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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for TOP1MT |
 Gene summary |
| Gene information | Gene symbol | TOP1MT | Gene ID | 116447 |
| Gene name | DNA topoisomerase I mitochondrial | |
| Synonyms | - | |
| Cytomap | 8q24.3 | |
| Type of gene | protein-coding | |
| Description | DNA topoisomerase I, mitochondrialmitochondrial topoisomerase IBtopoisomerase (DNA) I, mitochondrial | |
| Modification date | 20200313 | |
| UniProtAcc | Q969P6, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for TOP1MT |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1392424(143305983, -), ADediting_1392425(143311011, -), ADediting_1392426(143311026, -), ADediting_1392427(143311044, -), ADediting_1392428(143311091, -), ADediting_1392429(143311099, -), ADediting_1392430(143311101, -), ADediting_1392431(143311164, -), ADediting_1392432(143311172, -), ADediting_1392433(143311173, -), ADediting_1392434(143311211, -), ADediting_1392435(143311215, -), ADediting_1392436(143311224, -), ADediting_1392437(143311235, -), ADediting_1392438(143311236, -), ADediting_1392439(143311241, -), ADediting_1392440(143311242, -), ADediting_1392441(143311259, -), ADediting_1392442(143311491, -), ADediting_1392443(143311558, -), ADediting_1392444(143311563, -), ADediting_1392445(143311566, -), ADediting_1392446(143311583, -), ADediting_1392447(143311622, -), ADediting_1392448(143311624, -), ADediting_1392449(143311634, -), ADediting_1392450(143311694, -), ADediting_1392451(143311742, -), ADediting_1392452(143312865, -), ADediting_1392453(143314427, -), ADediting_1392454(143314482, -), ADediting_1392455(143319891, -), ADediting_1392456(143319952, -), ADediting_1392457(143320088, -), |
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RNA editing positional annotations for TOP1MT using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1392424 | chr8_143305983_- | intronic |
| ADediting_1392425 | chr8_143311011_- | intronic |
| ADediting_1392426 | chr8_143311026_- | intronic |
| ADediting_1392427 | chr8_143311044_- | intronic |
| ADediting_1392428 | chr8_143311091_- | intronic |
| ADediting_1392429 | chr8_143311099_- | intronic |
| ADediting_1392430 | chr8_143311101_- | intronic |
| ADediting_1392431 | chr8_143311164_- | intronic |
| ADediting_1392432 | chr8_143311172_- | intronic |
| ADediting_1392433 | chr8_143311173_- | intronic |
| ADediting_1392434 | chr8_143311211_- | intronic |
| ADediting_1392435 | chr8_143311215_- | intronic |
| ADediting_1392436 | chr8_143311224_- | intronic |
| ADediting_1392437 | chr8_143311235_- | intronic |
| ADediting_1392438 | chr8_143311236_- | intronic |
| ADediting_1392439 | chr8_143311241_- | intronic |
| ADediting_1392440 | chr8_143311242_- | intronic |
| ADediting_1392441 | chr8_143311259_- | intronic |
| ADediting_1392442 | chr8_143311491_- | intronic |
| ADediting_1392443 | chr8_143311558_- | intronic |
| ADediting_1392444 | chr8_143311563_- | intronic |
| ADediting_1392445 | chr8_143311566_- | intronic |
| ADediting_1392446 | chr8_143311583_- | intronic |
| ADediting_1392447 | chr8_143311622_- | intronic |
| ADediting_1392448 | chr8_143311624_- | intronic |
| ADediting_1392449 | chr8_143311634_- | intronic |
| ADediting_1392450 | chr8_143311694_- | intronic |
| ADediting_1392451 | chr8_143311742_- | intronic |
| ADediting_1392452 | chr8_143312865_- | intronic |
| ADediting_1392453 | chr8_143314427_- | intronic |
| ADediting_1392454 | chr8_143314482_- | intronic |
| ADediting_1392455 | chr8_143319891_- | intronic |
| ADediting_1392456 | chr8_143319952_- | intronic |
| ADediting_1392457 | chr8_143320088_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1392424 | chr8_143305983_- | SINE | Alu | Name=AluSq2 |
| ADediting_1392425 | chr8_143311011_- | SINE | Alu | Name=AluSz |
| ADediting_1392426 | chr8_143311026_- | SINE | Alu | Name=AluSz |
| ADediting_1392427 | chr8_143311044_- | SINE | Alu | Name=AluSz |
| ADediting_1392428 | chr8_143311091_- | SINE | Alu | Name=AluSz |
| ADediting_1392429 | chr8_143311099_- | SINE | Alu | Name=AluSz |
| ADediting_1392430 | chr8_143311101_- | SINE | Alu | Name=AluSz |
| ADediting_1392431 | chr8_143311164_- | SINE | Alu | Name=AluSz |
| ADediting_1392432 | chr8_143311172_- | SINE | Alu | Name=AluSz |
| ADediting_1392433 | chr8_143311173_- | SINE | Alu | Name=AluSz |
| ADediting_1392434 | chr8_143311211_- | SINE | Alu | Name=AluSz |
| ADediting_1392435 | chr8_143311215_- | SINE | Alu | Name=AluSz |
