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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for ADGRA3 |
 Gene summary |
| Gene information | Gene symbol | ADGRA3 | Gene ID | 166647 |
| Gene name | adhesion G protein-coupled receptor A3 | |
| Synonyms | GPR125|PGR21|TEM5L | |
| Cytomap | 4p15.2 | |
| Type of gene | protein-coding | |
| Description | adhesion G protein-coupled receptor A3G-protein coupled receptor 125probable G-protein coupled receptor 125 | |
| Modification date | 20200313 | |
| UniProtAcc | Q8IWK6, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for ADGRA3 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1125177(22377572, -), ADediting_1125178(22377628, -), ADediting_1125179(22412646, -), ADediting_1125180(22429095, -), ADediting_1125181(22429156, -), ADediting_1125182(22476807, -), ADediting_1125183(22485178, -), ADediting_1125184(22511964, -), ADediting_1125185(22511965, -), ADediting_1125186(22511993, -), ADediting_1125187(22512038, -), ADediting_1125188(22512039, -), ADediting_1125189(22512104, -), ADediting_1125190(22512105, -), ADediting_1125191(22513420, -), ADediting_1125192(22513791, -), ADediting_1651591(22429032, -), ADediting_1651592(22429061, -), ADediting_1651593(22462452, -), |
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RNA editing positional annotations for ADGRA3 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1125177 | chr4_22377572_- | intronic |
| ADediting_1125178 | chr4_22377628_- | intronic |
| ADediting_1125179 | chr4_22412646_- | intronic |
| ADediting_1125180 | chr4_22429095_- | intronic |
| ADediting_1125181 | chr4_22429156_- | intronic |
| ADediting_1125182 | chr4_22476807_- | intronic |
| ADediting_1125183 | chr4_22485178_- | intronic |
| ADediting_1125184 | chr4_22511964_- | intronic |
| ADediting_1125185 | chr4_22511965_- | intronic |
| ADediting_1125186 | chr4_22511993_- | intronic |
| ADediting_1125187 | chr4_22512038_- | intronic |
| ADediting_1125188 | chr4_22512039_- | intronic |
| ADediting_1125189 | chr4_22512104_- | intronic |
| ADediting_1125190 | chr4_22512105_- | intronic |
| ADediting_1125191 | chr4_22513420_- | intronic |
| ADediting_1125192 | chr4_22513791_- | intronic |
| ADediting_1651591 | chr4_22429032_- | intronic |
| ADediting_1651592 | chr4_22429061_- | intronic |
| ADediting_1651593 | chr4_22462452_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1125177 | chr4_22377572_- | LINE | L1 | Name=L1P3 |
| ADediting_1125178 | chr4_22377628_- | LINE | L1 | Name=L1P3 |
| ADediting_1125182 | chr4_22476807_- | SINE | Alu | Name=AluSq |
| ADediting_1125183 | chr4_22485178_- | SINE | Alu | Name=AluSz6 |
| ADediting_1125184 | chr4_22511964_- | SINE | Alu | Name=AluSz |
| ADediting_1125185 | chr4_22511965_- | SINE | Alu | Name=AluSz |
| ADediting_1125186 | chr4_22511993_- | SINE | Alu | Name=AluSz |
| ADediting_1125187 | chr4_22512038_- | SINE | Alu | Name=AluSz |
| ADediting_1125188 | chr4_22512039_- | SINE | Alu | Name=AluSz |
| ADediting_1125189 | chr4_22512104_- | SINE | Alu | Name=AluSz |
| ADediting_1125190 | chr4_22512105_- | SINE | Alu | Name=AluSz |
| ADediting_1125191 | chr4_22513420_- | SINE | Alu | Name=AluSq2 |
| ADediting_1125192 | chr4_22513791_- | SINE | Alu | Name=AluSz |
| ADediting_1651593 | chr4_22462452_- | SINE | Alu | Name=AluSz6 |
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RNA A-to-I editing events in the alternative splicing sites for ADGRA3 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ADGRA3 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for ADGRA3 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for ADGRA3 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000152990.14 | ENST00000508133.5 | ADGRA3-209 | hsa-miR-4477b | chr4 | 22414435 | 22414441 | 7mer-m8 | 22414434 | 22414453 | 153 | -11.32 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000152990.14 | ENST00000502482.1 | ADGRA3-204 | hsa-miR-589-3p | chr4 | 22420821 | 22420827 | 7mer-m8 | 22420820 | 22420843 | 150 | -11.47 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000152990.14 | ENST00000508133.5 | ADGRA3-209 | hsa-miR-4477b | chr4 | 22414238 | 22414244 | 7mer-1a | 22414238 | 22414259 | 146 | -14.88 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000152990.14 | ENST00000508133.5 | ADGRA3-209 | hsa-miR-4477b | chr4 | 22414238 | 22414244 | 7mer-1a | 22414238 | 22414259 | 146 | -14.88 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000152990.14 | ENST00000334304.10 | ADGRA3-202 | hsa-miR-381-3p | chr4 | 22387409 | 22387415 | 7mer-m8 | 22387408 | 22387429 | 140 | -9.43 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000152990.14 | ENST00000334304.10 | ADGRA3-202 | hsa-miR-381-3p | chr4 | 22387409 | 22387415 | 7mer-m8 | 22387408 | 22387429 | 140 | -9.43 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for ADGRA3 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for ADGRA3 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| AC | ADediting_1125179 | chr4_22412646_- | 4.7420494707159e-09 | 0.359697191364546 | 1.28691615313823e-07 | 0.32642349854295 | 4.04806320065349e-06 | 0.286783647952061 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| AC | 1.71958031558671e-42 | 0.72768416368555 | 1.9571623693688e-24 | 0.585867060234016 | 2.33140637680656e-20 | 0.540418146076394 |
| PCC | 5.82808567253044e-05 | 0.286608714262795 | 0.00543847497924567 | 0.200413309780002 | 5.28457687538058e-08 | 0.381259416752295 |
| CER | 8.45406200585687e-09 | 0.448736540946403 | 0.00235092793946804 | 0.246585716528423 | 5.22005452805045e-14 | 0.564678960807373 |
| TCX | 0.000472047244364667 | 0.282001349322176 | 0.864085959607243 | -0.0140936070929904 | 5.1389445463291e-06 | 0.362533145573589 |
| FP | 3.85189107395676e-08 | 0.397731093644391 | 1.43893725496141e-07 | 0.381911542932001 | 4.80483444103486e-19 | 0.603548051409307 |
| IFG | 0.00189685209900071 | 0.59024126938573 | 0.000240543237384616 | 0.671093412267239 | 0.000380083554512877 | 0.655044298173892 |
| PG | 2.34479660830778e-21 | 0.622676185389619 | 4.929400214201e-11 | 0.458010880620725 | 0.0366291854958453 | 0.153363098376393 |
| STG | 0.0113010421321294 | 0.27516539474429 | 0.0193262898252356 | 0.254814675933054 | 3.16896351277001e-07 | 0.523810650124287 |
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Relation with AD stages for ADGRA3 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 5.29931038354109e-05 | 0.378756903908149 |
| TCX | 1.33676297889586e-09 | 0.546716987514329 |
| IFG | 0.0357740866739002 | 0.421676333628955 |
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RelatedDrugs for ADGRA3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ADGRA3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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