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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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Gene summary for CHADL |
 Gene summary |
| Gene information | Gene symbol | CHADL | Gene ID | 150356 |
| Gene name | chondroadherin like | |
| Synonyms | SLRR4B | |
| Cytomap | 22q13.2 | |
| Type of gene | protein-coding | |
| Description | chondroadherin-like protein | |
| Modification date | 20200313 | |
| UniProtAcc | Q6NUI6, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CHADL | GO:1904027 | negative regulation of collagen fibril organization | 25451920 |
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RNA A-to-I events for CHADL |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_998067(41232076, -), ADediting_998068(41232089, -), ADediting_998069(41232232, -), ADediting_998070(41232249, -), ADediting_998071(41233279, -), ADediting_998072(41233345, -), ADediting_998073(41233350, -), ADediting_998074(41233362, -), ADediting_998075(41233379, -), ADediting_998076(41234444, -), ADediting_998077(41234646, -), ADediting_998078(41234651, -), ADediting_998079(41234659, -), ADediting_998080(41234665, -), ADediting_998081(41234682, -), ADediting_998082(41234692, -), ADediting_998083(41234749, -), ADediting_998084(41234759, -), ADediting_998085(41234760, -), ADediting_998086(41234775, -), ADediting_998087(41234795, -), ADediting_998088(41234825, -), ADediting_998089(41234834, -), ADediting_998090(41234884, -), ADediting_998091(41234894, -), ADediting_998092(41234910, -), ADediting_998093(41234917, -), ADediting_998094(41234948, -), ADediting_1570958(41234611, -), ADediting_1570959(41234626, -), ADediting_1570960(41234669, -), ADediting_1570961(41234718, -), ADediting_1570962(41234725, -), ADediting_1570963(41234782, -), |
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RNA editing positional annotations for CHADL using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_998067 | chr22_41232076_- | intronic |
| ADediting_998068 | chr22_41232089_- | intronic |
| ADediting_998069 | chr22_41232232_- | intronic |
| ADediting_998070 | chr22_41232249_- | intronic |
| ADediting_998071 | chr22_41233279_- | intronic |
| ADediting_998072 | chr22_41233345_- | intronic |
| ADediting_998073 | chr22_41233350_- | intronic |
| ADediting_998074 | chr22_41233362_- | intronic |
| ADediting_998075 | chr22_41233379_- | intronic |
| ADediting_998076 | chr22_41234444_- | intronic |
| ADediting_998077 | chr22_41234646_- | intronic |
| ADediting_998078 | chr22_41234651_- | intronic |
| ADediting_998079 | chr22_41234659_- | intronic |
| ADediting_998080 | chr22_41234665_- | intronic |
| ADediting_998081 | chr22_41234682_- | intronic |
| ADediting_998082 | chr22_41234692_- | intronic |
| ADediting_998083 | chr22_41234749_- | intronic |
| ADediting_998084 | chr22_41234759_- | intronic |
| ADediting_998085 | chr22_41234760_- | intronic |
| ADediting_998086 | chr22_41234775_- | intronic |
| ADediting_998087 | chr22_41234795_- | intronic |
| ADediting_998088 | chr22_41234825_- | intronic |
| ADediting_998089 | chr22_41234834_- | intronic |
| ADediting_998090 | chr22_41234884_- | intronic |
| ADediting_998091 | chr22_41234894_- | intronic |
| ADediting_998092 | chr22_41234910_- | intronic |
| ADediting_998093 | chr22_41234917_- | intronic |
| ADediting_998094 | chr22_41234948_- | intronic |
| ADediting_1570958 | chr22_41234611_- | intronic |
| ADediting_1570959 | chr22_41234626_- | intronic |
| ADediting_1570960 | chr22_41234669_- | intronic |
| ADediting_1570961 | chr22_41234718_- | intronic |
| ADediting_1570962 | chr22_41234725_- | intronic |
| ADediting_1570963 | chr22_41234782_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_998067 | chr22_41232076_- | SINE | Alu | Name=AluSc8 |
| ADediting_998068 | chr22_41232089_- | SINE | Alu | Name=AluSc8 |
| ADediting_998069 | chr22_41232232_- | SINE | Alu | Name=AluSc8 |
| ADediting_998070 | chr22_41232249_- | SINE | Alu | Name=AluSc8 |
| ADediting_998071 | chr22_41233279_- | SINE | Alu | Name=AluSq2 |
| ADediting_998072 | chr22_41233345_- | SINE | Alu | Name=AluSq2 |
| ADediting_998073 | chr22_41233350_- | SINE | Alu | Name=AluSq2 |
| ADediting_998074 | chr22_41233362_- | SINE | Alu | Name=AluSq2 |
| ADediting_998075 | chr22_41233379_- | SINE | Alu | Name=AluSq2 |
| ADediting_998076 | chr22_41234444_- | SINE | Alu | Name=AluSc |
| ADediting_998077 | chr22_41234646_- | SINE | Alu | Name=AluY |
| ADediting_998078 | chr22_41234651_- | SINE | Alu | Name=AluY |
| ADediting_998079 | chr22_41234659_- | SINE | Alu | Name=AluY |
| ADediting_998080 | chr22_41234665_- | SINE | Alu | Name=AluY |
| ADediting_998081 | chr22_41234682_- | SINE | Alu | Name=AluY |
| ADediting_998082 | chr22_41234692_- | SINE | Alu | Name=AluY |
| ADediting_998083 | chr22_41234749_- | SINE | Alu | Name=AluY |
| ADediting_998084 | chr22_41234759_- | SINE | Alu | Name=AluY |
| ADediting_998085 | chr22_41234760_- | SINE | Alu | Name=AluY |
| ADediting_998086 | chr22_41234775_- | SINE | Alu | Name=AluY |
| ADediting_998087 | chr22_41234795_- | SINE | Alu | Name=AluY |
| ADediting_998088 | chr22_41234825_- | SINE | Alu | Name=AluY |
| ADediting_998089 | chr22_41234834_- | SINE | Alu | Name=AluY |
| ADediting_998090 | chr22_41234884_- | SINE | Alu | Name=AluSc |
| ADediting_998091 | chr22_41234894_- | SINE | Alu | Name=AluSc |
| ADediting_998092 | chr22_41234910_- | SINE | Alu | Name=AluSc |
| ADediting_998093 | chr22_41234917_- | SINE | Alu | Name=AluSc |
| ADediting_998094 | chr22_41234948_- | SINE | Alu | Name=AluSc |
| ADediting_1570958 | chr22_41234611_- | SINE | Alu | Name=AluY |
| ADediting_1570959 | chr22_41234626_- | SINE | Alu | Name=AluY |
| ADediting_1570960 | chr22_41234669_- | SINE | Alu | Name=AluY |
| ADediting_1570961 | chr22_41234718_- | SINE | Alu | Name=AluY |
| ADediting_1570962 | chr22_41234725_- | SINE | Alu | Name=AluY |
| ADediting_1570963 | chr22_41234782_- | SINE | Alu | Name=AluY |
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RNA A-to-I editing events in the alternative splicing sites for CHADL |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CHADL |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for CHADL |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for CHADL |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for CHADL |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for CHADL |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| TCX | ADediting_998069 | chr22_41232232_- | 0.718525950353825 | 0.0296706752532805 | 0.00510496445287432 | -0.227542629550989 | 3.36001136790357e-10 | 0.484435426507225 |
| TCX | ADediting_998071 | chr22_41233279_- | 0.501863863304863 | -0.0552529507641681 | 0.000781677481443315 | -0.271382085222105 | 3.19535939588935e-08 | 0.432734878291514 |
| DLPFC | ADediting_998072 | chr22_41233345_- | 0.14918478508813 | 0.0821170936258997 | 0.666496254482487 | -0.024572547742234 | 3.5900357573694e-10 | 0.346470022273828 |
| TCX | ADediting_998072 | chr22_41233345_- | 0.872847109622545 | 0.0131771314564503 | 0.00667688825779041 | -0.220588583113795 | 1.5505209734326e-08 | 0.441539464534521 |
| DLPFC | ADediting_998073 | chr22_41233350_- | 0.321023047073769 | 0.0565454551024018 | 0.71782761550044 | -0.0206051368281134 | 1.50747268768249e-09 | 0.334655739741992 |
| TCX | ADediting_998073 | chr22_41233350_- | 0.331112517755001 | -0.0798947173302536 | 3.83388257272652e-05 | -0.329493419757596 | 6.4833985422525e-08 | 0.423870343368279 |
| TCX | ADediting_998074 | chr22_41233362_- | 0.952870676984243 | 0.00486635836551624 | 0.0129131166703705 | -0.202579191672502 | 8.08192165419439e-07 | 0.390004034356458 |
| DLPFC | ADediting_998075 | chr22_41233379_- | 0.0784392313087892 | 0.100103953665778 | 0.30527973441776 | 0.0584123763640218 | 5.28682495911522e-08 | 0.302979567771101 |
| DLPFC | ADediting_998078 | chr22_41234651_- | 0.0405871100595 | 0.116377543393343 | 0.85493622328392 | -0.0104255321546081 | 6.30498478672791e-24 | 0.530757552994717 |
| TCX | ADediting_998078 | chr22_41234651_- | 0.445432557956828 | -0.0627665163817345 | 0.000229671840198695 | -0.296479588730474 | 1.00123040228701e-08 | 0.446745922946156 |
| TCX | ADediting_998079 | chr22_41234659_- | 0.641902163730496 | -0.038276713236505 | 0.000284083008095515 | -0.292286063261828 | 1.18427025544745e-09 | 0.470975691080115 |
| DLPFC | ADediting_998081 | chr22_41234682_- | 0.127145826070905 | 0.0868270441878211 | 0.904797432647893 | 0.00682048312336439 | 1.16470176500477e-11 | 0.372857371152983 |
| TCX | ADediting_998081 | chr22_41234682_- | 0.812834805722046 | -0.0194934686359018 | 0.000797461166382174 | -0.270952318536171 | 3.19847177893143e-08 | 0.432722853905115 |
| DLPFC | ADediting_998082 | chr22_41234692_- | 0.0274001036961986 | 0.125291407671944 | 0.493980103912693 | 0.038990883551524 | 1.59559242015294e-12 | 0.387124999098093 |
| TCX | ADediting_998082 | chr22_41234692_- | 0.43793483917949 | -0.0638036159791298 | 0.000217128637341726 | -0.297576699172443 | 1.11261366214302e-06 | 0.385432076675733 |
| DLPFC | ADediting_998083 | chr22_41234749_- | 0.0308384646186035 | 0.122663604465972 | 0.622992170799683 | 0.0280295505838803 | 3.05356838601117e-08 | 0.308115505943356 |
| TCX | ADediting_998083 | chr22_41234749_- | 0.232678814986265 | -0.0980329544390888 | 0.000561740726243782 | -0.278386125816849 | 0.000123453637759226 | 0.30837179435912 |
| TCX | ADediting_998084 | chr22_41234759_- | 0.682185208545023 | 0.0337066181815109 | 0.00221160004960033 | -0.248026083503758 | 2.42094805426683e-07 | 0.406652593278164 |
| DLPFC | ADediting_998087 | chr22_41234795_- | 0.0387789211588672 | 0.117438725269284 | 0.354182975658966 | 0.052798596655623 | 6.76341117095739e-10 | 0.341316184420796 |
| TCX | ADediting_998087 | chr22_41234795_- | 0.895089121062191 | -0.0108574440717578 | 0.00307421120203163 | -0.240162179881775 | 2.61018179446198e-08 | 0.435223153535859 |
| DLPFC | ADediting_998089 | chr22_41234834_- | 0.041255599502485 | 0.115995312088371 | 0.798120708995499 | -0.0145854774406752 | 3.28718020041976e-08 | 0.307431456447987 |
| TCX | ADediting_998089 | chr22_41234834_- | 0.285720318811094 | -0.0877313964998898 | 0.00028086873661972 | -0.292512129969073 | 4.9949460864016e-08 | 0.427167681109938 |
| TCX | ADediting_998092 | chr22_41234910_- | 0.45186280276031 | 0.0618848933385785 | 0.0449341014209693 | -0.163991357694388 | 5.24416604527277e-08 | 0.426554799214462 |
| DLPFC | ADediting_998093 | chr22_41234917_- | 0.107535830064688 | 0.0915837625130702 | 0.892653432962995 | 0.00769547378345105 | 6.54058595127582e-13 | 0.393307808177481 |
| TCX | ADediting_998093 | chr22_41234917_- | 0.639769112484824 | 0.0385218709593636 | 0.0369478756878727 | -0.170525674954439 | 8.67015034458072e-07 | 0.389005100089822 |
| DLPFC | ADediting_998094 | chr22_41234948_- | 0.189296092127716 | 0.0747519543137611 | 0.943655904855315 | -0.00403037233550894 | 7.51274305436277e-11 | 0.358810666665218 |
| TCX | ADediting_998094 | chr22_41234948_- | 0.707492999682886 | 0.0308880888754805 | 0.040928575053807 | -0.167134771688602 | 9.37153156562567e-05 | 0.313493362814618 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 0.00014037849139656 | 0.214593806248945 | 0.0438592526775988 | 0.114554614522088 | 1.63969206245504e-71 | 0.804014413844092 |
| AC | 3.95501451522599e-29 | 0.630648290312257 | 1.33696161761074e-20 | 0.543313760372351 | 7.30753314221186e-39 | 0.704883388947373 |
| PCC | 0.0148008284837979 | 0.176126108282835 | 0.0595036305120666 | 0.136611081266721 | 8.43549330547374e-12 | 0.468265009768376 |
| CER | 0.00910772674955583 | -0.212284137051653 | 2.6377200299899e-06 | -0.372729325947172 | 0.632388240640498 | 0.0393728115537926 |
| TCX | 0.557501888947133 | 0.048267959293165 | 5.03739819955558e-05 | -0.324700646833797 | 2.72547981517339e-18 | 0.634763263784425 |
| FP | 0.000441381288408511 | 0.260655352937128 | 0.00548782080353598 | 0.207332415219562 | 1.47998200195921e-21 | 0.635892855497357 |
| IFG | 0.509285063440851 | 0.138440013119819 | 0.70361480378047 | -0.0800658073301272 | 0.000265477613493701 | 0.667712241221006 |
| PG | 0.00391705573946343 | -0.210564030201945 | 6.32554929311586e-05 | -0.288983293247934 | 1.35385384086981e-25 | 0.670017088963783 |
| STG | 0.0014429770374451 | 0.342181779148117 | 0.337953848427888 | 0.105841812605542 | 3.65283951007587e-12 | 0.668614322073206 |
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Relation with AD stages for CHADL |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for CHADL |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CHADL |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| CHADL | C0029410 | Osteoarthritis of hip | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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