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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for HEPACAM |
 Gene summary |
| Gene information | Gene symbol | HEPACAM | Gene ID | 220296 |
| Gene name | hepatic and glial cell adhesion molecule | |
| Synonyms | GlialCAM|HEPN1|MLC2A|MLC2B | |
| Cytomap | 11q24.2 | |
| Type of gene | protein-coding | |
| Description | hepatocyte cell adhesion moleculePutative cancer susceptibility gene HEPN1 proteinprotein hepaCAM | |
| Modification date | 20200322 | |
| UniProtAcc | Q14CZ8, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for HEPACAM |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_241257(124925944, -), ADediting_241258(124925956, -), ADediting_241259(124925957, -), ADediting_241260(124926009, -), ADediting_241261(124926018, -), ADediting_241262(124926074, -), ADediting_241263(124926078, -), ADediting_241264(124926080, -), ADediting_241265(124926090, -), ADediting_241266(124926119, -), ADediting_241267(124926155, -), ADediting_241268(124926161, -), ADediting_241269(124926168, -), ADediting_241270(124926169, -), ADediting_241271(124926901, -), ADediting_241272(124926907, -), ADediting_241273(124926926, -), ADediting_241274(124926993, -), ADediting_241275(124927006, -), ADediting_241276(124927054, -), ADediting_241277(124927075, -), ADediting_241278(124927104, -), ADediting_241279(124927410, -), ADediting_241280(124927411, -), ADediting_241281(124927428, -), ADediting_241282(124927475, -), ADediting_241283(124927489, -), ADediting_241284(124927665, -), ADediting_241285(124927711, -), ADediting_241286(124927769, -), ADediting_241287(124927775, -), ADediting_241288(124927815, -), ADediting_241289(124927822, -), ADediting_241290(124927839, -), ADediting_241297(124933348, -), ADediting_241298(124934474, -), |
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RNA editing positional annotations for HEPACAM using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_241257 | chr11_124925944_- | intronic |
| ADediting_241258 | chr11_124925956_- | intronic |
| ADediting_241259 | chr11_124925957_- | intronic |
| ADediting_241260 | chr11_124926009_- | intronic |
| ADediting_241261 | chr11_124926018_- | intronic |
| ADediting_241262 | chr11_124926074_- | intronic |
| ADediting_241263 | chr11_124926078_- | intronic |
| ADediting_241264 | chr11_124926080_- | intronic |
| ADediting_241265 | chr11_124926090_- | intronic |
| ADediting_241266 | chr11_124926119_- | intronic |
| ADediting_241267 | chr11_124926155_- | intronic |
| ADediting_241268 | chr11_124926161_- | intronic |
| ADediting_241269 | chr11_124926168_- | intronic |
| ADediting_241270 | chr11_124926169_- | intronic |
| ADediting_241271 | chr11_124926901_- | intronic |
| ADediting_241272 | chr11_124926907_- | intronic |
| ADediting_241273 | chr11_124926926_- | intronic |
| ADediting_241274 | chr11_124926993_- | intronic |
| ADediting_241275 | chr11_124927006_- | intronic |
| ADediting_241276 | chr11_124927054_- | intronic |
| ADediting_241277 | chr11_124927075_- | intronic |
| ADediting_241278 | chr11_124927104_- | intronic |
| ADediting_241279 | chr11_124927410_- | intronic |
| ADediting_241280 | chr11_124927411_- | intronic |
| ADediting_241281 | chr11_124927428_- | intronic |
| ADediting_241282 | chr11_124927475_- | intronic |
| ADediting_241283 | chr11_124927489_- | intronic |
| ADediting_241284 | chr11_124927665_- | intronic |
| ADediting_241285 | chr11_124927711_- | intronic |
| ADediting_241286 | chr11_124927769_- | intronic |
| ADediting_241287 | chr11_124927775_- | intronic |
| ADediting_241288 | chr11_124927815_- | intronic |
| ADediting_241289 | chr11_124927822_- | intronic |
| ADediting_241290 | chr11_124927839_- | intronic |
| ADediting_241297 | chr11_124933348_- | intronic |
| ADediting_241298 | chr11_124934474_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_241257 | chr11_124925944_- | SINE | Alu | Name=AluSx |
| ADediting_241258 | chr11_124925956_- | SINE | Alu | Name=AluSx |
| ADediting_241259 | chr11_124925957_- | SINE | Alu | Name=AluSx |
| ADediting_241260 | chr11_124926009_- | SINE | Alu | Name=AluSx |
| ADediting_241261 | chr11_124926018_- | SINE | Alu | Name=AluSx |
| ADediting_241262 | chr11_124926074_- | SINE | Alu | Name=AluSx |
| ADediting_241263 | chr11_124926078_- | SINE | Alu | Name=AluSx |
| ADediting_241264 | chr11_124926080_- | SINE | Alu | Name=AluSx |
| ADediting_241265 | chr11_124926090_- | SINE | Alu | Name=AluSx |
| ADediting_241266 | chr11_124926119_- | SINE | Alu | Name=AluSx |
| ADediting_241267 | chr11_124926155_- | SINE | Alu | Name=AluSx |
| ADediting_241268 | chr11_124926161_- | SINE | Alu | Name=AluSx |
| ADediting_241269 | chr11_124926168_- | SINE | Alu | Name=AluSx |
| ADediting_241270 | chr11_124926169_- | SINE | Alu | Name=AluSx |
| ADediting_241271 | chr11_124926901_- | SINE | Alu | Name=AluY |
| ADediting_241272 | chr11_124926907_- | SINE | Alu | Name=AluY |
| ADediting_241273 | chr11_124926926_- | SINE | Alu | Name=AluY |
| ADediting_241274 | chr11_124926993_- | SINE | Alu | Name=AluY |
| ADediting_241275 | chr11_124927006_- | SINE | Alu | Name=AluY |
| ADediting_241276 | chr11_124927054_- | SINE | Alu | Name=AluY |
| ADediting_241277 | chr11_124927075_- | SINE | Alu | Name=AluY |
| ADediting_241278 | chr11_124927104_- | SINE | Alu | Name=AluY |
| ADediting_241279 | chr11_124927410_- | SINE | Alu | Name=AluJb |
| ADediting_241280 | chr11_124927411_- | SINE | Alu | Name=AluJb |
| ADediting_241281 | chr11_124927428_- | SINE | Alu | Name=AluJb |
| ADediting_241282 | chr11_124927475_- | SINE | Alu | Name=AluJb |
| ADediting_241283 | chr11_124927489_- | SINE | Alu | Name=AluJb |
| ADediting_241286 | chr11_124927769_- | SINE | Alu | Name=AluSc8 |
| ADediting_241287 | chr11_124927775_- | SINE | Alu | Name=AluSc8 |
| ADediting_241288 | chr11_124927815_- | SINE | Alu | Name=AluSc8 |
| ADediting_241289 | chr11_124927822_- | SINE | Alu | Name=AluSc8 |
| ADediting_241290 | chr11_124927839_- | SINE | Alu | Name=AluSc8 |
| ADediting_241297 | chr11_124933348_- | SINE | Alu | Name=AluJb |
| ADediting_241298 | chr11_124934474_- | LTR | ERVL-MaLR | Name=MLT1C |
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RNA A-to-I editing events in the alternative splicing sites for HEPACAM |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for HEPACAM |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for HEPACAM |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for HEPACAM |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000165478.7 | ENST00000298251.5 | HEPACAM-201 | hsa-miR-4477b | chr11 | 124920018 | 124920024 | 7mer-m8 | 124920017 | 124920037 | 149 | -14.02 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000165478.7 | ENST00000298251.5 | HEPACAM-201 | hsa-miR-381-3p | chr11 | 124919823 | 124919829 | 7mer-m8 | 124919822 | 124919843 | 151 | -16.6 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000165478.7 | ENST00000298251.5 | HEPACAM-201 | hsa-miR-5682 | chr11 | 124920466 | 124920472 | 7mer-m8 | 124920465 | 124920491 | 150 | -22.71 |
| ADediting_286380 | chr11_79422188_- | ENSG00000165478.7 | ENST00000298251.5 | HEPACAM-201 | hsa-miR-5579-3p | chr11 | 124919390 | 124919397 | 8mer-1a | 124919390 | 124919411 | 150 | -15.18 |
| ADediting_496066 | chr15_66496985_- | ENSG00000165478.7 | ENST00000298251.5 | HEPACAM-201 | hsa-miR-4512 | chr11 | 124919760 | 124919767 | 8mer-1a | 124919760 | 124919781 | 140 | -19.71 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000165478.7 | ENST00000298251.5 | HEPACAM-201 | hsa-miR-5688 | chr11 | 124919338 | 124919344 | 7mer-m8 | 124919337 | 124919358 | 147 | -11.47 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000165478.7 | ENST00000298251.5 | HEPACAM-201 | hsa-miR-589-3p | chr11 | 124920579 | 124920586 | 8mer-1a | 124920579 | 124920603 | 149 | -25.59 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000165478.7 | ENST00000298251.5 | HEPACAM-201 | hsa-miR-4477b | chr11 | 124919844 | 124919850 | 7mer-m8 | 124919843 | 124919864 | 140 | -8.39 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000165478.7 | ENST00000298251.5 | HEPACAM-201 | hsa-miR-4477b | chr11 | 124919844 | 124919850 | 7mer-m8 | 124919843 | 124919864 | 140 | -8.39 |
| ADediting_286380 | chr11_79422188_- | ENSG00000165478.7 | ENST00000298251.5 | HEPACAM-201 | hsa-miR-5579-3p | chr11 | 124920624 | 124920631 | 8mer-1a | 124920624 | 124920643 | 144 | -11.5 |
| ADediting_496066 | chr15_66496985_- | ENSG00000165478.7 | ENST00000298251.5 | HEPACAM-201 | hsa-miR-4512 | chr11 | 124919871 | 124919877 | 7mer-m8 | 124919870 | 124919893 | 151 | -21.09 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for HEPACAM |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for HEPACAM |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| TCX | ADediting_241258 | chr11_124925956_- | 0.39804938492708 | 0.0695008656500557 | 0.759783140085625 | -0.0251722756187632 | 0.000116557282258773 | 0.309447735342992 |
| DLPFC | ADediting_241264 | chr11_124926080_- | 0.347717752039846 | 0.0535110041021414 | 0.841968554279034 | 0.011369365053202 | 3.16502928860806e-08 | 0.307783054574625 |
| TCX | ADediting_241264 | chr11_124926080_- | 0.793853662243756 | -0.0215133497654055 | 0.160149338725756 | -0.115264243942441 | 2.91907967858661e-05 | 0.334200785436443 |
| FP | ADediting_241264 | chr11_124926080_- | 0.97075949490437 | -0.00276695300489697 | 0.258007627982177 | -0.0852265798758839 | 2.95430304306962e-06 | 0.342109965361272 |
| TCX | ADediting_241268 | chr11_124926161_- | 0.261462870204871 | 0.0922637979635618 | 0.806787034734666 | -0.0201357256600065 | 0.000175678993703729 | 0.301676037980778 |
| DLPFC | ADediting_241285 | chr11_124927711_- | 0.358713764773456 | 0.0523042079826534 | 0.464623457970554 | -0.0416828231876235 | 5.68097741334773e-10 | 0.342744776314713 |
| TCX | ADediting_241285 | chr11_124927711_- | 0.495194898268891 | -0.0561162878733072 | 0.0070541882792244 | -0.21913932599954 | 2.68815670388855e-05 | 0.335608905152137 |
| TCX | ADediting_241289 | chr11_124927822_- | 0.0015670488366034 | -0.255999308698651 | 1.0224907809678e-05 | -0.351635762068676 | 9.12973344296923e-05 | 0.313974321512371 |
| PG | ADediting_241289 | chr11_124927822_- | 0.126849266746441 | -0.11234173099964 | 0.0750193309920683 | -0.130861548253974 | 6.44246605982786e-06 | 0.324003180605666 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 6.94630746456843e-12 | 0.376634438937419 | 0.0368909566159406 | 0.118592348358368 | 4.88296841254436e-86 | 0.845795561149869 |
| AC | 3.60253493145307e-26 | 0.6032542792466 | 5.71544529412028e-12 | 0.417576648189148 | 2.30476916517385e-49 | 0.765328651811699 |
| PCC | 0.0105168830666511 | 0.184732632763469 | 0.640406678720476 | 0.0340138537038774 | 4.75437459278123e-23 | 0.636066795006308 |
| CER | 7.27910324017178e-08 | 0.42239547801572 | 0.0234960530681264 | 0.184907515801731 | 1.78700734402456e-17 | 0.622664641122074 |
| TCX | 2.29643627531843e-06 | 0.374804736349082 | 0.202002870322506 | -0.104763506607874 | 6.35861401996668e-20 | 0.657440571847783 |
| FP | 0.0114823022258861 | 0.189076709992673 | 0.25445062370305 | -0.0858641413706993 | 2.57146040808307e-22 | 0.644978385578518 |
| IFG | 0.00955335453737579 | 0.507834722976969 | 0.0600302700704259 | 0.381284134766422 | 2.50312862251373e-06 | 0.791097343228422 |
| PG | 0.0692802378044517 | 0.133501789090829 | 0.010127069088546 | -0.188130202368609 | 7.48944775122959e-19 | 0.590328696046645 |
| STG | 0.0333481326968348 | 0.232461833982365 | 0.205408051452185 | -0.139577903876687 | 1.3752033807781e-10 | 0.629852729959397 |
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Relation with AD stages for HEPACAM |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 3.06500013396871e-05 | 0.38968078872201 |
| TCX | 1.15090932236893e-10 | 0.574963177825471 |
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RelatedDrugs for HEPACAM |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HEPACAM |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| HEPACAM | C3151355 | MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS 2A | 1 | UNIPROT |
| HEPACAM | C3151356 | MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS 2B, REMITTING, WITH OR WITHOUT MENTAL RETARDATION | 1 | CTD_human;UNIPROT |
| HEPACAM | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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