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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for ERCC4 |
 Gene summary |
| Gene information | Gene symbol | ERCC4 | Gene ID | 2072 |
| Gene name | ERCC excision repair 4, endonuclease catalytic subunit | |
| Synonyms | ERCC11|FANCQ|RAD1|XFEPS|XPF | |
| Cytomap | 16p13.12 | |
| Type of gene | protein-coding | |
| Description | DNA repair endonuclease XPFDNA excision repair protein ERCC-4DNA repair protein complementing XP-F cellsexcision repair cross-complementation group 4excision repair cross-complementing rodent repair deficiency, complementation group 4excision-repair, | |
| Modification date | 20200315 | |
| UniProtAcc | Q92889, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ERCC4 | GO:0006289 | nucleotide-excision repair | 10644440 |
| ERCC4 | GO:0033683 | nucleotide-excision repair, DNA incision | 10413517 |
| ERCC4 | GO:0051974 | negative regulation of telomerase activity | 18812185 |
| ERCC4 | GO:1904357 | negative regulation of telomere maintenance via telomere lengthening | 18812185 |
| ERCC4 | GO:1905768 | negative regulation of double-stranded telomeric DNA binding | 18812185 |
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RNA A-to-I events for ERCC4 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_518493(13948558, +), ADediting_518494(13948576, +), ADediting_518495(13948591, +), ADediting_518496(13948592, +), ADediting_518497(13948593, +), ADediting_518498(13948645, +), ADediting_518499(13948652, +), ADediting_518500(13948662, +), ADediting_518501(13948672, +), ADediting_518502(13948676, +), ADediting_518503(13948680, +), ADediting_518504(13948691, +), ADediting_518505(13948692, +), ADediting_518506(13948700, +), ADediting_518507(13948711, +), ADediting_518508(13948721, +), ADediting_518509(13948734, +), ADediting_518510(13949347, +), ADediting_518511(13949359, +), ADediting_518512(13949985, +), ADediting_518513(13950025, +), ADediting_1541044(13948639, +), ADediting_1541045(13948643, +), |
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RNA editing positional annotations for ERCC4 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_518493 | chr16_13948558_+ | UTR3 |
| ADediting_518494 | chr16_13948576_+ | UTR3 |
| ADediting_518495 | chr16_13948591_+ | UTR3 |
| ADediting_518496 | chr16_13948592_+ | UTR3 |
| ADediting_518497 | chr16_13948593_+ | UTR3 |
| ADediting_518498 | chr16_13948645_+ | UTR3 |
| ADediting_518499 | chr16_13948652_+ | UTR3 |
| ADediting_518500 | chr16_13948662_+ | UTR3 |
| ADediting_518501 | chr16_13948672_+ | UTR3 |
| ADediting_518502 | chr16_13948676_+ | UTR3 |
| ADediting_518503 | chr16_13948680_+ | UTR3 |
| ADediting_518504 | chr16_13948691_+ | UTR3 |
| ADediting_518505 | chr16_13948692_+ | UTR3 |
| ADediting_518506 | chr16_13948700_+ | UTR3 |
| ADediting_518507 | chr16_13948711_+ | UTR3 |
| ADediting_518508 | chr16_13948721_+ | UTR3 |
| ADediting_518509 | chr16_13948734_+ | UTR3 |
| ADediting_518510 | chr16_13949347_+ | UTR3 |
| ADediting_518511 | chr16_13949359_+ | UTR3 |
| ADediting_518512 | chr16_13949985_+ | UTR3 |
| ADediting_518513 | chr16_13950025_+ | UTR3 |
| ADediting_1541044 | chr16_13948639_+ | UTR3 |
| ADediting_1541045 | chr16_13948643_+ | UTR3 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_518510 | chr16_13949347_+ | SINE | Alu | Name=AluSz6 |
| ADediting_518511 | chr16_13949359_+ | SINE | Alu | Name=AluSz6 |
| ADediting_518512 | chr16_13949985_+ | SINE | Alu | Name=AluSx |
| ADediting_518513 | chr16_13950025_+ | SINE | Alu | Name=AluSx |
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RNA A-to-I editing events in the alternative splicing sites for ERCC4 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ERCC4 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for ERCC4 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for ERCC4 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1541044 | chr16_13948639_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-2276-5p | chr16 | 13948634 | 13948640 | 7mer-m8 | 13948618 | 13948641 | 161 | -21.46 |
| ADediting_1541044 | chr16_13948639_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-7848-3p | chr16 | 13948636 | 13948642 | 7mer-m8 | 13948619 | 13948643 | 148 | -19.48 |
| ADediting_518498 | chr16_13948645_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-3685 | chr16 | 13948640 | 13948646 | 7mer-m8 | 13948628 | 13948647 | 152 | -14.9 |
| ADediting_518499 | chr16_13948652_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-4742-5p | chr16 | 13948649 | 13948656 | 8mer-1a | 13948637 | 13948656 | 156 | -20.43 |
| ADediting_518503 | chr16_13948680_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-3938 | chr16 | 13948678 | 13948685 | 8mer-1a | 13948664 | 13948685 | 165 | -15.19 |
| ADediting_518503 | chr16_13948680_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-4755-5p | chr16 | 13948677 | 13948683 | 7mer-m8 | 13948663 | 13948684 | 149 | -15.06 |
| ADediting_518503 | chr16_13948680_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-5006-3p | chr16 | 13948677 | 13948683 | 7mer-m8 | 13948664 | 13948684 | 141 | -10.58 |
| ADediting_518503 | chr16_13948680_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-5088-3p | chr16 | 13948675 | 13948682 | 8mer-1a | 13948662 | 13948682 | 151 | -18.58 |
| ADediting_518504 | chr16_13948691_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-24-3p | chr16 | 13948688 | 13948694 | 7mer-m8 | 13948674 | 13948695 | 141 | -13.33 |
| ADediting_518505 | chr16_13948692_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-4650-5p | chr16 | 13948690 | 13948696 | 7mer-m8 | 13948679 | 13948697 | 140 | -16.44 |
| ADediting_518508 | chr16_13948721_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-1236-3p | chr16 | 13948716 | 13948723 | 8mer-1a | 13948699 | 13948723 | 158 | -25.52 |
| ADediting_518509 | chr16_13948734_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-1914-5p | chr16 | 13948728 | 13948735 | 8mer-1a | 13948715 | 13948735 | 154 | -20.34 |
| ADediting_518509 | chr16_13948734_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-3124-3p | chr16 | 13948732 | 13948738 | 7mer-m8 | 13948718 | 13948739 | 140 | -11.71 |
| ADediting_518509 | chr16_13948734_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-6529-3p | chr16 | 13948727 | 13948733 | 7mer-m8 | 13948712 | 13948734 | 159 | -23.49 |
| ADediting_518509 | chr16_13948734_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-6889-3p | chr16 | 13948727 | 13948733 | 7mer-m8 | 13948713 | 13948734 | 149 | -23.41 |
| ADediting_518509 | chr16_13948734_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-7152-5p | chr16 | 13948730 | 13948737 | 8mer-1a | 13948715 | 13948737 | 148 | -16.27 |
| ADediting_518510 | chr16_13949347_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-324-3p | chr16 | 13949340 | 13949346 | 7mer-m8 | 13949323 | 13949347 | 148 | -24.67 |
| ADediting_518510 | chr16_13949347_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-6075 | chr16 | 13949344 | 13949351 | 8mer-1a | 13949331 | 13949351 | 148 | -21.27 |
| ADediting_518511 | chr16_13949359_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-4634 | chr16 | 13949354 | 13949361 | 8mer-1a | 13949341 | 13949361 | 150 | -24.65 |
| ADediting_518512 | chr16_13949985_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-340-3p | chr16 | 13949979 | 13949986 | 8mer-1a | 13949965 | 13949986 | 146 | -21.36 |
| ADediting_518512 | chr16_13949985_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-6827-3p | chr16 | 13949979 | 13949986 | 8mer-1a | 13949966 | 13949986 | 140 | -14.67 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1541044 | chr16_13948639_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-1237-3p | chr16 | 13948634 | 13948640 | 7mer-m8 | 13948621 | 13948641 | 140 | -12.49 |
| ADediting_1541044 | chr16_13948639_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-3182 | chr16 | 13948633 | 13948639 | 7mer-m8 | 13948624 | 13948640 | 151 | -13.31 |
| ADediting_1541044 | chr16_13948639_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-4724-3p | chr16 | 13948636 | 13948642 | 7mer-m8 | 13948623 | 13948643 | 155 | -18.42 |
| ADediting_1541045 | chr16_13948643_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-4724-3p | chr16 | 13948636 | 13948642 | 7mer-m8 | 13948623 | 13948643 | 155 | -18.42 |
| ADediting_518494 | chr16_13948576_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-4639-5p | chr16 | 13948572 | 13948578 | 7mer-m8 | 13948557 | 13948579 | 154 | -19.31 |
| ADediting_518501 | chr16_13948672_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-1252-3p | chr16 | 13948668 | 13948675 | 8mer-1a | 13948654 | 13948675 | 147 | -6.31 |
| ADediting_518501 | chr16_13948672_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-190b-3p | chr16 | 13948670 | 13948677 | 8mer-1a | 13948657 | 13948677 | 140 | -6.58 |
| ADediting_518502 | chr16_13948676_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-190b-3p | chr16 | 13948670 | 13948677 | 8mer-1a | 13948657 | 13948677 | 140 | -6.58 |
| ADediting_518502 | chr16_13948676_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-4799-5p | chr16 | 13948671 | 13948678 | 8mer-1a | 13948657 | 13948678 | 148 | -10.64 |
| ADediting_518506 | chr16_13948700_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-5006-5p | chr16 | 13948693 | 13948699 | 7mer-m8 | 13948680 | 13948700 | 140 | -13.75 |
| ADediting_518506 | chr16_13948700_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-5581-3p | chr16 | 13948697 | 13948703 | 7mer-m8 | 13948680 | 13948704 | 150 | -19.93 |
| ADediting_518506 | chr16_13948700_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-6872-3p | chr16 | 13948696 | 13948703 | 8mer-1a | 13948683 | 13948703 | 140 | -16.39 |
| ADediting_518507 | chr16_13948711_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-3130-3p | chr16 | 13948705 | 13948711 | 7mer-m8 | 13948690 | 13948712 | 146 | -23.5 |
| ADediting_518508 | chr16_13948721_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-4446-5p | chr16 | 13948714 | 13948721 | 8mer-1a | 13948700 | 13948721 | 151 | -19.04 |
| ADediting_518509 | chr16_13948734_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-578 | chr16 | 13948730 | 13948737 | 8mer-1a | 13948717 | 13948737 | 151 | -13.73 |
| ADediting_518510 | chr16_13949347_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-1304-3p | chr16 | 13949341 | 13949347 | 7mer-m8 | 13949327 | 13949348 | 141 | -12.09 |
| ADediting_518510 | chr16_13949347_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-4284 | chr16 | 13949343 | 13949349 | 7mer-m8 | 13949333 | 13949350 | 140 | -12.9 |
| ADediting_518511 | chr16_13949359_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-675-5p | chr16 | 13949355 | 13949361 | 7mer-1a | 13949339 | 13949361 | 141 | -23.91 |
| ADediting_518512 | chr16_13949985_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-3664-5p | chr16 | 13949982 | 13949988 | 7mer-m8 | 13949968 | 13949989 | 153 | -15.28 |
| ADediting_518512 | chr16_13949985_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-4522 | chr16 | 13949983 | 13949989 | 7mer-m8 | 13949970 | 13949990 | 148 | -12.83 |
| ADediting_518512 | chr16_13949985_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-6888-3p | chr16 | 13949980 | 13949986 | 7mer-m8 | 13949967 | 13949987 | 151 | -14.42 |
| ADediting_518513 | chr16_13950025_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-5186 | chr16 | 13950023 | 13950029 | 7mer-m8 | 13950010 | 13950030 | 140 | -10.42 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-5688 | chr16 | 13948597 | 13948604 | 8mer-1a | 13948582 | 13948604 | 157 | -14.75 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-4477b | chr16 | 13949051 | 13949058 | 8mer-1a | 13949039 | 13949058 | 152 | -15.55 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-4477b | chr16 | 13949232 | 13949238 | 7mer-m8 | 13949218 | 13949239 | 160 | -14.52 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-641 | chr16 | 13950661 | 13950667 | 7mer-m8 | 13950646 | 13950668 | 154 | -16.89 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000175595.14 | ENST00000575156.5 | ERCC4-207 | hsa-miR-641 | chr16 | 13933213 | 13933219 | 7mer-1a | 13933193 | 13933219 | 144 | -23.93 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-641 | chr16 | 13948806 | 13948812 | 7mer-m8 | 13948789 | 13948813 | 160 | -15.52 |
| ADediting_286380 | chr11_79422188_- | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-5579-3p | chr16 | 13951926 | 13951932 | 7mer-m8 | 13951912 | 13951933 | 145 | -13.4 |
| ADediting_286380 | chr11_79422188_- | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-5579-3p | chr16 | 13952095 | 13952102 | 8mer-1a | 13952081 | 13952102 | 140 | -12.48 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_107020 | chr1_37500952_- | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-5581-3p | chr16 | 13948697 | 13948703 | 7mer-m8 | 13948680 | 13948704 | 150 | -19.93 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000175595.14 | ENST00000575156.5 | ERCC4-207 | hsa-miR-5688 | chr16 | 13932412 | 13932419 | 8mer-1a | 13932398 | 13932419 | 153 | -11.84 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-589-3p | chr16 | 13948884 | 13948891 | 8mer-1a | 13948872 | 13948891 | 144 | -15.08 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000175595.14 | ENST00000575156.5 | ERCC4-207 | hsa-miR-151a-3p | chr16 | 13932504 | 13932510 | 7mer-m8 | 13932487 | 13932511 | 151 | -15.31 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-381-3p | chr16 | 13950721 | 13950728 | 8mer-1a | 13950707 | 13950728 | 154 | -12.87 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-381-3p | chr16 | 13950721 | 13950728 | 8mer-1a | 13950707 | 13950728 | 154 | -12.87 |
| ADediting_286380 | chr11_79422188_- | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-5579-3p | chr16 | 13951512 | 13951518 | 7mer-m8 | 13951498 | 13951519 | 140 | -11.46 |
| ADediting_291761 | chr11_93733708_- | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-1304-3p | chr16 | 13949341 | 13949347 | 7mer-m8 | 13949327 | 13949348 | 141 | -12.09 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-4775 | chr16 | 13951218 | 13951225 | 8mer-1a | 13951203 | 13951225 | 143 | -5.36 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000175595.14 | ENST00000311895.7 | ERCC4-201 | hsa-miR-4775 | chr16 | 13951921 | 13951928 | 8mer-1a | 13951905 | 13951928 | 149 | -11.06 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000175595.14 | ENST00000575156.5 | ERCC4-207 | hsa-miR-4775 | chr16 | 13932892 | 13932898 | 7mer-m8 | 13932878 | 13932899 | 154 | -5.7 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for ERCC4 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000311895.7 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_518493 | ENST00000311895.7 | chr16_13948558_+ | 2971 | -1912.20 | -1912.60 | -1932.60 |
| ADediting_518494 | ENST00000311895.7 | chr16_13948576_+ | 2989 | -1912.30 | -1912.60 | -1932.60 |
| ADediting_518495 | ENST00000311895.7 | chr16_13948591_+ | 3004 | -1912.70 | -1912.60 | -1932.60 |
| ADediting_518496 | ENST00000311895.7 | chr16_13948592_+ | 3005 | -1912.70 | -1912.60 | -1932.60 |
| ADediting_518497 | ENST00000311895.7 | chr16_13948593_+ | 3006 | -1912.60 | -1912.60 | -1932.60 |
| ADediting_1541044 | ENST00000311895.7 | chr16_13948639_+ | 3052 | -1912.60 | -1912.60 | -1932.60 |
| ADediting_1541045 | ENST00000311895.7 | chr16_13948643_+ | 3056 | -1912.30 | -1912.60 | -1932.60 |
| ADediting_518498 | ENST00000311895.7 | chr16_13948645_+ | 3058 | -1919.50 | -1912.60 | -1932.60 |
| ADediting_518499 | ENST00000311895.7 | chr16_13948652_+ | 3065 | -1912.60 | -1912.60 | -1932.60 |
| ADediting_518500 | ENST00000311895.7 | chr16_13948662_+ | 3075 | -1919.00 | -1912.60 | -1932.60 |
| ADediting_518501 | ENST00000311895.7 | chr16_13948672_+ | 3085 | -1912.20 | -1912.60 | -1932.60 |
| ADediting_518502 | ENST00000311895.7 | chr16_13948676_+ | 3089 | -1912.20 | -1912.60 | -1932.60 |
| ADediting_518503 | ENST00000311895.7 | chr16_13948680_+ | 3093 | -1912.30 | -1912.60 | -1932.60 |
| ADediting_518504 | ENST00000311895.7 | chr16_13948691_+ | 3104 | -1912.70 | -1912.60 | -1932.60 |
| ADediting_518505 | ENST00000311895.7 | chr16_13948692_+ | 3105 | -1912.30 | -1912.60 | -1932.60 |
| ADediting_518506 | ENST00000311895.7 | chr16_13948700_+ | 3113 | -1912.20 | -1912.60 | -1932.60 |
| ADediting_518507 | ENST00000311895.7 | chr16_13948711_+ | 3124 | -1911.90 | -1912.60 | -1932.60 |
| ADediting_518508 | ENST00000311895.7 | chr16_13948721_+ | 3134 | -1912.70 | -1912.60 | -1932.60 |
| ADediting_518509 | ENST00000311895.7 | chr16_13948734_+ | 3147 | -1919.20 | -1912.60 | -1932.60 |
| ADediting_518510 | ENST00000311895.7 | chr16_13949347_+ | 3760 | -1911.70 | -1912.60 | -1932.60 |
| ADediting_518511 | ENST00000311895.7 | chr16_13949359_+ | 3772 | -1918.00 | -1912.60 | -1932.60 |
| ADediting_518512 | ENST00000311895.7 | chr16_13949985_+ | 4398 | -1911.80 | -1912.60 | -1932.60 |
| ADediting_518513 | ENST00000311895.7 | chr16_13950025_+ | 4438 | -1918.60 | -1912.60 | -1932.60 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for ERCC4 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| TCX | ADediting_518493 | chr16_13948558_+ | 3.82447994691253e-07 | 0.400443778412258 | 0.000113328430401196 | 0.309972067178977 | 0.621613562011063 | -0.0406225828773269 |
| CER | ADediting_518494 | chr16_13948576_+ | 2.45111764178212e-06 | 0.373830119442286 | 0.00147056960596984 | 0.257443161579516 | 0.430696041361454 | 0.0648145362121128 |
| TCX | ADediting_518494 | chr16_13948576_+ | 1.34753090705367e-05 | 0.34714786315516 | 0.776245672730802 | 0.0233986145473214 | 2.83117959697646e-06 | 0.371663585140166 |
| CER | ADediting_518495 | chr16_13948591_+ | 9.11068602271877e-08 | 0.419515773116029 | 0.000670227064693347 | 0.274665923234114 | 0.389710569112244 | 0.0707340315781826 |
| CER | ADediting_518496 | chr16_13948592_+ | 4.70419861934061e-10 | 0.480896776698676 | 1.18263859679884e-05 | 0.349278571959351 | 0.304024556070999 | 0.0844794589292983 |
| CER | ADediting_518497 | chr16_13948593_+ | 1.34471548128932e-07 | 0.414455840170305 | 0.00397123290569864 | 0.233872550892794 | 0.728600321292228 | -0.028564626487006 |
| CER | ADediting_518502 | chr16_13948676_+ | 5.21854515757659e-06 | 0.362293996005552 | 0.00249845406656214 | 0.245142594090685 | 0.217340615519992 | 0.101313651688986 |
| CER | ADediting_518503 | chr16_13948680_+ | 6.27151344752952e-07 | 0.393582915855004 | 0.000902777879804168 | 0.268269859987235 | 0.385335194861411 | 0.0713874247566858 |
| CER | ADediting_518504 | chr16_13948691_+ | 1.87682980692711e-09 | 0.465906734672126 | 0.000402725206060826 | 0.285260133304095 | 0.299545920557921 | 0.0852628862812318 |
| TCX | ADediting_518504 | chr16_13948691_+ | 1.59971527044138e-05 | 0.344323697182786 | 0.128742421616813 | 0.124590802024004 | 0.00359045868974288 | 0.236367861616246 |
| CER | ADediting_518505 | chr16_13948692_+ | 5.67402384594612e-09 | 0.453378780832949 | 0.000747520526714246 | 0.272340113506221 | 0.153438985285429 | 0.117132243467737 |
| TCX | ADediting_518505 | chr16_13948692_+ | 1.20297318881797e-05 | 0.349001154075241 | 0.0347117642776262 | 0.17256788921465 | 0.0336380623650936 | 0.173588270959853 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.10279914001876e-21 | 0.507365776643728 | 3.79043872244956e-15 | 0.426706601636016 | 9.16201955229704e-11 | 0.357274058250269 |
| AC | 7.54548322952853e-56 | 0.795371293485824 | 7.24844322987504e-39 | 0.704906662394938 | 3.10579565366619e-12 | 0.422314527609891 |
| PCC | 5.97432335911183e-34 | 0.736732072785844 | 6.9954119074526e-27 | 0.676253845348618 | 0.000202302241231851 | 0.26578154557275 |
| CER | 9.95947343911097e-43 | 0.848414147645922 | 1.12144550000937e-14 | 0.576790988863774 | 0.0255422819872133 | 0.18232605645942 |
| TCX | 1.6805003507542e-39 | 0.83083992553208 | 2.05346181731149e-08 | 0.438148433759281 | 1.11733486931102e-07 | 0.416873700717375 |
| FP | 2.127789032803e-22 | 0.645943490401417 | 1.43884747637951e-18 | 0.596971423997615 | 0.00879978074207142 | 0.195832230285613 |
| IFG | 0.000465605000958182 | 0.647615679838284 | 0.0174196110197064 | 0.471221386336034 | 0.162580022525922 | 0.288075601529992 |
| PG | 1.45361202910796e-43 | 0.804882796371477 | 9.27223504298561e-26 | 0.671692627117123 | 0.870956019778808 | 0.0119914004827531 |
| STG | 9.73473857404081e-22 | 0.82186519116939 | 3.26559607127943e-13 | 0.691564741252087 | 0.162331655325728 | 0.153850846379192 |
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Relation with AD stages for ERCC4 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 2.78369722401366e-05 | 0.395017881453896 |
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RelatedDrugs for ERCC4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ERCC4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| ERCC4 | C0268140 | Xeroderma pigmentosum, group F | 4 | CTD_human;UNIPROT |
| ERCC4 | C3806565 | XERODERMA PIGMENTOSUM, TYPE F/COCKAYNE SYNDROME | 4 | UNIPROT |
| ERCC4 | C0010828 | Cytopenia | 3 | GENOMICS_ENGLAND |
| ERCC4 | C0158995 | Congenital anemia | 3 | GENOMICS_ENGLAND |
| ERCC4 | C4025414 | Radial club hand | 3 | GENOMICS_ENGLAND |
| ERCC4 | C0431350 | Primary microcephaly | 2 | GENOMICS_ENGLAND |
| ERCC4 | C3808988 | FANCONI ANEMIA, COMPLEMENTATION GROUP Q | 2 | CTD_human;UNIPROT |
| ERCC4 | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human |
| ERCC4 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| ERCC4 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| ERCC4 | C0027654 | Embryonal Neoplasm | 1 | CTD_human |
| ERCC4 | C0027658 | Neoplasms, Germ Cell and Embryonal | 1 | CTD_human |
| ERCC4 | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| ERCC4 | C0039590 | Testicular Neoplasms | 1 | CTD_human |
| ERCC4 | C0153594 | Malignant neoplasm of testis | 1 | CTD_human |
| ERCC4 | C0205851 | Germ cell tumor | 1 | CTD_human |
| ERCC4 | C0205852 | Neoplasms, Embryonal and Mixed | 1 | CTD_human |
| ERCC4 | C0274861 | Arsenic Poisoning, Inorganic | 1 | CTD_human |
| ERCC4 | C0274862 | Nervous System, Organic Arsenic Poisoning | 1 | CTD_human |
| ERCC4 | C0311375 | Arsenic Poisoning | 1 | CTD_human |
| ERCC4 | C0376545 | Hematologic Neoplasms | 1 | GENOMICS_ENGLAND |
| ERCC4 | C0740345 | Germ Cell Cancer | 1 | CTD_human |
| ERCC4 | C0751364 | Cancer, Embryonal | 1 | CTD_human |
| ERCC4 | C0751365 | Cancer, Embryonal and Mixed | 1 | CTD_human |
| ERCC4 | C0751851 | Arsenic Encephalopathy | 1 | CTD_human |
| ERCC4 | C0751852 | Arsenic Induced Polyneuropathy | 1 | CTD_human |
| ERCC4 | C1720811 | Tumor of Rete Testis | 1 | CTD_human |
| ERCC4 | C1970416 | XFE Progeroid Syndrome | 1 | CTD_human;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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