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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for EXOC8 |
 Gene summary |
| Gene information | Gene symbol | EXOC8 | Gene ID | 149371 |
| Gene name | exocyst complex component 8 | |
| Synonyms | EXO84|Exo84p|SEC84 | |
| Cytomap | 1q42.2 | |
| Type of gene | protein-coding | |
| Description | exocyst complex component 8exocyst complex 84 kDa subunit | |
| Modification date | 20200313 | |
| UniProtAcc | Q8IYI6, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| EXOC8 | GO:0006887 | exocytosis | 14525976 |
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RNA A-to-I events for EXOC8 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_73248(231335074, -), ADediting_73249(231335096, -), ADediting_73250(231335100, -), ADediting_73251(231335116, -), ADediting_73252(231335118, -), ADediting_73253(231335125, -), ADediting_73254(231335128, -), ADediting_73255(231335140, -), ADediting_73256(231335145, -), ADediting_73257(231335154, -), ADediting_73258(231335158, -), ADediting_73259(231335183, -), ADediting_73260(231335194, -), ADediting_73261(231335202, -), ADediting_73262(231335226, -), ADediting_1517954(231335043, -), |
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RNA editing positional annotations for EXOC8 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_73248 | chr1_231335074_- | UTR3 |
| ADediting_73249 | chr1_231335096_- | UTR3 |
| ADediting_73250 | chr1_231335100_- | UTR3 |
| ADediting_73251 | chr1_231335116_- | UTR3 |
| ADediting_73252 | chr1_231335118_- | UTR3 |
| ADediting_73253 | chr1_231335125_- | UTR3 |
| ADediting_73254 | chr1_231335128_- | UTR3 |
| ADediting_73255 | chr1_231335140_- | UTR3 |
| ADediting_73256 | chr1_231335145_- | UTR3 |
| ADediting_73257 | chr1_231335154_- | UTR3 |
| ADediting_73258 | chr1_231335158_- | UTR3 |
| ADediting_73259 | chr1_231335183_- | UTR3 |
| ADediting_73260 | chr1_231335194_- | UTR3 |
| ADediting_73261 | chr1_231335202_- | UTR3 |
| ADediting_73262 | chr1_231335226_- | UTR3 |
| ADediting_1517954 | chr1_231335043_- | UTR3 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_73248 | chr1_231335074_- | SINE | Alu | Name=AluJb |
| ADediting_73249 | chr1_231335096_- | SINE | Alu | Name=AluJb |
| ADediting_73250 | chr1_231335100_- | SINE | Alu | Name=AluJb |
| ADediting_73251 | chr1_231335116_- | SINE | Alu | Name=AluJb |
| ADediting_73252 | chr1_231335118_- | SINE | Alu | Name=AluJb |
| ADediting_73253 | chr1_231335125_- | SINE | Alu | Name=AluJb |
| ADediting_73254 | chr1_231335128_- | SINE | Alu | Name=AluJb |
| ADediting_73255 | chr1_231335140_- | SINE | Alu | Name=AluJb |
| ADediting_73256 | chr1_231335145_- | SINE | Alu | Name=AluJb |
| ADediting_73257 | chr1_231335154_- | SINE | Alu | Name=AluJb |
| ADediting_73258 | chr1_231335158_- | SINE | Alu | Name=AluJb |
| ADediting_73259 | chr1_231335183_- | SINE | Alu | Name=AluJb |
| ADediting_73260 | chr1_231335194_- | SINE | Alu | Name=AluJb |
| ADediting_73261 | chr1_231335202_- | SINE | Alu | Name=AluJb |
| ADediting_73262 | chr1_231335226_- | SINE | Alu | Name=AluJb |
| ADediting_1517954 | chr1_231335043_- | SINE | Alu | Name=AluJb |
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RNA A-to-I editing events in the alternative splicing sites for EXOC8 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for EXOC8 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for EXOC8 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for EXOC8 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1517954 | chr1_231335043_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-6849-3p | chr1 | 231335042 | 231335048 | 7mer-m8 | 231335041 | 231335061 | 152 | -18.03 |
| ADediting_73249 | chr1_231335096_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-137-5p | chr1 | 231335096 | 231335102 | 7mer-m8 | 231335095 | 231335115 | 146 | -20.45 |
| ADediting_73250 | chr1_231335100_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-1285-3p | chr1 | 231335095 | 231335101 | 7mer-m8 | 231335094 | 231335115 | 140 | -17.52 |
| ADediting_73250 | chr1_231335100_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-3187-5p | chr1 | 231335095 | 231335101 | 7mer-m8 | 231335094 | 231335117 | 162 | -24.6 |
| ADediting_73250 | chr1_231335100_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-3622b-5p | chr1 | 231335098 | 231335104 | 7mer-m8 | 231335097 | 231335117 | 143 | -19.86 |
| ADediting_73250 | chr1_231335100_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-4253 | chr1 | 231335096 | 231335103 | 8mer-1a | 231335096 | 231335113 | 140 | -14.07 |
| ADediting_73250 | chr1_231335100_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-5189-5p | chr1 | 231335095 | 231335101 | 7mer-m8 | 231335094 | 231335115 | 146 | -20.03 |
| ADediting_73250 | chr1_231335100_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-612 | chr1 | 231335095 | 231335101 | 7mer-m8 | 231335094 | 231335118 | 147 | -25.65 |
| ADediting_73250 | chr1_231335100_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-6860 | chr1 | 231335095 | 231335101 | 7mer-m8 | 231335094 | 231335115 | 156 | -24.54 |
| ADediting_73250 | chr1_231335100_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-6862-5p | chr1 | 231335096 | 231335103 | 8mer-1a | 231335096 | 231335117 | 152 | -18.46 |
| ADediting_73252 | chr1_231335118_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-6070 | chr1 | 231335118 | 231335124 | 7mer-m8 | 231335117 | 231335136 | 152 | -16.13 |
| ADediting_73254 | chr1_231335128_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-3064-3p | chr1 | 231335125 | 231335131 | 7mer-m8 | 231335124 | 231335146 | 141 | -13.52 |
| ADediting_73254 | chr1_231335128_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-4722-3p | chr1 | 231335122 | 231335129 | 8mer-1a | 231335122 | 231335142 | 141 | -16.05 |
| ADediting_73254 | chr1_231335128_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-6727-3p | chr1 | 231335122 | 231335129 | 8mer-1a | 231335122 | 231335141 | 147 | -18.46 |
| ADediting_73254 | chr1_231335128_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-6747-3p | chr1 | 231335122 | 231335128 | 7mer-1a | 231335109 | 231335133 | 143 | -20.62 |
| ADediting_73256 | chr1_231335145_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-6765-5p | chr1 | 231335140 | 231335146 | 7mer-m8 | 231335139 | 231335160 | 153 | -26.5 |
| ADediting_73257 | chr1_231335154_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-6765-3p | chr1 | 231335154 | 231335160 | 7mer-m8 | 231335153 | 231335170 | 148 | -25.09 |
| ADediting_73260 | chr1_231335194_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-1915-5p | chr1 | 231335193 | 231335199 | 7mer-m8 | 231335192 | 231335214 | 154 | -28.84 |
| ADediting_73260 | chr1_231335194_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-3200-3p | chr1 | 231335192 | 231335198 | 7mer-m8 | 231335191 | 231335215 | 158 | -25.61 |
| ADediting_73260 | chr1_231335194_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-769-5p | chr1 | 231335189 | 231335195 | 7mer-m8 | 231335188 | 231335207 | 142 | -19.01 |
| ADediting_73262 | chr1_231335226_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-4649-5p | chr1 | 231335223 | 231335229 | 7mer-m8 | 231335222 | 231335243 | 151 | -24.81 |
| ADediting_73262 | chr1_231335226_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-6729-5p | chr1 | 231335223 | 231335229 | 7mer-m8 | 231335222 | 231335245 | 145 | -21.32 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_73248 | chr1_231335074_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-1283 | chr1 | 231335072 | 231335079 | 8mer-1a | 231335072 | 231335093 | 149 | -11.59 |
| ADediting_73248 | chr1_231335074_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-3675-3p | chr1 | 231335069 | 231335075 | 7mer-m8 | 231335068 | 231335090 | 152 | -12.58 |
| ADediting_73248 | chr1_231335074_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-4684-5p | chr1 | 231335070 | 231335076 | 7mer-m8 | 231335069 | 231335091 | 151 | -11.33 |
| ADediting_73248 | chr1_231335074_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-519a-2-5p | chr1 | 231335070 | 231335077 | 8mer-1a | 231335070 | 231335090 | 153 | -15.12 |
| ADediting_73248 | chr1_231335074_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-520b-5p | chr1 | 231335070 | 231335077 | 8mer-1a | 231335070 | 231335090 | 153 | -15.12 |
| ADediting_73249 | chr1_231335096_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-5589-5p | chr1 | 231335094 | 231335100 | 7mer-m8 | 231335093 | 231335113 | 154 | -21.19 |
| ADediting_73251 | chr1_231335116_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-214-5p | chr1 | 231335112 | 231335118 | 7mer-1a | 231335108 | 231335129 | 140 | -22.88 |
| ADediting_73251 | chr1_231335116_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-6514-3p | chr1 | 231335112 | 231335118 | 7mer-m8 | 231335111 | 231335131 | 154 | -21 |
| ADediting_73251 | chr1_231335116_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-6811-3p | chr1 | 231335112 | 231335119 | 8mer-1a | 231335112 | 231335132 | 155 | -21.73 |
| ADediting_73252 | chr1_231335118_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-203a-5p | chr1 | 231335116 | 231335123 | 8mer-1a | 231335116 | 231335140 | 146 | -13.47 |
| ADediting_73252 | chr1_231335118_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-218-1-3p | chr1 | 231335118 | 231335124 | 7mer-m8 | 231335117 | 231335137 | 142 | -18.18 |
| ADediting_73252 | chr1_231335118_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-6811-3p | chr1 | 231335112 | 231335119 | 8mer-1a | 231335112 | 231335132 | 155 | -21.73 |
| ADediting_73253 | chr1_231335125_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-3074-5p | chr1 | 231335121 | 231335127 | 7mer-m8 | 231335120 | 231335139 | 151 | -20.49 |
| ADediting_73253 | chr1_231335125_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-370-3p | chr1 | 231335122 | 231335128 | 7mer-1a | 231335122 | 231335143 | 140 | -22.63 |
| ADediting_73254 | chr1_231335128_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-222-3p | chr1 | 231335125 | 231335132 | 8mer-1a | 231335125 | 231335144 | 145 | -16.87 |
| ADediting_73254 | chr1_231335128_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-370-3p | chr1 | 231335122 | 231335128 | 7mer-1a | 231335122 | 231335143 | 140 | -22.63 |
| ADediting_73255 | chr1_231335140_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-4478 | chr1 | 231335136 | 231335142 | 7mer-m8 | 231335135 | 231335151 | 155 | -27.09 |
| ADediting_73255 | chr1_231335140_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-485-5p | chr1 | 231335135 | 231335141 | 7mer-m8 | 231335134 | 231335156 | 151 | -16.49 |
| ADediting_73255 | chr1_231335140_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-7160-5p | chr1 | 231335138 | 231335144 | 7mer-m8 | 231335137 | 231335157 | 150 | -21.7 |
| ADediting_73255 | chr1_231335140_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-7162-3p | chr1 | 231335139 | 231335145 | 7mer-m8 | 231335138 | 231335156 | 152 | -18.02 |
| ADediting_73256 | chr1_231335145_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-1273h-5p | chr1 | 231335145 | 231335151 | 7mer-m8 | 231335144 | 231335163 | 147 | -17.19 |
| ADediting_73256 | chr1_231335145_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-30b-3p | chr1 | 231335145 | 231335151 | 7mer-m8 | 231335144 | 231335165 | 140 | -15.96 |
| ADediting_73256 | chr1_231335145_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-3689a-3p | chr1 | 231335145 | 231335151 | 7mer-m8 | 231335144 | 231335165 | 140 | -20.16 |
| ADediting_73256 | chr1_231335145_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-3689b-3p | chr1 | 231335145 | 231335151 | 7mer-m8 | 231335144 | 231335165 | 140 | -19.99 |
| ADediting_73256 | chr1_231335145_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-3689c | chr1 | 231335145 | 231335151 | 7mer-m8 | 231335144 | 231335165 | 140 | -19.99 |
| ADediting_73256 | chr1_231335145_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-6778-5p | chr1 | 231335144 | 231335150 | 7mer-m8 | 231335143 | 231335164 | 155 | -25.72 |
| ADediting_73256 | chr1_231335145_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-6779-5p | chr1 | 231335145 | 231335151 | 7mer-m8 | 231335144 | 231335167 | 154 | -33.2 |
| ADediting_73256 | chr1_231335145_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-6780a-5p | chr1 | 231335145 | 231335151 | 7mer-m8 | 231335131 | 231335153 | 140 | -19.54 |
| ADediting_73256 | chr1_231335145_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-6780a-5p | chr1 | 231335145 | 231335151 | 7mer-m8 | 231335144 | 231335163 | 147 | -22.79 |
| ADediting_73257 | chr1_231335154_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-4759 | chr1 | 231335149 | 231335155 | 7mer-m8 | 231335148 | 231335168 | 144 | -14.95 |
| ADediting_73258 | chr1_231335158_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-7851-3p | chr1 | 231335154 | 231335161 | 8mer-1a | 231335154 | 231335175 | 152 | -26.68 |
| ADediting_73258 | chr1_231335158_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-939-3p | chr1 | 231335156 | 231335162 | 7mer-m8 | 231335155 | 231335175 | 146 | -19.64 |
| ADediting_73259 | chr1_231335183_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-3174 | chr1 | 231335181 | 231335187 | 7mer-m8 | 231335180 | 231335201 | 153 | -22.94 |
| ADediting_73261 | chr1_231335202_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-324-3p | chr1 | 231335198 | 231335204 | 7mer-m8 | 231335197 | 231335221 | 154 | -25.05 |
| ADediting_73261 | chr1_231335202_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-4252 | chr1 | 231335196 | 231335203 | 8mer-1a | 231335196 | 231335216 | 149 | -22.82 |
| ADediting_73261 | chr1_231335202_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-4793-3p | chr1 | 231335201 | 231335207 | 7mer-m8 | 231335200 | 231335222 | 145 | -20.09 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-4477b | chr1 | 231333236 | 231333243 | 8mer-1a | 231333236 | 231333259 | 153 | -14.54 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-4477b | chr1 | 231334871 | 231334878 | 8mer-1a | 231334871 | 231334894 | 152 | -11.72 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-337-3p | chr1 | 231333390 | 231333396 | 7mer-m8 | 231333389 | 231333410 | 142 | -12.49 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-4775 | chr1 | 231335425 | 231335432 | 8mer-1a | 231335425 | 231335447 | 157 | -8.85 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-5585-3p | chr1 | 231334435 | 231334441 | 7mer-m8 | 231334434 | 231334453 | 147 | -20.25 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1391023 | chr8_140732605_- | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-151a-3p | chr1 | 231332840 | 231332846 | 7mer-m8 | 231332839 | 231332859 | 145 | -11.75 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-381-3p | chr1 | 231332908 | 231332914 | 7mer-m8 | 231332907 | 231332928 | 147 | -10.08 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-381-3p | chr1 | 231332908 | 231332914 | 7mer-m8 | 231332907 | 231332928 | 147 | -10.08 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-4775 | chr1 | 231333873 | 231333879 | 7mer-m8 | 231333872 | 231333895 | 149 | -9.83 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000116903.7 | ENST00000366645.1 | EXOC8-201 | hsa-miR-4775 | chr1 | 231335454 | 231335461 | 8mer-1a | 231335454 | 231335475 | 150 | -6.24 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for EXOC8 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000366645.1 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1517954 | ENST00000366645.1 | chr1_231335043_- | 2810 | -1538.00 | -1534.60 | -1560.70 |
| ADediting_73248 | ENST00000366645.1 | chr1_231335074_- | 2779 | -1536.60 | -1534.60 | -1560.70 |
| ADediting_73249 | ENST00000366645.1 | chr1_231335096_- | 2757 | -1537.60 | -1534.60 | -1560.70 |
| ADediting_73250 | ENST00000366645.1 | chr1_231335100_- | 2753 | -1536.60 | -1534.60 | -1560.70 |
| ADediting_73251 | ENST00000366645.1 | chr1_231335116_- | 2737 | -1535.60 | -1534.60 | -1560.70 |
| ADediting_73252 | ENST00000366645.1 | chr1_231335118_- | 2735 | -1534.50 | -1534.60 | -1560.70 |
| ADediting_73253 | ENST00000366645.1 | chr1_231335125_- | 2728 | -1537.40 | -1534.60 | -1560.70 |
| ADediting_73254 | ENST00000366645.1 | chr1_231335128_- | 2725 | -1540.80 | -1534.60 | -1560.70 |
| ADediting_73255 | ENST00000366645.1 | chr1_231335140_- | 2713 | -1538.60 | -1534.60 | -1560.70 |
| ADediting_73256 | ENST00000366645.1 | chr1_231335145_- | 2708 | -1536.60 | -1534.60 | -1560.70 |
| ADediting_73257 | ENST00000366645.1 | chr1_231335154_- | 2699 | -1541.20 | -1534.60 | -1560.70 |
| ADediting_73258 | ENST00000366645.1 | chr1_231335158_- | 2695 | -1539.00 | -1534.60 | -1560.70 |
| ADediting_73259 | ENST00000366645.1 | chr1_231335183_- | 2670 | -1534.40 | -1534.60 | -1560.70 |
| ADediting_73260 | ENST00000366645.1 | chr1_231335194_- | 2659 | -1536.70 | -1534.60 | -1560.70 |
| ADediting_73261 | ENST00000366645.1 | chr1_231335202_- | 2651 | -1539.20 | -1534.60 | -1560.70 |
| ADediting_73262 | ENST00000366645.1 | chr1_231335226_- | 2627 | -1534.90 | -1534.60 | -1560.70 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for EXOC8 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_73248 | chr1_231335074_- | 0.0115585887243735 | 0.205704075189045 | 7.84300303810914e-07 | 0.390429698914207 | 0.0509885092276106 | 0.15965748424696 |
| CER | ADediting_73249 | chr1_231335096_- | 0.00727561373479705 | 0.218320585001572 | 3.03687068826699e-05 | 0.333522427145141 | 0.273436041326973 | 0.0899926504419115 |
| CER | ADediting_73250 | chr1_231335100_- | 0.00052218563817103 | 0.279909487692874 | 2.73263245568256e-10 | 0.486588958975071 | 0.00315408835573097 | 0.239539175431733 |
| CER | ADediting_73252 | chr1_231335118_- | 0.0244735648954631 | 0.183651232202417 | 5.10012779895128e-08 | 0.42690551862797 | 0.025974840639671 | 0.181803167938902 |
| CER | ADediting_73253 | chr1_231335125_- | 0.000315209879076995 | 0.290211751281471 | 5.24939050774149e-10 | 0.479734889354299 | 0.0748169174611651 | 0.145906896101907 |
| CER | ADediting_73254 | chr1_231335128_- | 0.110214328669283 | 0.130946571919413 | 1.79162501888869e-05 | 0.342443483440968 | 0.068563076653763 | 0.149122415504631 |
| CER | ADediting_73255 | chr1_231335140_- | 0.00636044057172137 | 0.221861425457084 | 2.67585136250407e-07 | 0.405304024928014 | 0.0440944143631502 | 0.164630321129168 |
| CER | ADediting_73256 | chr1_231335145_- | 0.00438487123295782 | 0.231394702526072 | 3.58854889475072e-07 | 0.401315952428049 | 0.100947063441469 | 0.134444192474962 |
| CER | ADediting_73257 | chr1_231335154_- | 0.000628618311614753 | 0.276022261630871 | 4.333040661778e-11 | 0.505143947577473 | 0.00228777414629325 | 0.247228731299426 |
| CER | ADediting_73258 | chr1_231335158_- | 0.00122957108512982 | 0.261467174520817 | 5.67762032801593e-08 | 0.425552532504931 | 0.0244923891978702 | 0.183627465159866 |
| CER | ADediting_73259 | chr1_231335183_- | 0.000152910307855602 | 0.304329718998223 | 1.31754930967752e-10 | 0.494072623978807 | 0.0154488241317828 | 0.197430891893753 |
| CER | ADediting_73260 | chr1_231335194_- | 0.000869703297084924 | 0.269079882518685 | 2.59722222545983e-08 | 0.43528412965623 | 0.00141875631250764 | 0.258254622057822 |
| CER | ADediting_73261 | chr1_231335202_- | 0.000556247631403927 | 0.278591648494671 | 9.57287232474795e-08 | 0.418877211970878 | 0.0110491054334481 | 0.206963215149497 |
| CER | ADediting_73262 | chr1_231335226_- | 0.00204220492115135 | 0.249892557751003 | 6.94336561212783e-06 | 0.357815609208632 | 0.109319928661478 | 0.131273846306964 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.41995385430517e-95 | 0.867843939080496 | 4.40293754710083e-57 | 0.749337948364484 | 0.23497090173113 | 0.0676500385243865 |
| AC | 8.69903398587086e-119 | 0.94110358831604 | 9.45724986186953e-84 | 0.88373462138891 | 1.63283865944711e-06 | 0.297799864570219 |
| PCC | 2.30710559224369e-80 | 0.923085647140188 | 3.32607628224046e-74 | 0.910035075455282 | 0.0598833866742453 | 0.136409822673282 |
| CER | 3.4241607819535e-43 | 0.850770236832934 | 1.85291041333934e-37 | 0.818559036839671 | 0.000108695083943648 | 0.31074937614231 |
| TCX | 7.09810380271044e-60 | 0.914055964264463 | 2.80832017900122e-18 | 0.634574727241884 | 0.0199958763190598 | 0.189809488809305 |
| FP | 1.66731048852889e-19 | 0.609753830249622 | 8.711330278663e-34 | 0.752775027779555 | 0.285778015284002 | 0.080444218935951 |
| IFG | 9.53732952914428e-08 | 0.84669556011277 | 0.000320020253514155 | 0.66118907126532 | 0.862787444308304 | 0.0364185011824629 |
| PG | 1.90860847664545e-50 | 0.838704419455371 | 3.91589591534579e-44 | 0.807964795216013 | 0.214691721129481 | -0.0914030807630038 |
| STG | 7.86134674096498e-20 | 0.799379573284154 | 1.2110113086246e-20 | 0.809324750595994 | 0.809033045138283 | -0.0267650794804166 |
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Relation with AD stages for EXOC8 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_73250 | chr1_231335100_- | 0.000252938865327953 | 0.34523962323118 |
| CER | ADediting_73252 | chr1_231335118_- | 0.000230827279136514 | 0.347306911491548 |
| CER | ADediting_73253 | chr1_231335125_- | 0.000199918203394909 | 0.350527273241987 |
| CER | ADediting_73257 | chr1_231335154_- | 5.06237587072352e-05 | 0.379684453202652 |
| CER | ADediting_73259 | chr1_231335183_- | 5.69372932628165e-05 | 0.377295479366498 |
| CER | ADediting_73260 | chr1_231335194_- | 2.69439936564171e-05 | 0.392196766271466 |
| TCX | ADediting_73252 | chr1_231335118_- | 9.01988146940215e-05 | 0.371042380315196 |
| TCX | ADediting_73259 | chr1_231335183_- | 0.0011466361778202 | 0.311636809513432 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 1.74940354805628e-06 | 0.441292098341697 |
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RelatedDrugs for EXOC8 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EXOC8 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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