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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for OMA1 |
 Gene summary |
| Gene information | Gene symbol | OMA1 | Gene ID | 115209 |
| Gene name | OMA1 zinc metallopeptidase | |
| Synonyms | 2010001O09Rik|DAB1|MPRP-1|MPRP1|YKR087C|ZMPOMA1|peptidase | |
| Cytomap | 1p32.2-p32.1 | |
| Type of gene | protein-coding | |
| Description | metalloendopeptidase OMA1, mitochondrialOMA1 homolog, zinc metallopeptidaseOMA1 zinc metallopeptidase homologmetalloprotease-related protein 1overlapping activity with M-AAA proteaseoverlapping with the m-AAA protease 1 homologzinc metallopeptidase | |
| Modification date | 20200313 | |
| UniProtAcc | Q96E52, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for OMA1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_129663(58452043, -), ADediting_129664(58452048, -), ADediting_129665(58452049, -), ADediting_129666(58452061, -), ADediting_129667(58541516, -), ADediting_129668(58541533, -), ADediting_129669(58541534, -), ADediting_129670(58541540, -), ADediting_129671(58541573, -), ADediting_129672(58544655, -), ADediting_129673(58544667, -), ADediting_129674(58544685, -), ADediting_129675(58544686, -), ADediting_129676(58544690, -), ADediting_129677(58544691, -), ADediting_129678(58544718, -), ADediting_129679(58544722, -), ADediting_129680(58544758, -), ADediting_129681(58544767, -), ADediting_129682(58544771, -), ADediting_129683(58544772, -), ADediting_129684(58544773, -), ADediting_129685(58544787, -), ADediting_129686(58544821, -), ADediting_129687(58544826, -), ADediting_129688(58544836, -), ADediting_129689(58544869, -), ADediting_129690(58544875, -), ADediting_1520798(58541507, -), ADediting_1520799(58541555, -), ADediting_1520800(58541560, -), ADediting_1520801(58544764, -), |
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RNA editing positional annotations for OMA1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_129663 | chr1_58452043_- | intergenic |
| ADediting_129664 | chr1_58452048_- | intergenic |
| ADediting_129665 | chr1_58452049_- | intergenic |
| ADediting_129666 | chr1_58452061_- | intergenic |
| ADediting_129667 | chr1_58541516_- | UTR5 |
| ADediting_129668 | chr1_58541533_- | UTR5 |
| ADediting_129669 | chr1_58541534_- | UTR5 |
| ADediting_129670 | chr1_58541540_- | UTR5 |
| ADediting_129671 | chr1_58541573_- | UTR5 |
| ADediting_129672 | chr1_58544655_- | intronic |
| ADediting_129673 | chr1_58544667_- | intronic |
| ADediting_129674 | chr1_58544685_- | intronic |
| ADediting_129675 | chr1_58544686_- | intronic |
| ADediting_129676 | chr1_58544690_- | intronic |
| ADediting_129677 | chr1_58544691_- | intronic |
| ADediting_129678 | chr1_58544718_- | intronic |
| ADediting_129679 | chr1_58544722_- | intronic |
| ADediting_129680 | chr1_58544758_- | intronic |
| ADediting_129681 | chr1_58544767_- | intronic |
| ADediting_129682 | chr1_58544771_- | intronic |
| ADediting_129683 | chr1_58544772_- | intronic |
| ADediting_129684 | chr1_58544773_- | intronic |
| ADediting_129685 | chr1_58544787_- | intronic |
| ADediting_129686 | chr1_58544821_- | intronic |
| ADediting_129687 | chr1_58544826_- | intronic |
| ADediting_129688 | chr1_58544836_- | intronic |
| ADediting_129689 | chr1_58544869_- | intronic |
| ADediting_129690 | chr1_58544875_- | intronic |
| ADediting_1520798 | chr1_58541507_- | UTR5 |
| ADediting_1520799 | chr1_58541555_- | UTR5 |
| ADediting_1520800 | chr1_58541560_- | UTR5 |
| ADediting_1520801 | chr1_58544764_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_129663 | chr1_58452043_- | SINE | Alu | Name=AluSp |
| ADediting_129664 | chr1_58452048_- | SINE | Alu | Name=AluSp |
| ADediting_129665 | chr1_58452049_- | SINE | Alu | Name=AluSp |
| ADediting_129666 | chr1_58452061_- | SINE | Alu | Name=AluSp |
| ADediting_129667 | chr1_58541516_- | SINE | Alu | Name=AluSx |
| ADediting_129668 | chr1_58541533_- | SINE | Alu | Name=AluSx |
| ADediting_129669 | chr1_58541534_- | SINE | Alu | Name=AluSx |
| ADediting_129670 | chr1_58541540_- | SINE | Alu | Name=AluSx |
| ADediting_129671 | chr1_58541573_- | SINE | Alu | Name=AluSx |
| ADediting_129672 | chr1_58544655_- | SINE | Alu | Name=AluSz6 |
| ADediting_129673 | chr1_58544667_- | SINE | Alu | Name=AluSz6 |
| ADediting_129674 | chr1_58544685_- | SINE | Alu | Name=AluSz6 |
| ADediting_129675 | chr1_58544686_- | SINE | Alu | Name=AluSz6 |
| ADediting_129676 | chr1_58544690_- | SINE | Alu | Name=AluSz6 |
| ADediting_129677 | chr1_58544691_- | SINE | Alu | Name=AluSz6 |
