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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for FBXL16 |
 Gene summary |
| Gene information | Gene symbol | FBXL16 | Gene ID | 146330 |
| Gene name | F-box and leucine rich repeat protein 16 | |
| Synonyms | C16orf22|Fbl16|c380A1.1 | |
| Cytomap | 16p13.3 | |
| Type of gene | protein-coding | |
| Description | F-box/LRR-repeat protein 16c380A1.1 (novel protein) | |
| Modification date | 20200313 | |
| UniProtAcc | Q8N461, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for FBXL16 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_563377(697742, -), ADediting_563379(697744, -), ADediting_563384(697756, -), ADediting_563385(697807, -), ADediting_563386(697811, -), ADediting_563391(697836, -), ADediting_563392(697842, -), ADediting_563393(697856, -), ADediting_563394(697876, -), ADediting_563395(697888, -), ADediting_563403(698070, -), ADediting_563417(698089, -), ADediting_563438(698106, -), ADediting_563441(698109, -), ADediting_563443(698115, -), ADediting_563444(698125, -), ADediting_563445(698132, -), ADediting_563446(698136, -), ADediting_563459(698168, -), ADediting_563461(698176, -), ADediting_563467(698230, -), ADediting_563485(698267, -), ADediting_563486(698270, -), ADediting_563487(698275, -), ADediting_563488(698276, -), ADediting_563489(698278, -), ADediting_563511(698298, -), ADediting_563512(698310, -), ADediting_563513(698311, -), ADediting_563610(698658, -), ADediting_563611(698660, -), ADediting_563612(698666, -), ADediting_563613(698672, -), ADediting_563614(698722, -), ADediting_563616(698731, -), ADediting_563617(698734, -), ADediting_563618(698743, -), ADediting_563619(698748, -), ADediting_563620(698751, -), ADediting_563621(698757, -), ADediting_563622(698765, -), ADediting_563623(698766, -), ADediting_563624(698775, -), ADediting_563625(698776, -), ADediting_563626(698790, -), ADediting_563627(698831, -), ADediting_563628(698832, -), ADediting_563631(698878, -), ADediting_565093(703917, -), ADediting_565597(704606, -), ADediting_1543903(698682, -), |
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RNA editing positional annotations for FBXL16 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_563377 | chr16_697742_- | intronic |
| ADediting_563379 | chr16_697744_- | intronic |
| ADediting_563384 | chr16_697756_- | intronic |
| ADediting_563385 | chr16_697807_- | intronic |
| ADediting_563386 | chr16_697811_- | intronic |
| ADediting_563391 | chr16_697836_- | intronic |
| ADediting_563392 | chr16_697842_- | intronic |
| ADediting_563393 | chr16_697856_- | intronic |
| ADediting_563394 | chr16_697876_- | intronic |
| ADediting_563395 | chr16_697888_- | intronic |
| ADediting_563403 | chr16_698070_- | intronic |
| ADediting_563417 | chr16_698089_- | intronic |
| ADediting_563438 | chr16_698106_- | intronic |
| ADediting_563441 | chr16_698109_- | intronic |
| ADediting_563443 | chr16_698115_- | intronic |
| ADediting_563444 | chr16_698125_- | intronic |
| ADediting_563445 | chr16_698132_- | intronic |
| ADediting_563446 | chr16_698136_- | intronic |
| ADediting_563459 | chr16_698168_- | intronic |
| ADediting_563461 | chr16_698176_- | intronic |
| ADediting_563467 | chr16_698230_- | intronic |
| ADediting_563485 | chr16_698267_- | intronic |
| ADediting_563486 | chr16_698270_- | intronic |
| ADediting_563487 | chr16_698275_- | intronic |
| ADediting_563488 | chr16_698276_- | intronic |
| ADediting_563489 | chr16_698278_- | intronic |
| ADediting_563511 | chr16_698298_- | intronic |
| ADediting_563512 | chr16_698310_- | intronic |
| ADediting_563513 | chr16_698311_- | intronic |
| ADediting_563610 | chr16_698658_- | intronic |
| ADediting_563611 | chr16_698660_- | intronic |
| ADediting_563612 | chr16_698666_- | intronic |
| ADediting_563613 | chr16_698672_- | intronic |
| ADediting_563614 | chr16_698722_- | intronic |
| ADediting_563616 | chr16_698731_- | intronic |
| ADediting_563617 | chr16_698734_- | intronic |
| ADediting_563618 | chr16_698743_- | intronic |
| ADediting_563619 | chr16_698748_- | intronic |
| ADediting_563620 | chr16_698751_- | intronic |
| ADediting_563621 | chr16_698757_- | intronic |
| ADediting_563622 | chr16_698765_- | intronic |
| ADediting_563623 | chr16_698766_- | intronic |
| ADediting_563624 | chr16_698775_- | intronic |
| ADediting_563625 | chr16_698776_- | intronic |
| ADediting_563626 | chr16_698790_- | intronic |
| ADediting_563627 | chr16_698831_- | intronic |
| ADediting_563628 | chr16_698832_- | intronic |
| ADediting_563631 | chr16_698878_- | intronic |
| ADediting_565093 | chr16_703917_- | intronic |
| ADediting_565597 | chr16_704606_- | intronic |
| ADediting_1543903 | chr16_698682_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_563377 | chr16_697742_- | SINE | Alu | Name=AluY |
| ADediting_563379 | chr16_697744_- | SINE | Alu | Name=AluY |
| ADediting_563384 | chr16_697756_- | SINE | Alu | Name=AluY |
| ADediting_563385 | chr16_697807_- | SINE | Alu | Name=AluY |
| ADediting_563386 | chr16_697811_- | SINE | Alu | Name=AluY |
| ADediting_563391 | chr16_697836_- | SINE | Alu | Name=AluY |
| ADediting_563392 | chr16_697842_- | SINE | Alu | Name=AluY |
| ADediting_563393 | chr16_697856_- | SINE | Alu | Name=AluY |
| ADediting_563394 | chr16_697876_- | SINE | Alu | Name=AluY |
| ADediting_563395 | chr16_697888_- | SINE | Alu | Name=AluY |
| ADediting_563403 | chr16_698070_- | SINE | Alu | Name=AluSp |
| ADediting_563417 | chr16_698089_- | SINE | Alu | Name=AluSp |
| ADediting_563438 | chr16_698106_- | SINE | Alu | Name=AluSp |
| ADediting_563441 | chr16_698109_- | SINE | Alu | Name=AluSp |
| ADediting_563443 | chr16_698115_- | SINE | Alu | Name=AluSp |
| ADediting_563444 | chr16_698125_- | SINE | Alu | Name=AluSp |
| ADediting_563445 | chr16_698132_- | SINE | Alu | Name=AluSp |
| ADediting_563446 | chr16_698136_- | SINE | Alu | Name=AluSp |
| ADediting_563459 | chr16_698168_- | SINE | Alu | Name=AluSp |
| ADediting_563461 | chr16_698176_- | SINE | Alu | Name=AluSp |
| ADediting_563467 | chr16_698230_- | SINE | Alu | Name=AluSp |
| ADediting_563485 | chr16_698267_- | SINE | Alu | Name=AluSp |
| ADediting_563486 | chr16_698270_- | SINE | Alu | Name=AluSp |
| ADediting_563487 | chr16_698275_- | SINE | Alu | Name=AluSp |
| ADediting_563488 | chr16_698276_- | SINE | Alu | Name=AluSp |
| ADediting_563489 | chr16_698278_- | SINE | Alu | Name=AluSp |
| ADediting_563511 | chr16_698298_- | SINE | Alu | Name=AluSp |
| ADediting_563610 | chr16_698658_- | SINE | Alu | Name=AluSg |
| ADediting_563611 | chr16_698660_- | SINE | Alu | Name=AluSg |
| ADediting_563612 | chr16_698666_- | SINE | Alu | Name=AluSg |
| ADediting_563613 | chr16_698672_- | SINE | Alu | Name=AluSg |
| ADediting_563614 | chr16_698722_- | SINE | Alu | Name=AluSg |
| ADediting_563616 | chr16_698731_- | SINE | Alu | Name=AluSg |
| ADediting_563617 | chr16_698734_- | SINE | Alu | Name=AluSg |
| ADediting_563618 | chr16_698743_- | SINE | Alu | Name=AluSg |
| ADediting_563619 | chr16_698748_- | SINE | Alu | Name=AluSg |
| ADediting_563620 | chr16_698751_- | SINE | Alu | Name=AluSg |
| ADediting_563621 | chr16_698757_- | SINE | Alu | Name=AluSg |
| ADediting_563622 | chr16_698765_- | SINE | Alu | Name=AluSg |
| ADediting_563623 | chr16_698766_- | SINE | Alu | Name=AluSg |
| ADediting_563624 | chr16_698775_- | SINE | Alu | Name=AluSg |
| ADediting_563625 | chr16_698776_- | SINE | Alu | Name=AluSg |
| ADediting_563626 | chr16_698790_- | SINE | Alu | Name=AluSg |
| ADediting_563627 | chr16_698831_- | SINE | Alu | Name=AluSg |
| ADediting_563628 | chr16_698832_- | SINE | Alu | Name=AluSg |
| ADediting_563631 | chr16_698878_- | SINE | Alu | Name=AluSg |
| ADediting_1543903 | chr16_698682_- | SINE | Alu | Name=AluSg |
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RNA A-to-I editing events in the alternative splicing sites for FBXL16 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for FBXL16 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for FBXL16 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for FBXL16 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000127585.12 | ENST00000324361.9 | FBXL16-201 | hsa-miR-589-3p | chr16 | 693116 | 693122 | 7mer-m8 | 693115 | 693137 | 152 | -23.12 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000127585.12 | ENST00000324361.9 | FBXL16-201 | hsa-miR-589-3p | chr16 | 693126 | 693132 | 7mer-1a | 693115 | 693137 | 152 | -23.12 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000127585.12 | ENST00000397621.6 | FBXL16-202 | hsa-miR-589-3p | chr16 | 693116 | 693122 | 7mer-m8 | 693115 | 693137 | 152 | -23.12 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000127585.12 | ENST00000397621.6 | FBXL16-202 | hsa-miR-589-3p | chr16 | 693126 | 693132 | 7mer-1a | 693115 | 693137 | 152 | -23.12 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000127585.12 | ENST00000562563.1 | FBXL16-203 | hsa-miR-589-3p | chr16 | 693116 | 693122 | 7mer-m8 | 693115 | 693137 | 152 | -23.12 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000127585.12 | ENST00000562563.1 | FBXL16-203 | hsa-miR-589-3p | chr16 | 693126 | 693132 | 7mer-1a | 693115 | 693137 | 152 | -23.12 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000127585.12 | ENST00000324361.9 | FBXL16-201 | hsa-miR-381-3p | chr16 | 692597 | 692604 | 8mer-1a | 692597 | 692620 | 152 | -16.29 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000127585.12 | ENST00000397621.6 | FBXL16-202 | hsa-miR-381-3p | chr16 | 692597 | 692604 | 8mer-1a | 692597 | 692620 | 152 | -16.29 |
| ADediting_496066 | chr15_66496985_- | ENSG00000127585.12 | ENST00000324361.9 | FBXL16-201 | hsa-miR-4512 | chr16 | 693664 | 693671 | 8mer-1a | 693664 | 693684 | 142 | -18.75 |
| ADediting_496066 | chr15_66496985_- | ENSG00000127585.12 | ENST00000397621.6 | FBXL16-202 | hsa-miR-4512 | chr16 | 693664 | 693671 | 8mer-1a | 693664 | 693684 | 142 | -18.75 |
| ADediting_496066 | chr15_66496985_- | ENSG00000127585.12 | ENST00000562563.1 | FBXL16-203 | hsa-miR-4512 | chr16 | 693664 | 693671 | 8mer-1a | 693664 | 693684 | 142 | -18.75 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000127585.12 | ENST00000324361.9 | FBXL16-201 | hsa-miR-4775 | chr16 | 692635 | 692641 | 7mer-m8 | 692634 | 692655 | 150 | -8.41 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000127585.12 | ENST00000397621.6 | FBXL16-202 | hsa-miR-4775 | chr16 | 692635 | 692641 | 7mer-m8 | 692634 | 692655 | 150 | -8.41 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for FBXL16 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for FBXL16 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_563377 | chr16_697742_- | 0.00234516900012143 | 0.246643699447721 | 1.73538527426939e-07 | 0.411095340245475 | 0.160888545587496 | 0.115062076580498 |
| CER | ADediting_563379 | chr16_697744_- | 0.000253391125492829 | 0.29454906016071 | 1.12374387638702e-06 | 0.385288599938497 | 0.0508038414366319 | 0.159783180837169 |
| CER | ADediting_563385 | chr16_697807_- | 0.00375669112966762 | 0.235250569145851 | 1.57937530095727e-07 | 0.412340803154429 | 0.00790943270646537 | 0.216093613255009 |
| CER | ADediting_563386 | chr16_697811_- | 0.000236393292401303 | 0.295914393417658 | 1.13645860574505e-06 | 0.385126344525383 | 0.0101213939043613 | 0.209393288983954 |
| TCX | ADediting_563386 | chr16_697811_- | 0.0407495789675233 | 0.167281162988833 | 0.000108860787293853 | 0.310721048096257 | 0.313608528649206 | -0.0828280765860828 |
| CER | ADediting_563391 | chr16_697836_- | 0.000302206946968661 | 0.291054103793017 | 1.12254008590315e-06 | 0.385304052259078 | 0.0173357541706936 | 0.194058740300247 |
| CER | ADediting_563392 | chr16_697842_- | 0.014442644434699 | 0.199378513316816 | 4.0956247349716e-05 | 0.328341368146922 | 0.00531893632725315 | 0.226491868373389 |
| CER | ADediting_563393 | chr16_697856_- | 2.93592647854226e-06 | 0.371115080910781 | 1.36104988458189e-09 | 0.469452778599791 | 0.0138874277981539 | 0.200504504987339 |
| CER | ADediting_563394 | chr16_697876_- | 1.61306927777335e-05 | 0.344186148634183 | 4.79105291437722e-09 | 0.455327242120979 | 0.00520093366154371 | 0.227066571408457 |
| TCX | ADediting_563394 | chr16_697876_- | 0.00500217560019975 | 0.228061480629077 | 2.53872998492473e-06 | 0.373303714566671 | 0.776879919910744 | 0.0233305010808857 |
| CER | ADediting_563395 | chr16_697888_- | 1.27569472212547e-05 | 0.348044026645158 | 0.0010489657782781 | 0.264987256799451 | 0.0438603635399802 | 0.164810233743757 |
| CER | ADediting_563403 | chr16_698070_- | 2.06634342707263e-05 | 0.340058669025654 | 6.00078181515069e-11 | 0.501943125223442 | 0.00224018565767289 | 0.247723985677153 |
| TCX | ADediting_563403 | chr16_698070_- | 0.00291850369748544 | 0.241419826652619 | 4.02693446028023e-05 | 0.328636860671264 | 0.41458475511752 | 0.0671002460304986 |
| TCX | ADediting_563417 | chr16_698089_- | 0.000104130103661893 | 0.311546087803133 | 8.13025340401781e-05 | 0.316097801643495 | 0.937957233186519 | -0.00640896265992573 |
| CER | ADediting_563438 | chr16_698106_- | 0.000120362332997412 | 0.30884696408409 | 5.40436797471581e-08 | 0.426175415616923 | 0.000832652954254776 | 0.270021555371038 |
| CER | ADediting_563441 | chr16_698109_- | 0.00057399971935293 | 0.277934059021493 | 4.33045348975843e-07 | 0.398734681723744 | 0.0824537471044602 | 0.142262645181341 |
| CER | ADediting_563443 | chr16_698115_- | 2.92030772214007e-05 | 0.334193581262735 | 7.8919341553248e-10 | 0.475376164841713 | 0.120492900151418 | 0.127326655323039 |
| CER | ADediting_563445 | chr16_698132_- | 4.21484505244929e-07 | 0.399107708691455 | 4.17691632553529e-14 | 0.566465706139849 | 0.0122652199879326 | 0.204036069055197 |
| TCX | ADediting_563445 | chr16_698132_- | 0.00414853869787167 | 0.232783314272024 | 4.39104762499003e-06 | 0.364969219316929 | 0.185221249317376 | -0.108762121402088 |
| CER | ADediting_563446 | chr16_698136_- | 0.00437762942754684 | 0.231436244175512 | 5.28550933399701e-07 | 0.395973147248807 | 0.130944681316692 | 0.123883370979058 |
| CER | ADediting_563459 | chr16_698168_- | 1.57954708869144e-08 | 0.441316731290977 | 3.19937545292065e-16 | 0.603021782390876 | 0.00976347234193157 | 0.210383601085172 |
| TCX | ADediting_563459 | chr16_698168_- | 0.00317631614811234 | 0.239368341635015 | 6.17579938492941e-07 | 0.393798596048226 | 0.468146708889445 | -0.059683088152167 |
| CER | ADediting_563461 | chr16_698176_- | 6.95593619868338e-10 | 0.476732314277874 | 1.81790438886465e-14 | 0.573039629341251 | 0.00553424133949825 | 0.225472032547335 |
| TCX | ADediting_563461 | chr16_698176_- | 0.00147200889860462 | 0.257420994971476 | 7.50918607100192e-07 | 0.391045619122851 | 0.314062673486239 | -0.0827506476253989 |
| CER | ADediting_563467 | chr16_698230_- | 0.000400051398827983 | 0.285395958187778 | 3.43199747249574e-08 | 0.431851246506799 | 0.0753526581736513 | 0.14564169090295 |
| CER | ADediting_563486 | chr16_698270_- | 8.33632567204332e-06 | 0.354912375252363 | 1.46918704336719e-10 | 0.492966499648299 | 0.0116372837203122 | 0.205513953654891 |
| CER | ADediting_563488 | chr16_698276_- | 3.83848009988385e-09 | 0.457862393428514 | 5.26154381053576e-14 | 0.564615313928263 | 0.207418382577595 | 0.103524613509453 |
| CER | ADediting_563489 | chr16_698278_- | 2.24509108836556e-08 | 0.43706370996236 | 1.62372284205233e-12 | 0.535689719502455 | 0.0360093467435443 | 0.171369759508715 |
| CER | ADediting_563610 | chr16_698658_- | 1.1503568504376e-05 | 0.349728374532301 | 1.81314454262913e-11 | 0.513547960752887 | 0.0335182484480656 | 0.173703837658015 |
| TCX | ADediting_563610 | chr16_698658_- | 0.00535728169733236 | 0.2263075694887 | 1.58100885486651e-05 | 0.344518209263095 | 0.692689893997396 | -0.0325321446094627 |
| CER | ADediting_563611 | chr16_698660_- | 2.53867517124544e-05 | 0.336582455275789 | 1.34675722086308e-10 | 0.493850304574153 | 0.003481145820651 | 0.237128246319779 |
| CER | ADediting_563612 | chr16_698666_- | 1.19338320845093e-06 | 0.384420486474679 | 2.2817029490646e-13 | 0.552579968042456 | 0.00232561450241103 | 0.246841548414251 |
| TCX | ADediting_563612 | chr16_698666_- | 0.000860615844115249 | 0.269307391368849 | 5.39602481617475e-06 | 0.36177299259713 | 0.787637627471611 | -0.0221775675274123 |
| CER | ADediting_563613 | chr16_698672_- | 8.15397415056876e-07 | 0.38987801643501 | 3.97956920011103e-06 | 0.36648316736581 | 0.0740530588116082 | 0.146287693377005 |
| TCX | ADediting_563613 | chr16_698672_- | 0.000139362126082704 | 0.306089389312806 | 1.07366025307621e-05 | 0.350846790839378 | 0.445600306656725 | -0.0627434264513231 |
| CER | ADediting_563614 | chr16_698722_- | 1.25862816070796e-05 | 0.348263932229889 | 9.59497761711092e-14 | 0.559744886353899 | 0.000666846274983796 | 0.274773192557946 |
| CER | ADediting_563616 | chr16_698731_- | 0.000303007324187073 | 0.291001292739331 | 2.69996483889564e-05 | 0.335534187894141 | 0.595578432805652 | 0.0436818828151983 |
| CER | ADediting_563617 | chr16_698734_- | 0.000581834563346629 | 0.277649777021894 | 1.24322943343877e-05 | 0.348464777789311 | 0.219706524654045 | 0.100797131733391 |
| CER | ADediting_563618 | chr16_698743_- | 1.84696450597809e-07 | 0.41026867378053 | 2.53700667586456e-15 | 0.588040854972205 | 7.14117649714658e-05 | 0.318454749242139 |
| CER | ADediting_563619 | chr16_698748_- | 4.05100102276801e-05 | 0.328532795801784 | 8.45808139842244e-11 | 0.498532872449546 | 0.0143161427846738 | 0.199631693238664 |
| CER | ADediting_563620 | chr16_698751_- | 0.00105778135175487 | 0.264802995834155 | 9.43627327547289e-11 | 0.497437564048871 | 0.000875144817262786 | 0.268944693502802 |
| CER | ADediting_563621 | chr16_698757_- | 0.00267264806309599 | 0.243534786977422 | 1.20057518645758e-08 | 0.444595051147789 | 0.00502009777937968 | 0.227970331566905 |
| CER | ADediting_563624 | chr16_698775_- | 0.0144045277793801 | 0.199454595393062 | 3.33424747721891e-08 | 0.432208939784702 | 0.00644000142661303 | 0.221536191787699 |
| TCX | ADediting_563624 | chr16_698775_- | 0.0312889493299774 | 0.175920672146627 | 3.45499150300647e-05 | 0.331299347174811 | 0.557316551954781 | 0.048290637485558 |
| CER | ADediting_563625 | chr16_698776_- | 0.0005620593300329 | 0.27837426226551 | 4.66744904967738e-09 | 0.45562723951768 | 0.000293448780540003 | 0.291640619960346 |
| TCX | ADediting_563625 | chr16_698776_- | 0.402638376702293 | 0.0688288078353487 | 0.000114114824958657 | 0.309843092375341 | 0.59760845481829 | -0.0434412352081173 |
| CER | ADediting_563626 | chr16_698790_- | 0.000402321054056258 | 0.285280609950256 | 1.75735542572914e-09 | 0.466635891499245 | 0.0250831740405355 | 0.182889400275369 |
| DLPFC | ADediting_563627 | chr16_698831_- | 3.64953099438429e-07 | 0.284062092521974 | 6.49042681922255e-08 | 0.301034680434856 | 0.0397433326024907 | 0.116867658352466 |
| CER | ADediting_563627 | chr16_698831_- | 0.0015034964318981 | 0.256940935106877 | 1.69615736640069e-09 | 0.467028116415417 | 0.000605536947834858 | 0.276810734930254 |
| TCX | ADediting_563627 | chr16_698831_- | 0.00381273329131201 | 0.234883909813049 | 7.63505899543632e-05 | 0.317242094349989 | 0.561934711906266 | 0.0477266263443182 |
| CER | ADediting_563628 | chr16_698832_- | 0.0381989729671078 | 0.169428140802353 | 1.30324977301091e-06 | 0.383144427741349 | 0.00173386902896821 | 0.253683853162087 |
| CER | ADediting_563631 | chr16_698878_- | 0.000168408944627499 | 0.302486702960483 | 5.47490308733763e-09 | 0.453791313211367 | 0.00533422822852885 | 0.226418229166786 |
| TCX | ADediting_563631 | chr16_698878_- | 0.00259890842508084 | 0.244203473255158 | 2.81750343809109e-05 | 0.334806770252395 | 0.633199212337233 | 0.0392791121561735 |
| CER | ADediting_565093 | chr16_703917_- | 8.96215511143643e-05 | 0.314314687428483 | 0.000233070562431808 | 0.296191903689813 | 0.117727950330137 | 0.128276037468785 |
| TCX | ADediting_565597 | chr16_704606_- | 0.0129606460381264 | 0.202474855547632 | 1.30152542596655e-05 | 0.347716422194348 | 0.516498600777443 | -0.0533791478484465 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 2.21245594181703e-38 | 0.648518736705448 | 1.46080946081622e-54 | 0.73804398685985 | 2.78140652705422e-08 | 0.308979250561086 |
| AC | 1.36372200680834e-24 | 0.58748335675268 | 3.88935457532708e-48 | 0.759082532810564 | 0.0123244516651613 | 0.158081349253986 |
| PCC | 8.24540061485248e-35 | 0.74311254632489 | 5.78811553815934e-35 | 0.744233052125211 | 3.01148458744367e-05 | 0.297026114717975 |
| CER | 1.70606955884883e-10 | 0.491442202482568 | 1.80879887464916e-18 | 0.63733181463406 | 0.103124949910438 | 0.133600220874436 |
| TCX | 1.50201668742529e-10 | 0.492741620853951 | 2.47427832993185e-23 | 0.699264390586928 | 6.63875570562662e-07 | -0.392783523268812 |
| FP | 1.91928893022708e-05 | 0.314408796090897 | 0.932431005657231 | 0.00640005335081139 | 1.47943158518368e-05 | 0.318428346271263 |
| IFG | 5.38541248668156e-06 | 0.775040107355335 | 4.00215238476241e-07 | 0.824589999709084 | 0.152765204741493 | 0.294657268649031 |
| STG | 0.000608063695972379 | 0.366417002004852 | 0.0295413823941622 | 0.237590176549317 | 0.0083383173861593 | 0.286079524834266 |
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Relation with AD stages for FBXL16 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_563386 | chr16_697811_- | 0.000371577618298297 | 0.33638822769394 |
| CER | ADediting_563393 | chr16_697856_- | 1.58235290054059e-05 | 0.402377265637505 |
| CER | ADediting_563394 | chr16_697876_- | 0.000102428910404394 | 0.365072303526016 |
| CER | ADediting_563403 | chr16_698070_- | 0.00105987642080239 | 0.310828140312662 |
| CER | ADediting_563438 | chr16_698106_- | 0.000158795290769476 | 0.355615350222883 |
| CER | ADediting_563441 | chr16_698109_- | 0.00160010728244151 | 0.300134584272669 |
| CER | ADediting_563443 | chr16_698115_- | 0.000161017833427245 | 0.355310678725922 |
| CER | ADediting_563445 | chr16_698132_- | 0.00039979571324155 | 0.33467352001812 |
| CER | ADediting_563459 | chr16_698168_- | 0.000223768710365564 | 0.348005531066305 |
| CER | ADediting_563612 | chr16_698666_- | 7.45499373803051e-05 | 0.371745876267585 |
| CER | ADediting_563614 | chr16_698722_- | 7.7172934986545e-07 | 0.454607384976998 |
| CER | ADediting_563618 | chr16_698743_- | 4.84267510349746e-07 | 0.461944848347487 |
| CER | ADediting_563620 | chr16_698751_- | 0.00069422462043659 | 0.32141563545139 |
| CER | ADediting_563621 | chr16_698757_- | 0.000146957504680766 | 0.357307951735238 |
| CER | ADediting_563624 | chr16_698775_- | 0.000127343144902017 | 0.360413139421254 |
| CER | ADediting_563625 | chr16_698776_- | 0.000104862318169327 | 0.364573261535161 |
| CER | ADediting_563626 | chr16_698790_- | 8.18316302360306e-05 | 0.369803298211762 |
| CER | ADediting_563627 | chr16_698831_- | 9.9103086271422e-05 | 0.365772505588895 |
| CER | ADediting_563631 | chr16_698878_- | 0.000259251457912305 | 0.344680105003553 |
| TCX | ADediting_563377 | chr16_697742_- | 0.00096936256073173 | 0.315949728145888 |
| TCX | ADediting_563486 | chr16_698270_- | 0.000665031238064126 | 0.325400438324623 |
| TCX | ADediting_563487 | chr16_698275_- | 0.000972964461286339 | 0.315855171838503 |
| TCX | ADediting_563488 | chr16_698276_- | 0.000388555350396372 | 0.338375781747659 |
| TCX | ADediting_563610 | chr16_698658_- | 0.00118772580908408 | 0.31072450116828 |
| TCX | ADediting_563612 | chr16_698666_- | 0.000685416125314044 | 0.324654296348676 |
| TCX | ADediting_563613 | chr16_698672_- | 0.0012680423868603 | 0.309021302586335 |
| TCX | ADediting_565093 | chr16_703917_- | 0.00168793555152855 | 0.301455755165099 |
| IFG | ADediting_563445 | chr16_698132_- | 0.0113059937049014 | 0.497952103823781 |
| IFG | ADediting_563459 | chr16_698168_- | 0.0354713369979928 | 0.422303326441651 |
| IFG | ADediting_563486 | chr16_698270_- | 0.0030162104705458 | 0.568654731101904 |
| IFG | ADediting_563487 | chr16_698275_- | 0.0114683904084976 | 0.49710219232641 |
| IFG | ADediting_563488 | chr16_698276_- | 0.00951146646205648 | 0.508088772762205 |
| IFG | ADediting_563489 | chr16_698278_- | 0.00951146646205648 | 0.508088772762205 |
| IFG | ADediting_563610 | chr16_698658_- | 0.0113059937049014 | 0.497952103823781 |
| IFG | ADediting_563612 | chr16_698666_- | 0.0113059937049014 | 0.497952103823781 |
| IFG | ADediting_563613 | chr16_698672_- | 0.0353488225216572 | 0.42255826357712 |
| IFG | ADediting_563616 | chr16_698731_- | 0.0354713369979928 | 0.422303326441651 |
| IFG | ADediting_563626 | chr16_698790_- | 0.0354713369979928 | 0.422303326441651 |
| IFG | ADediting_565093 | chr16_703917_- | 0.0354713369979928 | 0.422303326441651 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for FBXL16 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FBXL16 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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