|
||||||
|
 | |
| |
| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
| |
| |
| The effects of the RNA editing to the stability of the RNA structures |
| |
| |
| |
|
Gene summary for VASH1 |
 Gene summary |
| Gene information | Gene symbol | VASH1 | Gene ID | 22846 |
| Gene name | vasohibin 1 | |
| Synonyms | KIAA1036|TTCP 1 | |
| Cytomap | 14q24.3 | |
| Type of gene | protein-coding | |
| Description | tubulinyl-Tyr carboxypeptidase 1tubulin carboxypeptidase 1tyrosine carboxypeptidase 1 | |
| Modification date | 20200313 | |
| UniProtAcc | Q7L8A9, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| VASH1 | GO:0001525 | angiogenesis | 15467828 |
| VASH1 | GO:0001937 | negative regulation of endothelial cell proliferation | 15467828|19204325 |
| VASH1 | GO:0006508 | proteolysis | 29146869 |
| VASH1 | GO:0009611 | response to wounding | 23056314 |
| VASH1 | GO:0016525 | negative regulation of angiogenesis | 15467828 |
| VASH1 | GO:0043537 | negative regulation of blood vessel endothelial cell migration | 15467828 |
Top |
RNA A-to-I events for VASH1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_452695(76764786, +), ADediting_452696(76764803, +), ADediting_452697(76764851, +), ADediting_452698(76764852, +), ADediting_452699(76764860, +), ADediting_452700(76764912, +), ADediting_452701(76764913, +), ADediting_452702(76764926, +), ADediting_452703(76764930, +), ADediting_452704(76764939, +), ADediting_452705(76764944, +), ADediting_452706(76766457, +), ADediting_452707(76766480, +), ADediting_452708(76766485, +), ADediting_452709(76766492, +), ADediting_452710(76766540, +), ADediting_452711(76766541, +), ADediting_452712(76766545, +), ADediting_452713(76766553, +), ADediting_452714(76766558, +), ADediting_452715(76766570, +), ADediting_452716(76766651, +), ADediting_452717(76766662, +), ADediting_452718(76766663, +), ADediting_452719(76766664, +), ADediting_452720(76766677, +), ADediting_452721(76766694, +), ADediting_452722(76766738, +), ADediting_452723(76767013, +), ADediting_452724(76767016, +), ADediting_452725(76767030, +), ADediting_452726(76767035, +), ADediting_452727(76767046, +), ADediting_452728(76767059, +), ADediting_452729(76767068, +), ADediting_452730(76767087, +), ADediting_452731(76767089, +), ADediting_452732(76767092, +), ADediting_452733(76767093, +), ADediting_452734(76767094, +), ADediting_452735(76767095, +), ADediting_452736(76767098, +), ADediting_452737(76767134, +), ADediting_452738(76767147, +), ADediting_452739(76767151, +), ADediting_452740(76767156, +), ADediting_452741(76767157, +), ADediting_452742(76767166, +), ADediting_452743(76767170, +), ADediting_452744(76768413, +), ADediting_452745(76768742, +), ADediting_1537925(76764815, +), ADediting_1537926(76766453, +), ADediting_1537927(76766606, +), ADediting_1537928(76766676, +), ADediting_1537929(76766703, +), ADediting_1537930(76766995, +), ADediting_1537931(76767069, +), ADediting_1537932(76767080, +), ADediting_1537933(76767084, +), ADediting_1537934(76767091, +), ADediting_1537935(76767141, +), ADediting_1537936(76767154, +), ADediting_1537937(76767160, +), ADediting_1537938(76767165, +), ADediting_1537939(76767235, +), |
Top |
RNA editing positional annotations for VASH1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_452695 | chr14_76764786_+ | intronic |
| ADediting_452696 | chr14_76764803_+ | intronic |
| ADediting_452697 | chr14_76764851_+ | intronic |
| ADediting_452698 | chr14_76764852_+ | intronic |
| ADediting_452699 | chr14_76764860_+ | intronic |
| ADediting_452700 | chr14_76764912_+ | intronic |
| ADediting_452701 | chr14_76764913_+ | intronic |
| ADediting_452702 | chr14_76764926_+ | intronic |
| ADediting_452703 | chr14_76764930_+ | intronic |
| ADediting_452704 | chr14_76764939_+ | intronic |
| ADediting_452705 | chr14_76764944_+ | intronic |
| ADediting_452706 | chr14_76766457_+ | intronic |
| ADediting_452707 | chr14_76766480_+ | intronic |
| ADediting_452708 | chr14_76766485_+ | intronic |
| ADediting_452709 | chr14_76766492_+ | intronic |
| ADediting_452710 | chr14_76766540_+ | intronic |
| ADediting_452711 | chr14_76766541_+ | intronic |
| ADediting_452712 | chr14_76766545_+ | intronic |
| ADediting_452713 | chr14_76766553_+ | intronic |
| ADediting_452714 | chr14_76766558_+ | intronic |
| ADediting_452715 | chr14_76766570_+ | intronic |
| ADediting_452716 | chr14_76766651_+ | intronic |
| ADediting_452717 | chr14_76766662_+ | intronic |
| ADediting_452718 | chr14_76766663_+ | intronic |
| ADediting_452719 | chr14_76766664_+ | intronic |
| ADediting_452720 | chr14_76766677_+ | intronic |
| ADediting_452721 | chr14_76766694_+ | intronic |
| ADediting_452722 | chr14_76766738_+ | intronic |
| ADediting_452723 | chr14_76767013_+ | intronic |
| ADediting_452724 | chr14_76767016_+ | intronic |
| ADediting_452725 | chr14_76767030_+ | intronic |
| ADediting_452726 | chr14_76767035_+ | intronic |
| ADediting_452727 | chr14_76767046_+ | intronic |
| ADediting_452728 | chr14_76767059_+ | intronic |
| ADediting_452729 | chr14_76767068_+ | intronic |
| ADediting_452730 | chr14_76767087_+ | intronic |
| ADediting_452731 | chr14_76767089_+ | intronic |
| ADediting_452732 | chr14_76767092_+ | intronic |
| ADediting_452733 | chr14_76767093_+ | intronic |
| ADediting_452734 | chr14_76767094_+ | intronic |
| ADediting_452735 | chr14_76767095_+ | intronic |
| ADediting_452736 | chr14_76767098_+ | intronic |
| ADediting_452737 | chr14_76767134_+ | intronic |
| ADediting_452738 | chr14_76767147_+ | intronic |
| ADediting_452739 | chr14_76767151_+ | intronic |
| ADediting_452740 | chr14_76767156_+ | intronic |
| ADediting_452741 | chr14_76767157_+ | intronic |
| ADediting_452742 | chr14_76767166_+ | intronic |
| ADediting_452743 | chr14_76767170_+ | intronic |
| ADediting_452744 | chr14_76768413_+ | intronic |
| ADediting_452745 | chr14_76768742_+ | intronic |
| ADediting_1537925 | chr14_76764815_+ | intronic |
| ADediting_1537926 | chr14_76766453_+ | intronic |
| ADediting_1537927 | chr14_76766606_+ | intronic |
| ADediting_1537928 | chr14_76766676_+ | intronic |
| ADediting_1537929 | chr14_76766703_+ | intronic |
| ADediting_1537930 | chr14_76766995_+ | intronic |
| ADediting_1537931 | chr14_76767069_+ | intronic |
| ADediting_1537932 | chr14_76767080_+ | intronic |
| ADediting_1537933 | chr14_76767084_+ | intronic |
| ADediting_1537934 | chr14_76767091_+ | intronic |
| ADediting_1537935 | chr14_76767141_+ | intronic |
| ADediting_1537936 | chr14_76767154_+ | intronic |
| ADediting_1537937 | chr14_76767160_+ | intronic |
| ADediting_1537938 | chr14_76767165_+ | intronic |
| ADediting_1537939 | chr14_76767235_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_452695 | chr14_76764786_+ | SINE | Alu | Name=AluSx1 |
| ADediting_452696 | chr14_76764803_+ | SINE | Alu | Name=AluSx1 |
| ADediting_452697 | chr14_76764851_+ | SINE | Alu | Name=AluSx1 |
| ADediting_452698 | chr14_76764852_+ | SINE | Alu | Name=AluSx1 |
| ADediting_452699 | chr14_76764860_+ | SINE | Alu | Name=AluSx1 |
| ADediting_452700 | chr14_76764912_+ | SINE | Alu | Name=AluSx1 |
| ADediting_452701 | chr14_76764913_+ | SINE | Alu | Name=AluSx1 |
| ADediting_452702 | chr14_76764926_+ | SINE | Alu | Name=AluSx1 |
| ADediting_452703 | chr14_76764930_+ | SINE | Alu | Name=AluSx1 |
| ADediting_452704 | chr14_76764939_+ | SINE | Alu | Name=AluSx1 |
| ADediting_452705 | chr14_76764944_+ | SINE | Alu | Name=AluSx1 |
| ADediting_452706 | chr14_76766457_+ | SINE | Alu | Name=AluJo |
| ADediting_452707 | chr14_76766480_+ | SINE | Alu | Name=AluJo |
| ADediting_452708 | chr14_76766485_+ | SINE | Alu | Name=AluJo |
| ADediting_452709 | chr14_76766492_+ | SINE | Alu | Name=AluJo |
| ADediting_452710 | chr14_76766540_+ | SINE | Alu | Name=AluJo |
| ADediting_452711 | chr14_76766541_+ | SINE | Alu | Name=AluJo |
| ADediting_452712 | chr14_76766545_+ | SINE | Alu | Name=AluJo |
| ADediting_452713 | chr14_76766553_+ | SINE | Alu | Name=AluJo |
| ADediting_452714 | chr14_76766558_+ | SINE | Alu | Name=AluJo |
| ADediting_452715 | chr14_76766570_+ | SINE | Alu | Name=AluJo |
| ADediting_452716 | chr14_76766651_+ | SINE | Alu | Name=AluJo |
| ADediting_452717 | chr14_76766662_+ | SINE | Alu | Name=AluJo |
| ADediting_452718 | chr14_76766663_+ | SINE | Alu | Name=AluJo |
| ADediting_452719 | chr14_76766664_+ | SINE | Alu | Name=AluJo |
| ADediting_452720 | chr14_76766677_+ | SINE | Alu | Name=AluJo |
| ADediting_452721 | chr14_76766694_+ | SINE | Alu | Name=AluJo |
| ADediting_452722 | chr14_76766738_+ | SINE | Alu | Name=AluJo |
| ADediting_452723 | chr14_76767013_+ | SINE | Alu | Name=AluSz |
| ADediting_452724 | chr14_76767016_+ | SINE | Alu | Name=AluSz |
| ADediting_452725 | chr14_76767030_+ | SINE | Alu | Name=AluSz |
| ADediting_452726 | chr14_76767035_+ | SINE | Alu | Name=AluSz |
| ADediting_452727 | chr14_76767046_+ | SINE | Alu | Name=AluSz |
| ADediting_452728 | chr14_76767059_+ | SINE | Alu | Name=AluSz |
| ADediting_452729 | chr14_76767068_+ | SINE | Alu | Name=AluSz |
| ADediting_452730 | chr14_76767087_+ | SINE | Alu | Name=AluSz |
| ADediting_452731 | chr14_76767089_+ | SINE | Alu | Name=AluSz |
| ADediting_452732 | chr14_76767092_+ | SINE | Alu | Name=AluSz |
| ADediting_452733 | chr14_76767093_+ | SINE | Alu | Name=AluSz |
| ADediting_452734 | chr14_76767094_+ | SINE | Alu | Name=AluSz |
| ADediting_452735 | chr14_76767095_+ | SINE | Alu | Name=AluSz |
| ADediting_452736 | chr14_76767098_+ | SINE | Alu | Name=AluSz |
| ADediting_452737 | chr14_76767134_+ | SINE | Alu | Name=AluSz |
| ADediting_452738 | chr14_76767147_+ | SINE | Alu | Name=AluSz |
| ADediting_452739 | chr14_76767151_+ | SINE | Alu | Name=AluSz |
| ADediting_452740 | chr14_76767156_+ | SINE | Alu | Name=AluSz |
| ADediting_452741 | chr14_76767157_+ | SINE | Alu | Name=AluSz |
| ADediting_452742 | chr14_76767166_+ | SINE | Alu | Name=AluSz |
| ADediting_452743 | chr14_76767170_+ | SINE | Alu | Name=AluSz |
| ADediting_1537925 | chr14_76764815_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1537926 | chr14_76766453_+ | SINE | Alu | Name=AluJo |
| ADediting_1537927 | chr14_76766606_+ | SINE | Alu | Name=AluJo |
| ADediting_1537928 | chr14_76766676_+ | SINE | Alu | Name=AluJo |
| ADediting_1537929 | chr14_76766703_+ | SINE | Alu | Name=AluJo |
| ADediting_1537930 | chr14_76766995_+ | SINE | Alu | Name=AluSz |
| ADediting_1537931 | chr14_76767069_+ | SINE | Alu | Name=AluSz |
| ADediting_1537932 | chr14_76767080_+ | SINE | Alu | Name=AluSz |
| ADediting_1537933 | chr14_76767084_+ | SINE | Alu | Name=AluSz |
| ADediting_1537934 | chr14_76767091_+ | SINE | Alu | Name=AluSz |
| ADediting_1537935 | chr14_76767141_+ | SINE | Alu | Name=AluSz |
| ADediting_1537936 | chr14_76767154_+ | SINE | Alu | Name=AluSz |
| ADediting_1537937 | chr14_76767160_+ | SINE | Alu | Name=AluSz |
| ADediting_1537938 | chr14_76767165_+ | SINE | Alu | Name=AluSz |
| ADediting_1537939 | chr14_76767235_+ | SINE | Alu | Name=AluSz |
Top |
RNA A-to-I editing events in the alternative splicing sites for VASH1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for VASH1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
 | |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
 |
 |
 |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for VASH1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for VASH1 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000071246.11 | ENST00000167106.9 | VASH1-201 | hsa-miR-5688 | chr14 | 76780360 | 76780367 | 8mer-1a | 76780346 | 76780367 | 154 | -15 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000071246.11 | ENST00000167106.9 | VASH1-201 | hsa-miR-589-3p | chr14 | 76781816 | 76781822 | 7mer-m8 | 76781801 | 76781823 | 155 | -18.69 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000071246.11 | ENST00000167106.9 | VASH1-201 | hsa-miR-151a-3p | chr14 | 76779873 | 76779879 | 7mer-m8 | 76779862 | 76779880 | 147 | -23.76 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000071246.11 | ENST00000554743.1 | VASH1-204 | hsa-miR-151a-3p | chr14 | 76779873 | 76779879 | 7mer-m8 | 76779862 | 76779880 | 147 | -23.76 |
| ADediting_496066 | chr15_66496985_- | ENSG00000071246.11 | ENST00000167106.9 | VASH1-201 | hsa-miR-4512 | chr14 | 76779036 | 76779043 | 8mer-1a | 76779018 | 76779043 | 141 | -24.01 |
| ADediting_496066 | chr15_66496985_- | ENSG00000071246.11 | ENST00000167106.9 | VASH1-201 | hsa-miR-4512 | chr14 | 76779642 | 76779648 | 7mer-m8 | 76779628 | 76779649 | 150 | -21.77 |
| ADediting_496066 | chr15_66496985_- | ENSG00000071246.11 | ENST00000554743.1 | VASH1-204 | hsa-miR-4512 | chr14 | 76779642 | 76779648 | 7mer-m8 | 76779628 | 76779649 | 150 | -21.77 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_107020 | chr1_37500952_- | ENSG00000071246.11 | ENST00000167106.9 | VASH1-201 | hsa-miR-5581-3p | chr14 | 76781001 | 76781007 | 7mer-m8 | 76780987 | 76781008 | 143 | -17.94 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000071246.11 | ENST00000167106.9 | VASH1-201 | hsa-miR-5682 | chr14 | 76782694 | 76782700 | 7mer-m8 | 76782679 | 76782701 | 153 | -17.55 |
| ADediting_496066 | chr15_66496985_- | ENSG00000071246.11 | ENST00000167106.9 | VASH1-201 | hsa-miR-4512 | chr14 | 76779633 | 76779639 | 7mer-m8 | 76779620 | 76779640 | 150 | -17.64 |
| ADediting_496066 | chr15_66496985_- | ENSG00000071246.11 | ENST00000167106.9 | VASH1-201 | hsa-miR-4512 | chr14 | 76779727 | 76779734 | 8mer-1a | 76779711 | 76779734 | 145 | -22.11 |
| ADediting_496066 | chr15_66496985_- | ENSG00000071246.11 | ENST00000167106.9 | VASH1-201 | hsa-miR-4512 | chr14 | 76780963 | 76780969 | 7mer-m8 | 76780946 | 76780970 | 150 | -23.65 |
| ADediting_496066 | chr15_66496985_- | ENSG00000071246.11 | ENST00000554743.1 | VASH1-204 | hsa-miR-4512 | chr14 | 76779633 | 76779639 | 7mer-m8 | 76779620 | 76779640 | 150 | -17.64 |
| ADediting_496066 | chr15_66496985_- | ENSG00000071246.11 | ENST00000554743.1 | VASH1-204 | hsa-miR-4512 | chr14 | 76779727 | 76779734 | 8mer-1a | 76779711 | 76779734 | 145 | -22.11 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000071246.11 | ENST00000167106.9 | VASH1-201 | hsa-miR-1273h-3p | chr14 | 76781636 | 76781643 | 8mer-1a | 76781621 | 76781643 | 141 | -16.95 |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for VASH1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for VASH1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_452699 | chr14_76764860_+ | 9.60583066246792e-05 | 0.31303826057915 | 6.34926563065754e-06 | 0.359225638219698 | 0.33082289634815 | 0.0799424298449513 |
| CER | ADediting_452700 | chr14_76764912_+ | 5.70569467238821e-05 | 0.322486774745865 | 0.000168541529330251 | 0.302471629452025 | 0.131963284615803 | 0.123559252253494 |
| CER | ADediting_452703 | chr14_76764930_+ | 3.99646233315593e-07 | 0.399839814703033 | 1.05119905782717e-08 | 0.446170467756801 | 0.165711531974641 | 0.113759782705024 |
| DLPFC | ADediting_452704 | chr14_76764939_+ | 0.0048105645187082 | 0.159749849328258 | 0.198641556965594 | 0.0732053403880159 | 5.05590936225833e-13 | 0.395069053589904 |
| CER | ADediting_452704 | chr14_76764939_+ | 7.92840034874811e-06 | 0.355711879612738 | 1.36670464298212e-07 | 0.414243215272559 | 0.000978097124700154 | 0.266522330068879 |
| CER | ADediting_452705 | chr14_76764944_+ | 5.73290369709124e-06 | 0.360827239112786 | 2.16369492276989e-07 | 0.408158929340871 | 0.0215196528118983 | 0.187591254339537 |
| CER | ADediting_452706 | chr14_76766457_+ | 2.70966948244071e-05 | 0.335473010596633 | 0.000502770115284073 | 0.280696593780903 | 0.33980283646228 | 0.0784752871403217 |
| DLPFC | ADediting_452707 | chr14_76766480_+ | 0.00102318863436334 | 0.185648672094189 | 0.696868061399303 | 0.0222120520431224 | 4.23004783505887e-16 | 0.439873410248401 |
| CER | ADediting_452707 | chr14_76766480_+ | 2.16004681230224e-11 | 0.511877504991035 | 2.69718102454914e-09 | 0.461855760919549 | 0.0219232138479575 | 0.187026506729005 |
| DLPFC | ADediting_452708 | chr14_76766485_+ | 0.000379465640591803 | 0.200606511479139 | 0.68810329845439 | 0.0228891918817647 | 3.91398935166726e-22 | 0.512204881361824 |
| CER | ADediting_452708 | chr14_76766485_+ | 1.62062786090814e-12 | 0.535706606917139 | 2.91356760483083e-12 | 0.530470153741255 | 0.00616767007124527 | 0.222664730908291 |
| CER | ADediting_452711 | chr14_76766541_+ | 3.21397589120913e-05 | 0.332547680313972 | 2.18093644987664e-05 | 0.339151272129839 | 0.000210526296524637 | 0.298178071193446 |
| CER | ADediting_452713 | chr14_76766553_+ | 3.61056901191144e-06 | 0.36797289317156 | 3.87851178292522e-05 | 0.329291859854954 | 0.0210236539607004 | 0.188297999844412 |
| DLPFC | ADediting_452715 | chr14_76766570_+ | 0.0547664360527589 | 0.10920451909065 | 0.432966737567844 | 0.044693602724548 | 4.51731280816152e-08 | 0.304461520543934 |
| CER | ADediting_452715 | chr14_76766570_+ | 2.43444744846374e-05 | 0.337293746365884 | 2.42153024226443e-05 | 0.337383887531443 | 0.0897919474948962 | 0.139007860995692 |
| DLPFC | ADediting_452717 | chr14_76766662_+ | 0.005245619619418 | 0.158188967737271 | 0.111656040106727 | 0.0905311063523114 | 1.11641156408212e-10 | 0.355735626993765 |
| DLPFC | ADediting_452721 | chr14_76766694_+ | 0.0241046515845731 | 0.128090684858021 | 0.149622047014509 | 0.0820291953361658 | 1.89552064851471e-10 | 0.351573660705375 |
| CER | ADediting_452721 | chr14_76766694_+ | 2.00341018743982e-10 | 0.489795539547232 | 5.4132655427957e-09 | 0.45392194348763 | 0.355580572546845 | 0.0759558735610065 |
| CER | ADediting_452723 | chr14_76767013_+ | 1.23797505473e-10 | 0.494703404251515 | 2.05612909513929e-07 | 0.408840225698322 | 0.0674705374344099 | 0.149708415035606 |
| DLPFC | ADediting_452724 | chr14_76767016_+ | 0.751973171947511 | 0.0180211323440916 | 0.110616216384207 | -0.0907938469221344 | 1.43469293679391e-16 | 0.446161310128591 |
| CER | ADediting_452724 | chr14_76767016_+ | 1.87901788817898e-10 | 0.490453595509001 | 4.75532077838861e-09 | 0.455413193979538 | 0.00841045841007486 | 0.214442569161553 |
| CER | ADediting_452726 | chr14_76767035_+ | 7.83646736129438e-10 | 0.475452086609661 | 4.17808351801362e-11 | 0.505499867411128 | 0.00479444161962237 | 0.229139874639125 |
| CER | ADediting_452728 | chr14_76767059_+ | 3.63768112008782e-06 | 0.367858626363889 | 3.67838262023527e-07 | 0.400977577310001 | 0.000581218226824673 | 0.277672012133512 |
| DLPFC | ADediting_452729 | chr14_76767068_+ | 0.00101817450692451 | 0.18572555624367 | 0.122169756640359 | 0.0879766714124479 | 4.01579375363106e-10 | 0.345564885785504 |
| CER | ADediting_452729 | chr14_76767068_+ | 5.88594162307972e-06 | 0.36041487730759 | 2.67847617454463e-07 | 0.40529078787724 | 0.00755686913387753 | 0.217311945630616 |
| CER | ADediting_452730 | chr14_76767087_+ | 0.000286123693054624 | 0.292143765355349 | 7.11557238953956e-05 | 0.31851973644437 | 0.100910316561564 | 0.134458555175501 |
| DLPFC | ADediting_452732 | chr14_76767092_+ | 0.00248423831139959 | 0.171243762319872 | 0.118771138926739 | 0.0887829579118765 | 7.17698591850481e-11 | 0.359163495966199 |
| CER | ADediting_452732 | chr14_76767092_+ | 0.000184594774015207 | 0.300723452347834 | 8.80613549119185e-05 | 0.314636968544472 | 0.00167998993474212 | 0.254408641881508 |
| DLPFC | ADediting_452734 | chr14_76767094_+ | 0.00359153448318441 | 0.164921241593256 | 0.516439049251466 | 0.0369886895423283 | 1.7098401535227e-14 | 0.417316727234697 |
| DLPFC | ADediting_452735 | chr14_76767095_+ | 0.00435549958043651 | 0.161524934493657 | 0.267156649193317 | 0.063215314102445 | 3.36812215898492e-11 | 0.364939625228315 |
| CER | ADediting_452735 | chr14_76767095_+ | 0.000136130463864132 | 0.306532639971993 | 0.00123812764320756 | 0.26131241971706 | 0.0182609750571313 | 0.192520437494072 |
| DLPFC | ADediting_452736 | chr14_76767098_+ | 0.015099081175093 | 0.137911403115204 | 0.986966636261964 | 0.00093156428110819 | 1.72171577357226e-13 | 0.402326814085276 |
