ADeditome: functional annotation of RNA A-to-I editing in AD

Gene summary for LRRC37BP1

Gene summary

Gene information	Gene symbol	LRRC37BP1
	Gene ID	147172
	Gene name	leucine rich repeat containing 37B pseudogene 1
	Synonyms	LRRC37B2
	Cytomap	17q11.2
	Type of gene	pseudo
	Description	LRRC37B pseudogene 1leucine rich repeat containing 37, member B2putative LRRC37B-like protein 2
	Modification date	20200313
	UniProtAcc
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for LRRC37BP1

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_605884(30633742, +), ADediting_605885(30633805, +), ADediting_605886(30635244, +), ADediting_605887(30635256, +), ADediting_605888(30635261, +), ADediting_605889(30635301, +), ADediting_605890(30635304, +), ADediting_605891(30635305, +), ADediting_605892(30635306, +), ADediting_605893(30635307, +), ADediting_605894(30635308, +), ADediting_605895(30635315, +), ADediting_605896(30635316, +), ADediting_605897(30635317, +), ADediting_605898(30635320, +), ADediting_605899(30635370, +), ADediting_605900(30635373, +), ADediting_605901(30635417, +), ADediting_605902(30636201, +), ADediting_605903(30636212, +), ADediting_605904(30636218, +), ADediting_605905(30636230, +), ADediting_605906(30636235, +), ADediting_605907(30636241, +), ADediting_605908(30636247, +), ADediting_605909(30636261, +), ADediting_605910(30636278, +), ADediting_605911(30636334, +), ADediting_605912(30636340, +), ADediting_605913(30636341, +), ADediting_605914(30636343, +), ADediting_605915(30636721, +), ADediting_605916(30636800, +), ADediting_605917(30636815, +), ADediting_605918(30636831, +), ADediting_605919(30636841, +), ADediting_605920(30636897, +), ADediting_1545952(30635240, +),

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RNA editing positional annotations for LRRC37BP1 using Annovar

Protein coding RNA editing(s).

ADeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_605884	chr17_30633742_+	ncRNA_intronic
ADediting_605885	chr17_30633805_+	ncRNA_intronic
ADediting_605886	chr17_30635244_+	ncRNA_exonic
ADediting_605887	chr17_30635256_+	ncRNA_exonic
ADediting_605888	chr17_30635261_+	ncRNA_exonic
ADediting_605889	chr17_30635301_+	ncRNA_exonic
ADediting_605890	chr17_30635304_+	ncRNA_exonic
ADediting_605891	chr17_30635305_+	ncRNA_exonic
ADediting_605892	chr17_30635306_+	ncRNA_exonic
ADediting_605893	chr17_30635307_+	ncRNA_exonic
ADediting_605894	chr17_30635308_+	ncRNA_exonic
ADediting_605895	chr17_30635315_+	ncRNA_exonic
ADediting_605896	chr17_30635316_+	ncRNA_exonic
ADediting_605897	chr17_30635317_+	ncRNA_exonic
ADediting_605898	chr17_30635320_+	ncRNA_exonic
ADediting_605899	chr17_30635370_+	ncRNA_exonic
ADediting_605900	chr17_30635373_+	ncRNA_exonic
ADediting_605901	chr17_30635417_+	ncRNA_exonic
ADediting_605902	chr17_30636201_+	ncRNA_exonic
ADediting_605903	chr17_30636212_+	ncRNA_exonic
ADediting_605904	chr17_30636218_+	ncRNA_exonic
ADediting_605905	chr17_30636230_+	ncRNA_exonic
ADediting_605906	chr17_30636235_+	ncRNA_exonic
ADediting_605907	chr17_30636241_+	ncRNA_exonic
ADediting_605908	chr17_30636247_+	ncRNA_exonic
ADediting_605909	chr17_30636261_+	ncRNA_exonic
ADediting_605910	chr17_30636278_+	ncRNA_exonic
ADediting_605911	chr17_30636334_+	ncRNA_exonic
ADediting_605912	chr17_30636340_+	ncRNA_exonic
ADediting_605913	chr17_30636341_+	ncRNA_exonic
ADediting_605914	chr17_30636343_+	ncRNA_exonic
ADediting_605915	chr17_30636721_+	ncRNA_exonic
ADediting_605916	chr17_30636800_+	ncRNA_exonic
ADediting_605917	chr17_30636815_+	ncRNA_exonic
ADediting_605918	chr17_30636831_+	ncRNA_exonic
ADediting_605919	chr17_30636841_+	ncRNA_exonic
ADediting_605920	chr17_30636897_+	ncRNA_exonic
ADediting_1545952	chr17_30635240_+	ncRNA_exonic

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_605884	chr17_30633742_+	SINE	Alu	Name=AluJb
ADediting_605885	chr17_30633805_+	SINE	Alu	Name=AluJb
ADediting_605886	chr17_30635244_+	SINE	Alu	Name=AluY
ADediting_605887	chr17_30635256_+	SINE	Alu	Name=AluY
ADediting_605888	chr17_30635261_+	SINE	Alu	Name=AluY
ADediting_605889	chr17_30635301_+	SINE	Alu	Name=AluY
ADediting_605890	chr17_30635304_+	SINE	Alu	Name=AluY
ADediting_605891	chr17_30635305_+	SINE	Alu	Name=AluY
ADediting_605892	chr17_30635306_+	SINE	Alu	Name=AluY
ADediting_605893	chr17_30635307_+	SINE	Alu	Name=AluY
ADediting_605894	chr17_30635308_+	SINE	Alu	Name=AluY
ADediting_605895	chr17_30635315_+	SINE	Alu	Name=AluY
ADediting_605896	chr17_30635316_+	SINE	Alu	Name=AluY
ADediting_605897	chr17_30635317_+	SINE	Alu	Name=AluY
ADediting_605898	chr17_30635320_+	SINE	Alu	Name=AluY
ADediting_605899	chr17_30635370_+	SINE	Alu	Name=AluY
ADediting_605900	chr17_30635373_+	SINE	Alu	Name=AluY
ADediting_605901	chr17_30635417_+	SINE	Alu	Name=AluY
ADediting_605902	chr17_30636201_+	SINE	Alu	Name=AluJr4
ADediting_605903	chr17_30636212_+	SINE	Alu	Name=AluJr4
ADediting_605904	chr17_30636218_+	SINE	Alu	Name=AluJr4
ADediting_605905	chr17_30636230_+	SINE	Alu	Name=AluJr4
ADediting_605906	chr17_30636235_+	SINE	Alu	Name=AluJr4
ADediting_605907	chr17_30636241_+	SINE	Alu	Name=AluJr4
ADediting_605908	chr17_30636247_+	SINE	Alu	Name=AluJr4
ADediting_605909	chr17_30636261_+	SINE	Alu	Name=AluJr4
ADediting_605910	chr17_30636278_+	SINE	Alu	Name=AluJr4
ADediting_605911	chr17_30636334_+	SINE	Alu	Name=AluJr4
ADediting_605912	chr17_30636340_+	SINE	Alu	Name=AluJr4
ADediting_605913	chr17_30636341_+	SINE	Alu	Name=AluJr4
ADediting_605914	chr17_30636343_+	SINE	Alu	Name=AluJr4
ADediting_605915	chr17_30636721_+	SINE	Alu	Name=AluJr
ADediting_605916	chr17_30636800_+	SINE	Alu	Name=AluJr
ADediting_605917	chr17_30636815_+	SINE	Alu	Name=AluJr
ADediting_605918	chr17_30636831_+	SINE	Alu	Name=AluJr
ADediting_605919	chr17_30636841_+	SINE	Alu	Name=AluJr
ADediting_605920	chr17_30636897_+	SINE	Alu	Name=AluJr
ADediting_1545952	chr17_30635240_+	SINE	Alu	Name=AluY

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RNA A-to-I editing events in the alternative splicing sites for LRRC37BP1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

ADeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for LRRC37BP1

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

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Protein coding region RNA A-to-I editings for LRRC37BP1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for LRRC37BP1

RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1545952	chr17_30635240_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-18a-3p	chr17	30635239	30635245	7mer-m8	30635226	30635246	147	-21.43
ADediting_1545952	chr17_30635240_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-3176	chr17	30635234	30635240	7mer-m8	30635223	30635241	140	-15.24
ADediting_1545952	chr17_30635240_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-3922-3p	chr17	30635234	30635240	7mer-m8	30635220	30635241	141	-19.73
ADediting_1545952	chr17_30635240_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-874-3p	chr17	30635238	30635244	7mer-m8	30635222	30635245	156	-31.64
ADediting_605886	chr17_30635244_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-4707-3p	chr17	30635241	30635247	7mer-m8	30635223	30635248	150	-27.2
ADediting_605887	chr17_30635256_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-10a-5p	chr17	30635253	30635259	7mer-m8	30635239	30635260	161	-26.72
ADediting_605887	chr17_30635256_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-10b-5p	chr17	30635253	30635259	7mer-m8	30635239	30635260	153	-21.93
ADediting_605887	chr17_30635256_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-146b-3p	chr17	30635252	30635258	7mer-m8	30635236	30635259	147	-22.36
ADediting_605887	chr17_30635256_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-4679	chr17	30635250	30635256	7mer-m8	30635236	30635257	148	-16.73
ADediting_605887	chr17_30635256_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-4725-5p	chr17	30635254	30635261	8mer-1a	30635237	30635261	148	-21.43
ADediting_605887	chr17_30635256_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-504-5p	chr17	30635254	30635261	8mer-1a	30635239	30635261	150	-23.23
ADediting_605889	chr17_30635301_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-374b-3p	chr17	30635299	30635306	8mer-1a	30635287	30635306	144	-9.44
ADediting_605889	chr17_30635301_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-3919	chr17	30635295	30635301	7mer-m8	30635282	30635302	140	-13.54
ADediting_605890	chr17_30635304_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-222-5p	chr17	30635299	30635306	8mer-1a	30635285	30635306	150	-11.94
ADediting_605890	chr17_30635304_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-30a-3p	chr17	30635301	30635308	8mer-1a	30635284	30635308	152	-14.65
ADediting_605890	chr17_30635304_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-30d-3p	chr17	30635301	30635308	8mer-1a	30635284	30635308	151	-14.89
ADediting_605890	chr17_30635304_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-30e-3p	chr17	30635301	30635308	8mer-1a	30635285	30635308	148	-10.42
ADediting_605890	chr17_30635304_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-936	chr17	30635298	30635305	8mer-1a	30635284	30635305	154	-19.42
ADediting_605891	chr17_30635305_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-325	chr17	30635299	30635306	8mer-1a	30635284	30635306	141	-15.57
ADediting_605894	chr17_30635308_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-4325	chr17	30635306	30635313	8mer-1a	30635296	30635313	143	-12.13
ADediting_605899	chr17_30635370_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-6747-3p	chr17	30635369	30635376	8mer-1a	30635357	30635376	152	-23.28
ADediting_605901	chr17_30635417_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-3064-5p	chr17	30635411	30635417	7mer-m8	30635400	30635418	152	-20.19
ADediting_605901	chr17_30635417_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-6504-5p	chr17	30635411	30635417	7mer-m8	30635400	30635418	163	-28.15
ADediting_605902	chr17_30636201_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-1273c	chr17	30636196	30636202	7mer-m8	30636184	30636203	165	-30
ADediting_605902	chr17_30636201_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-4486	chr17	30636200	30636207	8mer-1a	30636190	30636207	146	-22.53
ADediting_605903	chr17_30636212_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-2355-5p	chr17	30636208	30636214	7mer-m8	30636195	30636215	140	-18.8
ADediting_605903	chr17_30636212_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-6772-3p	chr17	30636212	30636218	7mer-1a	30636196	30636218	145	-18.88
ADediting_605904	chr17_30636218_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-324-3p	chr17	30636215	30636221	7mer-m8	30636200	30636222	152	-26.27
ADediting_605905	chr17_30636230_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-1288-5p	chr17	30636224	30636230	7mer-m8	30636210	30636231	154	-16.69
ADediting_605905	chr17_30636230_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-6807-5p	chr17	30636229	30636235	7mer-m8	30636215	30636236	145	-18.44
ADediting_605907	chr17_30636241_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-139-5p	chr17	30636235	30636241	7mer-m8	30636217	30636242	147	-17.32
ADediting_605907	chr17_30636241_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-3975	chr17	30636239	30636246	8mer-1a	30636223	30636246	150	-20
ADediting_605907	chr17_30636241_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-548v	chr17	30636236	30636242	7mer-m8	30636219	30636243	155	-20.22
ADediting_605908	chr17_30636247_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-12119	chr17	30636242	30636248	7mer-m8	30636226	30636249	165	-26.13
ADediting_605908	chr17_30636247_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-4294	chr17	30636246	30636252	7mer-m8	30636237	30636253	140	-14.98
ADediting_605908	chr17_30636247_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-7162-3p	chr17	30636241	30636248	8mer-1a	30636232	30636248	144	-19.87
ADediting_605913	chr17_30636341_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-4421	chr17	30636336	30636343	8mer-1a	30636321	30636343	150	-19.61
ADediting_605913	chr17_30636341_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-5699-3p	chr17	30636336	30636343	8mer-1a	30636322	30636343	148	-18.5
ADediting_605915	chr17_30636721_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-3176	chr17	30636715	30636721	7mer-m8	30636704	30636722	140	-15.08
ADediting_605915	chr17_30636721_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-3922-3p	chr17	30636715	30636721	7mer-m8	30636701	30636722	141	-17.36
ADediting_605916	chr17_30636800_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-140-3p	chr17	30636796	30636802	7mer-m8	30636780	30636803	161	-28.1
ADediting_605917	chr17_30636815_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-1200	chr17	30636811	30636817	7mer-m8	30636797	30636818	141	-18.61
ADediting_605917	chr17_30636815_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-660-3p	chr17	30636813	30636819	7mer-m8	30636799	30636820	158	-24.94
ADediting_605917	chr17_30636815_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-6791-3p	chr17	30636814	30636820	7mer-m8	30636801	30636821	154	-17.64
ADediting_605917	chr17_30636815_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-6829-3p	chr17	30636814	30636820	7mer-m8	30636802	30636821	155	-20.58
ADediting_605919	chr17_30636841_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-296-5p	chr17	30636839	30636846	8mer-1a	30636826	30636846	140	-18.54
ADediting_605919	chr17_30636841_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-6724-5p	chr17	30636840	30636846	7mer-m8	30636827	30636847	148	-26.82
ADediting_605919	chr17_30636841_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-6773-5p	chr17	30636840	30636846	7mer-m8	30636825	30636847	145	-20.7
ADediting_605919	chr17_30636841_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-874-5p	chr17	30636838	30636844	7mer-m8	30636823	30636845	140	-20.11
ADediting_605920	chr17_30636897_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-500b-3p	chr17	30636894	30636901	8mer-1a	30636883	30636901	153	-22.37
ADediting_605920	chr17_30636897_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-6879-3p	chr17	30636896	30636903	8mer-1a	30636881	30636903	142	-19.91

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_605886	chr17_30635244_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-4485-5p	chr17	30635243	30635250	8mer-1a	30635235	30635250	150	-21.37
ADediting_605886	chr17_30635244_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-6747-3p	chr17	30635240	30635246	7mer-m8	30635226	30635247	154	-22.42
ADediting_605888	chr17_30635261_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-378a-5p	chr17	30635258	30635264	7mer-m8	30635243	30635265	148	-23.87
ADediting_605889	chr17_30635301_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-6832-5p	chr17	30635296	30635302	7mer-m8	30635281	30635303	141	-17.84
ADediting_605891	chr17_30635305_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-153-5p	chr17	30635304	30635310	7mer-m8	30635288	30635311	147	-7.78
ADediting_605892	chr17_30635306_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-153-5p	chr17	30635304	30635310	7mer-m8	30635288	30635311	147	-7.78
ADediting_605893	chr17_30635307_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-153-5p	chr17	30635304	30635310	7mer-m8	30635288	30635311	147	-7.78
ADediting_605894	chr17_30635308_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-153-5p	chr17	30635304	30635310	7mer-m8	30635288	30635311	147	-7.78
ADediting_605895	chr17_30635315_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-129-5p	chr17	30635310	30635317	8mer-1a	30635297	30635317	148	-8.42
ADediting_605895	chr17_30635315_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-9983-3p	chr17	30635310	30635317	8mer-1a	30635296	30635317	140	-7.68
ADediting_605896	chr17_30635316_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-129-5p	chr17	30635310	30635317	8mer-1a	30635297	30635317	148	-8.42
ADediting_605896	chr17_30635316_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-4735-5p	chr17	30635315	30635321	7mer-m8	30635301	30635322	140	-5.85
ADediting_605896	chr17_30635316_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-9983-3p	chr17	30635310	30635317	8mer-1a	30635296	30635317	140	-7.68
ADediting_605897	chr17_30635317_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-4735-5p	chr17	30635315	30635321	7mer-m8	30635301	30635322	140	-5.85
ADediting_605898	chr17_30635320_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-4735-5p	chr17	30635315	30635321	7mer-m8	30635301	30635322	140	-5.85
ADediting_605899	chr17_30635370_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-3977	chr17	30635367	30635373	7mer-m8	30635349	30635374	154	-11.33
ADediting_605900	chr17_30635373_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-3074-5p	chr17	30635371	30635378	8mer-1a	30635362	30635378	146	-18.63
ADediting_605900	chr17_30635373_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-3977	chr17	30635367	30635373	7mer-m8	30635349	30635374	154	-11.33
ADediting_605902	chr17_30636201_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-1262	chr17	30636199	30636205	7mer-m8	30636185	30636206	140	-16.95
ADediting_605902	chr17_30636201_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-4504	chr17	30636196	30636202	7mer-m8	30636182	30636203	149	-15.22
ADediting_605902	chr17_30636201_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-4701-3p	chr17	30636199	30636205	7mer-m8	30636188	30636206	144	-15.22
ADediting_605902	chr17_30636201_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-6736-5p	chr17	30636199	30636205	7mer-m8	30636186	30636206	149	-23.16
ADediting_605902	chr17_30636201_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-6776-5p	chr17	30636200	30636207	8mer-1a	30636188	30636207	155	-25.9
ADediting_605903	chr17_30636212_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-3925-3p	chr17	30636207	30636214	8mer-1a	30636194	30636214	150	-14.63
ADediting_605907	chr17_30636241_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-655-5p	chr17	30636239	30636246	8mer-1a	30636224	30636246	149	-12.65
ADediting_605909	chr17_30636261_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-188-5p	chr17	30636260	30636266	7mer-m8	30636247	30636267	147	-17.94
ADediting_605909	chr17_30636261_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-6866-3p	chr17	30636260	30636266	7mer-m8	30636246	30636267	145	-19.79
ADediting_605910	chr17_30636278_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-4649-3p	chr17	30636273	30636279	7mer-m8	30636260	30636280	147	-20.55
ADediting_605910	chr17_30636278_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-7160-5p	chr17	30636274	30636280	7mer-m8	30636261	30636281	146	-20.9
ADediting_605911	chr17_30636334_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-4684-5p	chr17	30636332	30636338	7mer-m8	30636318	30636339	140	-8.32
ADediting_605911	chr17_30636334_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-519a-2-5p	chr17	30636331	30636338	8mer-1a	30636319	30636338	149	-12.28
ADediting_605911	chr17_30636334_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-520b-5p	chr17	30636331	30636338	8mer-1a	30636319	30636338	149	-12.28
ADediting_605912	chr17_30636340_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-6818-3p	chr17	30636334	30636341	8mer-1a	30636320	30636341	140	-14.59
ADediting_605913	chr17_30636341_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-7161-3p	chr17	30636340	30636346	7mer-m8	30636322	30636347	155	-17.99
ADediting_605914	chr17_30636343_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-3156-5p	chr17	30636341	30636347	7mer-m8	30636327	30636348	142	-8.27
ADediting_605914	chr17_30636343_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-7161-3p	chr17	30636340	30636346	7mer-m8	30636322	30636347	155	-17.99
ADediting_605916	chr17_30636800_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-8052	chr17	30636800	30636806	7mer-1a	30636786	30636806	149	-22.85
ADediting_605917	chr17_30636815_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-2682-3p	chr17	30636814	30636820	7mer-m8	30636799	30636821	155	-17.04
ADediting_605917	chr17_30636815_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-526b-5p	chr17	30636811	30636817	7mer-m8	30636796	30636818	140	-18.34
ADediting_605917	chr17_30636815_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-6781-3p	chr17	30636814	30636820	7mer-m8	30636800	30636821	140	-11.15
ADediting_605919	chr17_30636841_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-10400-3p	chr17	30636840	30636846	7mer-m8	30636825	30636847	148	-23.72
ADediting_605919	chr17_30636841_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-3925-3p	chr17	30636836	30636842	7mer-m8	30636822	30636843	146	-17
ADediting_605919	chr17_30636841_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-4674	chr17	30636840	30636846	7mer-m8	30636827	30636847	143	-21.73
ADediting_605920	chr17_30636897_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-510-5p	chr17	30636893	30636899	7mer-m8	30636878	30636900	148	-20.87
ADediting_605920	chr17_30636897_+	ENSG00000250462.8	ENST00000417404.2	LRRC37BP1-203	hsa-miR-668-3p	chr17	30636896	30636903	8mer-1a	30636879	30636903	155	-24.14

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for LRRC37BP1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000417404.2	lncRNA

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID

ENST

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in lncRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_1545952	ENST00000417404.2	chr17_30635240_+	2516	-1436.40	-1434.80	-1493.10
ADediting_605886	ENST00000417404.2	chr17_30635244_+	2520	-1435.40	-1434.80	-1493.10
ADediting_605887	ENST00000417404.2	chr17_30635256_+	2532	-1434.90	-1434.80	-1493.10
ADediting_605888	ENST00000417404.2	chr17_30635261_+	2537	-1434.10	-1434.80	-1493.10
ADediting_605889	ENST00000417404.2	chr17_30635301_+	2577	-1438.10	-1434.80	-1493.10
ADediting_605890	ENST00000417404.2	chr17_30635304_+	2580	-1435.90	-1434.80	-1493.10
ADediting_605891	ENST00000417404.2	chr17_30635305_+	2581	-1434.60	-1434.80	-1493.10
ADediting_605892	ENST00000417404.2	chr17_30635306_+	2582	-1438.20	-1434.80	-1493.10
ADediting_605893	ENST00000417404.2	chr17_30635307_+	2583	-1434.80	-1434.80	-1493.10
ADediting_605894	ENST00000417404.2	chr17_30635308_+	2584	-1434.80	-1434.80	-1493.10
ADediting_605895	ENST00000417404.2	chr17_30635315_+	2591	-1435.50	-1434.80	-1493.10
ADediting_605896	ENST00000417404.2	chr17_30635316_+	2592	-1435.80	-1434.80	-1493.10
ADediting_605897	ENST00000417404.2	chr17_30635317_+	2593	-1435.70	-1434.80	-1493.10
ADediting_605898	ENST00000417404.2	chr17_30635320_+	2596	-1434.50	-1434.80	-1493.10
ADediting_605899	ENST00000417404.2	chr17_30635370_+	2646	-1441.40	-1434.80	-1493.10
ADediting_605900	ENST00000417404.2	chr17_30635373_+	2649	-1434.30	-1434.80	-1493.10
ADediting_605901	ENST00000417404.2	chr17_30635417_+	2693	-1434.90	-1434.80	-1493.10
ADediting_605902	ENST00000417404.2	chr17_30636201_+	3477	-1434.40	-1434.80	-1493.10
ADediting_605903	ENST00000417404.2	chr17_30636212_+	3488	-1433.90	-1434.80	-1493.10
ADediting_605904	ENST00000417404.2	chr17_30636218_+	3494	-1440.90	-1434.80	-1493.10
ADediting_605905	ENST00000417404.2	chr17_30636230_+	3506	-1433.50	-1434.80	-1493.10
ADediting_605906	ENST00000417404.2	chr17_30636235_+	3511	-1434.40	-1434.80	-1493.10
ADediting_605907	ENST00000417404.2	chr17_30636241_+	3517	-1441.50	-1434.80	-1493.10
ADediting_605908	ENST00000417404.2	chr17_30636247_+	3523	-1434.80	-1434.80	-1493.10
ADediting_605909	ENST00000417404.2	chr17_30636261_+	3537	-1434.80	-1434.80	-1493.10
ADediting_605910	ENST00000417404.2	chr17_30636278_+	3554	-1434.10	-1434.80	-1493.10
ADediting_605911	ENST00000417404.2	chr17_30636334_+	3610	-1434.40	-1434.80	-1493.10
ADediting_605912	ENST00000417404.2	chr17_30636340_+	3616	-1434.50	-1434.80	-1493.10
ADediting_605913	ENST00000417404.2	chr17_30636341_+	3617	-1434.50	-1434.80	-1493.10
ADediting_605914	ENST00000417404.2	chr17_30636343_+	3619	-1441.50	-1434.80	-1493.10
ADediting_605915	ENST00000417404.2	chr17_30636721_+	3997	-1441.50	-1434.80	-1493.10
ADediting_605916	ENST00000417404.2	chr17_30636800_+	4076	-1434.50	-1434.80	-1493.10
ADediting_605917	ENST00000417404.2	chr17_30636815_+	4091	-1441.40	-1434.80	-1493.10
ADediting_605918	ENST00000417404.2	chr17_30636831_+	4107	-1439.20	-1434.80	-1493.10
ADediting_605919	ENST00000417404.2	chr17_30636841_+	4117	-1434.00	-1434.80	-1493.10
ADediting_605920	ENST00000417404.2	chr17_30636897_+	4173	-1441.70	-1434.80	-1493.10

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Relation with ADAR for LRRC37BP1

Correlation between ADAR gene expression and RNA editing frequency

Tissue

ADeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	8.32416268203159e-36	0.630821260937634	9.28440934963826e-38	0.644344016501083	2.55041625982537e-13	0.399699924663226
AC	4.33592348329079e-103	0.920333243159371	4.74461461740955e-64	0.827293943803279	2.00830630970251e-15	0.474236467059712
PCC	6.87250878670621e-24	0.645411233990634	3.81217659712786e-20	0.60107792734452	1.30774862468932e-05	0.309638541484958
CER	2.75418634400525e-37	0.817479414187748	4.79918719353713e-29	0.756139484590193	0.0142152336600585	0.199835056745822
TCX	7.23092457522587e-23	0.693947342456866	8.2540181182218e-07	0.389704791078413	1.97890743929385e-10	0.489921978563572
FP	5.71079440743186e-28	0.70413830764907	1.44947794166998e-19	0.610564664991747	1.867692503885e-07	0.378679897496753
IFG	0.0263487485643871	0.443575760344081	0.00223473707859579	0.582779112462506	0.0407541905438932	0.411922055267516
PG	8.54746879122479e-27	0.681999611401531	3.17446255064497e-21	0.621066038744894	0.165872614723611	0.102018737352862
STG	5.80041349392263e-07	0.513732773630806	0.000350614253051876	0.380926549539753	0.000733778704430904	0.361305944967603

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Relation with AD stages for LRRC37BP1

Correlation between AD stages and RNA editing frequency

Tissue

ADeditomID

position

P-val

Coeff.

Correlation between AD stages and this gene's expression

Tissue	P-val	Coeff.
CER	0.00147714695287399	0.302241723802681
TCX	1.56650547369223e-06	0.446927240171155

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RelatedDrugs for LRRC37BP1

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for LRRC37BP1

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

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Statistics

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Gene summary for LRRC37BP1

RNA A-to-I events for LRRC37BP1

RNA editing positional annotations for LRRC37BP1 using Annovar

RNA A-to-I editing events in the alternative splicing sites for LRRC37BP1

Differntial gene expression between RNA A-to-I edited versus non-edited samples for LRRC37BP1

Protein coding region RNA A-to-I editings for LRRC37BP1

The effects of the RNA editing to the miRNA binding sites for LRRC37BP1

The effects of the RNA editing to the stability of the RNA structures for LRRC37BP1

Relation with ADAR for LRRC37BP1

Relation with AD stages for LRRC37BP1

RelatedDrugs for LRRC37BP1

RelatedDiseases for LRRC37BP1

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene