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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for OSCP1 |
 Gene summary |
| Gene information | Gene symbol | OSCP1 | Gene ID | 127700 |
| Gene name | organic solute carrier partner 1 | |
| Synonyms | C1orf102|NOR1 | |
| Cytomap | 1p34.3 | |
| Type of gene | protein-coding | |
| Description | protein OSCP1organic solute carrier protein 1organic solute transport protein 1oxidored nitro domain containing proteinoxidored-nitro domain-containing protein 1 | |
| Modification date | 20200313 | |
| UniProtAcc | Q8WVF1, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for OSCP1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_106712(36416334, -), ADediting_106713(36416396, -), ADediting_106714(36416400, -), ADediting_106715(36416410, -), ADediting_106716(36416423, -), ADediting_106717(36416444, -), ADediting_106718(36416498, -), ADediting_106719(36416503, -), ADediting_106720(36416508, -), ADediting_106721(36417182, -), ADediting_106722(36417207, -), ADediting_106723(36417211, -), ADediting_106724(36417217, -), ADediting_106725(36417227, -), ADediting_106726(36417258, -), ADediting_106727(36417277, -), ADediting_106728(36417285, -), ADediting_106729(36417306, -), ADediting_106730(36417307, -), ADediting_106731(36417314, -), ADediting_106732(36417317, -), ADediting_106733(36417355, -), ADediting_106734(36417369, -), ADediting_106735(36418691, -), ADediting_106736(36418828, -), ADediting_106737(36418842, -), ADediting_106738(36418859, -), ADediting_106739(36418876, -), ADediting_106740(36423612, -), ADediting_106741(36424062, -), ADediting_106742(36424073, -), ADediting_106743(36424213, -), ADediting_106744(36424232, -), ADediting_106745(36425664, -), ADediting_106746(36427229, -), ADediting_106747(36427371, -), ADediting_106748(36427414, -), ADediting_106749(36427996, -), ADediting_106750(36428008, -), ADediting_106751(36428022, -), ADediting_106752(36428862, -), ADediting_106753(36428882, -), ADediting_106754(36429048, -), ADediting_106755(36429126, -), ADediting_106756(36429287, -), ADediting_106757(36429653, -), ADediting_106758(36429655, -), ADediting_106759(36429896, -), ADediting_106760(36429907, -), ADediting_106761(36430154, -), ADediting_106762(36430206, -), ADediting_106763(36430519, -), ADediting_106764(36437746, -), ADediting_106765(36437765, -), ADediting_1519777(36417275, -), ADediting_1519778(36418713, -), |
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RNA editing positional annotations for OSCP1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_106712 | chr1_36416334_- | intronic |
| ADediting_106713 | chr1_36416396_- | intronic |
| ADediting_106714 | chr1_36416400_- | intronic |
| ADediting_106715 | chr1_36416410_- | intronic |
| ADediting_106716 | chr1_36416423_- | intronic |
| ADediting_106717 | chr1_36416444_- | intronic |
| ADediting_106718 | chr1_36416498_- | intronic |
| ADediting_106719 | chr1_36416503_- | intronic |
| ADediting_106720 | chr1_36416508_- | intronic |
| ADediting_106721 | chr1_36417182_- | intronic |
| ADediting_106722 | chr1_36417207_- | intronic |
| ADediting_106723 | chr1_36417211_- | intronic |
| ADediting_106724 | chr1_36417217_- | intronic |
| ADediting_106725 | chr1_36417227_- | intronic |
| ADediting_106726 | chr1_36417258_- | intronic |
| ADediting_106727 | chr1_36417277_- | intronic |
| ADediting_106728 | chr1_36417285_- | intronic |
| ADediting_106729 | chr1_36417306_- | intronic |
| ADediting_106730 | chr1_36417307_- | intronic |
| ADediting_106731 | chr1_36417314_- | intronic |
| ADediting_106732 | chr1_36417317_- | intronic |
| ADediting_106733 | chr1_36417355_- | intronic |
| ADediting_106734 | chr1_36417369_- | intronic |
| ADediting_106735 | chr1_36418691_- | intronic |
| ADediting_106736 | chr1_36418828_- | intronic |
| ADediting_106737 | chr1_36418842_- | intronic |
| ADediting_106738 | chr1_36418859_- | intronic |
| ADediting_106739 | chr1_36418876_- | intronic |
| ADediting_106740 | chr1_36423612_- | intronic |
| ADediting_106741 | chr1_36424062_- | intronic |
| ADediting_106742 | chr1_36424073_- | intronic |
| ADediting_106743 | chr1_36424213_- | intronic |
| ADediting_106744 | chr1_36424232_- | intronic |
| ADediting_106745 | chr1_36425664_- | intronic |
| ADediting_106746 | chr1_36427229_- | intronic |
| ADediting_106747 | chr1_36427371_- | intronic |
| ADediting_106748 | chr1_36427414_- | intronic |
| ADediting_106749 | chr1_36427996_- | intronic |
| ADediting_106750 | chr1_36428008_- | intronic |
| ADediting_106751 | chr1_36428022_- | intronic |
| ADediting_106752 | chr1_36428862_- | intronic |
| ADediting_106753 | chr1_36428882_- | intronic |
| ADediting_106754 | chr1_36429048_- | intronic |
| ADediting_106755 | chr1_36429126_- | intronic |
| ADediting_106756 | chr1_36429287_- | intronic |
| ADediting_106757 | chr1_36429653_- | intronic |
| ADediting_106758 | chr1_36429655_- | intronic |
| ADediting_106759 | chr1_36429896_- | intronic |
| ADediting_106760 | chr1_36429907_- | intronic |
| ADediting_106761 | chr1_36430154_- | intronic |
| ADediting_106762 | chr1_36430206_- | intronic |
| ADediting_106763 | chr1_36430519_- | intronic |
| ADediting_106764 | chr1_36437746_- | intronic |
| ADediting_106765 | chr1_36437765_- | intronic |
| ADediting_1519777 | chr1_36417275_- | intronic |
| ADediting_1519778 | chr1_36418713_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_106712 | chr1_36416334_- | SINE | Alu | Name=AluSp |
| ADediting_106713 | chr1_36416396_- | SINE | Alu | Name=AluSp |
| ADediting_106714 | chr1_36416400_- | SINE | Alu | Name=AluSp |
| ADediting_106715 | chr1_36416410_- | SINE | Alu | Name=AluSp |
| ADediting_106716 | chr1_36416423_- | SINE | Alu | Name=AluSp |
| ADediting_106717 | chr1_36416444_- | SINE | Alu | Name=AluSp |
| ADediting_106718 | chr1_36416498_- | SINE | Alu | Name=AluSp |
| ADediting_106719 | chr1_36416503_- | SINE | Alu | Name=AluSp |
| ADediting_106720 | chr1_36416508_- | SINE | Alu | Name=AluSp |
| ADediting_106721 | chr1_36417182_- | SINE | Alu | Name=AluYm1 |
| ADediting_106722 | chr1_36417207_- | SINE | Alu | Name=AluYm1 |
| ADediting_106723 | chr1_36417211_- | SINE | Alu | Name=AluYm1 |
| ADediting_106724 | chr1_36417217_- | SINE | Alu | Name=AluYm1 |
| ADediting_106725 | chr1_36417227_- | SINE | Alu | Name=AluYm1 |
| ADediting_106726 | chr1_36417258_- | SINE | Alu | Name=AluYm1 |
| ADediting_106727 | chr1_36417277_- | SINE | Alu | Name=AluYm1 |
| ADediting_106728 | chr1_36417285_- | SINE | Alu | Name=AluYm1 |
| ADediting_106729 | chr1_36417306_- | SINE | Alu | Name=AluYm1 |
| ADediting_106730 | chr1_36417307_- | SINE | Alu | Name=AluYm1 |
| ADediting_106731 | chr1_36417314_- | SINE | Alu | Name=AluYm1 |
| ADediting_106732 | chr1_36417317_- | SINE | Alu | Name=AluYm1 |
| ADediting_106733 | chr1_36417355_- | SINE | Alu | Name=AluYm1 |
| ADediting_106734 | chr1_36417369_- | SINE | Alu | Name=AluYm1 |
| ADediting_106735 | chr1_36418691_- | SINE | Alu | Name=AluSx1 |
| ADediting_106736 | chr1_36418828_- | SINE | Alu | Name=AluSx1 |
| ADediting_106737 | chr1_36418842_- | SINE | Alu | Name=AluSx1 |
| ADediting_106738 | chr1_36418859_- | SINE | Alu | Name=AluSx1 |
| ADediting_106739 | chr1_36418876_- | SINE | Alu | Name=AluSx1 |
| ADediting_106740 | chr1_36423612_- | SINE | Alu | Name=AluSc8 |
| ADediting_106741 | chr1_36424062_- | SINE | Alu | Name=AluSz |
| ADediting_106742 | chr1_36424073_- | SINE | Alu | Name=AluSz |
| ADediting_106743 | chr1_36424213_- | SINE | Alu | Name=AluSz |
| ADediting_106744 | chr1_36424232_- | SINE | Alu | Name=AluSz |
| ADediting_106745 | chr1_36425664_- | SINE | Alu | Name=AluSx3 |
| ADediting_106746 | chr1_36427229_- | SINE | Alu | Name=AluSg4 |
| ADediting_106747 | chr1_36427371_- | SINE | Alu | Name=AluSc5 |
| ADediting_106748 | chr1_36427414_- | SINE | Alu | Name=AluSc5 |
| ADediting_106749 | chr1_36427996_- | SINE | Alu | Name=AluSx |
| ADediting_106750 | chr1_36428008_- | SINE | Alu | Name=AluSx |
| ADediting_106751 | chr1_36428022_- | SINE | Alu | Name=AluSx |
| ADediting_106752 | chr1_36428862_- | SINE | Alu | Name=AluSx1 |
| ADediting_106753 | chr1_36428882_- | SINE | Alu | Name=AluSx1 |
| ADediting_106754 | chr1_36429048_- | SINE | Alu | Name=FLAM_A |
| ADediting_106755 | chr1_36429126_- | SINE | Alu | Name=AluJo |
| ADediting_106756 | chr1_36429287_- | SINE | Alu | Name=AluJo |
| ADediting_106757 | chr1_36429653_- | SINE | Alu | Name=AluJb |
| ADediting_106758 | chr1_36429655_- | SINE | Alu | Name=AluJb |
| ADediting_106759 | chr1_36429896_- | SINE | Alu | Name=AluSg4 |
| ADediting_106760 | chr1_36429907_- | SINE | Alu | Name=AluSg4 |
| ADediting_106761 | chr1_36430154_- | SINE | Alu | Name=AluJb |
| ADediting_106762 | chr1_36430206_- | SINE | Alu | Name=AluJb |
| ADediting_106763 | chr1_36430519_- | SINE | Alu | Name=FLAM_C |
| ADediting_106764 | chr1_36437746_- | SINE | Alu | Name=AluSz |
| ADediting_106765 | chr1_36437765_- | SINE | Alu | Name=AluSz |
| ADediting_1519777 | chr1_36417275_- | SINE | Alu | Name=AluYm1 |
| ADediting_1519778 | chr1_36418713_- | SINE | Alu | Name=AluSx1 |
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RNA A-to-I editing events in the alternative splicing sites for OSCP1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for OSCP1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for OSCP1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for OSCP1 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000116885.18 | ENST00000468441.5 | OSCP1-206 | hsa-miR-589-3p | chr1 | 36415969 | 36415976 | 8mer-1a | 36415969 | 36415990 | 147 | -15.74 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000116885.18 | ENST00000445843.7 | OSCP1-205 | hsa-miR-589-3p | chr1 | 36418130 | 36418137 | 8mer-1a | 36418130 | 36418154 | 143 | -17.28 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for OSCP1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for OSCP1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_106725 | chr1_36417227_- | 0.0139040418969789 | 0.200470245089463 | 6.14851485734817e-05 | 0.321150148209888 | 0.106413085399448 | 0.132352193992493 |
| TCX | ADediting_106733 | chr1_36417355_- | 0.00808336943524749 | 0.215510194628192 | 1.64302997116565e-05 | 0.343881416420287 | 0.829498058806882 | -0.0177298119117606 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 2.94448506693444e-46 | 0.696211445014242 | 2.47783176154394e-77 | 0.822108424433072 | 0.4348551342231 | 0.044510561795602 |
| AC | 3.67253958158795e-104 | 0.921968951705837 | 1.90000070930584e-69 | 0.845259062638899 | 1.01834432136659e-06 | 0.303352794224058 |
| PCC | 1.26550594908881e-52 | 0.842325684630055 | 1.62518686479259e-56 | 0.857752977346109 | 0.0962090754570159 | 0.120719666010468 |
| CER | 7.814681213124e-24 | 0.704851385304432 | 1.3722257619995e-15 | 0.592568772985156 | 0.00372126108533586 | 0.235484919470565 |
| TCX | 5.56279463689806e-24 | 0.706474545014159 | 4.4647974522821e-27 | 0.738131782110941 | 0.019958375015638 | -0.189865897598924 |
| FP | 9.72554197941731e-23 | 0.649896622041875 | 3.25745946275451e-30 | 0.724162829137623 | 0.526554117362108 | 0.0477754389791646 |
| IFG | 2.89142576672163e-06 | 0.788175887387859 | 0.000473318250905321 | 0.64700559969112 | 0.639508374165201 | -0.0984913159272611 |
| PG | 1.9188530224239e-50 | 0.838694154506785 | 2.07153405643866e-34 | 0.746671881739792 | 0.23770449969922 | -0.0869985679221133 |
| STG | 6.4789670733778e-20 | 0.800434476603966 | 4.93943609920763e-18 | 0.775200511667622 | 0.629110043066172 | 0.0534607596343961 |
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Relation with AD stages for OSCP1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 0.000805343435105343 | 0.317744067023844 |
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RelatedDrugs for OSCP1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OSCP1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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