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	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene

Gene summary for CLN3

Gene summary

Gene information	Gene symbol	CLN3
	Gene ID	1201
	Gene name	CLN3 lysosomal/endosomal transmembrane protein, battenin
	Synonyms	BTN1|BTS|JNCL
	Cytomap	16p12.1
	Type of gene	protein-coding
	Description	batteninCLN3, batteninbatten disease proteinceroid-lipofuscinosis, neuronal 3
	Modification date	20200328
	UniProtAcc	Q13286,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CLN3	GO:0015809	arginine transport	16251196
CLN3	GO:0035752	lysosomal lumen pH elevation	10924275
CLN3	GO:0042987	amyloid precursor protein catabolic process	10924275

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RNA A-to-I events for CLN3

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_532026(28474168, -), ADediting_532027(28474185, -), ADediting_532028(28474338, -), ADediting_532029(28474360, -), ADediting_532030(28474365, -), ADediting_532031(28474377, -), ADediting_532032(28474868, -), ADediting_532033(28474877, -), ADediting_532034(28474881, -), ADediting_532035(28474885, -), ADediting_532036(28474898, -), ADediting_532037(28474911, -), ADediting_532038(28474937, -), ADediting_532039(28474990, -), ADediting_532040(28474993, -), ADediting_532041(28474999, -), ADediting_532042(28475005, -), ADediting_532043(28475006, -), ADediting_532044(28475032, -), ADediting_532045(28475053, -), ADediting_532046(28475057, -), ADediting_532047(28475095, -), ADediting_532048(28475110, -), ADediting_532049(28475133, -), ADediting_532050(28475134, -), ADediting_532051(28475167, -), ADediting_532052(28475168, -), ADediting_532053(28475181, -), ADediting_532054(28475182, -), ADediting_532055(28475193, -), ADediting_532056(28475214, -), ADediting_532057(28475946, -), ADediting_532058(28475951, -), ADediting_532059(28475978, -), ADediting_532060(28475982, -), ADediting_532061(28475994, -), ADediting_532062(28475995, -), ADediting_532063(28476007, -), ADediting_532064(28476014, -), ADediting_532065(28476024, -), ADediting_532066(28476046, -), ADediting_532067(28476050, -), ADediting_532068(28476053, -), ADediting_532069(28476054, -), ADediting_532070(28476055, -), ADediting_532071(28476064, -), ADediting_532072(28476069, -), ADediting_532073(28476081, -), ADediting_532074(28476090, -), ADediting_532075(28476114, -), ADediting_532076(28476119, -), ADediting_532077(28476151, -), ADediting_532078(28476159, -), ADediting_532079(28476160, -), ADediting_532080(28476166, -), ADediting_532081(28476283, -), ADediting_532082(28476286, -), ADediting_532083(28476289, -), ADediting_532084(28476298, -), ADediting_532085(28476301, -), ADediting_532086(28476302, -), ADediting_532087(28476325, -), ADediting_532088(28476355, -), ADediting_532089(28476421, -), ADediting_532090(28476434, -), ADediting_532091(28476451, -), ADediting_532092(28476453, -), ADediting_532093(28476462, -), ADediting_532094(28476463, -), ADediting_532095(28476470, -), ADediting_532096(28476510, -), ADediting_532097(28476524, -), ADediting_532098(28476546, -), ADediting_532099(28476880, -), ADediting_532100(28476885, -), ADediting_532101(28476892, -), ADediting_532102(28476907, -), ADediting_532103(28476920, -), ADediting_532104(28476932, -), ADediting_532105(28476934, -), ADediting_532106(28476974, -), ADediting_532107(28476980, -), ADediting_532108(28476982, -), ADediting_532109(28476989, -), ADediting_532110(28477037, -), ADediting_532111(28477050, -), ADediting_532112(28477054, -), ADediting_532113(28477055, -), ADediting_532114(28477067, -), ADediting_532115(28477079, -), ADediting_532116(28477097, -), ADediting_532117(28477114, -), ADediting_532118(28477122, -), ADediting_532119(28477128, -), ADediting_532120(28477130, -), ADediting_532121(28478039, -), ADediting_532122(28478053, -), ADediting_532123(28478054, -), ADediting_532124(28478063, -), ADediting_532125(28478068, -), ADediting_532126(28478081, -), ADediting_532127(28478147, -), ADediting_532128(28478193, -), ADediting_532129(28478197, -), ADediting_532130(28478205, -), ADediting_532131(28478222, -), ADediting_532132(28478229, -), ADediting_532133(28478398, -), ADediting_532134(28478399, -), ADediting_532135(28478433, -), ADediting_532136(28478504, -), ADediting_532137(28479008, -), ADediting_532138(28479009, -), ADediting_532139(28479011, -), ADediting_532140(28479403, -), ADediting_532141(28479423, -), ADediting_532142(28479465, -), ADediting_532143(28479475, -), ADediting_532144(28479505, -), ADediting_532145(28479551, -), ADediting_532146(28479556, -), ADediting_532147(28479566, -), ADediting_532148(28479582, -), ADediting_532149(28479588, -), ADediting_532150(28479657, -), ADediting_532151(28479669, -), ADediting_532152(28479686, -), ADediting_532153(28479693, -), ADediting_532154(28479722, -), ADediting_532155(28479735, -), ADediting_532156(28480026, -), ADediting_532157(28480027, -), ADediting_532158(28480053, -), ADediting_532159(28480058, -), ADediting_532160(28480089, -), ADediting_532161(28480098, -), ADediting_532162(28480099, -), ADediting_532163(28480158, -), ADediting_532164(28480253, -), ADediting_532165(28480285, -), ADediting_532166(28480305, -), ADediting_532167(28480320, -), ADediting_532168(28480349, -), ADediting_532169(28480461, -), ADediting_532170(28480497, -), ADediting_532171(28480506, -), ADediting_532172(28480529, -), ADediting_532173(28480565, -), ADediting_532174(28480569, -), ADediting_532175(28480578, -), ADediting_532176(28480600, -), ADediting_532177(28480653, -), ADediting_532178(28480657, -), ADediting_532179(28480658, -), ADediting_532180(28481070, -), ADediting_532181(28481080, -), ADediting_532182(28481150, -), ADediting_532183(28481154, -), ADediting_532184(28481184, -), ADediting_532185(28481194, -), ADediting_532186(28481203, -), ADediting_532187(28481213, -), ADediting_532188(28481231, -), ADediting_532189(28481238, -), ADediting_532190(28481248, -), ADediting_532191(28481254, -), ADediting_532192(28481256, -), ADediting_532193(28481264, -), ADediting_532194(28481274, -), ADediting_532195(28481319, -), ADediting_532196(28481320, -), ADediting_532197(28481333, -), ADediting_532198(28481347, -), ADediting_532199(28481362, -), ADediting_532200(28481373, -), ADediting_532201(28481374, -), ADediting_532202(28481748, -), ADediting_532203(28481757, -), ADediting_532204(28481775, -), ADediting_532205(28481802, -), ADediting_532206(28481824, -), ADediting_532207(28481839, -), ADediting_532208(28481865, -), ADediting_532209(28481875, -), ADediting_532210(28481904, -), ADediting_532211(28481924, -), ADediting_532212(28481940, -), ADediting_532213(28481946, -), ADediting_532214(28482841, -), ADediting_532215(28482844, -), ADediting_532216(28482912, -), ADediting_532217(28482982, -), ADediting_532218(28483004, -), ADediting_532219(28483448, -), ADediting_532220(28483468, -), ADediting_532221(28483501, -), ADediting_532222(28484417, -), ADediting_532223(28484477, -), ADediting_532224(28484487, -), ADediting_532225(28484584, -), ADediting_532226(28485038, -), ADediting_532227(28485042, -), ADediting_532228(28485043, -), ADediting_532229(28485083, -), ADediting_532230(28485124, -), ADediting_532231(28485127, -), ADediting_532232(28485138, -), ADediting_532233(28485146, -), ADediting_532234(28485177, -), ADediting_532235(28485210, -), ADediting_532236(28485215, -), ADediting_532237(28485216, -), ADediting_532238(28485250, -), ADediting_532239(28485251, -), ADediting_532240(28485312, -), ADediting_532241(28485316, -), ADediting_532242(28485321, -), ADediting_532243(28485410, -), ADediting_532244(28485412, -), ADediting_532245(28485446, -), ADediting_532246(28485456, -), ADediting_532247(28485468, -), ADediting_532248(28485485, -), ADediting_532249(28485516, -), ADediting_532250(28486083, -), ADediting_532251(28486094, -), ADediting_532252(28486113, -), ADediting_532253(28486114, -), ADediting_532254(28486122, -), ADediting_532255(28486162, -), ADediting_532256(28486191, -), ADediting_532257(28486224, -), ADediting_532258(28486225, -), ADediting_532259(28486234, -), ADediting_532260(28486242, -), ADediting_532261(28488977, -), ADediting_532262(28489013, -), ADediting_532263(28489040, -), ADediting_1541819(28474413, -), ADediting_1541820(28474899, -), ADediting_1541821(28474930, -), ADediting_1541822(28475102, -), ADediting_1541823(28476060, -), ADediting_1541824(28476063, -), ADediting_1541825(28476351, -), ADediting_1541826(28476402, -), ADediting_1541827(28476540, -), ADediting_1541828(28476988, -), ADediting_1541829(28478359, -), ADediting_1541830(28478450, -), ADediting_1541831(28478516, -), ADediting_1541832(28478529, -), ADediting_1541833(28479452, -), ADediting_1541834(28480018, -), ADediting_1541835(28480023, -), ADediting_1541836(28480044, -), ADediting_1541837(28480184, -), ADediting_1541838(28480326, -), ADediting_1541839(28480448, -), ADediting_1541840(28480453, -), ADediting_1541841(28480458, -), ADediting_1541842(28481270, -), ADediting_1541843(28481302, -), ADediting_1541844(28481365, -), ADediting_1541845(28481821, -), ADediting_1541846(28481838, -), ADediting_1541847(28484609, -),

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RNA editing positional annotations for CLN3 using Annovar

Protein coding RNA editing(s).

ADeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
ADediting_532026	chr16_28474168_-	nonsynonymous SNV	ENST00000637100.1	c.A1100G	p.Q367R	.	.	.
ADediting_532027	chr16_28474185_-	synonymous SNV	ENST00000637100.1	c.A1083G	p.Q361Q	.	.	.
ADediting_532155	chr16_28479735_-	nonsynonymous SNV	ENST00000569030.5	c.A757G	p.M253V	.	.	.
ADediting_532155	chr16_28479735_-	nonsynonymous SNV	ENST00000637184.1	c.A1087G	p.M363V	.	.	.

