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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

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Related drugs with this gene

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Related diseases with this gene


Gene summary for SLC9B2

check button Gene summary
Gene informationGene symbol

SLC9B2

Gene ID

133308

Gene namesolute carrier family 9 member B2
SynonymsNHA2|NHE10|NHEDC2
Cytomap

4q24

Type of geneprotein-coding
Descriptionsodium/hydrogen exchanger 9B2NHE domain-containing protein 2Na(+)/H(+) exchanger NHA2Na(+)/H(+) exchanger-like domain-containing protein 2Na+/H+ exchanger domain containing 2mitochondrial Na(+)/H(+) exchanger NHA2mitochondrial sodium/hydrogen exchan
Modification date20200313
UniProtAcc

Q86UD5,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
SLC9B2

GO:0006814

sodium ion transport

18508966


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RNA A-to-I events for SLC9B2

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1101284(103035205, -), ADediting_1101285(103035253, -), ADediting_1101286(103035261, -), ADediting_1101287(103035484, -), ADediting_1101288(103035501, -), ADediting_1101289(103035575, -), ADediting_1101290(103036301, -), ADediting_1101291(103036315, -), ADediting_1101292(103036508, -), ADediting_1101293(103053799, -), ADediting_1101294(103053800, -), ADediting_1101295(103057428, -), ADediting_1101296(103058889, -), ADediting_1101297(103058896, -), ADediting_1101298(103058927, -), ADediting_1101299(103059015, -), ADediting_1101300(103062164, -), ADediting_1101301(103062176, -), ADediting_1101302(103062177, -), ADediting_1101303(103062178, -), ADediting_1101304(103062204, -), ADediting_1101305(103062216, -), ADediting_1101306(103062238, -), ADediting_1101307(103062255, -), ADediting_1101308(103062258, -), ADediting_1101309(103062295, -), ADediting_1101310(103062297, -), ADediting_1101311(103062332, -), ADediting_1101312(103062333, -), ADediting_1101313(103062336, -), ADediting_1101314(103062337, -), ADediting_1101315(103062350, -), ADediting_1101316(103062713, -), ADediting_1101317(103062716, -), ADediting_1101318(103062722, -), ADediting_1101319(103062726, -), ADediting_1101320(103062735, -), ADediting_1101321(103062748, -), ADediting_1101322(103062749, -), ADediting_1101323(103062775, -), ADediting_1101324(103062811, -), ADediting_1101325(103062830, -), ADediting_1101326(103062831, -), ADediting_1101327(103062839, -), ADediting_1101328(103062869, -), ADediting_1101329(103062874, -), ADediting_1101330(103062882, -), ADediting_1101331(103062889, -), ADediting_1101332(103062899, -), ADediting_1101333(103062901, -), ADediting_1575918(103062779, -), ADediting_1575919(103062781, -), ADediting_1575920(103062785, -), ADediting_1575921(103062815, -), ADediting_1575922(103062847, -), ADediting_1575923(103062883, -), ADediting_1575924(103062890, -), ADediting_1649587(103035233, -), ADediting_1649588(103035290, -), ADediting_1649589(103036229, -), ADediting_1649590(103036259, -), ADediting_1649591(103036263, -), ADediting_1649592(103058526, -), ADediting_1649593(103058536, -), ADediting_1649594(103058621, -), ADediting_1649595(103058628, -), ADediting_1649596(103058658, -), ADediting_1649597(103062739, -),

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RNA editing positional annotations for SLC9B2 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1101284chr4_103035205_-intronic
ADediting_1101285chr4_103035253_-intronic
ADediting_1101286chr4_103035261_-intronic
ADediting_1101287chr4_103035484_-intronic
ADediting_1101288chr4_103035501_-intronic
ADediting_1101289chr4_103035575_-intronic
ADediting_1101290chr4_103036301_-intronic
ADediting_1101291chr4_103036315_-intronic
ADediting_1101292chr4_103036508_-intronic
ADediting_1101293chr4_103053799_-intronic
ADediting_1101294chr4_103053800_-intronic
ADediting_1101295chr4_103057428_-intronic
ADediting_1101296chr4_103058889_-intronic
ADediting_1101297chr4_103058896_-intronic
ADediting_1101298chr4_103058927_-intronic
ADediting_1101299chr4_103059015_-intronic
ADediting_1101300chr4_103062164_-intronic
ADediting_1101301chr4_103062176_-intronic
ADediting_1101302chr4_103062177_-intronic
ADediting_1101303chr4_103062178_-intronic
ADediting_1101304chr4_103062204_-intronic
ADediting_1101305chr4_103062216_-intronic
ADediting_1101306chr4_103062238_-intronic
ADediting_1101307chr4_103062255_-intronic
ADediting_1101308chr4_103062258_-intronic
ADediting_1101309chr4_103062295_-intronic
ADediting_1101310chr4_103062297_-intronic
ADediting_1101311chr4_103062332_-intronic
ADediting_1101312chr4_103062333_-intronic
ADediting_1101313chr4_103062336_-intronic
ADediting_1101314chr4_103062337_-intronic
ADediting_1101315chr4_103062350_-intronic
ADediting_1101316chr4_103062713_-intronic
ADediting_1101317chr4_103062716_-intronic
ADediting_1101318chr4_103062722_-intronic
ADediting_1101319chr4_103062726_-intronic
ADediting_1101320chr4_103062735_-intronic
ADediting_1101321chr4_103062748_-intronic
ADediting_1101322chr4_103062749_-intronic
ADediting_1101323chr4_103062775_-intronic
ADediting_1101324chr4_103062811_-intronic
ADediting_1101325chr4_103062830_-intronic
ADediting_1101326chr4_103062831_-intronic
ADediting_1101327chr4_103062839_-intronic
ADediting_1101328chr4_103062869_-intronic
ADediting_1101329chr4_103062874_-intronic
ADediting_1101330chr4_103062882_-intronic
ADediting_1101331chr4_103062889_-intronic
ADediting_1101332chr4_103062899_-intronic
ADediting_1101333chr4_103062901_-intronic
ADediting_1575918chr4_103062779_-intronic
ADediting_1575919chr4_103062781_-intronic
ADediting_1575920chr4_103062785_-intronic
ADediting_1575921chr4_103062815_-intronic
ADediting_1575922chr4_103062847_-intronic
ADediting_1575923chr4_103062883_-intronic
ADediting_1575924chr4_103062890_-intronic
ADediting_1649587chr4_103035233_-intronic
ADediting_1649588chr4_103035290_-intronic
ADediting_1649589chr4_103036229_-intronic
ADediting_1649590chr4_103036259_-intronic
ADediting_1649591chr4_103036263_-intronic
ADediting_1649592chr4_103058526_-intronic
ADediting_1649593chr4_103058536_-intronic
ADediting_1649594chr4_103058621_-intronic
ADediting_1649595chr4_103058628_-intronic
ADediting_1649596chr4_103058658_-intronic
ADediting_1649597chr4_103062739_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1101284chr4_103035205_-LINEL1Name=L1PA13
ADediting_1101285chr4_103035253_-LINEL1Name=L1PA13
ADediting_1101286chr4_103035261_-LINEL1Name=L1PA13
ADediting_1101287chr4_103035484_-LINEL1Name=L1PA13
ADediting_1101288chr4_103035501_-LINEL1Name=L1PA13
ADediting_1101289chr4_103035575_-LINEL1Name=L1PA13
ADediting_1101290chr4_103036301_-LINEL1Name=L1PA15
ADediting_1101291chr4_103036315_-LINEL1Name=L1PA15
ADediting_1101292chr4_103036508_-LINEL1Name=L1PA15
ADediting_1101293chr4_103053799_-SINEAluName=AluSc
ADediting_1101294chr4_103053800_-SINEAluName=AluSc
ADediting_1101295chr4_103057428_-SINEAluName=AluJb
ADediting_1101296chr4_103058889_-SINEAluName=AluJo
ADediting_1101297chr4_103058896_-SINEAluName=AluJo
ADediting_1101298chr4_103058927_-SINEAluName=AluJo
ADediting_1101299chr4_103059015_-SINEAluName=AluJo
ADediting_1101300chr4_103062164_-SINEAluName=AluSg
ADediting_1101301chr4_103062176_-SINEAluName=AluSg
ADediting_1101302chr4_103062177_-SINEAluName=AluSg
ADediting_1101303chr4_103062178_-SINEAluName=AluSg
ADediting_1101304chr4_103062204_-SINEAluName=AluSg
ADediting_1101305chr4_103062216_-SINEAluName=AluSg
ADediting_1101306chr4_103062238_-SINEAluName=AluSg
ADediting_1101307chr4_103062255_-SINEAluName=AluSg
ADediting_1101308chr4_103062258_-SINEAluName=AluSg
ADediting_1101309chr4_103062295_-SINEAluName=AluSg
ADediting_1101310chr4_103062297_-SINEAluName=AluSg
ADediting_1101311chr4_103062332_-SINEAluName=AluSg
ADediting_1101312chr4_103062333_-SINEAluName=AluSg
ADediting_1101313chr4_103062336_-SINEAluName=AluSg
ADediting_1101314chr4_103062337_-SINEAluName=AluSg
ADediting_1101315chr4_103062350_-SINEAluName=AluSg
ADediting_1101316chr4_103062713_-SINEAluName=AluSq2
ADediting_1101317chr4_103062716_-SINEAluName=AluSq2
ADediting_1101318chr4_103062722_-SINEAluName=AluSq2
ADediting_1101319chr4_103062726_-SINEAluName=AluSq2
ADediting_1101320chr4_103062735_-SINEAluName=AluSq2
ADediting_1101321chr4_103062748_-SINEAluName=AluSq2
ADediting_1101322chr4_103062749_-SINEAluName=AluSq2
ADediting_1101323chr4_103062775_-SINEAluName=AluSq2
ADediting_1101324chr4_103062811_-SINEAluName=AluSq2
ADediting_1101325chr4_103062830_-SINEAluName=AluSq2
ADediting_1101326chr4_103062831_-SINEAluName=AluSq2
ADediting_1101327chr4_103062839_-SINEAluName=AluSq2
ADediting_1101328chr4_103062869_-SINEAluName=AluSq2
ADediting_1101329chr4_103062874_-SINEAluName=AluSq2
ADediting_1101330chr4_103062882_-SINEAluName=AluSq2
ADediting_1101331chr4_103062889_-SINEAluName=AluSq2
ADediting_1101332chr4_103062899_-SINEAluName=AluSq2
ADediting_1101333chr4_103062901_-SINEAluName=AluSq2
ADediting_1575918chr4_103062779_-SINEAluName=AluSq2
ADediting_1575919chr4_103062781_-SINEAluName=AluSq2
ADediting_1575920chr4_103062785_-SINEAluName=AluSq2
ADediting_1575921chr4_103062815_-SINEAluName=AluSq2
ADediting_1575922chr4_103062847_-SINEAluName=AluSq2
ADediting_1575923chr4_103062883_-SINEAluName=AluSq2
ADediting_1575924chr4_103062890_-SINEAluName=AluSq2
ADediting_1649587chr4_103035233_-LINEL1Name=L1PA13
ADediting_1649588chr4_103035290_-LINEL1Name=L1PA13
ADediting_1649589chr4_103036229_-LINEL1Name=L1PA15
ADediting_1649590chr4_103036259_-LINEL1Name=L1PA15
ADediting_1649591chr4_103036263_-LINEL1Name=L1PA15
ADediting_1649592chr4_103058526_-SINEAluName=AluJb
ADediting_1649593chr4_103058536_-SINEAluName=AluJb
ADediting_1649594chr4_103058621_-SINEAluName=AluJb
ADediting_1649595chr4_103058628_-SINEAluName=AluJb
ADediting_1649596chr4_103058658_-SINEAluName=AluJb
ADediting_1649597chr4_103062739_-SINEAluName=AluSq2

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RNA A-to-I editing events in the alternative splicing sites for SLC9B2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SLC9B2

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for SLC9B2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for SLC9B2


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000164038.16ENST00000394785.9SLC9B2-202hsa-miR-5688chr41030234841030234918mer-1a103023484103023505150-19.15
ADediting_1391023chr8_140732605_-ENSG00000164038.16ENST00000394785.9SLC9B2-202hsa-miR-151a-3pchr41030241661030241738mer-1a103024166103024187162-24.44
ADediting_1471003chr9_63819626_+ENSG00000164038.16ENST00000394785.9SLC9B2-202hsa-miR-4477bchr41030226361030226438mer-1a103022625103022645147-13.81
ADediting_1471003chr9_63819626_+ENSG00000164038.16ENST00000394785.9SLC9B2-202hsa-miR-4477bchr41030226361030226438mer-1a103022636103022656162-18.93
ADediting_1556067chr19_40282625_-ENSG00000164038.16ENST00000362026.7SLC9B2-201hsa-miR-641chr41030201691030201768mer-1a103020169103020191157-17.55
ADediting_1631458chr19_40282624_-ENSG00000164038.16ENST00000394785.9SLC9B2-202hsa-miR-641chr41030226401030226467mer-m8103022639103022662161-18.63
ADediting_843620chr2_207754818_+ENSG00000164038.16ENST00000394785.9SLC9B2-202hsa-miR-4775chr41030253361030253427mer-m8103025335103025356148-7.59
ADediting_98289chr1_32086992_+ENSG00000164038.16ENST00000394785.9SLC9B2-202hsa-miR-5585-3pchr41030235181030235247mer-m8103023517103023537146-17.38

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1471003chr9_63819626_+ENSG00000164038.16ENST00000394785.9SLC9B2-202hsa-miR-4477bchr41030241821030241887mer-m8103024181103024202154-11.34
ADediting_1471004chr9_63819627_+ENSG00000164038.16ENST00000394785.9SLC9B2-202hsa-miR-4477bchr41030241821030241887mer-m8103024181103024202154-11.34
ADediting_843620chr2_207754818_+ENSG00000164038.16ENST00000394785.9SLC9B2-202hsa-miR-4775chr41030238121030238187mer-m8103023811103023831145-12.22
ADediting_98288chr1_32086990_+ENSG00000164038.16ENST00000394785.9SLC9B2-202hsa-miR-5585-3pchr41030244961030245038mer-1a103024496103024517146-10.56
ADediting_98289chr1_32086992_+ENSG00000164038.16ENST00000394785.9SLC9B2-202hsa-miR-5585-3pchr41030244961030245038mer-1a103024496103024517146-10.56

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SLC9B2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for SLC9B2

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_1101293chr4_103053799_-0.384702201365874-0.04954074475652440.0494337731664347-0.1116967050650491.31800817019705e-120.388460981495769

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC1.69335551345046e-830.8392658208075581.27379436682028e-510.7240879136892870.910576063692430.00640469837608123
AC4.74177593298948e-990.913842220170026.1376562726332e-660.8338282663569390.000159891917727760.236551415561054
PCC1.29921890186008e-670.8934557658059264.48870754888921e-720.90499712877240.4159828481038720.0591932361611345
CER3.92497194197136e-360.8100541678278119.09616213990491e-150.5784020301735070.8219095355075760.0185319426066584
TCX1.83697384229544e-250.7221699745526691.30332811008339e-160.6092836082256070.1731981632099-0.111793038235827
FP5.26403271733744e-120.4873198264713371.46516860719421e-220.6478347210854160.221401360199598-0.0921074616231553
IFG0.001652192922012850.5963916828900480.02503510755879220.4471110086452560.227161341215464-0.250490834914771
PG3.61610049498332e-270.685617740688877.06546260428034e-320.7271135842279690.000850603761356712-0.242563296516944
STG6.72385640011529e-180.7732698029530411.08264042398595e-180.7844313181554180.206571305481892-0.139223862842107

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Relation with AD stages for SLC9B2

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.

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RelatedDrugs for SLC9B2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC9B2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource