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Center for Computational Systems Medicine
Soverview

Gene summary

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RNA A-to-I events

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Differntial gene expression between RNA A-to-I edited versus non-edited samples

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Protein coding region RNA A-to-I editings

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The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

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Relation with ADAR

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Relation with AD stages

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Related drugs with this gene

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Related diseases with this gene


Gene summary for COX7A2

check button Gene summary
Gene informationGene symbol

COX7A2

Gene ID

1347

Gene namecytochrome c oxidase subunit 7A2
SynonymsCOX7AL|COX7AL1|COXVIIAL|COXVIIa-L|VIIAL
Cytomap

6q14.1

Type of geneprotein-coding
Descriptioncytochrome c oxidase subunit 7A2, mitochondrialcytochrome c oxidase polypeptide 7A2, mitochondrialcytochrome c oxidase polypeptide VIIa-liver/heartcytochrome c oxidase subunit VIIa polypeptide 2 (liver)cytochrome c oxidase subunit VIIa-Lcytochrome c
Modification date20200313
UniProtAcc

P14406,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for COX7A2

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
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check button RNA A-to-I editing events in AD.
ADediting_1275750(75238451, -), ADediting_1275751(75238463, -), ADediting_1275752(75238464, -), ADediting_1275753(75238491, -), ADediting_1275754(75238548, -), ADediting_1275755(75238572, -), ADediting_1275756(75238576, -), ADediting_1275757(75238582, -), ADediting_1275758(75238592, -), ADediting_1275759(75238604, -), ADediting_1275760(75238617, -), ADediting_1275761(75238621, -), ADediting_1275762(75238622, -), ADediting_1275763(75238641, -), ADediting_1275764(75238665, -), ADediting_1275765(75238849, -), ADediting_1275766(75238881, -), ADediting_1275767(75238883, -), ADediting_1275768(75238905, -), ADediting_1275769(75238912, -), ADediting_1275770(75238922, -), ADediting_1275771(75238926, -), ADediting_1275772(75238930, -), ADediting_1275773(75238935, -), ADediting_1275774(75238943, -), ADediting_1275775(75238947, -), ADediting_1275776(75238952, -), ADediting_1275777(75238953, -), ADediting_1275778(75238959, -), ADediting_1275779(75238963, -), ADediting_1275780(75238968, -), ADediting_1275781(75238979, -), ADediting_1275782(75238982, -), ADediting_1275783(75238985, -), ADediting_1275784(75238988, -), ADediting_1275785(75238990, -), ADediting_1275786(75238991, -), ADediting_1275787(75238992, -), ADediting_1275788(75238993, -), ADediting_1275789(75239008, -), ADediting_1275790(75239016, -), ADediting_1275791(75239034, -), ADediting_1275792(75239042, -), ADediting_1275793(75239052, -), ADediting_1275794(75239057, -), ADediting_1275795(75239989, -), ADediting_1275796(75240062, -), ADediting_1584468(75238486, -), ADediting_1584469(75238503, -), ADediting_1584470(75238892, -), ADediting_1584471(75238911, -), ADediting_1584472(75238936, -), ADediting_1584473(75238984, -), ADediting_1584474(75239047, -), ADediting_1584475(75239857, -), ADediting_1584476(75239936, -),

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RNA editing positional annotations for COX7A2 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1275750chr6_75238451_-intronic
ADediting_1275751chr6_75238463_-intronic
ADediting_1275752chr6_75238464_-intronic
ADediting_1275753chr6_75238491_-intronic
ADediting_1275754chr6_75238548_-intronic
ADediting_1275755chr6_75238572_-intronic
ADediting_1275756chr6_75238576_-intronic
ADediting_1275757chr6_75238582_-intronic
ADediting_1275758chr6_75238592_-intronic
ADediting_1275759chr6_75238604_-intronic
ADediting_1275760chr6_75238617_-intronic
ADediting_1275761chr6_75238621_-intronic
ADediting_1275762chr6_75238622_-intronic
ADediting_1275763chr6_75238641_-intronic
ADediting_1275764chr6_75238665_-intronic
ADediting_1275765chr6_75238849_-intronic
ADediting_1275766chr6_75238881_-intronic
ADediting_1275767chr6_75238883_-intronic
ADediting_1275768chr6_75238905_-intronic
ADediting_1275769chr6_75238912_-intronic
ADediting_1275770chr6_75238922_-intronic
ADediting_1275771chr6_75238926_-intronic
ADediting_1275772chr6_75238930_-intronic
ADediting_1275773chr6_75238935_-intronic
ADediting_1275774chr6_75238943_-intronic
ADediting_1275775chr6_75238947_-intronic
ADediting_1275776chr6_75238952_-intronic
ADediting_1275777chr6_75238953_-intronic
ADediting_1275778chr6_75238959_-intronic
ADediting_1275779chr6_75238963_-intronic
ADediting_1275780chr6_75238968_-intronic
ADediting_1275781chr6_75238979_-intronic
ADediting_1275782chr6_75238982_-intronic
ADediting_1275783chr6_75238985_-intronic
ADediting_1275784chr6_75238988_-intronic
ADediting_1275785chr6_75238990_-intronic
ADediting_1275786chr6_75238991_-intronic
ADediting_1275787chr6_75238992_-intronic
ADediting_1275788chr6_75238993_-intronic
ADediting_1275789chr6_75239008_-intronic
ADediting_1275790chr6_75239016_-intronic
ADediting_1275791chr6_75239034_-intronic
ADediting_1275792chr6_75239042_-intronic
ADediting_1275793chr6_75239052_-intronic
ADediting_1275794chr6_75239057_-intronic
ADediting_1275795chr6_75239989_-intronic
ADediting_1275796chr6_75240062_-intronic
ADediting_1584468chr6_75238486_-intronic
ADediting_1584469chr6_75238503_-intronic
ADediting_1584470chr6_75238892_-intronic
ADediting_1584471chr6_75238911_-intronic
ADediting_1584472chr6_75238936_-intronic
ADediting_1584473chr6_75238984_-intronic
ADediting_1584474chr6_75239047_-intronic
ADediting_1584475chr6_75239857_-intronic
ADediting_1584476chr6_75239936_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1275750chr6_75238451_-SINEAluName=AluSp
ADediting_1275751chr6_75238463_-SINEAluName=AluSp
ADediting_1275752chr6_75238464_-SINEAluName=AluSp
ADediting_1275753chr6_75238491_-SINEAluName=AluSp
ADediting_1275754chr6_75238548_-SINEAluName=AluSp
ADediting_1275755chr6_75238572_-SINEAluName=AluSp
ADediting_1275756chr6_75238576_-SINEAluName=AluSp
ADediting_1275757chr6_75238582_-SINEAluName=AluSp
ADediting_1275758chr6_75238592_-SINEAluName=AluSp
ADediting_1275759chr6_75238604_-SINEAluName=AluSp
ADediting_1275760chr6_75238617_-SINEAluName=AluSp
ADediting_1275761chr6_75238621_-SINEAluName=AluSp
ADediting_1275762chr6_75238622_-SINEAluName=AluSp
ADediting_1275763chr6_75238641_-SINEAluName=AluSp
ADediting_1275764chr6_75238665_-SINEAluName=AluSp
ADediting_1275765chr6_75238849_-SINEAluName=AluSx
ADediting_1275766chr6_75238881_-SINEAluName=AluSx
ADediting_1275767chr6_75238883_-SINEAluName=AluSx
ADediting_1275768chr6_75238905_-SINEAluName=AluSx
ADediting_1275769chr6_75238912_-SINEAluName=AluSx
ADediting_1275770chr6_75238922_-SINEAluName=AluSx
ADediting_1275771chr6_75238926_-SINEAluName=AluSx
ADediting_1275772chr6_75238930_-SINEAluName=AluSx
ADediting_1275773chr6_75238935_-SINEAluName=AluSx
ADediting_1275774chr6_75238943_-SINEAluName=AluSx
ADediting_1275775chr6_75238947_-SINEAluName=AluSx
ADediting_1275776chr6_75238952_-SINEAluName=AluSx
ADediting_1275777chr6_75238953_-SINEAluName=AluSx
ADediting_1275778chr6_75238959_-SINEAluName=AluSx
ADediting_1275779chr6_75238963_-SINEAluName=AluSx
ADediting_1275780chr6_75238968_-SINEAluName=AluSx
ADediting_1275781chr6_75238979_-SINEAluName=AluSx
ADediting_1275782chr6_75238982_-SINEAluName=AluSx
ADediting_1275783chr6_75238985_-SINEAluName=AluSx
ADediting_1275784chr6_75238988_-SINEAluName=AluSx
ADediting_1275785chr6_75238990_-SINEAluName=AluSx
ADediting_1275786chr6_75238991_-SINEAluName=AluSx
ADediting_1275787chr6_75238992_-SINEAluName=AluSx
ADediting_1275788chr6_75238993_-SINEAluName=AluSx
ADediting_1275789chr6_75239008_-SINEAluName=AluSx
ADediting_1275790chr6_75239016_-SINEAluName=AluSx
ADediting_1275791chr6_75239034_-SINEAluName=AluSx
ADediting_1275792chr6_75239042_-SINEAluName=AluSx
ADediting_1275793chr6_75239052_-SINEAluName=AluSx
ADediting_1275794chr6_75239057_-SINEAluName=AluSx
ADediting_1275795chr6_75239989_-SINEAluName=AluSp
ADediting_1275796chr6_75240062_-SINEAluName=AluSp
ADediting_1584468chr6_75238486_-SINEAluName=AluSp
ADediting_1584469chr6_75238503_-SINEAluName=AluSp
ADediting_1584470chr6_75238892_-SINEAluName=AluSx
ADediting_1584471chr6_75238911_-SINEAluName=AluSx
ADediting_1584472chr6_75238936_-SINEAluName=AluSx
ADediting_1584473chr6_75238984_-SINEAluName=AluSx
ADediting_1584474chr6_75239047_-SINEAluName=AluSx
ADediting_1584475chr6_75239857_-SINEAluName=AluSp
ADediting_1584476chr6_75239936_-SINEAluName=AluSp

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RNA A-to-I editing events in the alternative splicing sites for COX7A2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESADediting_1275756chr6_75238576_-75238573:752385815ss3iCAGGCATGC1.61CAGGCGTGC-1.29
ESADediting_1275761chr6_75238621_-75238621:752386295ss6iCAGGTTCAA1.19CAGGTTCAG2.78
ESADediting_1275762chr6_75238622_-75238621:752386295ss5iCAGGTTCAA1.19CAGGTTCGA5.36

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for COX7A2

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.
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check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for COX7A2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for COX7A2


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for COX7A2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for COX7A2

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_1275751chr6_75238463_-2.01731991211777e-060.2660719294870693.16962280113614e-080.3077695973871590.810210449614395-0.0136945446356193
CERADediting_1275767chr6_75238883_-0.006341663124666950.2219387133198072.93684961398274e-050.3340968169623220.9301079300481420.00722173355847445
TCXADediting_1275767chr6_75238883_-0.3439858410329220.07780027653108972.91264783308261e-060.3712353542262910.0226037592125319-0.186094107554649
CERADediting_1275773chr6_75238935_-0.004397601418647450.2313218264920310.0001504199004270110.304641981030380.5701184544754960.0467325623964754
CERADediting_1275777chr6_75238953_-0.001989261779255650.250504796714730.000157905696581730.3037173985426460.4393589144339290.0636058645837215
DLPFCADediting_1275778chr6_75238959_-1.13274502085037e-050.246481742145870.006278673883068710.154903908230527.40047547443253e-100.340575981957195
CERADediting_1275778chr6_75238959_-0.0002815319987429310.2924652855269131.52193889574651e-050.3451470064966190.85403696733955-0.0151469395271901
DLPFCADediting_1275779chr6_75238963_-2.93945302970733e-050.234920330999740.008297317897841610.1496854465702093.06173927588797e-090.32863214092638
DLPFCADediting_1275784chr6_75238988_-5.89704756710713e-050.2260964053117320.00173612673869090.1771924839979541.18573183560687e-080.316742123649947
DLPFCADediting_1275791chr6_75239034_-4.31879515803364e-090.325659784388513.20624120775672e-100.3473802298762219.88687648889045e-050.219315441108712
CERADediting_1275791chr6_75239034_-4.77312848413595e-050.3256530227814560.0003409812681395280.2886333222764650.538234116135246-0.0506455919814678
CERADediting_1275792chr6_75239042_-0.001255958066718260.2609930530317040.000118845607447170.3090842823175910.177249062890758-0.110755002921683
DLPFCADediting_1275793chr6_75239052_-2.87919762639155e-080.3086598609639141.65424341897855e-080.3137368185244272.76000241973196e-050.235702089368835
DLPFCADediting_1275794chr6_75239057_-6.16414173641546e-100.3420770611832231.1395465078903e-110.3730179329770121.27154079384556e-060.271056582900399

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC2.64410492560288e-300.5887282902860661.19654445889263e-240.5379154066969810.601314663184274-0.0297903829143489
AC5.66847703675281e-930.9030091673143871.03909261463621e-720.8551145626474065.04615703370383e-070.311404372034232
PCC7.80205714855317e-330.7281678436343325.91001171633958e-320.721181002966070.1240607301086130.111666873210446
CER0.0001141168749796660.3098427572416530.00968593390540350.2106023495994980.279066445320437-0.0889479126616164
TCX4.1740878161263e-130.5474814142642136.90216152645885e-170.6136340387118290.0038457370745054-0.234670242160948
FP0.003271964393330270.2192897631859078.29314146110249e-080.3886274877047060.000824777693823406-0.248476617948493
IFG0.4577147730592850.1555801391945030.7450834871050660.06845405252612620.00322790664772554-0.565371272531414
PG3.86331344420788e-370.765913394365894.36689872165564e-200.606731994169660.0553010031998156-0.140773288179937
STG5.54601624835389e-090.5838952262086562.0556467565635e-090.5969674691982330.0364080768841839-0.22868499729601

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Relation with AD stages for COX7A2

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
IFGADediting_1275773chr6_75238935_-0.03547133699799280.422303326441651

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.

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RelatedDrugs for COX7A2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COX7A2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource