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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for BTBD19 |
 Gene summary |
| Gene information | Gene symbol | BTBD19 | Gene ID | 149478 |
| Gene name | BTB domain containing 19 | |
| Synonyms | - | |
| Cytomap | 1p34.1 | |
| Type of gene | protein-coding | |
| Description | BTB/POZ domain-containing protein 19BTB (POZ) domain containing 19novel BTB domain containing protein | |
| Modification date | 20200313 | |
| UniProtAcc | C9JJ37, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for BTBD19 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_116828(44814378, +), ADediting_116829(44814427, +), ADediting_116830(44814437, +), ADediting_116831(44814505, +), ADediting_116832(44814509, +), ADediting_116833(44814627, +), ADediting_116834(44814653, +), ADediting_116835(44814670, +), ADediting_116836(44814692, +), ADediting_116837(44814694, +), ADediting_116838(44814702, +), ADediting_116839(44814708, +), ADediting_116840(44814718, +), ADediting_116841(44814719, +), ADediting_116842(44814727, +), ADediting_116843(44814733, +), ADediting_116844(44814736, +), ADediting_116845(44814751, +), ADediting_116846(44814754, +), ADediting_116847(44814763, +), ADediting_116848(44814800, +), ADediting_116849(44814828, +), |
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RNA editing positional annotations for BTBD19 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_116828 | chr1_44814378_+ | downstream |
| ADediting_116829 | chr1_44814427_+ | downstream |
| ADediting_116830 | chr1_44814437_+ | downstream |
| ADediting_116831 | chr1_44814505_+ | downstream |
| ADediting_116832 | chr1_44814509_+ | downstream |
| ADediting_116833 | chr1_44814627_+ | downstream |
| ADediting_116834 | chr1_44814653_+ | downstream |
| ADediting_116835 | chr1_44814670_+ | downstream |
| ADediting_116836 | chr1_44814692_+ | downstream |
| ADediting_116837 | chr1_44814694_+ | downstream |
| ADediting_116838 | chr1_44814702_+ | downstream |
| ADediting_116839 | chr1_44814708_+ | downstream |
| ADediting_116840 | chr1_44814718_+ | downstream |
| ADediting_116841 | chr1_44814719_+ | downstream |
| ADediting_116842 | chr1_44814727_+ | downstream |
| ADediting_116843 | chr1_44814733_+ | downstream |
| ADediting_116844 | chr1_44814736_+ | downstream |
| ADediting_116845 | chr1_44814751_+ | downstream |
| ADediting_116846 | chr1_44814754_+ | downstream |
| ADediting_116847 | chr1_44814763_+ | downstream |
| ADediting_116848 | chr1_44814800_+ | downstream |
| ADediting_116849 | chr1_44814828_+ | downstream |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_116828 | chr1_44814378_+ | SINE | Alu | Name=AluYk3 |
| ADediting_116829 | chr1_44814427_+ | SINE | Alu | Name=AluYk3 |
| ADediting_116830 | chr1_44814437_+ | SINE | Alu | Name=AluYk3 |
| ADediting_116831 | chr1_44814505_+ | SINE | Alu | Name=AluYk3 |
| ADediting_116832 | chr1_44814509_+ | SINE | Alu | Name=AluYk3 |
| ADediting_116833 | chr1_44814627_+ | SINE | Alu | Name=AluSx |
| ADediting_116834 | chr1_44814653_+ | SINE | Alu | Name=AluSx |
| ADediting_116835 | chr1_44814670_+ | SINE | Alu | Name=AluSx |
| ADediting_116836 | chr1_44814692_+ | SINE | Alu | Name=AluSx |
| ADediting_116837 | chr1_44814694_+ | SINE | Alu | Name=AluSx |
| ADediting_116838 | chr1_44814702_+ | SINE | Alu | Name=AluSx |
| ADediting_116839 | chr1_44814708_+ | SINE | Alu | Name=AluSx |
| ADediting_116840 | chr1_44814718_+ | SINE | Alu | Name=AluSx |
| ADediting_116841 | chr1_44814719_+ | SINE | Alu | Name=AluSx |
| ADediting_116842 | chr1_44814727_+ | SINE | Alu | Name=AluSx |
| ADediting_116843 | chr1_44814733_+ | SINE | Alu | Name=AluSx |
| ADediting_116844 | chr1_44814736_+ | SINE | Alu | Name=AluSx |
| ADediting_116845 | chr1_44814751_+ | SINE | Alu | Name=AluSx |
| ADediting_116846 | chr1_44814754_+ | SINE | Alu | Name=AluSx |
| ADediting_116847 | chr1_44814763_+ | SINE | Alu | Name=AluSx |
| ADediting_116848 | chr1_44814800_+ | SINE | Alu | Name=AluSx |
| ADediting_116849 | chr1_44814828_+ | SINE | Alu | Name=AluSx |
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RNA A-to-I editing events in the alternative splicing sites for BTBD19 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for BTBD19 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for BTBD19 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for BTBD19 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_291761 | chr11_93733708_- | ENSG00000222009.8 | ENST00000409335.6 | BTBD19-201 | hsa-miR-1304-3p | chr1 | 44813882 | 44813888 | 7mer-m8 | 44813865 | 44813889 | 145 | -15.39 |
| ADediting_291761 | chr11_93733708_- | ENSG00000222009.8 | ENST00000450269.5 | BTBD19-203 | hsa-miR-1304-3p | chr1 | 44813882 | 44813888 | 7mer-m8 | 44813865 | 44813889 | 145 | -15.39 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for BTBD19 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for BTBD19 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_116831 | chr1_44814505_+ | 1.37679396745825e-05 | 0.244162234265456 | 0.0749179341111713 | 0.101300973843525 | 8.20205241523231e-15 | 0.421931951803839 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 4.70098404644099e-08 | 0.304086825090352 | 0.0130089050491385 | 0.140919478905874 | 3.29056776801937e-55 | 0.741001154913749 |
| TCX | 7.88244006586289e-05 | 0.316662037856064 | 0.505511557630201 | 0.0547832802988947 | 4.58127044768581e-07 | 0.397957039801277 |
| FP | 2.98739298825279e-06 | 0.341952780306167 | 0.0231693828370714 | 0.170146743302174 | 1.3108473652155e-08 | 0.410081446731279 |
| IFG | 0.00121210343336453 | 0.609755809174823 | 0.000156288237428302 | 0.685392545911745 | 0.0021895303336631 | 0.583719145818631 |
| PG | 0.583715669942098 | 0.0404349181415766 | 0.231178527124916 | 0.0882158109865776 | 1.66601947188039e-05 | 0.309973867789835 |
| STG | 0.580070480081105 | 0.0612287481952646 | 0.128343246402038 | -0.167253443967042 | 0.00061026049322264 | 0.366319709205897 |
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Relation with AD stages for BTBD19 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 2.44335159255311e-06 | 0.439447559863979 |
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RelatedDrugs for BTBD19 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BTBD19 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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