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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for COPA |
 Gene summary |
| Gene information | Gene symbol | COPA | Gene ID | 1314 |
| Gene name | COPI coat complex subunit alpha | |
| Synonyms | AILJK|HEP-COP|alpha-COP | |
| Cytomap | 1q23.2 | |
| Type of gene | protein-coding | |
| Description | coatomer subunit alphaalpha coat proteincoatomer protein complex subunit alphaproxeninxenin | |
| Modification date | 20200327 | |
| UniProtAcc | P53621, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| COPA | GO:0030157 | pancreatic juice secretion | 1429581 |
Top |
RNA A-to-I events for COPA |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_37002(160288976, -), ADediting_37003(160302652, -), ADediting_37004(160302693, -), ADediting_37005(160302729, -), ADediting_37006(160302757, -), ADediting_37007(160302759, -), ADediting_37008(160302826, -), ADediting_37009(160302910, -), ADediting_37010(160302928, -), ADediting_37011(160302943, -), ADediting_37012(160302981, -), ADediting_37013(160302988, -), ADediting_37014(160302990, -), ADediting_37015(160302993, -), ADediting_37016(160303033, -), ADediting_37017(160303152, -), ADediting_37018(160303163, -), ADediting_37019(160304100, -), ADediting_37020(160304111, -), ADediting_37021(160304117, -), ADediting_37022(160304126, -), ADediting_37023(160304130, -), ADediting_37024(160304143, -), ADediting_37025(160304147, -), ADediting_37026(160304152, -), ADediting_37027(160304153, -), ADediting_37028(160304178, -), ADediting_37029(160304208, -), ADediting_37030(160304221, -), ADediting_37031(160304232, -), ADediting_37032(160304260, -), ADediting_37033(160304281, -), ADediting_37034(160304286, -), ADediting_37035(160304287, -), ADediting_37036(160304409, -), ADediting_37037(160304421, -), ADediting_37038(160304422, -), ADediting_37039(160304436, -), ADediting_37040(160304501, -), ADediting_37041(160304542, -), ADediting_37042(160304552, -), ADediting_37043(160304564, -), ADediting_37044(160304577, -), ADediting_37045(160304581, -), ADediting_37046(160304582, -), ADediting_37047(160304601, -), ADediting_37048(160304602, -), ADediting_37049(160304617, -), ADediting_37050(160304652, -), ADediting_37051(160313685, -), ADediting_37052(160314506, -), ADediting_37053(160314624, -), ADediting_37054(160324066, -), ADediting_37055(160324106, -), ADediting_37056(160324577, -), ADediting_37057(160326276, -), ADediting_37058(160326292, -), ADediting_37059(160326309, -), ADediting_37060(160326310, -), ADediting_37061(160326372, -), ADediting_37062(160326403, -), ADediting_37063(160326521, -), ADediting_37064(160326734, -), ADediting_37065(160326738, -), ADediting_37066(160326744, -), ADediting_37067(160326756, -), ADediting_37068(160326757, -), ADediting_37069(160326761, -), ADediting_37070(160328044, -), ADediting_37071(160328045, -), ADediting_37072(160328061, -), ADediting_37073(160328085, -), ADediting_37074(160332454, -), ADediting_37075(160333010, -), ADediting_37076(160333056, -), ADediting_37077(160333062, -), ADediting_37078(160333064, -), ADediting_37079(160333089, -), ADediting_37080(160333117, -), ADediting_37081(160333125, -), ADediting_37082(160333127, -), ADediting_37083(160333137, -), ADediting_37084(160333161, -), ADediting_37085(160333166, -), ADediting_37086(160333191, -), ADediting_37087(160333196, -), ADediting_37088(160333197, -), ADediting_37089(160333212, -), ADediting_37090(160337463, -), ADediting_1515935(160326419, -), ADediting_1515936(160328125, -), ADediting_1515937(160328484, -), ADediting_1515938(160333091, -), ADediting_1515939(160333094, -), ADediting_1515940(160333095, -), ADediting_1515941(160333170, -), ADediting_1515942(160333174, -), ADediting_1596742(160289683, -), ADediting_1596743(160289731, -), ADediting_1596744(160289742, -), ADediting_1596745(160289747, -), ADediting_1596746(160289755, -), ADediting_1596747(160304481, -), ADediting_1596748(160331026, -), ADediting_1596749(160333052, -), ADediting_1596750(160333088, -), |
Top |
RNA editing positional annotations for COPA using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_37074 | chr1_160332454_- | nonsynonymous SNV | ENST00000649676.1 | c.A37G | p.I13V | 0.022 | 0.021 | -0.84 |
| ADediting_37074 | chr1_160332454_- | nonsynonymous SNV | ENST00000649787.1 | c.A490G | p.I164V | 0.022 | 0.021 | -0.84 |
| ADediting_37074 | chr1_160332454_- | nonsynonymous SNV | ENST00000241704.8 | c.A490G | p.I164V | 0.022 | 0.021 | -0.84 |
| ADediting_37074 | chr1_160332454_- | nonsynonymous SNV | ENST00000648805.1 | c.A490G | p.I164V | 0.022 | 0.021 | -0.84 |
| ADediting_37074 | chr1_160332454_- | nonsynonymous SNV | ENST00000647799.1 | c.A413G | p.Y138C | 0.022 | 0.021 | -0.84 |
| ADediting_37074 | chr1_160332454_- | nonsynonymous SNV | ENST00000647683.1 | c.A490G | p.I164V | 0.022 | 0.021 | -0.84 |
| ADediting_37074 | chr1_160332454_- | nonsynonymous SNV | ENST00000368069.7 | c.A490G | p.I164V | 0.022 | 0.021 | -0.84 |
| ADediting_37074 | chr1_160332454_- | nonsynonymous SNV | ENST00000650154.1 | c.A332G | p.Y111C | 0.022 | 0.021 | -0.84 |
| ADediting_37074 | chr1_160332454_- | nonsynonymous SNV | ENST00000649231.1 | c.A490G | p.I164V | 0.022 | 0.021 | -0.84 |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_37002 | chr1_160288976_- | UTR3 |
| ADediting_37003 | chr1_160302652_- | intronic |
| ADediting_37004 | chr1_160302693_- | intronic |
| ADediting_37005 | chr1_160302729_- | intronic |
| ADediting_37006 | chr1_160302757_- | intronic |
| ADediting_37007 | chr1_160302759_- | intronic |
| ADediting_37008 | chr1_160302826_- | intronic |
| ADediting_37009 | chr1_160302910_- | intronic |
| ADediting_37010 | chr1_160302928_- | intronic |
| ADediting_37011 | chr1_160302943_- | intronic |
| ADediting_37012 | chr1_160302981_- | intronic |
| ADediting_37013 | chr1_160302988_- | intronic |
| ADediting_37014 | chr1_160302990_- | intronic |
| ADediting_37015 | chr1_160302993_- | intronic |
| ADediting_37016 | chr1_160303033_- | intronic |
| ADediting_37017 | chr1_160303152_- | intronic |
| ADediting_37018 | chr1_160303163_- | intronic |
| ADediting_37019 | chr1_160304100_- | intronic |
| ADediting_37020 | chr1_160304111_- | intronic |
| ADediting_37021 | chr1_160304117_- | intronic |
| ADediting_37022 | chr1_160304126_- | intronic |
| ADediting_37023 | chr1_160304130_- | intronic |
| ADediting_37024 | chr1_160304143_- | intronic |
| ADediting_37025 | chr1_160304147_- | intronic |
| ADediting_37026 | chr1_160304152_- | intronic |
| ADediting_37027 | chr1_160304153_- | intronic |
| ADediting_37028 | chr1_160304178_- | intronic |
| ADediting_37029 | chr1_160304208_- | intronic |
| ADediting_37030 | chr1_160304221_- | intronic |
| ADediting_37031 | chr1_160304232_- | intronic |
| ADediting_37032 | chr1_160304260_- | intronic |
| ADediting_37033 | chr1_160304281_- | intronic |
| ADediting_37034 | chr1_160304286_- | intronic |
| ADediting_37035 | chr1_160304287_- | intronic |
| ADediting_37036 | chr1_160304409_- | intronic |
| ADediting_37037 | chr1_160304421_- | intronic |
| ADediting_37038 | chr1_160304422_- | intronic |
| ADediting_37039 | chr1_160304436_- | intronic |
| ADediting_37040 | chr1_160304501_- | intronic |
| ADediting_37041 | chr1_160304542_- | intronic |
| ADediting_37042 | chr1_160304552_- | intronic |
| ADediting_37043 | chr1_160304564_- | intronic |
| ADediting_37044 | chr1_160304577_- | intronic |
| ADediting_37045 | chr1_160304581_- | intronic |
| ADediting_37046 | chr1_160304582_- | intronic |
| ADediting_37047 | chr1_160304601_- | intronic |
| ADediting_37048 | chr1_160304602_- | intronic |
| ADediting_37049 | chr1_160304617_- | intronic |
| ADediting_37050 | chr1_160304652_- | intronic |
| ADediting_37051 | chr1_160313685_- | intronic |
| ADediting_37052 | chr1_160314506_- | intronic |
| ADediting_37053 | chr1_160314624_- | intronic |
| ADediting_37054 | chr1_160324066_- | intronic |
| ADediting_37055 | chr1_160324106_- | intronic |
| ADediting_37056 | chr1_160324577_- | intronic |
| ADediting_37057 | chr1_160326276_- | intronic |
| ADediting_37058 | chr1_160326292_- | intronic |
| ADediting_37059 | chr1_160326309_- | intronic |
| ADediting_37060 | chr1_160326310_- | intronic |
| ADediting_37061 | chr1_160326372_- | intronic |
| ADediting_37062 | chr1_160326403_- | intronic |
| ADediting_37063 | chr1_160326521_- | intronic |
| ADediting_37064 | chr1_160326734_- | intronic |
| ADediting_37065 | chr1_160326738_- | intronic |
| ADediting_37066 | chr1_160326744_- | intronic |
| ADediting_37067 | chr1_160326756_- | intronic |
| ADediting_37068 | chr1_160326757_- | intronic |
| ADediting_37069 | chr1_160326761_- | intronic |
| ADediting_37070 | chr1_160328044_- | intronic |
| ADediting_37071 | chr1_160328045_- | intronic |
| ADediting_37072 | chr1_160328061_- | intronic |
| ADediting_37073 | chr1_160328085_- | intronic |
| ADediting_37074 | chr1_160332454_- | exonic |
| ADediting_37075 | chr1_160333010_- | intronic |
| ADediting_37076 | chr1_160333056_- | intronic |
| ADediting_37077 | chr1_160333062_- | intronic |
| ADediting_37078 | chr1_160333064_- | intronic |
| ADediting_37079 | chr1_160333089_- | intronic |
| ADediting_37080 | chr1_160333117_- | intronic |
| ADediting_37081 | chr1_160333125_- | intronic |
| ADediting_37082 | chr1_160333127_- | intronic |
| ADediting_37083 | chr1_160333137_- | intronic |
| ADediting_37084 | chr1_160333161_- | intronic |
| ADediting_37085 | chr1_160333166_- | intronic |
| ADediting_37086 | chr1_160333191_- | intronic |
| ADediting_37087 | chr1_160333196_- | intronic |
| ADediting_37088 | chr1_160333197_- | intronic |
| ADediting_37089 | chr1_160333212_- | intronic |
| ADediting_37090 | chr1_160337463_- | intronic |
| ADediting_1515935 | chr1_160326419_- | intronic |
| ADediting_1515936 | chr1_160328125_- | intronic |
| ADediting_1515937 | chr1_160328484_- | intronic |
| ADediting_1515938 | chr1_160333091_- | intronic |
| ADediting_1515939 | chr1_160333094_- | intronic |
| ADediting_1515940 | chr1_160333095_- | intronic |
| ADediting_1515941 | chr1_160333170_- | intronic |
| ADediting_1515942 | chr1_160333174_- | intronic |
| ADediting_1596742 | chr1_160289683_- | UTR3 |
| ADediting_1596743 | chr1_160289731_- | UTR3 |
| ADediting_1596744 | chr1_160289742_- | UTR3 |
| ADediting_1596745 | chr1_160289747_- | UTR3 |
| ADediting_1596746 | chr1_160289755_- | UTR3 |
| ADediting_1596747 | chr1_160304481_- | intronic |
| ADediting_1596748 | chr1_160331026_- | intronic |
| ADediting_1596749 | chr1_160333052_- | intronic |
| ADediting_1596750 | chr1_160333088_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_37002 | chr1_160288976_- | SINE | Alu | Name=AluSg7 |
| ADediting_37003 | chr1_160302652_- | SINE | Alu | Name=AluY |
| ADediting_37004 | chr1_160302693_- | SINE | Alu | Name=AluY |
| ADediting_37005 | chr1_160302729_- | SINE | Alu | Name=AluY |
| ADediting_37006 | chr1_160302757_- | SINE | Alu | Name=AluY |
| ADediting_37007 | chr1_160302759_- | SINE | Alu | Name=AluY |
| ADediting_37008 | chr1_160302826_- | SINE | Alu | Name=AluY |
| ADediting_37009 | chr1_160302910_- | SINE | Alu | Name=AluSz |
| ADediting_37010 | chr1_160302928_- | SINE | Alu | Name=AluSz |
| ADediting_37011 | chr1_160302943_- | SINE | Alu | Name=AluSz |
| ADediting_37012 | chr1_160302981_- | SINE | Alu | Name=AluSz |
| ADediting_37013 | chr1_160302988_- | SINE | Alu | Name=AluSz |
| ADediting_37014 | chr1_160302990_- | SINE | Alu | Name=AluSz |
| ADediting_37015 | chr1_160302993_- | SINE | Alu | Name=AluSz |
| ADediting_37016 | chr1_160303033_- | SINE | Alu | Name=AluSz |
| ADediting_37017 | chr1_160303152_- | SINE | Alu | Name=AluSz |
| ADediting_37018 | chr1_160303163_- | SINE | Alu | Name=AluSz |
| ADediting_37019 | chr1_160304100_- | SINE | Alu | Name=AluSp |
| ADediting_37020 | chr1_160304111_- | SINE | Alu | Name=AluSp |
| ADediting_37021 | chr1_160304117_- | SINE | Alu | Name=AluSp |
| ADediting_37022 | chr1_160304126_- | SINE | Alu | Name=AluSp |
| ADediting_37023 | chr1_160304130_- | SINE | Alu | Name=AluSp |
| ADediting_37024 | chr1_160304143_- | SINE | Alu | Name=AluSp |
| ADediting_37025 | chr1_160304147_- | SINE | Alu | Name=AluSp |
| ADediting_37026 | chr1_160304152_- | SINE | Alu | Name=AluSp |
| ADediting_37027 | chr1_160304153_- | SINE | Alu | Name=AluSp |
| ADediting_37028 | chr1_160304178_- | SINE | Alu | Name=AluSp |
| ADediting_37029 | chr1_160304208_- | SINE | Alu | Name=AluSp |
| ADediting_37030 | chr1_160304221_- | SINE | Alu | Name=AluSp |
| ADediting_37031 | chr1_160304232_- | SINE | Alu | Name=AluSp |
| ADediting_37032 | chr1_160304260_- | SINE | Alu | Name=AluSp |
| ADediting_37033 | chr1_160304281_- | SINE | Alu | Name=AluSp |
| ADediting_37034 | chr1_160304286_- | SINE | Alu | Name=AluSp |
| ADediting_37035 | chr1_160304287_- | SINE | Alu | Name=AluSp |
| ADediting_37036 | chr1_160304409_- | SINE | Alu | Name=AluSg |
| ADediting_37037 | chr1_160304421_- | SINE | Alu | Name=AluSg |
| ADediting_37038 | chr1_160304422_- | SINE | Alu | Name=AluSg |
| ADediting_37039 | chr1_160304436_- | SINE | Alu | Name=AluSg |
| ADediting_37040 | chr1_160304501_- | SINE | Alu | Name=AluSg |
| ADediting_37041 | chr1_160304542_- | SINE | Alu | Name=AluSg |
| ADediting_37042 | chr1_160304552_- | SINE | Alu | Name=AluSg |
| ADediting_37043 | chr1_160304564_- | SINE | Alu | Name=AluSg |
| ADediting_37044 | chr1_160304577_- | SINE | Alu | Name=AluSg |
| ADediting_37045 | chr1_160304581_- | SINE | Alu | Name=AluSg |
| ADediting_37046 | chr1_160304582_- | SINE | Alu | Name=AluSg |
| ADediting_37047 | chr1_160304601_- | SINE | Alu | Name=AluSg |
| ADediting_37048 | chr1_160304602_- | SINE | Alu | Name=AluSg |
| ADediting_37049 | chr1_160304617_- | SINE | Alu | Name=AluSg |
| ADediting_37050 | chr1_160304652_- | SINE | Alu | Name=AluSg |
| ADediting_37051 | chr1_160313685_- | SINE | Alu | Name=AluY |
| ADediting_37052 | chr1_160314506_- | SINE | Alu | Name=AluJb |
| ADediting_37053 | chr1_160314624_- | SINE | Alu | Name=AluJb |
| ADediting_37054 | chr1_160324066_- | SINE | Alu | Name=AluSg7 |
| ADediting_37055 | chr1_160324106_- | SINE | Alu | Name=AluSg7 |
| ADediting_37056 | chr1_160324577_- | SINE | Alu | Name=AluJr |
| ADediting_37057 | chr1_160326276_- | SINE | Alu | Name=AluJb |
| ADediting_37058 | chr1_160326292_- | SINE | Alu | Name=AluJb |
| ADediting_37059 | chr1_160326309_- | SINE | Alu | Name=AluJb |
| ADediting_37060 | chr1_160326310_- | SINE | Alu | Name=AluJb |
| ADediting_37061 | chr1_160326372_- | SINE | Alu | Name=AluJb |
| ADediting_37062 | chr1_160326403_- | SINE | Alu | Name=AluJb |
| ADediting_37063 | chr1_160326521_- | SINE | Alu | Name=AluJb |
| ADediting_37075 | chr1_160333010_- | SINE | Alu | Name=AluSx |
| ADediting_37076 | chr1_160333056_- | SINE | Alu | Name=AluSx |
| ADediting_37077 | chr1_160333062_- | SINE | Alu | Name=AluSx |
| ADediting_37078 | chr1_160333064_- | SINE | Alu | Name=AluSx |
| ADediting_37079 | chr1_160333089_- | SINE | Alu | Name=AluSx |
| ADediting_37080 | chr1_160333117_- | SINE | Alu | Name=AluSx |
| ADediting_37081 | chr1_160333125_- | SINE | Alu | Name=AluSx |
| ADediting_37082 | chr1_160333127_- | SINE | Alu | Name=AluSx |
| ADediting_37083 | chr1_160333137_- | SINE | Alu | Name=AluSx |
| ADediting_37084 | chr1_160333161_- | SINE | Alu | Name=AluSx |
| ADediting_37085 | chr1_160333166_- | SINE | Alu | Name=AluSx |
| ADediting_37086 | chr1_160333191_- | SINE | Alu | Name=AluSx |
| ADediting_37087 | chr1_160333196_- | SINE | Alu | Name=AluSx |
| ADediting_37088 | chr1_160333197_- | SINE | Alu | Name=AluSx |
| ADediting_37089 | chr1_160333212_- | SINE | Alu | Name=AluSx |
| ADediting_37090 | chr1_160337463_- | SINE | Alu | Name=AluSx |
| ADediting_1515935 | chr1_160326419_- | SINE | Alu | Name=AluJb |
| ADediting_1515938 | chr1_160333091_- | SINE | Alu | Name=AluSx |
| ADediting_1515939 | chr1_160333094_- | SINE | Alu | Name=AluSx |
| ADediting_1515940 | chr1_160333095_- | SINE | Alu | Name=AluSx |
| ADediting_1515941 | chr1_160333170_- | SINE | Alu | Name=AluSx |
| ADediting_1515942 | chr1_160333174_- | SINE | Alu | Name=AluSx |
| ADediting_1596742 | chr1_160289683_- | SINE | Alu | Name=AluSz6 |
| ADediting_1596743 | chr1_160289731_- | SINE | Alu | Name=AluSz6 |
| ADediting_1596744 | chr1_160289742_- | SINE | Alu | Name=AluSz6 |
| ADediting_1596745 | chr1_160289747_- | SINE | Alu | Name=AluSz6 |
| ADediting_1596746 | chr1_160289755_- | SINE | Alu | Name=AluSz6 |
| ADediting_1596747 | chr1_160304481_- | SINE | Alu | Name=AluSg |
| ADediting_1596748 | chr1_160331026_- | SINE | Alu | Name=AluSx |
| ADediting_1596749 | chr1_160333052_- | SINE | Alu | Name=AluSx |
| ADediting_1596750 | chr1_160333088_- | SINE | Alu | Name=AluSx |
Top |
RNA A-to-I editing events in the alternative splicing sites for COPA |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for COPA |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |