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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for ZNF816 |
 Gene summary |
| Gene information | Gene symbol | ZNF816 | Gene ID | 125893 |
| Gene name | zinc finger protein 816 | |
| Synonyms | ZNF816A | |
| Cytomap | 19q13.41 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 816zinc finger protein 816A | |
| Modification date | 20200313 | |
| UniProtAcc | Q0VGE8, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for ZNF816 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_780552(52951776, -), ADediting_780553(52951786, -), ADediting_780554(52951812, -), ADediting_780555(52951815, -), ADediting_780556(52952134, -), ADediting_780557(52952151, -), ADediting_780558(52952152, -), ADediting_780559(52952176, -), ADediting_780560(52952287, -), ADediting_780561(52952293, -), ADediting_1558587(52952098, -), ADediting_1558588(52952139, -), ADediting_1558589(52952241, -), ADediting_1558590(52952283, -), ADediting_1558591(52952284, -), |
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RNA editing positional annotations for ZNF816 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_780552 | chr19_52951776_- | UTR3 |
| ADediting_780553 | chr19_52951786_- | UTR3 |
| ADediting_780554 | chr19_52951812_- | UTR3 |
| ADediting_780555 | chr19_52951815_- | UTR3 |
| ADediting_780556 | chr19_52952134_- | intronic |
| ADediting_780557 | chr19_52952151_- | intronic |
| ADediting_780558 | chr19_52952152_- | intronic |
| ADediting_780559 | chr19_52952176_- | intronic |
| ADediting_780560 | chr19_52952287_- | intronic |
| ADediting_780561 | chr19_52952293_- | intronic |
| ADediting_1558587 | chr19_52952098_- | intronic |
| ADediting_1558588 | chr19_52952139_- | intronic |
| ADediting_1558589 | chr19_52952241_- | intronic |
| ADediting_1558590 | chr19_52952283_- | intronic |
| ADediting_1558591 | chr19_52952284_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_780552 | chr19_52951776_- | SINE | Alu | Name=AluSq2 |
| ADediting_780553 | chr19_52951786_- | SINE | Alu | Name=AluSq2 |
| ADediting_780554 | chr19_52951812_- | SINE | Alu | Name=AluSq2 |
| ADediting_780555 | chr19_52951815_- | SINE | Alu | Name=AluSq2 |
| ADediting_780556 | chr19_52952134_- | SINE | Alu | Name=AluSz6 |
| ADediting_780557 | chr19_52952151_- | SINE | Alu | Name=AluSz6 |
| ADediting_780558 | chr19_52952152_- | SINE | Alu | Name=AluSz6 |
| ADediting_780559 | chr19_52952176_- | SINE | Alu | Name=AluSz6 |
| ADediting_780560 | chr19_52952287_- | SINE | Alu | Name=AluSz6 |
| ADediting_780561 | chr19_52952293_- | SINE | Alu | Name=AluSz6 |
| ADediting_1558587 | chr19_52952098_- | SINE | Alu | Name=AluSz6 |
| ADediting_1558588 | chr19_52952139_- | SINE | Alu | Name=AluSz6 |
| ADediting_1558589 | chr19_52952241_- | SINE | Alu | Name=AluSz6 |
| ADediting_1558590 | chr19_52952283_- | SINE | Alu | Name=AluSz6 |
| ADediting_1558591 | chr19_52952284_- | SINE | Alu | Name=AluSz6 |
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RNA A-to-I editing events in the alternative splicing sites for ZNF816 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ZNF816 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for ZNF816 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for ZNF816 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_780553 | chr19_52951786_- | ENSG00000180257.13 | ENST00000438970.6 | ZNF816-205 | hsa-miR-4691-3p | chr19 | 52951782 | 52951788 | 7mer-m8 | 52951781 | 52951808 | 151 | -29.72 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_780553 | chr19_52951786_- | ENSG00000180257.13 | ENST00000438970.6 | ZNF816-205 | hsa-miR-5690 | chr19 | 52951782 | 52951788 | 7mer-m8 | 52951781 | 52951801 | 145 | -17.72 |
| ADediting_780554 | chr19_52951812_- | ENSG00000180257.13 | ENST00000438970.6 | ZNF816-205 | hsa-miR-219b-3p | chr19 | 52951808 | 52951814 | 7mer-m8 | 52951807 | 52951829 | 149 | -15.83 |
| ADediting_780554 | chr19_52951812_- | ENSG00000180257.13 | ENST00000438970.6 | ZNF816-205 | hsa-miR-302f | chr19 | 52951809 | 52951815 | 7mer-m8 | 52951808 | 52951824 | 145 | -7.88 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000180257.13 | ENST00000357666.8 | ZNF816-203 | hsa-miR-337-3p | chr19 | 52949591 | 52949597 | 7mer-m8 | 52949590 | 52949611 | 160 | -21.58 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000180257.13 | ENST00000391786.6 | ZNF816-204 | hsa-miR-337-3p | chr19 | 52951529 | 52951535 | 7mer-m8 | 52951528 | 52951552 | 147 | -20.99 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000180257.13 | ENST00000444460.6 | ZNF816-206 | hsa-miR-337-3p | chr19 | 52949591 | 52949597 | 7mer-m8 | 52949590 | 52949611 | 160 | -21.58 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000180257.13 | ENST00000357666.8 | ZNF816-203 | hsa-miR-4775 | chr19 | 52949390 | 52949396 | 7mer-m8 | 52949389 | 52949411 | 165 | -12.59 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000180257.13 | ENST00000391786.6 | ZNF816-204 | hsa-miR-4775 | chr19 | 52951377 | 52951384 | 8mer-1a | 52951377 | 52951398 | 155 | -12.41 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for ZNF816 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000438970.6 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_780552 | ENST00000438970.6 | chr19_52951776_- | 466 | -176.90 | -174.10 | -176.70 |
| ADediting_780553 | ENST00000438970.6 | chr19_52951786_- | 456 | -175.20 | -174.10 | -176.70 |
| ADediting_780554 | ENST00000438970.6 | chr19_52951812_- | 430 | -173.80 | -174.10 | -176.70 |
| ADediting_780555 | ENST00000438970.6 | chr19_52951815_- | 427 | -174.10 | -174.10 | -176.70 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for ZNF816 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1558591 | chr19_52952284_- | 2.93547216205094e-06 | 0.371117419541609 | 3.3588044861324e-07 | 0.40221958056123 | 0.421259294384768 | 0.0661471843530246 |
| CER | ADediting_780553 | chr19_52951786_- | 0.000152210329015787 | 0.304417004906756 | 7.53318856509925e-05 | 0.317486086996654 | 0.00774267131875733 | 0.216663744136687 |
| CER | ADediting_780554 | chr19_52951812_- | 0.0174589757025722 | 0.193849815269874 | 0.000125685735486302 | 0.308035548284714 | 0.151402535985979 | 0.117711272766114 |
| CER | ADediting_780556 | chr19_52952134_- | 5.86181410743952e-05 | 0.322004775742602 | 2.29177246889333e-08 | 0.436812965686275 | 0.577596273252909 | 0.0458301196858065 |
| CER | ADediting_780557 | chr19_52952151_- | 7.09851507451332e-07 | 0.391840197676149 | 5.63163245748408e-09 | 0.453465425160139 | 0.675652421658014 | 0.0344404417804622 |
| CER | ADediting_780558 | chr19_52952152_- | 4.02387277697933e-05 | 0.328650141384421 | 5.36041167912302e-07 | 0.395777214621961 | 0.767010990285216 | 0.0243921756676917 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 5.5017838060139e-23 | 0.521164321321288 | 1.36832698458395e-10 | 0.354143113356429 | 2.17492207018283e-09 | 0.331555836526464 |
| AC | 1.89149976205204e-45 | 0.744709852515602 | 2.55711184696004e-25 | 0.594856283298921 | 3.6677637728023e-22 | 0.561390717906009 |
| PCC | 7.45503624849693e-12 | 0.469333849956219 | 1.52906139837738e-08 | 0.395220951884816 | 1.33614387190734e-10 | 0.443346279745299 |
| CER | 1.39944369274886e-30 | 0.769175722815812 | 1.76208562187301e-22 | 0.689441712392825 | 0.0319491309595553 | 0.175250579755322 |
| TCX | 2.17760153209834e-09 | 0.464252613550694 | 0.0990016476013835 | 0.135210306787979 | 3.517340742193e-10 | 0.483956583305898 |
| FP | 3.57447509856886e-11 | 0.470111459612186 | 3.31332127377714e-12 | 0.491338754973275 | 2.12068872943301e-09 | 0.429879189613052 |
| IFG | 0.041117162617402 | 0.411248789446013 | 0.247267260842615 | 0.240294524560817 | 0.0726388002317644 | 0.365198203291695 |
| PG | 1.49906788975107e-23 | 0.648226381204152 | 5.43835522902272e-16 | 0.548332493354443 | 0.0804713408706537 | 0.128500848903284 |
| STG | 0.00442795404305421 | 0.307562250787121 | 0.00167380714130185 | 0.337821108609825 | 3.46565208777494e-05 | 0.435521729351025 |
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Relation with AD stages for ZNF816 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 0.000158254710029567 | 0.355690052176831 |
| TCX | 8.24436895623319e-09 | 0.523923308219554 |
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RelatedDrugs for ZNF816 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF816 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| ZNF816 | C0030246 | Pustulosis of Palms and Soles | 2 | CTD_human |
| ZNF816 | C0033860 | Psoriasis | 2 | CTD_human |
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