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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

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The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

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Relation with ADAR

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Relation with AD stages

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Related drugs with this gene

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Related diseases with this gene


Gene summary for SDHAF4

check button Gene summary
Gene informationGene symbol

SDHAF4

Gene ID

135154

Gene namesuccinate dehydrogenase complex assembly factor 4
SynonymsC6orf57|Sdh8
Cytomap

6q13

Type of geneprotein-coding
Descriptionsuccinate dehydrogenase assembly factor 4, mitochondrialSDH assembly factor 4UPF0369 protein C6orf57
Modification date20200313
UniProtAcc

Q5VUM1,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for SDHAF4

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1273206(70573775, +), ADediting_1273207(70573814, +), ADediting_1273208(70573850, +), ADediting_1273209(70573878, +), ADediting_1273210(70573911, +), ADediting_1273211(70573914, +), ADediting_1273212(70573938, +), ADediting_1273213(70574106, +), ADediting_1273214(70574226, +), ADediting_1273215(70574275, +), ADediting_1273216(70574277, +), ADediting_1273217(70575146, +), ADediting_1273218(70575267, +), ADediting_1273219(70575307, +), ADediting_1273220(70584081, +), ADediting_1273221(70588400, +), ADediting_1273222(70588905, +), ADediting_1273223(70588914, +), ADediting_1273224(70588915, +), ADediting_1273225(70588924, +), ADediting_1273226(70588936, +), ADediting_1273227(70588939, +), ADediting_1273228(70588940, +), ADediting_1273229(70588941, +), ADediting_1273230(70588942, +), ADediting_1273231(70588943, +), ADediting_1273232(70588945, +), ADediting_1273233(70588948, +), ADediting_1273234(70588949, +), ADediting_1273235(70588953, +), ADediting_1273236(70588957, +), ADediting_1273237(70588973, +), ADediting_1273238(70588979, +), ADediting_1273239(70588980, +), ADediting_1273240(70588985, +), ADediting_1273241(70588986, +), ADediting_1273242(70588989, +), ADediting_1273243(70589002, +), ADediting_1273244(70589006, +), ADediting_1273245(70589009, +), ADediting_1273246(70589012, +), ADediting_1273247(70589019, +), ADediting_1273248(70589020, +), ADediting_1273249(70589025, +), ADediting_1273250(70589045, +), ADediting_1273251(70589050, +), ADediting_1273252(70589085, +), ADediting_1273253(70589090, +), ADediting_1273254(70589101, +), ADediting_1273255(70589102, +), ADediting_1273256(70589103, +), ADediting_1273257(70589104, +), ADediting_1273258(70589105, +), ADediting_1273259(70589109, +), ADediting_1273260(70589186, +), ADediting_1273261(70589188, +), ADediting_1273262(70589208, +), ADediting_1273263(70589220, +), ADediting_1273264(70589226, +), ADediting_1273265(70589229, +), ADediting_1273266(70589234, +), ADediting_1273267(70589235, +), ADediting_1273268(70589239, +), ADediting_1273269(70589245, +), ADediting_1273270(70589259, +), ADediting_1273271(70589265, +), ADediting_1273272(70589266, +), ADediting_1273273(70589269, +), ADediting_1273274(70589270, +), ADediting_1273275(70589283, +), ADediting_1273276(70589295, +), ADediting_1273277(70589305, +), ADediting_1273278(70589307, +), ADediting_1273279(70589331, +), ADediting_1273280(70589332, +), ADediting_1273281(70589340, +), ADediting_1273282(70589346, +), ADediting_1273283(70589349, +), ADediting_1273284(70589350, +), ADediting_1273285(70589351, +), ADediting_1273286(70589353, +), ADediting_1273287(70589355, +), ADediting_1273288(70589356, +), ADediting_1273289(70589363, +), ADediting_1273290(70589371, +), ADediting_1273291(70589375, +), ADediting_1273292(70589400, +), ADediting_1273293(70589418, +), ADediting_1273294(70589427, +), ADediting_1273295(70589428, +), ADediting_1273296(70589449, +), ADediting_1584297(70589070, +), ADediting_1662261(70588996, +), ADediting_1662262(70589065, +), ADediting_1662263(70589079, +),

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RNA editing positional annotations for SDHAF4 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1273206chr6_70573775_+intronic
ADediting_1273207chr6_70573814_+intronic
ADediting_1273208chr6_70573850_+intronic
ADediting_1273209chr6_70573878_+intronic
ADediting_1273210chr6_70573911_+intronic
ADediting_1273211chr6_70573914_+intronic
ADediting_1273212chr6_70573938_+intronic
ADediting_1273213chr6_70574106_+intronic
ADediting_1273214chr6_70574226_+intronic
ADediting_1273215chr6_70574275_+intronic
ADediting_1273216chr6_70574277_+intronic
ADediting_1273217chr6_70575146_+intronic
ADediting_1273218chr6_70575267_+intronic
ADediting_1273219chr6_70575307_+intronic
ADediting_1273220chr6_70584081_+intronic
ADediting_1273221chr6_70588400_+intronic
ADediting_1273222chr6_70588905_+UTR3
ADediting_1273223chr6_70588914_+UTR3
ADediting_1273224chr6_70588915_+UTR3
ADediting_1273225chr6_70588924_+UTR3
ADediting_1273226chr6_70588936_+UTR3
ADediting_1273227chr6_70588939_+UTR3
ADediting_1273228chr6_70588940_+UTR3
ADediting_1273229chr6_70588941_+UTR3
ADediting_1273230chr6_70588942_+UTR3
ADediting_1273231chr6_70588943_+UTR3
ADediting_1273232chr6_70588945_+UTR3
ADediting_1273233chr6_70588948_+UTR3
ADediting_1273234chr6_70588949_+UTR3
ADediting_1273235chr6_70588953_+UTR3
ADediting_1273236chr6_70588957_+UTR3
ADediting_1273237chr6_70588973_+UTR3
ADediting_1273238chr6_70588979_+UTR3
ADediting_1273239chr6_70588980_+UTR3
ADediting_1273240chr6_70588985_+UTR3
ADediting_1273241chr6_70588986_+UTR3
ADediting_1273242chr6_70588989_+UTR3
ADediting_1273243chr6_70589002_+UTR3
ADediting_1273244chr6_70589006_+UTR3
ADediting_1273245chr6_70589009_+UTR3
ADediting_1273246chr6_70589012_+UTR3
ADediting_1273247chr6_70589019_+UTR3
ADediting_1273248chr6_70589020_+UTR3
ADediting_1273249chr6_70589025_+UTR3
ADediting_1273250chr6_70589045_+UTR3
ADediting_1273251chr6_70589050_+UTR3
ADediting_1273252chr6_70589085_+UTR3
ADediting_1273253chr6_70589090_+UTR3
ADediting_1273254chr6_70589101_+UTR3
ADediting_1273255chr6_70589102_+UTR3
ADediting_1273256chr6_70589103_+UTR3
ADediting_1273257chr6_70589104_+UTR3
ADediting_1273258chr6_70589105_+UTR3
ADediting_1273259chr6_70589109_+UTR3
ADediting_1273260chr6_70589186_+UTR3
ADediting_1273261chr6_70589188_+UTR3
ADediting_1273262chr6_70589208_+UTR3
ADediting_1273263chr6_70589220_+UTR3
ADediting_1273264chr6_70589226_+UTR3
ADediting_1273265chr6_70589229_+UTR3
ADediting_1273266chr6_70589234_+UTR3
ADediting_1273267chr6_70589235_+UTR3
ADediting_1273268chr6_70589239_+UTR3
ADediting_1273269chr6_70589245_+UTR3
ADediting_1273270chr6_70589259_+UTR3
ADediting_1273271chr6_70589265_+UTR3
ADediting_1273272chr6_70589266_+UTR3
ADediting_1273273chr6_70589269_+UTR3
ADediting_1273274chr6_70589270_+UTR3
ADediting_1273275chr6_70589283_+UTR3
ADediting_1273276chr6_70589295_+UTR3
ADediting_1273277chr6_70589305_+UTR3
ADediting_1273278chr6_70589307_+UTR3
ADediting_1273279chr6_70589331_+UTR3
ADediting_1273280chr6_70589332_+UTR3
ADediting_1273281chr6_70589340_+UTR3
ADediting_1273282chr6_70589346_+UTR3
ADediting_1273283chr6_70589349_+UTR3
ADediting_1273284chr6_70589350_+UTR3
ADediting_1273285chr6_70589351_+UTR3
ADediting_1273286chr6_70589353_+UTR3
ADediting_1273287chr6_70589355_+UTR3
ADediting_1273288chr6_70589356_+UTR3
ADediting_1273289chr6_70589363_+UTR3
ADediting_1273290chr6_70589371_+UTR3
ADediting_1273291chr6_70589375_+UTR3
ADediting_1273292chr6_70589400_+UTR3
ADediting_1273293chr6_70589418_+UTR3
ADediting_1273294chr6_70589427_+UTR3
ADediting_1273295chr6_70589428_+UTR3
ADediting_1273296chr6_70589449_+UTR3
ADediting_1584297chr6_70589070_+UTR3
ADediting_1662261chr6_70588996_+UTR3
ADediting_1662262chr6_70589065_+UTR3
ADediting_1662263chr6_70589079_+UTR3

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1273206chr6_70573775_+SINEAluName=AluSx1
ADediting_1273207chr6_70573814_+SINEAluName=AluSx1
ADediting_1273208chr6_70573850_+SINEAluName=AluSx1
ADediting_1273209chr6_70573878_+SINEAluName=AluSx1
ADediting_1273210chr6_70573911_+SINEAluName=AluSx1
ADediting_1273211chr6_70573914_+SINEAluName=AluSx1
ADediting_1273212chr6_70573938_+SINEAluName=AluSx1
ADediting_1273213chr6_70574106_+SINEAluName=AluSx
ADediting_1273214chr6_70574226_+SINEAluName=AluSx
ADediting_1273215chr6_70574275_+SINEAluName=AluSx
ADediting_1273216chr6_70574277_+SINEAluName=AluSx
ADediting_1273217chr6_70575146_+SINEAluName=AluSz6
ADediting_1273218chr6_70575267_+SINEAluName=AluSz6
ADediting_1273219chr6_70575307_+SINEAluName=AluSz6
ADediting_1273220chr6_70584081_+SINEAluName=AluSg
ADediting_1273221chr6_70588400_+SINEAluName=AluSz
ADediting_1273222chr6_70588905_+SINEAluName=AluSp
ADediting_1273223chr6_70588914_+SINEAluName=AluSp
ADediting_1273224chr6_70588915_+SINEAluName=AluSp
ADediting_1273225chr6_70588924_+SINEAluName=AluSp
ADediting_1273226chr6_70588936_+SINEAluName=AluSp
ADediting_1273227chr6_70588939_+SINEAluName=AluSp
ADediting_1273228chr6_70588940_+SINEAluName=AluSp
ADediting_1273229chr6_70588941_+SINEAluName=AluSp
ADediting_1273230chr6_70588942_+SINEAluName=AluSp
ADediting_1273231chr6_70588943_+SINEAluName=AluSp
ADediting_1273232chr6_70588945_+SINEAluName=AluSp
ADediting_1273233chr6_70588948_+SINEAluName=AluSp
ADediting_1273234chr6_70588949_+SINEAluName=AluSp
ADediting_1273235chr6_70588953_+SINEAluName=AluSp
ADediting_1273236chr6_70588957_+SINEAluName=AluSp
ADediting_1273237chr6_70588973_+SINEAluName=AluSp
ADediting_1273238chr6_70588979_+SINEAluName=AluSp
ADediting_1273239chr6_70588980_+SINEAluName=AluSp
ADediting_1273240chr6_70588985_+SINEAluName=AluSp
ADediting_1273241chr6_70588986_+SINEAluName=AluSp
ADediting_1273242chr6_70588989_+SINEAluName=AluSp
ADediting_1273243chr6_70589002_+SINEAluName=AluSp
ADediting_1273244chr6_70589006_+SINEAluName=AluSp
ADediting_1273245chr6_70589009_+SINEAluName=AluSp
ADediting_1273246chr6_70589012_+SINEAluName=AluSp
ADediting_1273247chr6_70589019_+SINEAluName=AluSp
ADediting_1273248chr6_70589020_+SINEAluName=AluSp
ADediting_1273249chr6_70589025_+SINEAluName=AluSp
ADediting_1273250chr6_70589045_+SINEAluName=AluSp
ADediting_1273251chr6_70589050_+SINEAluName=AluSp
ADediting_1273252chr6_70589085_+SINEAluName=AluSp
ADediting_1273253chr6_70589090_+SINEAluName=AluSp
ADediting_1273254chr6_70589101_+SINEAluName=AluSp
ADediting_1273255chr6_70589102_+SINEAluName=AluSp
ADediting_1273256chr6_70589103_+SINEAluName=AluSp
ADediting_1273257chr6_70589104_+SINEAluName=AluSp
ADediting_1273258chr6_70589105_+SINEAluName=AluSp
ADediting_1273259chr6_70589109_+SINEAluName=AluSp
ADediting_1273260chr6_70589186_+SINEAluName=AluSx1
ADediting_1273261chr6_70589188_+SINEAluName=AluSx1
ADediting_1273262chr6_70589208_+SINEAluName=AluSx1
ADediting_1273263chr6_70589220_+SINEAluName=AluSx1
ADediting_1273264chr6_70589226_+SINEAluName=AluSx1
ADediting_1273265chr6_70589229_+SINEAluName=AluSx1
ADediting_1273266chr6_70589234_+SINEAluName=AluSx1
ADediting_1273267chr6_70589235_+SINEAluName=AluSx1
ADediting_1273268chr6_70589239_+SINEAluName=AluSx1
ADediting_1273269chr6_70589245_+SINEAluName=AluSx1
ADediting_1273270chr6_70589259_+SINEAluName=AluSx1
ADediting_1273271chr6_70589265_+SINEAluName=AluSx1
ADediting_1273272chr6_70589266_+SINEAluName=AluSx1
ADediting_1273273chr6_70589269_+SINEAluName=AluSx1
ADediting_1273274chr6_70589270_+SINEAluName=AluSx1
ADediting_1273275chr6_70589283_+SINEAluName=AluSx1
ADediting_1273276chr6_70589295_+SINEAluName=AluSx1
ADediting_1273277chr6_70589305_+SINEAluName=AluSx1
ADediting_1273278chr6_70589307_+SINEAluName=AluSx1
ADediting_1273279chr6_70589331_+SINEAluName=AluSx1
ADediting_1273280chr6_70589332_+SINEAluName=AluSx1
ADediting_1273281chr6_70589340_+SINEAluName=AluSx1
ADediting_1273282chr6_70589346_+SINEAluName=AluSx1
ADediting_1273283chr6_70589349_+SINEAluName=AluSx1
ADediting_1273284chr6_70589350_+SINEAluName=AluSx1
ADediting_1273285chr6_70589351_+SINEAluName=AluSx1
ADediting_1273286chr6_70589353_+SINEAluName=AluSx1
ADediting_1273287chr6_70589355_+SINEAluName=AluSx1
ADediting_1273288chr6_70589356_+SINEAluName=AluSx1
ADediting_1273289chr6_70589363_+SINEAluName=AluSx1
ADediting_1273290chr6_70589371_+SINEAluName=AluSx1
ADediting_1273291chr6_70589375_+SINEAluName=AluSx1
ADediting_1273292chr6_70589400_+SINEAluName=AluSx1
ADediting_1273293chr6_70589418_+SINEAluName=AluSx1
ADediting_1273294chr6_70589427_+SINEAluName=AluSx1
ADediting_1273295chr6_70589428_+SINEAluName=AluSx1
ADediting_1273296chr6_70589449_+SINEAluName=AluSx1
ADediting_1584297chr6_70589070_+SINEAluName=AluSp
ADediting_1662261chr6_70588996_+SINEAluName=AluSp
ADediting_1662262chr6_70589065_+SINEAluName=AluSp
ADediting_1662263chr6_70589079_+SINEAluName=AluSp

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RNA A-to-I editing events in the alternative splicing sites for SDHAF4

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SDHAF4

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs