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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for AMER3 |
 Gene summary |
| Gene information | Gene symbol | AMER3 | Gene ID | 205147 |
| Gene name | APC membrane recruitment protein 3 | |
| Synonyms | FAM123C | |
| Cytomap | 2q21.1 | |
| Type of gene | protein-coding | |
| Description | APC membrane recruitment protein 3family with sequence similarity 123Cprotein FAM123C | |
| Modification date | 20200313 | |
| UniProtAcc | Q8N944, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for AMER3 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_811057(130758243, +), ADediting_811058(130766182, +), ADediting_811059(130766514, +), ADediting_811060(130766560, +), ADediting_811061(130766571, +), ADediting_811062(130766583, +), ADediting_811063(130766596, +), ADediting_811064(130766597, +), ADediting_811065(130766600, +), ADediting_811066(130766609, +), ADediting_811067(130766623, +), ADediting_811068(130766626, +), ADediting_811069(130766636, +), ADediting_811070(130766638, +), ADediting_811071(130766681, +), ADediting_811072(130766755, +), |
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RNA editing positional annotations for AMER3 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_811057 | chr2_130758243_+ | intronic |
| ADediting_811058 | chr2_130766182_+ | UTR3 |
| ADediting_811059 | chr2_130766514_+ | UTR3 |
| ADediting_811060 | chr2_130766560_+ | UTR3 |
| ADediting_811061 | chr2_130766571_+ | UTR3 |
| ADediting_811062 | chr2_130766583_+ | UTR3 |
| ADediting_811063 | chr2_130766596_+ | UTR3 |
| ADediting_811064 | chr2_130766597_+ | UTR3 |
| ADediting_811065 | chr2_130766600_+ | UTR3 |
| ADediting_811066 | chr2_130766609_+ | UTR3 |
| ADediting_811067 | chr2_130766623_+ | UTR3 |
| ADediting_811068 | chr2_130766626_+ | UTR3 |
| ADediting_811069 | chr2_130766636_+ | UTR3 |
| ADediting_811070 | chr2_130766638_+ | UTR3 |
| ADediting_811071 | chr2_130766681_+ | UTR3 |
| ADediting_811072 | chr2_130766755_+ | UTR3 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_811057 | chr2_130758243_+ | SINE | Alu | Name=AluSx3 |
| ADediting_811058 | chr2_130766182_+ | DNA | MULE-MuDR | Name=Ricksha_b |
| ADediting_811059 | chr2_130766514_+ | SINE | Alu | Name=AluJb |
| ADediting_811060 | chr2_130766560_+ | SINE | Alu | Name=AluJb |
| ADediting_811061 | chr2_130766571_+ | SINE | Alu | Name=AluJb |
| ADediting_811062 | chr2_130766583_+ | SINE | Alu | Name=AluJb |
| ADediting_811063 | chr2_130766596_+ | SINE | Alu | Name=AluJb |
| ADediting_811064 | chr2_130766597_+ | SINE | Alu | Name=AluJb |
| ADediting_811065 | chr2_130766600_+ | SINE | Alu | Name=AluJb |
| ADediting_811066 | chr2_130766609_+ | SINE | Alu | Name=AluJb |
| ADediting_811067 | chr2_130766623_+ | SINE | Alu | Name=AluJb |
| ADediting_811068 | chr2_130766626_+ | SINE | Alu | Name=AluJb |
| ADediting_811069 | chr2_130766636_+ | SINE | Alu | Name=AluJb |
| ADediting_811070 | chr2_130766638_+ | SINE | Alu | Name=AluJb |
| ADediting_811071 | chr2_130766681_+ | SINE | Alu | Name=AluJb |
| ADediting_811072 | chr2_130766755_+ | SINE | Alu | Name=AluJb |
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RNA A-to-I editing events in the alternative splicing sites for AMER3 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for AMER3 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for AMER3 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for AMER3 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_811059 | chr2_130766514_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-340-3p | chr2 | 130766508 | 130766514 | 7mer-m8 | 130766494 | 130766515 | 146 | -17.88 |
| ADediting_811059 | chr2_130766514_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-6827-3p | chr2 | 130766508 | 130766514 | 7mer-m8 | 130766495 | 130766515 | 140 | -14.58 |
| ADediting_811060 | chr2_130766560_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-548ao-3p | chr2 | 130766558 | 130766564 | 7mer-m8 | 130766545 | 130766565 | 162 | -22.88 |
| ADediting_811062 | chr2_130766583_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-1827 | chr2 | 130766580 | 130766586 | 7mer-m8 | 130766571 | 130766587 | 149 | -17.58 |
| ADediting_811062 | chr2_130766583_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-1910-3p | chr2 | 130766579 | 130766585 | 7mer-m8 | 130766566 | 130766586 | 157 | -21.06 |
| ADediting_811062 | chr2_130766583_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-2467-3p | chr2 | 130766577 | 130766583 | 7mer-m8 | 130766562 | 130766584 | 159 | -22.61 |
| ADediting_811062 | chr2_130766583_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-3612 | chr2 | 130766581 | 130766587 | 7mer-m8 | 130766567 | 130766588 | 140 | -17.84 |
| ADediting_811062 | chr2_130766583_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-650 | chr2 | 130766581 | 130766587 | 7mer-m8 | 130766568 | 130766588 | 154 | -24.9 |
| ADediting_811062 | chr2_130766583_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-6511a-5p | chr2 | 130766579 | 130766585 | 7mer-m8 | 130766564 | 130766586 | 155 | -22.58 |
| ADediting_811064 | chr2_130766597_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-1199-5p | chr2 | 130766590 | 130766596 | 7mer-m8 | 130766578 | 130766597 | 156 | -28.57 |
| ADediting_811064 | chr2_130766597_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-6751-3p | chr2 | 130766590 | 130766596 | 7mer-m8 | 130766577 | 130766597 | 141 | -13.15 |
| ADediting_811066 | chr2_130766609_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-6765-5p | chr2 | 130766607 | 130766613 | 7mer-m8 | 130766593 | 130766614 | 155 | -27.93 |
| ADediting_811068 | chr2_130766626_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-3614-5p | chr2 | 130766619 | 130766625 | 7mer-m8 | 130766602 | 130766626 | 146 | -24.19 |
| ADediting_811068 | chr2_130766626_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-4691-3p | chr2 | 130766623 | 130766629 | 7mer-m8 | 130766604 | 130766630 | 156 | -30.33 |
| ADediting_811069 | chr2_130766636_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-17-3p | chr2 | 130766632 | 130766638 | 7mer-m8 | 130766617 | 130766639 | 158 | -20.42 |
| ADediting_811072 | chr2_130766755_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-6089 | chr2 | 130766753 | 130766759 | 7mer-m8 | 130766734 | 130766760 | 153 | -33.55 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_811059 | chr2_130766514_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-10a-5p | chr2 | 130766511 | 130766517 | 7mer-m8 | 130766498 | 130766518 | 142 | -12.31 |
| ADediting_811059 | chr2_130766514_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-10b-5p | chr2 | 130766511 | 130766517 | 7mer-m8 | 130766493 | 130766518 | 144 | -11.87 |
| ADediting_811059 | chr2_130766514_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-339-5p | chr2 | 130766510 | 130766516 | 7mer-m8 | 130766496 | 130766517 | 151 | -17.11 |
| ADediting_811059 | chr2_130766514_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-4725-5p | chr2 | 130766512 | 130766518 | 7mer-m8 | 130766499 | 130766519 | 140 | -15.96 |
| ADediting_811059 | chr2_130766514_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-504-5p | chr2 | 130766512 | 130766518 | 7mer-m8 | 130766500 | 130766519 | 147 | -18.15 |
| ADediting_811059 | chr2_130766514_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-5699-3p | chr2 | 130766509 | 130766515 | 7mer-m8 | 130766495 | 130766516 | 141 | -16.39 |
| ADediting_811061 | chr2_130766571_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-6807-5p | chr2 | 130766564 | 130766570 | 7mer-m8 | 130766552 | 130766571 | 145 | -17.74 |
| ADediting_811062 | chr2_130766583_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-let-7f-5p | chr2 | 130766580 | 130766586 | 7mer-m8 | 130766567 | 130766587 | 155 | -17.51 |
| ADediting_811062 | chr2_130766583_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-let-7g-5p | chr2 | 130766580 | 130766586 | 7mer-m8 | 130766567 | 130766587 | 155 | -18.28 |
| ADediting_811062 | chr2_130766583_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-3927-3p | chr2 | 130766579 | 130766585 | 7mer-m8 | 130766564 | 130766586 | 143 | -13.01 |
| ADediting_811062 | chr2_130766583_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-4451 | chr2 | 130766578 | 130766584 | 7mer-m8 | 130766568 | 130766585 | 149 | -17.56 |
| ADediting_811062 | chr2_130766583_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-4458 | chr2 | 130766580 | 130766586 | 7mer-m8 | 130766569 | 130766587 | 153 | -17.15 |
| ADediting_811062 | chr2_130766583_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-4500 | chr2 | 130766580 | 130766586 | 7mer-m8 | 130766571 | 130766587 | 147 | -12.77 |
| ADediting_811065 | chr2_130766600_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-1288-3p | chr2 | 130766597 | 130766603 | 7mer-m8 | 130766583 | 130766604 | 148 | -23.48 |
| ADediting_811065 | chr2_130766600_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-3169 | chr2 | 130766598 | 130766604 | 7mer-m8 | 130766585 | 130766605 | 155 | -19.8 |
| ADediting_811066 | chr2_130766609_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-1233-5p | chr2 | 130766603 | 130766609 | 7mer-m8 | 130766589 | 130766610 | 149 | -20.01 |
| ADediting_811066 | chr2_130766609_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-1273h-5p | chr2 | 130766602 | 130766608 | 7mer-m8 | 130766589 | 130766609 | 142 | -18.47 |
| ADediting_811066 | chr2_130766609_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-30b-3p | chr2 | 130766602 | 130766608 | 7mer-m8 | 130766590 | 130766609 | 146 | -17.14 |
| ADediting_811066 | chr2_130766609_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-3689a-3p | chr2 | 130766602 | 130766608 | 7mer-m8 | 130766588 | 130766609 | 146 | -16.26 |
| ADediting_811066 | chr2_130766609_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-3689b-3p | chr2 | 130766602 | 130766608 | 7mer-m8 | 130766588 | 130766609 | 146 | -18.07 |
| ADediting_811066 | chr2_130766609_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-3689c | chr2 | 130766602 | 130766608 | 7mer-m8 | 130766588 | 130766609 | 146 | -18.07 |
| ADediting_811066 | chr2_130766609_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-6779-5p | chr2 | 130766602 | 130766608 | 7mer-m8 | 130766592 | 130766609 | 150 | -20.9 |
| ADediting_811066 | chr2_130766609_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-6780a-5p | chr2 | 130766602 | 130766608 | 7mer-m8 | 130766591 | 130766609 | 148 | -21.64 |
| ADediting_811066 | chr2_130766609_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-6780a-5p | chr2 | 130766602 | 130766608 | 7mer-m8 | 130766600 | 130766622 | 140 | -21.13 |
| ADediting_811067 | chr2_130766623_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-12126 | chr2 | 130766618 | 130766625 | 8mer-1a | 130766602 | 130766625 | 147 | -12.83 |
| ADediting_811067 | chr2_130766623_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-887-5p | chr2 | 130766616 | 130766622 | 7mer-m8 | 130766604 | 130766623 | 143 | -18.12 |
| ADediting_811068 | chr2_130766626_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-5690 | chr2 | 130766623 | 130766629 | 7mer-m8 | 130766610 | 130766630 | 145 | -16.74 |
| ADediting_811071 | chr2_130766681_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-1283 | chr2 | 130766675 | 130766682 | 8mer-1a | 130766660 | 130766682 | 153 | -13.61 |
| ADediting_811071 | chr2_130766681_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-4684-5p | chr2 | 130766678 | 130766684 | 7mer-m8 | 130766664 | 130766685 | 143 | -8.1 |
| ADediting_811071 | chr2_130766681_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-519a-2-5p | chr2 | 130766677 | 130766684 | 8mer-1a | 130766664 | 130766684 | 154 | -15.27 |
| ADediting_811071 | chr2_130766681_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-520b-5p | chr2 | 130766677 | 130766684 | 8mer-1a | 130766664 | 130766684 | 154 | -15.27 |
| ADediting_811072 | chr2_130766755_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-3929 | chr2 | 130766752 | 130766758 | 7mer-m8 | 130766737 | 130766759 | 151 | -19.24 |
| ADediting_811072 | chr2_130766755_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-4478 | chr2 | 130766752 | 130766758 | 7mer-m8 | 130766743 | 130766759 | 147 | -20.51 |
| ADediting_811072 | chr2_130766755_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-485-5p | chr2 | 130766753 | 130766759 | 7mer-m8 | 130766740 | 130766760 | 144 | -16.88 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-4477b | chr2 | 130766727 | 130766733 | 7mer-m8 | 130766714 | 130766734 | 163 | -13.39 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-4477b | chr2 | 130767888 | 130767894 | 7mer-m8 | 130767874 | 130767895 | 140 | -8.66 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-381-3p | chr2 | 130767746 | 130767752 | 7mer-m8 | 130767732 | 130767753 | 152 | -15.04 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-641 | chr2 | 130766714 | 130766721 | 8mer-1a | 130766697 | 130766721 | 149 | -12.47 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-641 | chr2 | 130766739 | 130766746 | 8mer-1a | 130766722 | 130766746 | 144 | -12.4 |
| ADediting_1596844 | chr1_162342605_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-556-3p | chr2 | 130765238 | 130765245 | 8mer-1a | 130765223 | 130765245 | 146 | -8.42 |
| ADediting_291761 | chr11_93733708_- | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-1304-3p | chr2 | 130765689 | 130765695 | 7mer-m8 | 130765677 | 130765696 | 147 | -17.81 |
| ADediting_496066 | chr15_66496985_- | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-4512 | chr2 | 130765840 | 130765846 | 7mer-m8 | 130765826 | 130765847 | 146 | -15.47 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-4775 | chr2 | 130765086 | 130765092 | 7mer-m8 | 130765071 | 130765093 | 152 | -7.54 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1556067 | chr19_40282625_- | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-641 | chr2 | 130766172 | 130766178 | 7mer-m8 | 130766157 | 130766179 | 151 | -16.4 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-641 | chr2 | 130766172 | 130766178 | 7mer-m8 | 130766157 | 130766179 | 151 | -16.4 |
| ADediting_496066 | chr15_66496985_- | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-4512 | chr2 | 130767876 | 130767882 | 7mer-m8 | 130767862 | 130767883 | 140 | -20.31 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000178171.10 | ENST00000423981.1 | AMER3-202 | hsa-miR-4775 | chr2 | 130765531 | 130765537 | 7mer-m8 | 130765516 | 130765538 | 155 | -5.28 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for AMER3 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000423981.1 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_811058 | ENST00000423981.1 | chr2_130766182_+ | 4220 | -2507.50 | -2500.90 | -2519.00 |
| ADediting_811059 | ENST00000423981.1 | chr2_130766514_+ | 4552 | -2501.80 | -2500.90 | -2519.00 |
| ADediting_811060 | ENST00000423981.1 | chr2_130766560_+ | 4598 | -2500.20 | -2500.90 | -2519.00 |
| ADediting_811061 | ENST00000423981.1 | chr2_130766571_+ | 4609 | -2500.50 | -2500.90 | -2519.00 |
| ADediting_811062 | ENST00000423981.1 | chr2_130766583_+ | 4621 | -2504.40 | -2500.90 | -2519.00 |
| ADediting_811063 | ENST00000423981.1 | chr2_130766596_+ | 4634 | -2500.60 | -2500.90 | -2519.00 |
| ADediting_811064 | ENST00000423981.1 | chr2_130766597_+ | 4635 | -2500.60 | -2500.90 | -2519.00 |
| ADediting_811065 | ENST00000423981.1 | chr2_130766600_+ | 4638 | -2501.20 | -2500.90 | -2519.00 |
| ADediting_811066 | ENST00000423981.1 | chr2_130766609_+ | 4647 | -2501.60 | -2500.90 | -2519.00 |
| ADediting_811067 | ENST00000423981.1 | chr2_130766623_+ | 4661 | -2503.00 | -2500.90 | -2519.00 |
| ADediting_811068 | ENST00000423981.1 | chr2_130766626_+ | 4664 | -2503.70 | -2500.90 | -2519.00 |
| ADediting_811069 | ENST00000423981.1 | chr2_130766636_+ | 4674 | -2501.40 | -2500.90 | -2519.00 |
| ADediting_811070 | ENST00000423981.1 | chr2_130766638_+ | 4676 | -2500.20 | -2500.90 | -2519.00 |
| ADediting_811071 | ENST00000423981.1 | chr2_130766681_+ | 4719 | -2500.60 | -2500.90 | -2519.00 |
| ADediting_811072 | ENST00000423981.1 | chr2_130766755_+ | 4793 | -2500.60 | -2500.90 | -2519.00 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for AMER3 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_811060 | chr2_130766560_+ | 0.00476180179186036 | 0.22931310559475 | 3.43401086781013e-05 | 0.331404707943413 | 0.00481556355753679 | 0.229028335260142 |
| CER | ADediting_811062 | chr2_130766583_+ | 0.0473489188900344 | 0.162207741773125 | 7.5843633750483e-05 | 0.317363133408557 | 0.0166117746124742 | 0.195312973350346 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 9.04401798009875e-50 | 0.714837409585282 | 7.80820924635001e-62 | 0.769095912692829 | 0.365788955353814 | 0.0515399281395367 |
| AC | 3.34799545517545e-05 | 0.259170184272612 | 3.17563103789989e-11 | 0.403842097719533 | 0.000429844966728388 | -0.221037592873969 |
| PCC | 3.27643738457837e-17 | 0.560755920408401 | 2.51201880532516e-17 | 0.562450586872881 | 0.688521427620747 | 0.029190820395908 |
| CER | 1.256513240576e-13 | 0.557532618544116 | 4.98195007258241e-06 | 0.363015285593375 | 0.0689334549408793 | -0.148925482096131 |
| TCX | 4.37094334934231e-21 | 0.672488666543906 | 7.49979553751967e-59 | 0.911142208934711 | 5.72831941894537e-05 | -0.32241616329713 |
| FP | 7.4883501567883e-35 | 0.760616827565694 | 1.12713668356862e-49 | 0.844803855591965 | 0.0110313660754215 | 0.190107489104466 |
| IFG | 2.81191915155029e-07 | 0.830334563381858 | 1.09544165846724e-06 | 0.806997322222497 | 0.530784980689342 | 0.131549814216981 |
| PG | 3.90583098221132e-08 | 0.389515481489 | 6.47608389369924e-17 | 0.562560477809925 | 0.0213531531252881 | -0.168693332934445 |
| STG | 4.01556192895755e-27 | 0.871676532119825 | 4.54652311746132e-23 | 0.83588927596796 | 0.837901819871778 | 0.022657933536555 |
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Relation with AD stages for AMER3 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| PG | 4.484037239473e-06 | -0.329174711049228 |
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RelatedDrugs for AMER3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AMER3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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