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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for SPACA6 |
 Gene summary |
| Gene information | Gene symbol | SPACA6 | Gene ID | 147650 |
| Gene name | sperm acrosome associated 6 | |
| Synonyms | LET7EH|LINC00085|NCRNA00085|SPACA6P | |
| Cytomap | 19q13.41 | |
| Type of gene | protein-coding | |
| Description | sperm acrosome membrane-associated protein 6BACHELOR-like proteinLet-7e hostlong intergenic non-protein coding RNA 85sperm acrosome associated 6, pseudogene | |
| Modification date | 20200313 | |
| UniProtAcc | W5XKT8, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for SPACA6 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_776195(51696471, +), ADediting_776196(51696479, +), ADediting_776197(51696525, +), ADediting_776198(51696533, +), ADediting_776199(51696534, +), ADediting_776200(51696547, +), ADediting_776201(51696548, +), ADediting_776202(51696552, +), ADediting_776203(51696565, +), ADediting_776204(51696573, +), ADediting_776205(51696574, +), ADediting_776206(51696577, +), ADediting_776207(51696587, +), ADediting_776208(51696589, +), ADediting_776209(51696671, +), ADediting_776210(51696683, +), ADediting_776211(51696684, +), ADediting_776212(51696688, +), ADediting_776213(51696696, +), ADediting_776214(51696701, +), ADediting_776215(51696710, +), ADediting_776216(51696711, +), ADediting_776217(51696723, +), ADediting_776218(51696729, +), ADediting_776219(51696741, +), ADediting_776220(51696989, +), ADediting_776221(51696990, +), ADediting_776222(51697077, +), ADediting_776223(51699024, +), ADediting_776224(51699026, +), ADediting_776225(51699030, +), ADediting_776226(51699043, +), ADediting_776227(51699074, +), ADediting_776228(51699080, +), ADediting_776229(51699088, +), ADediting_776230(51699122, +), ADediting_776231(51699139, +), ADediting_776232(51699143, +), ADediting_776233(51699144, +), ADediting_776234(51699149, +), ADediting_776235(51699152, +), ADediting_776236(51699192, +), ADediting_776237(51699218, +), ADediting_776238(51699244, +), ADediting_776239(51699261, +), ADediting_776240(51699990, +), ADediting_776241(51699992, +), ADediting_776242(51699999, +), ADediting_776243(51700025, +), ADediting_776244(51700034, +), ADediting_776245(51700058, +), ADediting_776246(51700133, +), ADediting_776247(51700134, +), ADediting_776248(51700139, +), ADediting_776249(51700143, +), ADediting_776250(51700160, +), ADediting_776251(51700169, +), ADediting_776252(51700175, +), ADediting_776253(51700195, +), ADediting_776254(51700203, +), ADediting_776255(51700204, +), ADediting_776256(51700233, +), ADediting_776257(51700234, +), ADediting_776258(51700249, +), ADediting_776259(51700966, +), ADediting_776260(51700967, +), ADediting_776261(51701002, +), ADediting_776262(51701072, +), ADediting_776263(51701101, +), ADediting_776264(51701123, +), ADediting_776265(51701128, +), ADediting_776266(51701137, +), ADediting_776267(51701143, +), ADediting_776268(51701938, +), ADediting_776269(51701952, +), ADediting_776270(51701965, +), ADediting_776271(51706893, +), ADediting_776272(51707325, +), ADediting_776273(51707338, +), ADediting_776274(51707384, +), ADediting_776275(51707474, +), ADediting_776276(51709102, +), ADediting_776279(51712086, +), ADediting_1557802(51696522, +), ADediting_1557803(51696670, +), ADediting_1557804(51699127, +), ADediting_1557805(51699155, +), ADediting_1557806(51699256, +), ADediting_1557807(51700039, +), ADediting_1557808(51700044, +), ADediting_1557809(51700150, +), ADediting_1557810(51700156, +), ADediting_1557811(51700189, +), ADediting_1557812(51700236, +), ADediting_1557813(51700989, +), ADediting_1557814(51701007, +), ADediting_1557815(51701095, +), ADediting_1557816(51701142, +), ADediting_1557817(51701818, +), ADediting_1557818(51701834, +), ADediting_1557819(51701939, +), ADediting_1557820(51703708, +), ADediting_1557821(51703717, +), |
Top |
RNA editing positional annotations for SPACA6 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_776195 | chr19_51696471_+ | intronic |
| ADediting_776196 | chr19_51696479_+ | intronic |
| ADediting_776197 | chr19_51696525_+ | intronic |
| ADediting_776198 | chr19_51696533_+ | intronic |
| ADediting_776199 | chr19_51696534_+ | intronic |
| ADediting_776200 | chr19_51696547_+ | intronic |
| ADediting_776201 | chr19_51696548_+ | intronic |
| ADediting_776202 | chr19_51696552_+ | intronic |
| ADediting_776203 | chr19_51696565_+ | intronic |
| ADediting_776204 | chr19_51696573_+ | intronic |
| ADediting_776205 | chr19_51696574_+ | intronic |
| ADediting_776206 | chr19_51696577_+ | intronic |
| ADediting_776207 | chr19_51696587_+ | intronic |
| ADediting_776208 | chr19_51696589_+ | intronic |
| ADediting_776209 | chr19_51696671_+ | intronic |
| ADediting_776210 | chr19_51696683_+ | intronic |
| ADediting_776211 | chr19_51696684_+ | intronic |
| ADediting_776212 | chr19_51696688_+ | intronic |
| ADediting_776213 | chr19_51696696_+ | intronic |
| ADediting_776214 | chr19_51696701_+ | intronic |
| ADediting_776215 | chr19_51696710_+ | intronic |
| ADediting_776216 | chr19_51696711_+ | intronic |
| ADediting_776217 | chr19_51696723_+ | intronic |
| ADediting_776218 | chr19_51696729_+ | intronic |
| ADediting_776219 | chr19_51696741_+ | intronic |
| ADediting_776220 | chr19_51696989_+ | intronic |
| ADediting_776221 | chr19_51696990_+ | intronic |
| ADediting_776222 | chr19_51697077_+ | intronic |
| ADediting_776223 | chr19_51699024_+ | intronic |
| ADediting_776224 | chr19_51699026_+ | intronic |
| ADediting_776225 | chr19_51699030_+ | intronic |
| ADediting_776226 | chr19_51699043_+ | intronic |
| ADediting_776227 | chr19_51699074_+ | intronic |
| ADediting_776228 | chr19_51699080_+ | intronic |
| ADediting_776229 | chr19_51699088_+ | intronic |
| ADediting_776230 | chr19_51699122_+ | intronic |
| ADediting_776231 | chr19_51699139_+ | intronic |
| ADediting_776232 | chr19_51699143_+ | intronic |
| ADediting_776233 | chr19_51699144_+ | intronic |
| ADediting_776234 | chr19_51699149_+ | intronic |
| ADediting_776235 | chr19_51699152_+ | intronic |
| ADediting_776236 | chr19_51699192_+ | intronic |
| ADediting_776237 | chr19_51699218_+ | intronic |
| ADediting_776238 | chr19_51699244_+ | intronic |
| ADediting_776239 | chr19_51699261_+ | intronic |
| ADediting_776240 | chr19_51699990_+ | intronic |
| ADediting_776241 | chr19_51699992_+ | intronic |
| ADediting_776242 | chr19_51699999_+ | intronic |
| ADediting_776243 | chr19_51700025_+ | intronic |
| ADediting_776244 | chr19_51700034_+ | intronic |
| ADediting_776245 | chr19_51700058_+ | intronic |
| ADediting_776246 | chr19_51700133_+ | intronic |
| ADediting_776247 | chr19_51700134_+ | intronic |
| ADediting_776248 | chr19_51700139_+ | intronic |
| ADediting_776249 | chr19_51700143_+ | intronic |
| ADediting_776250 | chr19_51700160_+ | intronic |
| ADediting_776251 | chr19_51700169_+ | intronic |
| ADediting_776252 | chr19_51700175_+ | intronic |
| ADediting_776253 | chr19_51700195_+ | intronic |
| ADediting_776254 | chr19_51700203_+ | intronic |
| ADediting_776255 | chr19_51700204_+ | intronic |
| ADediting_776256 | chr19_51700233_+ | intronic |
| ADediting_776257 | chr19_51700234_+ | intronic |
| ADediting_776258 | chr19_51700249_+ | intronic |
| ADediting_776259 | chr19_51700966_+ | intronic |
| ADediting_776260 | chr19_51700967_+ | intronic |
| ADediting_776261 | chr19_51701002_+ | intronic |
| ADediting_776262 | chr19_51701072_+ | intronic |
| ADediting_776263 | chr19_51701101_+ | intronic |
| ADediting_776264 | chr19_51701123_+ | intronic |
| ADediting_776265 | chr19_51701128_+ | intronic |
| ADediting_776266 | chr19_51701137_+ | intronic |
| ADediting_776267 | chr19_51701143_+ | intronic |
| ADediting_776268 | chr19_51701938_+ | intronic |
| ADediting_776269 | chr19_51701952_+ | intronic |
| ADediting_776270 | chr19_51701965_+ | intronic |
| ADediting_776271 | chr19_51706893_+ | intergenic |
| ADediting_776272 | chr19_51707325_+ | intergenic |
| ADediting_776273 | chr19_51707338_+ | intergenic |
| ADediting_776274 | chr19_51707384_+ | intergenic |
| ADediting_776275 | chr19_51707474_+ | intergenic |
| ADediting_776276 | chr19_51709102_+ | intergenic |
| ADediting_776279 | chr19_51712086_+ | intergenic |
| ADediting_1557802 | chr19_51696522_+ | intronic |
| ADediting_1557803 | chr19_51696670_+ | intronic |
| ADediting_1557804 | chr19_51699127_+ | intronic |
| ADediting_1557805 | chr19_51699155_+ | intronic |
| ADediting_1557806 | chr19_51699256_+ | intronic |
| ADediting_1557807 | chr19_51700039_+ | intronic |
| ADediting_1557808 | chr19_51700044_+ | intronic |
| ADediting_1557809 | chr19_51700150_+ | intronic |
| ADediting_1557810 | chr19_51700156_+ | intronic |
| ADediting_1557811 | chr19_51700189_+ | intronic |
| ADediting_1557812 | chr19_51700236_+ | intronic |
| ADediting_1557813 | chr19_51700989_+ | intronic |
| ADediting_1557814 | chr19_51701007_+ | intronic |
| ADediting_1557815 | chr19_51701095_+ | intronic |
| ADediting_1557816 | chr19_51701142_+ | intronic |
| ADediting_1557817 | chr19_51701818_+ | intronic |
| ADediting_1557818 | chr19_51701834_+ | intronic |
| ADediting_1557819 | chr19_51701939_+ | intronic |
| ADediting_1557820 | chr19_51703708_+ | intronic |
| ADediting_1557821 | chr19_51703717_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_776195 | chr19_51696471_+ | SINE | Alu | Name=AluJo |
| ADediting_776196 | chr19_51696479_+ | SINE | Alu | Name=AluJo |
| ADediting_776197 | chr19_51696525_+ | SINE | Alu | Name=AluJo |
| ADediting_776198 | chr19_51696533_+ | SINE | Alu | Name=AluJo |
| ADediting_776199 | chr19_51696534_+ | SINE | Alu | Name=AluJo |
| ADediting_776200 | chr19_51696547_+ | SINE | Alu | Name=AluJo |
| ADediting_776201 | chr19_51696548_+ | SINE | Alu | Name=AluJo |
| ADediting_776202 | chr19_51696552_+ | SINE | Alu | Name=AluJo |
| ADediting_776203 | chr19_51696565_+ | SINE | Alu | Name=AluJo |
| ADediting_776204 | chr19_51696573_+ | SINE | Alu | Name=AluJo |
| ADediting_776205 | chr19_51696574_+ | SINE | Alu | Name=AluJo |
| ADediting_776206 | chr19_51696577_+ | SINE | Alu | Name=AluJo |
| ADediting_776207 | chr19_51696587_+ | SINE | Alu | Name=AluJo |
| ADediting_776208 | chr19_51696589_+ | SINE | Alu | Name=AluJo |
| ADediting_776209 | chr19_51696671_+ | SINE | Alu | Name=AluJo |
| ADediting_776210 | chr19_51696683_+ | SINE | Alu | Name=AluJo |
| ADediting_776211 | chr19_51696684_+ | SINE | Alu | Name=AluJo |
| ADediting_776212 | chr19_51696688_+ | SINE | Alu | Name=AluJo |
| ADediting_776213 | chr19_51696696_+ | SINE | Alu | Name=AluJo |
| ADediting_776214 | chr19_51696701_+ | SINE | Alu | Name=AluJo |
| ADediting_776215 | chr19_51696710_+ | SINE | Alu | Name=AluJo |
| ADediting_776216 | chr19_51696711_+ | SINE | Alu | Name=AluJo |
| ADediting_776217 | chr19_51696723_+ | SINE | Alu | Name=AluJo |
| ADediting_776218 | chr19_51696729_+ | SINE | Alu | Name=AluJo |
| ADediting_776219 | chr19_51696741_+ | SINE | Alu | Name=AluJo |
| ADediting_776220 | chr19_51696989_+ | DNA | hAT-Charlie | Name=MER5A |
| ADediting_776221 | chr19_51696990_+ | DNA | hAT-Charlie | Name=MER5A |
| ADediting_776222 | chr19_51697077_+ | DNA | hAT-Charlie | Name=MER5A |
| ADediting_776223 | chr19_51699024_+ | SINE | Alu | Name=AluJr |
| ADediting_776224 | chr19_51699026_+ | SINE | Alu | Name=AluJr |
| ADediting_776225 | chr19_51699030_+ | SINE | Alu | Name=AluJr |
| ADediting_776226 | chr19_51699043_+ | SINE | Alu | Name=AluJr |
| ADediting_776227 | chr19_51699074_+ | SINE | Alu | Name=AluJr |
| ADediting_776228 | chr19_51699080_+ | SINE | Alu | Name=AluJr |
| ADediting_776229 | chr19_51699088_+ | SINE | Alu | Name=AluJr |
| ADediting_776230 | chr19_51699122_+ | SINE | Alu | Name=AluJr |
| ADediting_776231 | chr19_51699139_+ | SINE | Alu | Name=AluJr |
| ADediting_776232 | chr19_51699143_+ | SINE | Alu | Name=AluJr |
| ADediting_776233 | chr19_51699144_+ | SINE | Alu | Name=AluJr |
| ADediting_776234 | chr19_51699149_+ | SINE | Alu | Name=AluJr |
| ADediting_776235 | chr19_51699152_+ | SINE | Alu | Name=AluJr |
| ADediting_776236 | chr19_51699192_+ | SINE | Alu | Name=AluJr |
| ADediting_776237 | chr19_51699218_+ | SINE | Alu | Name=AluJr |
| ADediting_776238 | chr19_51699244_+ | SINE | Alu | Name=AluJr |
| ADediting_776239 | chr19_51699261_+ | SINE | Alu | Name=AluJr |
| ADediting_776240 | chr19_51699990_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776241 | chr19_51699992_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776242 | chr19_51699999_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776243 | chr19_51700025_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776244 | chr19_51700034_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776245 | chr19_51700058_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776246 | chr19_51700133_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776247 | chr19_51700134_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776248 | chr19_51700139_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776249 | chr19_51700143_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776250 | chr19_51700160_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776251 | chr19_51700169_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776252 | chr19_51700175_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776253 | chr19_51700195_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776254 | chr19_51700203_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776255 | chr19_51700204_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776256 | chr19_51700233_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776257 | chr19_51700234_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776258 | chr19_51700249_+ | SINE | Alu | Name=AluSx1 |
| ADediting_776259 | chr19_51700966_+ | SINE | Alu | Name=AluSz |
| ADediting_776260 | chr19_51700967_+ | SINE | Alu | Name=AluSz |
| ADediting_776261 | chr19_51701002_+ | SINE | Alu | Name=AluSz |
| ADediting_776262 | chr19_51701072_+ | SINE | Alu | Name=AluSz |
| ADediting_776263 | chr19_51701101_+ | SINE | Alu | Name=AluSz |
| ADediting_776264 | chr19_51701123_+ | SINE | Alu | Name=AluSz |
| ADediting_776265 | chr19_51701128_+ | SINE | Alu | Name=AluSz |
| ADediting_776266 | chr19_51701137_+ | SINE | Alu | Name=AluSz |
| ADediting_776267 | chr19_51701143_+ | SINE | Alu | Name=AluSz |
| ADediting_776268 | chr19_51701938_+ | SINE | Alu | Name=AluSz |
| ADediting_776269 | chr19_51701952_+ | SINE | Alu | Name=AluSz |
| ADediting_776270 | chr19_51701965_+ | SINE | Alu | Name=AluSz |
| ADediting_776271 | chr19_51706893_+ | SINE | Alu | Name=AluSq2 |
| ADediting_776272 | chr19_51707325_+ | SINE | Alu | Name=AluSz |
| ADediting_776273 | chr19_51707338_+ | SINE | Alu | Name=AluSz |
| ADediting_776274 | chr19_51707384_+ | SINE | Alu | Name=AluSz |
| ADediting_776275 | chr19_51707474_+ | SINE | Alu | Name=AluSz |
| ADediting_776276 | chr19_51709102_+ | SINE | Alu | Name=AluJb |
| ADediting_776279 | chr19_51712086_+ | SINE | Alu | Name=AluSz |
| ADediting_1557802 | chr19_51696522_+ | SINE | Alu | Name=AluJo |
| ADediting_1557803 | chr19_51696670_+ | SINE | Alu | Name=AluJo |
| ADediting_1557804 | chr19_51699127_+ | SINE | Alu | Name=AluJr |
| ADediting_1557805 | chr19_51699155_+ | SINE | Alu | Name=AluJr |
| ADediting_1557806 | chr19_51699256_+ | SINE | Alu | Name=AluJr |
| ADediting_1557807 | chr19_51700039_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1557808 | chr19_51700044_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1557809 | chr19_51700150_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1557810 | chr19_51700156_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1557811 | chr19_51700189_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1557812 | chr19_51700236_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1557813 | chr19_51700989_+ | SINE | Alu | Name=AluSz |
| ADediting_1557814 | chr19_51701007_+ | SINE | Alu | Name=AluSz |
| ADediting_1557815 | chr19_51701095_+ | SINE | Alu | Name=AluSz |
| ADediting_1557816 | chr19_51701142_+ | SINE | Alu | Name=AluSz |
| ADediting_1557817 | chr19_51701818_+ | SINE | Alu | Name=AluSz |
| ADediting_1557818 | chr19_51701834_+ | SINE | Alu | Name=AluSz |
| ADediting_1557819 | chr19_51701939_+ | SINE | Alu | Name=AluSz |
| ADediting_1557820 | chr19_51703708_+ | SINE | Alu | Name=AluJr |
| ADediting_1557821 | chr19_51703717_+ | SINE | Alu | Name=AluJr |
Top |
RNA A-to-I editing events in the alternative splicing sites for SPACA6 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| ES | ADediting_776269 | chr19_51701952_+ | 51701947:51701969 | 3ss | 15i | TTGTAATCTCATCTACTCAGGAG | 5.71 | TTGTAGTCTCATCTACTCAGGAG | 4.54 |
| ES | ADediting_776269 | chr19_51701952_+ | 51701947:51701969 | 3ss | 15i | TTGTAATCTCATCTACTCAGGAG | 5.71 | TTGTAGTCTCATCTACTCAGGAG | 4.54 |
| ES | ADediting_776270 | chr19_51701965_+ | 51701947:51701969 | 3ss | 2i | TTGTAATCTCATCTACTCAGGAG | 5.71 | TTGTAATCTCATCTACTCGGGAG | -2.25 |
| ES | ADediting_776270 | chr19_51701965_+ | 51701947:51701969 | 3ss | 2i | TTGTAATCTCATCTACTCAGGAG | 5.71 | TTGTAATCTCATCTACTCGGGAG | -2.25 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for SPACA6 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for SPACA6 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for SPACA6 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_776279 | chr19_51712086_+ | ENSG00000182310.14 | ENST00000573896.1 | SPACA6-208 | hsa-miR-4276 | chr19 | 51712084 | 51712091 | 8mer-1a | 51712074 | 51712091 | 146 | -9.72 |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
| Differentially expressed lncRNA-miRNA network |
 |
Top |
The effects of the RNA editing to the stability of the RNA structures for SPACA6 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000573896.1 | lncRNA |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_776279 | ENST00000573896.1 | chr19_51712086_+ | 253 | -209.60 | -207.00 | -209.60 |
Top |
Relation with ADAR for SPACA6 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_776195 | chr19_51696471_+ | 0.073749307311941 | 0.101708334581682 | 0.955762497232956 | 0.00316336490489557 | 2.64220352934977e-10 | 0.348931128991379 |
| CER | ADediting_776195 | chr19_51696471_+ | 0.000613873526587292 | 0.276522808153927 | 2.24081812450456e-07 | 0.40769010771772 | 0.00127308394089426 | 0.260690183273703 |
| DLPFC | ADediting_776196 | chr19_51696479_+ | 0.155731318170433 | 0.0808210138443374 | 0.491572803427197 | 0.0392083178800645 | 2.99943055616407e-10 | 0.347915640691067 |
| DLPFC | ADediting_776197 | chr19_51696525_+ | 0.00585789375373996 | 0.156178755237933 | 0.694299261418117 | 0.022410182943088 | 7.01222155712623e-14 | 0.408246427562917 |
| CER | ADediting_776197 | chr19_51696525_+ | 0.00237327606613526 | 0.246361920388764 | 1.88408268551155e-06 | 0.37774467378367 | 0.0121016542505562 | 0.204414518607857 |
| CER | ADediting_776201 | chr19_51696548_+ | 0.00123704017430942 | 0.261332033468147 | 1.51666693067514e-05 | 0.345204240703854 | 0.453518497861161 | 0.0616590288704337 |
| CER | ADediting_776203 | chr19_51696565_+ | 0.00640495332732766 | 0.221679020010538 | 6.41586668612584e-05 | 0.320386203745999 | 0.0200133949870724 | 0.189783168858547 |
| CER | ADediting_776205 | chr19_51696574_+ | 0.0126945518285618 | 0.20306335641519 | 2.29873678107802e-05 | 0.338264148044885 | 0.0951759974508827 | 0.136752259834118 |
| CER | ADediting_776211 | chr19_51696684_+ | 0.00326100460464475 | 0.238727190396322 | 0.000120017245059068 | 0.308900712860091 | 0.704695346243418 | 0.0311978472971033 |
| CER | ADediting_776217 | chr19_51696723_+ | 0.0032213004234834 | 0.239025885384853 | 0.000131124049834263 | 0.307239075528176 | 0.822094024882079 | -0.0185124211390803 |
| CER | ADediting_776223 | chr19_51699024_+ | 4.8769589432001e-06 | 0.363345822789958 | 0.00262903509063889 | 0.243928230020842 | 0.119972031752433 | 0.127504201290123 |
| CER | ADediting_776225 | chr19_51699030_+ | 4.28075686175959e-06 | 0.365361359245215 | 0.000276282959511637 | 0.292838846831391 | 0.280260428966143 | 0.0887281955116761 |
| CER | ADediting_776226 | chr19_51699043_+ | 0.000102322054411342 | 0.311870692731047 | 1.97246904427817e-06 | 0.377066226244593 | 0.122313547770468 | 0.126710692668277 |
| CER | ADediting_776228 | chr19_51699080_+ | 1.37000164165607e-05 | 0.34687678942088 | 1.18764541556992e-05 | 0.349209849891435 | 0.000888871560943332 | 0.268607063505473 |
| CER | ADediting_776229 | chr19_51699088_+ | 8.9936426157166e-07 | 0.388482947740047 | 1.27575705211529e-06 | 0.383453852526578 | 0.0125648621508338 | 0.2033541081974 |
| CER | ADediting_776230 | chr19_51699122_+ | 9.51526297879801e-05 | 0.313212936039792 | 3.59486861019411e-07 | 0.401291884912718 | 0.0291381019039306 | 0.178190512408607 |
| CER | ADediting_776231 | chr19_51699139_+ | 0.000123883671108695 | 0.308306574837295 | 4.54208796793146e-08 | 0.428360507196342 | 0.00439044933437735 | 0.231362746437564 |
| CER | ADediting_776232 | chr19_51699143_+ | 0.00019883129464468 | 0.299287691430006 | 1.23863504616692e-06 | 0.383881882288236 | 0.000664727840786055 | 0.274840663851153 |
| CER | ADediting_776233 | chr19_51699144_+ | 0.000119535961162285 | 0.308975916024115 | 2.44784711513337e-07 | 0.406504032993408 | 0.00044530146984667 | 0.28320269847805 |
| CER | ADediting_776234 | chr19_51699149_+ | 0.00574550448588492 | 0.224505226336059 | 1.14260744033593e-06 | 0.385048497149979 | 0.232080049169283 | 0.0981581160931212 |
| CER | ADediting_776235 | chr19_51699152_+ | 0.00971752826847624 | 0.210513030932976 | 0.000124837163292414 | 0.308162716893938 | 0.884159496281195 | 0.0119961488531462 |
| CER | ADediting_776236 | chr19_51699192_+ | 0.00125181934598554 | 0.261066812018102 | 5.9622991552823e-07 | 0.394291416491286 | 0.0345473718193066 | 0.172722371549871 |
| CER | ADediting_776237 | chr19_51699218_+ | 5.45988741931649e-07 | 0.395521002500489 | 2.28223994463704e-06 | 0.374897286847558 | 0.581371195494127 | 0.045376624730012 |
| CER | ADediting_776238 | chr19_51699244_+ | 1.25020360126198e-12 | 0.537994860701349 | 1.41996634472213e-14 | 0.574964123942351 | 0.0160006636074313 | 0.196409211357891 |
| CER | ADediting_776239 | chr19_51699261_+ | 2.22029180924198e-08 | 0.437198961445488 | 4.41341693552714e-08 | 0.428720282856913 | 0.031528432950516 | 0.175676218114529 |
| TCX | ADediting_776239 | chr19_51699261_+ | 0.787488510843044 | 0.0221935188613562 | 0.894992714398042 | 0.0108674789186465 | 6.38991603085452e-05 | 0.320459036080489 |
| CER | ADediting_776247 | chr19_51700134_+ | 2.69168725251794e-05 | 0.335586532902276 | 3.86096638115904e-08 | 0.430389029966616 | 0.00277554931612905 | 0.24262902379829 |
| CER | ADediting_776250 | chr19_51700160_+ | 0.000888161319049641 | 0.268624415222873 | 1.2014563591004e-05 | 0.34902169419009 | 0.00177304284746469 | 0.253169642713896 |
| CER | ADediting_776252 | chr19_51700175_+ | 0.00845579577652716 | 0.214297499822914 | 0.000108090051588361 | 0.310853153883571 | 0.243225517939958 | 0.0958644181222156 |
| CER | ADediting_776254 | chr19_51700203_+ | 0.000393149739541073 | 0.285750469592261 | 6.47929996368653e-05 | 0.320209329070445 | 0.358785770242632 | 0.0754526773337434 |
| DLPFC | ADediting_776267 | chr19_51701143_+ | 0.369525890905683 | 0.0511399607576333 | 0.735903571355636 | -0.0192323091977717 | 8.56453059189125e-11 | 0.357797110819518 |
| CER | ADediting_776272 | chr19_51707325_+ | 0.00809193310240551 | 0.215481758708194 | 4.64115898984347e-06 | 0.364113468753097 | 0.0305383937509805 | 0.176697241100921 |
| CER | ADediting_776275 | chr19_51707474_+ | 0.0768267886191935 | 0.144919739898125 | 8.40197581596933e-05 | 0.315497329744776 | 0.241317418724007 | 0.0962518138049455 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 0.00154132478265908 | 0.17912819084065 | 0.00824062770047375 | 0.1498156723214 | 6.32039113991028e-41 | 0.664916861701465 |
| AC | 8.19903840114294e-12 | 0.414738183723919 | 8.00410681679294e-09 | 0.354672418072977 | 6.87778003441095e-14 | 0.450350319701861 |
| CER | 0.400160353534227 | 0.0691911449480106 | 1.76773364220734e-06 | 0.378685453306525 | 0.412729758194764 | 0.0673667118040339 |
| FP | 0.00136913941747811 | 0.23814728186338 | 0.00344672156684057 | 0.218114369938461 | 1.63936579592671e-10 | 0.455710017692039 |
| IFG | 0.0420162983633002 | 0.40960100162238 | 0.0116451309590189 | 0.496188452367441 | 0.000764226343422989 | 0.628619233882429 |
| STG | 0.00298731940741218 | 0.320172687857261 | 0.0869553784260041 | 0.187907791541602 | 9.32472411205022e-07 | 0.505584838774464 |
Top |
Relation with AD stages for SPACA6 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_776203 | chr19_51696565_+ | 0.000110001408553688 | 0.363553798443059 |
| CER | ADediting_776205 | chr19_51696574_+ | 0.000122891920703268 | 0.361179455198186 |
| CER | ADediting_776232 | chr19_51699143_+ | 0.000666185239126528 | 0.322427029751108 |
| CER | ADediting_776233 | chr19_51699144_+ | 0.0014798978738773 | 0.302192867675656 |
| CER | ADediting_776238 | chr19_51699244_+ | 0.000815674452311062 | 0.317426698734621 |
| CER | ADediting_776247 | chr19_51700134_+ | 0.000515979499896921 | 0.328618443000223 |
| CER | ADediting_776249 | chr19_51700143_+ | 0.00116754774874829 | 0.308351858380605 |
| CER | ADediting_776250 | chr19_51700160_+ | 0.000139670573794321 | 0.358413941699046 |
| CER | ADediting_776263 | chr19_51701101_+ | 2.72899293971142e-05 | 0.391948613682155 |
| CER | ADediting_776265 | chr19_51701128_+ | 0.000809060342195076 | 0.317629457233808 |
| CER | ADediting_776269 | chr19_51701952_+ | 8.7911882252754e-05 | 0.368300923734585 |
| CER | ADediting_1557808 | chr19_51700044_+ | 0.000452881861980141 | 0.331729786008333 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| AC | 1.2002140360762e-06 | 0.301433228952396 |
| CER | 4.81492638356238e-05 | 0.380697508586123 |
Top |
RelatedDrugs for SPACA6 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SPACA6 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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