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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for UBXN2B |
 Gene summary |
| Gene information | Gene symbol | UBXN2B | Gene ID | 137886 |
| Gene name | UBX domain protein 2B | |
| Synonyms | p37 | |
| Cytomap | 8q12.1 | |
| Type of gene | protein-coding | |
| Description | UBX domain-containing protein 2BNSFL1 cofactor p37p97 cofactor p37 | |
| Modification date | 20200313 | |
| UniProtAcc | Q14CS0, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for UBXN2B |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1416637(58413316, +), ADediting_1416638(58413317, +), ADediting_1416639(58418055, +), ADediting_1416640(58418065, +), ADediting_1416641(58418085, +), ADediting_1416642(58418094, +), ADediting_1416643(58418118, +), ADediting_1416644(58418120, +), ADediting_1416645(58418121, +), ADediting_1416646(58418150, +), ADediting_1416647(58418173, +), ADediting_1416648(58418176, +), ADediting_1416649(58419643, +), ADediting_1416650(58419654, +), ADediting_1416651(58419669, +), ADediting_1416652(58419670, +), ADediting_1416653(58419679, +), ADediting_1416654(58419680, +), ADediting_1416655(58419687, +), ADediting_1416656(58419694, +), ADediting_1416657(58419698, +), ADediting_1416658(58419699, +), ADediting_1416659(58419702, +), ADediting_1416660(58419704, +), ADediting_1416661(58419707, +), ADediting_1416662(58419711, +), ADediting_1416663(58419712, +), ADediting_1416664(58419750, +), ADediting_1416665(58423575, +), ADediting_1416666(58423642, +), ADediting_1416667(58427205, +), ADediting_1416668(58427245, +), ADediting_1416669(58427268, +), ADediting_1416670(58427269, +), ADediting_1416671(58427284, +), ADediting_1416672(58427342, +), ADediting_1416673(58427349, +), ADediting_1416674(58427365, +), ADediting_1416675(58427366, +), ADediting_1416676(58427377, +), ADediting_1416677(58428454, +), ADediting_1416678(58428515, +), ADediting_1416679(58428518, +), ADediting_1416680(58428543, +), ADediting_1416681(58431228, +), ADediting_1416682(58431229, +), ADediting_1416683(58431259, +), ADediting_1416684(58431271, +), ADediting_1416685(58432644, +), ADediting_1416686(58432656, +), ADediting_1416687(58433593, +), ADediting_1416688(58433678, +), ADediting_1416689(58433681, +), ADediting_1416690(58433711, +), ADediting_1416691(58433754, +), ADediting_1416692(58441046, +), ADediting_1416693(58443531, +), ADediting_1416694(58443537, +), ADediting_1416695(58443543, +), ADediting_1416696(58448230, +), ADediting_1416697(58448267, +), ADediting_1416698(58448417, +), ADediting_1416699(58448426, +), ADediting_1416700(58448435, +), ADediting_1416701(58448436, +), ADediting_1416702(58448448, +), ADediting_1416703(58448454, +), ADediting_1591300(58431252, +), ADediting_1670424(58414397, +), ADediting_1670425(58419672, +), ADediting_1670426(58419719, +), ADediting_1670427(58419720, +), ADediting_1670428(58423553, +), ADediting_1670429(58427320, +), ADediting_1670430(58427348, +), ADediting_1670431(58427372, +), ADediting_1670432(58448434, +), |
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RNA editing positional annotations for UBXN2B using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1416637 | chr8_58413316_+ | intronic |
| ADediting_1416638 | chr8_58413317_+ | intronic |
| ADediting_1416639 | chr8_58418055_+ | intronic |
| ADediting_1416640 | chr8_58418065_+ | intronic |
| ADediting_1416641 | chr8_58418085_+ | intronic |
| ADediting_1416642 | chr8_58418094_+ | intronic |
| ADediting_1416643 | chr8_58418118_+ | intronic |
| ADediting_1416644 | chr8_58418120_+ | intronic |
| ADediting_1416645 | chr8_58418121_+ | intronic |
| ADediting_1416646 | chr8_58418150_+ | intronic |
| ADediting_1416647 | chr8_58418173_+ | intronic |
| ADediting_1416648 | chr8_58418176_+ | intronic |
| ADediting_1416649 | chr8_58419643_+ | intronic |
| ADediting_1416650 | chr8_58419654_+ | intronic |
| ADediting_1416651 | chr8_58419669_+ | intronic |
| ADediting_1416652 | chr8_58419670_+ | intronic |
| ADediting_1416653 | chr8_58419679_+ | intronic |
| ADediting_1416654 | chr8_58419680_+ | intronic |
| ADediting_1416655 | chr8_58419687_+ | intronic |
| ADediting_1416656 | chr8_58419694_+ | intronic |
| ADediting_1416657 | chr8_58419698_+ | intronic |
| ADediting_1416658 | chr8_58419699_+ | intronic |
| ADediting_1416659 | chr8_58419702_+ | intronic |
| ADediting_1416660 | chr8_58419704_+ | intronic |
| ADediting_1416661 | chr8_58419707_+ | intronic |
| ADediting_1416662 | chr8_58419711_+ | intronic |
| ADediting_1416663 | chr8_58419712_+ | intronic |
| ADediting_1416664 | chr8_58419750_+ | intronic |
| ADediting_1416665 | chr8_58423575_+ | intronic |
| ADediting_1416666 | chr8_58423642_+ | intronic |
| ADediting_1416667 | chr8_58427205_+ | intronic |
| ADediting_1416668 | chr8_58427245_+ | intronic |
| ADediting_1416669 | chr8_58427268_+ | intronic |
| ADediting_1416670 | chr8_58427269_+ | intronic |
| ADediting_1416671 | chr8_58427284_+ | intronic |
| ADediting_1416672 | chr8_58427342_+ | intronic |
| ADediting_1416673 | chr8_58427349_+ | intronic |
| ADediting_1416674 | chr8_58427365_+ | intronic |
| ADediting_1416675 | chr8_58427366_+ | intronic |
| ADediting_1416676 | chr8_58427377_+ | intronic |
| ADediting_1416677 | chr8_58428454_+ | intronic |
| ADediting_1416678 | chr8_58428515_+ | intronic |
| ADediting_1416679 | chr8_58428518_+ | intronic |
| ADediting_1416680 | chr8_58428543_+ | intronic |
| ADediting_1416681 | chr8_58431228_+ | intronic |
| ADediting_1416682 | chr8_58431229_+ | intronic |
| ADediting_1416683 | chr8_58431259_+ | intronic |
| ADediting_1416684 | chr8_58431271_+ | intronic |
| ADediting_1416685 | chr8_58432644_+ | intronic |
| ADediting_1416686 | chr8_58432656_+ | intronic |
| ADediting_1416687 | chr8_58433593_+ | intronic |
| ADediting_1416688 | chr8_58433678_+ | intronic |
| ADediting_1416689 | chr8_58433681_+ | intronic |
| ADediting_1416690 | chr8_58433711_+ | intronic |
| ADediting_1416691 | chr8_58433754_+ | intronic |
| ADediting_1416692 | chr8_58441046_+ | intronic |
| ADediting_1416693 | chr8_58443531_+ | intronic |
| ADediting_1416694 | chr8_58443537_+ | intronic |
| ADediting_1416695 | chr8_58443543_+ | intronic |
| ADediting_1416696 | chr8_58448230_+ | UTR3 |
| ADediting_1416697 | chr8_58448267_+ | UTR3 |
| ADediting_1416698 | chr8_58448417_+ | UTR3 |
| ADediting_1416699 | chr8_58448426_+ | UTR3 |
| ADediting_1416700 | chr8_58448435_+ | UTR3 |
| ADediting_1416701 | chr8_58448436_+ | UTR3 |
| ADediting_1416702 | chr8_58448448_+ | UTR3 |
| ADediting_1416703 | chr8_58448454_+ | UTR3 |
| ADediting_1591300 | chr8_58431252_+ | intronic |
| ADediting_1670424 | chr8_58414397_+ | intronic |
| ADediting_1670425 | chr8_58419672_+ | intronic |
| ADediting_1670426 | chr8_58419719_+ | intronic |
| ADediting_1670427 | chr8_58419720_+ | intronic |
| ADediting_1670428 | chr8_58423553_+ | intronic |
| ADediting_1670429 | chr8_58427320_+ | intronic |
| ADediting_1670430 | chr8_58427348_+ | intronic |
| ADediting_1670431 | chr8_58427372_+ | intronic |
| ADediting_1670432 | chr8_58448434_+ | UTR3 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1416639 | chr8_58418055_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1416640 | chr8_58418065_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1416641 | chr8_58418085_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1416642 | chr8_58418094_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1416643 | chr8_58418118_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1416644 | chr8_58418120_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1416645 | chr8_58418121_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1416646 | chr8_58418150_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1416647 | chr8_58418173_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1416648 | chr8_58418176_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1416649 | chr8_58419643_+ | SINE | MIR | Name=MIRb |
| ADediting_1416650 | chr8_58419654_+ | SINE | MIR | Name=MIRb |
| ADediting_1416665 | chr8_58423575_+ | SINE | Alu | Name=AluY |
| ADediting_1416666 | chr8_58423642_+ | SINE | Alu | Name=AluY |
| ADediting_1416667 | chr8_58427205_+ | SINE | Alu | Name=AluJb |
| ADediting_1416668 | chr8_58427245_+ | SINE | Alu | Name=AluJb |
| ADediting_1416669 | chr8_58427268_+ | SINE | Alu | Name=AluJb |
| ADediting_1416670 | chr8_58427269_+ | SINE | Alu | Name=AluJb |
| ADediting_1416671 | chr8_58427284_+ | SINE | Alu | Name=AluJb |
| ADediting_1416672 | chr8_58427342_+ | SINE | Alu | Name=AluJb |
| ADediting_1416673 | chr8_58427349_+ | SINE | Alu | Name=AluJb |
| ADediting_1416674 | chr8_58427365_+ | SINE | Alu | Name=AluJb |
| ADediting_1416675 | chr8_58427366_+ | SINE | Alu | Name=AluJb |
| ADediting_1416676 | chr8_58427377_+ | SINE | Alu | Name=AluJb |
| ADediting_1416680 | chr8_58428543_+ | Simple_repeat | Simple_repeat | Name=(TGTCCTA)n |
| ADediting_1416681 | chr8_58431228_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1416682 | chr8_58431229_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1416683 | chr8_58431259_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1416684 | chr8_58431271_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1416685 | chr8_58432644_+ | SINE | Alu | Name=AluY |
| ADediting_1416686 | chr8_58432656_+ | SINE | Alu | Name=AluY |
| ADediting_1416687 | chr8_58433593_+ | SINE | Alu | Name=FLAM_A |
| ADediting_1416688 | chr8_58433678_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1416689 | chr8_58433681_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1416690 | chr8_58433711_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1416691 | chr8_58433754_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1416692 | chr8_58441046_+ | SINE | Alu | Name=AluJr |
| ADediting_1416693 | chr8_58443531_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1416694 | chr8_58443537_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1416695 | chr8_58443543_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1416696 | chr8_58448230_+ | SINE | Alu | Name=AluSp |
| ADediting_1416697 | chr8_58448267_+ | SINE | Alu | Name=AluSp |
| ADediting_1416698 | chr8_58448417_+ | SINE | Alu | Name=AluSp |
| ADediting_1416699 | chr8_58448426_+ | SINE | Alu | Name=AluSp |
| ADediting_1416700 | chr8_58448435_+ | SINE | Alu | Name=AluSp |
| ADediting_1416701 | chr8_58448436_+ | SINE | Alu | Name=AluSp |
| ADediting_1416702 | chr8_58448448_+ | SINE | Alu | Name=AluSp |
| ADediting_1416703 | chr8_58448454_+ | SINE | Alu | Name=AluSp |
| ADediting_1591300 | chr8_58431252_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1670428 | chr8_58423553_+ | SINE | Alu | Name=AluY |
| ADediting_1670429 | chr8_58427320_+ | SINE | Alu | Name=AluJb |
| ADediting_1670430 | chr8_58427348_+ | SINE | Alu | Name=AluJb |
| ADediting_1670431 | chr8_58427372_+ | SINE | Alu | Name=AluJb |
| ADediting_1670432 | chr8_58448434_+ | SINE | Alu | Name=AluSp |
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RNA A-to-I editing events in the alternative splicing sites for UBXN2B |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for UBXN2B |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for UBXN2B |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for UBXN2B |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1416696 | chr8_58448230_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-324-3p | chr8 | 58448226 | 58448232 | 7mer-m8 | 58448211 | 58448233 | 148 | -24.15 |
| ADediting_1416696 | chr8_58448230_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-4252 | chr8 | 58448227 | 58448234 | 8mer-1a | 58448214 | 58448234 | 149 | -22.82 |
| ADediting_1416696 | chr8_58448230_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-4793-3p | chr8 | 58448223 | 58448229 | 7mer-m8 | 58448208 | 58448230 | 149 | -19.36 |
| ADediting_1416697 | chr8_58448267_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-1247-3p | chr8 | 58448262 | 58448268 | 7mer-m8 | 58448247 | 58448269 | 150 | -23.34 |
| ADediting_1416698 | chr8_58448417_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-1228-5p | chr8 | 58448414 | 58448420 | 7mer-m8 | 58448402 | 58448421 | 145 | -24.49 |
| ADediting_1416700 | chr8_58448435_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-326 | chr8 | 58448430 | 58448436 | 7mer-m8 | 58448418 | 58448437 | 140 | -13.25 |
| ADediting_1416700 | chr8_58448435_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-330-5p | chr8 | 58448430 | 58448436 | 7mer-m8 | 58448414 | 58448437 | 141 | -19.11 |
| ADediting_1416700 | chr8_58448435_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-4314 | chr8 | 58448429 | 58448435 | 7mer-m8 | 58448418 | 58448436 | 141 | -20.85 |
| ADediting_1416700 | chr8_58448435_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-514a-5p | chr8 | 58448431 | 58448437 | 7mer-m8 | 58448415 | 58448438 | 150 | -18.62 |
| ADediting_1416701 | chr8_58448436_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-3189-3p | chr8 | 58448430 | 58448436 | 7mer-m8 | 58448414 | 58448437 | 157 | -25.36 |
| ADediting_1416701 | chr8_58448436_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-6813-3p | chr8 | 58448431 | 58448437 | 7mer-m8 | 58448418 | 58448438 | 140 | -10.68 |
| ADediting_1670432 | chr8_58448434_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-6771-5p | chr8 | 58448428 | 58448435 | 8mer-1a | 58448416 | 58448435 | 148 | -23.97 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1416696 | chr8_58448230_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-32-5p | chr8 | 58448224 | 58448230 | 7mer-m8 | 58448210 | 58448231 | 144 | -12.53 |
| ADediting_1416696 | chr8_58448230_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-363-3p | chr8 | 58448224 | 58448230 | 7mer-m8 | 58448210 | 58448231 | 147 | -16.12 |
| ADediting_1416696 | chr8_58448230_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-92a-3p | chr8 | 58448224 | 58448230 | 7mer-m8 | 58448214 | 58448231 | 155 | -26.92 |
| ADediting_1416697 | chr8_58448267_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-3689a-3p | chr8 | 58448260 | 58448266 | 7mer-m8 | 58448247 | 58448267 | 154 | -29.66 |
| ADediting_1416697 | chr8_58448267_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-490-3p | chr8 | 58448264 | 58448270 | 7mer-m8 | 58448249 | 58448271 | 146 | -17.12 |
| ADediting_1416697 | chr8_58448267_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-6779-5p | chr8 | 58448260 | 58448266 | 7mer-m8 | 58448249 | 58448267 | 152 | -25.71 |
| ADediting_1416697 | chr8_58448267_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-6780a-5p | chr8 | 58448260 | 58448266 | 7mer-m8 | 58448243 | 58448267 | 147 | -22.76 |
| ADediting_1416698 | chr8_58448417_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-3165 | chr8 | 58448412 | 58448418 | 7mer-m8 | 58448400 | 58448419 | 145 | -14.28 |
| ADediting_1416698 | chr8_58448417_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-6745 | chr8 | 58448413 | 58448420 | 8mer-1a | 58448396 | 58448420 | 146 | -24.25 |
| ADediting_1416698 | chr8_58448417_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-6748-5p | chr8 | 58448415 | 58448421 | 7mer-m8 | 58448402 | 58448422 | 149 | -22.28 |
| ADediting_1416698 | chr8_58448417_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-6756-5p | chr8 | 58448414 | 58448420 | 7mer-1a | 58448396 | 58448420 | 144 | -28.15 |
| ADediting_1416699 | chr8_58448426_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-4478 | chr8 | 58448423 | 58448429 | 7mer-m8 | 58448414 | 58448430 | 154 | -23.41 |
| ADediting_1416699 | chr8_58448426_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-485-5p | chr8 | 58448424 | 58448430 | 7mer-m8 | 58448410 | 58448431 | 149 | -16.76 |
| ADediting_1416699 | chr8_58448426_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-7160-5p | chr8 | 58448421 | 58448427 | 7mer-m8 | 58448411 | 58448428 | 148 | -19.34 |
| ADediting_1416699 | chr8_58448426_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-7162-3p | chr8 | 58448420 | 58448426 | 7mer-m8 | 58448409 | 58448427 | 150 | -18.37 |
| ADediting_1416700 | chr8_58448435_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-887-5p | chr8 | 58448428 | 58448435 | 8mer-1a | 58448416 | 58448435 | 143 | -13.53 |
| ADediting_1416703 | chr8_58448454_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-6514-3p | chr8 | 58448447 | 58448453 | 7mer-m8 | 58448434 | 58448454 | 155 | -17.54 |
| ADediting_1416703 | chr8_58448454_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-6847-3p | chr8 | 58448452 | 58448458 | 7mer-m8 | 58448437 | 58448459 | 153 | -22.19 |
| ADediting_1670432 | chr8_58448434_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-1273h-5p | chr8 | 58448427 | 58448434 | 8mer-1a | 58448415 | 58448434 | 151 | -19.49 |
| ADediting_1670432 | chr8_58448434_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-30b-3p | chr8 | 58448427 | 58448434 | 8mer-1a | 58448413 | 58448434 | 155 | -16.01 |
| ADediting_1670432 | chr8_58448434_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-3689a-3p | chr8 | 58448427 | 58448434 | 8mer-1a | 58448413 | 58448434 | 149 | -22.05 |
| ADediting_1670432 | chr8_58448434_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-3689b-3p | chr8 | 58448427 | 58448434 | 8mer-1a | 58448413 | 58448434 | 149 | -22.1 |
| ADediting_1670432 | chr8_58448434_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-3689c | chr8 | 58448427 | 58448434 | 8mer-1a | 58448413 | 58448434 | 149 | -22.1 |
| ADediting_1670432 | chr8_58448434_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-6779-5p | chr8 | 58448427 | 58448434 | 8mer-1a | 58448416 | 58448434 | 152 | -22.88 |
| ADediting_1670432 | chr8_58448434_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-6780a-5p | chr8 | 58448427 | 58448434 | 8mer-1a | 58448411 | 58448434 | 148 | -20.23 |
| ADediting_1670432 | chr8_58448434_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-887-5p | chr8 | 58448428 | 58448435 | 8mer-1a | 58448416 | 58448435 | 143 | -13.53 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1416638 | chr8_58413317_+ | ENSG00000215114.9 | ENST00000522978.1 | UBXN2B-204 | hsa-miR-4326 | chr8 | 58413315 | 58413321 | 7mer-m8 | 58413303 | 58413322 | 140 | -12.01 |
| ADediting_1416638 | chr8_58413317_+ | ENSG00000215114.9 | ENST00000522978.1 | UBXN2B-204 | hsa-miR-670-3p | chr8 | 58413314 | 58413320 | 7mer-m8 | 58413301 | 58413321 | 171 | -19.93 |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1416637 | chr8_58413316_+ | ENSG00000215114.9 | ENST00000522978.1 | UBXN2B-204 | hsa-miR-22-5p | chr8 | 58413315 | 58413321 | 7mer-m8 | 58413301 | 58413322 | 145 | -12.65 |
| ADediting_1416637 | chr8_58413316_+ | ENSG00000215114.9 | ENST00000522978.1 | UBXN2B-204 | hsa-miR-23a-3p | chr8 | 58413310 | 58413317 | 8mer-1a | 58411468 | 58413317 | 143 | -8.05 |
| ADediting_1416637 | chr8_58413316_+ | ENSG00000215114.9 | ENST00000522978.1 | UBXN2B-204 | hsa-miR-23b-3p | chr8 | 58413310 | 58413317 | 8mer-1a | 58413299 | 58413317 | 141 | -8.44 |
| ADediting_1416637 | chr8_58413316_+ | ENSG00000215114.9 | ENST00000522978.1 | UBXN2B-204 | hsa-miR-23c | chr8 | 58413310 | 58413317 | 8mer-1a | 58411467 | 58413317 | 148 | -7.38 |
| ADediting_1416638 | chr8_58413317_+ | ENSG00000215114.9 | ENST00000522978.1 | UBXN2B-204 | hsa-miR-22-5p | chr8 | 58413315 | 58413321 | 7mer-m8 | 58413301 | 58413322 | 145 | -12.65 |
| ADediting_1416638 | chr8_58413317_+ | ENSG00000215114.9 | ENST00000522978.1 | UBXN2B-204 | hsa-miR-5584-3p | chr8 | 58413316 | 58413322 | 7mer-m8 | 58413302 | 58413323 | 154 | -9.9 |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-337-3p | chr8 | 58448676 | 58448683 | 8mer-1a | 58448659 | 58448683 | 146 | -17.13 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-337-3p | chr8 | 58448961 | 58448967 | 7mer-m8 | 58448949 | 58448968 | 154 | -24.04 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-337-3p | chr8 | 58448995 | 58449001 | 7mer-m8 | 58448981 | 58449002 | 145 | -9.6 |
| ADediting_291761 | chr11_93733708_- | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-1304-3p | chr8 | 58449672 | 58449678 | 7mer-m8 | 58449658 | 58449679 | 140 | -14.08 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-4775 | chr8 | 58448522 | 58448529 | 8mer-1a | 58448502 | 58448529 | 145 | -8.12 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-4775 | chr8 | 58451035 | 58451041 | 7mer-m8 | 58451021 | 58451042 | 140 | -7.29 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-5688 | chr8 | 58449816 | 58449822 | 7mer-m8 | 58449802 | 58449823 | 140 | -8.62 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-151a-3p | chr8 | 58450472 | 58450478 | 7mer-m8 | 58450459 | 58450479 | 141 | -11 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-4477b | chr8 | 58448786 | 58448792 | 7mer-m8 | 58448770 | 58448793 | 147 | -10.54 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-4477b | chr8 | 58448786 | 58448792 | 7mer-m8 | 58448770 | 58448793 | 147 | -10.54 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-641 | chr8 | 58448644 | 58448650 | 7mer-m8 | 58448625 | 58448651 | 153 | -17.1 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-641 | chr8 | 58448644 | 58448650 | 7mer-m8 | 58448625 | 58448651 | 153 | -17.1 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-4775 | chr8 | 58451143 | 58451149 | 7mer-m8 | 58451127 | 58451150 | 143 | -3.92 |
| ADediting_98288 | chr1_32086990_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-5585-3p | chr8 | 58450476 | 58450482 | 7mer-m8 | 58450461 | 58450483 | 147 | -11.61 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000215114.9 | ENST00000399598.7 | UBXN2B-201 | hsa-miR-5585-3p | chr8 | 58450476 | 58450482 | 7mer-m8 | 58450461 | 58450483 | 147 | -11.61 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for UBXN2B |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000522978.1 | lncRNA |  |  |
| ENST00000399598.7 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1416696 | ENST00000399598.7 | chr8_58448230_+ | 1700 | -1282.37 | -1278.57 | -1299.27 |
| ADediting_1416697 | ENST00000399598.7 | chr8_58448267_+ | 1737 | -1282.67 | -1278.57 | -1299.27 |
| ADediting_1416698 | ENST00000399598.7 | chr8_58448417_+ | 1887 | -1278.57 | -1278.57 | -1299.27 |
| ADediting_1416699 | ENST00000399598.7 | chr8_58448426_+ | 1896 | -1279.07 | -1278.57 | -1299.27 |
| ADediting_1670432 | ENST00000399598.7 | chr8_58448434_+ | 1904 | -1278.27 | -1278.57 | -1299.27 |
| ADediting_1416700 | ENST00000399598.7 | chr8_58448435_+ | 1905 | -1281.27 | -1278.57 | -1299.27 |
| ADediting_1416701 | ENST00000399598.7 | chr8_58448436_+ | 1906 | -1279.97 | -1278.57 | -1299.27 |
| ADediting_1416702 | ENST00000399598.7 | chr8_58448448_+ | 1918 | -1280.07 | -1278.57 | -1299.27 |
| ADediting_1416703 | ENST00000399598.7 | chr8_58448454_+ | 1924 | -1282.17 | -1278.57 | -1299.27 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1416637 | ENST00000522978.1 | chr8_58413316_+ | 129 | -210.10 | -209.40 | -210.00 |
| ADediting_1416638 | ENST00000522978.1 | chr8_58413317_+ | 130 | -209.50 | -209.40 | -210.00 |
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Relation with ADAR for UBXN2B |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| STG | ADediting_1416656 | chr8_58419694_+ | 0.000715774952413602 | 0.36198640460724 | 0.0146729065302488 | 0.265446381538056 | 0.974155190602591 | 0.00358859913713885 |
| DLPFC | ADediting_1416666 | chr8_58423642_+ | 0.448742033443043 | 0.043178259695502 | 0.0799398321753737 | -0.0996070452308973 | 1.60450132926144e-13 | 0.402795742824358 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 3.33409935128932e-92 | 0.860469569761217 | 4.92836131498288e-66 | 0.785060833735994 | 0.0500089477561144 | 0.111417414456101 |
| AC | 1.40793891543593e-116 | 0.938558083237058 | 1.67718443929399e-66 | 0.835724643864139 | 1.0131204748513e-11 | 0.413061188286021 |
| PCC | 8.17477916529185e-68 | 0.894007004628838 | 7.83231999625753e-63 | 0.879420474423385 | 0.021710907256412 | 0.166023906183466 |
| CER | 3.71205276062369e-50 | 0.881770213758047 | 1.07035880461061e-22 | 0.69197351181512 | 0.140623308596246 | 0.120878232516336 |
| TCX | 6.31876571511055e-66 | 0.929353473932023 | 8.15840702083129e-20 | 0.655994681878404 | 0.0672772624941464 | 0.149812884004246 |
| FP | 7.69601260342833e-36 | 0.767628254220913 | 2.69171173229533e-30 | 0.724870011506829 | 0.198687603078633 | 0.0967928434725516 |
| IFG | 5.14268916304549e-06 | 0.776044992310613 | 0.000114465842445429 | 0.695254289583587 | 0.970720040054488 | -0.00773707120202784 |
| PG | 2.0030536944659e-65 | 0.892194524162706 | 2.21774578353988e-33 | 0.738930765447033 | 0.729123684463505 | -0.0255594769593409 |
| STG | 1.81405951875194e-26 | 0.866519857668668 | 3.09627513476754e-20 | 0.804404762504887 | 0.971913890387193 | 0.00389992899020287 |
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Relation with AD stages for UBXN2B |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 7.10212684829565e-05 | 0.376070480336733 |
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RelatedDrugs for UBXN2B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBXN2B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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