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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for PPM1L |
 Gene summary |
| Gene information | Gene symbol | PPM1L | Gene ID | 151742 |
| Gene name | protein phosphatase, Mg2+/Mn2+ dependent 1L | |
| Synonyms | PP2C-epsilon|PP2CE|PPM1-LIKE | |
| Cytomap | 3q25.33-q26.1 | |
| Type of gene | protein-coding | |
| Description | protein phosphatase 1LPP2C epsilonProtein phosphatase 2C epsilon isoformprotein phosphatase 2C isoform epsilon | |
| Modification date | 20200313 | |
| UniProtAcc | Q5SGD2, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for PPM1L |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_1035567(160761700, +), ADediting_1035568(160761708, +), ADediting_1035569(160761713, +), ADediting_1035570(160761731, +), ADediting_1035571(160761732, +), ADediting_1035572(160761736, +), ADediting_1035573(160761744, +), ADediting_1035574(160761745, +), ADediting_1035575(160761774, +), ADediting_1035576(160766353, +), ADediting_1035577(160766608, +), ADediting_1035578(160766609, +), ADediting_1035579(160776704, +), ADediting_1035580(160776720, +), ADediting_1035581(160776740, +), ADediting_1035582(160776781, +), ADediting_1035583(160776801, +), ADediting_1035584(160776861, +), ADediting_1035585(160776873, +), ADediting_1035586(160777067, +), ADediting_1035587(160777141, +), ADediting_1035588(160777152, +), ADediting_1035589(160777158, +), ADediting_1035590(160777308, +), ADediting_1035591(160783344, +), ADediting_1035592(160783362, +), ADediting_1035593(160783367, +), ADediting_1035594(160783453, +), ADediting_1035595(160783480, +), ADediting_1035596(160783521, +), ADediting_1035597(160803971, +), ADediting_1035598(160803982, +), ADediting_1035599(160803998, +), ADediting_1035600(160804011, +), ADediting_1035601(160804057, +), ADediting_1035602(160804139, +), ADediting_1035603(160804143, +), ADediting_1035604(160804184, +), ADediting_1035605(160805484, +), ADediting_1035606(160805493, +), ADediting_1035607(160805520, +), ADediting_1035608(160805521, +), ADediting_1035609(160805546, +), ADediting_1035610(160805643, +), ADediting_1035611(160805647, +), ADediting_1035612(160805687, +), ADediting_1035613(160822822, +), ADediting_1035614(160822834, +), ADediting_1035615(160822866, +), ADediting_1035616(160822872, +), ADediting_1035617(160822903, +), ADediting_1035618(160848288, +), ADediting_1035619(160848298, +), ADediting_1035620(160848299, +), ADediting_1035621(160848307, +), ADediting_1035622(160848322, +), ADediting_1035623(160848327, +), ADediting_1035624(160848328, +), ADediting_1035625(160848349, +), ADediting_1035626(160848352, +), ADediting_1035627(160850278, +), ADediting_1035628(160850310, +), ADediting_1035629(160850311, +), ADediting_1035630(160850322, +), ADediting_1035631(160850325, +), ADediting_1035632(160850340, +), ADediting_1035633(160850341, +), ADediting_1035634(160864206, +), ADediting_1035635(160864269, +), ADediting_1035636(160864429, +), ADediting_1035637(160865520, +), ADediting_1035638(160865521, +), ADediting_1035639(160872671, +), ADediting_1035640(160872672, +), ADediting_1035641(160872724, +), ADediting_1035642(160872775, +), ADediting_1035643(160872780, +), ADediting_1035644(160872836, +), ADediting_1035645(160872839, +), ADediting_1035646(160872848, +), ADediting_1035647(160872872, +), ADediting_1035648(160872890, +), ADediting_1035649(160873596, +), ADediting_1035650(160873647, +), ADediting_1035651(160873651, +), ADediting_1035652(160873677, +), ADediting_1035653(160873713, +), ADediting_1035654(160873714, +), ADediting_1035655(160873747, +), ADediting_1035656(160873776, +), ADediting_1035657(160936353, +), ADediting_1035658(160936365, +), ADediting_1035659(160937499, +), ADediting_1035660(160964997, +), ADediting_1035661(160978817, +), ADediting_1035662(160980413, +), ADediting_1035663(160980588, +), ADediting_1035664(160981816, +), ADediting_1035665(160981856, +), ADediting_1035666(160981863, +), ADediting_1035667(160981892, +), ADediting_1035668(160982048, +), ADediting_1035669(160996203, +), ADediting_1035670(161019263, +), ADediting_1035671(161019294, +), ADediting_1035672(161019311, +), ADediting_1035673(161019312, +), ADediting_1035674(161019873, +), ADediting_1035675(161019877, +), ADediting_1035676(161019908, +), ADediting_1035677(161019913, +), ADediting_1035678(161020006, +), ADediting_1035679(161020019, +), ADediting_1035680(161020022, +), ADediting_1035681(161020038, +), ADediting_1035682(161020075, +), ADediting_1035683(161020076, +), ADediting_1035684(161020101, +), ADediting_1035685(161022938, +), ADediting_1035686(161024052, +), ADediting_1035687(161024067, +), ADediting_1035688(161024144, +), ADediting_1035689(161026576, +), ADediting_1035690(161026602, +), ADediting_1035691(161037484, +), ADediting_1035692(161038441, +), ADediting_1035693(161038445, +), ADediting_1035694(161038451, +), ADediting_1035695(161038454, +), ADediting_1035696(161038497, +), ADediting_1035697(161042975, +), ADediting_1035698(161049227, +), ADediting_1035699(161073082, +), ADediting_1035700(161073083, +), ADediting_1035701(161073588, +), ADediting_1035702(161073655, +), ADediting_1035703(161073663, +), ADediting_1035704(161073701, +), ADediting_1035705(161073743, +), ADediting_1035706(161073768, +), ADediting_1035707(161073823, +), ADediting_1645473(160761701, +), ADediting_1645474(160761712, +), ADediting_1645475(160776635, +), ADediting_1645476(160776766, +), ADediting_1645477(160776767, +), ADediting_1645478(160776784, +), ADediting_1645479(160776790, +), ADediting_1645480(160776810, +), ADediting_1645481(160776860, +), ADediting_1645482(160776875, +), ADediting_1645483(160777068, +), ADediting_1645484(160777113, +), ADediting_1645485(160777121, +), ADediting_1645486(160777122, +), ADediting_1645487(160777137, +), ADediting_1645488(160777139, +), ADediting_1645489(160777161, +), ADediting_1645490(160777163, +), ADediting_1645491(160805466, +), ADediting_1645492(160822742, +), ADediting_1645493(160848326, +), ADediting_1645494(160848348, +), ADediting_1645495(160864252, +), ADediting_1645496(160864257, +), ADediting_1645497(160864303, +), ADediting_1645498(160865610, +), ADediting_1645499(161019273, +), ADediting_1645500(161019323, +), ADediting_1645501(161019382, +), |
Top |
RNA editing positional annotations for PPM1L using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1035567 | chr3_160761700_+ | intronic |
| ADediting_1035568 | chr3_160761708_+ | intronic |
| ADediting_1035569 | chr3_160761713_+ | intronic |
| ADediting_1035570 | chr3_160761731_+ | intronic |
| ADediting_1035571 | chr3_160761732_+ | intronic |
| ADediting_1035572 | chr3_160761736_+ | intronic |
| ADediting_1035573 | chr3_160761744_+ | intronic |
| ADediting_1035574 | chr3_160761745_+ | intronic |
| ADediting_1035575 | chr3_160761774_+ | intronic |
| ADediting_1035576 | chr3_160766353_+ | intronic |
| ADediting_1035577 | chr3_160766608_+ | intronic |
| ADediting_1035578 | chr3_160766609_+ | intronic |
| ADediting_1035579 | chr3_160776704_+ | intronic |
| ADediting_1035580 | chr3_160776720_+ | intronic |
| ADediting_1035581 | chr3_160776740_+ | intronic |
| ADediting_1035582 | chr3_160776781_+ | intronic |
| ADediting_1035583 | chr3_160776801_+ | intronic |
| ADediting_1035584 | chr3_160776861_+ | intronic |
| ADediting_1035585 | chr3_160776873_+ | intronic |
| ADediting_1035586 | chr3_160777067_+ | intronic |
| ADediting_1035587 | chr3_160777141_+ | intronic |
| ADediting_1035588 | chr3_160777152_+ | intronic |
| ADediting_1035589 | chr3_160777158_+ | intronic |
| ADediting_1035590 | chr3_160777308_+ | intronic |
| ADediting_1035591 | chr3_160783344_+ | intronic |
| ADediting_1035592 | chr3_160783362_+ | intronic |
| ADediting_1035593 | chr3_160783367_+ | intronic |
| ADediting_1035594 | chr3_160783453_+ | intronic |
| ADediting_1035595 | chr3_160783480_+ | intronic |
| ADediting_1035596 | chr3_160783521_+ | intronic |
| ADediting_1035597 | chr3_160803971_+ | intronic |
| ADediting_1035598 | chr3_160803982_+ | intronic |
| ADediting_1035599 | chr3_160803998_+ | intronic |
| ADediting_1035600 | chr3_160804011_+ | intronic |
| ADediting_1035601 | chr3_160804057_+ | intronic |
| ADediting_1035602 | chr3_160804139_+ | intronic |
| ADediting_1035603 | chr3_160804143_+ | intronic |
| ADediting_1035604 | chr3_160804184_+ | intronic |
| ADediting_1035605 | chr3_160805484_+ | intronic |
| ADediting_1035606 | chr3_160805493_+ | intronic |
| ADediting_1035607 | chr3_160805520_+ | intronic |
| ADediting_1035608 | chr3_160805521_+ | intronic |
| ADediting_1035609 | chr3_160805546_+ | intronic |
| ADediting_1035610 | chr3_160805643_+ | intronic |
| ADediting_1035611 | chr3_160805647_+ | intronic |
| ADediting_1035612 | chr3_160805687_+ | intronic |
| ADediting_1035613 | chr3_160822822_+ | intronic |
| ADediting_1035614 | chr3_160822834_+ | intronic |
| ADediting_1035615 | chr3_160822866_+ | intronic |
| ADediting_1035616 | chr3_160822872_+ | intronic |
| ADediting_1035617 | chr3_160822903_+ | intronic |
| ADediting_1035618 | chr3_160848288_+ | intronic |
| ADediting_1035619 | chr3_160848298_+ | intronic |
| ADediting_1035620 | chr3_160848299_+ | intronic |
| ADediting_1035621 | chr3_160848307_+ | intronic |
| ADediting_1035622 | chr3_160848322_+ | intronic |
| ADediting_1035623 | chr3_160848327_+ | intronic |
| ADediting_1035624 | chr3_160848328_+ | intronic |
| ADediting_1035625 | chr3_160848349_+ | intronic |
| ADediting_1035626 | chr3_160848352_+ | intronic |
| ADediting_1035627 | chr3_160850278_+ | intronic |
| ADediting_1035628 | chr3_160850310_+ | intronic |
| ADediting_1035629 | chr3_160850311_+ | intronic |
| ADediting_1035630 | chr3_160850322_+ | intronic |
| ADediting_1035631 | chr3_160850325_+ | intronic |
| ADediting_1035632 | chr3_160850340_+ | intronic |
| ADediting_1035633 | chr3_160850341_+ | intronic |
| ADediting_1035634 | chr3_160864206_+ | intronic |
| ADediting_1035635 | chr3_160864269_+ | intronic |
| ADediting_1035636 | chr3_160864429_+ | intronic |
| ADediting_1035637 | chr3_160865520_+ | intronic |
| ADediting_1035638 | chr3_160865521_+ | intronic |
| ADediting_1035639 | chr3_160872671_+ | intronic |
| ADediting_1035640 | chr3_160872672_+ | intronic |
| ADediting_1035641 | chr3_160872724_+ | intronic |
| ADediting_1035642 | chr3_160872775_+ | intronic |
| ADediting_1035643 | chr3_160872780_+ | intronic |
| ADediting_1035644 | chr3_160872836_+ | intronic |
| ADediting_1035645 | chr3_160872839_+ | intronic |
| ADediting_1035646 | chr3_160872848_+ | intronic |
| ADediting_1035647 | chr3_160872872_+ | intronic |
| ADediting_1035648 | chr3_160872890_+ | intronic |
| ADediting_1035649 | chr3_160873596_+ | intronic |
| ADediting_1035650 | chr3_160873647_+ | intronic |
| ADediting_1035651 | chr3_160873651_+ | intronic |
| ADediting_1035652 | chr3_160873677_+ | intronic |
| ADediting_1035653 | chr3_160873713_+ | intronic |
| ADediting_1035654 | chr3_160873714_+ | intronic |
| ADediting_1035655 | chr3_160873747_+ | intronic |
| ADediting_1035656 | chr3_160873776_+ | intronic |
| ADediting_1035657 | chr3_160936353_+ | intronic |
| ADediting_1035658 | chr3_160936365_+ | intronic |
| ADediting_1035659 | chr3_160937499_+ | intronic |
| ADediting_1035660 | chr3_160964997_+ | intronic |
| ADediting_1035661 | chr3_160978817_+ | intronic |
| ADediting_1035662 | chr3_160980413_+ | intronic |
| ADediting_1035663 | chr3_160980588_+ | intronic |
| ADediting_1035664 | chr3_160981816_+ | intronic |
| ADediting_1035665 | chr3_160981856_+ | intronic |
| ADediting_1035666 | chr3_160981863_+ | intronic |
| ADediting_1035667 | chr3_160981892_+ | intronic |
| ADediting_1035668 | chr3_160982048_+ | intronic |
| ADediting_1035669 | chr3_160996203_+ | intronic |
| ADediting_1035670 | chr3_161019263_+ | intronic |
| ADediting_1035671 | chr3_161019294_+ | intronic |
| ADediting_1035672 | chr3_161019311_+ | intronic |
| ADediting_1035673 | chr3_161019312_+ | intronic |
| ADediting_1035674 | chr3_161019873_+ | intronic |
| ADediting_1035675 | chr3_161019877_+ | intronic |
| ADediting_1035676 | chr3_161019908_+ | intronic |
| ADediting_1035677 | chr3_161019913_+ | intronic |
| ADediting_1035678 | chr3_161020006_+ | intronic |
| ADediting_1035679 | chr3_161020019_+ | intronic |
| ADediting_1035680 | chr3_161020022_+ | intronic |
| ADediting_1035681 | chr3_161020038_+ | intronic |
| ADediting_1035682 | chr3_161020075_+ | intronic |
| ADediting_1035683 | chr3_161020076_+ | intronic |
| ADediting_1035684 | chr3_161020101_+ | intronic |
| ADediting_1035685 | chr3_161022938_+ | intronic |
| ADediting_1035686 | chr3_161024052_+ | intronic |
| ADediting_1035687 | chr3_161024067_+ | intronic |
| ADediting_1035688 | chr3_161024144_+ | intronic |
| ADediting_1035689 | chr3_161026576_+ | intronic |
| ADediting_1035690 | chr3_161026602_+ | intronic |
| ADediting_1035691 | chr3_161037484_+ | intronic |
| ADediting_1035692 | chr3_161038441_+ | intronic |
| ADediting_1035693 | chr3_161038445_+ | intronic |
| ADediting_1035694 | chr3_161038451_+ | intronic |
| ADediting_1035695 | chr3_161038454_+ | intronic |
| ADediting_1035696 | chr3_161038497_+ | intronic |
| ADediting_1035697 | chr3_161042975_+ | intronic |
| ADediting_1035698 | chr3_161049227_+ | intronic |
| ADediting_1035699 | chr3_161073082_+ | UTR3 |
| ADediting_1035700 | chr3_161073083_+ | UTR3 |
| ADediting_1035701 | chr3_161073588_+ | UTR3 |
| ADediting_1035702 | chr3_161073655_+ | UTR3 |
| ADediting_1035703 | chr3_161073663_+ | UTR3 |
| ADediting_1035704 | chr3_161073701_+ | UTR3 |
| ADediting_1035705 | chr3_161073743_+ | UTR3 |
| ADediting_1035706 | chr3_161073768_+ | UTR3 |
| ADediting_1035707 | chr3_161073823_+ | UTR3 |
| ADediting_1645473 | chr3_160761701_+ | intronic |
| ADediting_1645474 | chr3_160761712_+ | intronic |
| ADediting_1645475 | chr3_160776635_+ | intronic |
| ADediting_1645476 | chr3_160776766_+ | intronic |
| ADediting_1645477 | chr3_160776767_+ | intronic |
| ADediting_1645478 | chr3_160776784_+ | intronic |
| ADediting_1645479 | chr3_160776790_+ | intronic |
| ADediting_1645480 | chr3_160776810_+ | intronic |
| ADediting_1645481 | chr3_160776860_+ | intronic |
| ADediting_1645482 | chr3_160776875_+ | intronic |
| ADediting_1645483 | chr3_160777068_+ | intronic |
| ADediting_1645484 | chr3_160777113_+ | intronic |
| ADediting_1645485 | chr3_160777121_+ | intronic |
| ADediting_1645486 | chr3_160777122_+ | intronic |
| ADediting_1645487 | chr3_160777137_+ | intronic |
| ADediting_1645488 | chr3_160777139_+ | intronic |
| ADediting_1645489 | chr3_160777161_+ | intronic |
| ADediting_1645490 | chr3_160777163_+ | intronic |
| ADediting_1645491 | chr3_160805466_+ | intronic |
| ADediting_1645492 | chr3_160822742_+ | intronic |
| ADediting_1645493 | chr3_160848326_+ | intronic |
| ADediting_1645494 | chr3_160848348_+ | intronic |
| ADediting_1645495 | chr3_160864252_+ | intronic |
| ADediting_1645496 | chr3_160864257_+ | intronic |
| ADediting_1645497 | chr3_160864303_+ | intronic |
| ADediting_1645498 | chr3_160865610_+ | intronic |
| ADediting_1645499 | chr3_161019273_+ | intronic |
| ADediting_1645500 | chr3_161019323_+ | intronic |
| ADediting_1645501 | chr3_161019382_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1035567 | chr3_160761700_+ | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1035568 | chr3_160761708_+ | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1035569 | chr3_160761713_+ | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1035570 | chr3_160761731_+ | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1035571 | chr3_160761732_+ | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1035572 | chr3_160761736_+ | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1035573 | chr3_160761744_+ | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1035574 | chr3_160761745_+ | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1035575 | chr3_160761774_+ | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1035576 | chr3_160766353_+ | LTR | ERVL-MaLR | Name=THE1C |
| ADediting_1035577 | chr3_160766608_+ | LTR | ERVL-MaLR | Name=THE1C |
| ADediting_1035578 | chr3_160766609_+ | LTR | ERVL-MaLR | Name=THE1C |
| ADediting_1035579 | chr3_160776704_+ | SINE | Alu | Name=AluSg |
| ADediting_1035580 | chr3_160776720_+ | SINE | Alu | Name=AluSg |
| ADediting_1035581 | chr3_160776740_+ | SINE | Alu | Name=AluSg |
| ADediting_1035582 | chr3_160776781_+ | SINE | Alu | Name=AluSg |
| ADediting_1035583 | chr3_160776801_+ | SINE | Alu | Name=AluSg |
| ADediting_1035584 | chr3_160776861_+ | SINE | Alu | Name=AluSg |
| ADediting_1035585 | chr3_160776873_+ | SINE | Alu | Name=AluSg |
| ADediting_1035586 | chr3_160777067_+ | SINE | Alu | Name=AluJr |
| ADediting_1035587 | chr3_160777141_+ | SINE | Alu | Name=AluJr |
| ADediting_1035588 | chr3_160777152_+ | SINE | Alu | Name=AluJr |
| ADediting_1035589 | chr3_160777158_+ | SINE | Alu | Name=AluJr |
| ADediting_1035590 | chr3_160777308_+ | SINE | Alu | Name=AluJr |
| ADediting_1035591 | chr3_160783344_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1035592 | chr3_160783362_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1035593 | chr3_160783367_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1035594 | chr3_160783453_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1035595 | chr3_160783480_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1035596 | chr3_160783521_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1035597 | chr3_160803971_+ | SINE | Alu | Name=AluY |
| ADediting_1035598 | chr3_160803982_+ | SINE | Alu | Name=AluY |
| ADediting_1035599 | chr3_160803998_+ | SINE | Alu | Name=AluY |
| ADediting_1035600 | chr3_160804011_+ | SINE | Alu | Name=AluY |
| ADediting_1035601 | chr3_160804057_+ | SINE | Alu | Name=AluY |
| ADediting_1035602 | chr3_160804139_+ | SINE | Alu | Name=AluY |
| ADediting_1035603 | chr3_160804143_+ | SINE | Alu | Name=AluY |
| ADediting_1035604 | chr3_160804184_+ | SINE | Alu | Name=AluY |
| ADediting_1035605 | chr3_160805484_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1035606 | chr3_160805493_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1035607 | chr3_160805520_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1035608 | chr3_160805521_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1035609 | chr3_160805546_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1035610 | chr3_160805643_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1035611 | chr3_160805647_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1035612 | chr3_160805687_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1035613 | chr3_160822822_+ | LINE | L2 | Name=L2a |
| ADediting_1035614 | chr3_160822834_+ | LINE | L2 | Name=L2a |
| ADediting_1035618 | chr3_160848288_+ | LINE | L2 | Name=L2 |
| ADediting_1035619 | chr3_160848298_+ | LINE | L2 | Name=L2 |
| ADediting_1035620 | chr3_160848299_+ | LINE | L2 | Name=L2 |
| ADediting_1035621 | chr3_160848307_+ | LINE | L2 | Name=L2 |
| ADediting_1035622 | chr3_160848322_+ | LINE | L2 | Name=L2 |
| ADediting_1035623 | chr3_160848327_+ | LINE | L2 | Name=L2 |
| ADediting_1035624 | chr3_160848328_+ | LINE | L2 | Name=L2 |
| ADediting_1035625 | chr3_160848349_+ | LINE | L2 | Name=L2 |
| ADediting_1035626 | chr3_160848352_+ | LINE | L2 | Name=L2 |
| ADediting_1035627 | chr3_160850278_+ | LTR | ERVL | Name=MER21C |
| ADediting_1035628 | chr3_160850310_+ | LTR | ERVL | Name=MER21C |
| ADediting_1035629 | chr3_160850311_+ | LTR | ERVL | Name=MER21C |
| ADediting_1035630 | chr3_160850322_+ | LTR | ERVL | Name=MER21C |
| ADediting_1035631 | chr3_160850325_+ | LTR | ERVL | Name=MER21C |
| ADediting_1035632 | chr3_160850340_+ | LTR | ERVL | Name=MER21C |
| ADediting_1035633 | chr3_160850341_+ | LTR | ERVL | Name=MER21C |
| ADediting_1035634 | chr3_160864206_+ | SINE | Alu | Name=AluJb |
| ADediting_1035635 | chr3_160864269_+ | SINE | Alu | Name=AluJb |
| ADediting_1035636 | chr3_160864429_+ | SINE | Alu | Name=AluJb |
| ADediting_1035637 | chr3_160865520_+ | SINE | Alu | Name=AluSc |
| ADediting_1035638 | chr3_160865521_+ | SINE | Alu | Name=AluSc |
| ADediting_1035639 | chr3_160872671_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1035640 | chr3_160872672_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1035641 | chr3_160872724_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1035642 | chr3_160872775_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1035643 | chr3_160872780_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1035644 | chr3_160872836_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1035645 | chr3_160872839_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1035646 | chr3_160872848_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1035647 | chr3_160872872_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1035648 | chr3_160872890_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1035649 | chr3_160873596_+ | SINE | Alu | Name=AluSz |
| ADediting_1035650 | chr3_160873647_+ | SINE | Alu | Name=AluSz |
| ADediting_1035651 | chr3_160873651_+ | SINE | Alu | Name=AluSz |
| ADediting_1035652 | chr3_160873677_+ | SINE | Alu | Name=AluSz |
| ADediting_1035653 | chr3_160873713_+ | SINE | Alu | Name=AluSz |
| ADediting_1035654 | chr3_160873714_+ | SINE | Alu | Name=AluSz |
| ADediting_1035655 | chr3_160873747_+ | SINE | Alu | Name=AluSz |
| ADediting_1035656 | chr3_160873776_+ | SINE | Alu | Name=AluSz |
| ADediting_1035657 | chr3_160936353_+ | SINE | Alu | Name=AluSq4 |
| ADediting_1035658 | chr3_160936365_+ | SINE | Alu | Name=AluSq4 |
| ADediting_1035659 | chr3_160937499_+ | SINE | Alu | Name=AluY |
| ADediting_1035660 | chr3_160964997_+ | SINE | Alu | Name=AluY |
| ADediting_1035661 | chr3_160978817_+ | SINE | Alu | Name=AluJb |
| ADediting_1035662 | chr3_160980413_+ | SINE | Alu | Name=AluJb |
| ADediting_1035663 | chr3_160980588_+ | SINE | Alu | Name=AluJb |
| ADediting_1035664 | chr3_160981816_+ | SINE | Alu | Name=AluSz |
| ADediting_1035665 | chr3_160981856_+ | SINE | Alu | Name=AluSz |
| ADediting_1035666 | chr3_160981863_+ | SINE | Alu | Name=AluSz |
| ADediting_1035667 | chr3_160981892_+ | SINE | Alu | Name=AluSz |
| ADediting_1035668 | chr3_160982048_+ | SINE | Alu | Name=AluSz |
| ADediting_1035669 | chr3_160996203_+ | LINE | L1 | Name=L1PB1 |
| ADediting_1035670 | chr3_161019263_+ | SINE | Alu | Name=AluJr |
| ADediting_1035671 | chr3_161019294_+ | SINE | Alu | Name=AluJr |
| ADediting_1035672 | chr3_161019311_+ | SINE | Alu | Name=AluJr |
| ADediting_1035673 | chr3_161019312_+ | SINE | Alu | Name=AluJr |
| ADediting_1035674 | chr3_161019873_+ | SINE | Alu | Name=AluSc5 |
| ADediting_1035675 | chr3_161019877_+ | SINE | Alu | Name=AluSc5 |
| ADediting_1035676 | chr3_161019908_+ | SINE | Alu | Name=AluSc5 |
| ADediting_1035677 | chr3_161019913_+ | SINE | Alu | Name=AluSc5 |
| ADediting_1035678 | chr3_161020006_+ | SINE | Alu | Name=AluSc5 |
| ADediting_1035679 | chr3_161020019_+ | SINE | Alu | Name=AluSc5 |
| ADediting_1035680 | chr3_161020022_+ | SINE | Alu | Name=AluSc5 |
| ADediting_1035681 | chr3_161020038_+ | SINE | Alu | Name=AluSc5 |
| ADediting_1035682 | chr3_161020075_+ | SINE | Alu | Name=AluSc5 |
| ADediting_1035683 | chr3_161020076_+ | SINE | Alu | Name=AluSc5 |
| ADediting_1035684 | chr3_161020101_+ | SINE | Alu | Name=AluSc5 |
| ADediting_1035685 | chr3_161022938_+ | SINE | Alu | Name=AluY |
| ADediting_1035686 | chr3_161024052_+ | SINE | Alu | Name=AluSz |
| ADediting_1035687 | chr3_161024067_+ | SINE | Alu | Name=AluSz |
| ADediting_1035688 | chr3_161024144_+ | SINE | Alu | Name=AluSz |
| ADediting_1035689 | chr3_161026576_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1035690 | chr3_161026602_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1035691 | chr3_161037484_+ | SINE | Alu | Name=AluSp |
| ADediting_1035692 | chr3_161038441_+ | SINE | Alu | Name=AluJr |
| ADediting_1035693 | chr3_161038445_+ | SINE | Alu | Name=AluJr |
| ADediting_1035694 | chr3_161038451_+ | SINE | Alu | Name=AluJr |
| ADediting_1035695 | chr3_161038454_+ | SINE | Alu | Name=AluJr |
| ADediting_1035696 | chr3_161038497_+ | SINE | Alu | Name=AluJr |
| ADediting_1035697 | chr3_161042975_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1035698 | chr3_161049227_+ | SINE | Alu | Name=AluJb |
| ADediting_1035699 | chr3_161073082_+ | DNA | hAT-Charlie | Name=MER103C |
| ADediting_1035700 | chr3_161073083_+ | DNA | hAT-Charlie | Name=MER103C |
| ADediting_1035701 | chr3_161073588_+ | SINE | Alu | Name=AluY |
| ADediting_1035702 | chr3_161073655_+ | SINE | Alu | Name=AluY |
| ADediting_1035703 | chr3_161073663_+ | SINE | Alu | Name=AluY |
| ADediting_1035704 | chr3_161073701_+ | SINE | Alu | Name=AluY |
| ADediting_1035705 | chr3_161073743_+ | SINE | Alu | Name=AluY |
| ADediting_1035706 | chr3_161073768_+ | SINE | Alu | Name=AluY |
| ADediting_1035707 | chr3_161073823_+ | SINE | Alu | Name=AluY |
| ADediting_1645473 | chr3_160761701_+ | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1645474 | chr3_160761712_+ | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1645475 | chr3_160776635_+ | SINE | Alu | Name=AluSg |
| ADediting_1645476 | chr3_160776766_+ | SINE | Alu | Name=AluSg |
| ADediting_1645477 | chr3_160776767_+ | SINE | Alu | Name=AluSg |
| ADediting_1645478 | chr3_160776784_+ | SINE | Alu | Name=AluSg |
| ADediting_1645479 | chr3_160776790_+ | SINE | Alu | Name=AluSg |
| ADediting_1645480 | chr3_160776810_+ | SINE | Alu | Name=AluSg |
| ADediting_1645481 | chr3_160776860_+ | SINE | Alu | Name=AluSg |
| ADediting_1645482 | chr3_160776875_+ | SINE | Alu | Name=AluSg |
| ADediting_1645483 | chr3_160777068_+ | SINE | Alu | Name=AluJr |
| ADediting_1645484 | chr3_160777113_+ | SINE | Alu | Name=AluJr |
| ADediting_1645485 | chr3_160777121_+ | SINE | Alu | Name=AluJr |
| ADediting_1645486 | chr3_160777122_+ | SINE | Alu | Name=AluJr |
| ADediting_1645487 | chr3_160777137_+ | SINE | Alu | Name=AluJr |
| ADediting_1645488 | chr3_160777139_+ | SINE | Alu | Name=AluJr |
| ADediting_1645489 | chr3_160777161_+ | SINE | Alu | Name=AluJr |
| ADediting_1645490 | chr3_160777163_+ | SINE | Alu | Name=AluJr |
| ADediting_1645491 | chr3_160805466_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1645493 | chr3_160848326_+ | LINE | L2 | Name=L2 |
| ADediting_1645494 | chr3_160848348_+ | LINE | L2 | Name=L2 |
| ADediting_1645495 | chr3_160864252_+ | SINE | Alu | Name=AluJb |
| ADediting_1645496 | chr3_160864257_+ | SINE | Alu | Name=AluJb |
| ADediting_1645497 | chr3_160864303_+ | SINE | Alu | Name=AluJb |
| ADediting_1645498 | chr3_160865610_+ | SINE | Alu | Name=AluSc |
| ADediting_1645499 | chr3_161019273_+ | SINE | Alu | Name=AluJr |
| ADediting_1645500 | chr3_161019323_+ | SINE | Alu | Name=AluJr |
| ADediting_1645501 | chr3_161019382_+ | SINE | Alu | Name=AluJr |
Top |
RNA A-to-I editing events in the alternative splicing sites for PPM1L |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for PPM1L |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for PPM1L |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for PPM1L |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1035699 | chr3_161073082_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-204-3p | chr3 | 161073075 | 161073082 | 8mer-1a | 161073063 | 161073082 | 147 | -19.03 |
| ADediting_1035699 | chr3_161073082_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-326 | chr3 | 161073077 | 161073083 | 7mer-m8 | 161073065 | 161073084 | 140 | -13.25 |
| ADediting_1035699 | chr3_161073082_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-330-5p | chr3 | 161073077 | 161073083 | 7mer-m8 | 161073059 | 161073084 | 145 | -18.18 |
| ADediting_1035699 | chr3_161073082_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-4314 | chr3 | 161073076 | 161073082 | 7mer-m8 | 161073064 | 161073083 | 154 | -22.8 |
| ADediting_1035699 | chr3_161073082_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-4646-5p | chr3 | 161073075 | 161073082 | 8mer-1a | 161073061 | 161073082 | 141 | -19.58 |
| ADediting_1035699 | chr3_161073082_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-514a-5p | chr3 | 161073078 | 161073084 | 7mer-m8 | 161073063 | 161073085 | 146 | -17.81 |
| ADediting_1035700 | chr3_161073083_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-1228-3p | chr3 | 161073081 | 161073087 | 7mer-m8 | 161073069 | 161073088 | 140 | -14.46 |
| ADediting_1035700 | chr3_161073083_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-3189-3p | chr3 | 161073077 | 161073083 | 7mer-m8 | 161073064 | 161073084 | 147 | -18.69 |
| ADediting_1035700 | chr3_161073083_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-6813-3p | chr3 | 161073078 | 161073084 | 7mer-m8 | 161073065 | 161073085 | 140 | -10.68 |
| ADediting_1035702 | chr3_161073655_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-1247-3p | chr3 | 161073650 | 161073656 | 7mer-m8 | 161073635 | 161073657 | 152 | -26.23 |
| ADediting_1035704 | chr3_161073701_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-17-3p | chr3 | 161073697 | 161073703 | 7mer-m8 | 161073683 | 161073704 | 142 | -20.77 |
| ADediting_1035706 | chr3_161073768_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-3190-5p | chr3 | 161073766 | 161073772 | 7mer-m8 | 161073754 | 161073773 | 147 | -18.34 |
| ADediting_1035706 | chr3_161073768_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-548s | chr3 | 161073765 | 161073771 | 7mer-m8 | 161073751 | 161073772 | 143 | -12.53 |
| ADediting_1035707 | chr3_161073823_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-3189-3p | chr3 | 161073817 | 161073823 | 7mer-m8 | 161073805 | 161073824 | 141 | -18.93 |
| ADediting_1035707 | chr3_161073823_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-6813-3p | chr3 | 161073818 | 161073824 | 7mer-m8 | 161073805 | 161073825 | 140 | -12.52 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1035699 | chr3_161073082_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-450a-1-3p | chr3 | 161073075 | 161073082 | 8mer-1a | 161073062 | 161073082 | 152 | -11.95 |
| ADediting_1035700 | chr3_161073083_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-216b-3p | chr3 | 161073081 | 161073087 | 7mer-m8 | 161073062 | 161073088 | 143 | -16.9 |
| ADediting_1035702 | chr3_161073655_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-3689a-3p | chr3 | 161073648 | 161073654 | 7mer-m8 | 161073635 | 161073655 | 150 | -24.97 |
| ADediting_1035702 | chr3_161073655_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-490-3p | chr3 | 161073652 | 161073658 | 7mer-m8 | 161073637 | 161073659 | 146 | -17.97 |
| ADediting_1035702 | chr3_161073655_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-6780a-5p | chr3 | 161073648 | 161073654 | 7mer-m8 | 161073631 | 161073655 | 147 | -22.71 |
| ADediting_1035704 | chr3_161073701_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-20b-3p | chr3 | 161073697 | 161073703 | 7mer-m8 | 161073683 | 161073704 | 151 | -15.85 |
| ADediting_1035706 | chr3_161073768_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-4794 | chr3 | 161073766 | 161073772 | 7mer-m8 | 161073751 | 161073773 | 151 | -18.19 |
| ADediting_1035706 | chr3_161073768_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-664a-5p | chr3 | 161073766 | 161073772 | 7mer-m8 | 161073750 | 161073773 | 141 | -15.8 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-589-3p | chr3 | 161072072 | 161072078 | 7mer-m8 | 161072057 | 161072079 | 143 | -13.26 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-589-3p | chr3 | 161076299 | 161076305 | 7mer-m8 | 161076279 | 161076306 | 142 | -12.15 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-4477b | chr3 | 161075890 | 161075896 | 7mer-m8 | 161075876 | 161075897 | 156 | -11.38 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-4477b | chr3 | 161071870 | 161071876 | 7mer-m8 | 161071856 | 161071877 | 146 | -11.12 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-337-3p | chr3 | 161078416 | 161078422 | 7mer-m8 | 161078405 | 161078423 | 147 | -12 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-381-3p | chr3 | 161074931 | 161074937 | 7mer-m8 | 161074916 | 161074938 | 149 | -14.31 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000163590.14 | ENST00000464260.5 | PPM1L-202 | hsa-miR-381-3p | chr3 | 161070539 | 161070545 | 7mer-m8 | 161070525 | 161070546 | 142 | -12.09 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-381-3p | chr3 | 161070539 | 161070545 | 7mer-m8 | 161070525 | 161070546 | 142 | -12.09 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-381-3p | chr3 | 161072223 | 161072229 | 7mer-m8 | 161072209 | 161072230 | 140 | -13.82 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-641 | chr3 | 161073910 | 161073917 | 8mer-1a | 161073894 | 161073917 | 145 | -13.27 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-641 | chr3 | 161076664 | 161076671 | 8mer-1a | 161076644 | 161076671 | 153 | -16.06 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-641 | chr3 | 161078261 | 161078268 | 8mer-1a | 161078246 | 161078268 | 148 | -14.95 |
| ADediting_1596844 | chr1_162342605_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-556-3p | chr3 | 161078436 | 161078442 | 7mer-m8 | 161078422 | 161078443 | 162 | -9.85 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-641 | chr3 | 161073213 | 161073219 | 7mer-m8 | 161073195 | 161073220 | 162 | -20.16 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-4775 | chr3 | 161071686 | 161071692 | 7mer-m8 | 161071672 | 161071693 | 142 | -10.13 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-4775 | chr3 | 161074030 | 161074036 | 7mer-m8 | 161074016 | 161074037 | 158 | -10.29 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-4775 | chr3 | 161074195 | 161074201 | 7mer-1a | 161074177 | 161074201 | 143 | -14.2 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-4775 | chr3 | 161075594 | 161075600 | 7mer-m8 | 161075580 | 161075601 | 146 | -6.99 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-4775 | chr3 | 161078383 | 161078389 | 7mer-m8 | 161078367 | 161078390 | 148 | -7.89 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-4775 | chr3 | 161078503 | 161078510 | 8mer-1a | 161078485 | 161078510 | 150 | -13.63 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-5585-3p | chr3 | 161075430 | 161075437 | 8mer-1a | 161075417 | 161075437 | 148 | -14.03 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-5585-3p | chr3 | 161075917 | 161075923 | 7mer-m8 | 161075898 | 161075924 | 162 | -25.51 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_107020 | chr1_37500952_- | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-5581-3p | chr3 | 161077766 | 161077773 | 8mer-1a | 161077747 | 161077773 | 144 | -14.92 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-5688 | chr3 | 161076509 | 161076515 | 7mer-m8 | 161076496 | 161076516 | 152 | -12.35 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000163590.14 | ENST00000464260.5 | PPM1L-202 | hsa-miR-589-3p | chr3 | 161070201 | 161070208 | 8mer-1a | 161070186 | 161070208 | 150 | -18.79 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-589-3p | chr3 | 161070201 | 161070208 | 8mer-1a | 161070186 | 161070208 | 150 | -18.79 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-337-3p | chr3 | 161072817 | 161072824 | 8mer-1a | 161072803 | 161072824 | 140 | -7.46 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-337-3p | chr3 | 161073125 | 161073131 | 7mer-m8 | 161073108 | 161073132 | 147 | -10.95 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000163590.14 | ENST00000464260.5 | PPM1L-202 | hsa-miR-381-3p | chr3 | 161070944 | 161070950 | 7mer-1a | 161070926 | 161070950 | 150 | -18.85 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-381-3p | chr3 | 161070944 | 161070950 | 7mer-1a | 161070926 | 161070950 | 150 | -18.85 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-381-3p | chr3 | 161072380 | 161072387 | 8mer-1a | 161072365 | 161072387 | 149 | -15.42 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-381-3p | chr3 | 161076218 | 161076224 | 7mer-1a | 161076203 | 161076224 | 140 | -12.56 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-381-3p | chr3 | 161078311 | 161078317 | 7mer-1a | 161078296 | 161078317 | 147 | -17.71 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000163590.14 | ENST00000464260.5 | PPM1L-202 | hsa-miR-381-3p | chr3 | 161070944 | 161070950 | 7mer-1a | 161070926 | 161070950 | 150 | -18.85 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-381-3p | chr3 | 161070944 | 161070950 | 7mer-1a | 161070926 | 161070950 | 150 | -18.85 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-381-3p | chr3 | 161072380 | 161072387 | 8mer-1a | 161072365 | 161072387 | 149 | -15.42 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-381-3p | chr3 | 161076218 | 161076224 | 7mer-1a | 161076203 | 161076224 | 140 | -12.56 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-381-3p | chr3 | 161078311 | 161078317 | 7mer-1a | 161078296 | 161078317 | 147 | -17.71 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-641 | chr3 | 161076211 | 161076217 | 7mer-m8 | 161076195 | 161076218 | 140 | -9.99 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-641 | chr3 | 161076211 | 161076217 | 7mer-m8 | 161076195 | 161076218 | 140 | -9.99 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-4775 | chr3 | 161074447 | 161074453 | 7mer-m8 | 161074433 | 161074454 | 149 | -6.04 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-4775 | chr3 | 161075616 | 161075622 | 7mer-m8 | 161075602 | 161075623 | 140 | -8.21 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000163590.14 | ENST00000498165.6 | PPM1L-205 | hsa-miR-4775 | chr3 | 161076159 | 161076166 | 8mer-1a | 161076145 | 161076166 | 152 | -9.37 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for PPM1L |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000498165.6 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1035699 | ENST00000498165.6 | chr3_161073082_+ | 5086 | -3006.70 | -3006.60 | -3023.60 |
| ADediting_1035700 | ENST00000498165.6 | chr3_161073083_+ | 5087 | -3006.30 | -3006.60 | -3023.60 |
| ADediting_1035701 | ENST00000498165.6 | chr3_161073588_+ | 5592 | -3006.60 | -3006.60 | -3023.60 |
| ADediting_1035702 | ENST00000498165.6 | chr3_161073655_+ | 5659 | -3008.00 | -3006.60 | -3023.60 |
| ADediting_1035703 | ENST00000498165.6 | chr3_161073663_+ | 5667 | -3006.60 | -3006.60 | -3023.60 |
| ADediting_1035704 | ENST00000498165.6 | chr3_161073701_+ | 5705 | -3010.70 | -3006.60 | -3023.60 |
| ADediting_1035705 | ENST00000498165.6 | chr3_161073743_+ | 5747 | -3011.00 | -3006.60 | -3023.60 |
| ADediting_1035706 | ENST00000498165.6 | chr3_161073768_+ | 5772 | -3006.30 | -3006.60 | -3023.60 |
| ADediting_1035707 | ENST00000498165.6 | chr3_161073823_+ | 5827 | -3010.70 | -3006.60 | -3023.60 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for PPM1L |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_1035594 | chr3_160783453_+ | 0.811008807473891 | 0.013635830317683 | 0.119635182461061 | -0.0885762854887762 | 5.83725921188209e-14 | 0.409440741976661 |
| DLPFC | ADediting_1035600 | chr3_160804011_+ | 0.383740561012672 | 0.0496409201399926 | 0.352924429790141 | -0.0529366302110098 | 4.71686280235211e-09 | 0.324892761091454 |
| DLPFC | ADediting_1035641 | chr3_160872724_+ | 0.491108725757181 | -0.0392503000109273 | 0.0421756200356716 | -0.115477706341329 | 8.78384301713406e-09 | 0.319421822026313 |
| DLPFC | ADediting_1035643 | chr3_160872780_+ | 0.345396302695464 | -0.0537688475824059 | 0.00287175124456315 | -0.168782988711944 | 3.67339518574497e-15 | 0.42689902720756 |
| DLPFC | ADediting_1035645 | chr3_160872839_+ | 0.092835089518452 | -0.0956207375104387 | 0.00652362182877875 | -0.154196622223695 | 7.39221737802542e-09 | 0.320950520199293 |
| DLPFC | ADediting_1035668 | chr3_160982048_+ | 0.773282163734797 | -0.0164273505376452 | 0.132853250236912 | -0.0855505735864066 | 3.68466412494341e-11 | 0.364259835815697 |
| DLPFC | ADediting_1035700 | chr3_161073083_+ | 1.37561160292968e-10 | 0.35410143692677 | 0.000100639583623949 | 0.219078762090375 | 0.010934526787408 | -0.144359369152495 |
| CER | ADediting_1035700 | chr3_161073083_+ | 0.00190381492304358 | 0.251524864192321 | 0.58297983106037 | 0.0451837884554151 | 2.16924844816289e-05 | 0.339241738655114 |
| TCX | ADediting_1035700 | chr3_161073083_+ | 7.53011375670172e-08 | 0.421962208943523 | 0.0173646278808236 | 0.194009668885389 | 0.0840444758335441 | 0.141537971161995 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 4.07742485877592e-31 | 0.595347652451201 | 1.2578816154232e-14 | 0.419253921461289 | 0.466821165819004 | -0.0414781366334015 |
| AC | 8.68799649067276e-22 | 0.557154639933631 | 4.29211458095486e-18 | 0.511815389430132 | 5.47179202629614e-11 | 0.399350079003371 |
| PCC | 2.84644407494444e-21 | 0.61517872852618 | 6.19859030551369e-22 | 0.623144729718795 | 0.281865951062431 | 0.078260780245791 |
| CER | 4.15035677679154e-47 | 0.869153871608 | 2.60954640996183e-31 | 0.775083708832945 | 0.000656048338816827 | 0.275119185175626 |
| TCX | 2.57431866936903e-44 | 0.856316946670421 | 1.04318694311213e-30 | 0.770222093699463 | 0.122422324790645 | -0.126674116370561 |
| FP | 4.10942639278004e-31 | 0.731721272099004 | 1.8175480675596e-34 | 0.757817365019861 | 0.271657081137429 | 0.0828345133524243 |
| IFG | 6.79979634481044e-06 | 0.769880152888487 | 0.000594939767870023 | 0.63837530524909 | 0.748814166019804 | -0.0674193899675096 |
| PG | 2.63558280195403e-47 | 0.824157923579979 | 1.0919630670922e-38 | 0.776069748633186 | 0.147785764287716 | -0.106544222512885 |
| STG | 5.72380182714316e-25 | 0.853854893659355 | 2.566472547138e-22 | 0.828123950287598 | 0.971119767587387 | 0.00401024447415927 |
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Relation with AD stages for PPM1L |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 1.68363193783299e-06 | 0.441928323415985 |
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RelatedDrugs for PPM1L |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPM1L |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| PPM1L | C0028754 | Obesity | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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