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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for DHX15 |
 Gene summary |
| Gene information | Gene symbol | DHX15 | Gene ID | 1665 |
| Gene name | DEAH-box helicase 15 | |
| Synonyms | DBP1|DDX15|HRH2|PRP43|PRPF43|PrPp43p | |
| Cytomap | 4p15.2 | |
| Type of gene | protein-coding | |
| Description | pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15ATP-dependent RNA helicase #46DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15DEAD/H box-15DEAH (Asp-Glu-Ala-His) box helicase 15DEAH (Asp-Glu-Ala-His) box polypeptide 15DEAH box protein 15RNA | |
| Modification date | 20200313 | |
| UniProtAcc | O43143, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for DHX15 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1125586(24525919, -), ADediting_1125587(24530343, -), ADediting_1125588(24530465, -), ADediting_1125589(24530490, -), ADediting_1125590(24530495, -), ADediting_1125591(24530525, -), ADediting_1125592(24530576, -), ADediting_1125593(24531186, -), ADediting_1125594(24531221, -), ADediting_1125595(24531227, -), ADediting_1125596(24531253, -), ADediting_1125597(24531291, -), ADediting_1125598(24531316, -), ADediting_1125599(24531355, -), ADediting_1125600(24531360, -), ADediting_1125601(24531361, -), ADediting_1125602(24531456, -), ADediting_1125603(24531461, -), ADediting_1125604(24531468, -), ADediting_1125605(24531469, -), ADediting_1125606(24531541, -), ADediting_1125607(24531594, -), ADediting_1125608(24531596, -), ADediting_1125609(24531623, -), ADediting_1125610(24531650, -), ADediting_1125611(24531669, -), ADediting_1125612(24531672, -), ADediting_1125613(24531699, -), ADediting_1125614(24531706, -), ADediting_1125615(24531707, -), ADediting_1125617(24547700, -), ADediting_1125618(24548294, -), ADediting_1125619(24548410, -), ADediting_1125620(24548415, -), ADediting_1125621(24548416, -), ADediting_1125622(24566135, -), ADediting_1125623(24566136, -), ADediting_1125624(24566146, -), ADediting_1125625(24566154, -), ADediting_1125626(24566178, -), ADediting_1125627(24566200, -), ADediting_1125628(24566302, -), ADediting_1125629(24566309, -), ADediting_1125630(24566315, -), ADediting_1125631(24566581, -), ADediting_1125632(24566591, -), ADediting_1125633(24566596, -), ADediting_1125634(24566608, -), ADediting_1125635(24566621, -), ADediting_1125636(24566622, -), ADediting_1125637(24566623, -), ADediting_1125638(24566682, -), ADediting_1125639(24572219, -), ADediting_1125640(24572409, -), ADediting_1125641(24572411, -), ADediting_1125642(24580324, -), ADediting_1577126(24530405, -), ADediting_1577127(24530415, -), ADediting_1577128(24531002, -), ADediting_1577129(24531283, -), ADediting_1577130(24531293, -), ADediting_1577131(24531494, -), ADediting_1577132(24531515, -), ADediting_1577133(24531530, -), ADediting_1651621(24530468, -), ADediting_1651622(24566282, -), ADediting_1651623(24566663, -), ADediting_1651624(24572203, -), ADediting_1651625(24572208, -), ADediting_1651626(24572249, -), ADediting_1651627(24572263, -), ADediting_1651628(24572267, -), ADediting_1651629(24572273, -), ADediting_1651630(24572283, -), ADediting_1651631(24572408, -), |
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RNA editing positional annotations for DHX15 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1125586 | chr4_24525919_- | intergenic |
| ADediting_1125587 | chr4_24530343_- | intronic |
| ADediting_1125588 | chr4_24530465_- | intronic |
| ADediting_1125589 | chr4_24530490_- | intronic |
| ADediting_1125590 | chr4_24530495_- | intronic |
| ADediting_1125591 | chr4_24530525_- | intronic |
| ADediting_1125592 | chr4_24530576_- | intronic |
| ADediting_1125593 | chr4_24531186_- | intronic |
| ADediting_1125594 | chr4_24531221_- | intronic |
| ADediting_1125595 | chr4_24531227_- | intronic |
| ADediting_1125596 | chr4_24531253_- | intronic |
| ADediting_1125597 | chr4_24531291_- | intronic |
| ADediting_1125598 | chr4_24531316_- | intronic |
| ADediting_1125599 | chr4_24531355_- | intronic |
| ADediting_1125600 | chr4_24531360_- | intronic |
| ADediting_1125601 | chr4_24531361_- | intronic |
| ADediting_1125602 | chr4_24531456_- | intronic |
| ADediting_1125603 | chr4_24531461_- | intronic |
| ADediting_1125604 | chr4_24531468_- | intronic |
| ADediting_1125605 | chr4_24531469_- | intronic |
| ADediting_1125606 | chr4_24531541_- | intronic |
| ADediting_1125607 | chr4_24531594_- | intronic |
| ADediting_1125608 | chr4_24531596_- | intronic |
| ADediting_1125609 | chr4_24531623_- | intronic |
| ADediting_1125610 | chr4_24531650_- | intronic |
| ADediting_1125611 | chr4_24531669_- | intronic |
| ADediting_1125612 | chr4_24531672_- | intronic |
| ADediting_1125613 | chr4_24531699_- | intronic |
| ADediting_1125614 | chr4_24531706_- | intronic |
| ADediting_1125615 | chr4_24531707_- | intronic |
| ADediting_1125617 | chr4_24547700_- | intronic |
| ADediting_1125618 | chr4_24548294_- | intronic |
| ADediting_1125619 | chr4_24548410_- | intronic |
| ADediting_1125620 | chr4_24548415_- | intronic |
| ADediting_1125621 | chr4_24548416_- | intronic |
| ADediting_1125622 | chr4_24566135_- | intronic |
| ADediting_1125623 | chr4_24566136_- | intronic |
| ADediting_1125624 | chr4_24566146_- | intronic |
| ADediting_1125625 | chr4_24566154_- | intronic |
| ADediting_1125626 | chr4_24566178_- | intronic |
| ADediting_1125627 | chr4_24566200_- | intronic |
| ADediting_1125628 | chr4_24566302_- | intronic |
| ADediting_1125629 | chr4_24566309_- | intronic |
| ADediting_1125630 | chr4_24566315_- | intronic |
| ADediting_1125631 | chr4_24566581_- | intronic |
| ADediting_1125632 | chr4_24566591_- | intronic |
| ADediting_1125633 | chr4_24566596_- | intronic |
| ADediting_1125634 | chr4_24566608_- | intronic |
| ADediting_1125635 | chr4_24566621_- | intronic |
| ADediting_1125636 | chr4_24566622_- | intronic |
| ADediting_1125637 | chr4_24566623_- | intronic |
| ADediting_1125638 | chr4_24566682_- | intronic |
| ADediting_1125639 | chr4_24572219_- | intronic |
| ADediting_1125640 | chr4_24572409_- | intronic |
| ADediting_1125641 | chr4_24572411_- | intronic |
| ADediting_1125642 | chr4_24580324_- | intronic |
| ADediting_1577126 | chr4_24530405_- | intronic |
| ADediting_1577127 | chr4_24530415_- | intronic |
| ADediting_1577128 | chr4_24531002_- | intronic |
| ADediting_1577129 | chr4_24531283_- | intronic |
| ADediting_1577130 | chr4_24531293_- | intronic |
| ADediting_1577131 | chr4_24531494_- | intronic |
| ADediting_1577132 | chr4_24531515_- | intronic |
| ADediting_1577133 | chr4_24531530_- | intronic |
| ADediting_1651621 | chr4_24530468_- | intronic |
| ADediting_1651622 | chr4_24566282_- | intronic |
| ADediting_1651623 | chr4_24566663_- | intronic |
| ADediting_1651624 | chr4_24572203_- | intronic |
| ADediting_1651625 | chr4_24572208_- | intronic |
| ADediting_1651626 | chr4_24572249_- | intronic |
| ADediting_1651627 | chr4_24572263_- | intronic |
| ADediting_1651628 | chr4_24572267_- | intronic |
| ADediting_1651629 | chr4_24572273_- | intronic |
| ADediting_1651630 | chr4_24572283_- | intronic |
| ADediting_1651631 | chr4_24572408_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1125586 | chr4_24525919_- | SINE | Alu | Name=AluY |
| ADediting_1125587 | chr4_24530343_- | SINE | Alu | Name=AluSx1 |
| ADediting_1125588 | chr4_24530465_- | SINE | Alu | Name=AluSx1 |
| ADediting_1125589 | chr4_24530490_- | SINE | Alu | Name=AluSx1 |
| ADediting_1125590 | chr4_24530495_- | SINE | Alu | Name=AluSx1 |
| ADediting_1125591 | chr4_24530525_- | SINE | Alu | Name=AluSx1 |
| ADediting_1125592 | chr4_24530576_- | SINE | Alu | Name=AluSx1 |
| ADediting_1125593 | chr4_24531186_- | SINE | Alu | Name=AluYk3 |
| ADediting_1125594 | chr4_24531221_- | SINE | Alu | Name=AluYk3 |
| ADediting_1125595 | chr4_24531227_- | SINE | Alu | Name=AluYk3 |
| ADediting_1125596 | chr4_24531253_- | SINE | Alu | Name=AluYk3 |
| ADediting_1125597 | chr4_24531291_- | SINE | Alu | Name=AluYk3 |
| ADediting_1125598 | chr4_24531316_- | SINE | Alu | Name=AluYk3 |
| ADediting_1125599 | chr4_24531355_- | SINE | Alu | Name=AluYk3 |
| ADediting_1125600 | chr4_24531360_- | SINE | Alu | Name=AluYk3 |
| ADediting_1125601 | chr4_24531361_- | SINE | Alu | Name=AluYk3 |
| ADediting_1125602 | chr4_24531456_- | SINE | Alu | Name=AluJb |
| ADediting_1125603 | chr4_24531461_- | SINE | Alu | Name=AluJb |
| ADediting_1125604 | chr4_24531468_- | SINE | Alu | Name=AluJb |
| ADediting_1125605 | chr4_24531469_- | SINE | Alu | Name=AluJb |
| ADediting_1125606 | chr4_24531541_- | SINE | Alu | Name=AluJb |
| ADediting_1125607 | chr4_24531594_- | SINE | Alu | Name=AluJb |
| ADediting_1125608 | chr4_24531596_- | SINE | Alu | Name=AluJb |
| ADediting_1125609 | chr4_24531623_- | SINE | Alu | Name=AluJb |
| ADediting_1125610 | chr4_24531650_- | SINE | Alu | Name=AluJb |
| ADediting_1125611 | chr4_24531669_- | SINE | Alu | Name=AluJb |
| ADediting_1125612 | chr4_24531672_- | SINE | Alu | Name=AluJb |
| ADediting_1125613 | chr4_24531699_- | SINE | Alu | Name=AluJb |
| ADediting_1125614 | chr4_24531706_- | SINE | Alu | Name=AluJb |
| ADediting_1125615 | chr4_24531707_- | SINE | Alu | Name=AluJb |
| ADediting_1125617 | chr4_24547700_- | SINE | Alu | Name=FLAM_C |
| ADediting_1125618 | chr4_24548294_- | SINE | Alu | Name=AluSx3 |
| ADediting_1125619 | chr4_24548410_- | SINE | Alu | Name=AluSx3 |
| ADediting_1125620 | chr4_24548415_- | SINE | Alu | Name=AluSx3 |
| ADediting_1125621 | chr4_24548416_- | SINE | Alu | Name=AluSx3 |
| ADediting_1125622 | chr4_24566135_- | SINE | Alu | Name=AluJr |
| ADediting_1125623 | chr4_24566136_- | SINE | Alu | Name=AluJr |
| ADediting_1125624 | chr4_24566146_- | SINE | Alu | Name=AluJr |
| ADediting_1125625 | chr4_24566154_- | SINE | Alu | Name=AluJr |
| ADediting_1125626 | chr4_24566178_- | SINE | Alu | Name=AluJr |
| ADediting_1125627 | chr4_24566200_- | SINE | Alu | Name=AluJr |
| ADediting_1125628 | chr4_24566302_- | SINE | Alu | Name=AluJr |
| ADediting_1125629 | chr4_24566309_- | SINE | Alu | Name=AluJr |
| ADediting_1125630 | chr4_24566315_- | SINE | Alu | Name=AluJr |
| ADediting_1125631 | chr4_24566581_- | SINE | Alu | Name=AluSz |
| ADediting_1125632 | chr4_24566591_- | SINE | Alu | Name=AluSz |
| ADediting_1125633 | chr4_24566596_- | SINE | Alu | Name=AluSz |
| ADediting_1125634 | chr4_24566608_- | SINE | Alu | Name=AluSz |
| ADediting_1125635 | chr4_24566621_- | SINE | Alu | Name=AluSz |
| ADediting_1125636 | chr4_24566622_- | SINE | Alu | Name=AluSz |
| ADediting_1125637 | chr4_24566623_- | SINE | Alu | Name=AluSz |
| ADediting_1125638 | chr4_24566682_- | SINE | Alu | Name=AluSz |
| ADediting_1125639 | chr4_24572219_- | SINE | Alu | Name=AluSx3 |
| ADediting_1125640 | chr4_24572409_- | SINE | Alu | Name=AluSx3 |
| ADediting_1125641 | chr4_24572411_- | SINE | Alu | Name=AluSx3 |
| ADediting_1125642 | chr4_24580324_- | SINE | Alu | Name=AluJr |
| ADediting_1577126 | chr4_24530405_- | SINE | Alu | Name=AluSx1 |
| ADediting_1577127 | chr4_24530415_- | SINE | Alu | Name=AluSx1 |
| ADediting_1577129 | chr4_24531283_- | SINE | Alu | Name=AluYk3 |
| ADediting_1577130 | chr4_24531293_- | SINE | Alu | Name=AluYk3 |
| ADediting_1577131 | chr4_24531494_- | SINE | Alu | Name=AluJb |
| ADediting_1577132 | chr4_24531515_- | SINE | Alu | Name=AluJb |
| ADediting_1577133 | chr4_24531530_- | SINE | Alu | Name=AluJb |
| ADediting_1651621 | chr4_24530468_- | SINE | Alu | Name=AluSx1 |
| ADediting_1651622 | chr4_24566282_- | SINE | Alu | Name=AluJr |
| ADediting_1651623 | chr4_24566663_- | SINE | Alu | Name=AluSz |
| ADediting_1651624 | chr4_24572203_- | SINE | Alu | Name=AluSx3 |
| ADediting_1651625 | chr4_24572208_- | SINE | Alu | Name=AluSx3 |
| ADediting_1651626 | chr4_24572249_- | SINE | Alu | Name=AluSx3 |
| ADediting_1651627 | chr4_24572263_- | SINE | Alu | Name=AluSx3 |
| ADediting_1651628 | chr4_24572267_- | SINE | Alu | Name=AluSx3 |
| ADediting_1651629 | chr4_24572273_- | SINE | Alu | Name=AluSx3 |
| ADediting_1651630 | chr4_24572283_- | SINE | Alu | Name=AluSx3 |
| ADediting_1651631 | chr4_24572408_- | SINE | Alu | Name=AluSx3 |
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RNA A-to-I editing events in the alternative splicing sites for DHX15 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for DHX15 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for DHX15 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for DHX15 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1125587 | chr4_24530343_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-6089 | chr4 | 24530338 | 24530344 | 7mer-m8 | 24530337 | 24530359 | 164 | -37.77 |
| ADediting_1125588 | chr4_24530465_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-4691-3p | chr4 | 24530461 | 24530467 | 7mer-m8 | 24530460 | 24530487 | 150 | -26.36 |
| ADediting_1125589 | chr4_24530490_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-146a-5p | chr4 | 24530485 | 24530491 | 7mer-m8 | 24530484 | 24530508 | 151 | -20.69 |
| ADediting_1125589 | chr4_24530490_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-146b-5p | chr4 | 24530485 | 24530491 | 7mer-m8 | 24530484 | 24530510 | 152 | -22.2 |
| ADediting_1125589 | chr4_24530490_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-7153-5p | chr4 | 24530485 | 24530491 | 7mer-m8 | 24530484 | 24530507 | 152 | -18.25 |
| ADediting_1125591 | chr4_24530525_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-4537 | chr4 | 24530520 | 24530527 | 8mer-1a | 24530520 | 24530541 | 158 | -23.93 |
| ADediting_1125592 | chr4_24530576_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-371b-5p | chr4 | 24530575 | 24530582 | 8mer-1a | 24530575 | 24530596 | 146 | -9.2 |
| ADediting_1125592 | chr4_24530576_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-373-5p | chr4 | 24530575 | 24530582 | 8mer-1a | 24530575 | 24530596 | 146 | -9.66 |
| ADediting_1125592 | chr4_24530576_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-616-5p | chr4 | 24530575 | 24530582 | 8mer-1a | 24530575 | 24530596 | 140 | -6.3 |
| ADediting_1577126 | chr4_24530405_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-6771-3p | chr4 | 24530400 | 24530406 | 7mer-m8 | 24530399 | 24530420 | 158 | -18.1 |
| ADediting_1651621 | chr4_24530468_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-6840-3p | chr4 | 24530467 | 24530473 | 7mer-m8 | 24530466 | 24530488 | 155 | -26.67 |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1125587 | chr4_24530343_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-4329 | chr4 | 24530342 | 24530348 | 7mer-m8 | 24530341 | 24530360 | 143 | -15.54 |
| ADediting_1125587 | chr4_24530343_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-4478 | chr4 | 24530339 | 24530345 | 7mer-m8 | 24530338 | 24530353 | 149 | -22.29 |
| ADediting_1125587 | chr4_24530343_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-485-5p | chr4 | 24530338 | 24530344 | 7mer-m8 | 24530337 | 24530359 | 145 | -15.52 |
| ADediting_1125588 | chr4_24530465_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-5690 | chr4 | 24530461 | 24530467 | 7mer-m8 | 24530460 | 24530480 | 145 | -17.72 |
| ADediting_1125589 | chr4_24530490_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-219b-3p | chr4 | 24530487 | 24530493 | 7mer-m8 | 24530486 | 24530506 | 149 | -18.92 |
| ADediting_1125591 | chr4_24530525_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-3160-3p | chr4 | 24530520 | 24530527 | 8mer-1a | 24530520 | 24530541 | 154 | -17.04 |
| ADediting_1577126 | chr4_24530405_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-6072 | chr4 | 24530403 | 24530409 | 7mer-m8 | 24530402 | 24530424 | 151 | -15.66 |
| ADediting_1577126 | chr4_24530405_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-6891-3p | chr4 | 24530403 | 24530409 | 7mer-m8 | 24530402 | 24530422 | 146 | -12.88 |
| ADediting_1651621 | chr4_24530468_- | ENSG00000109606.13 | ENST00000513036.5 | DHX15-209 | hsa-miR-3664-3p | chr4 | 24530467 | 24530473 | 7mer-m8 | 24530466 | 24530489 | 154 | -20.99 |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1556067 | chr19_40282625_- | ENSG00000109606.13 | ENST00000336812.5 | DHX15-201 | hsa-miR-641 | chr4 | 24527515 | 24527521 | 7mer-1a | 24527515 | 24527539 | 144 | -17 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for DHX15 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000513036.5 | lncRNA |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1125587 | ENST00000513036.5 | chr4_24530343_- | 541 | -488.30 | -486.20 | -496.30 |
| ADediting_1577126 | ENST00000513036.5 | chr4_24530405_- | 479 | -488.00 | -486.20 | -496.30 |
| ADediting_1577127 | ENST00000513036.5 | chr4_24530415_- | 469 | -489.10 | -486.20 | -496.30 |
| ADediting_1125588 | ENST00000513036.5 | chr4_24530465_- | 419 | -487.40 | -486.20 | -496.30 |
| ADediting_1651621 | ENST00000513036.5 | chr4_24530468_- | 416 | -487.70 | -486.20 | -496.30 |
| ADediting_1125589 | ENST00000513036.5 | chr4_24530490_- | 394 | -486.20 | -486.20 | -496.30 |
| ADediting_1125590 | ENST00000513036.5 | chr4_24530495_- | 389 | -485.50 | -486.20 | -496.30 |
| ADediting_1125591 | ENST00000513036.5 | chr4_24530525_- | 359 | -485.40 | -486.20 | -496.30 |
| ADediting_1125592 | ENST00000513036.5 | chr4_24530576_- | 308 | -486.70 | -486.20 | -496.30 |
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Relation with ADAR for DHX15 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_1125591 | chr4_24530525_- | 0.00015909389236376 | 0.212882980738734 | 0.00850719170101487 | 0.149210129996999 | 6.49527899935688e-08 | 0.30102756815457 |
| CER | ADediting_1125603 | chr4_24531461_- | 0.000169091431722174 | 0.302409228863259 | 6.38284576580618e-06 | 0.359142671879329 | 0.0159163545812578 | 0.196563296820798 |
| CER | ADediting_1125604 | chr4_24531468_- | 7.72475359263566e-06 | 0.356125693686824 | 0.000115893041241125 | 0.309554483755 | 0.972275025572048 | -0.00286167540080081 |
| DLPFC | ADediting_1125606 | chr4_24531541_- | 0.129282938467496 | 0.0863439892563091 | 0.619029545210141 | -0.0283493984591777 | 2.27587237805213e-13 | 0.400463721566697 |
| CER | ADediting_1125606 | chr4_24531541_- | 1.82790113804965e-06 | 0.378191834419605 | 5.57106631136379e-06 | 0.361274814681047 | 0.149057786830038 | 0.118385281967452 |
| CER | ADediting_1125608 | chr4_24531596_- | 1.27998032704183e-12 | 0.53778801675895 | 8.84502674008056e-12 | 0.520303601632602 | 0.00655394030667712 | 0.221076601940854 |
| DLPFC | ADediting_1125611 | chr4_24531669_- | 0.693343343389511 | 0.0224839813496429 | 0.373358139663668 | -0.0507323820734662 | 6.62334338349947e-09 | 0.321919452565295 |
| DLPFC | ADediting_1125620 | chr4_24548415_- | 0.194413935267336 | -0.0738982507163012 | 0.00636979209303699 | -0.154637965061798 | 3.81588383281804e-08 | 0.306042174845417 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 7.53957850509467e-45 | 0.688319101353348 | 1.76230238499714e-36 | 0.635567534186509 | 0.000547607575434497 | 0.19520253990636 |
| AC | 1.35210718416733e-73 | 0.857670528728703 | 4.7650002867946e-48 | 0.758626242726843 | 3.69684149473885e-16 | 0.485049205812873 |
| PCC | 1.41150344997325e-23 | 0.641971666569398 | 4.86633764924888e-27 | 0.677780741429245 | 0.0109026924348844 | 0.183841806435718 |
| CER | 1.08129017636115e-35 | 0.807133051578684 | 2.98986533673552e-36 | 0.81083009297517 | 0.00428549012874506 | 0.231970243477889 |
| TCX | 4.55493283645607e-34 | 0.795902404589913 | 3.86774786239163e-09 | 0.457775864906349 | 1.2851612523745e-09 | 0.470081679041918 |
| FP | 4.23161580861431e-17 | 0.575699566128276 | 8.66373809433539e-29 | 0.711647487433976 | 0.189147575919323 | 0.0988766334560879 |
| IFG | 4.76867093128317e-09 | 0.883790846334801 | 2.06547383234225e-06 | 0.794920982439489 | 0.0223920654448855 | 0.454704100781262 |
| PG | 1.45237341007217e-50 | 0.839227289452087 | 2.18926418944817e-28 | 0.697058965590363 | 0.899704659894213 | 0.00930381369598093 |
| STG | 2.20773627312796e-16 | 0.750014065516567 | 6.51566589096195e-16 | 0.742245894894081 | 0.620259077308438 | 0.0548426890077286 |
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Relation with AD stages for DHX15 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_1125608 | chr4_24531596_- | 0.00046492250294944 | 0.331106509962992 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 3.89550938342155e-08 | 0.498907354552527 |
| TCX | 1.8764080747696e-06 | 0.443911280366206 |
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RelatedDrugs for DHX15 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DHX15 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| DHX15 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| DHX15 | C0026998 | Acute Myeloid Leukemia, M1 | 1 | CTD_human |
| DHX15 | C1879321 | Acute Myeloid Leukemia (AML-M2) | 1 | CTD_human |
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