| ADediting_129678 | chr1_58544718_- | SINE | Alu | Name=AluSz6 |
| ADediting_129679 | chr1_58544722_- | SINE | Alu | Name=AluSz6 |
| ADediting_129680 | chr1_58544758_- | SINE | Alu | Name=AluSz6 |
| ADediting_129681 | chr1_58544767_- | SINE | Alu | Name=AluSz6 |
| ADediting_129682 | chr1_58544771_- | SINE | Alu | Name=AluSz6 |
| ADediting_129683 | chr1_58544772_- | SINE | Alu | Name=AluSz6 |
| ADediting_129684 | chr1_58544773_- | SINE | Alu | Name=AluSz6 |
| ADediting_129685 | chr1_58544787_- | SINE | Alu | Name=AluSz6 |
| ADediting_129686 | chr1_58544821_- | SINE | Alu | Name=AluSz6 |
| ADediting_129687 | chr1_58544826_- | SINE | Alu | Name=AluSz6 |
| ADediting_129688 | chr1_58544836_- | SINE | Alu | Name=AluSz6 |
| ADediting_129689 | chr1_58544869_- | SINE | Alu | Name=AluSz6 |
| ADediting_129690 | chr1_58544875_- | SINE | Alu | Name=AluSz6 |
| ADediting_1520798 | chr1_58541507_- | SINE | Alu | Name=AluSx |
| ADediting_1520799 | chr1_58541555_- | SINE | Alu | Name=AluSx |
| ADediting_1520800 | chr1_58541560_- | SINE | Alu | Name=AluSx |
| ADediting_1520801 | chr1_58544764_- | SINE | Alu | Name=AluSz6 |
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RNA A-to-I editing events in the alternative splicing sites for OMA1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for OMA1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for OMA1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for OMA1 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1556067 | chr19_40282625_- | ENSG00000162600.12 | ENST00000421528.6 | OMA1-203 | hsa-miR-641 | chr1 | 58468478 | 58468484 | 7mer-m8 | 58468477 | 58468509 | 152 | -28.71 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000162600.12 | ENST00000421528.6 | OMA1-203 | hsa-miR-4775 | chr1 | 58468089 | 58468095 | 7mer-m8 | 58468088 | 58468110 | 157 | -9.14 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for OMA1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000453710.1 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1520798 | ENST00000453710.1 | chr1_58541507_- | 161 | -196.40 | -194.60 | -199.40 |
| ADediting_129667 | ENST00000453710.1 | chr1_58541516_- | 152 | -194.90 | -194.60 | -199.40 |
| ADediting_129668 | ENST00000453710.1 | chr1_58541533_- | 135 | -196.30 | -194.60 | -199.40 |
| ADediting_129669 | ENST00000453710.1 | chr1_58541534_- | 134 | -195.40 | -194.60 | -199.40 |
| ADediting_129670 | ENST00000453710.1 | chr1_58541540_- | 128 | -194.60 | -194.60 | -199.40 |
| ADediting_1520799 | ENST00000453710.1 | chr1_58541555_- | 113 | -193.90 | -194.60 | -199.40 |
| ADediting_1520800 | ENST00000453710.1 | chr1_58541560_- | 108 | -194.20 | -194.60 | -199.40 |
| ADediting_129671 | ENST00000453710.1 | chr1_58541573_- | 95 | -196.10 | -194.60 | -199.40 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for OMA1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.21082349542744e-10 | 0.355101301865674 | 2.0713186798825e-09 | 0.331970590492388 | 0.121015404255883 | 0.0882485479605654 |
| AC | 5.75407640207507e-38 | 0.69889342136645 | 6.84096680512903e-21 | 0.546766171877196 | 9.44837947796553e-26 | 0.599153450110488 |
| PCC | 2.87643375154289e-12 | 0.477450075506159 | 5.43662636225383e-09 | 0.406387489382001 | 1.67942553237657e-08 | 0.394187356196547 |
| CER | 0.000175469132906691 | -0.301698997678607 | 0.000942434749624904 | -0.267333776324878 | 0.615396948016769 | 0.0413478827678418 |
| TCX | 0.592979200987196 | 0.043990548510247 | 0.000887472880315733 | -0.268641246428708 | 4.37698273749678e-15 | 0.583962737992247 |
| FP | 4.4918300576662e-10 | 0.44579634879524 | 2.03455398869376e-14 | 0.532393037583709 | 0.0137797819024073 | 0.184320225488447 |
| IFG | 0.035803456646904 | 0.421615733421353 | 0.100326911272554 | 0.336218798382766 | 0.00848191218610439 | 0.514646256982484 |
| PG | 6.95732483657364e-33 | 0.735096754591834 | 6.27284470430587e-16 | 0.547353358330869 | 0.412465573103087 | 0.0604457464259171 |
| STG | 2.09565015883949e-06 | 0.491180976374467 | 0.00010148283568459 | 0.411337501702049 | 0.00149916506815071 | 0.341065166930368 |
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Relation with AD stages for OMA1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 0.00118381692429617 | 0.310810042189929 |
| IFG | 0.0498922693155063 | 0.396240626416652 |
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RelatedDrugs for OMA1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OMA1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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