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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for SPACA6 |
 Gene summary |
| Gene information | Gene symbol | SPACA6 | Gene ID | 147650 |
| Gene name | sperm acrosome associated 6 | |
| Synonyms | LET7EH|LINC00085|NCRNA00085|SPACA6P | |
| Cytomap | 19q13.41 | |
| Type of gene | protein-coding | |
| Description | sperm acrosome membrane-associated protein 6BACHELOR-like proteinLet-7e hostlong intergenic non-protein coding RNA 85sperm acrosome associated 6, pseudogene | |
| Modification date | 20200313 | |
| UniProtAcc | W5XKT8, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for SPACA6 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_776195(51696471, +), ADediting_776196(51696479, +), ADediting_776197(51696525, +), ADediting_776198(51696533, +), ADediting_776199(51696534, +), ADediting_776200(51696547, +), ADediting_776201(51696548, +), ADediting_776202(51696552, +), ADediting_776203(51696565, +), ADediting_776204(51696573, +), ADediting_776205(51696574, +), ADediting_776206(51696577, +), ADediting_776207(51696587, +), ADediting_776208(51696589, +), ADediting_776209(51696671, +), ADediting_776210(51696683, +), ADediting_776211(51696684, +), ADediting_776212(51696688, +), ADediting_776213(51696696, +), ADediting_776214(51696701, +), ADediting_776215(51696710, +), ADediting_776216(51696711, +), ADediting_776217(51696723, +), ADediting_776218(51696729, +), ADediting_776219(51696741, +), ADediting_776220(51696989, +), ADediting_776221(51696990, +), ADediting_776222(51697077, +), ADediting_776223(51699024, +), ADediting_776224(51699026, +), ADediting_776225(51699030, +), ADediting_776226(51699043, +), ADediting_776227(51699074, +), ADediting_776228(51699080, +), ADediting_776229(51699088, +), ADediting_776230(51699122, +), ADediting_776231(51699139, +), ADediting_776232(51699143, +), ADediting_776233(51699144, +), ADediting_776234(51699149, +), ADediting_776235(51699152, +), ADediting_776236(51699192, +), ADediting_776237(51699218, +), ADediting_776238(51699244, +), ADediting_776239(51699261, +), ADediting_776240(51699990, +), ADediting_776241(51699992, +), ADediting_776242(51699999, +), ADediting_776243(51700025, +), ADediting_776244(51700034, +), ADediting_776245(51700058, +), ADediting_776246(51700133, +), ADediting_776247(51700134, +), ADediting_776248(51700139, +), ADediting_776249(51700143, +), ADediting_776250(51700160, +), ADediting_776251(51700169, +), ADediting_776252(51700175, +), ADediting_776253(51700195, +), ADediting_776254(51700203, +), ADediting_776255(51700204, +), ADediting_776256(51700233, +), ADediting_776257(51700234, +), ADediting_776258(51700249, +), ADediting_776259(51700966, +), ADediting_776260(51700967, +), ADediting_776261(51701002, +), ADediting_776262(51701072, +), ADediting_776263(51701101, +), ADediting_776264(51701123, +), ADediting_776265(51701128, +), ADediting_776266(51701137, +), ADediting_776267(51701143, +), ADediting_776268(51701938, +), ADediting_776269(51701952, +), ADediting_776270(51701965, +), ADediting_776271(51706893, +), ADediting_776272(51707325, +), ADediting_776273(51707338, +), ADediting_776274(51707384, +), ADediting_776275(51707474, +), ADediting_776276(51709102, +), ADediting_776279(51712086, +), ADediting_1557802(51696522, +), ADediting_1557803(51696670, +), ADediting_1557804(51699127, +), ADediting_1557805(51699155, +), ADediting_1557806(51699256, +), ADediting_1557807(51700039, +), ADediting_1557808(51700044, +), ADediting_1557809(51700150, +), ADediting_1557810(51700156, +), ADediting_1557811(51700189, +), ADediting_1557812(51700236, +), ADediting_1557813(51700989, +), ADediting_1557814(51701007, +), ADediting_1557815(51701095, +), ADediting_1557816(51701142, +), ADediting_1557817(51701818, +), ADediting_1557818(51701834, +), ADediting_1557819(51701939, +), ADediting_1557820(51703708, +), ADediting_1557821(51703717, +), |
Top |
RNA editing positional annotations for SPACA6 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_776195 | chr19_51696471_+ | intronic |
| ADediting_776196 | chr19_51696479_+ | intronic |
| ADediting_776197 | chr19_51696525_+ | intronic |
| ADediting_776198 | chr19_51696533_+ | intronic |
| ADediting_776199 | chr19_51696534_+ | intronic |
| ADediting_776200 | chr19_51696547_+ | intronic |
| ADediting_776201 | chr19_51696548_+ | intronic |
| ADediting_776202 | chr19_51696552_+ | intronic |
| ADediting_776203 | chr19_51696565_+ | intronic |
| ADediting_776204 | chr19_51696573_+ | intronic |
| ADediting_776205 | chr19_51696574_+ | intronic |
| ADediting_776206 | chr19_51696577_+ | intronic |
| ADediting_776207 | chr19_51696587_+ | intronic |
| ADediting_776208 | chr19_51696589_+ | intronic |
| ADediting_776209 | chr19_51696671_+ | intronic |
| ADediting_776210 | chr19_51696683_+ | intronic |
| ADediting_776211 | chr19_51696684_+ | intronic |
| ADediting_776212 | chr19_51696688_+ | intronic |
| ADediting_776213 | chr19_51696696_+ | intronic |
| ADediting_776214 | chr19_51696701_+ | intronic |
| ADediting_776215 | chr19_51696710_+ | intronic |
| ADediting_776216 | chr19_51696711_+ | intronic |
| ADediting_776217 | chr19_51696723_+ | intronic |
| ADediting_776218 | chr19_51696729_+ | intronic |
| ADediting_776219 | chr19_51696741_+ | intronic |
| ADediting_776220 | chr19_51696989_+ | intronic |
| ADediting_776221 | chr19_51696990_+ | intronic |
| ADediting_776222 | chr19_51697077_+ | intronic |
| ADediting_776223 | chr19_51699024_+ | intronic |
| ADediting_776224 | chr19_51699026_+ | intronic |
| ADediting_776225 | chr19_51699030_+ | intronic |
| ADediting_776226 | chr19_51699043_+ | intronic |
| ADediting_776227 | chr19_51699074_+ | intronic |
| ADediting_776228 | chr19_51699080_+ | intronic |
| ADediting_776229 | chr19_51699088_+ | intronic |
| ADediting_776230 | chr19_51699122_+ | intronic |
| ADediting_776231 | chr19_51699139_+ | intronic |
| ADediting_776232 | chr19_51699143_+ | intronic |
| ADediting_776233 | chr19_51699144_+ | intronic |
| ADediting_776234 | chr19_51699149_+ | intronic |
| ADediting_776235 | chr19_51699152_+ | intronic |
| ADediting_776236 | chr19_51699192_+ | intronic |
| ADediting_776237 | chr19_51699218_+ | intronic |
| ADediting_776238 | chr19_51699244_+ | intronic |
| ADediting_776239 | chr19_51699261_+ | intronic |
| ADediting_776240 | chr19_51699990_+ | intronic |
| ADediting_776241 | chr19_51699992_+ | intronic |
| ADediting_776242 | chr19_51699999_+ | intronic |
| ADediting_776243 | chr19_51700025_+ | intronic |
| ADediting_776244 | chr19_51700034_+ | intronic |
| ADediting_776245 | chr19_51700058_+ | intronic |
| ADediting_776246 | chr19_51700133_+ | intronic |
| ADediting_776247 | chr19_51700134_+ | intronic |
| ADediting_776248 | chr19_51700139_+ | intronic |
| ADediting_776249 | chr19_51700143_+ | intronic |
| ADediting_776250 | chr19_51700160_+ | intronic |
| ADediting_776251 | chr19_51700169_+ | intronic |
| ADediting_776252 | chr19_51700175_+ | intronic |
| ADediting_776253 | chr19_51700195_+ | intronic |
| ADediting_776254 | chr19_51700203_+ | intronic |
| ADediting_776255 | chr19_51700204_+ | intronic |
| ADediting_776256 | chr19_51700233_+ | intronic |
| ADediting_776257 | chr19_51700234_+ | intronic |
| ADediting_776258 | chr19_51700249_+ | intronic |
| ADediting_776259 | chr19_51700966_+ | intronic |
| ADediting_776260 | chr19_51700967_+ | intronic |
| ADediting_776261 | chr19_51701002_+ | intronic |
| ADediting_776262 | chr19_51701072_+ | intronic |
| ADediting_776263 | chr19_51701101_+ | intronic |
| ADediting_776264 | chr19_51701123_+ | intronic |
| ADediting_776265 | chr19_51701128_+ | intronic |
| ADediting_776266 | chr19_51701137_+ | intronic |
| ADediting_776267 | chr19_51701143_+ | intronic |
| ADediting_776268 | chr19_51701938_+ | intronic |
| ADediting_776269 | chr19_51701952_+ | intronic |
| ADediting_776270 | chr19_51701965_+ | intronic |
| ADediting_776271 | chr19_51706893_+ | intergenic |
| ADediting_776272 | chr19_51707325_+ | intergenic |
| ADediting_776273 | chr19_51707338_+ | intergenic |
| ADediting_776274 | chr19_51707384_+ | intergenic |
| ADediting_776275 | chr19_51707474_+ | intergenic |
| ADediting_776276 | chr19_51709102_+ | intergenic |
| ADediting_776279 | chr19_51712086_+ | intergenic |
| ADediting_1557802 | chr19_51696522_+ | intronic |
| ADediting_1557803 | chr19_51696670_+ | intronic |
| ADediting_1557804 | chr19_51699127_+ | intronic |
| ADediting_1557805 | chr19_51699155_+ | intronic |
| ADediting_1557806 | chr19_51699256_+ | intronic |
| ADediting_1557807 | chr19_51700039_+ | intronic |
| ADediting_1557808 | chr19_51700044_+ | intronic |
| ADediting_1557809 | chr19_51700150_+ | intronic |
| ADediting_1557810 | chr19_51700156_+ | intronic |
| ADediting_1557811 | chr19_51700189_+ | intronic |
| ADediting_1557812 | chr19_51700236_+ | intronic |
| ADediting_1557813 | chr19_51700989_+ | intronic |
| ADediting_1557814 | chr19_51701007_+ | intronic |
| ADediting_1557815 | chr19_51701095_+ | intronic |
| ADediting_1557816 | chr19_51701142_+ | intronic |
| ADediting_1557817 | chr19_51701818_+ | intronic |
| ADediting_1557818 | chr19_51701834_+ | intronic |
| ADediting_1557819 | chr19_51701939_+ | intronic |
| ADediting_1557820 | chr19_51703708_+ | intronic |
| ADediting_1557821 | chr19_51703717_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_776195 | chr19_51696471_+ | SINE | Alu | Name=AluJo |
| ADediting_776196 | chr19_51696479_+ | SINE | Alu | Name=AluJo |
| ADediting_776197 | chr19_51696525_+ | SINE | Alu | Name=AluJo |
| ADediting_776198 | chr19_51696533_+ | SINE | Alu | Name=AluJo |
| ADediting_776199 | chr19_51696534_+ | SINE | Alu | Name=AluJo |
| ADediting_776200 | chr19_51696547_+ | SINE | Alu | Name=AluJo |
| ADediting_776201 | chr19_51696548_+ | SINE | Alu | Name=AluJo |
| ADediting_776202 | chr19_51696552_+ | SINE | Alu | Name=AluJo |
| ADediting_776203 | chr19_51696565_+ | SINE | Alu | Name=AluJo |
| ADediting_776204 | chr19_51696573_+ | SINE | Alu | Name=AluJo |
| ADediting_776205 | chr19_51696574_+ | SINE | Alu | Name=AluJo |
| ADediting_776206 | chr19_51696577_+ | SINE | Alu | Name=AluJo |
| ADediting_776207 | chr19_51696587_+ | SINE | Alu | Name=AluJo |
| ADediting_776208 | chr19_51696589_+ | SINE | Alu | Name=AluJo |
| ADediting_776209 | chr19_51696671_+ | SINE | Alu | Name=AluJo |
| ADediting_776210 | chr19_51696683_+ | SINE | Alu | Name=AluJo |
| ADediting_776211 | chr19_51696684_+ | SINE | Alu | Name=AluJo |
| ADediting_776212 | chr19_51696688_+ | SINE | Alu | Name=AluJo |
| ADediting_776213 | chr19_51696696_+ | SINE | Alu | Name=AluJo |
| ADediting_776214 | chr19_51696701_+ | SINE | Alu | Name=AluJo |
| ADediting_776215 | chr19_51696710_+ | SINE | Alu | Name=AluJo |
| ADediting_776216 | chr19_51696711_+ | SINE | Alu | Name=AluJo |
| ADediting_776217 | chr19_51696723_+ | SINE | Alu | Name=AluJo |
| ADediting_776218 | chr19_51696729_+ | SINE | Alu | Name=AluJo |
| ADediting_776219 | chr19_51696741_+ | SINE | Alu | Name=AluJo |
| ADediting_776220 | chr19_51696989_+ | DNA | hAT-Charlie | Name=MER5A |
| ADediting_776221 | chr19_51696990_+ | DNA | hAT-Charlie | Name=MER5A |
| ADediting_776222 | chr19_51697077_+ | DNA | hAT-Charlie | Name=MER5A |
| ADediting_776223 | chr19_51699024_+ | SINE | Alu | Name=AluJr |
| ADediting_776224 | chr19_51699026_+ | SINE | Alu | Name=AluJr |
| ADediting_776225 | chr19_51699030_+ | SINE | Alu | Name=AluJr |
| ADediting_776226 | chr19_51699043_+ | SINE | Alu | Name=AluJr |
| ADediting_776227 | chr19_51699074_+ | SINE | Alu | Name=AluJr |
| ADediting_776228 | chr19_51699080_+ | SINE | Alu | Name=AluJr |
| ADediting_776229 | chr19_51699088_+ | SINE | Alu | Name=AluJr |
| ADediting_776230 | chr19_51699122_+ | SINE | Alu | Name=AluJr |
| ADediting_776231 | chr19_51699139_+ | SINE | Alu | Name=AluJr |
| ADediting_776232 | chr19_51699143_+ | SINE | Alu | Name=AluJr |
| ADediting_776233 | chr19_51699144_+ | SINE | Alu | Name=AluJr |
| ADediting_776234 | chr19_51699149_+ | SINE | Alu | Name=AluJr |
| ADediting_776235 | chr19_51699152_+ | SINE | Alu | Name=AluJr |
| ADediting_776236 | chr19_51699192_+ | SINE | Alu | Name=AluJr |
| ADediting_776237 | chr19_51699218_+ | SINE | Alu | Name=AluJr |
| ADediting_776238 | chr19_51699244_+ | SINE | Alu | Name=AluJr |
| ADediting_776239 | chr19_51699261_+ | SINE | Alu | Name=AluJr |
| ADediting_776240 | chr19_51699990_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776241 | chr19_51699992_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776242 | chr19_51699999_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776243 | chr19_51700025_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776244 | chr19_51700034_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776245 | chr19_51700058_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776246 | chr19_51700133_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776247 | chr19_51700134_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776248 | chr19_51700139_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776249 | chr19_51700143_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776250 | chr19_51700160_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776251 | chr19_51700169_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776252 | chr19_51700175_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776253 | chr19_51700195_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776254 | chr19_51700203_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776255 | chr19_51700204_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776256 | chr19_51700233_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776257 | chr19_51700234_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776258 | chr19_51700249_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776259 | chr19_51700966_+ | SINE | Alu | Name=AluSz |
| ADediting_776260 | chr19_51700967_+ | SINE | Alu | Name=AluSz |
| ADediting_776261 | chr19_51701002_+ | SINE | Alu | Name=AluSz |
| ADediting_776262 | chr19_51701072_+ | SINE | Alu | Name=AluSz |
| ADediting_776263 | chr19_51701101_+ | SINE | Alu | Name=AluSz |
| ADediting_776264 | chr19_51701123_+ | SINE | Alu | Name=AluSz |
| ADediting_776265 | chr19_51701128_+ | SINE | Alu | Name=AluSz |
| ADediting_776266 | chr19_51701137_+ | SINE | Alu | Name=AluSz |
| ADediting_776267 | chr19_51701143_+ | SINE | Alu | Name=AluSz |
| ADediting_776268 | chr19_51701938_+ | SINE | Alu | Name=AluSz |
| ADediting_776269 | chr19_51701952_+ | SINE | Alu | Name=AluSz |
| ADediting_776270 | chr19_51701965_+ | SINE | Alu | Name=AluSz |
| ADediting_776271 | chr19_51706893_+ | SINE | Alu | Name=AluSq2 |
| ADediting_776272 | chr19_51707325_+ | SINE | Alu | Name=AluSz |
| ADediting_776273 | chr19_51707338_+ | SINE | Alu | Name=AluSz |
| ADediting_776274 | chr19_51707384_+ | SINE | Alu | Name=AluSz |
| ADediting_776275 | chr19_51707474_+ | SINE | Alu | Name=AluSz |
| ADediting_776276 | chr19_51709102_+ | SINE | Alu | Name=AluJb |
| ADediting_776279 | chr19_51712086_+ | SINE | Alu | Name=AluSz |
| ADediting_1557802 | chr19_51696522_+ | SINE | Alu | Name=AluJo |
| ADediting_1557803 | chr19_51696670_+ | SINE | Alu | Name=AluJo |
| ADediting_1557804 | chr19_51699127_+ | SINE | Alu | Name=AluJr |
| ADediting_1557805 | chr19_51699155_+ | SINE | Alu | Name=AluJr |
| ADediting_1557806 | chr19_51699256_+ | SINE | Alu | Name=AluJr |
| ADediting_1557807 | chr19_51700039_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1557808 | chr19_51700044_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1557809 | chr19_51700150_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1557810 | chr19_51700156_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1557811 | chr19_51700189_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1557812 | chr19_51700236_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1557813 | chr19_51700989_+ | SINE | Alu | Name=AluSz |
| ADediting_1557814 | chr19_51701007_+ | SINE | Alu | Name=AluSz |
| ADediting_1557815 | chr19_51701095_+ | SINE | Alu | Name=AluSz |
| ADediting_1557816 | chr19_51701142_+ | SINE | Alu | Name=AluSz |
| ADediting_1557817 | chr19_51701818_+ | SINE | Alu | Name=AluSz |
| ADediting_1557818 | chr19_51701834_+ | SINE | Alu | Name=AluSz |
| ADediting_1557819 | chr19_51701939_+ | SINE | Alu | Name=AluSz |
| ADediting_1557820 | chr19_51703708_+ | SINE | Alu | Name=AluJr |
| ADediting_1557821 | chr19_51703717_+ | SINE | Alu | Name=AluJr |
Top |
RNA A-to-I editing events in the alternative splicing sites for SPACA6 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| ES | ADediting_776269 | chr19_51701952_+ | 51701947:51701969 | 3ss | 15i | TTGTAATCTCATCTACTCAGGAG | 5.71 | TTGTAGTCTCATCTACTCAGGAG | 4.54 |
| ES | ADediting_776269 | chr19_51701952_+ | 51701947:51701969 | 3ss | 15i | TTGTAATCTCATCTACTCAGGAG | 5.71 | TTGTAGTCTCATCTACTCAGGAG | 4.54 |
| ES | ADediting_776270 | chr19_51701965_+ | 51701947:51701969 | 3ss | 2i | TTGTAATCTCATCTACTCAGGAG | 5.71 | TTGTAATCTCATCTACTCGGGAG | -2.25 |
| ES | ADediting_776270 | chr19_51701965_+ | 51701947:51701969 | 3ss | 2i | TTGTAATCTCATCTACTCAGGAG | 5.71 | TTGTAATCTCATCTACTCGGGAG | -2.25 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for SPACA6 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |