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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for LRRC55 |
 Gene summary |
| Gene information | Gene symbol | LRRC55 | Gene ID | 219527 |
| Gene name | leucine rich repeat containing 55 | |
| Synonyms | - | |
| Cytomap | 11q12.1 | |
| Type of gene | protein-coding | |
| Description | leucine-rich repeat-containing protein 55BK channel auxiliary gamma subunit LRRC55BK channel auxilliary gamma snit LRRC55 | |
| Modification date | 20200313 | |
| UniProtAcc | Q6ZSA7, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| LRRC55 | GO:0071805 | potassium ion transmembrane transport | 22547800 |
| LRRC55 | GO:1903818 | positive regulation of voltage-gated potassium channel activity | 22547800 |
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RNA A-to-I events for LRRC55 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_258515(57190786, +), |
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RNA editing positional annotations for LRRC55 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_258515 | chr11_57190786_+ | UTR3 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_258515 | chr11_57190786_+ | DNA | TcMar-Mariner | Name=MADE1 |
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RNA A-to-I editing events in the alternative splicing sites for LRRC55 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for LRRC55 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for LRRC55 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for LRRC55 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_258515 | chr11_57190786_+ | ENSG00000183908.7 | ENST00000497933.3 | LRRC55-201 | hsa-miR-4776-3p | chr11 | 57190783 | 57190790 | 8mer-1a | 57190768 | 57190790 | 149 | -12.29 |
| ADediting_258515 | chr11_57190786_+ | ENSG00000183908.7 | ENST00000652194.1 | LRRC55-202 | hsa-miR-4776-3p | chr11 | 57190783 | 57190790 | 8mer-1a | 57190768 | 57190790 | 149 | -12.29 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000183908.7 | ENST00000497933.3 | LRRC55-201 | hsa-miR-5688 | chr11 | 57191490 | 57191497 | 8mer-1a | 57191476 | 57191497 | 150 | -15.97 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000183908.7 | ENST00000652194.1 | LRRC55-202 | hsa-miR-5688 | chr11 | 57191490 | 57191497 | 8mer-1a | 57191476 | 57191497 | 150 | -15.97 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000183908.7 | ENST00000497933.3 | LRRC55-201 | hsa-miR-151a-3p | chr11 | 57189685 | 57189692 | 8mer-1a | 57189675 | 57189692 | 150 | -18.87 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000183908.7 | ENST00000652194.1 | LRRC55-202 | hsa-miR-151a-3p | chr11 | 57189685 | 57189692 | 8mer-1a | 57189675 | 57189692 | 150 | -18.87 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000183908.7 | ENST00000497933.3 | LRRC55-201 | hsa-miR-4477b | chr11 | 57191377 | 57191384 | 8mer-1a | 57191364 | 57191384 | 147 | -11.63 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000183908.7 | ENST00000652194.1 | LRRC55-202 | hsa-miR-4477b | chr11 | 57191377 | 57191384 | 8mer-1a | 57191364 | 57191384 | 147 | -11.63 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000183908.7 | ENST00000497933.3 | LRRC55-201 | hsa-miR-641 | chr11 | 57190258 | 57190264 | 7mer-m8 | 57190246 | 57190265 | 146 | -15.6 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000183908.7 | ENST00000652194.1 | LRRC55-202 | hsa-miR-641 | chr11 | 57190258 | 57190264 | 7mer-m8 | 57190246 | 57190265 | 146 | -15.6 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000183908.7 | ENST00000497933.3 | LRRC55-201 | hsa-miR-4775 | chr11 | 57188999 | 57189006 | 8mer-1a | 57188985 | 57189006 | 149 | -8.3 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000183908.7 | ENST00000652194.1 | LRRC55-202 | hsa-miR-4775 | chr11 | 57188999 | 57189006 | 8mer-1a | 57188985 | 57189006 | 149 | -8.3 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000183908.7 | ENST00000497933.3 | LRRC55-201 | hsa-miR-5585-3p | chr11 | 57188965 | 57188971 | 7mer-m8 | 57188951 | 57188972 | 152 | -21.01 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000183908.7 | ENST00000652194.1 | LRRC55-202 | hsa-miR-5585-3p | chr11 | 57188965 | 57188971 | 7mer-m8 | 57188951 | 57188972 | 152 | -21.01 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000183908.7 | ENST00000497933.3 | LRRC55-201 | hsa-miR-381-3p | chr11 | 57187975 | 57187982 | 8mer-1a | 57187961 | 57187982 | 140 | -11.29 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000183908.7 | ENST00000652194.1 | LRRC55-202 | hsa-miR-381-3p | chr11 | 57187975 | 57187982 | 8mer-1a | 57187961 | 57187982 | 140 | -11.29 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000183908.7 | ENST00000497933.3 | LRRC55-201 | hsa-miR-381-3p | chr11 | 57187975 | 57187982 | 8mer-1a | 57187961 | 57187982 | 140 | -11.29 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000183908.7 | ENST00000652194.1 | LRRC55-202 | hsa-miR-381-3p | chr11 | 57187975 | 57187982 | 8mer-1a | 57187961 | 57187982 | 140 | -11.29 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000183908.7 | ENST00000497933.3 | LRRC55-201 | hsa-miR-5682 | chr11 | 57191560 | 57191566 | 7mer-1a | 57191545 | 57191566 | 150 | -25.28 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000183908.7 | ENST00000652194.1 | LRRC55-202 | hsa-miR-5682 | chr11 | 57191560 | 57191566 | 7mer-1a | 57191545 | 57191566 | 150 | -25.28 |
| ADediting_286380 | chr11_79422188_- | ENSG00000183908.7 | ENST00000497933.3 | LRRC55-201 | hsa-miR-5579-3p | chr11 | 57189364 | 57189371 | 8mer-1a | 57189350 | 57189371 | 152 | -12.47 |
| ADediting_286380 | chr11_79422188_- | ENSG00000183908.7 | ENST00000652194.1 | LRRC55-202 | hsa-miR-5579-3p | chr11 | 57189364 | 57189371 | 8mer-1a | 57189350 | 57189371 | 152 | -12.47 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000183908.7 | ENST00000497933.3 | LRRC55-201 | hsa-miR-1273h-3p | chr11 | 57187902 | 57187908 | 7mer-m8 | 57187890 | 57187909 | 146 | -14.84 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000183908.7 | ENST00000652194.1 | LRRC55-202 | hsa-miR-1273h-3p | chr11 | 57187902 | 57187908 | 7mer-m8 | 57187890 | 57187909 | 146 | -14.84 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for LRRC55 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000652194.1 | protein_coding |  |  |
| ENST00000497933.3 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_258515 | ENST00000652194.1 | chr11_57190786_+ | 4479 | -1826.20 | -1819.60 | -1826.20 |
| ADediting_258515 | ENST00000497933.3 | chr11_57190786_+ | 4273 | -1741.80 | -1735.20 | -1741.80 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for LRRC55 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| TCX | ADediting_258515 | chr11_57190786_+ | 1.07384441740959e-06 | 0.385942744290701 | 0.00334434537396005 | 0.238110736209768 | 0.992468997662125 | -0.00077718041217163 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 6.39566567239987e-24 | 0.53069530479521 | 1.01285782779899e-14 | 0.420613686082292 | 0.155526761286783 | -0.0808608819010183 |
| AC | 2.08373097559334e-21 | 0.552794817874004 | 9.91680794279433e-12 | 0.413231125028229 | 0.125086488213338 | 0.0972613770856436 |
| PCC | 8.47735329744149e-13 | 0.487558880707662 | 1.97077481929319e-07 | 0.36568992599031 | 0.982330022699256 | -0.00161314984465708 |
| TCX | 6.77100763244882e-30 | 0.763464932417938 | 2.94164492277674e-14 | 0.569254122330356 | 0.766829420514543 | 0.0244117456249474 |
| FP | 2.77416045480752e-20 | 0.619967771734118 | 5.21064025044191e-12 | 0.487408894582832 | 0.00100356790876312 | 0.244529132775188 |
| IFG | 0.000483631936504809 | 0.64620319333166 | 0.0381389166093237 | 0.416918621338306 | 0.058921970919101 | 0.38281898738075 |
| PG | 2.67499468302099e-34 | 0.745850381087507 | 1.69883267882253e-21 | 0.624378830669598 | 0.0699115866678799 | 0.133202820449087 |
| STG | 8.33931512777756e-06 | 0.46499477903883 | 5.14581386954922e-06 | 0.474395944592772 | 0.260671703512266 | 0.124110736771044 |
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Relation with AD stages for LRRC55 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 0.000542791971114869 | 0.327401154881676 |
| TCX | 4.8129270046972e-05 | 0.384083120607203 |
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RelatedDrugs for LRRC55 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LRRC55 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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