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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for DUSP15 |
 Gene summary |
| Gene information | Gene symbol | DUSP15 | Gene ID | 128853 |
| Gene name | dual specificity phosphatase 15 | |
| Synonyms | C20orf57|VHY | |
| Cytomap | 20q11.21 | |
| Type of gene | protein-coding | |
| Description | dual specificity protein phosphatase 15VH1-related member Ydual specificity phosphatase-like 15vaccinia virus VH1-related dual-specific protein phosphatase Y | |
| Modification date | 20200313 | |
| UniProtAcc | Q9H1R2, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| DUSP15 | GO:0016311 | dephosphorylation | 24531476 |
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RNA A-to-I events for DUSP15 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_918508(31856150, -), ADediting_918509(31856172, -), ADediting_918510(31856188, -), ADediting_918511(31856193, -), ADediting_918512(31856204, -), ADediting_918513(31856205, -), ADediting_918514(31856214, -), ADediting_918515(31856247, -), ADediting_918516(31856279, -), ADediting_918517(31856298, -), ADediting_918518(31856310, -), ADediting_918519(31856311, -), ADediting_918520(31856398, -), ADediting_918521(31857302, -), ADediting_918522(31857500, -), ADediting_918523(31857520, -), ADediting_918524(31857559, -), ADediting_918525(31857565, -), ADediting_918526(31857596, -), ADediting_918527(31857601, -), ADediting_918528(31857604, -), ADediting_918529(31857605, -), ADediting_918530(31857627, -), ADediting_918531(31857629, -), ADediting_918532(31857630, -), ADediting_918533(31857631, -), ADediting_918534(31857639, -), ADediting_918535(31857640, -), ADediting_918536(31857646, -), ADediting_918537(31857664, -), ADediting_918538(31857665, -), ADediting_918539(31857666, -), ADediting_918540(31857670, -), ADediting_918541(31857687, -), ADediting_918542(31857693, -), ADediting_918543(31857694, -), ADediting_918544(31857718, -), ADediting_918545(31857735, -), ADediting_918546(31857738, -), |
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RNA editing positional annotations for DUSP15 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_918508 | chr20_31856150_- | intronic |
| ADediting_918509 | chr20_31856172_- | intronic |
| ADediting_918510 | chr20_31856188_- | intronic |
| ADediting_918511 | chr20_31856193_- | intronic |
| ADediting_918512 | chr20_31856204_- | intronic |
| ADediting_918513 | chr20_31856205_- | intronic |
| ADediting_918514 | chr20_31856214_- | intronic |
| ADediting_918515 | chr20_31856247_- | intronic |
| ADediting_918516 | chr20_31856279_- | intronic |
| ADediting_918517 | chr20_31856298_- | intronic |
| ADediting_918518 | chr20_31856310_- | intronic |
| ADediting_918519 | chr20_31856311_- | intronic |
| ADediting_918520 | chr20_31856398_- | intronic |
| ADediting_918521 | chr20_31857302_- | intronic |
| ADediting_918522 | chr20_31857500_- | intronic |
| ADediting_918523 | chr20_31857520_- | intronic |
| ADediting_918524 | chr20_31857559_- | intronic |
| ADediting_918525 | chr20_31857565_- | intronic |
| ADediting_918526 | chr20_31857596_- | intronic |
| ADediting_918527 | chr20_31857601_- | intronic |
| ADediting_918528 | chr20_31857604_- | intronic |
| ADediting_918529 | chr20_31857605_- | intronic |
| ADediting_918530 | chr20_31857627_- | intronic |
| ADediting_918531 | chr20_31857629_- | intronic |
| ADediting_918532 | chr20_31857630_- | intronic |
| ADediting_918533 | chr20_31857631_- | intronic |
| ADediting_918534 | chr20_31857639_- | intronic |
| ADediting_918535 | chr20_31857640_- | intronic |
| ADediting_918536 | chr20_31857646_- | intronic |
| ADediting_918537 | chr20_31857664_- | intronic |
| ADediting_918538 | chr20_31857665_- | intronic |
| ADediting_918539 | chr20_31857666_- | intronic |
| ADediting_918540 | chr20_31857670_- | intronic |
| ADediting_918541 | chr20_31857687_- | intronic |
| ADediting_918542 | chr20_31857693_- | intronic |
| ADediting_918543 | chr20_31857694_- | intronic |
| ADediting_918544 | chr20_31857718_- | intronic |
| ADediting_918545 | chr20_31857735_- | intronic |
| ADediting_918546 | chr20_31857738_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_918508 | chr20_31856150_- | LINE | L2 | Name=L2c |
| ADediting_918509 | chr20_31856172_- | LINE | L2 | Name=L2c |
| ADediting_918510 | chr20_31856188_- | LINE | L2 | Name=L2c |
| ADediting_918511 | chr20_31856193_- | LINE | L2 | Name=L2c |
| ADediting_918512 | chr20_31856204_- | LINE | L2 | Name=L2c |
| ADediting_918513 | chr20_31856205_- | LINE | L2 | Name=L2c |
| ADediting_918514 | chr20_31856214_- | LINE | L2 | Name=L2c |
| ADediting_918515 | chr20_31856247_- | LINE | L2 | Name=L2c |
| ADediting_918516 | chr20_31856279_- | LINE | L2 | Name=L2c |
| ADediting_918521 | chr20_31857302_- | LINE | L2 | Name=L2c |
| ADediting_918522 | chr20_31857500_- | LINE | L2 | Name=L2c |
| ADediting_918523 | chr20_31857520_- | LINE | L2 | Name=L2c |
| ADediting_918524 | chr20_31857559_- | LINE | L2 | Name=L2c |
| ADediting_918525 | chr20_31857565_- | LINE | L2 | Name=L2c |
| ADediting_918526 | chr20_31857596_- | LINE | L2 | Name=L2c |
| ADediting_918527 | chr20_31857601_- | LINE | L2 | Name=L2c |
| ADediting_918528 | chr20_31857604_- | LINE | L2 | Name=L2c |
| ADediting_918529 | chr20_31857605_- | LINE | L2 | Name=L2c |
| ADediting_918530 | chr20_31857627_- | LINE | L2 | Name=L2c |
| ADediting_918531 | chr20_31857629_- | LINE | L2 | Name=L2c |
| ADediting_918532 | chr20_31857630_- | LINE | L2 | Name=L2c |
| ADediting_918533 | chr20_31857631_- | LINE | L2 | Name=L2c |
| ADediting_918534 | chr20_31857639_- | LINE | L2 | Name=L2c |
| ADediting_918535 | chr20_31857640_- | LINE | L2 | Name=L2c |
| ADediting_918536 | chr20_31857646_- | LINE | L2 | Name=L2c |
| ADediting_918537 | chr20_31857664_- | LINE | L2 | Name=L2c |
| ADediting_918538 | chr20_31857665_- | LINE | L2 | Name=L2c |
| ADediting_918539 | chr20_31857666_- | LINE | L2 | Name=L2c |
| ADediting_918540 | chr20_31857670_- | LINE | L2 | Name=L2c |
| ADediting_918541 | chr20_31857687_- | LINE | L2 | Name=L2c |
| ADediting_918542 | chr20_31857693_- | LINE | L2 | Name=L2c |
| ADediting_918543 | chr20_31857694_- | LINE | L2 | Name=L2c |
| ADediting_918544 | chr20_31857718_- | LINE | L2 | Name=L2c |
| ADediting_918545 | chr20_31857735_- | LINE | L2 | Name=L2c |
| ADediting_918546 | chr20_31857738_- | LINE | L2 | Name=L2c |
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RNA A-to-I editing events in the alternative splicing sites for DUSP15 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for DUSP15 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for DUSP15 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for DUSP15 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_496066 | chr15_66496985_- | ENSG00000149599.15 | ENST00000278979.7 | DUSP15-201 | hsa-miR-4512 | chr20 | 31848176 | 31848183 | 8mer-1a | 31848176 | 31848195 | 151 | -21.61 |
| ADediting_496066 | chr15_66496985_- | ENSG00000149599.15 | ENST00000447647.5 | DUSP15-207 | hsa-miR-4512 | chr20 | 31848176 | 31848183 | 8mer-1a | 31848176 | 31848195 | 151 | -21.61 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_527135 | chr16_24203190_+ | ENSG00000149599.15 | ENST00000339738.9 | DUSP15-202 | hsa-miR-1273h-3p | chr20 | 31861248 | 31861254 | 7mer-m8 | 31861247 | 31861268 | 152 | -24.9 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000149599.15 | ENST00000375966.8 | DUSP15-203 | hsa-miR-1273h-3p | chr20 | 31861248 | 31861254 | 7mer-m8 | 31861247 | 31861268 | 152 | -24.9 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000149599.15 | ENST00000398083.5 | DUSP15-204 | hsa-miR-1273h-3p | chr20 | 31861248 | 31861254 | 7mer-m8 | 31861247 | 31861268 | 152 | -24.9 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000149599.15 | ENST00000398084.6 | DUSP15-205 | hsa-miR-1273h-3p | chr20 | 31861248 | 31861254 | 7mer-m8 | 31861247 | 31861268 | 152 | -24.9 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000149599.15 | ENST00000486996.5 | DUSP15-209 | hsa-miR-1273h-3p | chr20 | 31861248 | 31861254 | 7mer-m8 | 31861247 | 31861268 | 152 | -24.9 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for DUSP15 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for DUSP15 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_918508 | chr20_31856150_- | 0.229860933412942 | 0.0683925637262971 | 0.823987104328328 | 0.0126833248310435 | 8.42324135357693e-09 | 0.319794129537315 |
| DLPFC | ADediting_918509 | chr20_31856172_- | 0.0478052465262054 | 0.112502467603674 | 0.189299583175374 | 0.0747513662455837 | 8.08686320021774e-10 | 0.339844722467722 |
| DLPFC | ADediting_918512 | chr20_31856204_- | 0.132661846052969 | 0.0855926886537708 | 0.804440431998854 | 0.0141193279660997 | 3.45589069237659e-13 | 0.3976527610244 |
| DLPFC | ADediting_918513 | chr20_31856205_- | 0.0362758937291381 | 0.118978983662304 | 0.395797025484912 | 0.0483958022973963 | 1.10737655380549e-15 | 0.434165284132336 |
| DLPFC | ADediting_918514 | chr20_31856214_- | 0.148351379059539 | 0.0822851681175453 | 0.590452049738688 | 0.030683385856571 | 1.06455607235204e-08 | 0.317707989536747 |
| DLPFC | ADediting_918515 | chr20_31856247_- | 0.228429645966988 | 0.0686026326755811 | 0.530786465756848 | 0.0357331657939655 | 5.48366514485077e-08 | 0.30263398285814 |
| DLPFC | ADediting_918517 | chr20_31856298_- | 0.0600834772407732 | 0.106912721191821 | 0.570653265119023 | 0.0323307154152966 | 1.09216422898559e-08 | 0.317478903973171 |
| DLPFC | ADediting_918523 | chr20_31857520_- | 0.054415348541516 | 0.109362242664881 | 0.253189041785015 | 0.0650915704391639 | 2.63656708484824e-08 | 0.309472806449509 |
| DLPFC | ADediting_918524 | chr20_31857559_- | 0.715306375502105 | 0.0207975492717129 | 0.718930723609782 | -0.0205210248905579 | 1.40189852216529e-10 | 0.353952809549054 |
| DLPFC | ADediting_918525 | chr20_31857565_- | 0.286642771047115 | 0.0607066159748398 | 0.782250337256429 | -0.0157604573312325 | 2.66863247090511e-14 | 0.414485072172643 |
| DLPFC | ADediting_918527 | chr20_31857601_- | 0.0398916743235316 | 0.116780860530559 | 0.371235973932718 | -0.0509577640748685 | 6.41090012333146e-21 | 0.498962394857105 |
| DLPFC | ADediting_918531 | chr20_31857629_- | 0.3083559546798 | 0.0580426993622879 | 0.548843411065022 | -0.034177097946416 | 3.78902363303559e-18 | 0.466390556056285 |
| DLPFC | ADediting_918537 | chr20_31857664_- | 0.195866697008025 | 0.0736589141104106 | 0.667059434692405 | -0.0245284063605699 | 2.19496232167766e-15 | 0.430040847025758 |
| DLPFC | ADediting_918541 | chr20_31857687_- | 0.377671221474164 | 0.0502767348101405 | 0.576617195748397 | -0.031831723559484 | 2.54157585512775e-15 | 0.429149611765373 |
| DLPFC | ADediting_918542 | chr20_31857693_- | 0.259406756984386 | 0.0642477653184625 | 0.971656750591857 | 0.00202617826740154 | 2.27166433509307e-15 | 0.429832296717567 |
| DLPFC | ADediting_918543 | chr20_31857694_- | 0.151590572356851 | 0.0816358801336498 | 0.601312497159326 | 0.0297905602502406 | 2.75139804884047e-12 | 0.383282723471843 |
| DLPFC | ADediting_918544 | chr20_31857718_- | 0.0575369881830216 | 0.107988439192867 | 0.475401919418156 | 0.0406839938565012 | 3.89650129044946e-10 | 0.345808720231097 |
| DLPFC | ADediting_918545 | chr20_31857735_- | 0.147926708976978 | 0.0823710882257504 | 0.634529816575155 | -0.0271032101628896 | 1.79040822303103e-16 | 0.444883804655683 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 0.0002105648750135 | 0.209001310471498 | 0.0010557818420663 | 0.18515720071417 | 2.66097797192437e-33 | 0.612436738840177 |
| AC | 3.93751418860424e-29 | 0.630665265571034 | 7.09461833825711e-14 | 0.450132016058544 | 4.00635834491211e-27 | 0.612379817887442 |
| PCC | 0.000162889493558685 | 0.269530058951201 | 0.000598748332434882 | 0.246128048779171 | 4.31820847581411e-06 | 0.325548820759247 |
| CER | 0.00400371158079544 | -0.233669799678724 | 6.63351029381605e-06 | -0.358536102205828 | 0.500096255942179 | 0.055481187365235 |
| TCX | 0.548108250107396 | 0.0494220195269058 | 0.0254691120153083 | -0.18241525490236 | 1.48335117342455e-05 | 0.345570329786858 |
| FP | 1.34220361175877e-05 | 0.319916875306223 | 0.0039511969210692 | 0.21500009477343 | 0.00799604994717207 | 0.198213629937729 |
| IFG | 0.0127177028285971 | 0.490876866332259 | 0.169624380309202 | 0.283522383475485 | 0.0125167992813564 | 0.491842857254501 |
| STG | 0.00178887971092543 | 0.335846858862138 | 0.240270208854381 | 0.12952814550463 | 0.00266994127868497 | 0.323676222122503 |
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Relation with AD stages for DUSP15 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for DUSP15 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DUSP15 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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