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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for LGI4

check button Gene summary
Gene informationGene symbol

LGI4

Gene ID

163175

Gene nameleucine rich repeat LGI family member 4
SynonymsAMCNMY|LGIL3
Cytomap

19q13.12|19q13.11

Type of geneprotein-coding
Descriptionleucine-rich repeat LGI family member 4LGI1-like protein 3leucine-rich glioma-inactivated gene 4leucine-rich glioma-inactivated protein 4
Modification date20200320
UniProtAcc

Q8N135,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for LGI4

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_739976(35127277, -), ADediting_739977(35127333, -), ADediting_739978(35127404, -), ADediting_739979(35127539, -), ADediting_739980(35127658, -), ADediting_739981(35127659, -), ADediting_739982(35127667, -), ADediting_739983(35128463, -), ADediting_739984(35128635, -), ADediting_739985(35130455, -), ADediting_739986(35130519, -), ADediting_739987(35130658, -), ADediting_739988(35135504, -), ADediting_739989(35136238, -), ADediting_739990(35136362, -), ADediting_739991(35136424, -), ADediting_739992(35136451, -), ADediting_739993(35136804, -), ADediting_739994(35136806, -), ADediting_739995(35136816, -), ADediting_739996(35136817, -), ADediting_739997(35136827, -), ADediting_739998(35136832, -), ADediting_739999(35136840, -), ADediting_740000(35136844, -), ADediting_740001(35136845, -), ADediting_740002(35136870, -), ADediting_740003(35136940, -), ADediting_740004(35136950, -), ADediting_740005(35136962, -), ADediting_740006(35136967, -), ADediting_740007(35136979, -), ADediting_740008(35136980, -), ADediting_740009(35136988, -), ADediting_740010(35136993, -), ADediting_740011(35137005, -), ADediting_740012(35137016, -), ADediting_740013(35137023, -), ADediting_740014(35137030, -), ADediting_740015(35137036, -), ADediting_740016(35137040, -), ADediting_740017(35137060, -), ADediting_740018(35137434, -), ADediting_740019(35137662, -), ADediting_740020(35137664, -), ADediting_740021(35137665, -), ADediting_740022(35137689, -), ADediting_740023(35137694, -), ADediting_740024(35137712, -), ADediting_740025(35137724, -), ADediting_740026(35137729, -), ADediting_740027(35137738, -), ADediting_740028(35137742, -), ADediting_740029(35137748, -), ADediting_740030(35137755, -), ADediting_740031(35137764, -), ADediting_740032(35137791, -), ADediting_740033(35137794, -), ADediting_740034(35137795, -), ADediting_740035(35137809, -), ADediting_740036(35137855, -), ADediting_740037(35137863, -), ADediting_740038(35137868, -), ADediting_740039(35137881, -), ADediting_740040(35137882, -), ADediting_740041(35137887, -), ADediting_740042(35137977, -), ADediting_740043(35137993, -), ADediting_740044(35138606, -), ADediting_740045(35138635, -), ADediting_740046(35138745, -), ADediting_1555229(35127300, -), ADediting_1555230(35127380, -), ADediting_1555231(35127408, -), ADediting_1555232(35127427, -), ADediting_1555233(35127431, -), ADediting_1555234(35127432, -), ADediting_1555235(35130575, -), ADediting_1555236(35130645, -), ADediting_1555237(35137716, -), ADediting_1555238(35137805, -),

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RNA editing positional annotations for LGI4 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_739976chr19_35127277_-intronic
ADediting_739977chr19_35127333_-intronic
ADediting_739978chr19_35127404_-intronic
ADediting_739979chr19_35127539_-intronic
ADediting_739980chr19_35127658_-intronic
ADediting_739981chr19_35127659_-intronic
ADediting_739982chr19_35127667_-intronic
ADediting_739983chr19_35128463_-intronic
ADediting_739984chr19_35128635_-intronic
ADediting_739985chr19_35130455_-intronic
ADediting_739986chr19_35130519_-intronic
ADediting_739987chr19_35130658_-intronic
ADediting_739988chr19_35135504_-upstream
ADediting_739989chr19_35136238_-intergenic
ADediting_739990chr19_35136362_-intergenic
ADediting_739991chr19_35136424_-intergenic
ADediting_739992chr19_35136451_-intergenic
ADediting_739993chr19_35136804_-downstream
ADediting_739994chr19_35136806_-downstream
ADediting_739995chr19_35136816_-downstream
ADediting_739996chr19_35136817_-downstream
ADediting_739997chr19_35136827_-downstream
ADediting_739998chr19_35136832_-downstream
ADediting_739999chr19_35136840_-downstream
ADediting_740000chr19_35136844_-downstream
ADediting_740001chr19_35136845_-downstream
ADediting_740002chr19_35136870_-downstream
ADediting_740003chr19_35136940_-downstream
ADediting_740004chr19_35136950_-downstream
ADediting_740005chr19_35136962_-downstream
ADediting_740006chr19_35136967_-downstream
ADediting_740007chr19_35136979_-downstream
ADediting_740008chr19_35136980_-downstream
ADediting_740009chr19_35136988_-downstream
ADediting_740010chr19_35136993_-downstream
ADediting_740011chr19_35137005_-downstream
ADediting_740012chr19_35137016_-downstream
ADediting_740013chr19_35137023_-downstream
ADediting_740014chr19_35137030_-downstream
ADediting_740015chr19_35137036_-downstream
ADediting_740016chr19_35137040_-downstream
ADediting_740017chr19_35137060_-downstream
ADediting_740018chr19_35137434_-downstream
ADediting_740019chr19_35137662_-ncRNA_exonic
ADediting_740020chr19_35137664_-ncRNA_exonic
ADediting_740021chr19_35137665_-ncRNA_exonic
ADediting_740022chr19_35137689_-ncRNA_exonic
ADediting_740023chr19_35137694_-ncRNA_exonic
ADediting_740024chr19_35137712_-ncRNA_exonic
ADediting_740025chr19_35137724_-ncRNA_exonic
ADediting_740026chr19_35137729_-ncRNA_exonic
ADediting_740027chr19_35137738_-ncRNA_exonic
ADediting_740028chr19_35137742_-ncRNA_exonic
ADediting_740029chr19_35137748_-ncRNA_exonic
ADediting_740030chr19_35137755_-ncRNA_exonic
ADediting_740031chr19_35137764_-ncRNA_exonic
ADediting_740032chr19_35137791_-ncRNA_exonic
ADediting_740033chr19_35137794_-ncRNA_exonic
ADediting_740034chr19_35137795_-ncRNA_exonic
ADediting_740035chr19_35137809_-ncRNA_exonic
ADediting_740036chr19_35137855_-ncRNA_exonic
ADediting_740037chr19_35137863_-ncRNA_exonic
ADediting_740038chr19_35137868_-ncRNA_exonic
ADediting_740039chr19_35137881_-ncRNA_exonic
ADediting_740040chr19_35137882_-ncRNA_exonic
ADediting_740041chr19_35137887_-ncRNA_exonic
ADediting_740042chr19_35137977_-ncRNA_exonic
ADediting_740043chr19_35137993_-ncRNA_exonic
ADediting_740044chr19_35138606_-ncRNA_exonic
ADediting_740045chr19_35138635_-ncRNA_exonic
ADediting_740046chr19_35138745_-ncRNA_exonic
ADediting_1555229chr19_35127300_-intronic
ADediting_1555230chr19_35127380_-intronic
ADediting_1555231chr19_35127408_-intronic
ADediting_1555232chr19_35127427_-intronic
ADediting_1555233chr19_35127431_-intronic
ADediting_1555234chr19_35127432_-intronic
ADediting_1555235chr19_35130575_-intronic
ADediting_1555236chr19_35130645_-intronic
ADediting_1555237chr19_35137716_-ncRNA_exonic
ADediting_1555238chr19_35137805_-ncRNA_exonic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_739976chr19_35127277_-SINEAluName=AluJo
ADediting_739977chr19_35127333_-SINEAluName=AluJo
ADediting_739978chr19_35127404_-SINEAluName=AluJo
ADediting_739979chr19_35127539_-SINEAluName=AluSx1
ADediting_739980chr19_35127658_-SINEAluName=AluSx1
ADediting_739981chr19_35127659_-SINEAluName=AluSx1
ADediting_739982chr19_35127667_-SINEAluName=AluSx1
ADediting_739983chr19_35128463_-SINEAluName=AluJb
ADediting_739984chr19_35128635_-SINEAluName=AluJb
ADediting_739985chr19_35130455_-SINEAluName=AluJr
ADediting_739986chr19_35130519_-SINEAluName=AluJr
ADediting_739987chr19_35130658_-SINEAluName=AluJr
ADediting_739990chr19_35136362_-SINEMIRName=MIR
ADediting_739991chr19_35136424_-SINEMIRName=MIR
ADediting_739992chr19_35136451_-SINEMIRName=MIR
ADediting_739993chr19_35136804_-SINEAluName=AluJr
ADediting_739994chr19_35136806_-SINEAluName=AluJr
ADediting_739995chr19_35136816_-SINEAluName=AluJr
ADediting_739996chr19_35136817_-SINEAluName=AluJr
ADediting_739997chr19_35136827_-SINEAluName=AluJr
ADediting_739998chr19_35136832_-SINEAluName=AluJr
ADediting_739999chr19_35136840_-SINEAluName=AluJr
ADediting_740000chr19_35136844_-SINEAluName=AluJr
ADediting_740001chr19_35136845_-SINEAluName=AluJr
ADediting_740002chr19_35136870_-SINEAluName=AluJr
ADediting_740003chr19_35136940_-SINEAluName=AluJr
ADediting_740004chr19_35136950_-SINEAluName=AluJr
ADediting_740005chr19_35136962_-SINEAluName=AluJr
ADediting_740006chr19_35136967_-SINEAluName=AluJr
ADediting_740007chr19_35136979_-SINEAluName=AluJr
ADediting_740008chr19_35136980_-SINEAluName=AluJr
ADediting_740009chr19_35136988_-SINEAluName=AluJr
ADediting_740010chr19_35136993_-SINEAluName=AluJr
ADediting_740011chr19_35137005_-SINEAluName=AluJr
ADediting_740012chr19_35137016_-SINEAluName=AluJr
ADediting_740013chr19_35137023_-SINEAluName=AluJr
ADediting_740014chr19_35137030_-SINEAluName=AluJr
ADediting_740015chr19_35137036_-SINEAluName=AluJr
ADediting_740016chr19_35137040_-SINEAluName=AluJr
ADediting_740017chr19_35137060_-SINEAluName=AluJr
ADediting_740019chr19_35137662_-SINEAluName=AluSz6
ADediting_740020chr19_35137664_-SINEAluName=AluSz6
ADediting_740021chr19_35137665_-SINEAluName=AluSz6
ADediting_740022chr19_35137689_-SINEAluName=AluSz6
ADediting_740023chr19_35137694_-SINEAluName=AluSz6
ADediting_740024chr19_35137712_-SINEAluName=AluSz6
ADediting_740025chr19_35137724_-SINEAluName=AluSz6
ADediting_740026chr19_35137729_-SINEAluName=AluSz6
ADediting_740027chr19_35137738_-SINEAluName=AluSz6
ADediting_740028chr19_35137742_-SINEAluName=AluSz6
ADediting_740029chr19_35137748_-SINEAluName=AluSz6
ADediting_740030chr19_35137755_-SINEAluName=AluSz6
ADediting_740031chr19_35137764_-SINEAluName=AluSz6
ADediting_740032chr19_35137791_-SINEAluName=AluSz6
ADediting_740033chr19_35137794_-SINEAluName=AluSz6
ADediting_740034chr19_35137795_-SINEAluName=AluSz6
ADediting_740035chr19_35137809_-SINEAluName=AluSz6
ADediting_740036chr19_35137855_-SINEAluName=AluSz6
ADediting_740037chr19_35137863_-SINEAluName=AluSz6
ADediting_740038chr19_35137868_-SINEAluName=AluSz6
ADediting_740039chr19_35137881_-SINEAluName=AluSz6
ADediting_740040chr19_35137882_-SINEAluName=AluSz6
ADediting_740041chr19_35137887_-SINEAluName=AluSz6
ADediting_1555229chr19_35127300_-SINEAluName=AluJo
ADediting_1555230chr19_35127380_-SINEAluName=AluJo
ADediting_1555231chr19_35127408_-SINEAluName=AluJo
ADediting_1555232chr19_35127427_-SINEAluName=AluJo
ADediting_1555233chr19_35127431_-SINEAluName=AluJo
ADediting_1555234chr19_35127432_-SINEAluName=AluJo
ADediting_1555235chr19_35130575_-SINEAluName=AluJr
ADediting_1555236chr19_35130645_-SINEAluName=AluJr
ADediting_1555237chr19_35137716_-SINEAluName=AluSz6
ADediting_1555238chr19_35137805_-SINEAluName=AluSz6

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RNA A-to-I editing events in the alternative splicing sites for LGI4

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for LGI4

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for LGI4

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for LGI4


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337758chr7_5495892_-ENSG00000153902.14ENST00000310123.8LGI4-201hsa-miR-589-5pchr1935124697351247037mer-m83512469635124717157-27.56
ADediting_1337758chr7_5495892_-ENSG00000153902.14ENST00000392225.7LGI4-202hsa-miR-589-5pchr1935124697351247037mer-m83512469635124717157-27.56
ADediting_1337758chr7_5495892_-ENSG00000153902.14ENST00000587780.5LGI4-205hsa-miR-589-5pchr1935124697351247037mer-m83512469635124717157-27.56

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_107020chr1_37500952_-ENSG00000153902.14ENST00000310123.8LGI4-201hsa-miR-5581-3pchr1935124890351248967mer-m83512488935124910140-15.99
ADediting_107020chr1_37500952_-ENSG00000153902.14ENST00000392225.7LGI4-202hsa-miR-5581-3pchr1935124890351248967mer-m83512488935124910140-15.99
ADediting_107020chr1_37500952_-ENSG00000153902.14ENST00000587780.5LGI4-205hsa-miR-5581-3pchr1935124890351248967mer-m83512488935124910140-15.99
ADediting_1535951chr14_100874558_+ENSG00000153902.14ENST00000591633.2LGI4-206hsa-miR-337-3pchr1935131200351312067mer-m83513119935131219152-15.15
ADediting_496066chr15_66496985_-ENSG00000153902.14ENST00000587780.5LGI4-205hsa-miR-4512chr1935125528351255347mer-m83512552735125548140-16.95

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for LGI4

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for LGI4

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_739989chr19_35136238_-4.80806412079512e-140.4106987544376997.35348094804973e-180.4627981928813120.8244368378019630.0126503824837429
TCXADediting_739989chr19_35136238_-3.60373890487655e-070.4012581720571496.04749812065809e-070.3940927647254630.124887125687016-0.125851982021745
DLPFCADediting_739990chr19_35136362_-7.49840103229218e-090.3208244435352311.92401575304564e-100.3514554662223510.723332607188875-0.020185821525303
TCXADediting_739990chr19_35136362_-3.60321416204157e-050.3305716901300947.07715952024482e-090.4508147720561720.000320381533551261-0.289885645937571
DLPFCADediting_739992chr19_35136451_-3.61193340712097e-080.3065546883075553.10207100245026e-090.3285196450819270.717765091384541-0.0206099056237442
DLPFCADediting_739993chr19_35136804_-1.9750860427063e-100.3512478282849673.85625924773217e-090.3266421402561040.03189898736641250.121903713351385
TCXADediting_739993chr19_35136804_-0.0005169727046549720.2801181334209075.41231329415894e-060.3617259933907160.184513979801809-0.108936349633468
DLPFCADediting_739994chr19_35136806_-9.90214323721131e-110.3566703404906725.44522456524123e-110.3612853054718580.1135600669891770.0900549383471072
TCXADediting_739994chr19_35136806_-1.11753962610813e-050.3501980319233942.27495777755452e-080.436902713954030.046230462037453-0.163024186198534
DLPFCADediting_739995chr19_35136816_-1.0195369733772e-110.3738348742529875.60820734740462e-110.3610594391232890.0001368421661843870.214940932065087
TCXADediting_739995chr19_35136816_-1.17483722451107e-070.4162205384893663.01235943894464e-110.5086787726419960.153090130719732-0.117231021716292
DLPFCADediting_739996chr19_35136817_-4.98962226220545e-110.3619534600374432.5384252107643e-100.3492512501087540.01186385829904060.142752797150921
TCXADediting_739996chr19_35136817_-1.02837764269449e-060.3865644978199844.91476880577813e-090.4550343456167990.208950376382216-0.103178368931058
DLPFCADediting_739997chr19_35136827_-2.53050223063167e-110.3670930206025799.22687911346301e-110.3572192894659150.002564548861282540.170706402878632
TCXADediting_739997chr19_35136827_-1.03312978759317e-060.3864983001799982.51911194445844e-090.4626228167868210.355063011170159-0.0760373924998673
TCXADediting_739998chr19_35136832_-0.003673614544503340.2358032609105792.13241955284244e-050.3395298326419780.361957048069536-0.0749575521552541
DLPFCADediting_740000chr19_35136844_-1.21495225424703e-110.3725465087691465.46840749699793e-110.3612527795748130.4507696669313670.0429856976251578
TCXADediting_740000chr19_35136844_-5.10071113623576e-050.3244794494561711.18701525156944e-060.3844978363806510.451627768293602-0.061916993462536
TCXADediting_740003chr19_35136940_-9.35672299752221e-060.3530640004855441.7597998382143e-060.3787517317979720.9099962711130470.00930760497198215
TCXADediting_740004chr19_35136950_-9.4482862264293e-050.3133431146465281.30895909522702e-050.3476232802973250.9057835615024810.00974522985727849
DLPFCADediting_740012chr19_35137016_-2.53319615589043e-090.3302560103871877.48450437680504e-070.2766604229964710.0006906638773910370.191708000163953
DLPFCADediting_740013chr19_35137023_-5.95159725920768e-110.3606037646687577.37955441009913e-080.2998100050945180.0001162934292351160.217141738898235
DLPFCADediting_740015chr19_35137036_-4.91611691778664e-080.3036655020009062.03353203138637e-060.2659845927626710.05331001386159090.109864387122363
DLPFCADediting_740016chr19_35137040_-1.36687829989191e-120.3882069507315783.5308806047767e-090.3274041654026120.01127397238137220.143759045145607
TCXADediting_740016chr19_35137040_-0.000109600841477940.3105950205925586.39845161893774e-050.3204350498186520.549409094382140.0492616329633643
TCXADediting_740017chr19_35137060_-4.03589127740307e-050.3285980629259060.001020671204467210.2655883978810150.3389212174242590.0786182249719104
TCXADediting_740019chr19_35137662_-5.04128286856264e-050.3246870000075584.63381931643145e-060.3641379518419280.390770198827588-0.070576458417602
DLPFCADediting_740020chr19_35137664_-3.42512092706762e-080.3070492621348571.56324520723603e-060.2688383475226390.004243730079378040.161986445543997
TCXADediting_740020chr19_35137664_-1.20179162453617e-050.3490171520929723.89273828692939e-080.4302870245777610.269680446659831-0.0906976270274772
DLPFCADediting_740021chr19_35137665_-5.55684654547525e-080.3025085442071512.15148733059823e-050.2387674766952410.006609412658177870.153954515924658
TCXADediting_740021chr19_35137665_-3.60792771060306e-080.4312314340362671.34371150411125e-090.4695934278387160.442343527014149-0.0631925900646954
DLPFCADediting_740022chr19_35137689_-1.11161879187484e-080.3173208142688493.58370433287648e-050.2324433780016190.005580927147293170.15706349938181
TCXADediting_740022chr19_35137689_-8.64253291162115e-080.4201950385704544.07506107505863e-080.4297166803974360.956300942598289-0.00451179990840282
DLPFCADediting_740023chr19_35137694_-5.60469496270364e-080.3024273867119362.59239441337654e-050.2364769730577420.002604529396544150.17044457856724
TCXADediting_740023chr19_35137694_-1.70384405152023e-050.3432786646936894.87412907755346e-070.3970989144556590.410856410893249-0.0676365274591719
TCXADediting_740032chr19_35137791_-0.0005135648185501230.2802555845232616.34435964201862e-050.3205875661410340.250718755813342-0.0943631940385659
TCXADediting_740037chr19_35137863_-2.14583601135103e-050.33942434341231.32512899942903e-050.3474223886187970.834222845942118-0.0172312321666991
DLPFCADediting_740038chr19_35137868_-5.42489609063839e-080.302735891943639.05545215873967e-060.2491152752699960.02473227774234770.12753315712811
TCXADediting_740038chr19_35137868_-2.50327456391283e-050.3368209083518459.5820325430556e-050.3130840097966470.8777403397284680.0126659761669614
DLPFCADediting_740039chr19_35137881_-1.40834001082644e-090.3352272156431414.16420148668409e-070.2827185538709060.03560472907295260.119407281811294
TCXADediting_740039chr19_35137881_-8.75951135586406e-060.3541211615451968.70191884847403e-060.3542266867818950.915797416717053-0.00870539326829094
DLPFCADediting_740040chr19_35137882_-2.97330446129358e-090.3288839204831581.15325414594648e-070.2955063426684080.03628730955978730.11897175709043
DLPFCADediting_740041chr19_35137887_-6.41551484328624e-110.3600272031368831.43445980479477e-080.3150275197706870.05678104030785660.108315349577875
TCXADediting_740041chr19_35137887_-0.0001888052513400380.3002883902712322.81710107446545e-050.3348092113010270.475149989937662-0.0587491232558161
DLPFCADediting_740043chr19_35137993_-2.29169004823324e-090.3311107419514785.21047796689626e-090.3240243287010370.656254959484022-0.0253778424608151
TCXADediting_740043chr19_35137993_-2.22645831611506e-080.4371651951923071.74423298750594e-080.4401229933296840.776173689403388-0.0234063460267112

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC6.518908036079e-070.2781007091625412.0697237006732e-070.2897596979588757.61487247795435e-370.638098681645995
AC4.10073973838353e-190.5250287922943442.30640568772249e-070.3201102965308091.16699542692443e-410.722653860598047
PCC6.89316424631338e-050.2838944536765720.001415425706086650.2293473660127411.76162110156514e-100.440737998530922
CER0.0103811706554299-0.2086936809094524.46182177917879e-05-0.3268405529857487.08011118347778e-050.318610105035487
TCX0.003315956460027440.2383191520661870.5880034089334340.04458315649539074.03869867552805e-050.328585918921881
FP6.94069830086493e-100.4414160959801190.06002740117746420.1412439710010049.97449911216868e-140.520158851270001
IFG0.0001185394637745640.6941656178072820.0007689716194248580.6283738735098970.02147407936318320.45751159989513
PG0.3366803105487720.07083423610411410.3386496535807110.07054679497715294.89872670917417e-090.412508998243481
STG6.14569206000816e-080.549613690774710.1251533404038340.1686443494795289.18732899628769e-070.50584283252797

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Relation with AD stages for LGI4

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
TCX3.72933830634702e-060.432163574456849

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RelatedDrugs for LGI4

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LGI4

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
LGI4C0003886Arthrogryposis3GENOMICS_ENGLAND
LGI4C0270960Congenital myopathy (disorder)3GENOMICS_ENGLAND
LGI4C3714756Intellectual Disability3GENOMICS_ENGLAND
LGI4C4479539ARTHROGRYPOSIS MULTIPLEX CONGENITA, NEUROGENIC, WITH MYELIN DEFECT1CTD_human;UNIPROT