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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for CLU |
 Gene summary |
| Gene information | Gene symbol | CLU | Gene ID | 1191 |
| Gene name | clusterin | |
| Synonyms | AAG4|APO-J|APOJ|CLI|CLU1|CLU2|KUB1|NA1/NA2|SGP-2|SGP2|SP-40|TRPM-2|TRPM2 | |
| Cytomap | 8p21.1 | |
| Type of gene | protein-coding | |
| Description | clusterinaging-associated protein 4apolipoprotein Jcomplement cytolysis inhibitorcomplement lysis inhibitorcomplement-associated protein SP-40,40epididymis secretory sperm binding proteinku70-binding protein 1sulfated glycoprotein 2testosterone-r | |
| Modification date | 20200327 | |
| UniProtAcc | P10909, | |
| Context | - 30090055(Clusterin Is Required for beta-Amyloid Toxicity in Human iPSC-Derived Neurons) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CLU | GO:0000902 | cell morphogenesis | 15857407 |
| CLU | GO:0001774 | microglial cell activation | 15857407 |
| CLU | GO:0017038 | protein import | 24446231 |
| CLU | GO:0031333 | negative regulation of protein complex assembly | 22179788|23106396 |
| CLU | GO:0031334 | positive regulation of protein complex assembly | 22179788 |
| CLU | GO:0032760 | positive regulation of tumor necrosis factor production | 15857407 |
| CLU | GO:0045429 | positive regulation of nitric oxide biosynthetic process | 15857407 |
| CLU | GO:0050821 | protein stabilization | 11123922|12176985 |
| CLU | GO:0051131 | chaperone-mediated protein complex assembly | 17412999 |
| CLU | GO:0051788 | response to misfolded protein | 19996109 |
| CLU | GO:0061077 | chaperone-mediated protein folding | 11123922 |
| CLU | GO:0061518 | microglial cell proliferation | 15857407 |
| CLU | GO:1900221 | regulation of amyloid-beta clearance | 24446231 |
| CLU | GO:1901214 | regulation of neuron death | 17412999 |
| CLU | GO:1901216 | positive regulation of neuron death | 15857407 |
| CLU | GO:1902430 | negative regulation of amyloid-beta formation | 12047389|17412999 |
| CLU | GO:1905907 | negative regulation of amyloid fibril formation | 22179788 |
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RNA A-to-I events for CLU |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1399301(27600277, -), ADediting_1399302(27600318, -), ADediting_1399303(27600319, -), ADediting_1399304(27600323, -), ADediting_1399305(27600332, -), ADediting_1399306(27600338, -), ADediting_1399307(27600359, -), ADediting_1399308(27600373, -), ADediting_1399309(27600375, -), ADediting_1399310(27600386, -), ADediting_1399311(27600391, -), ADediting_1399312(27600399, -), ADediting_1399313(27600403, -), ADediting_1399314(27600404, -), ADediting_1399315(27600408, -), ADediting_1399316(27600410, -), ADediting_1399317(27600411, -), ADediting_1399318(27600412, -), ADediting_1399319(27600413, -), ADediting_1399320(27600414, -), ADediting_1399321(27600415, -), ADediting_1399322(27600417, -), ADediting_1399323(27600434, -), ADediting_1399324(27600448, -), ADediting_1399325(27600459, -), ADediting_1399326(27600462, -), ADediting_1399327(27600524, -), ADediting_1399328(27601121, -), ADediting_1399329(27601145, -), ADediting_1399330(27601146, -), ADediting_1399331(27601154, -), ADediting_1399332(27601177, -), ADediting_1399333(27601180, -), ADediting_1399334(27601181, -), ADediting_1399335(27601186, -), ADediting_1399336(27601187, -), ADediting_1399337(27601197, -), ADediting_1399338(27601218, -), ADediting_1399339(27601219, -), ADediting_1399340(27601229, -), ADediting_1399341(27601244, -), ADediting_1399342(27601245, -), ADediting_1399343(27601252, -), ADediting_1399344(27601254, -), ADediting_1399345(27601259, -), ADediting_1399346(27601278, -), ADediting_1399347(27601322, -), ADediting_1399348(27601323, -), ADediting_1399349(27601846, -), ADediting_1399350(27601856, -), ADediting_1399351(27601899, -), ADediting_1399352(27601906, -), ADediting_1399353(27601936, -), ADediting_1399354(27602008, -), ADediting_1399355(27602028, -), ADediting_1399356(27602045, -), ADediting_1399357(27602090, -), ADediting_1399358(27602360, -), ADediting_1399359(27602368, -), ADediting_1399360(27602385, -), ADediting_1399361(27602386, -), ADediting_1399362(27602410, -), ADediting_1399363(27602411, -), ADediting_1399364(27602418, -), ADediting_1399365(27602440, -), ADediting_1399366(27602481, -), ADediting_1399367(27602582, -), ADediting_1399368(27602820, -), ADediting_1399369(27602847, -), ADediting_1399370(27602873, -), ADediting_1399371(27602882, -), ADediting_1399372(27602893, -), ADediting_1399373(27602899, -), ADediting_1399374(27602902, -), ADediting_1399375(27602917, -), ADediting_1399376(27602953, -), ADediting_1399377(27602956, -), ADediting_1399378(27602978, -), ADediting_1399379(27602982, -), ADediting_1399380(27602983, -), ADediting_1399381(27603029, -), ADediting_1590346(27601317, -), ADediting_1590347(27602004, -), ADediting_1590348(27602034, -), ADediting_1590349(27613345, -), |
Top |
RNA editing positional annotations for CLU using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1399301 | chr8_27600277_- | intronic |
| ADediting_1399302 | chr8_27600318_- | intronic |
| ADediting_1399303 | chr8_27600319_- | intronic |
| ADediting_1399304 | chr8_27600323_- | intronic |
| ADediting_1399305 | chr8_27600332_- | intronic |
| ADediting_1399306 | chr8_27600338_- | intronic |
| ADediting_1399307 | chr8_27600359_- | intronic |
| ADediting_1399308 | chr8_27600373_- | intronic |
| ADediting_1399309 | chr8_27600375_- | intronic |
| ADediting_1399310 | chr8_27600386_- | intronic |
| ADediting_1399311 | chr8_27600391_- | intronic |
| ADediting_1399312 | chr8_27600399_- | intronic |
| ADediting_1399313 | chr8_27600403_- | intronic |
| ADediting_1399314 | chr8_27600404_- | intronic |
| ADediting_1399315 | chr8_27600408_- | intronic |
| ADediting_1399316 | chr8_27600410_- | intronic |
| ADediting_1399317 | chr8_27600411_- | intronic |
| ADediting_1399318 | chr8_27600412_- | intronic |
| ADediting_1399319 | chr8_27600413_- | intronic |
| ADediting_1399320 | chr8_27600414_- | intronic |
| ADediting_1399321 | chr8_27600415_- | intronic |
| ADediting_1399322 | chr8_27600417_- | intronic |
| ADediting_1399323 | chr8_27600434_- | intronic |
| ADediting_1399324 | chr8_27600448_- | intronic |
| ADediting_1399325 | chr8_27600459_- | intronic |
| ADediting_1399326 | chr8_27600462_- | intronic |
| ADediting_1399327 | chr8_27600524_- | intronic |
| ADediting_1399328 | chr8_27601121_- | intronic |
| ADediting_1399329 | chr8_27601145_- | intronic |
| ADediting_1399330 | chr8_27601146_- | intronic |
| ADediting_1399331 | chr8_27601154_- | intronic |
| ADediting_1399332 | chr8_27601177_- | intronic |
| ADediting_1399333 | chr8_27601180_- | intronic |
| ADediting_1399334 | chr8_27601181_- | intronic |
| ADediting_1399335 | chr8_27601186_- | intronic |
| ADediting_1399336 | chr8_27601187_- | intronic |
| ADediting_1399337 | chr8_27601197_- | intronic |
| ADediting_1399338 | chr8_27601218_- | intronic |
| ADediting_1399339 | chr8_27601219_- | intronic |
| ADediting_1399340 | chr8_27601229_- | intronic |
| ADediting_1399341 | chr8_27601244_- | intronic |
| ADediting_1399342 | chr8_27601245_- | intronic |
| ADediting_1399343 | chr8_27601252_- | intronic |
| ADediting_1399344 | chr8_27601254_- | intronic |
| ADediting_1399345 | chr8_27601259_- | intronic |
| ADediting_1399346 | chr8_27601278_- | intronic |
| ADediting_1399347 | chr8_27601322_- | intronic |
| ADediting_1399348 | chr8_27601323_- | intronic |
| ADediting_1399349 | chr8_27601846_- | intronic |
| ADediting_1399350 | chr8_27601856_- | intronic |
| ADediting_1399351 | chr8_27601899_- | intronic |
| ADediting_1399352 | chr8_27601906_- | intronic |
| ADediting_1399353 | chr8_27601936_- | intronic |
| ADediting_1399354 | chr8_27602008_- | intronic |
| ADediting_1399355 | chr8_27602028_- | intronic |
| ADediting_1399356 | chr8_27602045_- | intronic |
| ADediting_1399357 | chr8_27602090_- | intronic |
| ADediting_1399358 | chr8_27602360_- | intronic |
| ADediting_1399359 | chr8_27602368_- | intronic |
| ADediting_1399360 | chr8_27602385_- | intronic |
| ADediting_1399361 | chr8_27602386_- | intronic |
| ADediting_1399362 | chr8_27602410_- | intronic |
| ADediting_1399363 | chr8_27602411_- | intronic |
| ADediting_1399364 | chr8_27602418_- | intronic |
| ADediting_1399365 | chr8_27602440_- | intronic |
| ADediting_1399366 | chr8_27602481_- | intronic |
| ADediting_1399367 | chr8_27602582_- | intronic |
| ADediting_1399368 | chr8_27602820_- | intronic |
| ADediting_1399369 | chr8_27602847_- | intronic |
| ADediting_1399370 | chr8_27602873_- | intronic |
| ADediting_1399371 | chr8_27602882_- | intronic |
| ADediting_1399372 | chr8_27602893_- | intronic |
| ADediting_1399373 | chr8_27602899_- | intronic |
| ADediting_1399374 | chr8_27602902_- | intronic |
| ADediting_1399375 | chr8_27602917_- | intronic |
| ADediting_1399376 | chr8_27602953_- | intronic |
| ADediting_1399377 | chr8_27602956_- | intronic |
| ADediting_1399378 | chr8_27602978_- | intronic |
| ADediting_1399379 | chr8_27602982_- | intronic |
| ADediting_1399380 | chr8_27602983_- | intronic |
| ADediting_1399381 | chr8_27603029_- | intronic |
| ADediting_1590346 | chr8_27601317_- | intronic |
| ADediting_1590347 | chr8_27602004_- | intronic |
| ADediting_1590348 | chr8_27602034_- | intronic |
| ADediting_1590349 | chr8_27613345_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1399301 | chr8_27600277_- | SINE | Alu | Name=AluJb |
| ADediting_1399302 | chr8_27600318_- | SINE | Alu | Name=AluJb |
| ADediting_1399303 | chr8_27600319_- | SINE | Alu | Name=AluJb |
| ADediting_1399304 | chr8_27600323_- | SINE | Alu | Name=AluJb |
| ADediting_1399305 | chr8_27600332_- | SINE | Alu | Name=AluJb |
| ADediting_1399306 | chr8_27600338_- | SINE | Alu | Name=AluJb |
| ADediting_1399307 | chr8_27600359_- | SINE | Alu | Name=AluJb |
| ADediting_1399308 | chr8_27600373_- | SINE | Alu | Name=AluJb |
| ADediting_1399309 | chr8_27600375_- | SINE | Alu | Name=AluJb |
| ADediting_1399310 | chr8_27600386_- | SINE | Alu | Name=AluJb |
| ADediting_1399311 | chr8_27600391_- | SINE | Alu | Name=AluJb |
| ADediting_1399312 | chr8_27600399_- | SINE | Alu | Name=AluJb |
| ADediting_1399313 | chr8_27600403_- | SINE | Alu | Name=AluJb |
| ADediting_1399314 | chr8_27600404_- | SINE | Alu | Name=AluJb |
| ADediting_1399315 | chr8_27600408_- | SINE | Alu | Name=AluJb |
| ADediting_1399316 | chr8_27600410_- | SINE | Alu | Name=AluJb |
| ADediting_1399317 | chr8_27600411_- | SINE | Alu | Name=AluJb |
| ADediting_1399318 | chr8_27600412_- | SINE | Alu | Name=AluJb |
| ADediting_1399319 | chr8_27600413_- | SINE | Alu | Name=AluJb |
| ADediting_1399320 | chr8_27600414_- | SINE | Alu | Name=AluJb |
| ADediting_1399321 | chr8_27600415_- | SINE | Alu | Name=AluJb |
| ADediting_1399322 | chr8_27600417_- | SINE | Alu | Name=AluJb |
| ADediting_1399323 | chr8_27600434_- | SINE | Alu | Name=AluJb |
| ADediting_1399324 | chr8_27600448_- | SINE | Alu | Name=AluJb |
| ADediting_1399325 | chr8_27600459_- | SINE | Alu | Name=AluJb |
| ADediting_1399326 | chr8_27600462_- | SINE | Alu | Name=AluJb |
| ADediting_1399327 | chr8_27600524_- | DNA | hAT-Charlie | Name=Charlie10b |
| ADediting_1399328 | chr8_27601121_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399329 | chr8_27601145_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399330 | chr8_27601146_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399331 | chr8_27601154_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399332 | chr8_27601177_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399333 | chr8_27601180_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399334 | chr8_27601181_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399335 | chr8_27601186_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399336 | chr8_27601187_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399337 | chr8_27601197_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399338 | chr8_27601218_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399339 | chr8_27601219_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399340 | chr8_27601229_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399341 | chr8_27601244_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399342 | chr8_27601245_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399343 | chr8_27601252_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399344 | chr8_27601254_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399345 | chr8_27601259_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399346 | chr8_27601278_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399347 | chr8_27601322_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399348 | chr8_27601323_- | SINE | Alu | Name=AluSq2 |
| ADediting_1399349 | chr8_27601846_- | SINE | Alu | Name=AluSz |
| ADediting_1399350 | chr8_27601856_- | SINE | Alu | Name=AluSz |
| ADediting_1399351 | chr8_27601899_- | SINE | Alu | Name=AluSz |
| ADediting_1399352 | chr8_27601906_- | SINE | Alu | Name=AluSz |
| ADediting_1399353 | chr8_27601936_- | SINE | Alu | Name=AluSz |
| ADediting_1399354 | chr8_27602008_- | SINE | Alu | Name=AluSz |
| ADediting_1399355 | chr8_27602028_- | SINE | Alu | Name=AluSz |
| ADediting_1399356 | chr8_27602045_- | SINE | Alu | Name=AluSz |
| ADediting_1399357 | chr8_27602090_- | SINE | Alu | Name=AluSz |
| ADediting_1399358 | chr8_27602360_- | SINE | Alu | Name=AluJo |
| ADediting_1399359 | chr8_27602368_- | SINE | Alu | Name=AluJo |
| ADediting_1399360 | chr8_27602385_- | SINE | Alu | Name=AluJo |
| ADediting_1399361 | chr8_27602386_- | SINE | Alu | Name=AluJo |
| ADediting_1399362 | chr8_27602410_- | SINE | Alu | Name=AluJo |
| ADediting_1399363 | chr8_27602411_- | SINE | Alu | Name=AluJo |
| ADediting_1399364 | chr8_27602418_- | SINE | Alu | Name=AluJo |
| ADediting_1399365 | chr8_27602440_- | SINE | Alu | Name=AluJo |
| ADediting_1399366 | chr8_27602481_- | SINE | Alu | Name=AluJo |
| ADediting_1399367 | chr8_27602582_- | SINE | Alu | Name=AluJo |
| ADediting_1399368 | chr8_27602820_- | SINE | Alu | Name=AluSz |
| ADediting_1399369 | chr8_27602847_- | SINE | Alu | Name=AluSz |
| ADediting_1399370 | chr8_27602873_- | SINE | Alu | Name=AluSz |
| ADediting_1399371 | chr8_27602882_- | SINE | Alu | Name=AluSz |
| ADediting_1399372 | chr8_27602893_- | SINE | Alu | Name=AluSz |
| ADediting_1399373 | chr8_27602899_- | SINE | Alu | Name=AluSz |
| ADediting_1399374 | chr8_27602902_- | SINE | Alu | Name=AluSz |
| ADediting_1399375 | chr8_27602917_- | SINE | Alu | Name=AluSz |
| ADediting_1399376 | chr8_27602953_- | SINE | Alu | Name=AluSz |
| ADediting_1399377 | chr8_27602956_- | SINE | Alu | Name=AluSz |
| ADediting_1399378 | chr8_27602978_- | SINE | Alu | Name=AluSz |
| ADediting_1399379 | chr8_27602982_- | SINE | Alu | Name=AluSz |
| ADediting_1399380 | chr8_27602983_- | SINE | Alu | Name=AluSz |
| ADediting_1399381 | chr8_27603029_- | SINE | Alu | Name=AluSz |
| ADediting_1590346 | chr8_27601317_- | SINE | Alu | Name=AluSq2 |
| ADediting_1590347 | chr8_27602004_- | SINE | Alu | Name=AluSz |
| ADediting_1590348 | chr8_27602034_- | SINE | Alu | Name=AluSz |
| ADediting_1590349 | chr8_27613345_- | SINE | Alu | Name=AluSz |
Top |
RNA A-to-I editing events in the alternative splicing sites for CLU |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CLU |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
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| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for CLU |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for CLU |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_496066 | chr15_66496985_- | ENSG00000120885.22 | ENST00000316403.15 | CLU-201 | hsa-miR-4512 | chr8 | 27598118 | 27598124 | 7mer-m8 | 27598117 | 27598138 | 140 | -19.64 |
| ADediting_496066 | chr15_66496985_- | ENSG00000120885.22 | ENST00000316403.15 | CLU-201 | hsa-miR-4512 | chr8 | 27598131 | 27598138 | 8mer-1a | 27598117 | 27598138 | 140 | -19.64 |
| ADediting_496066 | chr15_66496985_- | ENSG00000120885.22 | ENST00000316403.15 | CLU-201 | hsa-miR-4512 | chr8 | 27598131 | 27598138 | 8mer-1a | 27598131 | 27598152 | 142 | -15.31 |
| ADediting_496066 | chr15_66496985_- | ENSG00000120885.22 | ENST00000405140.7 | CLU-202 | hsa-miR-4512 | chr8 | 27598118 | 27598124 | 7mer-m8 | 27598117 | 27598138 | 140 | -19.64 |
| ADediting_496066 | chr15_66496985_- | ENSG00000120885.22 | ENST00000405140.7 | CLU-202 | hsa-miR-4512 | chr8 | 27598131 | 27598138 | 8mer-1a | 27598117 | 27598138 | 140 | -19.64 |
| ADediting_496066 | chr15_66496985_- | ENSG00000120885.22 | ENST00000405140.7 | CLU-202 | hsa-miR-4512 | chr8 | 27598131 | 27598138 | 8mer-1a | 27598131 | 27598152 | 142 | -15.31 |
| ADediting_496066 | chr15_66496985_- | ENSG00000120885.22 | ENST00000523500.5 | CLU-215 | hsa-miR-4512 | chr8 | 27598118 | 27598124 | 7mer-m8 | 27598117 | 27598138 | 140 | -19.64 |
| ADediting_496066 | chr15_66496985_- | ENSG00000120885.22 | ENST00000523500.5 | CLU-215 | hsa-miR-4512 | chr8 | 27598131 | 27598138 | 8mer-1a | 27598117 | 27598138 | 140 | -19.64 |
| ADediting_496066 | chr15_66496985_- | ENSG00000120885.22 | ENST00000523500.5 | CLU-215 | hsa-miR-4512 | chr8 | 27598131 | 27598138 | 8mer-1a | 27598131 | 27598152 | 142 | -15.31 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for CLU |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for CLU |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1399306 | chr8_27600338_- | 0.00312740843358509 | 0.239745666738662 | 0.000161222969715806 | 0.303320669730196 | 0.936447297332869 | 0.00656526138551468 |
| DLPFC | ADediting_1399333 | chr8_27601180_- | 1.61180824153727e-08 | 0.3139725658017 | 2.23464210947955e-06 | 0.264953262996973 | 0.000373129040717017 | 0.200851254637008 |
| CER | ADediting_1399345 | chr8_27601259_- | 9.23112996685539e-05 | 0.31377120175499 | 4.06381296437825e-05 | 0.328477633014126 | 0.000222185737044981 | 0.297127461113392 |
| DLPFC | ADediting_1399349 | chr8_27601846_- | 0.00699790554905939 | 0.152892182466967 | 0.599060176630821 | 0.0299751170681897 | 3.34148001953961e-15 | 0.427479281071505 |
| DLPFC | ADediting_1399350 | chr8_27601856_- | 0.017329785747153 | 0.135079879754446 | 0.909982438508614 | -0.00644739498119673 | 3.99858400002332e-18 | 0.46610047666814 |
| CER | ADediting_1399352 | chr8_27601906_- | 0.0192060893040677 | 0.191017283751898 | 0.00089342227120538 | 0.268496187323135 | 5.98153883329903e-05 | 0.321643225288153 |
| CER | ADediting_1399371 | chr8_27602882_- | 0.0220779877364192 | 0.186812288010694 | 0.00165646314849095 | 0.254731786906581 | 1.42461208541013e-05 | 0.346235107102823 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.72417391990847e-39 | 0.655788413384195 | 6.14432865573981e-23 | 0.520666918283803 | 3.22010469245845e-09 | 0.328198380026152 |
| AC | 6.69342610857758e-41 | 0.717966586981328 | 3.99843970846381e-19 | 0.525167866627196 | 7.06718487376416e-28 | 0.619384879446075 |
| PCC | 1.3718946394765e-15 | 0.535857564476832 | 2.51705596521603e-10 | 0.437338009242256 | 4.37694064782596e-06 | 0.325360189338081 |
| CER | 2.50376116283677e-06 | 0.373511717930416 | 0.00038987061091627 | 0.28592092710322 | 6.62415100383483e-19 | 0.643524634145748 |
| TCX | 1.23622802489542e-12 | 0.538093597069579 | 0.0172231203598933 | 0.194250844336926 | 7.10181323722562e-05 | 0.318554749806954 |
| FP | 1.12312622690277e-06 | 0.355443611305211 | 0.713022747081124 | -0.0277579865753909 | 0.000109879351767055 | 0.28583630144408 |
| IFG | 5.70809443554871e-07 | 0.818596180197487 | 0.000644681970178898 | 0.635282420838334 | 0.0886239495760196 | 0.347623236065169 |
| PG | 5.47818302600941e-21 | 0.618142278799574 | 1.83559878304535e-05 | 0.308501933745269 | 2.07865958119576e-05 | 0.306602063226327 |
| STG | 8.64208975989451e-05 | 0.415072853062539 | 0.661497170737994 | 0.0484712170524981 | 0.0775086033433663 | 0.193686842271246 |
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Relation with AD stages for CLU |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| TCX | ADediting_1399345 | chr8_27601259_- | 0.000486407682552374 | 0.333021445276526 |
| TCX | ADediting_1399379 | chr8_27602982_- | 0.000358738774145733 | 0.340256121929627 |
| IFG | ADediting_1399345 | chr8_27601259_- | 0.0112614191895443 | 0.498187153213234 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 4.53471554299653e-05 | 0.381905178114864 |
| TCX | 2.53851192851703e-09 | 0.538873728449776 |
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RelatedDrugs for CLU |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| CLU | P10909 | DB01593 | Zinc | Clusterin | small molecule | approved|investigational |
| CLU | P10909 | DB14487 | Zinc acetate | Clusterin | small molecule | approved|investigational |
| CLU | P10909 | DB14533 | Zinc chloride | Clusterin | small molecule | approved|investigational |
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RelatedDiseases for CLU |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| CLU | C0022660 | Kidney Failure, Acute | 6 | CTD_human |
| CLU | C1565662 | Acute Kidney Insufficiency | 6 | CTD_human |
| CLU | C2609414 | Acute kidney injury | 6 | CTD_human |
| CLU | C0002395 | Alzheimer's Disease | 3 | CTD_human |
| CLU | C0011265 | Presenile dementia | 3 | CTD_human |
| CLU | C0022658 | Kidney Diseases | 3 | CTD_human |
| CLU | C0276496 | Familial Alzheimer Disease (FAD) | 3 | CTD_human |
| CLU | C0494463 | Alzheimer Disease, Late Onset | 3 | CTD_human |
| CLU | C0546126 | Acute Confusional Senile Dementia | 3 | CTD_human |
| CLU | C0750900 | Alzheimer's Disease, Focal Onset | 3 | CTD_human |
| CLU | C0750901 | Alzheimer Disease, Early Onset | 3 | CTD_human |
| CLU | C0013221 | Drug toxicity | 2 | CTD_human |
| CLU | C0029408 | Degenerative polyarthritis | 2 | CTD_human |
| CLU | C0041755 | Adverse reaction to drug | 2 | CTD_human |
| CLU | C0086743 | Osteoarthrosis Deformans | 2 | CTD_human |
| CLU | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
| CLU | C0022333 | Jacksonian Seizure | 1 | CTD_human |
| CLU | C0024141 | Lupus Erythematosus, Systemic | 1 | CTD_human |
| CLU | C0025202 | melanoma | 1 | CTD_human |
| CLU | C0027686 | Pathologic Neovascularization | 1 | CTD_human |
| CLU | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| CLU | C0036341 | Schizophrenia | 1 | PSYGENET |
| CLU | C0036572 | Seizures | 1 | CTD_human |
| CLU | C0087031 | Juvenile-Onset Still Disease | 1 | CTD_human |
| CLU | C0149958 | Complex partial seizures | 1 | CTD_human |
| CLU | C0234533 | Generalized seizures | 1 | CTD_human |
| CLU | C0234535 | Seizures, Clonic | 1 | CTD_human |
| CLU | C0242380 | Libman-Sacks Disease | 1 | CTD_human |
| CLU | C0270824 | Visual seizure | 1 | CTD_human |
| CLU | C0270844 | Tonic Seizures | 1 | CTD_human |
| CLU | C0270846 | Epileptic drop attack | 1 | CTD_human |
| CLU | C0333641 | Atrophic | 1 | CTD_human |
| CLU | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| CLU | C0422850 | Seizures, Somatosensory | 1 | CTD_human |
| CLU | C0422852 | Seizures, Auditory | 1 | CTD_human |
| CLU | C0422853 | Olfactory seizure | 1 | CTD_human |
| CLU | C0422854 | Gustatory seizure | 1 | CTD_human |
| CLU | C0422855 | Vertiginous seizure | 1 | CTD_human |
| CLU | C0494475 | Tonic - clonic seizures | 1 | CTD_human |
| CLU | C0751056 | Non-epileptic convulsion | 1 | CTD_human |
| CLU | C0751110 | Single Seizure | 1 | CTD_human |
| CLU | C0751123 | Atonic Absence Seizures | 1 | CTD_human |
| CLU | C0751494 | Convulsive Seizures | 1 | CTD_human |
| CLU | C0751495 | Seizures, Focal | 1 | CTD_human |
| CLU | C0751496 | Seizures, Sensory | 1 | CTD_human |
| CLU | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
| CLU | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
| CLU | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
| CLU | C1862941 | Amyotrophic Lateral Sclerosis, Sporadic | 1 | CTD_human |
| CLU | C3495559 | Juvenile arthritis | 1 | CTD_human |
| CLU | C3495874 | Nonepileptic Seizures | 1 | CTD_human |
| CLU | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
| CLU | C3714758 | Juvenile psoriatic arthritis | 1 | CTD_human |
| CLU | C4048158 | Convulsions | 1 | CTD_human |
| CLU | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| CLU | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
| CLU | C4316903 | Absence Seizures | 1 | CTD_human |
| CLU | C4317109 | Epileptic Seizures | 1 | CTD_human |
| CLU | C4317123 | Myoclonic Seizures | 1 | CTD_human |
| CLU | C4505436 | Generalized Absence Seizures | 1 | CTD_human |
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