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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for AMOT |
 Gene summary |
| Gene information | Gene symbol | AMOT | Gene ID | 154796 |
| Gene name | angiomotin | |
| Synonyms | - | |
| Cytomap | Xq23 | |
| Type of gene | protein-coding | |
| Description | angiomotinangiomotin p130 isoformangiomotin p80 isoform | |
| Modification date | 20200313 | |
| UniProtAcc | Q4VCS5, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| AMOT | GO:0016525 | negative regulation of angiogenesis | 11257124 |
| AMOT | GO:0030334 | regulation of cell migration | 11257124 |
| AMOT | GO:0034613 | cellular protein localization | 21205866 |
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RNA A-to-I events for AMOT |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1486297(112781393, -), ADediting_1486298(112781951, -), ADediting_1486299(112781956, -), ADediting_1486300(112781964, -), ADediting_1486301(112781986, -), ADediting_1486302(112782161, -), ADediting_1486303(112782162, -), ADediting_1486304(112782168, -), ADediting_1486305(112823008, -), |
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RNA editing positional annotations for AMOT using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_1486305 | chrX_112823008_- | nonsynonymous SNV | ENST00000371959.7 | c.A119G | p.Q40R | 0.0 | 0.989 | -3.26 |
| ADediting_1486305 | chrX_112823008_- | nonsynonymous SNV | ENST00000524145.5 | c.A119G | p.Q40R | 0.0 | 0.989 | -3.26 |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1486297 | chrX_112781393_- | intronic |
| ADediting_1486298 | chrX_112781951_- | intronic |
| ADediting_1486299 | chrX_112781956_- | intronic |
| ADediting_1486300 | chrX_112781964_- | intronic |
| ADediting_1486301 | chrX_112781986_- | intronic |
| ADediting_1486302 | chrX_112782161_- | intronic |
| ADediting_1486303 | chrX_112782162_- | intronic |
| ADediting_1486304 | chrX_112782168_- | intronic |
| ADediting_1486305 | chrX_112823008_- | exonic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1486297 | chrX_112781393_- | SINE | Alu | Name=AluSg |
| ADediting_1486298 | chrX_112781951_- | SINE | Alu | Name=AluSx1 |
| ADediting_1486299 | chrX_112781956_- | SINE | Alu | Name=AluSx1 |
| ADediting_1486300 | chrX_112781964_- | SINE | Alu | Name=AluSx1 |
| ADediting_1486301 | chrX_112781986_- | SINE | Alu | Name=AluSx1 |
| ADediting_1486302 | chrX_112782161_- | SINE | Alu | Name=AluSx1 |
| ADediting_1486303 | chrX_112782162_- | SINE | Alu | Name=AluSx1 |
| ADediting_1486304 | chrX_112782168_- | SINE | Alu | Name=AluSx1 |
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RNA A-to-I editing events in the alternative splicing sites for AMOT |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for AMOT |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for AMOT |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for AMOT |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-5688 | chrX | 112777521 | 112777528 | 8mer-1a | 112777521 | 112777542 | 145 | -14.1 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-5688 | chrX | 112777956 | 112777962 | 7mer-m8 | 112777955 | 112777976 | 150 | -15.07 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-5688 | chrX | 112777521 | 112777528 | 8mer-1a | 112777521 | 112777542 | 145 | -14.1 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-5688 | chrX | 112777956 | 112777962 | 7mer-m8 | 112777955 | 112777976 | 150 | -15.07 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-589-3p | chrX | 112777880 | 112777886 | 7mer-m8 | 112777879 | 112777902 | 148 | -13.89 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-589-3p | chrX | 112777880 | 112777886 | 7mer-m8 | 112777879 | 112777902 | 148 | -13.89 |
| ADediting_1337758 | chr7_5495892_- | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-589-5p | chrX | 112777914 | 112777920 | 7mer-m8 | 112777913 | 112777934 | 145 | -14.45 |
| ADediting_1337758 | chr7_5495892_- | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-589-5p | chrX | 112777914 | 112777920 | 7mer-m8 | 112777913 | 112777934 | 145 | -14.45 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-4477b | chrX | 112777403 | 112777409 | 7mer-m8 | 112777402 | 112777425 | 158 | -12.62 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-4477b | chrX | 112777403 | 112777409 | 7mer-m8 | 112777402 | 112777425 | 158 | -12.62 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-381-3p | chrX | 112777691 | 112777697 | 7mer-m8 | 112777690 | 112777709 | 161 | -17.14 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-381-3p | chrX | 112777691 | 112777697 | 7mer-m8 | 112777690 | 112777709 | 161 | -17.14 |
| ADediting_496066 | chr15_66496985_- | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-4512 | chrX | 112774550 | 112774556 | 7mer-m8 | 112774549 | 112774569 | 145 | -16.18 |
| ADediting_496066 | chr15_66496985_- | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-4512 | chrX | 112774550 | 112774556 | 7mer-m8 | 112774549 | 112774569 | 145 | -16.18 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-4775 | chrX | 112775651 | 112775657 | 7mer-m8 | 112775650 | 112775671 | 140 | -6.21 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-4775 | chrX | 112775651 | 112775657 | 7mer-m8 | 112775650 | 112775671 | 140 | -6.21 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-5688 | chrX | 112775150 | 112775156 | 7mer-m8 | 112775149 | 112775170 | 153 | -14.98 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-5688 | chrX | 112775150 | 112775156 | 7mer-m8 | 112775149 | 112775170 | 153 | -14.98 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-589-3p | chrX | 112774521 | 112774528 | 8mer-1a | 112774521 | 112774544 | 145 | -14.69 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-589-3p | chrX | 112774521 | 112774528 | 8mer-1a | 112774521 | 112774544 | 145 | -14.69 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-151a-3p | chrX | 112778392 | 112778398 | 7mer-m8 | 112778391 | 112778412 | 149 | -10.65 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-151a-3p | chrX | 112778392 | 112778398 | 7mer-m8 | 112778391 | 112778412 | 149 | -10.65 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-337-3p | chrX | 112776621 | 112776628 | 8mer-1a | 112776621 | 112776642 | 141 | -8.17 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-337-3p | chrX | 112776621 | 112776628 | 8mer-1a | 112776621 | 112776642 | 141 | -8.17 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-381-3p | chrX | 112778133 | 112778139 | 7mer-1a | 112778133 | 112778156 | 142 | -15.08 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-381-3p | chrX | 112778133 | 112778139 | 7mer-1a | 112778133 | 112778156 | 142 | -15.08 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-381-3p | chrX | 112778133 | 112778139 | 7mer-1a | 112778133 | 112778156 | 142 | -15.08 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-381-3p | chrX | 112778133 | 112778139 | 7mer-1a | 112778133 | 112778156 | 142 | -15.08 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-641 | chrX | 112775195 | 112775201 | 7mer-m8 | 112775194 | 112775219 | 150 | -15.81 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-641 | chrX | 112777103 | 112777110 | 8mer-1a | 112777103 | 112777127 | 149 | -18.04 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-641 | chrX | 112775195 | 112775201 | 7mer-m8 | 112775194 | 112775219 | 150 | -15.81 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-641 | chrX | 112777103 | 112777110 | 8mer-1a | 112777103 | 112777127 | 149 | -18.04 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-641 | chrX | 112775195 | 112775201 | 7mer-m8 | 112775194 | 112775219 | 150 | -15.81 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-641 | chrX | 112777103 | 112777110 | 8mer-1a | 112777103 | 112777127 | 149 | -18.04 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-641 | chrX | 112775195 | 112775201 | 7mer-m8 | 112775194 | 112775219 | 150 | -15.81 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-641 | chrX | 112777103 | 112777110 | 8mer-1a | 112777103 | 112777127 | 149 | -18.04 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000126016.15 | ENST00000304758.5 | AMOT-201 | hsa-miR-5682 | chrX | 112777742 | 112777748 | 7mer-m8 | 112777741 | 112777764 | 149 | -18.05 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000126016.15 | ENST00000371959.7 | AMOT-203 | hsa-miR-5682 | chrX | 112777742 | 112777748 | 7mer-m8 | 112777741 | 112777764 | 149 | -18.05 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for AMOT |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000371959.7 | protein_coding |  |  |
| ENST00000524145.5 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1486305 | ENST00000371959.7 | chrX_112823008_- | 119 | -2299.30 | -2298.10 | -2299.30 |
| ADediting_1486305 | ENST00000524145.5 | chrX_112823008_- | 194 | -1167.60 | -1167.90 | -1167.60 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for AMOT |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 2.25540694506247e-16 | 0.443546380131669 | 0.00969136409854705 | 0.146708834666324 | 5.82769096688182e-16 | 0.43798486049702 |
| AC | 9.21163593511853e-33 | 0.660906533166391 | 1.11213868950827e-16 | 0.492498487693342 | 1.29865398456546e-29 | 0.634878453662386 |
| PCC | 3.53688151930961e-09 | 0.410911496912609 | 7.76534809095782e-05 | 0.281950729406613 | 2.79172391706687e-14 | 0.514158207130935 |
| CER | 3.12408191830091e-12 | 0.529841333995686 | 0.00028574221135637 | 0.292170294573773 | 3.28073617717284e-16 | 0.602844689120005 |
| TCX | 6.9632254968035e-08 | 0.422961537712056 | 0.154413720983482 | 0.116857139771857 | 0.000113057099927656 | 0.31001676141295 |
| FP | 0.0460967215301884 | 0.149705755802973 | 0.0728877866751487 | -0.134766488010315 | 2.15167726674513e-11 | 0.474765484175152 |
| IFG | 1.37816443912886e-05 | 0.75340933596799 | 1.85893698545444e-05 | 0.746028747721326 | 0.000957579687899885 | 0.619544487276182 |
| PG | 1.46300183578997e-14 | 0.524901860451753 | 1.46385939356658e-06 | 0.344581576210097 | 0.000291363641138301 | 0.262730034170671 |
| STG | 0.166035745217689 | 0.152521428861195 | 0.414443870674479 | -0.0902136139183577 | 1.28452783402266e-08 | 0.572363053720857 |
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Relation with AD stages for AMOT |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 6.81947576838803e-07 | 0.456571568646516 |
| TCX | 1.4165516251231e-08 | 0.516802786766239 |
| PG | 2.37939362487072e-06 | 0.337997498256185 |
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RelatedDrugs for AMOT |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AMOT |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| AMOT | C0006118 | Brain Neoplasms | 1 | CTD_human |
| AMOT | C0153633 | Malignant neoplasm of brain | 1 | CTD_human |
| AMOT | C0496899 | Benign neoplasm of brain, unspecified | 1 | CTD_human |
| AMOT | C0750974 | Brain Tumor, Primary | 1 | CTD_human |
| AMOT | C0750977 | Recurrent Brain Neoplasm | 1 | CTD_human |
| AMOT | C0750979 | Primary malignant neoplasm of brain | 1 | CTD_human |
| AMOT | C1527390 | Neoplasms, Intracranial | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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