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_532026	chr16_28474168_-	exonic
ADediting_532027	chr16_28474185_-	exonic
ADediting_532028	chr16_28474338_-	intronic
ADediting_532029	chr16_28474360_-	intronic
ADediting_532030	chr16_28474365_-	intronic
ADediting_532031	chr16_28474377_-	intronic
ADediting_532032	chr16_28474868_-	intronic
ADediting_532033	chr16_28474877_-	intronic
ADediting_532034	chr16_28474881_-	intronic
ADediting_532035	chr16_28474885_-	intronic
ADediting_532036	chr16_28474898_-	intronic
ADediting_532037	chr16_28474911_-	intronic
ADediting_532038	chr16_28474937_-	intronic
ADediting_532039	chr16_28474990_-	intronic
ADediting_532040	chr16_28474993_-	intronic
ADediting_532041	chr16_28474999_-	intronic
ADediting_532042	chr16_28475005_-	intronic
ADediting_532043	chr16_28475006_-	intronic
ADediting_532044	chr16_28475032_-	intronic
ADediting_532045	chr16_28475053_-	intronic
ADediting_532046	chr16_28475057_-	intronic
ADediting_532047	chr16_28475095_-	intronic
ADediting_532048	chr16_28475110_-	intronic
ADediting_532049	chr16_28475133_-	intronic
ADediting_532050	chr16_28475134_-	intronic
ADediting_532051	chr16_28475167_-	intronic
ADediting_532052	chr16_28475168_-	intronic
ADediting_532053	chr16_28475181_-	intronic
ADediting_532054	chr16_28475182_-	intronic
ADediting_532055	chr16_28475193_-	intronic
ADediting_532056	chr16_28475214_-	intronic
ADediting_532057	chr16_28475946_-	UTR3
ADediting_532058	chr16_28475951_-	UTR3
ADediting_532059	chr16_28475978_-	UTR3
ADediting_532060	chr16_28475982_-	UTR3
ADediting_532061	chr16_28475994_-	UTR3
ADediting_532062	chr16_28475995_-	UTR3
ADediting_532063	chr16_28476007_-	UTR3
ADediting_532064	chr16_28476014_-	UTR3
ADediting_532065	chr16_28476024_-	UTR3
ADediting_532066	chr16_28476046_-	UTR3
ADediting_532067	chr16_28476050_-	UTR3
ADediting_532068	chr16_28476053_-	UTR3
ADediting_532069	chr16_28476054_-	UTR3
ADediting_532070	chr16_28476055_-	UTR3
ADediting_532071	chr16_28476064_-	UTR3
ADediting_532072	chr16_28476069_-	UTR3
ADediting_532073	chr16_28476081_-	UTR3
ADediting_532074	chr16_28476090_-	UTR3
ADediting_532075	chr16_28476114_-	UTR3
ADediting_532076	chr16_28476119_-	UTR3
ADediting_532077	chr16_28476151_-	UTR3
ADediting_532078	chr16_28476159_-	UTR3
ADediting_532079	chr16_28476160_-	UTR3
ADediting_532080	chr16_28476166_-	UTR3
ADediting_532081	chr16_28476283_-	UTR3
ADediting_532082	chr16_28476286_-	UTR3
ADediting_532083	chr16_28476289_-	UTR3
ADediting_532084	chr16_28476298_-	UTR3
ADediting_532085	chr16_28476301_-	UTR3
ADediting_532086	chr16_28476302_-	UTR3
ADediting_532087	chr16_28476325_-	UTR3
ADediting_532088	chr16_28476355_-	UTR3
ADediting_532089	chr16_28476421_-	UTR3
ADediting_532090	chr16_28476434_-	UTR3
ADediting_532091	chr16_28476451_-	UTR3
ADediting_532092	chr16_28476453_-	UTR3
ADediting_532093	chr16_28476462_-	UTR3
ADediting_532094	chr16_28476463_-	UTR3
ADediting_532095	chr16_28476470_-	UTR3
ADediting_532096	chr16_28476510_-	UTR3
ADediting_532097	chr16_28476524_-	UTR3
ADediting_532098	chr16_28476546_-	UTR3
ADediting_532099	chr16_28476880_-	UTR3
ADediting_532100	chr16_28476885_-	UTR3
ADediting_532101	chr16_28476892_-	UTR3
ADediting_532102	chr16_28476907_-	UTR3
ADediting_532103	chr16_28476920_-	UTR3
ADediting_532104	chr16_28476932_-	UTR3
ADediting_532105	chr16_28476934_-	UTR3
ADediting_532106	chr16_28476974_-	UTR3
ADediting_532107	chr16_28476980_-	UTR3
ADediting_532108	chr16_28476982_-	UTR3
ADediting_532109	chr16_28476989_-	UTR3
ADediting_532110	chr16_28477037_-	UTR3
ADediting_532111	chr16_28477050_-	UTR3
ADediting_532112	chr16_28477054_-	UTR3
ADediting_532113	chr16_28477055_-	UTR3
ADediting_532114	chr16_28477067_-	UTR3
ADediting_532115	chr16_28477079_-	UTR3
ADediting_532116	chr16_28477097_-	UTR3
ADediting_532117	chr16_28477114_-	UTR3
ADediting_532118	chr16_28477122_-	UTR3
ADediting_532119	chr16_28477128_-	UTR3
ADediting_532120	chr16_28477130_-	splicing
ADediting_532121	chr16_28478039_-	intronic
ADediting_532122	chr16_28478053_-	intronic
ADediting_532123	chr16_28478054_-	intronic
ADediting_532124	chr16_28478063_-	intronic
ADediting_532125	chr16_28478068_-	intronic
ADediting_532126	chr16_28478081_-	intronic
ADediting_532127	chr16_28478147_-	intronic
ADediting_532128	chr16_28478193_-	intronic
ADediting_532129	chr16_28478197_-	intronic
ADediting_532130	chr16_28478205_-	intronic
ADediting_532131	chr16_28478222_-	intronic
ADediting_532132	chr16_28478229_-	intronic
ADediting_532133	chr16_28478398_-	intronic
ADediting_532134	chr16_28478399_-	intronic
ADediting_532135	chr16_28478433_-	intronic
ADediting_532136	chr16_28478504_-	intronic
ADediting_532137	chr16_28479008_-	intronic
ADediting_532138	chr16_28479009_-	intronic
ADediting_532139	chr16_28479011_-	intronic
ADediting_532140	chr16_28479403_-	intronic
ADediting_532141	chr16_28479423_-	intronic
ADediting_532142	chr16_28479465_-	UTR3
ADediting_532143	chr16_28479475_-	UTR3
ADediting_532144	chr16_28479505_-	UTR3
ADediting_532145	chr16_28479551_-	UTR3
ADediting_532146	chr16_28479556_-	UTR3
ADediting_532147	chr16_28479566_-	UTR3
ADediting_532148	chr16_28479582_-	UTR3
ADediting_532149	chr16_28479588_-	splicing
ADediting_532150	chr16_28479657_-	UTR3
ADediting_532151	chr16_28479669_-	UTR3
ADediting_532152	chr16_28479686_-	UTR3
ADediting_532153	chr16_28479693_-	UTR3
ADediting_532154	chr16_28479722_-	UTR3
ADediting_532155	chr16_28479735_-	exonic
ADediting_532156	chr16_28480026_-	intronic
ADediting_532157	chr16_28480027_-	intronic
ADediting_532158	chr16_28480053_-	intronic
ADediting_532159	chr16_28480058_-	intronic
ADediting_532160	chr16_28480089_-	intronic
ADediting_532161	chr16_28480098_-	intronic
ADediting_532162	chr16_28480099_-	intronic
ADediting_532163	chr16_28480158_-	intronic
ADediting_532164	chr16_28480253_-	intronic
ADediting_532165	chr16_28480285_-	intronic
ADediting_532166	chr16_28480305_-	intronic
ADediting_532167	chr16_28480320_-	intronic
ADediting_532168	chr16_28480349_-	intronic
ADediting_532169	chr16_28480461_-	intronic
ADediting_532170	chr16_28480497_-	intronic
ADediting_532171	chr16_28480506_-	intronic
ADediting_532172	chr16_28480529_-	intronic
ADediting_532173	chr16_28480565_-	intronic
ADediting_532174	chr16_28480569_-	intronic
ADediting_532175	chr16_28480578_-	intronic
ADediting_532176	chr16_28480600_-	intronic
ADediting_532177	chr16_28480653_-	intronic
ADediting_532178	chr16_28480657_-	intronic
ADediting_532179	chr16_28480658_-	intronic
ADediting_532180	chr16_28481070_-	intronic
ADediting_532181	chr16_28481080_-	intronic
ADediting_532182	chr16_28481150_-	intronic
ADediting_532183	chr16_28481154_-	intronic
ADediting_532184	chr16_28481184_-	intronic
ADediting_532185	chr16_28481194_-	intronic
ADediting_532186	chr16_28481203_-	intronic
ADediting_532187	chr16_28481213_-	intronic
ADediting_532188	chr16_28481231_-	intronic
ADediting_532189	chr16_28481238_-	intronic
ADediting_532190	chr16_28481248_-	intronic
ADediting_532191	chr16_28481254_-	intronic
ADediting_532192	chr16_28481256_-	intronic
ADediting_532193	chr16_28481264_-	intronic
ADediting_532194	chr16_28481274_-	intronic
ADediting_532195	chr16_28481319_-	intronic
ADediting_532196	chr16_28481320_-	intronic
ADediting_532197	chr16_28481333_-	intronic
ADediting_532198	chr16_28481347_-	intronic
ADediting_532199	chr16_28481362_-	intronic
ADediting_532200	chr16_28481373_-	intronic
ADediting_532201	chr16_28481374_-	intronic
ADediting_532202	chr16_28481748_-	intronic
ADediting_532203	chr16_28481757_-	intronic
ADediting_532204	chr16_28481775_-	intronic
ADediting_532205	chr16_28481802_-	intronic
ADediting_532206	chr16_28481824_-	intronic
ADediting_532207	chr16_28481839_-	intronic
ADediting_532208	chr16_28481865_-	intronic
ADediting_532209	chr16_28481875_-	intronic
ADediting_532210	chr16_28481904_-	intronic
ADediting_532211	chr16_28481924_-	intronic
ADediting_532212	chr16_28481940_-	intronic
ADediting_532213	chr16_28481946_-	intronic
ADediting_532214	chr16_28482841_-	intronic
ADediting_532215	chr16_28482844_-	intronic
ADediting_532216	chr16_28482912_-	intronic
ADediting_532217	chr16_28482982_-	intronic
ADediting_532218	chr16_28483004_-	intronic
ADediting_532219	chr16_28483448_-	intronic
ADediting_532220	chr16_28483468_-	intronic
ADediting_532221	chr16_28483501_-	intronic
ADediting_532222	chr16_28484417_-	intronic
ADediting_532223	chr16_28484477_-	intronic
ADediting_532224	chr16_28484487_-	intronic
ADediting_532225	chr16_28484584_-	intronic
ADediting_532226	chr16_28485038_-	intronic
ADediting_532227	chr16_28485042_-	intronic
ADediting_532228	chr16_28485043_-	intronic
ADediting_532229	chr16_28485083_-	intronic
ADediting_532230	chr16_28485124_-	intronic
ADediting_532231	chr16_28485127_-	intronic
ADediting_532232	chr16_28485138_-	intronic
ADediting_532233	chr16_28485146_-	intronic
ADediting_532234	chr16_28485177_-	intronic
ADediting_532235	chr16_28485210_-	intronic
ADediting_532236	chr16_28485215_-	intronic
ADediting_532237	chr16_28485216_-	intronic
ADediting_532238	chr16_28485250_-	intronic
ADediting_532239	chr16_28485251_-	intronic
ADediting_532240	chr16_28485312_-	intronic
ADediting_532241	chr16_28485316_-	intronic
ADediting_532242	chr16_28485321_-	intronic
ADediting_532243	chr16_28485410_-	intronic
ADediting_532244	chr16_28485412_-	intronic
ADediting_532245	chr16_28485446_-	intronic
ADediting_532246	chr16_28485456_-	intronic
ADediting_532247	chr16_28485468_-	intronic
ADediting_532248	chr16_28485485_-	intronic
ADediting_532249	chr16_28485516_-	intronic
ADediting_532250	chr16_28486083_-	intronic
ADediting_532251	chr16_28486094_-	intronic
ADediting_532252	chr16_28486113_-	intronic
ADediting_532253	chr16_28486114_-	intronic
ADediting_532254	chr16_28486122_-	intronic
ADediting_532255	chr16_28486162_-	intronic
ADediting_532256	chr16_28486191_-	intronic
ADediting_532257	chr16_28486224_-	intronic
ADediting_532258	chr16_28486225_-	intronic
ADediting_532259	chr16_28486234_-	intronic
ADediting_532260	chr16_28486242_-	intronic
ADediting_532261	chr16_28488977_-	intronic
ADediting_532262	chr16_28489013_-	intronic
ADediting_532263	chr16_28489040_-	intronic
ADediting_1541819	chr16_28474413_-	intronic
ADediting_1541820	chr16_28474899_-	intronic
ADediting_1541821	chr16_28474930_-	intronic
ADediting_1541822	chr16_28475102_-	intronic
ADediting_1541823	chr16_28476060_-	UTR3
ADediting_1541824	chr16_28476063_-	UTR3
ADediting_1541825	chr16_28476351_-	UTR3
ADediting_1541826	chr16_28476402_-	UTR3
ADediting_1541827	chr16_28476540_-	UTR3
ADediting_1541828	chr16_28476988_-	UTR3
ADediting_1541829	chr16_28478359_-	intronic
ADediting_1541830	chr16_28478450_-	intronic
ADediting_1541831	chr16_28478516_-	intronic
ADediting_1541832	chr16_28478529_-	intronic
ADediting_1541833	chr16_28479452_-	intronic
ADediting_1541834	chr16_28480018_-	intronic
ADediting_1541835	chr16_28480023_-	intronic
ADediting_1541836	chr16_28480044_-	intronic
ADediting_1541837	chr16_28480184_-	intronic
ADediting_1541838	chr16_28480326_-	intronic
ADediting_1541839	chr16_28480448_-	intronic
ADediting_1541840	chr16_28480453_-	intronic
ADediting_1541841	chr16_28480458_-	intronic
ADediting_1541842	chr16_28481270_-	intronic
ADediting_1541843	chr16_28481302_-	intronic
ADediting_1541844	chr16_28481365_-	intronic
ADediting_1541845	chr16_28481821_-	intronic
ADediting_1541846	chr16_28481838_-	intronic
ADediting_1541847	chr16_28484609_-	intronic

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_532026	chr16_28474168_-	SINE	Alu	Name=AluSx1
ADediting_532027	chr16_28474185_-	SINE	Alu	Name=AluSx1
ADediting_532028	chr16_28474338_-	SINE	Alu	Name=AluSx
ADediting_532029	chr16_28474360_-	SINE	Alu	Name=AluSx
ADediting_532030	chr16_28474365_-	SINE	Alu	Name=AluSx
ADediting_532031	chr16_28474377_-	SINE	Alu	Name=AluSx
ADediting_532032	chr16_28474868_-	SINE	Alu	Name=AluJr
ADediting_532033	chr16_28474877_-	SINE	Alu	Name=AluJr
ADediting_532034	chr16_28474881_-	SINE	Alu	Name=AluJr
ADediting_532035	chr16_28474885_-	SINE	Alu	Name=AluJr
ADediting_532036	chr16_28474898_-	SINE	Alu	Name=AluJr
ADediting_532037	chr16_28474911_-	SINE	Alu	Name=AluJr
ADediting_532038	chr16_28474937_-	SINE	Alu	Name=AluJr
ADediting_532039	chr16_28474990_-	SINE	Alu	Name=AluJb
ADediting_532040	chr16_28474993_-	SINE	Alu	Name=AluJb
ADediting_532041	chr16_28474999_-	SINE	Alu	Name=AluJb
ADediting_532042	chr16_28475005_-	SINE	Alu	Name=AluJb
ADediting_532043	chr16_28475006_-	SINE	Alu	Name=AluJb
ADediting_532044	chr16_28475032_-	SINE	Alu	Name=AluJb
ADediting_532045	chr16_28475053_-	SINE	Alu	Name=AluJb
ADediting_532046	chr16_28475057_-	SINE	Alu	Name=AluJb
ADediting_532047	chr16_28475095_-	SINE	Alu	Name=AluJb
ADediting_532048	chr16_28475110_-	SINE	Alu	Name=AluJb
ADediting_532049	chr16_28475133_-	SINE	Alu	Name=AluJb
ADediting_532050	chr16_28475134_-	SINE	Alu	Name=AluJb
ADediting_532051	chr16_28475167_-	SINE	Alu	Name=AluJb
ADediting_532052	chr16_28475168_-	SINE	Alu	Name=AluJb
ADediting_532053	chr16_28475181_-	SINE	Alu	Name=AluJb
ADediting_532054	chr16_28475182_-	SINE	Alu	Name=AluJb
ADediting_532055	chr16_28475193_-	SINE	Alu	Name=AluJb
ADediting_532056	chr16_28475214_-	SINE	Alu	Name=AluJb
ADediting_532057	chr16_28475946_-	SINE	Alu	Name=AluSz6
ADediting_532058	chr16_28475951_-	SINE	Alu	Name=AluSz6
ADediting_532059	chr16_28475978_-	SINE	Alu	Name=AluSz6
ADediting_532060	chr16_28475982_-	SINE	Alu	Name=AluSz6
ADediting_532061	chr16_28475994_-	SINE	Alu	Name=AluSz6
ADediting_532062	chr16_28475995_-	SINE	Alu	Name=AluSz6
ADediting_532063	chr16_28476007_-	SINE	Alu	Name=AluSz6
ADediting_532064	chr16_28476014_-	SINE	Alu	Name=AluSz6
ADediting_532065	chr16_28476024_-	SINE	Alu	Name=AluSz6
ADediting_532066	chr16_28476046_-	SINE	Alu	Name=AluSz6
ADediting_532067	chr16_28476050_-	SINE	Alu	Name=AluSz6
ADediting_532068	chr16_28476053_-	SINE	Alu	Name=AluSz6
ADediting_532069	chr16_28476054_-	SINE	Alu	Name=AluSz6
ADediting_532070	chr16_28476055_-	SINE	Alu	Name=AluSz6
ADediting_532071	chr16_28476064_-	SINE	Alu	Name=AluSz6
ADediting_532072	chr16_28476069_-	SINE	Alu	Name=AluSz6
ADediting_532073	chr16_28476081_-	SINE	Alu	Name=AluSz6
ADediting_532074	chr16_28476090_-	SINE	Alu	Name=AluSz6
ADediting_532075	chr16_28476114_-	SINE	Alu	Name=AluSz6
ADediting_532076	chr16_28476119_-	SINE	Alu	Name=AluSz6
ADediting_532077	chr16_28476151_-	SINE	Alu	Name=AluSz6
ADediting_532078	chr16_28476159_-	SINE	Alu	Name=AluSz6
ADediting_532079	chr16_28476160_-	SINE	Alu	Name=AluSz6
ADediting_532080	chr16_28476166_-	SINE	Alu	Name=AluSz6
ADediting_532081	chr16_28476283_-	SINE	Alu	Name=AluJo
ADediting_532082	chr16_28476286_-	SINE	Alu	Name=AluJo
ADediting_532083	chr16_28476289_-	SINE	Alu	Name=AluJo
ADediting_532084	chr16_28476298_-	SINE	Alu	Name=AluJo
ADediting_532085	chr16_28476301_-	SINE	Alu	Name=AluJo
ADediting_532086	chr16_28476302_-	SINE	Alu	Name=AluJo
ADediting_532087	chr16_28476325_-	SINE	Alu	Name=AluJo
ADediting_532088	chr16_28476355_-	SINE	Alu	Name=AluJo
ADediting_532089	chr16_28476421_-	SINE	Alu	Name=AluJo
ADediting_532090	chr16_28476434_-	SINE	Alu	Name=AluJo
ADediting_532091	chr16_28476451_-	SINE	Alu	Name=AluJo
ADediting_532092	chr16_28476453_-	SINE	Alu	Name=AluJo
ADediting_532093	chr16_28476462_-	SINE	Alu	Name=AluJo
ADediting_532094	chr16_28476463_-	SINE	Alu	Name=AluJo
ADediting_532095	chr16_28476470_-	SINE	Alu	Name=AluJo
ADediting_532096	chr16_28476510_-	SINE	Alu	Name=AluJo
ADediting_532097	chr16_28476524_-	SINE	Alu	Name=AluJo
ADediting_532098	chr16_28476546_-	SINE	Alu	Name=AluJo
ADediting_532099	chr16_28476880_-	SINE	Alu	Name=AluSx1
ADediting_532100	chr16_28476885_-	SINE	Alu	Name=AluSx1
ADediting_532101	chr16_28476892_-	SINE	Alu	Name=AluSx1
ADediting_532102	chr16_28476907_-	SINE	Alu	Name=AluSx1
ADediting_532103	chr16_28476920_-	SINE	Alu	Name=AluSx1
ADediting_532104	chr16_28476932_-	SINE	Alu	Name=AluSx1
ADediting_532105	chr16_28476934_-	SINE	Alu	Name=AluSx1
ADediting_532106	chr16_28476974_-	SINE	Alu	Name=AluSx1
ADediting_532107	chr16_28476980_-	SINE	Alu	Name=AluSx1
ADediting_532108	chr16_28476982_-	SINE	Alu	Name=AluSx1
ADediting_532109	chr16_28476989_-	SINE	Alu	Name=AluSx1
ADediting_532110	chr16_28477037_-	SINE	Alu	Name=AluSx1
ADediting_532111	chr16_28477050_-	SINE	Alu	Name=AluSx1
ADediting_532112	chr16_28477054_-	SINE	Alu	Name=AluSx1
ADediting_532113	chr16_28477055_-	SINE	Alu	Name=AluSx1
ADediting_532114	chr16_28477067_-	SINE	Alu	Name=AluSx1
ADediting_532115	chr16_28477079_-	SINE	Alu	Name=AluSx1
ADediting_532116	chr16_28477097_-	SINE	Alu	Name=AluSx1
ADediting_532117	chr16_28477114_-	SINE	Alu	Name=AluSx1
ADediting_532118	chr16_28477122_-	SINE	Alu	Name=AluSx1
ADediting_532119	chr16_28477128_-	SINE	Alu	Name=AluSx1
ADediting_532120	chr16_28477130_-	SINE	Alu	Name=AluSx1
ADediting_532121	chr16_28478039_-	SINE	Alu	Name=AluSx1
ADediting_532122	chr16_28478053_-	SINE	Alu	Name=AluSx1
ADediting_532123	chr16_28478054_-	SINE	Alu	Name=AluSx1
ADediting_532124	chr16_28478063_-	SINE	Alu	Name=AluSx1
ADediting_532125	chr16_28478068_-	SINE	Alu	Name=AluSx1
ADediting_532126	chr16_28478081_-	SINE	Alu	Name=AluSx1
ADediting_532127	chr16_28478147_-	SINE	Alu	Name=AluSx1
ADediting_532128	chr16_28478193_-	SINE	Alu	Name=AluSx1
ADediting_532129	chr16_28478197_-	SINE	Alu	Name=AluSx1
ADediting_532130	chr16_28478205_-	SINE	Alu	Name=AluSx1
ADediting_532131	chr16_28478222_-	SINE	Alu	Name=AluSx1
ADediting_532132	chr16_28478229_-	SINE	Alu	Name=AluSx1
ADediting_532133	chr16_28478398_-	SINE	Alu	Name=AluJr
ADediting_532134	chr16_28478399_-	SINE	Alu	Name=AluJr
ADediting_532135	chr16_28478433_-	SINE	Alu	Name=AluJr
ADediting_532136	chr16_28478504_-	SINE	Alu	Name=AluJr
ADediting_532137	chr16_28479008_-	SINE	Alu	Name=AluJr
ADediting_532138	chr16_28479009_-	SINE	Alu	Name=AluJr
ADediting_532139	chr16_28479011_-	SINE	Alu	Name=AluJr
ADediting_532140	chr16_28479403_-	SINE	Alu	Name=AluSq2
ADediting_532141	chr16_28479423_-	SINE	Alu	Name=AluSq2
ADediting_532142	chr16_28479465_-	SINE	Alu	Name=AluSq2
ADediting_532143	chr16_28479475_-	SINE	Alu	Name=AluSq2
ADediting_532144	chr16_28479505_-	SINE	Alu	Name=AluSq2
ADediting_532145	chr16_28479551_-	SINE	Alu	Name=AluSq2
ADediting_532146	chr16_28479556_-	SINE	Alu	Name=AluSq2
ADediting_532147	chr16_28479566_-	SINE	Alu	Name=AluSq2
ADediting_532148	chr16_28479582_-	SINE	Alu	Name=AluSq2
ADediting_532149	chr16_28479588_-	SINE	Alu	Name=AluSq2
ADediting_532150	chr16_28479657_-	SINE	Alu	Name=AluSx
ADediting_532151	chr16_28479669_-	SINE	Alu	Name=AluSx
ADediting_532152	chr16_28479686_-	SINE	Alu	Name=AluSx
ADediting_532153	chr16_28479693_-	SINE	Alu	Name=AluSx
ADediting_532154	chr16_28479722_-	SINE	Alu	Name=AluSx
ADediting_532155	chr16_28479735_-	SINE	Alu	Name=AluSx
ADediting_532156	chr16_28480026_-	SINE	Alu	Name=AluJo
ADediting_532157	chr16_28480027_-	SINE	Alu	Name=AluJo
ADediting_532158	chr16_28480053_-	SINE	Alu	Name=AluJo
ADediting_532159	chr16_28480058_-	SINE	Alu	Name=AluJo
ADediting_532160	chr16_28480089_-	SINE	Alu	Name=AluJo
ADediting_532161	chr16_28480098_-	SINE	Alu	Name=AluJo
ADediting_532162	chr16_28480099_-	SINE	Alu	Name=AluJo
ADediting_532163	chr16_28480158_-	SINE	Alu	Name=AluJo
ADediting_532164	chr16_28480253_-	SINE	Alu	Name=AluJb
ADediting_532165	chr16_28480285_-	SINE	Alu	Name=AluJb
ADediting_532166	chr16_28480305_-	SINE	Alu	Name=AluJb
ADediting_532167	chr16_28480320_-	SINE	Alu	Name=AluJb
ADediting_532168	chr16_28480349_-	SINE	Alu	Name=AluJb
ADediting_532169	chr16_28480461_-	SINE	Alu	Name=AluSx
ADediting_532170	chr16_28480497_-	SINE	Alu	Name=AluSx
ADediting_532171	chr16_28480506_-	SINE	Alu	Name=AluSx
ADediting_532172	chr16_28480529_-	SINE	Alu	Name=AluSx
ADediting_532173	chr16_28480565_-	SINE	Alu	Name=AluSx
ADediting_532174	chr16_28480569_-	SINE	Alu	Name=AluSx
ADediting_532175	chr16_28480578_-	SINE	Alu	Name=AluSx
ADediting_532176	chr16_28480600_-	SINE	Alu	Name=AluSx
ADediting_532177	chr16_28480653_-	SINE	Alu	Name=AluSx
ADediting_532178	chr16_28480657_-	SINE	Alu	Name=AluSx
ADediting_532179	chr16_28480658_-	SINE	Alu	Name=AluSx
ADediting_532180	chr16_28481070_-	SINE	Alu	Name=FRAM
ADediting_532181	chr16_28481080_-	SINE	Alu	Name=FRAM
ADediting_532182	chr16_28481150_-	SINE	Alu	Name=AluJb
ADediting_532183	chr16_28481154_-	SINE	Alu	Name=AluJb
ADediting_532184	chr16_28481184_-	SINE	Alu	Name=AluJb
ADediting_532185	chr16_28481194_-	SINE	Alu	Name=AluJb
ADediting_532186	chr16_28481203_-	SINE	Alu	Name=AluJb
ADediting_532187	chr16_28481213_-	SINE	Alu	Name=AluJb
ADediting_532188	chr16_28481231_-	SINE	Alu	Name=AluJb
ADediting_532189	chr16_28481238_-	SINE	Alu	Name=AluJb
ADediting_532190	chr16_28481248_-	SINE	Alu	Name=AluJb
ADediting_532191	chr16_28481254_-	SINE	Alu	Name=AluJb
ADediting_532192	chr16_28481256_-	SINE	Alu	Name=AluJb
ADediting_532193	chr16_28481264_-	SINE	Alu	Name=AluJb
ADediting_532194	chr16_28481274_-	SINE	Alu	Name=AluJb
ADediting_532195	chr16_28481319_-	SINE	Alu	Name=AluJb
ADediting_532196	chr16_28481320_-	SINE	Alu	Name=AluJb
ADediting_532197	chr16_28481333_-	SINE	Alu	Name=AluJb
ADediting_532198	chr16_28481347_-	SINE	Alu	Name=AluJb
ADediting_532199	chr16_28481362_-	SINE	Alu	Name=AluJb
ADediting_532200	chr16_28481373_-	SINE	Alu	Name=AluJb
ADediting_532201	chr16_28481374_-	SINE	Alu	Name=AluJb
ADediting_532202	chr16_28481748_-	SINE	Alu	Name=AluSx1
ADediting_532203	chr16_28481757_-	SINE	Alu	Name=AluSx1
ADediting_532204	chr16_28481775_-	SINE	Alu	Name=AluSx1
ADediting_532205	chr16_28481802_-	SINE	Alu	Name=AluSx1
ADediting_532206	chr16_28481824_-	SINE	Alu	Name=AluSx1
ADediting_532207	chr16_28481839_-	SINE	Alu	Name=AluSx1
ADediting_532208	chr16_28481865_-	SINE	Alu	Name=AluSx1
ADediting_532209	chr16_28481875_-	SINE	Alu	Name=AluSx1
ADediting_532210	chr16_28481904_-	SINE	Alu	Name=AluSx1
ADediting_532211	chr16_28481924_-	SINE	Alu	Name=AluSx1
ADediting_532212	chr16_28481940_-	SINE	Alu	Name=AluSx1
ADediting_532213	chr16_28481946_-	SINE	Alu	Name=AluSx1
ADediting_532214	chr16_28482841_-	SINE	Alu	Name=AluSq2
ADediting_532215	chr16_28482844_-	SINE	Alu	Name=AluSq2
ADediting_532216	chr16_28482912_-	SINE	Alu	Name=AluSq2
ADediting_532217	chr16_28482982_-	SINE	Alu	Name=AluSq2
ADediting_532218	chr16_28483004_-	SINE	Alu	Name=AluSq2
ADediting_532219	chr16_28483448_-	SINE	Alu	Name=AluSz6
ADediting_532220	chr16_28483468_-	SINE	Alu	Name=AluSz6
ADediting_532221	chr16_28483501_-	SINE	Alu	Name=AluSz6
ADediting_532222	chr16_28484417_-	SINE	Alu	Name=AluJr
ADediting_532223	chr16_28484477_-	SINE	Alu	Name=AluJr
ADediting_532224	chr16_28484487_-	SINE	Alu	Name=AluJr
ADediting_532225	chr16_28484584_-	SINE	Alu	Name=AluJr
ADediting_532226	chr16_28485038_-	SINE	Alu	Name=AluSx4
ADediting_532227	chr16_28485042_-	SINE	Alu	Name=AluSx4
ADediting_532228	chr16_28485043_-	SINE	Alu	Name=AluSx4
ADediting_532229	chr16_28485083_-	SINE	Alu	Name=AluSx4
ADediting_532230	chr16_28485124_-	SINE	Alu	Name=AluSx4
ADediting_532231	chr16_28485127_-	SINE	Alu	Name=AluSx4
ADediting_532232	chr16_28485138_-	SINE	Alu	Name=AluSx4
ADediting_532233	chr16_28485146_-	SINE	Alu	Name=AluSx4
ADediting_532234	chr16_28485177_-	SINE	Alu	Name=AluSx4
ADediting_532235	chr16_28485210_-	SINE	Alu	Name=AluSx4
ADediting_532236	chr16_28485215_-	SINE	Alu	Name=AluSx4
ADediting_532237	chr16_28485216_-	SINE	Alu	Name=AluSx4
ADediting_532238	chr16_28485250_-	DNA	hAT-Charlie	Name=MER113B
ADediting_532239	chr16_28485251_-	DNA	hAT-Charlie	Name=MER113B
ADediting_532240	chr16_28485312_-	SINE	Alu	Name=AluSz
ADediting_532241	chr16_28485316_-	SINE	Alu	Name=AluSz
ADediting_532242	chr16_28485321_-	SINE	Alu	Name=AluSz
ADediting_532243	chr16_28485410_-	SINE	Alu	Name=AluSz
ADediting_532244	chr16_28485412_-	SINE	Alu	Name=AluSz
ADediting_532245	chr16_28485446_-	SINE	Alu	Name=AluSz
ADediting_532246	chr16_28485456_-	SINE	Alu	Name=AluSz
ADediting_532247	chr16_28485468_-	SINE	Alu	Name=AluSz
ADediting_532248	chr16_28485485_-	SINE	Alu	Name=AluSz
ADediting_532249	chr16_28485516_-	SINE	Alu	Name=AluSz
ADediting_532250	chr16_28486083_-	SINE	Alu	Name=AluSx1
ADediting_532251	chr16_28486094_-	SINE	Alu	Name=AluSx1
ADediting_532252	chr16_28486113_-	SINE	Alu	Name=AluSx1
ADediting_532253	chr16_28486114_-	SINE	Alu	Name=AluSx1
ADediting_532254	chr16_28486122_-	SINE	Alu	Name=AluSx1
ADediting_532255	chr16_28486162_-	SINE	Alu	Name=AluSx1
ADediting_532256	chr16_28486191_-	SINE	Alu	Name=AluSx1
ADediting_532257	chr16_28486224_-	SINE	Alu	Name=AluSx1
ADediting_532258	chr16_28486225_-	SINE	Alu	Name=AluSx1
ADediting_532259	chr16_28486234_-	SINE	Alu	Name=AluSx1
ADediting_532260	chr16_28486242_-	SINE	Alu	Name=AluSx1
ADediting_532261	chr16_28488977_-	SINE	Alu	Name=AluSz
ADediting_532262	chr16_28489013_-	SINE	Alu	Name=AluSz
ADediting_532263	chr16_28489040_-	SINE	Alu	Name=AluSz
ADediting_1541819	chr16_28474413_-	SINE	Alu	Name=AluSx
ADediting_1541820	chr16_28474899_-	SINE	Alu	Name=AluJr
ADediting_1541821	chr16_28474930_-	SINE	Alu	Name=AluJr
ADediting_1541822	chr16_28475102_-	SINE	Alu	Name=AluJb
ADediting_1541823	chr16_28476060_-	SINE	Alu	Name=AluSz6
ADediting_1541824	chr16_28476063_-	SINE	Alu	Name=AluSz6
ADediting_1541825	chr16_28476351_-	SINE	Alu	Name=AluJo
ADediting_1541826	chr16_28476402_-	SINE	Alu	Name=AluJo
ADediting_1541827	chr16_28476540_-	SINE	Alu	Name=AluJo
ADediting_1541828	chr16_28476988_-	SINE	Alu	Name=AluSx1
ADediting_1541829	chr16_28478359_-	SINE	Alu	Name=AluJr
ADediting_1541830	chr16_28478450_-	SINE	Alu	Name=AluJr
ADediting_1541831	chr16_28478516_-	SINE	Alu	Name=AluJr
ADediting_1541832	chr16_28478529_-	SINE	Alu	Name=AluJr
ADediting_1541833	chr16_28479452_-	SINE	Alu	Name=AluSq2
ADediting_1541834	chr16_28480018_-	SINE	Alu	Name=AluJo
ADediting_1541835	chr16_28480023_-	SINE	Alu	Name=AluJo
ADediting_1541836	chr16_28480044_-	SINE	Alu	Name=AluJo
ADediting_1541837	chr16_28480184_-	SINE	Alu	Name=AluJo
ADediting_1541838	chr16_28480326_-	SINE	Alu	Name=AluJb
ADediting_1541839	chr16_28480448_-	SINE	Alu	Name=AluSx
ADediting_1541840	chr16_28480453_-	SINE	Alu	Name=AluSx
ADediting_1541841	chr16_28480458_-	SINE	Alu	Name=AluSx
ADediting_1541842	chr16_28481270_-	SINE	Alu	Name=AluJb
ADediting_1541843	chr16_28481302_-	SINE	Alu	Name=AluJb
ADediting_1541844	chr16_28481365_-	SINE	Alu	Name=AluJb
ADediting_1541845	chr16_28481821_-	SINE	Alu	Name=AluSx1
ADediting_1541846	chr16_28481838_-	SINE	Alu	Name=AluSx1
ADediting_1541847	chr16_28484609_-	SINE	Alu	Name=AluJr

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RNA A-to-I editing events in the alternative splicing sites for CLN3

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	ADeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	ADediting_532149	chr16_28479588_-	28479584:28479606	3ss	2i	TGTTTTGTTTTGTTTTTTAGAGA	10.57	TGTTTTGTTTTGTTTTTTGGAGA	2.62
ME2	ADediting_532149	chr16_28479588_-	28479584:28479606	3ss	2i	TGTTTTGTTTTGTTTTTTAGAGA	10.57	TGTTTTGTTTTGTTTTTTGGAGA	2.62

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CLN3

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

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Protein coding region RNA A-to-I editings for CLN3

- Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CLN3

RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1541823	chr16_28476060_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-153-5p	chr16	28476060	28476066	7mer-m8	28476059	28476081	144	-8.73
ADediting_1541825	chr16_28476351_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-3940-3p	chr16	28476347	28476353	7mer-m8	28476346	28476367	146	-19.24
ADediting_1541827	chr16_28476540_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-340-3p	chr16	28476539	28476545	7mer-m8	28476538	28476559	140	-15.89
ADediting_1541827	chr16_28476540_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6827-3p	chr16	28476539	28476545	7mer-m8	28476538	28476558	145	-16.55
ADediting_1541828	chr16_28476988_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-548ae-3p	chr16	28476982	28476989	8mer-1a	28476982	28477003	143	-6.84
ADediting_1541828	chr16_28476988_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-548ah-3p	chr16	28476982	28476989	8mer-1a	28476982	28477005	146	-7.79
ADediting_1541828	chr16_28476988_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-548aj-3p	chr16	28476982	28476989	8mer-1a	28476982	28477003	143	-9.34
ADediting_1541828	chr16_28476988_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-548am-3p	chr16	28476982	28476989	8mer-1a	28476982	28477005	146	-7.61
ADediting_1541828	chr16_28476988_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-548aq-3p	chr16	28476982	28476989	8mer-1a	28476982	28477004	143	-7.22
ADediting_1541828	chr16_28476988_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-548j-3p	chr16	28476982	28476989	8mer-1a	28476982	28477003	144	-6.91
ADediting_1541828	chr16_28476988_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-548x-3p	chr16	28476982	28476989	8mer-1a	28476982	28477002	143	-9.34
ADediting_1541828	chr16_28476988_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-7844-5p	chr16	28476985	28476991	7mer-m8	28476984	28477008	156	-20.55
ADediting_532058	chr16_28475951_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-891b	chr16	28475946	28475953	8mer-1a	28475946	28475967	148	-14.53
ADediting_532060	chr16_28475982_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-10400-3p	chr16	28475978	28475984	7mer-m8	28475977	28475998	141	-24.72
ADediting_532060	chr16_28475982_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4437	chr16	28475978	28475985	8mer-1a	28475978	28475998	146	-19.59
ADediting_532060	chr16_28475982_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4674	chr16	28475978	28475984	7mer-m8	28475977	28475997	147	-22.97
ADediting_532061	chr16_28475994_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-1539	chr16	28475992	28475999	8mer-1a	28475992	28476012	147	-21.92
ADediting_532061	chr16_28475994_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-3074-5p	chr16	28475991	28475997	7mer-m8	28475990	28476008	151	-22.48
ADediting_532063	chr16_28476007_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4290	chr16	28476004	28476010	7mer-m8	28476003	28476021	140	-14.16
ADediting_532063	chr16_28476007_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4687-5p	chr16	28476003	28476009	7mer-m8	28476002	28476023	145	-21.5
ADediting_532063	chr16_28476007_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-5695	chr16	28476007	28476013	7mer-m8	28476006	28476027	147	-15.78
ADediting_532064	chr16_28476014_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-1207-3p	chr16	28476014	28476020	7mer-m8	28476013	28476031	145	-13.53
ADediting_532064	chr16_28476014_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-646	chr16	28476012	28476018	7mer-m8	28476011	28476030	148	-21.85
ADediting_532065	chr16_28476024_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-140-3p	chr16	28476022	28476028	7mer-m8	28476021	28476041	160	-24.62
ADediting_532066	chr16_28476046_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-941	chr16	28476043	28476049	7mer-m8	28476042	28476064	149	-23.05
ADediting_532067	chr16_28476050_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-3190-5p	chr16	28476045	28476051	7mer-m8	28476044	28476063	143	-16.24
ADediting_532067	chr16_28476050_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-548s	chr16	28476046	28476052	7mer-m8	28476045	28476068	144	-11.72
ADediting_532073	chr16_28476081_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-193a-5p	chr16	28476077	28476083	7mer-m8	28476076	28476097	142	-15.92
ADediting_532076	chr16_28476119_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4726-3p	chr16	28476118	28476124	7mer-m8	28476117	28476136	153	-29.39
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-518a-3p	chr16	28476147	28476153	7mer-m8	28476146	28476167	145	-17.16
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-518b	chr16	28476147	28476153	7mer-m8	28476146	28476166	146	-21.8
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-518c-3p	chr16	28476147	28476153	7mer-m8	28476146	28476168	146	-21.31
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-518d-3p	chr16	28476147	28476153	7mer-m8	28476146	28476166	145	-17.84
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-518e-3p	chr16	28476148	28476154	7mer-m8	28476147	28476168	144	-19.12
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-518f-3p	chr16	28476147	28476153	7mer-m8	28476146	28476166	145	-17.49
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-526a-3p	chr16	28476147	28476153	7mer-m8	28476146	28476166	146	-17.72
ADediting_532079	chr16_28476160_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-513a-5p	chr16	28476159	28476165	7mer-m8	28476158	28476175	144	-17.77
ADediting_532079	chr16_28476160_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-638	chr16	28476154	28476160	7mer-1a	28476154	28476178	149	-31.67
ADediting_532082	chr16_28476286_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6514-3p	chr16	28476283	28476289	7mer-m8	28476282	28476302	151	-13.6
ADediting_532083	chr16_28476289_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4327	chr16	28476283	28476290	8mer-1a	28476283	28476301	140	-11.52
ADediting_532084	chr16_28476298_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-383-3p	chr16	28476294	28476301	8mer-1a	28476294	28476314	144	-19.45
ADediting_532085	chr16_28476301_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-3189-3p	chr16	28476300	28476306	7mer-m8	28476299	28476318	141	-22.4
ADediting_532085	chr16_28476301_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6813-3p	chr16	28476298	28476305	8mer-1a	28476298	28476318	140	-13.48
ADediting_532086	chr16_28476302_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-326	chr16	28476300	28476306	7mer-m8	28476299	28476318	140	-15.33
ADediting_532086	chr16_28476302_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-330-5p	chr16	28476300	28476306	7mer-m8	28476299	28476320	140	-22.45
ADediting_532086	chr16_28476302_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4314	chr16	28476301	28476307	7mer-m8	28476300	28476317	140	-18.79
ADediting_532086	chr16_28476302_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-514a-5p	chr16	28476298	28476305	8mer-1a	28476298	28476318	154	-19.41
ADediting_532088	chr16_28476355_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-196a-3p	chr16	28476353	28476359	7mer-m8	28476352	28476374	148	-11.58
ADediting_532088	chr16_28476355_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-3187-5p	chr16	28476350	28476356	7mer-m8	28476349	28476370	158	-29.29
ADediting_532088	chr16_28476355_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-5189-5p	chr16	28476350	28476356	7mer-m8	28476349	28476375	153	-23.13
ADediting_532088	chr16_28476355_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-612	chr16	28476350	28476356	7mer-m8	28476349	28476372	144	-16.17
ADediting_532088	chr16_28476355_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6860	chr16	28476350	28476356	7mer-m8	28476349	28476369	146	-18.47
ADediting_532089	chr16_28476421_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-17-3p	chr16	28476421	28476427	7mer-m8	28476420	28476442	150	-20.08
ADediting_532089	chr16_28476421_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-500a-3p	chr16	28476416	28476422	7mer-m8	28476415	28476436	145	-20.13
ADediting_532089	chr16_28476421_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6804-3p	chr16	28476416	28476423	8mer-1a	28476416	28476438	156	-19.98
ADediting_532092	chr16_28476453_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4737	chr16	28476451	28476457	7mer-m8	28476450	28476469	150	-17.71
ADediting_532095	chr16_28476470_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-665	chr16	28476468	28476475	8mer-1a	28476468	28476487	164	-27.02
ADediting_532096	chr16_28476510_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4325	chr16	28476508	28476514	7mer-m8	28476507	28476526	147	-18.05
ADediting_532096	chr16_28476510_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4793-3p	chr16	28476507	28476513	7mer-m8	28476506	28476528	158	-22.35
ADediting_532097	chr16_28476524_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4486	chr16	28476519	28476525	7mer-m8	28476518	28476534	145	-18.58
ADediting_532098	chr16_28476546_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-515-5p	chr16	28476542	28476548	7mer-m8	28476541	28476564	161	-12.47
ADediting_532098	chr16_28476546_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-519d-5p	chr16	28476542	28476549	8mer-1a	28476542	28476566	150	-11.66
ADediting_532098	chr16_28476546_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-519e-5p	chr16	28476542	28476548	7mer-m8	28476541	28476562	157	-12.33
ADediting_532098	chr16_28476546_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-5695	chr16	28476542	28476548	7mer-1a	28476542	28476563	143	-11.2
ADediting_532100	chr16_28476885_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-7977	chr16	28476883	28476889	7mer-m8	28476882	28476899	140	-13.07
ADediting_532101	chr16_28476892_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-3189-3p	chr16	28476891	28476897	7mer-m8	28476890	28476909	145	-19.31
ADediting_532101	chr16_28476892_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6813-3p	chr16	28476890	28476896	7mer-m8	28476889	28476909	140	-16.1
ADediting_532102	chr16_28476907_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4767	chr16	28476906	28476912	7mer-m8	28476905	28476930	146	-22.47
ADediting_532104	chr16_28476932_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-556-5p	chr16	28476927	28476933	7mer-m8	28476926	28476947	140	-10.91
ADediting_532107	chr16_28476980_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4803	chr16	28476978	28476984	7mer-m8	28476977	28476996	150	-8.18
ADediting_532109	chr16_28476989_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-3157-5p	chr16	28476988	28476994	7mer-m8	28476987	28477007	158	-22.97
ADediting_532109	chr16_28476989_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-34a-3p	chr16	28476986	28476992	7mer-m8	28476985	28477004	150	-10.66
ADediting_532110	chr16_28477037_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6089	chr16	28477032	28477038	7mer-m8	28477031	28477054	164	-37.08
ADediting_532111	chr16_28477050_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-146a-5p	chr16	28477045	28477051	7mer-m8	28477044	28477064	150	-20.54
ADediting_532111	chr16_28477050_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-146b-5p	chr16	28477045	28477051	7mer-m8	28477044	28477065	150	-15.48
ADediting_532111	chr16_28477050_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-7153-5p	chr16	28477045	28477051	7mer-m8	28477044	28477066	145	-16.74
ADediting_532114	chr16_28477067_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-658	chr16	28477066	28477072	7mer-m8	28477065	28477091	153	-26.63
ADediting_532114	chr16_28477067_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-7846-3p	chr16	28477065	28477071	7mer-m8	28477064	28477084	158	-18.44
ADediting_532116	chr16_28477097_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-324-3p	chr16	28477094	28477100	7mer-m8	28477093	28477117	147	-22.82
ADediting_532116	chr16_28477097_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4252	chr16	28477093	28477099	7mer-m8	28477092	28477112	149	-21.82
ADediting_532116	chr16_28477097_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4793-3p	chr16	28477097	28477103	7mer-m8	28477096	28477118	153	-20.11
ADediting_532119	chr16_28477128_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-10a-5p	chr16	28477126	28477132	7mer-m8	28477125	28477147	154	-14.73
ADediting_532119	chr16_28477128_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-10b-5p	chr16	28477126	28477132	7mer-m8	28477125	28477147	162	-16.52
ADediting_532119	chr16_28477128_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-339-5p	chr16	28477127	28477133	7mer-m8	28477126	28477148	140	-17.55
ADediting_532119	chr16_28477128_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4725-5p	chr16	28477125	28477131	7mer-m8	28477124	28477145	142	-16.77
ADediting_532119	chr16_28477128_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-504-5p	chr16	28477125	28477131	7mer-m8	28477124	28477144	146	-16.71

