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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for TRMT44 |
 Gene summary |
| Gene information | Gene symbol | TRMT44 | Gene ID | 152992 |
| Gene name | tRNA methyltransferase 44 homolog | |
| Synonyms | C4orf23|METTL19|TRM44 | |
| Cytomap | 4p16.1 | |
| Type of gene | protein-coding | |
| Description | probable tRNA (uracil-O(2)-)-methyltransferasemethyltransferase like 19methyltransferase-like protein 19 | |
| Modification date | 20200313 | |
| UniProtAcc | Q8IYL2, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for TRMT44 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1150246(8452655, +), ADediting_1150249(8460786, +), ADediting_1150395(8470637, +), ADediting_1150476(8479917, +), ADediting_1150477(8479926, +), ADediting_1150478(8479955, +), ADediting_1150479(8480006, +), ADediting_1150480(8480010, +), ADediting_1150543(8489540, +), |
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RNA editing positional annotations for TRMT44 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1150246 | chr4_8452655_+ | intronic |
| ADediting_1150249 | chr4_8460786_+ | intronic |
| ADediting_1150395 | chr4_8470637_+ | intronic |
| ADediting_1150476 | chr4_8479917_+ | intergenic |
| ADediting_1150477 | chr4_8479926_+ | intergenic |
| ADediting_1150478 | chr4_8479955_+ | intergenic |
| ADediting_1150479 | chr4_8480006_+ | intergenic |
| ADediting_1150480 | chr4_8480010_+ | intergenic |
| ADediting_1150543 | chr4_8489540_+ | ncRNA_intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1150246 | chr4_8452655_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1150249 | chr4_8460786_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1150476 | chr4_8479917_+ | SINE | Alu | Name=AluJb |
| ADediting_1150477 | chr4_8479926_+ | SINE | Alu | Name=AluJb |
| ADediting_1150478 | chr4_8479955_+ | SINE | Alu | Name=AluJb |
| ADediting_1150479 | chr4_8480006_+ | SINE | Alu | Name=AluJb |
| ADediting_1150480 | chr4_8480010_+ | SINE | Alu | Name=AluJb |
| ADediting_1150543 | chr4_8489540_+ | SINE | Alu | Name=AluSx1 |
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RNA A-to-I editing events in the alternative splicing sites for TRMT44 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TRMT44 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for TRMT44 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for TRMT44 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_107020 | chr1_37500952_- | ENSG00000155275.19 | ENST00000389737.5 | TRMT44-201 | hsa-miR-5581-3p | chr4 | 8476270 | 8476276 | 7mer-m8 | 8476256 | 8476277 | 140 | -13.08 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000155275.19 | ENST00000389737.5 | TRMT44-201 | hsa-miR-589-3p | chr4 | 8476083 | 8476089 | 7mer-m8 | 8476067 | 8476090 | 151 | -19.34 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000155275.19 | ENST00000389737.5 | TRMT44-201 | hsa-miR-589-3p | chr4 | 8476444 | 8476450 | 7mer-m8 | 8476431 | 8476451 | 150 | -26.46 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000155275.19 | ENST00000389737.5 | TRMT44-201 | hsa-miR-641 | chr4 | 8476285 | 8476291 | 7mer-m8 | 8476270 | 8476292 | 153 | -16.06 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_496066 | chr15_66496985_- | ENSG00000155275.19 | ENST00000389737.5 | TRMT44-201 | hsa-miR-4512 | chr4 | 8476323 | 8476329 | 7mer-m8 | 8476311 | 8476330 | 144 | -16.59 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for TRMT44 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for TRMT44 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_1150477 | chr4_8479926_+ | 0.416290289512555 | 0.0463305089459951 | 0.258767085607211 | -0.0643339261013215 | 2.77071904224712e-18 | 0.46807176055079 |
| DLPFC | ADediting_1150479 | chr4_8480006_+ | 0.720640519984369 | 0.0203907407060443 | 0.335018722252492 | -0.054935169461671 | 6.67960080262165e-09 | 0.321844955804985 |
| DLPFC | ADediting_1150480 | chr4_8480010_+ | 0.803579904200598 | 0.0141827455211017 | 0.21846826736754 | -0.0700911882780429 | 7.98536478694278e-10 | 0.339948970609117 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 9.43194209908581e-23 | 0.518729221411724 | 1.24725428542993e-19 | 0.484244822030279 | 0.000131337660066732 | 0.215498356733854 |
| PCC | 0.000922666648080059 | 0.237839617673941 | 0.000448093135181473 | 0.251530731793701 | 1.50709574540619e-05 | 0.30753387960524 |
| CER | 5.95153638711509e-31 | 0.772205629904918 | 1.12127483476397e-16 | 0.610319349871907 | 0.00376573851877653 | 0.235191044404638 |
| TCX | 1.1337946374919e-20 | 0.667230834554893 | 1.16714157395943e-07 | 0.416306154665773 | 5.11371989168488e-06 | 0.362609662620098 |
| FP | 5.02175108656149e-25 | 0.675047987867877 | 1.08696253746715e-17 | 0.584438071579548 | 4.27335350323208e-09 | 0.422414544107043 |
| IFG | 0.000530868590310087 | 0.64270795470295 | 8.64376800433614e-05 | 0.703831924502974 | 0.004596505636224 | 0.547701947439168 |
| PG | 8.62633562078816e-17 | 0.560682602902041 | 4.02741369545918e-18 | 0.580161249784117 | 0.123330163053523 | 0.11338725442939 |
| STG | 2.53047913247886e-12 | 0.672238976881914 | 6.92906874020348e-08 | 0.547797852265393 | 0.000860698558482326 | 0.356899975861127 |
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Relation with AD stages for TRMT44 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 4.98030809352811e-06 | 0.423405550271255 |
| TCX | 7.33973213978655e-07 | 0.459287833620748 |
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RelatedDrugs for TRMT44 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRMT44 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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