| ADediting_1392436 | chr8_143311224_- | SINE | Alu | Name=AluSz |
| ADediting_1392437 | chr8_143311235_- | SINE | Alu | Name=AluSz |
| ADediting_1392438 | chr8_143311236_- | SINE | Alu | Name=AluSz |
| ADediting_1392439 | chr8_143311241_- | SINE | Alu | Name=AluSz |
| ADediting_1392440 | chr8_143311242_- | SINE | Alu | Name=AluSz |
| ADediting_1392441 | chr8_143311259_- | SINE | Alu | Name=AluSz |
| ADediting_1392442 | chr8_143311491_- | SINE | Alu | Name=AluSg |
| ADediting_1392443 | chr8_143311558_- | SINE | Alu | Name=AluSg |
| ADediting_1392444 | chr8_143311563_- | SINE | Alu | Name=AluSg |
| ADediting_1392445 | chr8_143311566_- | SINE | Alu | Name=AluSg |
| ADediting_1392446 | chr8_143311583_- | SINE | Alu | Name=AluSg |
| ADediting_1392447 | chr8_143311622_- | SINE | Alu | Name=AluSg |
| ADediting_1392448 | chr8_143311624_- | SINE | Alu | Name=AluSg |
| ADediting_1392449 | chr8_143311634_- | SINE | Alu | Name=AluSg |
| ADediting_1392450 | chr8_143311694_- | SINE | Alu | Name=AluSg |
| ADediting_1392451 | chr8_143311742_- | SINE | Alu | Name=AluSg |
| ADediting_1392452 | chr8_143312865_- | SINE | Alu | Name=AluJr |
| ADediting_1392453 | chr8_143314427_- | SINE | Alu | Name=AluSz |
| ADediting_1392454 | chr8_143314482_- | SINE | Alu | Name=AluSz |
| ADediting_1392455 | chr8_143319891_- | SINE | Alu | Name=AluSg |
| ADediting_1392456 | chr8_143319952_- | SINE | Alu | Name=AluSg |
| ADediting_1392457 | chr8_143320088_- | SINE | Alu | Name=AluSg |
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RNA A-to-I editing events in the alternative splicing sites for TOP1MT |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TOP1MT |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for TOP1MT |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for TOP1MT |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_496066 | chr15_66496985_- | ENSG00000184428.13 | ENST00000519977.5 | TOP1MT-210 | hsa-miR-4512 | chr8 | 143304758 | 143304765 | 8mer-1a | 143304758 | 143304777 | 141 | -17.7 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_527135 | chr16_24203190_+ | ENSG00000184428.13 | ENST00000519977.5 | TOP1MT-210 | hsa-miR-1273h-3p | chr8 | 143304863 | 143304869 | 7mer-m8 | 143304862 | 143304882 | 154 | -16.46 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for TOP1MT |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for TOP1MT |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.73869907245987e-15 | 0.431451941667178 | 2.76209507935176e-25 | 0.544090947754135 | 7.7325957590702e-13 | 0.392156925352292 |
| AC | 4.09522022760964e-67 | 0.837758480664755 | 5.77857166485037e-49 | 0.76331801445454 | 1.68594957859259e-16 | 0.489938827484 |
| PCC | 1.78351416817617e-21 | 0.617645983491655 | 2.09765635333119e-19 | 0.591416359406618 | 4.24654896964253e-06 | 0.325782302069402 |
| CER | 8.51964784883268e-06 | 0.354565065774621 | 2.02951904089612e-11 | 0.512473295504261 | 2.7233056853412e-09 | 0.46174735343315 |
| TCX | 8.22828745708582e-11 | 0.498807938659832 | 0.00320954189819484 | 0.239114982220448 | 3.72387575975939e-07 | 0.400809218806419 |
| FP | 6.33452610147054e-11 | 0.464779439925883 | 0.000424297802062775 | 0.261404961721488 | 2.53036027124517e-13 | 0.51276035285956 |
| IFG | 0.000100675599186636 | 0.699211259032467 | 0.000328302298089412 | 0.660284895891636 | 0.000290877238238574 | 0.664541890972406 |
| PG | 0.016919121952146 | 0.174956908953482 | 0.0182334671196584 | 0.172964626901647 | 6.84103474624247e-06 | 0.323137322735612 |
| STG | 0.00900012262120903 | 0.283376541568725 | 0.114882833095335 | 0.173315737028527 | 4.68968813538244e-08 | 0.553666944976686 |
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Relation with AD stages for TOP1MT |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 1.01703753644965e-05 | 0.410585730954773 |
| TCX | 3.59141883666612e-08 | 0.504169475752347 |
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RelatedDrugs for TOP1MT |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| TOP1MT | Q969P6 | DB00762 | Irinotecan | DNA topoisomerase I, mitochondrial | small molecule | approved|investigational |
| TOP1MT | Q969P6 | DB01030 | Topotecan | DNA topoisomerase I, mitochondrial | small molecule | approved|investigational |
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RelatedDiseases for TOP1MT |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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