| CER | ADediting_452736 | chr14_76767098_+ | 1.13188938338091e-05 | 0.349991086179741 | 5.02180798974347e-06 | 0.362891529891079 | 0.233937431592804 | 0.0977705978104013 |
| DLPFC | ADediting_452737 | chr14_76767134_+ | 0.0448636136840642 | 0.11401804125291 | 0.773313632570973 | 0.0164250065846782 | 9.56135750226559e-10 | 0.338458641325649 |
| CER | ADediting_452737 | chr14_76767134_+ | 0.00036846438363557 | 0.287067409551195 | 4.00479555852673e-06 | 0.366386170784521 | 0.000710185412594283 | 0.273434449601835 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 8.22607566150286e-18 | 0.462186462732143 | 1.1410438316849e-13 | 0.405052422932072 | 5.73858834162247e-29 | 0.577489671850396 |
| AC | 5.36216788000772e-32 | 0.654814211090729 | 2.11323803309861e-24 | 0.585522637483377 | 1.06881771226852e-20 | 0.544471543709793 |
| PCC | 8.88897763310147e-06 | 0.315285910779912 | 3.55507343301697e-06 | 0.328250253163122 | 0.00303637092524407 | 0.213394660608842 |
| CER | 5.72433884681099e-30 | 0.764080976222962 | 1.58533198922613e-27 | 0.742380591984326 | 0.00315490829107203 | 0.239532854474899 |
| TCX | 0.00846577735839906 | 0.214265653518248 | 0.254954712416176 | -0.0935282365140401 | 2.55341292086054e-09 | 0.462471080056204 |
| FP | 3.3145623296585e-08 | 0.399482938626003 | 0.00066849363304029 | 0.252635139399421 | 3.06671220064225e-17 | 0.577793311736408 |
| IFG | 0.000445507430924076 | 0.649247561059445 | 0.000240195032120572 | 0.671142758676707 | 0.00163990739539382 | 0.596720649501985 |
| PG | 0.801350084917033 | 0.0185718305900339 | 0.224040343031574 | 0.089575303025339 | 4.39224881060591e-07 | 0.360281042623212 |
| STG | 0.000345055646436504 | 0.381337806864425 | 0.250939858006548 | 0.12665723676375 | 2.66141472332724e-08 | 0.561988350217956 |
Top |
Relation with AD stages for VASH1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_452699 | chr14_76764860_+ | 0.000987557221891636 | 0.312623628242992 |
| CER | ADediting_452703 | chr14_76764930_+ | 9.65318018469438e-05 | 0.366329002220728 |
| CER | ADediting_452704 | chr14_76764939_+ | 3.2658634871273e-05 | 0.388433976407419 |
| CER | ADediting_452705 | chr14_76764944_+ | 0.00080356150808947 | 0.317799183919315 |
| CER | ADediting_452707 | chr14_76766480_+ | 0.000217317558530266 | 0.348662100441234 |
| CER | ADediting_452708 | chr14_76766485_+ | 0.000108895805034337 | 0.363769325536455 |
| CER | ADediting_452723 | chr14_76767013_+ | 0.00127615176247208 | 0.306056553267053 |
| CER | ADediting_452724 | chr14_76767016_+ | 0.00139503815642866 | 0.303739412240359 |
| CER | ADediting_452728 | chr14_76767059_+ | 0.000148032857564122 | 0.357149066561233 |
| CER | ADediting_452729 | chr14_76767068_+ | 0.000209367054145469 | 0.349496545097603 |
| CER | ADediting_452735 | chr14_76767095_+ | 0.000314300870661239 | 0.340273210579346 |
| CER | ADediting_452737 | chr14_76767134_+ | 0.00105277513817124 | 0.310999412689946 |
| TCX | ADediting_452723 | chr14_76767013_+ | 0.00164912264583702 | 0.302078547780112 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 5.56571477047288e-08 | 0.493931739719772 |
| TCX | 1.1492051098179e-06 | 0.452036580251659 |
Top |
RelatedDrugs for VASH1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for VASH1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|