ADeditome: functional annotation of RNA A-to-I editing in AD

Gene summary for DOCK1

Gene summary

Gene information	Gene symbol	DOCK1
	Gene ID	1793
	Gene name	dedicator of cytokinesis 1
	Synonyms	DOCK180\|ced5
	Cytomap	10q26.2
	Type of gene	protein-coding
	Description	dedicator of cytokinesis protein 1180 kDa protein downstream of CRKDOwnstream of CrK
	Modification date	20200327
	UniProtAcc	Q14185,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for DOCK1

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_175030(126912145, +), ADediting_175031(126912167, +), ADediting_175032(126912174, +), ADediting_175033(126912214, +), ADediting_175034(126912310, +), ADediting_175035(126912319, +), ADediting_175036(126912345, +), ADediting_175037(126912380, +), ADediting_175038(126914451, +), ADediting_175039(126914496, +), ADediting_175044(126915480, +), ADediting_175045(126915482, +), ADediting_175046(126915483, +), ADediting_175047(126915519, +), ADediting_175048(126915522, +), ADediting_175049(126915545, +), ADediting_175050(126915548, +), ADediting_175051(126915558, +), ADediting_175052(126915568, +), ADediting_175053(126915571, +), ADediting_175056(126915658, +), ADediting_175057(126915725, +), ADediting_175060(126921011, +), ADediting_175061(126921013, +), ADediting_175062(126921021, +), ADediting_175063(126921079, +), ADediting_175064(126921080, +), ADediting_175065(126921082, +), ADediting_175066(126921106, +), ADediting_175067(126921115, +), ADediting_175068(126921132, +), ADediting_175069(126921145, +), ADediting_175070(126921150, +), ADediting_175071(126921722, +), ADediting_175072(126921732, +), ADediting_175073(126921739, +), ADediting_175074(126921752, +), ADediting_175075(126921753, +), ADediting_175076(126921782, +), ADediting_175077(126921794, +), ADediting_175078(126921798, +), ADediting_175079(126921802, +), ADediting_175080(126921832, +), ADediting_175081(126921861, +), ADediting_175082(126922016, +), ADediting_175083(126922021, +), ADediting_175084(126922026, +), ADediting_175085(126922047, +), ADediting_175086(126922065, +), ADediting_175087(126922069, +), ADediting_175088(126922081, +), ADediting_175089(126922085, +), ADediting_175090(126922091, +), ADediting_175091(126922097, +), ADediting_175092(126922105, +), ADediting_175093(126922106, +), ADediting_175094(126922107, +), ADediting_175095(126922121, +), ADediting_175096(126922146, +), ADediting_175097(126923015, +), ADediting_175098(126923477, +), ADediting_175099(126923493, +), ADediting_175100(126925453, +), ADediting_175134(127036718, +), ADediting_175135(127036745, +), ADediting_175137(127051638, +), ADediting_175138(127051641, +), ADediting_175139(127051683, +), ADediting_175140(127051716, +), ADediting_175141(127051748, +), ADediting_175142(127051792, +), ADediting_175143(127052276, +), ADediting_175144(127052401, +), ADediting_175145(127052404, +), ADediting_175146(127052410, +), ADediting_175147(127069435, +), ADediting_175148(127074990, +), ADediting_175149(127074993, +), ADediting_175150(127075005, +), ADediting_175151(127075022, +), ADediting_175152(127075058, +), ADediting_175153(127075071, +), ADediting_175154(127075075, +), ADediting_175155(127075372, +), ADediting_175156(127075389, +), ADediting_175157(127075397, +), ADediting_175158(127075398, +), ADediting_175159(127075401, +), ADediting_175160(127075647, +), ADediting_175199(127224359, +), ADediting_175200(127224626, +), ADediting_175220(127250615, +), ADediting_175221(127250626, +), ADediting_175222(127250648, +), ADediting_175223(127250671, +), ADediting_175224(127250672, +), ADediting_175225(127250698, +), ADediting_175226(127250713, +), ADediting_175228(127251019, +), ADediting_175229(127251026, +), ADediting_175230(127251027, +), ADediting_175231(127251040, +), ADediting_175232(127251063, +), ADediting_175233(127251080, +), ADediting_175234(127251102, +), ADediting_175235(127251128, +), ADediting_175236(127251150, +), ADediting_175237(127251195, +), ADediting_175238(127251259, +), ADediting_175279(127266564, +), ADediting_175280(127266571, +), ADediting_175281(127266597, +), ADediting_175282(127266599, +), ADediting_175283(127266600, +), ADediting_175284(127266605, +), ADediting_175285(127266606, +), ADediting_175286(127266624, +), ADediting_175287(127266625, +), ADediting_175288(127267676, +), ADediting_175289(127267677, +), ADediting_175290(127267701, +), ADediting_175291(127267704, +), ADediting_175292(127268393, +), ADediting_175307(127388120, +), ADediting_175327(127411508, +), ADediting_175328(127411579, +), ADediting_175329(127411585, +), ADediting_175330(127411586, +), ADediting_175331(127411591, +), ADediting_175332(127411592, +), ADediting_175333(127411612, +), ADediting_175334(127411645, +), ADediting_175335(127411654, +), ADediting_175336(127411655, +), ADediting_175337(127411657, +), ADediting_175338(127411662, +), ADediting_175339(127411663, +), ADediting_175340(127411676, +), ADediting_175341(127411679, +), ADediting_175342(127411681, +), ADediting_175343(127411682, +), ADediting_175344(127411719, +), ADediting_175345(127411720, +), ADediting_175346(127411761, +), ADediting_175347(127411765, +), ADediting_175348(127411789, +), ADediting_175349(127411986, +), ADediting_175350(127412032, +), ADediting_175351(127412043, +), ADediting_175352(127412056, +), ADediting_175353(127412089, +), ADediting_175354(127412147, +), ADediting_175355(127412161, +), ADediting_175356(127412169, +), ADediting_175357(127412236, +), ADediting_175358(127413981, +), ADediting_175359(127414006, +), ADediting_175360(127414012, +), ADediting_175361(127414022, +), ADediting_175362(127414029, +), ADediting_175363(127414046, +), ADediting_175364(127414078, +), ADediting_175365(127414104, +), ADediting_175366(127414112, +), ADediting_175367(127414173, +), ADediting_175368(127414174, +), ADediting_1522833(127075305, +), ADediting_1522834(127412757, +), ADediting_1522835(127414011, +), ADediting_1522836(127414051, +), ADediting_1522837(127414069, +), ADediting_1522838(127414077, +), ADediting_1604396(126985906, +), ADediting_1604400(127321917, +), ADediting_1604401(127321927, +), ADediting_1604402(127321976, +), ADediting_1604403(127321983, +), ADediting_1604404(127321992, +), ADediting_1604405(127322038, +), ADediting_1604406(127322048, +), ADediting_1604407(127322238, +), ADediting_1604408(127322282, +), ADediting_1604409(127322290, +), ADediting_1604410(127322319, +), ADediting_1604411(127322329, +), ADediting_1604412(127322335, +), ADediting_1604413(127322370, +), ADediting_1604414(127322395, +), ADediting_1604415(127322399, +), ADediting_1604416(127322425, +), ADediting_1604417(127322442, +), ADediting_1604418(127322463, +), ADediting_1604419(127322465, +), ADediting_1604421(127414186, +),

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RNA editing positional annotations for DOCK1 using Annovar

Protein coding RNA editing(s).

ADeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_175030	chr10_126912145_+	intronic
ADediting_175031	chr10_126912167_+	intronic
ADediting_175032	chr10_126912174_+	intronic
ADediting_175033	chr10_126912214_+	intronic
ADediting_175034	chr10_126912310_+	intronic
ADediting_175035	chr10_126912319_+	intronic
ADediting_175036	chr10_126912345_+	intronic
ADediting_175037	chr10_126912380_+	intronic
ADediting_175038	chr10_126914451_+	intronic
ADediting_175039	chr10_126914496_+	intronic
ADediting_175044	chr10_126915480_+	intronic
ADediting_175045	chr10_126915482_+	intronic
ADediting_175046	chr10_126915483_+	intronic
ADediting_175047	chr10_126915519_+	intronic
ADediting_175048	chr10_126915522_+	intronic
ADediting_175049	chr10_126915545_+	intronic
ADediting_175050	chr10_126915548_+	intronic
ADediting_175051	chr10_126915558_+	intronic
ADediting_175052	chr10_126915568_+	intronic
ADediting_175053	chr10_126915571_+	intronic
ADediting_175056	chr10_126915658_+	intronic
ADediting_175057	chr10_126915725_+	intronic
ADediting_175060	chr10_126921011_+	intronic
ADediting_175061	chr10_126921013_+	intronic
ADediting_175062	chr10_126921021_+	intronic
ADediting_175063	chr10_126921079_+	intronic
ADediting_175064	chr10_126921080_+	intronic
ADediting_175065	chr10_126921082_+	intronic
ADediting_175066	chr10_126921106_+	intronic
ADediting_175067	chr10_126921115_+	intronic
ADediting_175068	chr10_126921132_+	intronic
ADediting_175069	chr10_126921145_+	intronic
ADediting_175070	chr10_126921150_+	intronic
ADediting_175071	chr10_126921722_+	intronic
ADediting_175072	chr10_126921732_+	intronic
ADediting_175073	chr10_126921739_+	intronic
ADediting_175074	chr10_126921752_+	intronic
ADediting_175075	chr10_126921753_+	intronic
ADediting_175076	chr10_126921782_+	intronic
ADediting_175077	chr10_126921794_+	intronic
ADediting_175078	chr10_126921798_+	intronic
ADediting_175079	chr10_126921802_+	intronic
ADediting_175080	chr10_126921832_+	intronic
ADediting_175081	chr10_126921861_+	intronic
ADediting_175082	chr10_126922016_+	intronic
ADediting_175083	chr10_126922021_+	intronic
ADediting_175084	chr10_126922026_+	intronic
ADediting_175085	chr10_126922047_+	intronic
ADediting_175086	chr10_126922065_+	intronic
ADediting_175087	chr10_126922069_+	intronic
ADediting_175088	chr10_126922081_+	intronic
ADediting_175089	chr10_126922085_+	intronic
ADediting_175090	chr10_126922091_+	intronic
ADediting_175091	chr10_126922097_+	intronic
ADediting_175092	chr10_126922105_+	intronic
ADediting_175093	chr10_126922106_+	intronic
ADediting_175094	chr10_126922107_+	intronic
ADediting_175095	chr10_126922121_+	intronic
ADediting_175096	chr10_126922146_+	intronic
ADediting_175097	chr10_126923015_+	intronic
ADediting_175098	chr10_126923477_+	intronic
ADediting_175099	chr10_126923493_+	intronic
ADediting_175100	chr10_126925453_+	intronic
ADediting_175134	chr10_127036718_+	intronic
ADediting_175135	chr10_127036745_+	intronic
ADediting_175137	chr10_127051638_+	intronic
ADediting_175138	chr10_127051641_+	intronic
ADediting_175139	chr10_127051683_+	intronic
ADediting_175140	chr10_127051716_+	intronic
ADediting_175141	chr10_127051748_+	intronic
ADediting_175142	chr10_127051792_+	intronic
ADediting_175143	chr10_127052276_+	intronic
ADediting_175144	chr10_127052401_+	intronic
ADediting_175145	chr10_127052404_+	intronic
ADediting_175146	chr10_127052410_+	intronic
ADediting_175147	chr10_127069435_+	intronic
ADediting_175148	chr10_127074990_+	intronic
ADediting_175149	chr10_127074993_+	intronic
ADediting_175150	chr10_127075005_+	intronic
ADediting_175151	chr10_127075022_+	intronic
ADediting_175152	chr10_127075058_+	intronic
ADediting_175153	chr10_127075071_+	intronic
ADediting_175154	chr10_127075075_+	intronic
ADediting_175155	chr10_127075372_+	intronic
ADediting_175156	chr10_127075389_+	intronic
ADediting_175157	chr10_127075397_+	intronic
ADediting_175158	chr10_127075398_+	intronic
ADediting_175159	chr10_127075401_+	intronic
ADediting_175160	chr10_127075647_+	intronic
ADediting_175199	chr10_127224359_+	intronic
ADediting_175200	chr10_127224626_+	intronic
ADediting_175220	chr10_127250615_+	intronic
ADediting_175221	chr10_127250626_+	intronic
ADediting_175222	chr10_127250648_+	intronic
ADediting_175223	chr10_127250671_+	intronic
ADediting_175224	chr10_127250672_+	intronic
ADediting_175225	chr10_127250698_+	intronic
ADediting_175226	chr10_127250713_+	intronic
ADediting_175228	chr10_127251019_+	intronic
ADediting_175229	chr10_127251026_+	intronic
ADediting_175230	chr10_127251027_+	intronic
ADediting_175231	chr10_127251040_+	intronic
ADediting_175232	chr10_127251063_+	intronic
ADediting_175233	chr10_127251080_+	intronic
ADediting_175234	chr10_127251102_+	intronic
ADediting_175235	chr10_127251128_+	intronic
ADediting_175236	chr10_127251150_+	intronic
ADediting_175237	chr10_127251195_+	intronic
ADediting_175238	chr10_127251259_+	intronic
ADediting_175279	chr10_127266564_+	intronic
ADediting_175280	chr10_127266571_+	intronic
ADediting_175281	chr10_127266597_+	intronic
ADediting_175282	chr10_127266599_+	intronic
ADediting_175283	chr10_127266600_+	intronic
ADediting_175284	chr10_127266605_+	intronic
ADediting_175285	chr10_127266606_+	intronic
ADediting_175286	chr10_127266624_+	intronic
ADediting_175287	chr10_127266625_+	intronic
ADediting_175288	chr10_127267676_+	intronic
ADediting_175289	chr10_127267677_+	intronic
ADediting_175290	chr10_127267701_+	intronic
ADediting_175291	chr10_127267704_+	intronic
ADediting_175292	chr10_127268393_+	intronic
ADediting_175307	chr10_127388120_+	intronic
ADediting_175327	chr10_127411508_+	intronic
ADediting_175328	chr10_127411579_+	intronic
ADediting_175329	chr10_127411585_+	intronic
ADediting_175330	chr10_127411586_+	intronic
ADediting_175331	chr10_127411591_+	intronic
ADediting_175332	chr10_127411592_+	intronic
ADediting_175333	chr10_127411612_+	intronic
ADediting_175334	chr10_127411645_+	intronic
ADediting_175335	chr10_127411654_+	intronic
ADediting_175336	chr10_127411655_+	intronic
ADediting_175337	chr10_127411657_+	intronic
ADediting_175338	chr10_127411662_+	intronic
ADediting_175339	chr10_127411663_+	intronic
ADediting_175340	chr10_127411676_+	intronic
ADediting_175341	chr10_127411679_+	intronic
ADediting_175342	chr10_127411681_+	intronic
ADediting_175343	chr10_127411682_+	intronic
ADediting_175344	chr10_127411719_+	intronic
ADediting_175345	chr10_127411720_+	intronic
ADediting_175346	chr10_127411761_+	intronic
ADediting_175347	chr10_127411765_+	intronic
ADediting_175348	chr10_127411789_+	intronic
ADediting_175349	chr10_127411986_+	intronic
ADediting_175350	chr10_127412032_+	intronic
ADediting_175351	chr10_127412043_+	intronic
ADediting_175352	chr10_127412056_+	intronic
ADediting_175353	chr10_127412089_+	intronic
ADediting_175354	chr10_127412147_+	intronic
ADediting_175355	chr10_127412161_+	intronic
ADediting_175356	chr10_127412169_+	intronic
ADediting_175357	chr10_127412236_+	intronic
ADediting_175358	chr10_127413981_+	intronic
ADediting_175359	chr10_127414006_+	intronic
ADediting_175360	chr10_127414012_+	intronic
ADediting_175361	chr10_127414022_+	intronic
ADediting_175362	chr10_127414029_+	intronic
ADediting_175363	chr10_127414046_+	intronic
ADediting_175364	chr10_127414078_+	intronic
ADediting_175365	chr10_127414104_+	intronic
ADediting_175366	chr10_127414112_+	intronic
ADediting_175367	chr10_127414173_+	intronic
ADediting_175368	chr10_127414174_+	intronic
ADediting_1522833	chr10_127075305_+	intronic
ADediting_1522834	chr10_127412757_+	intronic
ADediting_1522835	chr10_127414011_+	intronic
ADediting_1522836	chr10_127414051_+	intronic
ADediting_1522837	chr10_127414069_+	intronic
ADediting_1522838	chr10_127414077_+	intronic
ADediting_1604396	chr10_126985906_+	intronic
ADediting_1604400	chr10_127321917_+	intronic
ADediting_1604401	chr10_127321927_+	intronic
ADediting_1604402	chr10_127321976_+	intronic
ADediting_1604403	chr10_127321983_+	intronic
ADediting_1604404	chr10_127321992_+	intronic
ADediting_1604405	chr10_127322038_+	intronic
ADediting_1604406	chr10_127322048_+	intronic
ADediting_1604407	chr10_127322238_+	intronic
ADediting_1604408	chr10_127322282_+	intronic
ADediting_1604409	chr10_127322290_+	intronic
ADediting_1604410	chr10_127322319_+	intronic
ADediting_1604411	chr10_127322329_+	intronic
ADediting_1604412	chr10_127322335_+	intronic
ADediting_1604413	chr10_127322370_+	intronic
ADediting_1604414	chr10_127322395_+	intronic
ADediting_1604415	chr10_127322399_+	intronic
ADediting_1604416	chr10_127322425_+	intronic
ADediting_1604417	chr10_127322442_+	intronic
ADediting_1604418	chr10_127322463_+	intronic
ADediting_1604419	chr10_127322465_+	intronic
ADediting_1604421	chr10_127414186_+	intronic

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_175030	chr10_126912145_+	LTR	ERVL-MaLR	Name=MLT1B
ADediting_175031	chr10_126912167_+	SINE	Alu	Name=AluSq2
ADediting_175032	chr10_126912174_+	SINE	Alu	Name=AluSq2
ADediting_175033	chr10_126912214_+	SINE	Alu	Name=AluSq2
ADediting_175034	chr10_126912310_+	SINE	Alu	Name=AluSq2
ADediting_175035	chr10_126912319_+	SINE	Alu	Name=AluSq2
ADediting_175036	chr10_126912345_+	SINE	Alu	Name=AluSq2
ADediting_175037	chr10_126912380_+	SINE	Alu	Name=AluSq2
ADediting_175038	chr10_126914451_+	SINE	Alu	Name=AluJr
ADediting_175039	chr10_126914496_+	SINE	Alu	Name=AluJr
ADediting_175044	chr10_126915480_+	SINE	Alu	Name=AluSc8
ADediting_175045	chr10_126915482_+	SINE	Alu	Name=AluSc8
ADediting_175046	chr10_126915483_+	SINE	Alu	Name=AluSc8
ADediting_175047	chr10_126915519_+	SINE	Alu	Name=AluSc8
ADediting_175048	chr10_126915522_+	SINE	Alu	Name=AluSc8
ADediting_175049	chr10_126915545_+	SINE	Alu	Name=AluSc8
ADediting_175050	chr10_126915548_+	SINE	Alu	Name=AluSc8
ADediting_175051	chr10_126915558_+	SINE	Alu	Name=AluSc8
ADediting_175052	chr10_126915568_+	SINE	Alu	Name=AluSc8
ADediting_175053	chr10_126915571_+	SINE	Alu	Name=AluSc8
ADediting_175056	chr10_126915658_+	SINE	Alu	Name=AluSc8
ADediting_175057	chr10_126915725_+	SINE	Alu	Name=AluSc8
ADediting_175060	chr10_126921011_+	SINE	Alu	Name=AluSx
ADediting_175061	chr10_126921013_+	SINE	Alu	Name=AluSx
ADediting_175062	chr10_126921021_+	SINE	Alu	Name=AluSx
ADediting_175063	chr10_126921079_+	SINE	Alu	Name=AluSx
ADediting_175064	chr10_126921080_+	SINE	Alu	Name=AluSx
ADediting_175065	chr10_126921082_+	SINE	Alu	Name=AluSx
ADediting_175066	chr10_126921106_+	SINE	Alu	Name=AluSx
ADediting_175067	chr10_126921115_+	SINE	Alu	Name=AluSx
ADediting_175068	chr10_126921132_+	SINE	Alu	Name=AluSx
ADediting_175069	chr10_126921145_+	SINE	Alu	Name=AluSx
ADediting_175070	chr10_126921150_+	SINE	Alu	Name=AluSx
ADediting_175071	chr10_126921722_+	SINE	Alu	Name=AluSx
ADediting_175072	chr10_126921732_+	SINE	Alu	Name=AluSx
ADediting_175073	chr10_126921739_+	SINE	Alu	Name=AluSx
ADediting_175074	chr10_126921752_+	SINE	Alu	Name=AluSx
ADediting_175075	chr10_126921753_+	SINE	Alu	Name=AluSx
ADediting_175076	chr10_126921782_+	SINE	Alu	Name=AluSx
ADediting_175077	chr10_126921794_+	SINE	Alu	Name=AluSx
ADediting_175078	chr10_126921798_+	SINE	Alu	Name=AluSx
ADediting_175079	chr10_126921802_+	SINE	Alu	Name=AluSx
ADediting_175080	chr10_126921832_+	SINE	Alu	Name=AluSx
ADediting_175081	chr10_126921861_+	SINE	Alu	Name=AluSx
ADediting_175082	chr10_126922016_+	SINE	Alu	Name=AluJb
ADediting_175083	chr10_126922021_+	SINE	Alu	Name=AluJb
ADediting_175084	chr10_126922026_+	SINE	Alu	Name=AluJb
ADediting_175085	chr10_126922047_+	SINE	Alu	Name=AluJb
ADediting_175086	chr10_126922065_+	SINE	Alu	Name=AluJb
ADediting_175087	chr10_126922069_+	SINE	Alu	Name=AluJb
ADediting_175088	chr10_126922081_+	SINE	Alu	Name=AluJb
ADediting_175089	chr10_126922085_+	SINE	Alu	Name=AluJb
ADediting_175090	chr10_126922091_+	SINE	Alu	Name=AluJb
ADediting_175091	chr10_126922097_+	SINE	Alu	Name=AluJb
ADediting_175092	chr10_126922105_+	SINE	Alu	Name=AluJb
ADediting_175093	chr10_126922106_+	SINE	Alu	Name=AluJb
ADediting_175094	chr10_126922107_+	SINE	Alu	Name=AluJb
ADediting_175095	chr10_126922121_+	SINE	Alu	Name=AluJb
ADediting_175096	chr10_126922146_+	SINE	Alu	Name=AluJb
ADediting_175097	chr10_126923015_+	SINE	Alu	Name=AluSp
ADediting_175098	chr10_126923477_+	SINE	Alu	Name=AluSx1
ADediting_175099	chr10_126923493_+	SINE	Alu	Name=AluSx1
ADediting_175100	chr10_126925453_+	SINE	Alu	Name=AluSc
ADediting_175134	chr10_127036718_+	SINE	Alu	Name=AluSq2
ADediting_175135	chr10_127036745_+	SINE	Alu	Name=AluSq2
ADediting_175137	chr10_127051638_+	SINE	Alu	Name=AluJb
ADediting_175138	chr10_127051641_+	SINE	Alu	Name=AluJb
ADediting_175139	chr10_127051683_+	SINE	Alu	Name=AluJb
ADediting_175140	chr10_127051716_+	SINE	Alu	Name=AluJb
ADediting_175141	chr10_127051748_+	SINE	Alu	Name=AluJb
ADediting_175142	chr10_127051792_+	SINE	Alu	Name=AluJb
ADediting_175143	chr10_127052276_+	SINE	Alu	Name=AluSx
ADediting_175144	chr10_127052401_+	SINE	Alu	Name=AluSx
ADediting_175145	chr10_127052404_+	SINE	Alu	Name=AluSx
ADediting_175146	chr10_127052410_+	SINE	Alu	Name=AluSx
ADediting_175148	chr10_127074990_+	SINE	Alu	Name=AluSp
ADediting_175149	chr10_127074993_+	SINE	Alu	Name=AluSp
ADediting_175150	chr10_127075005_+	SINE	Alu	Name=AluSp
ADediting_175151	chr10_127075022_+	SINE	Alu	Name=AluSp
ADediting_175152	chr10_127075058_+	SINE	Alu	Name=AluSp
ADediting_175153	chr10_127075071_+	SINE	Alu	Name=AluSp
ADediting_175154	chr10_127075075_+	SINE	Alu	Name=AluSp
ADediting_175155	chr10_127075372_+	SINE	Alu	Name=AluJb
ADediting_175156	chr10_127075389_+	SINE	Alu	Name=AluJb
ADediting_175157	chr10_127075397_+	SINE	Alu	Name=AluJb
ADediting_175158	chr10_127075398_+	SINE	Alu	Name=AluJb
ADediting_175159	chr10_127075401_+	SINE	Alu	Name=AluJb
ADediting_175160	chr10_127075647_+	LTR	ERVL-MaLR	Name=THE1D
ADediting_175199	chr10_127224359_+	SINE	Alu	Name=AluSz
ADediting_175200	chr10_127224626_+	SINE	Alu	Name=AluJb
ADediting_175220	chr10_127250615_+	SINE	Alu	Name=AluSx1
ADediting_175221	chr10_127250626_+	SINE	Alu	Name=AluSx1
ADediting_175222	chr10_127250648_+	SINE	Alu	Name=AluSx1
ADediting_175223	chr10_127250671_+	SINE	Alu	Name=AluSx1
ADediting_175224	chr10_127250672_+	SINE	Alu	Name=AluSx1
ADediting_175225	chr10_127250698_+	SINE	Alu	Name=AluSx1
ADediting_175226	chr10_127250713_+	SINE	Alu	Name=AluSx1
ADediting_175228	chr10_127251019_+	SINE	Alu	Name=AluSp
ADediting_175229	chr10_127251026_+	SINE	Alu	Name=AluSp
ADediting_175230	chr10_127251027_+	SINE	Alu	Name=AluSp
ADediting_175231	chr10_127251040_+	SINE	Alu	Name=AluSp
ADediting_175232	chr10_127251063_+	SINE	Alu	Name=AluSp
ADediting_175233	chr10_127251080_+	SINE	Alu	Name=AluSp
ADediting_175234	chr10_127251102_+	SINE	Alu	Name=AluSp
ADediting_175235	chr10_127251128_+	SINE	Alu	Name=AluSp
ADediting_175236	chr10_127251150_+	SINE	Alu	Name=AluSp
ADediting_175237	chr10_127251195_+	SINE	Alu	Name=AluSp
ADediting_175238	chr10_127251259_+	SINE	Alu	Name=AluSp
ADediting_175292	chr10_127268393_+	SINE	Alu	Name=AluSx3
ADediting_175327	chr10_127411508_+	DNA	hAT-Charlie	Name=MER20
ADediting_175328	chr10_127411579_+	SINE	Alu	Name=AluSq2
ADediting_175329	chr10_127411585_+	SINE	Alu	Name=AluSq2
ADediting_175330	chr10_127411586_+	SINE	Alu	Name=AluSq2
ADediting_175331	chr10_127411591_+	SINE	Alu	Name=AluSq2
ADediting_175332	chr10_127411592_+	SINE	Alu	Name=AluSq2
ADediting_175333	chr10_127411612_+	SINE	Alu	Name=AluSq2
ADediting_175334	chr10_127411645_+	SINE	Alu	Name=AluSq2
ADediting_175335	chr10_127411654_+	SINE	Alu	Name=AluSq2
ADediting_175336	chr10_127411655_+	SINE	Alu	Name=AluSq2
ADediting_175337	chr10_127411657_+	SINE	Alu	Name=AluSq2
ADediting_175338	chr10_127411662_+	SINE	Alu	Name=AluSq2
ADediting_175339	chr10_127411663_+	SINE	Alu	Name=AluSq2
ADediting_175340	chr10_127411676_+	SINE	Alu	Name=AluSq2
ADediting_175341	chr10_127411679_+	SINE	Alu	Name=AluSq2
ADediting_175342	chr10_127411681_+	SINE	Alu	Name=AluSq2
ADediting_175343	chr10_127411682_+	SINE	Alu	Name=AluSq2
ADediting_175344	chr10_127411719_+	SINE	Alu	Name=AluSq2
ADediting_175345	chr10_127411720_+	SINE	Alu	Name=AluSq2
ADediting_175346	chr10_127411761_+	SINE	Alu	Name=AluSq2
ADediting_175347	chr10_127411765_+	SINE	Alu	Name=AluSq2
ADediting_175348	chr10_127411789_+	SINE	Alu	Name=AluSq2
ADediting_175349	chr10_127411986_+	SINE	Alu	Name=AluY
ADediting_175350	chr10_127412032_+	SINE	Alu	Name=AluY
ADediting_175351	chr10_127412043_+	SINE	Alu	Name=AluY
ADediting_175352	chr10_127412056_+	SINE	Alu	Name=AluY
ADediting_175353	chr10_127412089_+	SINE	Alu	Name=AluY
ADediting_175354	chr10_127412147_+	SINE	Alu	Name=AluY
ADediting_175355	chr10_127412161_+	SINE	Alu	Name=AluY
ADediting_175356	chr10_127412169_+	SINE	Alu	Name=AluY
ADediting_175357	chr10_127412236_+	SINE	Alu	Name=AluY
ADediting_175358	chr10_127413981_+	SINE	Alu	Name=AluSz6
ADediting_175359	chr10_127414006_+	SINE	Alu	Name=AluSz6
ADediting_175360	chr10_127414012_+	SINE	Alu	Name=AluSz6
ADediting_175361	chr10_127414022_+	SINE	Alu	Name=AluSz6
ADediting_175362	chr10_127414029_+	SINE	Alu	Name=AluSz6
ADediting_175363	chr10_127414046_+	SINE	Alu	Name=AluSz6
ADediting_175364	chr10_127414078_+	SINE	Alu	Name=AluSz6
ADediting_175365	chr10_127414104_+	SINE	Alu	Name=AluSz6
ADediting_175366	chr10_127414112_+	SINE	Alu	Name=AluSz6
ADediting_175367	chr10_127414173_+	SINE	Alu	Name=AluSz6
ADediting_175368	chr10_127414174_+	SINE	Alu	Name=AluSz6
ADediting_1522833	chr10_127075305_+	SINE	Alu	Name=AluJb
ADediting_1522835	chr10_127414011_+	SINE	Alu	Name=AluSz6
ADediting_1522836	chr10_127414051_+	SINE	Alu	Name=AluSz6
ADediting_1522837	chr10_127414069_+	SINE	Alu	Name=AluSz6
ADediting_1522838	chr10_127414077_+	SINE	Alu	Name=AluSz6
ADediting_1604396	chr10_126985906_+	SINE	Alu	Name=AluSx3
ADediting_1604400	chr10_127321917_+	SINE	Alu	Name=AluSx
ADediting_1604401	chr10_127321927_+	SINE	Alu	Name=AluSx
ADediting_1604402	chr10_127321976_+	SINE	Alu	Name=AluSx
ADediting_1604403	chr10_127321983_+	SINE	Alu	Name=AluSx
ADediting_1604404	chr10_127321992_+	SINE	Alu	Name=AluSx
ADediting_1604405	chr10_127322038_+	SINE	Alu	Name=AluSx
ADediting_1604406	chr10_127322048_+	SINE	Alu	Name=AluSx
ADediting_1604407	chr10_127322238_+	SINE	Alu	Name=AluSz
ADediting_1604408	chr10_127322282_+	SINE	Alu	Name=AluSz
ADediting_1604409	chr10_127322290_+	SINE	Alu	Name=AluSz
ADediting_1604410	chr10_127322319_+	SINE	Alu	Name=AluSz
ADediting_1604411	chr10_127322329_+	SINE	Alu	Name=AluSz
ADediting_1604412	chr10_127322335_+	SINE	Alu	Name=AluSz
ADediting_1604413	chr10_127322370_+	SINE	Alu	Name=AluSz
ADediting_1604414	chr10_127322395_+	SINE	Alu	Name=AluSz
ADediting_1604415	chr10_127322399_+	SINE	Alu	Name=AluSz
ADediting_1604416	chr10_127322425_+	SINE	Alu	Name=AluSz
ADediting_1604417	chr10_127322442_+	SINE	Alu	Name=AluSz
ADediting_1604418	chr10_127322463_+	SINE	Alu	Name=AluSz
ADediting_1604419	chr10_127322465_+	SINE	Alu	Name=AluSz
ADediting_1604421	chr10_127414186_+	SINE	Alu	Name=AluSz6

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RNA A-to-I editing events in the alternative splicing sites for DOCK1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

ADeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for DOCK1

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

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Protein coding region RNA A-to-I editings for DOCK1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for DOCK1

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_1337757

chr7_5495852_-

ENSG00000150760.12

ENST00000280333.9

DOCK1-201

hsa-miR-589-3p

chr10

127451766

127451773

8mer-1a

127451752

127451773

156

-19.26

ADediting_1535951

chr14_100874558_+

ENSG00000150760.12

ENST00000280333.9

DOCK1-201

hsa-miR-337-3p

chr10

127452080

127452087

8mer-1a

127452065

127452087

151

-12.93

ADediting_1535953

chr14_101045971_+

ENSG00000150760.12

ENST00000280333.9

DOCK1-201

hsa-miR-381-3p

chr10

127451743

127451749

7mer-m8

127451729

127451750

140

-12.12

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for DOCK1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID

ENST

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in lncRNA.

ADeditom_ID

ENST

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for DOCK1

Correlation between ADAR gene expression and RNA editing frequency

Tissue	ADeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	ADediting_175062	chr10_126921021_+	0.607879838026287	0.0292541879124529	0.124916920445884	-0.0873375928094214	5.37921645496781e-11	0.361378659229636
DLPFC	ADediting_175076	chr10_126921782_+	0.607722810782982	0.0292669825276786	0.0329634871709482	-0.121162346129749	1.15962834443901e-21	0.507129072034447
DLPFC	ADediting_175078	chr10_126921798_+	0.236766642828428	-0.0673918062985709	0.0113150549633971	-0.143687476250587	1.21176206067511e-09	0.336486088392985
DLPFC	ADediting_175079	chr10_126921802_+	0.509336344210536	-0.037616874360714	0.0158477340304332	-0.136922538186579	3.85849988441269e-11	0.363910334647678
DLPFC	ADediting_175086	chr10_126922065_+	0.3064684321381	-0.0582692377567337	0.0595617370991469	-0.10713001074095	1.3915244696014e-08	0.315301863745752
DLPFC	ADediting_175088	chr10_126922081_+	0.171757772439054	-0.0778130034059836	0.0502545914294437	-0.111298952086557	6.38215586187713e-08	0.301194730872909
DLPFC	ADediting_175092	chr10_126922105_+	0.308828766946266	-0.0579860960423106	0.0383695387171178	-0.117684773109868	9.31607255378832e-17	0.448636459258107
DLPFC	ADediting_175093	chr10_126922106_+	0.548011567303073	-0.0342482194790159	0.160654702693224	-0.0798731504893179	2.38973879932485e-12	0.384281319202049
DLPFC	ADediting_175228	chr10_127251019_+	0.704998844816689	-0.0215866694476523	0.0213289356285962	-0.130717663445844	2.81735397754182e-14	0.414138277883948
TCX	ADediting_175328	chr10_127411579_+	0.906637885832568	-0.00965645926491375	0.0334951526459917	-0.173726154947753	8.65781394362396e-05	0.314948337495092
TCX	ADediting_175330	chr10_127411586_+	0.931783899557689	0.007048136303488	0.0328662763390815	-0.174338900148804	0.000158459937855221	0.303650577187777

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
AC	8.96174204198456e-40	0.710824110057521	1.29424143414989e-23	0.577266197751611	1.87515339058857e-32	0.658465122797203
PCC	0.0115921105612556	0.1823169564303	0.117042257511798	0.113784860974787	3.18082224252628e-10	0.435087463397585
CER	6.17475163120702e-09	0.452399994606971	0.000150342552391723	0.304651756315281	1.35725530546276e-13	0.556896942977462
TCX	0.101494717381718	0.134230626218914	4.79218077387011e-07	-0.397333968051281	8.16006787420616e-27	0.735618711956545
FP	3.76683430412578e-05	0.303717925283787	0.262534667142456	0.0844238265937148	1.15454160221068e-20	0.62482792198196
IFG	0.183840194462178	0.274721168037202	0.698464157740051	0.0815234207493316	1.19735538823934e-06	0.805351970727326
PG	1.51321217081287e-22	0.63683122099814	4.70233974837381e-07	0.359413584968568	2.76419472732492e-05	0.302197178878212
STG	0.00126452295963453	0.346009572338106	0.441253685031792	0.0851454493936188	1.05667952932865e-09	0.605415839943729

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Relation with AD stages for DOCK1

Correlation between AD stages and RNA editing frequency

Tissue

ADeditomID

position

P-val

Coeff.

Correlation between AD stages and this gene's expression

Tissue	P-val	Coeff.
CER	4.03698268436429e-05	0.384233560944928
TCX	2.89551134479235e-07	0.473818896112363
IFG	0.0298191916722321	0.434875258060497
PG	3.0740900350326e-06	0.334463690867159

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RelatedDrugs for DOCK1

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for DOCK1

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
DOCK1	C0013146	Drug abuse	1	CTD_human
DOCK1	C0013170	Drug habituation	1	CTD_human
DOCK1	C0013222	Drug Use Disorders	1	CTD_human
DOCK1	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
DOCK1	C0038580	Substance Dependence	1	CTD_human
DOCK1	C0038586	Substance Use Disorders	1	CTD_human
DOCK1	C0236969	Substance-Related Disorders	1	CTD_human
DOCK1	C0740858	Substance abuse problem	1	CTD_human
DOCK1	C1510472	Drug Dependence	1	CTD_human
DOCK1	C4316881	Prescription Drug Abuse	1	CTD_human

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Gene summary for DOCK1

RNA A-to-I events for DOCK1

RNA editing positional annotations for DOCK1 using Annovar

RNA A-to-I editing events in the alternative splicing sites for DOCK1

Differntial gene expression between RNA A-to-I edited versus non-edited samples for DOCK1

Protein coding region RNA A-to-I editings for DOCK1

The effects of the RNA editing to the miRNA binding sites for DOCK1

The effects of the RNA editing to the stability of the RNA structures for DOCK1

Relation with ADAR for DOCK1

Relation with AD stages for DOCK1

RelatedDrugs for DOCK1

RelatedDiseases for DOCK1

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene