediting_1392024 | chr8_141186043_+ | intronic |
| ADediting_1392025 | chr8_141186051_+ | intronic |
| ADediting_1392026 | chr8_141186068_+ | intronic |
| ADediting_1392027 | chr8_141186069_+ | intronic |
| ADediting_1392028 | chr8_141186078_+ | intronic |
| ADediting_1392029 | chr8_141186080_+ | intronic |
| ADediting_1392030 | chr8_141186104_+ | intronic |
| ADediting_1392031 | chr8_141186121_+ | intronic |
| ADediting_1392032 | chr8_141186128_+ | intronic |
| ADediting_1392033 | chr8_141186187_+ | intronic |
| ADediting_1392034 | chr8_141187316_+ | intronic |
| ADediting_1392035 | chr8_141187318_+ | intronic |
| ADediting_1392036 | chr8_141187319_+ | intronic |
| ADediting_1392037 | chr8_141187352_+ | intronic |
| ADediting_1392038 | chr8_141187366_+ | intronic |
| ADediting_1392039 | chr8_141187382_+ | intronic |
| ADediting_1392040 | chr8_141187390_+ | intronic |
| ADediting_1392041 | chr8_141187408_+ | intronic |
| ADediting_1392042 | chr8_141187445_+ | intronic |
| ADediting_1392043 | chr8_141187446_+ | intronic |
| ADediting_1392044 | chr8_141187459_+ | intronic |
| ADediting_1392045 | chr8_141187460_+ | intronic |
| ADediting_1392046 | chr8_141187463_+ | intronic |
| ADediting_1392047 | chr8_141187488_+ | intronic |
| ADediting_1392048 | chr8_141187500_+ | intronic |
| ADediting_1392049 | chr8_141187931_+ | intronic |
| ADediting_1392050 | chr8_141187955_+ | intronic |
| ADediting_1392051 | chr8_141187958_+ | intronic |
| ADediting_1392052 | chr8_141187986_+ | intronic |
| ADediting_1392053 | chr8_141187991_+ | intronic |
| ADediting_1392054 | chr8_141188001_+ | intronic |
| ADediting_1392055 | chr8_141188022_+ | intronic |
| ADediting_1392056 | chr8_141188025_+ | intronic |
| ADediting_1392057 | chr8_141188026_+ | intronic |
| ADediting_1392058 | chr8_141188045_+ | intronic |
| ADediting_1392059 | chr8_141188064_+ | intronic |
| ADediting_1392060 | chr8_141188083_+ | intronic |
| ADediting_1392061 | chr8_141188129_+ | intronic |
| ADediting_1392062 | chr8_141188180_+ | intronic |
| ADediting_1589913 | chr8_141185586_+ | intronic |
| ADediting_1589914 | chr8_141185679_+ | intronic |
| ADediting_1589915 | chr8_141187334_+ | intronic |
| ADediting_1668746 | chr8_141161988_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1391933 | chr8_141138566_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1391934 | chr8_141138586_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1391935 | chr8_141138608_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1391936 | chr8_141141787_+ | SINE | Alu | Name=AluJo |
| ADediting_1391937 | chr8_141141788_+ | SINE | Alu | Name=AluJo |
| ADediting_1391938 | chr8_141141804_+ | SINE | Alu | Name=AluJo |
| ADediting_1391939 | chr8_141141809_+ | SINE | Alu | Name=AluJo |
| ADediting_1391940 | chr8_141141810_+ | SINE | Alu | Name=AluJo |
| ADediting_1391941 | chr8_141141812_+ | SINE | Alu | Name=AluJo |
| ADediting_1391942 | chr8_141141828_+ | SINE | Alu | Name=AluJo |
| ADediting_1391943 | chr8_141141833_+ | SINE | Alu | Name=AluJo |
| ADediting_1391944 | chr8_141141847_+ | SINE | Alu | Name=AluJo |
| ADediting_1391945 | chr8_141141852_+ | SINE | Alu | Name=AluJo |
| ADediting_1391946 | chr8_141141861_+ | SINE | Alu | Name=AluJo |
| ADediting_1391947 | chr8_141141864_+ | SINE | Alu | Name=AluJo |
| ADediting_1391948 | chr8_141141890_+ | SINE | Alu | Name=AluJo |
| ADediting_1391949 | chr8_141141891_+ | SINE | Alu | Name=AluJo |
| ADediting_1391950 | chr8_141141892_+ | SINE | Alu | Name=AluJo |
| ADediting_1391951 | chr8_141141893_+ | SINE | Alu | Name=AluJo |
| ADediting_1391952 | chr8_141141894_+ | SINE | Alu | Name=AluJo |
| ADediting_1391953 | chr8_141141897_+ | SINE | Alu | Name=AluJo |
| ADediting_1391954 | chr8_141141905_+ | SINE | Alu | Name=AluJo |
| ADediting_1391955 | chr8_141141923_+ | SINE | Alu | Name=AluJo |
| ADediting_1391956 | chr8_141141945_+ | SINE | Alu | Name=AluJo |
| ADediting_1391957 | chr8_141141963_+ | SINE | Alu | Name=AluJo |
| ADediting_1391958 | chr8_141141964_+ | SINE | Alu | Name=AluJo |
| ADediting_1391959 | chr8_141141977_+ | SINE | Alu | Name=AluJo |
| ADediting_1391960 | chr8_141141978_+ | SINE | Alu | Name=AluJo |
| ADediting_1391961 | chr8_141141985_+ | SINE | Alu | Name=AluJo |
| ADediting_1391962 | chr8_141142001_+ | SINE | Alu | Name=AluJo |
| ADediting_1391963 | chr8_141142007_+ | SINE | Alu | Name=AluJo |
| ADediting_1391964 | chr8_141142019_+ | SINE | Alu | Name=AluJo |
| ADediting_1391965 | chr8_141143431_+ | SINE | Alu | Name=AluJr |
| ADediting_1391966 | chr8_141143460_+ | SINE | Alu | Name=AluJr |
| ADediting_1391967 | chr8_141143479_+ | SINE | Alu | Name=AluJr |
| ADediting_1391968 | chr8_141143484_+ | SINE | Alu | Name=AluJr |
| ADediting_1391969 | chr8_141143490_+ | SINE | Alu | Name=AluJr |
| ADediting_1391970 | chr8_141143491_+ | SINE | Alu | Name=AluJr |
| ADediting_1391971 | chr8_141143492_+ | SINE | Alu | Name=AluJr |
| ADediting_1391972 | chr8_141143505_+ | SINE | Alu | Name=AluJr |
| ADediting_1391973 | chr8_141143534_+ | SINE | Alu | Name=AluJr |
| ADediting_1391974 | chr8_141143544_+ | SINE | Alu | Name=AluJr |
| ADediting_1391975 | chr8_141143562_+ | SINE | Alu | Name=AluJr |
| ADediting_1391976 | chr8_141143570_+ | SINE | Alu | Name=AluJr |
| ADediting_1391977 | chr8_141143571_+ | SINE | Alu | Name=AluJr |
| ADediting_1391978 | chr8_141143577_+ | SINE | Alu | Name=AluJr |
| ADediting_1391979 | chr8_141143606_+ | SINE | Alu | Name=AluJr |
| ADediting_1391980 | chr8_141143615_+ | SINE | Alu | Name=AluJr |
| ADediting_1391981 | chr8_141143640_+ | SINE | Alu | Name=AluJr |
| ADediting_1391982 | chr8_141143641_+ | SINE | Alu | Name=AluJr |
| ADediting_1391983 | chr8_141143680_+ | SINE | Alu | Name=AluJr |
| ADediting_1391984 | chr8_141161852_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1391985 | chr8_141161895_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1391986 | chr8_141161901_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1391987 | chr8_141161904_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1391988 | chr8_141161905_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1391989 | chr8_141161965_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1391990 | chr8_141162019_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1391991 | chr8_141162039_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1391992 | chr8_141162689_+ | SINE | Alu | Name=AluSx |
| ADediting_1391993 | chr8_141162738_+ | SINE | Alu | Name=AluSx |
| ADediting_1391994 | chr8_141162743_+ | SINE | Alu | Name=AluSx |
| ADediting_1391995 | chr8_141162749_+ | SINE | Alu | Name=AluSx |
| ADediting_1391996 | chr8_141162820_+ | SINE | Alu | Name=AluSx |
| ADediting_1391997 | chr8_141162822_+ | SINE | Alu | Name=AluSx |
| ADediting_1391998 | chr8_141162823_+ | SINE | Alu | Name=AluSx |
| ADediting_1391999 | chr8_141162829_+ | SINE | Alu | Name=AluSx |
| ADediting_1392000 | chr8_141162901_+ | SINE | Alu | Name=AluSx |
| ADediting_1392001 | chr8_141168567_+ | SINE | Alu | Name=AluJb |
| ADediting_1392002 | chr8_141168569_+ | SINE | Alu | Name=AluJb |
| ADediting_1392003 | chr8_141168626_+ | SINE | Alu | Name=AluJb |
| ADediting_1392004 | chr8_141172818_+ | SINE | Alu | Name=AluJr |
| ADediting_1392005 | chr8_141172831_+ | SINE | Alu | Name=AluJr |
| ADediting_1392006 | chr8_141172836_+ | SINE | Alu | Name=AluJr |
| ADediting_1392007 | chr8_141172860_+ | SINE | Alu | Name=AluJr |
| ADediting_1392008 | chr8_141181795_+ | SINE | Alu | Name=AluJb |
| ADediting_1392009 | chr8_141185570_+ | SINE | Alu | Name=AluJb |
| ADediting_1392010 | chr8_141185639_+ | SINE | Alu | Name=AluJb |
| ADediting_1392011 | chr8_141185640_+ | SINE | Alu | Name=AluJb |
| ADediting_1392012 | chr8_141185642_+ | SINE | Alu | Name=AluJb |
| ADediting_1392013 | chr8_141185644_+ | SINE | Alu | Name=AluJb |
| ADediting_1392014 | chr8_141185661_+ | SINE | Alu | Name=AluJb |
| ADediting_1392015 | chr8_141185666_+ | SINE | Alu | Name=AluJb |
| ADediting_1392016 | chr8_141185670_+ | SINE | Alu | Name=AluJb |
| ADediting_1392017 | chr8_141185705_+ | SINE | Alu | Name=AluJb |
| ADediting_1392018 | chr8_141185723_+ | SINE | Alu | Name=AluJb |
| ADediting_1392019 | chr8_141185745_+ | SINE | Alu | Name=AluJb |
| ADediting_1392020 | chr8_141185775_+ | SINE | Alu | Name=AluJb |
| ADediting_1392021 | chr8_141185807_+ | SINE | Alu | Name=AluJb |
| ADediting_1392022 | chr8_141185966_+ | SINE | Alu | Name=AluJb |
| ADediting_1392023 | chr8_141186006_+ | SINE | Alu | Name=AluJb |
| ADediting_1392024 | chr8_141186043_+ | SINE | Alu | Name=AluJb |
| ADediting_1392025 | chr8_141186051_+ | SINE | Alu | Name=AluJb |
| ADediting_1392026 | chr8_141186068_+ | SINE | Alu | Name=AluJb |
| ADediting_1392027 | chr8_141186069_+ | SINE | Alu | Name=AluJb |
| ADediting_1392028 | chr8_141186078_+ | SINE | Alu | Name=AluJb |
| ADediting_1392029 | chr8_141186080_+ | SINE | Alu | Name=AluJb |
| ADediting_1392030 | chr8_141186104_+ | SINE | Alu | Name=AluJb |
| ADediting_1392031 | chr8_141186121_+ | SINE | Alu | Name=AluJb |
| ADediting_1392032 | chr8_141186128_+ | SINE | Alu | Name=AluJb |
| ADediting_1392034 | chr8_141187316_+ | SINE | Alu | Name=AluJb |
| ADediting_1392035 | chr8_141187318_+ | SINE | Alu | Name=AluJb |
| ADediting_1392036 | chr8_141187319_+ | SINE | Alu | Name=AluJb |
| ADediting_1392037 | chr8_141187352_+ | SINE | Alu | Name=AluJb |
| ADediting_1392038 | chr8_141187366_+ | SINE | Alu | Name=AluJb |
| ADediting_1392039 | chr8_141187382_+ | SINE | Alu | Name=AluJb |
| ADediting_1392040 | chr8_141187390_+ | SINE | Alu | Name=AluJb |
| ADediting_1392041 | chr8_141187408_+ | SINE | Alu | Name=AluJb |
| ADediting_1392042 | chr8_141187445_+ | SINE | Alu | Name=AluJb |
| ADediting_1392043 | chr8_141187446_+ | SINE | Alu | Name=AluJb |
| ADediting_1392044 | chr8_141187459_+ | SINE | Alu | Name=AluJb |
| ADediting_1392045 | chr8_141187460_+ | SINE | Alu | Name=AluJb |
| ADediting_1392046 | chr8_141187463_+ | SINE | Alu | Name=AluJb |
| ADediting_1392047 | chr8_141187488_+ | SINE | Alu | Name=AluJb |
| ADediting_1392048 | chr8_141187500_+ | SINE | Alu | Name=AluJb |
| ADediting_1392049 | chr8_141187931_+ | SINE | Alu | Name=AluJb |
| ADediting_1392050 | chr8_141187955_+ | SINE | Alu | Name=AluJb |
| ADediting_1392051 | chr8_141187958_+ | SINE | Alu | Name=AluJb |
| ADediting_1392052 | chr8_141187986_+ | SINE | Alu | Name=AluJb |
| ADediting_1392053 | chr8_141187991_+ | SINE | Alu | Name=AluJb |
| ADediting_1392054 | chr8_141188001_+ | SINE | Alu | Name=AluJb |
| ADediting_1392055 | chr8_141188022_+ | SINE | Alu | Name=AluJb |
| ADediting_1392056 | chr8_141188025_+ | SINE | Alu | Name=AluJb |
| ADediting_1392057 | chr8_141188026_+ | SINE | Alu | Name=AluJb |
| ADediting_1392058 | chr8_141188045_+ | SINE | Alu | Name=AluJb |
| ADediting_1392059 | chr8_141188064_+ | SINE | Alu | Name=AluJb |
| ADediting_1392060 | chr8_141188083_+ | SINE | Alu | Name=AluJb |
| ADediting_1392061 | chr8_141188129_+ | SINE | Alu | Name=AluJb |
| ADediting_1392062 | chr8_141188180_+ | SINE | Alu | Name=AluJb |
| ADediting_1589913 | chr8_141185586_+ | SINE | Alu | Name=AluJb |
| ADediting_1589914 | chr8_141185679_+ | SINE | Alu | Name=AluJb |
| ADediting_1589915 | chr8_141187334_+ | SINE | Alu | Name=AluJb |
| ADediting_1668746 | chr8_141161988_+ | SINE | Alu | Name=AluSx1 |
Top |
RNA A-to-I editing events in the alternative splicing sites for DENND3 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| ES | ADediting_1392008 | chr8_141181795_+ | 141181777:141181799 | 3ss | 2i | TTTTTATTTTTTTGAGTCAGGGT | 3.29 | TTTTTATTTTTTTGAGTCGGGGT | -4.66 |
| ME1 | ADediting_1392008 | chr8_141181795_+ | 141181777:141181799 | 3ss | 2i | TTTTTATTTTTTTGAGTCAGGGT | 3.29 | TTTTTATTTTTTTGAGTCGGGGT | -4.66 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for DENND3 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for DENND3 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for DENND3 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1556067 | chr19_40282625_- | ENSG00000105339.10 | ENST00000262585.6 | DENND3-201 | hsa-miR-641 | chr8 | 141194460 | 141194466 | 7mer-1a | 141194439 | 141194466 | 140 | -20.55 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000105339.10 | ENST00000424248.2 | DENND3-202 | hsa-miR-641 | chr8 | 141194460 | 141194466 | 7mer-1a | 141194439 | 141194466 | 140 | -20.55 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000105339.10 | ENST00000518668.5 | DENND3-208 | hsa-miR-641 | chr8 | 141194460 | 141194466 | 7mer-1a | 141194439 | 141194466 | 140 | -20.55 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000105339.10 | ENST00000519811.5 | DENND3-211 | hsa-miR-641 | chr8 | 141194460 | 141194466 | 7mer-1a | 141194439 | 141194466 | 140 | -20.55 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000105339.10 | ENST00000523308.5 | DENND3-221 | hsa-miR-641 | chr8 | 141194460 | 141194466 | 7mer-1a | 141194439 | 141194466 | 140 | -20.55 |
| ADediting_291761 | chr11_93733708_- | ENSG00000105339.10 | ENST00000262585.6 | DENND3-201 | hsa-miR-1304-3p | chr8 | 141194716 | 141194722 | 7mer-m8 | 141194701 | 141194723 | 159 | -26.14 |
| ADediting_291761 | chr11_93733708_- | ENSG00000105339.10 | ENST00000424248.2 | DENND3-202 | hsa-miR-1304-3p | chr8 | 141194716 | 141194722 | 7mer-m8 | 141194701 | 141194723 | 159 | -26.14 |
| ADediting_291761 | chr11_93733708_- | ENSG00000105339.10 | ENST00000518668.5 | DENND3-208 | hsa-miR-1304-3p | chr8 | 141194716 | 141194722 | 7mer-m8 | 141194701 | 141194723 | 159 | -26.14 |
| ADediting_291761 | chr11_93733708_- | ENSG00000105339.10 | ENST00000519811.5 | DENND3-211 | hsa-miR-1304-3p | chr8 | 141194716 | 141194722 | 7mer-m8 | 141194701 | 141194723 | 159 | -26.14 |
| ADediting_291761 | chr11_93733708_- | ENSG00000105339.10 | ENST00000523308.5 | DENND3-221 | hsa-miR-1304-3p | chr8 | 141194716 | 141194722 | 7mer-m8 | 141194701 | 141194723 | 159 | -26.14 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_107020 | chr1_37500952_- | ENSG00000105339.10 | ENST00000262585.6 | DENND3-201 | hsa-miR-5581-3p | chr8 | 141194348 | 141194354 | 7mer-m8 | 141194334 | 141194355 | 140 | -15.09 |
| ADediting_107020 | chr1_37500952_- | ENSG00000105339.10 | ENST00000424248.2 | DENND3-202 | hsa-miR-5581-3p | chr8 | 141194348 | 141194354 | 7mer-m8 | 141194334 | 141194355 | 140 | -15.09 |
| ADediting_107020 | chr1_37500952_- | ENSG00000105339.10 | ENST00000518668.5 | DENND3-208 | hsa-miR-5581-3p | chr8 | 141194348 | 141194354 | 7mer-m8 | 141194334 | 141194355 | 140 | -15.09 |
| ADediting_107020 | chr1_37500952_- | ENSG00000105339.10 | ENST00000519811.5 | DENND3-211 | hsa-miR-5581-3p | chr8 | 141194348 | 141194354 | 7mer-m8 | 141194334 | 141194355 | 140 | -15.09 |
| ADediting_107020 | chr1_37500952_- | ENSG00000105339.10 | ENST00000523308.5 | DENND3-221 | hsa-miR-5581-3p | chr8 | 141194348 | 141194354 | 7mer-m8 | 141194334 | 141194355 | 140 | -15.09 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000105339.10 | ENST00000518249.5 | DENND3-206 | hsa-miR-5688 | chr8 | 141142655 | 141142661 | 7mer-m8 | 141142639 | 141142662 | 149 | -12.05 |
| ADediting_496066 | chr15_66496985_- | ENSG00000105339.10 | ENST00000520725.5 | DENND3-214 | hsa-miR-4512 | chr8 | 141193006 | 141193012 | 7mer-m8 | 141192992 | 141193013 | 152 | -22.67 |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for DENND3 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for DENND3 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| TCX | ADediting_1391937 | chr8_141141788_+ | 2.26243109130799e-05 | 0.338532901364927 | 0.000115418555945316 | 0.309631087282914 | 0.643270617692427 | -0.0381196099526978 |
| TCX | ADediting_1391945 | chr8_141141852_+ | 5.1318864896459e-06 | 0.362554519715872 | 6.60143194004141e-05 | 0.319873302708215 | 0.708773275651698 | 0.0307464802858621 |
| TCX | ADediting_1391951 | chr8_141141893_+ | 0.000786848575269395 | 0.271240412648741 | 4.76687237468901e-05 | 0.32567616285279 | 0.0709955666688003 | -0.147844500435508 |
| TCX | ADediting_1391953 | chr8_141141897_+ | 5.15789314693113e-06 | 0.362475900225701 | 8.61348035155245e-05 | 0.315042374886445 | 0.980160688448845 | 0.00204754559555669 |
| TCX | ADediting_1391957 | chr8_141141963_+ | 2.20911916840181e-05 | 0.338934999230623 | 9.25687209334242e-05 | 0.31371996657881 | 0.528195477326134 | 0.0519010345281868 |
| TCX | ADediting_1391959 | chr8_141141977_+ | 6.83691618303392e-05 | 0.319241527276004 | 0.0067306899121531 | 0.22037753879594 | 0.211946153924595 | 0.102506519989264 |
| TCX | ADediting_1391965 | chr8_141143431_+ | 0.000142583322158387 | 0.305657009621479 | 0.0123108573494484 | 0.203931265712947 | 0.388022678834445 | 0.0709855644249234 |
| TCX | ADediting_1391969 | chr8_141143490_+ | 0.000131010766764737 | 0.307255349711832 | 0.023428140696615 | 0.184996452982601 | 0.190016684644171 | 0.107593472062879 |
| STG | ADediting_1391969 | chr8_141143490_+ | 0.00290613008617407 | 0.321035957891047 | 0.258698912829864 | 0.124621648628269 | 0.0107508035323309 | 0.27698600133615 |
| DLPFC | ADediting_1392014 | chr8_141185661_+ | 0.00574062904809752 | 0.156548663549901 | 0.348285008631715 | 0.0534481647217645 | 2.13535290535989e-21 | 0.504238196875933 |
| DLPFC | ADediting_1392019 | chr8_141185745_+ | 3.12325201922902e-06 | 0.261256701021257 | 0.0235963422149113 | 0.128551477765823 | 3.41727026727572e-13 | 0.397728735276862 |
| DLPFC | ADediting_1392020 | chr8_141185775_+ | 2.9100576418315e-07 | 0.286351756871378 | 0.00770566955984722 | 0.151085484747472 | 3.4656534026961e-09 | 0.327565084421606 |
| DLPFC | ADediting_1392021 | chr8_141185807_+ | 3.5384854044916e-08 | 0.306746124584568 | 8.35834848282443e-05 | 0.221542083615417 | 3.27520594710705e-10 | 0.347209127802648 |
| DLPFC | ADediting_1392028 | chr8_141186078_+ | 4.2758743358282e-05 | 0.230213285768438 | 0.0201603196355302 | 0.131913202939568 | 2.51336872319884e-10 | 0.34933044638362 |
| DLPFC | ADediting_1392031 | chr8_141186121_+ | 2.8746775550333e-07 | 0.286474875048624 | 0.00149456646776119 | 0.179626096080261 | 5.91883193762804e-08 | 0.301910597648174 |
| DLPFC | ADediting_1392035 | chr8_141187318_+ | 1.12350127118435e-09 | 0.337117217253924 | 5.80704445518344e-07 | 0.27930019799273 | 9.01232261796699e-09 | 0.319193503616167 |
| DLPFC | ADediting_1392037 | chr8_141187352_+ | 2.16225208835483e-13 | 0.400806532540021 | 2.83987813017981e-08 | 0.308787001974299 | 5.26197093927368e-08 | 0.303024082490683 |
| DLPFC | ADediting_1392039 | chr8_141187382_+ | 4.38677892623158e-11 | 0.362935263642455 | 2.57833652716551e-07 | 0.287567323135865 | 1.12085533911664e-07 | 0.295783142155091 |
| DLPFC | ADediting_1392040 | chr8_141187390_+ | 9.50491645928058e-09 | 0.31871973025216 | 5.96919806388935e-07 | 0.279015029106095 | 6.31232344953254e-07 | 0.27843532291413 |
| DLPFC | ADediting_1392042 | chr8_141187445_+ | 1.37260812073122e-06 | 0.270237431092626 | 0.000460565248784675 | 0.197770527328001 | 1.43580163160058e-09 | 0.33506509325737 |
| DLPFC | ADediting_1392045 | chr8_141187460_+ | 4.34357281093919e-08 | 0.304829736695836 | 0.000442105614094226 | 0.198372707680787 | 7.52334228487776e-08 | 0.299625435456006 |
| DLPFC | ADediting_1392046 | chr8_141187463_+ | 2.89079662489865e-09 | 0.32912545626865 | 5.08853406373684e-05 | 0.227994243125271 | 9.65445395976457e-07 | 0.273984111009777 |
| DLPFC | ADediting_1392047 | chr8_141187488_+ | 4.73317234663665e-09 | 0.324862688653032 | 1.04208904860287e-08 | 0.317898696194739 | 0.00213348371363283 | 0.173793536136431 |
| DLPFC | ADediting_1392048 | chr8_141187500_+ | 2.07430762783561e-10 | 0.350858929642392 | 3.3889883413154e-06 | 0.26034658527045 | 0.000114199226042895 | 0.217386158596599 |
| DLPFC | ADediting_1392050 | chr8_141187955_+ | 8.10552645841213e-11 | 0.358223636525514 | 1.24880779609361e-07 | 0.294731556340897 | 4.6102424240555e-09 | 0.325091870160643 |
| DLPFC | ADediting_1392051 | chr8_141187958_+ | 1.4755424964523e-11 | 0.371112113800409 | 6.01535600887274e-09 | 0.322766094096418 | 8.36465386407058e-08 | 0.298609240090985 |
| DLPFC | ADediting_1392054 | chr8_141188001_+ | 1.07829705008465e-06 | 0.272813050371882 | 0.00054917734095529 | 0.195159803742526 | 1.44413005504862e-10 | 0.353719613211666 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.48717073595458e-26 | 0.556030016927713 | 1.05995083861194e-32 | 0.607844790294884 | 1.07631027487945e-09 | 0.337474697188973 |
| AC | 2.49578203469678e-10 | 0.386452074407106 | 5.5165389728788e-06 | 0.282919848474268 | 2.28273036825613e-10 | 0.387226107656916 |
| PCC | 4.19506259321951e-06 | 0.325952378767506 | 3.17644792003693e-05 | 0.296199500561108 | 5.34813733052385e-12 | 0.472188812701649 |
| CER | 4.15801804615081e-08 | 0.429465236581005 | 0.000466372698195545 | 0.282250884648457 | 9.54342010991458e-06 | 0.352746589724287 |
| TCX | 9.05594983681831e-08 | 0.4195934430997 | 0.0333249801083342 | 0.173890994240392 | 0.0134587925909864 | 0.201401020059562 |
| FP | 3.06432325324262e-23 | 0.655623125179917 | 4.93867679933329e-09 | 0.420850064109991 | 2.37153461073738e-07 | 0.375689465573152 |
| IFG | 0.0153317683633865 | 0.479331452296771 | 0.0463361956074289 | 0.402051074629907 | 0.00193477732865275 | 0.589349504222368 |
| PG | 8.15203534581951e-13 | 0.493605746648355 | 9.2698486273714e-13 | 0.492550873187985 | 0.0495279958225711 | 0.144227238028918 |
| STG | 1.30022850602409e-07 | 0.538091751021997 | 0.0147010278558247 | 0.26537386066379 | 0.00440093161563251 | 0.307762540531111 |
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Relation with AD stages for DENND3 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| TCX | ADediting_1391953 | chr8_141141897_+ | 0.000512660021254305 | 0.331754324297593 |
| TCX | ADediting_1391957 | chr8_141141963_+ | 3.30784959938248e-06 | 0.434246661899288 |
| TCX | ADediting_1391959 | chr8_141141977_+ | 0.000623196926674586 | 0.326999708651409 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 3.45174653234265e-05 | 0.38734254842573 |
| TCX | 2.29835143456506e-05 | 0.398754909759143 |
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RelatedDrugs for DENND3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DENND3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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