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1541825	chr16_28476351_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-661	chr16	28476348	28476354	7mer-m8	28476347	28476371	146	-22.71
ADediting_1541825	chr16_28476351_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6742-3p	chr16	28476349	28476355	7mer-m8	28476348	28476367	140	-13.8
ADediting_1541825	chr16_28476351_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6861-5p	chr16	28476350	28476356	7mer-m8	28476349	28476371	150	-20.56
ADediting_1541827	chr16_28476540_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-10a-5p	chr16	28476536	28476542	7mer-m8	28476535	28476557	146	-13.67
ADediting_1541827	chr16_28476540_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-10b-5p	chr16	28476536	28476542	7mer-m8	28476535	28476557	140	-12.21
ADediting_1541827	chr16_28476540_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-339-5p	chr16	28476537	28476543	7mer-m8	28476536	28476557	151	-17.76
ADediting_1541827	chr16_28476540_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-5699-3p	chr16	28476538	28476544	7mer-m8	28476537	28476558	146	-16.39
ADediting_1541827	chr16_28476540_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6818-3p	chr16	28476540	28476546	7mer-m8	28476539	28476560	140	-11.1
ADediting_532058	chr16_28475951_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-205-3p	chr16	28475950	28475956	7mer-m8	28475949	28475969	143	-10.26
ADediting_532059	chr16_28475978_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-1343-3p	chr16	28475975	28475981	7mer-m8	28475974	28475997	145	-24.52
ADediting_532059	chr16_28475978_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6742-3p	chr16	28475975	28475982	8mer-1a	28475975	28475994	145	-14.93
ADediting_532059	chr16_28475978_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6783-3p	chr16	28475975	28475981	7mer-m8	28475974	28475994	146	-18.44
ADediting_532060	chr16_28475982_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-498-5p	chr16	28475982	28475988	7mer-m8	28475981	28476004	144	-15.69
ADediting_532063	chr16_28476007_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-3614-3p	chr16	28476003	28476009	7mer-m8	28476002	28476026	148	-16.67
ADediting_532063	chr16_28476007_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4297	chr16	28476004	28476010	7mer-m8	28476003	28476021	141	-14.92
ADediting_532063	chr16_28476007_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-5581-5p	chr16	28476004	28476010	7mer-m8	28476003	28476023	153	-27.12
ADediting_532064	chr16_28476014_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-562	chr16	28476011	28476017	7mer-m8	28476010	28476030	151	-13.75
ADediting_532064	chr16_28476014_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-5697	chr16	28476010	28476016	7mer-m8	28476009	28476030	146	-18.02
ADediting_532065	chr16_28476024_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-3199	chr16	28476018	28476024	7mer-1a	28476018	28476037	141	-19.24
ADediting_532065	chr16_28476024_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-8052	chr16	28476018	28476024	7mer-1a	28476018	28476038	145	-22.14
ADediting_532066	chr16_28476046_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4794	chr16	28476045	28476051	7mer-m8	28476044	28476065	140	-12.23
ADediting_532066	chr16_28476046_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-664a-5p	chr16	28476045	28476051	7mer-m8	28476044	28476067	141	-13.1
ADediting_532066	chr16_28476046_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6765-3p	chr16	28476042	28476048	7mer-m8	28476041	28476061	152	-20.77
ADediting_532067	chr16_28476050_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4735-5p	chr16	28476049	28476055	7mer-m8	28476048	28476069	140	-8.12
ADediting_532067	chr16_28476050_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4794	chr16	28476045	28476051	7mer-m8	28476044	28476065	140	-12.23
ADediting_532067	chr16_28476050_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-664a-5p	chr16	28476045	28476051	7mer-m8	28476044	28476067	141	-13.1
ADediting_532068	chr16_28476053_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4735-5p	chr16	28476049	28476055	7mer-m8	28476048	28476069	140	-8.12
ADediting_532069	chr16_28476054_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4735-5p	chr16	28476049	28476055	7mer-m8	28476048	28476069	140	-8.12
ADediting_532072	chr16_28476069_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6832-5p	chr16	28476068	28476074	7mer-m8	28476067	28476089	142	-14.99
ADediting_532073	chr16_28476081_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-193b-5p	chr16	28476076	28476082	7mer-m8	28476075	28476096	150	-22.83
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-302a-3p	chr16	28476148	28476154	7mer-m8	28476147	28476168	147	-15.45
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-302b-3p	chr16	28476148	28476154	7mer-m8	28476147	28476174	144	-10.15
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-302c-3p	chr16	28476148	28476154	7mer-m8	28476147	28476167	145	-11.96
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-302d-3p	chr16	28476148	28476154	7mer-m8	28476147	28476174	152	-14.53
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-302e	chr16	28476148	28476154	7mer-m8	28476147	28476163	141	-8.62
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-512-3p	chr16	28476149	28476155	7mer-m8	28476148	28476172	151	-17.94
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-519d-3p	chr16	28476147	28476153	7mer-m8	28476146	28476166	146	-14.54
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-520a-3p	chr16	28476148	28476154	7mer-m8	28476147	28476168	140	-11.04
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-520b-3p	chr16	28476148	28476154	7mer-m8	28476147	28476166	141	-16.53
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-520c-3p	chr16	28476148	28476154	7mer-m8	28476147	28476167	146	-16.53
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-520d-3p	chr16	28476148	28476154	7mer-m8	28476147	28476170	142	-15.59
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-520e-3p	chr16	28476148	28476154	7mer-m8	28476147	28476167	140	-13.33
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-520g-3p	chr16	28476146	28476152	7mer-m8	28476145	28476168	151	-19.1
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-520h	chr16	28476146	28476152	7mer-m8	28476145	28476166	150	-15.08
ADediting_532077	chr16_28476151_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-526b-3p	chr16	28476147	28476153	7mer-m8	28476146	28476166	146	-16.21
ADediting_532078	chr16_28476159_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-10399-5p	chr16	28476158	28476164	7mer-m8	28476157	28476178	150	-14
ADediting_532078	chr16_28476159_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-5089-5p	chr16	28476154	28476160	7mer-m8	28476153	28476175	148	-13.62
ADediting_532078	chr16_28476159_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6504-3p	chr16	28476158	28476164	7mer-m8	28476157	28476178	144	-13.86
ADediting_532079	chr16_28476160_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-10399-5p	chr16	28476158	28476164	7mer-m8	28476157	28476178	150	-14
ADediting_532079	chr16_28476160_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6504-3p	chr16	28476158	28476164	7mer-m8	28476157	28476178	144	-13.86
ADediting_532080	chr16_28476166_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-3934-5p	chr16	28476162	28476168	7mer-m8	28476161	28476183	151	-21.25
ADediting_532080	chr16_28476166_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-552-3p	chr16	28476160	28476167	8mer-1a	28476160	28476179	142	-13.72
ADediting_532081	chr16_28476283_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6847-3p	chr16	28476278	28476284	7mer-m8	28476277	28476298	155	-20.12
ADediting_532084	chr16_28476298_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4797-3p	chr16	28476292	28476299	8mer-1a	28476292	28476313	142	-16.65
ADediting_532086	chr16_28476302_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-887-5p	chr16	28476301	28476308	8mer-1a	28476301	28476323	149	-19.3
ADediting_532088	chr16_28476355_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6861-5p	chr16	28476350	28476356	7mer-m8	28476349	28476371	150	-20.56
ADediting_532089	chr16_28476421_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4325	chr16	28476416	28476422	7mer-m8	28476415	28476435	155	-19.99
ADediting_532091	chr16_28476451_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4761-5p	chr16	28476446	28476452	7mer-m8	28476445	28476464	152	-15.89
ADediting_532093	chr16_28476462_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4445-5p	chr16	28476457	28476463	7mer-m8	28476456	28476477	145	-7.04
ADediting_532094	chr16_28476463_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-8081	chr16	28476462	28476469	8mer-1a	28476462	28476484	140	-8.34
ADediting_532095	chr16_28476470_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4266	chr16	28476470	28476476	7mer-m8	28476469	28476484	146	-22.37
ADediting_532095	chr16_28476470_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-8078	chr16	28476467	28476473	7mer-m8	28476466	28476486	144	-18.05
ADediting_532097	chr16_28476524_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-1262	chr16	28476520	28476526	7mer-m8	28476519	28476540	142	-15.14
ADediting_532097	chr16_28476524_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6736-5p	chr16	28476520	28476526	7mer-m8	28476519	28476543	146	-23.84
ADediting_532097	chr16_28476524_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6776-5p	chr16	28476519	28476525	7mer-m8	28476518	28476537	150	-20.01
ADediting_532098	chr16_28476546_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-520f-5p	chr16	28476542	28476549	8mer-1a	28476542	28476563	150	-9.49
ADediting_532100	chr16_28476885_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-216a-5p	chr16	28476880	28476887	8mer-1a	28476880	28476901	150	-16.7
ADediting_532102	chr16_28476907_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-1228-5p	chr16	28476907	28476913	7mer-m8	28476906	28476925	145	-24.49
ADediting_532102	chr16_28476907_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-541-3p	chr16	28476905	28476911	7mer-m8	28476904	28476925	155	-22.36
ADediting_532102	chr16_28476907_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-654-5p	chr16	28476905	28476911	7mer-m8	28476904	28476924	149	-19.51
ADediting_532103	chr16_28476920_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-3622a-3p	chr16	28476915	28476922	8mer-1a	28476915	28476934	146	-17.1
ADediting_532103	chr16_28476920_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-3622b-3p	chr16	28476915	28476922	8mer-1a	28476915	28476935	153	-20.68
ADediting_532103	chr16_28476920_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-7162-3p	chr16	28476919	28476925	7mer-m8	28476918	28476936	140	-14.54
ADediting_532110	chr16_28477037_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4478	chr16	28477033	28477039	7mer-m8	28477032	28477047	149	-25.05
ADediting_532110	chr16_28477037_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4649-3p	chr16	28477036	28477042	7mer-m8	28477035	28477055	140	-14.11
ADediting_532110	chr16_28477037_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-7160-5p	chr16	28477035	28477041	7mer-m8	28477034	28477054	147	-20.02
ADediting_532111	chr16_28477050_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-219b-3p	chr16	28477047	28477053	7mer-m8	28477046	28477066	153	-15.53
ADediting_532111	chr16_28477050_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-302f	chr16	28477048	28477054	7mer-m8	28477047	28477063	145	-7.17
ADediting_532114	chr16_28477067_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-12117	chr16	28477064	28477070	7mer-m8	28477063	28477082	145	-23.8
ADediting_532114	chr16_28477067_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4795-5p	chr16	28477063	28477069	7mer-m8	28477062	28477082	140	-11.15
ADediting_532114	chr16_28477067_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-7847-3p	chr16	28477066	28477072	7mer-m8	28477065	28477087	146	-18.89
ADediting_532115	chr16_28477079_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6807-5p	chr16	28477079	28477085	7mer-m8	28477078	28477099	144	-19.38
ADediting_532116	chr16_28477097_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-32-5p	chr16	28477096	28477102	7mer-m8	28477095	28477117	155	-14.06
ADediting_532116	chr16_28477097_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-363-3p	chr16	28477096	28477102	7mer-m8	28477095	28477116	147	-14.18
ADediting_532116	chr16_28477097_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-92a-3p	chr16	28477096	28477102	7mer-m8	28477095	28477112	155	-24.98
ADediting_532116	chr16_28477097_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-92b-3p	chr16	28477096	28477102	7mer-m8	28477095	28477112	155	-23.78
ADediting_532118	chr16_28477122_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-6864-3p	chr16	28477122	28477128	7mer-m8	28477121	28477140	148	-16.5
ADediting_532118	chr16_28477122_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-759	chr16	28477117	28477123	7mer-m8	28477116	28477136	146	-15.6
ADediting_532119	chr16_28477128_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-3664-5p	chr16	28477126	28477132	7mer-m8	28477125	28477146	152	-13.9
ADediting_532119	chr16_28477128_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4522	chr16	28477125	28477131	7mer-m8	28477124	28477144	142	-13.87
ADediting_532120	chr16_28477130_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-3664-5p	chr16	28477126	28477132	7mer-m8	28477125	28477146	152	-13.9
ADediting_532120	chr16_28477130_-	ENSG00000188603.19	ENST00000636147.1	CLN3-244	hsa-miR-4522	chr16	28477125	28477131	7mer-m8	28477124	28477144	142	-13.87

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_843620

chr2_207754818_+

ENSG00000188603.19

ENST00000636147.1

CLN3-244

hsa-miR-4775

chr16

28475724

28475730

7mer-m8

28475723

28475748

149

-10.6

ADediting_98289

chr1_32086992_+

ENSG00000188603.19

ENST00000636147.1

CLN3-244

hsa-miR-5585-3p

chr16

28475509

28475515

7mer-m8

28475508

28475529

157

-19.87

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_291761

chr11_93733708_-

ENSG00000188603.19

ENST00000636147.1

CLN3-244

hsa-miR-1304-3p

chr16

28476615

28476621

7mer-m8

28476614

28476631

141

-13.52

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for CLN3

- RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000637100.1	protein_coding
ENST00000636147.1	protein_coding

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_532026	ENST00000637100.1	chr16_28474168_-	1227	-509.80	-510.50	-512.20
ADediting_532027	ENST00000637100.1	chr16_28474185_-	1210	-512.90	-510.50	-512.20
ADediting_532057	ENST00000636147.1	chr16_28475946_-	3237	-1559.20	-1553.80	-1614.40
ADediting_532058	ENST00000636147.1	chr16_28475951_-	3232	-1554.10	-1553.80	-1614.40
ADediting_532059	ENST00000636147.1	chr16_28475978_-	3205	-1558.00	-1553.80	-1614.40
ADediting_532060	ENST00000636147.1	chr16_28475982_-	3201	-1553.80	-1553.80	-1614.40
ADediting_532061	ENST00000636147.1	chr16_28475994_-	3189	-1553.30	-1553.80	-1614.40
ADediting_532062	ENST00000636147.1	chr16_28475995_-	3188	-1557.60	-1553.80	-1614.40
ADediting_532063	ENST00000636147.1	chr16_28476007_-	3176	-1553.80	-1553.80	-1614.40
ADediting_532064	ENST00000636147.1	chr16_28476014_-	3169	-1553.80	-1553.80	-1614.40
ADediting_532065	ENST00000636147.1	chr16_28476024_-	3159	-1553.40	-1553.80	-1614.40
ADediting_532066	ENST00000636147.1	chr16_28476046_-	3137	-1553.10	-1553.80	-1614.40
ADediting_532067	ENST00000636147.1	chr16_28476050_-	3133	-1553.50	-1553.80	-1614.40
ADediting_532068	ENST00000636147.1	chr16_28476053_-	3130	-1553.80	-1553.80	-1614.40
ADediting_532069	ENST00000636147.1	chr16_28476054_-	3129	-1553.90	-1553.80	-1614.40
ADediting_532070	ENST00000636147.1	chr16_28476055_-	3128	-1553.90	-1553.80	-1614.40
ADediting_1541823	ENST00000636147.1	chr16_28476060_-	3123	-1553.80	-1553.80	-1614.40
ADediting_1541824	ENST00000636147.1	chr16_28476063_-	3120	-1553.90	-1553.80	-1614.40
ADediting_532071	ENST00000636147.1	chr16_28476064_-	3119	-1553.90	-1553.80	-1614.40
ADediting_532072	ENST00000636147.1	chr16_28476069_-	3114	-1553.80	-1553.80	-1614.40
ADediting_532073	ENST00000636147.1	chr16_28476081_-	3102	-1553.90	-1553.80	-1614.40
ADediting_532074	ENST00000636147.1	chr16_28476090_-	3093	-1553.80	-1553.80	-1614.40
ADediting_532075	ENST00000636147.1	chr16_28476114_-	3069	-1553.10	-1553.80	-1614.40
ADediting_532076	ENST00000636147.1	chr16_28476119_-	3064	-1552.90	-1553.80	-1614.40
ADediting_532077	ENST00000636147.1	chr16_28476151_-	3032	-1553.40	-1553.80	-1614.40
ADediting_532078	ENST00000636147.1	chr16_28476159_-	3024	-1553.80	-1553.80	-1614.40
ADediting_532079	ENST00000636147.1	chr16_28476160_-	3023	-1553.90	-1553.80	-1614.40
ADediting_532080	ENST00000636147.1	chr16_28476166_-	3017	-1553.40	-1553.80	-1614.40
ADediting_532081	ENST00000636147.1	chr16_28476283_-	2900	-1554.00	-1553.80	-1614.40
ADediting_532082	ENST00000636147.1	chr16_28476286_-	2897	-1557.30	-1553.80	-1614.40
ADediting_532083	ENST00000636147.1	chr16_28476289_-	2894	-1556.50	-1553.80	-1614.40
ADediting_532084	ENST00000636147.1	chr16_28476298_-	2885	-1558.00	-1553.80	-1614.40
ADediting_532085	ENST00000636147.1	chr16_28476301_-	2882	-1560.40	-1553.80	-1614.40
ADediting_532086	ENST00000636147.1	chr16_28476302_-	2881	-1553.50	-1553.80	-1614.40
ADediting_532087	ENST00000636147.1	chr16_28476325_-	2858	-1553.80	-1553.80	-1614.40
ADediting_1541825	ENST00000636147.1	chr16_28476351_-	2832	-1554.60	-1553.80	-1614.40
ADediting_532088	ENST00000636147.1	chr16_28476355_-	2828	-1556.50	-1553.80	-1614.40
ADediting_1541826	ENST00000636147.1	chr16_28476402_-	2781	-1553.10	-1553.80	-1614.40
ADediting_532089	ENST00000636147.1	chr16_28476421_-	2762	-1554.50	-1553.80	-1614.40
ADediting_532090	ENST00000636147.1	chr16_28476434_-	2749	-1554.50	-1553.80	-1614.40
ADediting_532091	ENST00000636147.1	chr16_28476451_-	2732	-1554.10	-1553.80	-1614.40
ADediting_532092	ENST00000636147.1	chr16_28476453_-	2730	-1553.10	-1553.80	-1614.40
ADediting_532093	ENST00000636147.1	chr16_28476462_-	2721	-1553.80	-1553.80	-1614.40
ADediting_532094	ENST00000636147.1	chr16_28476463_-	2720	-1556.50	-1553.80	-1614.40
ADediting_532095	ENST00000636147.1	chr16_28476470_-	2713	-1554.40	-1553.80	-1614.40
ADediting_532096	ENST00000636147.1	chr16_28476510_-	2673	-1555.50	-1553.80	-1614.40
ADediting_532097	ENST00000636147.1	chr16_28476524_-	2659	-1553.50	-1553.80	-1614.40
ADediting_1541827	ENST00000636147.1	chr16_28476540_-	2643	-1553.10	-1553.80	-1614.40
ADediting_532098	ENST00000636147.1	chr16_28476546_-	2637	-1553.50	-1553.80	-1614.40
ADediting_532099	ENST00000636147.1	chr16_28476880_-	2303	-1553.80	-1553.80	-1614.40
ADediting_532100	ENST00000636147.1	chr16_28476885_-	2298	-1560.70	-1553.80	-1614.40
ADediting_532101	ENST00000636147.1	chr16_28476892_-	2291	-1553.50	-1553.80	-1614.40
ADediting_532102	ENST00000636147.1	chr16_28476907_-	2276	-1559.20	-1553.80	-1614.40
ADediting_532103	ENST00000636147.1	chr16_28476920_-	2263	-1553.10	-1553.80	-1614.40
ADediting_532104	ENST00000636147.1	chr16_28476932_-	2251	-1553.80	-1553.80	-1614.40
ADediting_532105	ENST00000636147.1	chr16_28476934_-	2249	-1553.50	-1553.80	-1614.40
ADediting_532106	ENST00000636147.1	chr16_28476974_-	2209	-1556.40	-1553.80	-1614.40
ADediting_532107	ENST00000636147.1	chr16_28476980_-	2203	-1553.80	-1553.80	-1614.40
ADediting_532108	ENST00000636147.1	chr16_28476982_-	2201	-1553.80	-1553.80	-1614.40
ADediting_1541828	ENST00000636147.1	chr16_28476988_-	2195	-1553.80	-1553.80	-1614.40
ADediting_532109	ENST00000636147.1	chr16_28476989_-	2194	-1553.90	-1553.80	-1614.40
ADediting_532110	ENST00000636147.1	chr16_28477037_-	2146	-1553.10	-1553.80	-1614.40
ADediting_532111	ENST00000636147.1	chr16_28477050_-	2133	-1553.80	-1553.80	-1614.40
ADediting_532112	ENST00000636147.1	chr16_28477054_-	2129	-1553.50	-1553.80	-1614.40
ADediting_532113	ENST00000636147.1	chr16_28477055_-	2128	-1553.50	-1553.80	-1614.40
ADediting_532114	ENST00000636147.1	chr16_28477067_-	2116	-1559.20	-1553.80	-1614.40
ADediting_532115	ENST00000636147.1	chr16_28477079_-	2104	-1553.40	-1553.80	-1614.40
ADediting_532116	ENST00000636147.1	chr16_28477097_-	2086	-1560.00	-1553.80	-1614.40
ADediting_532117	ENST00000636147.1	chr16_28477114_-	2069	-1557.40	-1553.80	-1614.40
ADediting_532118	ENST00000636147.1	chr16_28477122_-	2061	-1557.40	-1553.80	-1614.40
ADediting_532119	ENST00000636147.1	chr16_28477128_-	2055	-1552.90	-1553.80	-1614.40
ADediting_532120	ENST00000636147.1	chr16_28477130_-	2053	-1553.10	-1553.80	-1614.40

RNA A-to-I editing in lncRNA.

ADeditom_ID

ENST

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

Top

Relation with ADAR for CLN3

Correlation between ADAR gene expression and RNA editing frequency

Tissue	ADeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
CER	ADediting_532028	chr16_28474338_-	0.0342932683974807	0.172962384165199	5.93563155846841e-05	0.321781049611756	0.277056715418505	0.0893191774813017
CER	ADediting_532029	chr16_28474360_-	0.0509627644199135	0.159674985131478	5.33935619540947e-05	0.323668213026345	0.507338546038088	0.0545487050403262
CER	ADediting_532030	chr16_28474365_-	0.146607563950076	0.119098225005591	0.000165933773050963	0.302770152038351	0.103052170648201	0.133628196408216
CER	ADediting_532040	chr16_28474993_-	0.0981239769521247	0.135559835055517	4.55087829150212e-05	0.326493084784469	0.0384649410394022	0.169198727548144
DLPFC	ADediting_532046	chr16_28475057_-	0.328884005347539	0.0556355536353507	0.876985026068616	-0.00882710252393741	6.71114485509084e-08	0.300716227236114
DLPFC	ADediting_532056	chr16_28475214_-	0.00204021678164971	0.174535873611114	0.180970701072508	0.076177649621235	2.63229141483704e-11	0.366796972352448
DLPFC	ADediting_532066	chr16_28476046_-	0.797609750603012	0.0146232082767755	0.237003684184801	-0.0673578222301976	2.14545043311689e-08	0.311366717729616
DLPFC	ADediting_532078	chr16_28476159_-	0.338740319639162	0.0545142873126321	0.95325485961001	-0.00334288176634777	1.82916393091415e-09	0.33302429846371
DLPFC	ADediting_532079	chr16_28476160_-	0.691188837368663	0.0226504504600841	0.570890276848428	-0.0323108381802046	6.92532307686647e-09	0.32152652858051
DLPFC	ADediting_532080	chr16_28476166_-	0.307229038644399	0.0581778403196253	0.808465333629107	-0.0138229376185973	7.1386453533742e-12	0.376436055515544
DLPFC	ADediting_532081	chr16_28476283_-	0.038528027837287	0.117589255488302	0.550604511045786	0.0340267006393176	2.01293606959977e-13	0.401284854548068
CER	ADediting_532081	chr16_28476283_-	0.00100677508790759	0.265889242895299	5.12173150268945e-06	0.36258532132325	0.000510206308785165	0.280391869900882
DLPFC	ADediting_532082	chr16_28476286_-	0.0152084802044566	0.137764259225522	0.376744376877587	0.0503743787749285	6.96298499283843e-09	0.321478692077142
CER	ADediting_532082	chr16_28476286_-	0.0021833565610497	0.24832806470799	4.6444754685395e-06	0.364102417950449	0.00518613776206121	0.227139451926182
DLPFC	ADediting_532083	chr16_28476289_-	0.0118122709592121	0.142839012457018	0.295551147959687	0.0595979614843101	1.12267605756601e-08	0.317232150211084
CER	ADediting_532083	chr16_28476289_-	0.00027420403123984	0.292988621712479	1.0295296073355e-06	0.386548424171953	0.00150577396187444	0.25690656839986
DLPFC	ADediting_532084	chr16_28476298_-	0.124256506743717	0.0874902219426137	0.38211275137327	0.0498108404926347	2.04341084773376e-09	0.332085753242179
CER	ADediting_532084	chr16_28476298_-	0.00575428467245951	0.224465736477577	1.57381118361397e-06	0.380392904847778	0.0426956783358338	0.165717636681299
DLPFC	ADediting_532085	chr16_28476301_-	0.114356573270007	0.0898575999565709	0.30994109993339	0.0578531561103089	5.27685065625337e-09	0.323913684984332
CER	ADediting_532085	chr16_28476301_-	0.029030702337112	0.17830754881786	0.000112110035784788	0.310173552910244	0.000643646944946372	0.275523083449836
DLPFC	ADediting_532095	chr16_28476470_-	0.00509437230885994	0.158717941497222	0.198975053181728	0.0731511388304883	9.39298807818164e-12	0.374435172011462
CER	ADediting_532099	chr16_28476880_-	0.0018476673800615	0.252218060814974	4.66274508760949e-06	0.364041675748396	0.00287308648491221	0.24179808069783
CER	ADediting_532102	chr16_28476907_-	0.000721407968753288	0.273100048947839	9.78003055843025e-07	0.387284714159858	0.00882231337566408	0.213149357135568
CER	ADediting_532103	chr16_28476920_-	8.19237056058838e-06	0.355190204877044	3.44864316591034e-08	0.431791311788699	0.0184897489535875	0.192150510618453
DLPFC	ADediting_532108	chr16_28476982_-	0.460906991727413	0.0420301855320393	0.320563821239628	-0.0565990548713888	1.80102217116278e-13	0.40202692708993
CER	ADediting_532108	chr16_28476982_-	0.0790378868231583	0.14385753439662	0.00012162341576718	0.308651761009311	0.000928008959705265	0.267670036378714
CER	ADediting_532128	chr16_28478193_-	0.0589255213013913	0.154580542761995	6.888047020653e-05	0.319107046103755	0.0166741960173514	0.195202982162488
CER	ADediting_532132	chr16_28478229_-	0.0566580646604705	0.15597030271712	7.42325530524788e-05	0.317752880283967	0.00118995549329708	0.262196751013611
CER	ADediting_532137	chr16_28479008_-	0.0144526067736674	0.199358657060032	9.06559585059657e-06	0.353571111192058	0.027013877890963	0.180576952226627
CER	ADediting_532138	chr16_28479009_-	0.0453548548011614	0.163674924854864	1.54337768068546e-05	0.344916170961667	0.138895856292015	0.121402755928875
CER	ADediting_532139	chr16_28479011_-	0.0133937511383252	0.20153923343353	2.30951360055312e-07	0.407285333669028	0.0961012624560931	0.13637488851602
DLPFC	ADediting_532146	chr16_28479556_-	0.814230878674195	-0.0133990122254097	0.319100289316202	-0.0567702089417884	2.4419488535861e-08	0.310178915731416
CER	ADediting_532150	chr16_28479657_-	0.152967609907671	0.117265753721084	5.45580450073407e-05	0.323284637040074	0.00391908101765744	0.234201253350213
CER	ADediting_532153	chr16_28479693_-	0.038541022671464	0.169133348152623	3.67690953995967e-07	0.400983061985324	0.000832614357935542	0.270022556235929
DLPFC	ADediting_532155	chr16_28479735_-	0.0260629009361787	0.126390361436444	0.106224851329213	0.0919253570282003	1.94749252666001e-08	0.312251602781523
CER	ADediting_532156	chr16_28480026_-	0.0215976483869808	0.187481399283359	3.77867749655959e-05	0.329745815872268	0.0403728376093863	0.167591050824218
CER	ADediting_532160	chr16_28480089_-	0.167265002690997	0.11334633736029	2.77601056059824e-05	0.335060242068878	0.592798204853996	0.0440120650828131
CER	ADediting_532161	chr16_28480098_-	0.192532311371326	0.106988998980966	0.000163915917529477	0.303004159017091	0.109953313103885	0.131041866094348
CER	ADediting_532162	chr16_28480099_-	0.0903411727829388	0.138772915933985	2.2506896642472e-05	0.338620687237072	0.0128502220021804	0.202717775759471
CER	ADediting_532165	chr16_28480285_-	0.233680284818384	0.0978241189839546	6.23884241392252e-05	0.320888618840136	0.201345901983229	0.104915421144532
CER	ADediting_532168	chr16_28480349_-	0.191477766053094	0.107241688393509	0.00116816681616322	0.26260754211271	2.53895729831102e-06	0.373302371374956
CER	ADediting_532172	chr16_28480529_-	0.0344932611727224	0.172773356193527	1.18332583011006e-06	0.384542831800144	0.0543225486129564	0.157450532202866
CER	ADediting_532173	chr16_28480565_-	0.25299412567636	0.0939134927548251	0.000139114070537822	0.306123070924114	0.769519659237308	0.0241219253686819
CER	ADediting_532183	chr16_28481154_-	0.0144642846467449	0.199335396721862	1.34182571028633e-09	0.469608830859967	0.0013331202988038	0.259657055503704
CER	ADediting_532188	chr16_28481231_-	0.097920593768432	0.135641183974106	3.24930562363472e-06	0.369578534446206	0.0145719938954509	0.199121627519389
CER	ADediting_532189	chr16_28481238_-	0.108144263045609	0.131707243088611	1.8444327082641e-05	0.341959453000457	0.0570770964593609	0.155710065551526
CER	ADediting_532190	chr16_28481248_-	0.099528666227327	0.135001598894663	1.33475659338243e-05	0.347303873867017	0.0113347351999714	0.206251175344717
CER	ADediting_532194	chr16_28481274_-	0.0457411262422774	0.163386573579403	7.39207041126543e-06	0.356824455384455	0.112797667302762	0.130012805222559
DLPFC	ADediting_532197	chr16_28481333_-	0.234923640646794	0.0676568535316817	0.981824868616869	-0.00129912826187308	1.25476474877228e-11	0.372308991031641
CER	ADediting_532199	chr16_28481362_-	0.0644278712518163	0.151382167030071	4.49866294763394e-05	0.326696028685088	0.00700228737812196	0.219334534523822
DLPFC	ADediting_532204	chr16_28481775_-	0.0285548410623248	0.124378862997215	0.948895024019039	0.00365507339068514	4.88317757688014e-19	0.477231263663332
CER	ADediting_532204	chr16_28481775_-	0.127297636187878	0.125059980833739	1.19356540046715e-05	0.349128946213613	0.0451513662114684	0.163827653712094
DLPFC	ADediting_532226	chr16_28485038_-	0.104130880517605	0.0924779377010563	0.173849102072003	-0.0774361678678835	3.03219184953708e-25	0.543701718462994
DLPFC	ADediting_532251	chr16_28486094_-	0.130394708061112	-0.0860951312972578	0.00107390908149475	-0.184889874073405	2.67502023266711e-08	0.309339267862652
DLPFC	ADediting_532258	chr16_28486225_-	0.943119138642896	-0.00406883257312162	0.0184610579298416	-0.13376378769114	1.75321621724664e-12	0.386464245102722

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	4.01893336800562e-20	0.489944562878573	1.14807057833252e-18	0.472754840385363	1.43692977326704e-32	0.606823692089263
AC	2.47303576923152e-55	0.79315181256272	2.09557388087279e-34	0.673527523028394	1.03912076007522e-24	0.588693607432354
PCC	9.95160489527829e-11	0.446102078172569	6.84005773830124e-10	0.427607684761092	2.25750010378631e-07	0.364035538572961
CER	1.82507467700423e-07	0.410427012564579	3.42727790670251e-11	0.507428700811641	3.41043223462075e-06	0.368842491895483
TCX	6.42644524157043e-07	0.393240362726037	0.4812027049642	-0.0579479358802116	3.65929139647223e-33	0.789325393809299
FP	1.25831224874303e-09	0.435324571217343	4.65005666595326e-06	0.335638073592764	2.13470799050632e-15	0.548938058922201
IFG	0.00574807327273578	0.536014185456463	0.00870782474328184	0.513152753832129	7.13514782844206e-05	0.709525029955708
PG	0.128764453338239	0.111782114358658	0.0762564483016824	0.130314006367062	1.57926308191283e-09	0.424350686370038
STG	0.040046151283103	0.224525673530798	0.876856597700569	0.0171629280276502	2.66941213972703e-07	0.526612172608717

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Relation with AD stages for CLN3

Correlation between AD stages and RNA editing frequency

Tissue	ADeditomID	position	P-val	Coeff.
CER	ADediting_532026	chr16_28474168_-	0.000499450094234572	0.329398169439168
CER	ADediting_532028	chr16_28474338_-	0.000231127370984706	0.347277650045625
CER	ADediting_532039	chr16_28474990_-	3.19744806740486e-07	0.468340128801862
CER	ADediting_532040	chr16_28474993_-	1.71798365885247e-07	0.477673919695942
CER	ADediting_532041	chr16_28474999_-	3.79821084307229e-06	0.428136652719172
CER	ADediting_532043	chr16_28475006_-	0.000747341767676356	0.319598217840388
CER	ADediting_532045	chr16_28475053_-	2.51239597639309e-05	0.393553671884452
CER	ADediting_532047	chr16_28475095_-	0.000235193556264985	0.346884589570339
CER	ADediting_532083	chr16_28476289_-	0.000517707530077573	0.328538258242014
CER	ADediting_532084	chr16_28476298_-	0.000450511520748119	0.331854278318323
CER	ADediting_532101	chr16_28476892_-	0.00075045931242218	0.319495263720635
CER	ADediting_532103	chr16_28476920_-	0.00035836041951071	0.337233049962443
CER	ADediting_532109	chr16_28476989_-	0.0011940512066257	0.307774324747133
CER	ADediting_532150	chr16_28479657_-	6.16462040847526e-05	0.375669720491948
CER	ADediting_532153	chr16_28479693_-	9.80119133710245e-05	0.366007004792237
CER	ADediting_532168	chr16_28480349_-	0.000997804158897637	0.312362070670579

Correlation between AD stages and this gene's expression

Tissue	P-val	Coeff.
CER	5.10525936273166e-06	0.422969307495691
TCX	5.55066869815348e-08	0.498076753896837

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RelatedDrugs for CLN3

Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CLN3

Diseases associated with this gene. (DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CLN3	C0751383	Juvenile Neuronal Ceroid Lipofuscinosis	4	CTD_human;ORPHANET;UNIPROT
CLN3	C0024623	Malignant neoplasm of stomach	1	CTD_human
CLN3	C0038356	Stomach Neoplasms	1	CTD_human
CLN3	C0235874	Disease Exacerbation	1	CTD_human
CLN3	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human

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