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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for ANKAR

check button Gene summary
Gene informationGene symbol

ANKAR

Gene ID

150709

Gene nameankyrin and armadillo repeat containing
Synonyms-
Cytomap

2q32.2

Type of geneprotein-coding
Descriptionankyrin and armadillo repeat-containing protein
Modification date20200313
UniProtAcc

Q7Z5J8,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for ANKAR

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_831530(189675528, +), ADediting_831531(189693842, +), ADediting_831532(189693849, +), ADediting_831533(189693882, +), ADediting_831534(189693984, +), ADediting_831535(189704219, +), ADediting_831536(189706133, +), ADediting_831537(189706162, +), ADediting_831538(189706167, +), ADediting_831539(189706318, +), ADediting_831540(189706327, +), ADediting_831541(189706328, +), ADediting_831542(189706343, +), ADediting_831543(189721011, +), ADediting_831544(189721019, +), ADediting_831545(189721057, +), ADediting_831546(189721062, +), ADediting_831547(189721068, +), ADediting_831548(189721088, +), ADediting_831549(189721105, +), ADediting_831550(189721117, +), ADediting_831551(189721127, +), ADediting_831552(189721133, +), ADediting_831553(189721171, +), ADediting_831554(189721238, +), ADediting_831555(189721260, +), ADediting_831556(189721262, +), ADediting_831557(189721263, +), ADediting_831558(189721266, +), ADediting_831559(189722083, +), ADediting_831560(189722087, +), ADediting_831561(189722090, +), ADediting_831562(189722649, +), ADediting_831563(189722695, +), ADediting_831564(189722762, +), ADediting_831565(189722814, +), ADediting_831566(189725634, +), ADediting_831567(189725650, +), ADediting_831568(189725730, +), ADediting_831569(189725761, +), ADediting_831570(189725787, +), ADediting_831571(189725840, +), ADediting_831572(189726399, +), ADediting_831573(189727408, +), ADediting_831574(189727414, +), ADediting_831575(189727431, +), ADediting_831576(189732465, +), ADediting_831577(189732527, +), ADediting_831578(189732567, +), ADediting_831579(189736817, +), ADediting_831580(189736818, +), ADediting_831581(189736839, +), ADediting_831582(189736840, +), ADediting_831583(189736848, +), ADediting_831584(189736863, +), ADediting_831585(189736891, +), ADediting_831586(189736894, +), ADediting_831587(189736923, +), ADediting_831588(189736943, +), ADediting_831589(189736977, +), ADediting_831590(189736994, +), ADediting_831591(189737023, +), ADediting_831592(189737024, +), ADediting_831593(189737029, +), ADediting_831594(189739744, +), ADediting_831595(189739836, +), ADediting_831596(189744967, +), ADediting_831597(189745123, +), ADediting_1561518(189675478, +), ADediting_1561519(189675531, +), ADediting_1561520(189693878, +), ADediting_1561521(189736895, +), ADediting_1561522(189736897, +), ADediting_1561523(189744933, +), ADediting_1634985(189699875, +),

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RNA editing positional annotations for ANKAR using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_831530chr2_189675528_+intronic
ADediting_831531chr2_189693842_+intronic
ADediting_831532chr2_189693849_+intronic
ADediting_831533chr2_189693882_+intronic
ADediting_831534chr2_189693984_+intronic
ADediting_831535chr2_189704219_+intronic
ADediting_831536chr2_189706133_+intronic
ADediting_831537chr2_189706162_+intronic
ADediting_831538chr2_189706167_+intronic
ADediting_831539chr2_189706318_+intronic
ADediting_831540chr2_189706327_+intronic
ADediting_831541chr2_189706328_+intronic
ADediting_831542chr2_189706343_+intronic
ADediting_831543chr2_189721011_+intronic
ADediting_831544chr2_189721019_+intronic
ADediting_831545chr2_189721057_+intronic
ADediting_831546chr2_189721062_+intronic
ADediting_831547chr2_189721068_+intronic
ADediting_831548chr2_189721088_+intronic
ADediting_831549chr2_189721105_+intronic
ADediting_831550chr2_189721117_+intronic
ADediting_831551chr2_189721127_+intronic
ADediting_831552chr2_189721133_+intronic
ADediting_831553chr2_189721171_+intronic
ADediting_831554chr2_189721238_+intronic
ADediting_831555chr2_189721260_+intronic
ADediting_831556chr2_189721262_+intronic
ADediting_831557chr2_189721263_+intronic
ADediting_831558chr2_189721266_+intronic
ADediting_831559chr2_189722083_+intronic
ADediting_831560chr2_189722087_+intronic
ADediting_831561chr2_189722090_+intronic
ADediting_831562chr2_189722649_+intronic
ADediting_831563chr2_189722695_+intronic
ADediting_831564chr2_189722762_+intronic
ADediting_831565chr2_189722814_+intronic
ADediting_831566chr2_189725634_+intronic
ADediting_831567chr2_189725650_+intronic
ADediting_831568chr2_189725730_+intronic
ADediting_831569chr2_189725761_+intronic
ADediting_831570chr2_189725787_+intronic
ADediting_831571chr2_189725840_+intronic
ADediting_831572chr2_189726399_+intronic
ADediting_831573chr2_189727408_+intronic
ADediting_831574chr2_189727414_+intronic
ADediting_831575chr2_189727431_+intronic
ADediting_831576chr2_189732465_+intronic
ADediting_831577chr2_189732527_+intronic
ADediting_831578chr2_189732567_+intronic
ADediting_831579chr2_189736817_+intronic
ADediting_831580chr2_189736818_+intronic
ADediting_831581chr2_189736839_+intronic
ADediting_831582chr2_189736840_+intronic
ADediting_831583chr2_189736848_+intronic
ADediting_831584chr2_189736863_+intronic
ADediting_831585chr2_189736891_+intronic
ADediting_831586chr2_189736894_+intronic
ADediting_831587chr2_189736923_+intronic
ADediting_831588chr2_189736943_+intronic
ADediting_831589chr2_189736977_+intronic
ADediting_831590chr2_189736994_+intronic
ADediting_831591chr2_189737023_+intronic
ADediting_831592chr2_189737024_+intronic
ADediting_831593chr2_189737029_+intronic
ADediting_831594chr2_189739744_+intronic
ADediting_831595chr2_189739836_+intronic
ADediting_831596chr2_189744967_+intronic
ADediting_831597chr2_189745123_+intronic
ADediting_1561518chr2_189675478_+intronic
ADediting_1561519chr2_189675531_+intronic
ADediting_1561520chr2_189693878_+intronic
ADediting_1561521chr2_189736895_+intronic
ADediting_1561522chr2_189736897_+intronic
ADediting_1561523chr2_189744933_+intronic
ADediting_1634985chr2_189699875_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_831530chr2_189675528_+SINEAluName=AluSp
ADediting_831531chr2_189693842_+SINEAluName=AluSz6
ADediting_831532chr2_189693849_+SINEAluName=AluSz6
ADediting_831533chr2_189693882_+SINEAluName=AluSz6
ADediting_831534chr2_189693984_+SINEAluName=AluSz6
ADediting_831535chr2_189704219_+SINEAluName=AluSx
ADediting_831536chr2_189706133_+SINEAluName=AluSz6
ADediting_831537chr2_189706162_+SINEAluName=AluSz6
ADediting_831538chr2_189706167_+SINEAluName=AluSz6
ADediting_831539chr2_189706318_+SINEAluName=AluSz6
ADediting_831540chr2_189706327_+SINEAluName=AluSz6
ADediting_831541chr2_189706328_+SINEAluName=AluSz6
ADediting_831542chr2_189706343_+SINEAluName=AluSz6
ADediting_831543chr2_189721011_+SINEAluName=AluSg
ADediting_831544chr2_189721019_+SINEAluName=AluSg
ADediting_831545chr2_189721057_+SINEAluName=AluSg
ADediting_831546chr2_189721062_+SINEAluName=AluSg
ADediting_831547chr2_189721068_+SINEAluName=AluSg
ADediting_831548chr2_189721088_+SINEAluName=AluSg
ADediting_831549chr2_189721105_+SINEAluName=AluSg
ADediting_831550chr2_189721117_+SINEAluName=AluSg
ADediting_831551chr2_189721127_+SINEAluName=AluSg
ADediting_831552chr2_189721133_+SINEAluName=AluSg
ADediting_831553chr2_189721171_+SINEAluName=AluSg
ADediting_831554chr2_189721238_+SINEAluName=AluSg
ADediting_831555chr2_189721260_+SINEAluName=AluSg
ADediting_831556chr2_189721262_+SINEAluName=AluSg
ADediting_831557chr2_189721263_+SINEAluName=AluSg
ADediting_831558chr2_189721266_+SINEAluName=AluSg
ADediting_831559chr2_189722083_+SINEAluName=AluSx
ADediting_831560chr2_189722087_+SINEAluName=AluSx
ADediting_831561chr2_189722090_+SINEAluName=AluSx
ADediting_831562chr2_189722649_+SINEAluName=AluSc5
ADediting_831563chr2_189722695_+SINEAluName=AluSc5
ADediting_831564chr2_189722762_+SINEAluName=AluSc5
ADediting_831565chr2_189722814_+SINEAluName=AluSc5
ADediting_831566chr2_189725634_+SINEAluName=AluSz6
ADediting_831567chr2_189725650_+SINEAluName=AluSz6
ADediting_831568chr2_189725730_+SINEAluName=AluSz6
ADediting_831569chr2_189725761_+SINEAluName=AluSz6
ADediting_831570chr2_189725787_+SINEAluName=AluSz6
ADediting_831571chr2_189725840_+SINEAluName=AluSz6
ADediting_831572chr2_189726399_+SINEAluName=FLAM_A
ADediting_831573chr2_189727408_+SINEAluName=AluJb
ADediting_831574chr2_189727414_+SINEAluName=AluJb
ADediting_831575chr2_189727431_+SINEAluName=AluJb
ADediting_831576chr2_189732465_+SINEAluName=AluSx3
ADediting_831577chr2_189732527_+SINEAluName=AluSx3
ADediting_831578chr2_189732567_+SINEAluName=AluSx3
ADediting_831579chr2_189736817_+SINEAluName=AluJb
ADediting_831580chr2_189736818_+SINEAluName=AluJb
ADediting_831581chr2_189736839_+SINEAluName=AluJb
ADediting_831582chr2_189736840_+SINEAluName=AluJb
ADediting_831583chr2_189736848_+SINEAluName=AluJb
ADediting_831584chr2_189736863_+SINEAluName=AluJb
ADediting_831585chr2_189736891_+SINEAluName=AluJb
ADediting_831586chr2_189736894_+SINEAluName=AluJb
ADediting_831587chr2_189736923_+SINEAluName=AluJb
ADediting_831588chr2_189736943_+SINEAluName=AluJb
ADediting_831589chr2_189736977_+SINEAluName=AluJb
ADediting_831590chr2_189736994_+SINEAluName=AluJb
ADediting_831591chr2_189737023_+SINEAluName=AluJb
ADediting_831592chr2_189737024_+SINEAluName=AluJb
ADediting_831593chr2_189737029_+SINEAluName=AluJb
ADediting_831594chr2_189739744_+SINEAluName=AluSc
ADediting_831595chr2_189739836_+SINEAluName=AluSc
ADediting_831596chr2_189744967_+SINEAluName=AluSz
ADediting_831597chr2_189745123_+SINEAluName=AluSz
ADediting_1561518chr2_189675478_+SINEAluName=AluSp
ADediting_1561519chr2_189675531_+SINEAluName=AluSp
ADediting_1561520chr2_189693878_+SINEAluName=AluSz6
ADediting_1561521chr2_189736895_+SINEAluName=AluJb
ADediting_1561522chr2_189736897_+SINEAluName=AluJb
ADediting_1561523chr2_189744933_+SINEAluName=AluSz
ADediting_1634985chr2_189699875_+SINEAluName=AluSz

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RNA A-to-I editing events in the alternative splicing sites for ANKAR

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ANKAR

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for ANKAR

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for ANKAR


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ANKAR

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for ANKAR

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CERADediting_831530chr2_189675528_+0.1189498304466480.127854378708955.01309747876869e-060.3629184956442880.02772989678784230.179755197459479
DLPFCADediting_831544chr2_189721019_+0.0928077025215597-0.09562871882239840.00165334418762901-0.1779894615517264.76126251045806e-120.379364088904544
DLPFCADediting_831548chr2_189721088_+0.16476534525208-0.07909835519567820.00531706630432517-0.1579438427329591.56004561725579e-080.314268390235121
DLPFCADediting_831550chr2_189721117_+0.399041583424002-0.04806464147020320.0270808738169475-0.1255495022069656.08773769610307e-120.377590832068284
DLPFCADediting_831554chr2_189721238_+0.432589784432834-0.04473019549614150.00522464480472022-0.158261499702875.31553239217957e-130.394727325472458
DLPFCADediting_831555chr2_189721260_+0.0701100906511846-0.1030114994622830.00117783945789282-0.1834329261595411.46855642529449e-080.314815249639771
DLPFCADediting_831557chr2_189721263_+0.0728075753678208-0.1020404431411860.00162452212332124-0.1782755356721022.71161561632321e-090.329673864474972
DLPFCADediting_831558chr2_189721266_+0.0912844768620063-0.09607562115327770.0025101708365137-0.1710685399612445.38449605639073e-090.323737072327371
DLPFCADediting_831559chr2_189722083_+0.6118139482845670.02893411179636030.268776475257233-0.06300212098377952.52968395118916e-140.414826613700851
DLPFCADediting_831560chr2_189722087_+0.5646544881496370.03283512290463370.281100227749933-0.06140810911048041.09406795713014e-160.447717371566404
DLPFCADediting_831565chr2_189722814_+0.522999870214962-0.03641237951593870.0205777451970056-0.1314794175725632.21574903857789e-100.350334724350622
DLPFCADediting_831581chr2_189736839_+0.924206014394117-0.005425295290605360.0429420545744591-0.1150537178687672.40387427529211e-170.456273639195027
DLPFCADediting_831582chr2_189736840_+0.779059734384265-0.01599746712885320.124416111538757-0.0874532778667422.19385656860524e-100.350413695614625
DLPFCADediting_831589chr2_189736977_+0.315682214401347-0.05717194134969380.0358406443943613-0.1192559595174321.85888135967553e-110.369398087140798
DLPFCADediting_831592chr2_189737024_+0.187668010426172-0.07502707689470890.0299985269130923-0.1232814499674969.46597485718319e-100.338541805805238

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC3.46822413886766e-080.3069328784320399.25760254752478e-050.2201900054816610.07800370358386510.100249614604874
PCC0.03358667704291940.1538528197593960.2240502268545490.08838216715018429.86043928095289e-090.400008797360387
CER4.49295903643927e-270.738105726665339.82498337003307e-240.7037519436472890.02575120444512450.182072566700359
TCX3.1640594873986e-170.6188820150192720.01787160798925650.1931593808458218.28621164574973e-130.541586593058068
FP1.21754035487869e-170.5837186229974582.23264668802348e-190.6080553925777257.55472807862943e-060.328548472538631
IFG0.01250432375424820.4919032633900360.003323323316672840.5639508139502720.001759777422972310.593597146818203
PG1.51473772712735e-300.7161048574400581.13025313505202e-180.5878740351712940.6525982738959570.0332218521773449
STG2.39163489717739e-080.5635330421224297.41887638011146e-080.5467592542187890.002025825001123220.332118664660432

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Relation with AD stages for ANKAR

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER0.0001990228193940430.350627273349
TCX1.42459705388382e-100.572608848670177

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RelatedDrugs for ANKAR

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANKAR

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource