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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for DPH1 |
 Gene summary |
| Gene information | Gene symbol | DPH1 | Gene ID | 1801 |
| Gene name | diphthamide biosynthesis 1 | |
| Synonyms | DEDSSH|DPH2L|DPH2L1|OVCA1 | |
| Cytomap | 17p13.3 | |
| Type of gene | protein-coding | |
| Description | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1DPH-like 1DPH1 homologDPH2-like 1S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1candidate tumor suppressor in ovarian cancer 1diphthamide biosynthesis protein 1diphtham | |
| Modification date | 20200313 | |
| UniProtAcc | Q9BZG8, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for DPH1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_594589(2032824, +), ADediting_594590(2032884, +), ADediting_594591(2033006, +), ADediting_594605(2037408, +), ADediting_594606(2037905, +), ADediting_594607(2038036, +), ADediting_594608(2038038, +), ADediting_594609(2038046, +), ADediting_594610(2038054, +), ADediting_594611(2038055, +), ADediting_594612(2038060, +), ADediting_594613(2038061, +), ADediting_594614(2038063, +), ADediting_594615(2038076, +), ADediting_594616(2038081, +), ADediting_594617(2038103, +), ADediting_594618(2038111, +), ADediting_594619(2038114, +), ADediting_594620(2038123, +), ADediting_594621(2038128, +), ADediting_594622(2038129, +), ADediting_594623(2038133, +), ADediting_594624(2038150, +), ADediting_594625(2038166, +), ADediting_594626(2038179, +), ADediting_594627(2038187, +), ADediting_594628(2038189, +), ADediting_594629(2038196, +), ADediting_594630(2038204, +), ADediting_594631(2038210, +), ADediting_594632(2038218, +), ADediting_594633(2038221, +), ADediting_594634(2038227, +), ADediting_594635(2038232, +), ADediting_594636(2038234, +), ADediting_594637(2038245, +), ADediting_594638(2038253, +), ADediting_594639(2038266, +), ADediting_594640(2038290, +), ADediting_594641(2038301, +), ADediting_594642(2038303, +), ADediting_594643(2038306, +), ADediting_594644(2038307, +), ADediting_594645(2039081, +), ADediting_594646(2039083, +), ADediting_594647(2039085, +), ADediting_594648(2039136, +), ADediting_594649(2039141, +), ADediting_594650(2039162, +), ADediting_594651(2039166, +), ADediting_594652(2039179, +), ADediting_594653(2039188, +), ADediting_594654(2039201, +), ADediting_594655(2039203, +), ADediting_594656(2039217, +), ADediting_594657(2039227, +), ADediting_594658(2039228, +), ADediting_594659(2039243, +), ADediting_594660(2039268, +), ADediting_594661(2039272, +), ADediting_594662(2039321, +), ADediting_594663(2039322, +), ADediting_594664(2039323, +), ADediting_594665(2039335, +), ADediting_594666(2039341, +), ADediting_594667(2039397, +), ADediting_594668(2039399, +), ADediting_594669(2039409, +), ADediting_594670(2039452, +), ADediting_594671(2039495, +), ADediting_594672(2039504, +), ADediting_594673(2039517, +), ADediting_594674(2039559, +), ADediting_594675(2039562, +), ADediting_594676(2039576, +), ADediting_594677(2039584, +), ADediting_594678(2039638, +), ADediting_594679(2039639, +), ADediting_594680(2039651, +), ADediting_594681(2039653, +), ADediting_594684(2039660, +), ADediting_1545604(2039161, +), ADediting_1545605(2039169, +), |
Top |
RNA editing positional annotations for DPH1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_594589 | chr17_2032824_+ | intronic |
| ADediting_594590 | chr17_2032884_+ | intronic |
| ADediting_594591 | chr17_2033006_+ | intronic |
| ADediting_594605 | chr17_2037408_+ | intronic |
| ADediting_594606 | chr17_2037905_+ | intronic |
| ADediting_594607 | chr17_2038036_+ | intronic |
| ADediting_594608 | chr17_2038038_+ | intronic |
| ADediting_594609 | chr17_2038046_+ | intronic |
| ADediting_594610 | chr17_2038054_+ | intronic |
| ADediting_594611 | chr17_2038055_+ | intronic |
| ADediting_594612 | chr17_2038060_+ | intronic |
| ADediting_594613 | chr17_2038061_+ | intronic |
| ADediting_594614 | chr17_2038063_+ | intronic |
| ADediting_594615 | chr17_2038076_+ | intronic |
| ADediting_594616 | chr17_2038081_+ | intronic |
| ADediting_594617 | chr17_2038103_+ | intronic |
| ADediting_594618 | chr17_2038111_+ | intronic |
| ADediting_594619 | chr17_2038114_+ | intronic |
| ADediting_594620 | chr17_2038123_+ | intronic |
| ADediting_594621 | chr17_2038128_+ | intronic |
| ADediting_594622 | chr17_2038129_+ | intronic |
| ADediting_594623 | chr17_2038133_+ | intronic |
| ADediting_594624 | chr17_2038150_+ | intronic |
| ADediting_594625 | chr17_2038166_+ | intronic |
| ADediting_594626 | chr17_2038179_+ | intronic |
| ADediting_594627 | chr17_2038187_+ | intronic |
| ADediting_594628 | chr17_2038189_+ | intronic |
| ADediting_594629 | chr17_2038196_+ | intronic |
| ADediting_594630 | chr17_2038204_+ | intronic |
| ADediting_594631 | chr17_2038210_+ | intronic |
| ADediting_594632 | chr17_2038218_+ | intronic |
| ADediting_594633 | chr17_2038221_+ | intronic |
| ADediting_594634 | chr17_2038227_+ | intronic |
| ADediting_594635 | chr17_2038232_+ | intronic |
| ADediting_594636 | chr17_2038234_+ | intronic |
| ADediting_594637 | chr17_2038245_+ | intronic |
| ADediting_594638 | chr17_2038253_+ | intronic |
| ADediting_594639 | chr17_2038266_+ | intronic |
| ADediting_594640 | chr17_2038290_+ | intronic |
| ADediting_594641 | chr17_2038301_+ | intronic |
| ADediting_594642 | chr17_2038303_+ | intronic |
| ADediting_594643 | chr17_2038306_+ | intronic |
| ADediting_594644 | chr17_2038307_+ | intronic |
| ADediting_594645 | chr17_2039081_+ | intronic |
| ADediting_594646 | chr17_2039083_+ | intronic |
| ADediting_594647 | chr17_2039085_+ | intronic |
| ADediting_594648 | chr17_2039136_+ | intronic |
| ADediting_594649 | chr17_2039141_+ | intronic |
| ADediting_594650 | chr17_2039162_+ | intronic |
| ADediting_594651 | chr17_2039166_+ | intronic |
| ADediting_594652 | chr17_2039179_+ | intronic |
| ADediting_594653 | chr17_2039188_+ | intronic |
| ADediting_594654 | chr17_2039201_+ | intronic |
| ADediting_594655 | chr17_2039203_+ | intronic |
| ADediting_594656 | chr17_2039217_+ | intronic |
| ADediting_594657 | chr17_2039227_+ | intronic |
| ADediting_594658 | chr17_2039228_+ | intronic |
| ADediting_594659 | chr17_2039243_+ | intronic |
| ADediting_594660 | chr17_2039268_+ | intronic |
| ADediting_594661 | chr17_2039272_+ | intronic |
| ADediting_594662 | chr17_2039321_+ | intronic |
| ADediting_594663 | chr17_2039322_+ | intronic |
| ADediting_594664 | chr17_2039323_+ | intronic |
| ADediting_594665 | chr17_2039335_+ | intronic |
| ADediting_594666 | chr17_2039341_+ | intronic |
| ADediting_594667 | chr17_2039397_+ | intronic |
| ADediting_594668 | chr17_2039399_+ | intronic |
| ADediting_594669 | chr17_2039409_+ | intronic |
| ADediting_594670 | chr17_2039452_+ | intronic |
| ADediting_594671 | chr17_2039495_+ | intronic |
| ADediting_594672 | chr17_2039504_+ | intronic |
| ADediting_594673 | chr17_2039517_+ | intronic |
| ADediting_594674 | chr17_2039559_+ | intronic |
| ADediting_594675 | chr17_2039562_+ | intronic |
| ADediting_594676 | chr17_2039576_+ | intronic |
| ADediting_594677 | chr17_2039584_+ | intronic |
| ADediting_594678 | chr17_2039638_+ | intronic |
| ADediting_594679 | chr17_2039639_+ | intronic |
| ADediting_594680 | chr17_2039651_+ | intronic |
| ADediting_594681 | chr17_2039653_+ | intronic |
| ADediting_594684 | chr17_2039660_+ | intronic |
| ADediting_1545604 | chr17_2039161_+ | intronic |
| ADediting_1545605 | chr17_2039169_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_594589 | chr17_2032824_+ | SINE | Alu | Name=AluY |
| ADediting_594590 | chr17_2032884_+ | SINE | Alu | Name=AluY |
| ADediting_594591 | chr17_2033006_+ | SINE | Alu | Name=AluY |
| ADediting_594606 | chr17_2037905_+ | SINE | MIR | Name=MIRb |
| ADediting_594607 | chr17_2038036_+ | SINE | Alu | Name=AluJb |
| ADediting_594608 | chr17_2038038_+ | SINE | Alu | Name=AluJb |
| ADediting_594609 | chr17_2038046_+ | SINE | Alu | Name=AluJb |
| ADediting_594610 | chr17_2038054_+ | SINE | Alu | Name=AluJb |
| ADediting_594611 | chr17_2038055_+ | SINE | Alu | Name=AluJb |
| ADediting_594612 | chr17_2038060_+ | SINE | Alu | Name=AluJb |
| ADediting_594613 | chr17_2038061_+ | SINE | Alu | Name=AluJb |
| ADediting_594614 | chr17_2038063_+ | SINE | Alu | Name=AluJb |
| ADediting_594615 | chr17_2038076_+ | SINE | Alu | Name=AluJb |
| ADediting_594616 | chr17_2038081_+ | SINE | Alu | Name=AluJb |
| ADediting_594617 | chr17_2038103_+ | SINE | Alu | Name=AluJb |
| ADediting_594618 | chr17_2038111_+ | SINE | Alu | Name=AluJb |
| ADediting_594619 | chr17_2038114_+ | SINE | Alu | Name=AluJb |
| ADediting_594620 | chr17_2038123_+ | SINE | Alu | Name=AluJb |
| ADediting_594621 | chr17_2038128_+ | SINE | Alu | Name=AluJb |
| ADediting_594622 | chr17_2038129_+ | SINE | Alu | Name=AluJb |
| ADediting_594623 | chr17_2038133_+ | SINE | Alu | Name=AluJb |
| ADediting_594624 | chr17_2038150_+ | SINE | Alu | Name=AluJb |
| ADediting_594625 | chr17_2038166_+ | SINE | Alu | Name=AluJb |
| ADediting_594626 | chr17_2038179_+ | SINE | Alu | Name=AluJb |
| ADediting_594627 | chr17_2038187_+ | SINE | Alu | Name=AluJb |
| ADediting_594628 | chr17_2038189_+ | SINE | Alu | Name=AluJb |
| ADediting_594629 | chr17_2038196_+ | SINE | Alu | Name=AluJb |
| ADediting_594630 | chr17_2038204_+ | SINE | Alu | Name=AluJb |
| ADediting_594631 | chr17_2038210_+ | SINE | Alu | Name=AluJb |
| ADediting_594632 | chr17_2038218_+ | SINE | Alu | Name=AluJb |
| ADediting_594633 | chr17_2038221_+ | SINE | Alu | Name=AluJb |
| ADediting_594634 | chr17_2038227_+ | SINE | Alu | Name=AluJb |
| ADediting_594635 | chr17_2038232_+ | SINE | Alu | Name=AluJb |
| ADediting_594636 | chr17_2038234_+ | SINE | Alu | Name=AluJb |
| ADediting_594637 | chr17_2038245_+ | SINE | Alu | Name=AluJb |
| ADediting_594638 | chr17_2038253_+ | SINE | Alu | Name=AluJb |
| ADediting_594639 | chr17_2038266_+ | SINE | Alu | Name=AluJb |
| ADediting_594640 | chr17_2038290_+ | SINE | Alu | Name=AluJb |
| ADediting_594641 | chr17_2038301_+ | SINE | Alu | Name=AluJb |
| ADediting_594642 | chr17_2038303_+ | SINE | Alu | Name=AluJb |
| ADediting_594643 | chr17_2038306_+ | SINE | Alu | Name=AluJb |
| ADediting_594644 | chr17_2038307_+ | SINE | Alu | Name=AluJb |
| ADediting_594645 | chr17_2039081_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594646 | chr17_2039083_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594647 | chr17_2039085_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594648 | chr17_2039136_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594649 | chr17_2039141_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594650 | chr17_2039162_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594651 | chr17_2039166_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594652 | chr17_2039179_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594653 | chr17_2039188_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594654 | chr17_2039201_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594655 | chr17_2039203_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594656 | chr17_2039217_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594657 | chr17_2039227_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594658 | chr17_2039228_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594659 | chr17_2039243_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594660 | chr17_2039268_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594661 | chr17_2039272_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594662 | chr17_2039321_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594663 | chr17_2039322_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594664 | chr17_2039323_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594665 | chr17_2039335_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594666 | chr17_2039341_+ | SINE | Alu | Name=AluSc8 |
| ADediting_594667 | chr17_2039397_+ | SINE | Alu | Name=AluY |
| ADediting_594668 | chr17_2039399_+ | SINE | Alu | Name=AluY |
| ADediting_594669 | chr17_2039409_+ | SINE | Alu | Name=AluY |
| ADediting_594670 | chr17_2039452_+ | SINE | Alu | Name=AluY |
| ADediting_594671 | chr17_2039495_+ | SINE | Alu | Name=AluY |
| ADediting_594672 | chr17_2039504_+ | SINE | Alu | Name=AluY |
| ADediting_594673 | chr17_2039517_+ | SINE | Alu | Name=AluY |
| ADediting_594674 | chr17_2039559_+ | SINE | Alu | Name=AluY |
| ADediting_594675 | chr17_2039562_+ | SINE | Alu | Name=AluY |
| ADediting_594676 | chr17_2039576_+ | SINE | Alu | Name=AluY |
| ADediting_594677 | chr17_2039584_+ | SINE | Alu | Name=AluY |
| ADediting_594678 | chr17_2039638_+ | SINE | Alu | Name=AluY |
| ADediting_594679 | chr17_2039639_+ | SINE | Alu | Name=AluY |
| ADediting_594680 | chr17_2039651_+ | SINE | Alu | Name=AluY |
| ADediting_594681 | chr17_2039653_+ | SINE | Alu | Name=AluY |
| ADediting_594684 | chr17_2039660_+ | SINE | Alu | Name=AluY |
| ADediting_1545604 | chr17_2039161_+ | SINE | Alu | Name=AluSc8 |
| ADediting_1545605 | chr17_2039169_+ | SINE | Alu | Name=AluSc8 |
Top |
RNA A-to-I editing events in the alternative splicing sites for DPH1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| ES | ADediting_594669 | chr17_2039409_+ | 2039403:2039425 | 3ss | 14i | AGTCTCACTCTGTCACCCAGGCT | 3.67 | AGTCTCGCTCTGTCACCCAGGCT | 4.42 |
| ES | ADediting_594674 | chr17_2039559_+ | 2039541:2039563 | 3ss | 2i | CTAAGTTTTTGTATTTTTAGTAG | 3.41 | CTAAGTTTTTGTATTTTTGGTAG | -4.54 |
| ES | ADediting_594674 | chr17_2039559_+ | 2039541:2039563 | 3ss | 2i | CTAAGTTTTTGTATTTTTAGTAG | 3.41 | CTAAGTTTTTGTATTTTTGGTAG | -4.54 |
| ES | ADediting_594679 | chr17_2039639_+ | 2039635:2039657 | 3ss | 16i | CCAAAGTGCTGGGATTACAGGCG | -1.62 | CCAAGGTGCTGGGATTACAGGCG | -1.12 |
| ES | ADediting_594679 | chr17_2039639_+ | 2039635:2039657 | 3ss | 16i | CCAAAGTGCTGGGATTACAGGCG | -1.62 | CCAAGGTGCTGGGATTACAGGCG | -1.12 |
| ES | ADediting_594680 | chr17_2039651_+ | 2039635:2039657 | 3ss | 4i | CCAAAGTGCTGGGATTACAGGCG | -1.62 | CCAAAGTGCTGGGATTGCAGGCG | -0.61 |
| ES | ADediting_594680 | chr17_2039651_+ | 2039635:2039657 | 3ss | 4i | CCAAAGTGCTGGGATTACAGGCG | -1.62 | CCAAAGTGCTGGGATTGCAGGCG | -0.61 |
| ME1 | ADediting_594674 | chr17_2039559_+ | 2039541:2039563 | 3ss | 2i | CTAAGTTTTTGTATTTTTAGTAG | 3.41 | CTAAGTTTTTGTATTTTTGGTAG | -4.54 |
| ME1 | ADediting_594674 | chr17_2039559_+ | 2039541:2039563 | 3ss | 2i | CTAAGTTTTTGTATTTTTAGTAG | 3.41 | CTAAGTTTTTGTATTTTTGGTAG | -4.54 |
| ME1 | ADediting_594679 | chr17_2039639_+ | 2039635:2039657 | 3ss | 16i | CCAAAGTGCTGGGATTACAGGCG | -1.62 | CCAAGGTGCTGGGATTACAGGCG | -1.12 |
| ME1 | ADediting_594679 | chr17_2039639_+ | 2039635:2039657 | 3ss | 16i | CCAAAGTGCTGGGATTACAGGCG | -1.62 | CCAAGGTGCTGGGATTACAGGCG | -1.12 |
| ME1 | ADediting_594680 | chr17_2039651_+ | 2039635:2039657 | 3ss | 4i | CCAAAGTGCTGGGATTACAGGCG | -1.62 | CCAAAGTGCTGGGATTGCAGGCG | -0.61 |
| ME1 | ADediting_594680 | chr17_2039651_+ | 2039635:2039657 | 3ss | 4i | CCAAAGTGCTGGGATTACAGGCG | -1.62 | CCAAAGTGCTGGGATTGCAGGCG | -0.61 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for DPH1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for DPH1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for DPH1 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1391023 | chr8_140732605_- | ENSG00000108963.17 | ENST00000571710.5 | DPH1-207 | hsa-miR-151a-3p | chr17 | 2042340 | 2042346 | 7mer-m8 | 2042327 | 2042347 | 140 | -14.73 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000108963.17 | ENST00000263083.10 | DPH1-201 | hsa-miR-641 | chr17 | 2043115 | 2043121 | 7mer-m8 | 2043099 | 2043122 | 140 | -18 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000108963.17 | ENST00000571710.5 | DPH1-207 | hsa-miR-641 | chr17 | 2043115 | 2043121 | 7mer-m8 | 2043099 | 2043122 | 140 | -18 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000108963.17 | ENST00000607788.1 | DPH1-217 | hsa-miR-641 | chr17 | 2043115 | 2043121 | 7mer-m8 | 2043099 | 2043122 | 140 | -18 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_496066 | chr15_66496985_- | ENSG00000108963.17 | ENST00000263083.10 | DPH1-201 | hsa-miR-4512 | chr17 | 2042912 | 2042918 | 7mer-m8 | 2042897 | 2042919 | 141 | -13.81 |
| ADediting_496066 | chr15_66496985_- | ENSG00000108963.17 | ENST00000570477.5 | DPH1-203 | hsa-miR-4512 | chr17 | 2042912 | 2042918 | 7mer-m8 | 2042897 | 2042919 | 141 | -13.81 |
| ADediting_496066 | chr15_66496985_- | ENSG00000108963.17 | ENST00000571418.5 | DPH1-206 | hsa-miR-4512 | chr17 | 2042912 | 2042918 | 7mer-m8 | 2042897 | 2042919 | 141 | -13.81 |
| ADediting_496066 | chr15_66496985_- | ENSG00000108963.17 | ENST00000571710.5 | DPH1-207 | hsa-miR-4512 | chr17 | 2042912 | 2042918 | 7mer-m8 | 2042897 | 2042919 | 141 | -13.81 |
| ADediting_496066 | chr15_66496985_- | ENSG00000108963.17 | ENST00000575162.1 | DPH1-212 | hsa-miR-4512 | chr17 | 2042912 | 2042918 | 7mer-m8 | 2042897 | 2042918 | 141 | -13.58 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000108963.17 | ENST00000263083.10 | DPH1-201 | hsa-miR-1273h-3p | chr17 | 2042690 | 2042696 | 7mer-m8 | 2042673 | 2042697 | 150 | -24.17 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000108963.17 | ENST00000570477.5 | DPH1-203 | hsa-miR-1273h-3p | chr17 | 2042690 | 2042696 | 7mer-m8 | 2042673 | 2042697 | 150 | -24.17 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000108963.17 | ENST00000571418.5 | DPH1-206 | hsa-miR-1273h-3p | chr17 | 2042690 | 2042696 | 7mer-m8 | 2042673 | 2042697 | 150 | -24.17 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000108963.17 | ENST00000571710.5 | DPH1-207 | hsa-miR-1273h-3p | chr17 | 2042690 | 2042696 | 7mer-m8 | 2042673 | 2042697 | 150 | -24.17 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000108963.17 | ENST00000575162.1 | DPH1-212 | hsa-miR-1273h-3p | chr17 | 2042690 | 2042696 | 7mer-m8 | 2042673 | 2042697 | 150 | -24.17 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for DPH1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for DPH1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_594605 | chr17_2037408_+ | 1.0041127885348e-13 | 0.405894386206213 | 1.02822903782888e-20 | 0.49666687781551 | 0.0452458302947216 | 0.113816491218305 |
| TCX | ADediting_594605 | chr17_2037408_+ | 2.95775408307678e-06 | 0.371003124489534 | 0.000590861242896481 | 0.277326590926502 | 0.864792674106262 | 0.0140196173435167 |
| DLPFC | ADediting_594606 | chr17_2037905_+ | 1.20386031735885e-07 | 0.295088624616745 | 3.84718757661165e-12 | 0.380893529430664 | 0.19700619083247 | 0.0734720915856094 |
| DLPFC | ADediting_594607 | chr17_2038036_+ | 0.000217838719870745 | 0.20852619292368 | 1.5919245482739e-10 | 0.35295270154679 | 0.0579494438341234 | 0.107811568292985 |
| TCX | ADediting_594607 | chr17_2038036_+ | 2.69391465768305e-05 | 0.335572432567967 | 2.55844173508909e-05 | 0.33645066921268 | 0.598400276710838 | -0.0433474689940976 |
| CER | ADediting_594608 | chr17_2038038_+ | 0.00146894537085465 | 0.25746820027294 | 4.31579411184081e-05 | 0.327424648234088 | 0.056342115771518 | 0.15616757124698 |
| TCX | ADediting_594608 | chr17_2038038_+ | 4.94076681482896e-08 | 0.427304795164695 | 6.64074284111114e-06 | 0.358518924645559 | 0.395809287919028 | 0.0698306053487876 |
| DLPFC | ADediting_594610 | chr17_2038054_+ | 0.00844029442117623 | 0.14936049310104 | 1.07334833323053e-08 | 0.31763441611253 | 0.102588186836877 | 0.0928906873048506 |
| CER | ADediting_594610 | chr17_2038054_+ | 1.92488990178738e-07 | 0.4097192170693 | 4.03591943232853e-11 | 0.505837830671247 | 0.0312793180686769 | 0.175930536493366 |
| TCX | ADediting_594610 | chr17_2038054_+ | 1.10599274537815e-06 | 0.385518075051447 | 1.62302264181972e-06 | 0.379941406398199 | 0.817832542273357 | 0.0189636089757982 |
| CER | ADediting_594611 | chr17_2038055_+ | 3.72221208162002e-05 | 0.330007584055777 | 0.000307783189531337 | 0.290688830103285 | 0.573011210457294 | 0.046382802222561 |
| TCX | ADediting_594611 | chr17_2038055_+ | 2.32208799880973e-06 | 0.37463887482236 | 3.13105845021796e-05 | 0.33299757859461 | 0.972505437017184 | 0.00283788377048579 |
| CER | ADediting_594613 | chr17_2038061_+ | 5.47212382721567e-05 | 0.323231496347077 | 6.86640803372639e-07 | 0.392308900919339 | 0.46069929140504 | 0.0606847276598209 |
| TCX | ADediting_594613 | chr17_2038061_+ | 3.8636720773824e-07 | 0.400303894787959 | 1.0843118617041e-07 | 0.417263514889727 | 0.892189007574907 | 0.0111593837147627 |
| DLPFC | ADediting_594615 | chr17_2038076_+ | 9.91426291011041e-07 | 0.273703306769704 | 5.73214529278974e-14 | 0.409558821664377 | 0.173270350318493 | 0.0775401137958618 |
| CER | ADediting_594615 | chr17_2038076_+ | 1.38674623428164e-08 | 0.442876672879091 | 1.24383874444733e-12 | 0.538039694308322 | 0.107697770362523 | 0.13187280509588 |
| TCX | ADediting_594615 | chr17_2038076_+ | 5.34583193224949e-05 | 0.323646677154587 | 3.54478084422488e-10 | 0.483875192767812 | 0.282911486998972 | -0.0882425868248082 |
| DLPFC | ADediting_594616 | chr17_2038081_+ | 1.46661189598883e-06 | 0.269525782990983 | 2.20900871040443e-13 | 0.400663376123997 | 0.0382776585861539 | 0.117740300004241 |
| CER | ADediting_594616 | chr17_2038081_+ | 7.42768374944261e-08 | 0.422137316279417 | 2.67021191863286e-08 | 0.434944445555373 | 0.61954370642531 | 0.0408637258027266 |
| TCX | ADediting_594616 | chr17_2038081_+ | 5.16319906860255e-07 | 0.396298860910886 | 3.12990126638029e-07 | 0.403180652994931 | 0.652707989645587 | -0.0370398662081805 |
| DLPFC | ADediting_594618 | chr17_2038111_+ | 2.98826430657844e-12 | 0.382695955681325 | 1.10950143147401e-15 | 0.434153805840141 | 0.059650891371732 | 0.107092769584606 |
| TCX | ADediting_594618 | chr17_2038111_+ | 3.79061775390367e-06 | 0.367228812875675 | 0.000406063430196646 | 0.285091722730794 | 0.716099497376115 | 0.0299378585332796 |
| DLPFC | ADediting_594622 | chr17_2038129_+ | 0.00129659628179012 | 0.181906332355611 | 2.04421910221682e-09 | 0.332082396564131 | 0.0047422201525939 | 0.160006520405704 |
| TCX | ADediting_594622 | chr17_2038129_+ | 1.20520633515938e-06 | 0.38427791061085 | 5.23441293752899e-05 | 0.324020673307641 | 0.0754204544972253 | 0.145608238721154 |
| CER | ADediting_594630 | chr17_2038204_+ | 2.65962037802334e-07 | 0.405386155284326 | 7.48120648152283e-08 | 0.422045530757768 | 0.0491440766381011 | 0.160930268463401 |
| CER | ADediting_594632 | chr17_2038218_+ | 0.000496465858762562 | 0.280958207888311 | 2.59962675384758e-05 | 0.336179135312232 | 0.120521417812487 | 0.127316951826979 |
| CER | ADediting_594636 | chr17_2038234_+ | 0.00385072670368325 | 0.234638082732719 | 9.92717984584711e-05 | 0.312430660361924 | 0.0724349560851811 | 0.147104964625185 |
| CER | ADediting_594637 | chr17_2038245_+ | 1.59410585319288e-06 | 0.380205102854162 | 1.78420551708005e-06 | 0.378548747045568 | 0.104368141853204 | 0.133124733912687 |
| DLPFC | ADediting_594645 | chr17_2039081_+ | 4.01888610186414e-05 | 0.23099854423888 | 2.40650208520515e-12 | 0.384231866429955 | 0.0299406117397044 | 0.123324594382782 |
| CER | ADediting_594645 | chr17_2039081_+ | 1.49056032992029e-09 | 0.468453787440317 | 6.24580464657376e-08 | 0.424344505653781 | 0.452157160762819 | 0.0618447042059358 |
| TCX | ADediting_594645 | chr17_2039081_+ | 7.74436159854682e-05 | 0.316983665975912 | 0.00310334764026068 | 0.239933254811084 | 0.317637845250344 | 0.0821436305718101 |
| DLPFC | ADediting_594646 | chr17_2039083_+ | 0.000142041268022877 | 0.214433412209489 | 5.46945691635766e-12 | 0.378364890958504 | 0.0076656749342287 | 0.151183546775882 |
| CER | ADediting_594646 | chr17_2039083_+ | 0.000160716588209352 | 0.303380735815429 | 4.16320967740736e-05 | 0.328055138762477 | 0.412606552718912 | 0.0673844348083731 |
| DLPFC | ADediting_594647 | chr17_2039085_+ | 0.00026956312078097 | 0.205521189701784 | 5.27125636283346e-10 | 0.343355714395134 | 0.0300831167234666 | 0.123218561895398 |
| CER | ADediting_594648 | chr17_2039136_+ | 0.000124138173533088 | 0.308268076035474 | 1.68082881140098e-05 | 0.34350435431674 | 0.0678738897955966 | 0.149491177668415 |
| DLPFC | ADediting_594649 | chr17_2039141_+ | 1.47084694481625e-05 | 0.24337145530428 | 1.60537628674552e-11 | 0.37048739855287 | 0.655925912307489 | 0.0254037990175715 |
| DLPFC | ADediting_594654 | chr17_2039201_+ | 3.16497885640536e-05 | 0.233999507060628 | 1.87963697696558e-10 | 0.351640296400538 | 0.0396788432607967 | 0.116905477747573 |
| TCX | ADediting_594654 | chr17_2039201_+ | 0.000895414571284353 | 0.268447808746923 | 0.000179840771238645 | 0.301225915907192 | 0.660509096629542 | 0.0361520798925367 |
| DLPFC | ADediting_594656 | chr17_2039217_+ | 1.032609893372e-07 | 0.296578071581522 | 1.08787072877362e-11 | 0.373358902032681 | 0.879031063092325 | 0.00867914335687882 |
| DLPFC | ADediting_594659 | chr17_2039243_+ | 1.16160260802767e-08 | 0.316926594300453 | 3.21518166873952e-11 | 0.365290695310025 | 0.0687383408377949 | 0.103517059360212 |
| DLPFC | ADediting_594660 | chr17_2039268_+ | 7.60434209742669e-06 | 0.251149779746759 | 6.09128768434403e-13 | 0.393795683069512 | 0.0296388214960547 | 0.123550577865014 |
| CER | ADediting_594660 | chr17_2039268_+ | 0.000616857808438554 | 0.276420612528382 | 0.000131460464655094 | 0.307190823538308 | 0.232009262039057 | 0.0981729279095279 |
| DLPFC | ADediting_594661 | chr17_2039272_+ | 0.000240008629386491 | 0.207164424669597 | 4.73089877659965e-08 | 0.304027138998012 | 0.757328570157987 | 0.0176193101085302 |
| CER | ADediting_594662 | chr17_2039321_+ | 6.36613629192445e-05 | 0.320526019306911 | 2.13767891440668e-06 | 0.375872191119589 | 0.020314760599496 | 0.189333486305751 |
| DLPFC | ADediting_594664 | chr17_2039323_+ | 0.00241825385675677 | 0.171697235007774 | 3.33340195154116e-08 | 0.307301692408671 | 0.0166726510698866 | 0.13587920310603 |
| CER | ADediting_594664 | chr17_2039323_+ | 0.000521723297598292 | 0.279927914867762 | 6.7824261823599e-05 | 0.319385884225339 | 0.413594789131788 | 0.0672423650941524 |
| TCX | ADediting_594664 | chr17_2039323_+ | 0.0105634276694852 | 0.208211989733261 | 0.132111178240081 | 0.12351235233639 | 0.000136907446147263 | 0.306425181219707 |
| DLPFC | ADediting_594665 | chr17_2039335_+ | 0.00569807215892604 | 0.156684586541132 | 1.37678854700672e-08 | 0.315397911291581 | 0.0906504452804819 | 0.0962634004214172 |
| CER | ADediting_594665 | chr17_2039335_+ | 1.63913724411979e-06 | 0.379796388044594 | 6.69437659885061e-12 | 0.522886024161754 | 0.0140056098469839 | 0.200261576466807 |
| DLPFC | ADediting_594666 | chr17_2039341_+ | 0.000140360683619721 | 0.214595533632862 | 1.87453860225407e-09 | 0.332816938557845 | 0.0675740880728739 | 0.103952659957943 |
| CER | ADediting_594666 | chr17_2039341_+ | 7.76641017680485e-08 | 0.421566807293326 | 1.09720195467126e-12 | 0.539139464111835 | 0.022478695056175 | 0.186263626241308 |
| TCX | ADediting_594666 | chr17_2039341_+ | 0.0991214913483368 | 0.135162769776346 | 1.11601386027541e-05 | 0.35022018330752 | 0.661839478899898 | 0.0360010966332074 |
| DLPFC | ADediting_594671 | chr17_2039495_+ | 0.0178145942705687 | 0.134506957751488 | 2.70868025895503e-08 | 0.309223887410208 | 0.114126902759265 | 0.0899143911891241 |
| DLPFC | ADediting_594677 | chr17_2039584_+ | 0.00267419013090846 | 0.169996998260517 | 1.4725360267557e-09 | 0.33485286791904 | 0.0716801897841579 | 0.102442656765141 |
| TCX | ADediting_594677 | chr17_2039584_+ | 0.00495583515372591 | 0.228298522053837 | 2.54036614116873e-05 | 0.336571143658661 | 0.277215322460087 | -0.0892898115712593 |
| DLPFC | ADediting_594679 | chr17_2039639_+ | 1.15521695986731e-05 | 0.246249241441907 | 3.51955702001914e-15 | 0.42716129088402 | 0.0682619141145036 | 0.10369457728286 |
| DLPFC | ADediting_594680 | chr17_2039651_+ | 0.0345862982830612 | 0.120070464951112 | 5.92949638437569e-09 | 0.32289228172173 | 0.0528390456446328 | 0.110080976432233 |
| CER | ADediting_594680 | chr17_2039651_+ | 0.000595007052878363 | 0.277179678599479 | 1.4254814467023e-08 | 0.442547197706721 | 0.406817334121113 | 0.0682207429576517 |
| TCX | ADediting_594680 | chr17_2039651_+ | 0.00336181018998674 | 0.237983310022046 | 3.06553734169713e-05 | 0.333361083804843 | 0.567533278672028 | 0.0470458425632576 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 7.26782874627429e-24 | 0.530137472823121 | 2.71744119163147e-20 | 0.491889541734717 | 6.40576546285144e-37 | 0.638617321426856 |
| AC | 2.72922232225238e-65 | 0.831617080836204 | 2.50631804594745e-53 | 0.784250510582022 | 5.24380796915818e-16 | 0.482846852665693 |
| PCC | 4.53605385154845e-40 | 0.778387163587947 | 8.28258366243499e-42 | 0.78878426924848 | 1.23043960836788e-06 | 0.342553503473948 |
| CER | 6.81867157353076e-21 | 0.670049071975725 | 3.53097357187636e-27 | 0.739101937373226 | 2.17627843682363e-06 | 0.375605887963435 |
| TCX | 1.08200191802404e-23 | 0.70328711912551 | 1.74291191343e-24 | 0.711934369017823 | 0.0265647619204726 | 0.181101937068282 |
| FP | 4.37314797623708e-28 | 0.705215527604314 | 2.63311823593727e-10 | 0.451089008167547 | 5.09735526442308e-08 | 0.394437009943399 |
| IFG | 4.92180617242206e-07 | 0.821125035773034 | 7.67178269810151e-09 | 0.878607154480174 | 0.0365948227742853 | 0.419997563624409 |
| STG | 3.27495100981243e-16 | 0.747216022163851 | 1.55957745513589e-06 | 0.496512675720737 | 0.00386567266352004 | 0.311974172688435 |
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Relation with AD stages for DPH1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_594610 | chr17_2038054_+ | 0.00140398327068024 | 0.303572418816324 |
| CER | ADediting_594615 | chr17_2038076_+ | 0.000255546462794434 | 0.345006950695579 |
| CER | ADediting_594666 | chr17_2039341_+ | 0.00106934863901264 | 0.310601306104748 |
| IFG | ADediting_594637 | chr17_2038245_+ | 0.0114832828948601 | 0.497024751194064 |
| IFG | ADediting_594639 | chr17_2038266_+ | 0.0354713369979928 | 0.422303326441651 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 3.41858763889779e-09 | 0.530869568744835 |
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RelatedDrugs for DPH1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DPH1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| DPH1 | C4310801 | DEVELOPMENTAL DELAY WITH SHORT STATURE, DYSMORPHIC FEATURES, AND SPARSE HAIR | 2 | CTD_human;ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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