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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for CTBP1 |
 Gene summary |
| Gene information | Gene symbol | CTBP1 | Gene ID | 1487 |
| Gene name | C-terminal binding protein 1 | |
| Synonyms | BARS|HADDTS | |
| Cytomap | 4p16.3 | |
| Type of gene | protein-coding | |
| Description | C-terminal-binding protein 1brefeldin A-ribosylated substrate | |
| Modification date | 20200328 | |
| UniProtAcc | Q13363, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for CTBP1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1104719(1219828, -), ADediting_1104720(1219950, -), ADediting_1104721(1220029, -), ADediting_1104722(1220039, -), ADediting_1104806(1229934, -), ADediting_1576213(1219762, -), ADediting_1576214(1219771, -), |
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RNA editing positional annotations for CTBP1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1104719 | chr4_1219828_- | intronic |
| ADediting_1104720 | chr4_1219950_- | intronic |
| ADediting_1104721 | chr4_1220029_- | intronic |
| ADediting_1104722 | chr4_1220039_- | intronic |
| ADediting_1104806 | chr4_1229934_- | intronic |
| ADediting_1576213 | chr4_1219762_- | intronic |
| ADediting_1576214 | chr4_1219771_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1104720 | chr4_1219950_- | SINE | Alu | Name=AluSz6 |
| ADediting_1104721 | chr4_1220029_- | SINE | Alu | Name=AluSz6 |
| ADediting_1104722 | chr4_1220039_- | SINE | Alu | Name=AluSz6 |
| ADediting_1576213 | chr4_1219762_- | SINE | Alu | Name=AluJo |
| ADediting_1576214 | chr4_1219771_- | SINE | Alu | Name=AluJo |
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RNA A-to-I editing events in the alternative splicing sites for CTBP1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CTBP1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for CTBP1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for CTBP1 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000159692.15 | ENST00000510568.1 | CTBP1-209 | hsa-miR-5688 | chr4 | 1236559 | 1236565 | 7mer-m8 | 1236558 | 1236579 | 140 | -12.04 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000159692.15 | ENST00000510568.1 | CTBP1-209 | hsa-miR-5688 | chr4 | 1236594 | 1236600 | 7mer-m8 | 1236593 | 1236615 | 154 | -19.11 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000159692.15 | ENST00000510568.1 | CTBP1-209 | hsa-miR-5688 | chr4 | 1236769 | 1236775 | 7mer-m8 | 1236768 | 1236788 | 148 | -14.1 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000159692.15 | ENST00000510568.1 | CTBP1-209 | hsa-miR-5688 | chr4 | 1236839 | 1236845 | 7mer-m8 | 1236838 | 1236858 | 148 | -14.1 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000159692.15 | ENST00000510568.1 | CTBP1-209 | hsa-miR-5688 | chr4 | 1237049 | 1237055 | 7mer-m8 | 1237048 | 1237069 | 140 | -11.59 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000159692.15 | ENST00000510568.1 | CTBP1-209 | hsa-miR-5688 | chr4 | 1237247 | 1237253 | 7mer-m8 | 1237246 | 1237267 | 140 | -12.04 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000159692.15 | ENST00000510568.1 | CTBP1-209 | hsa-miR-5688 | chr4 | 1237317 | 1237323 | 7mer-m8 | 1237316 | 1237337 | 140 | -12.04 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000159692.15 | ENST00000510568.1 | CTBP1-209 | hsa-miR-5688 | chr4 | 1237422 | 1237428 | 7mer-m8 | 1237421 | 1237443 | 154 | -19.11 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000159692.15 | ENST00000510568.1 | CTBP1-209 | hsa-miR-5688 | chr4 | 1237527 | 1237533 | 7mer-m8 | 1237526 | 1237548 | 154 | -19.11 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000159692.15 | ENST00000510568.1 | CTBP1-209 | hsa-miR-5688 | chr4 | 1237562 | 1237568 | 7mer-m8 | 1237561 | 1237581 | 156 | -19.43 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000159692.15 | ENST00000510568.1 | CTBP1-209 | hsa-miR-5688 | chr4 | 1237632 | 1237638 | 7mer-m8 | 1237631 | 1237653 | 154 | -19.11 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000159692.15 | ENST00000510568.1 | CTBP1-209 | hsa-miR-5688 | chr4 | 1237667 | 1237673 | 7mer-m8 | 1237666 | 1237688 | 154 | -19.11 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000159692.15 | ENST00000510568.1 | CTBP1-209 | hsa-miR-5688 | chr4 | 1237702 | 1237708 | 7mer-m8 | 1237701 | 1237723 | 154 | -19.11 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000159692.15 | ENST00000510568.1 | CTBP1-209 | hsa-miR-5688 | chr4 | 1237772 | 1237778 | 7mer-m8 | 1237771 | 1237793 | 154 | -19.11 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000159692.15 | ENST00000290921.10 | CTBP1-201 | hsa-miR-4775 | chr4 | 1211508 | 1211514 | 7mer-m8 | 1211507 | 1211528 | 140 | -5.98 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000159692.15 | ENST00000382952.7 | CTBP1-203 | hsa-miR-4775 | chr4 | 1211508 | 1211514 | 7mer-m8 | 1211507 | 1211528 | 140 | -5.98 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000159692.15 | ENST00000510568.1 | CTBP1-209 | hsa-miR-589-3p | chr4 | 1236094 | 1236100 | 7mer-m8 | 1236093 | 1236113 | 153 | -27.67 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for CTBP1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for CTBP1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1104722 | chr4_1220039_- | 2.98929022424257e-05 | 0.333793411585673 | 0.0497377793515408 | 0.160516308954632 | 0.184836742629458 | 0.10885677992002 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.79067783274371e-31 | 0.598213504867674 | 2.63368948824904e-33 | 0.612470705887517 | 3.83327603606519e-26 | 0.552213086977042 |
| AC | 9.36742109188568e-99 | 0.913345764701218 | 1.97787523965317e-86 | 0.889722717541668 | 4.34074044701188e-11 | 0.401270051857216 |
| PCC | 2.29092186145162e-65 | 0.88709046072856 | 4.38506783963886e-82 | 0.926367352979831 | 0.0213934122970891 | 0.16642191277033 |
| CER | 2.97698574410987e-21 | 0.674577184978711 | 2.42853067795266e-37 | 0.817822943153005 | 0.0676023376630961 | 0.149637314069593 |
| TCX | 9.03826921126647e-29 | 0.753714867927621 | 6.33213379227053e-38 | 0.821447948383032 | 0.685190341966267 | -0.0333699458909991 |
| FP | 2.8535315489092e-16 | 0.562973696037627 | 2.67417712335618e-17 | 0.578679447663345 | 0.000230162864589068 | 0.272749371052177 |
| IFG | 6.56895172175839e-07 | 0.816163144807358 | 2.2734828698734e-06 | 0.793021748683206 | 0.326870318624888 | 0.204473637615529 |
| PG | 2.18037032275043e-08 | 0.396150606366967 | 3.98027841331648e-08 | 0.389298121670902 | 0.0800415786118589 | 0.128682166367925 |
| STG | 1.69138138539012e-24 | 0.84961495500166 | 8.49857649225668e-12 | 0.660080943196144 | 0.1607918163563 | 0.154410115033046 |
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Relation with AD stages for CTBP1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for CTBP1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CTBP1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| CTBP1 | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
| CTBP1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| CTBP1 | C1527249 | Colorectal Cancer | 1 | CTD_human |
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