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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for ELFN2 |
 Gene summary |
| Gene information | Gene symbol | ELFN2 | Gene ID | 114794 |
| Gene name | extracellular leucine rich repeat and fibronectin type III domain containing 2 | |
| Synonyms | LRRC62|PPP1R29 | |
| Cytomap | 22q13.1 | |
| Type of gene | protein-coding | |
| Description | protein phosphatase 1 regulatory subunit 29dJ63G5.3 (putative Leucine rich protein)leucine-rich repeat and fibronectin type-III domain-containing protein 6leucine-rich repeat-containing protein 62 | |
| Modification date | 20200313 | |
| UniProtAcc | Q5R3F8, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ELFN2 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
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RNA A-to-I events for ELFN2 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_988968(37369569, -), ADediting_988969(37374134, -), ADediting_988970(37382635, -), ADediting_988971(37384952, -), ADediting_988972(37384955, -), ADediting_988973(37388476, -), ADediting_988974(37389861, -), ADediting_988975(37390303, -), ADediting_988976(37392075, -), ADediting_988977(37397084, -), ADediting_988978(37405158, -), ADediting_988979(37405165, -), ADediting_988980(37405201, -), ADediting_988981(37405231, -), ADediting_988982(37405330, -), ADediting_988983(37405388, -), ADediting_988984(37405940, -), ADediting_988985(37406080, -), ADediting_988986(37407771, -), ADediting_988987(37407773, -), ADediting_988988(37407783, -), ADediting_988989(37407795, -), ADediting_988990(37408491, -), ADediting_988991(37413918, -), ADediting_988992(37414028, -), ADediting_988993(37422462, -), ADediting_988994(37422513, -), ADediting_988995(37422522, -), ADediting_988996(37422539, -), ADediting_988997(37422542, -), ADediting_988998(37422565, -), ADediting_988999(37422575, -), ADediting_989000(37422583, -), ADediting_989001(37422593, -), ADediting_989002(37422596, -), ADediting_989003(37422750, -), ADediting_989004(37422758, -), ADediting_989005(37422788, -), ADediting_989006(37422798, -), ADediting_989007(37422822, -), ADediting_989008(37422874, -), ADediting_989009(37422876, -), ADediting_989010(37423201, -), ADediting_1570493(37388714, -), ADediting_1570494(37422841, -), |
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RNA editing positional annotations for ELFN2 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_988969 | chr22_37374134_- | synonymous SNV | ENST00000613079.4 | c.A1401G | p.V467V | . | . | . |
| ADediting_988969 | chr22_37374134_- | synonymous SNV | ENST00000402918.7 | c.A1401G | p.V467V | . | . | . |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_988968 | chr22_37369569_- | ncRNA_intronic |
| ADediting_988969 | chr22_37374134_- | exonic |
| ADediting_988970 | chr22_37382635_- | ncRNA_intronic |
| ADediting_988971 | chr22_37384952_- | ncRNA_exonic |
| ADediting_988972 | chr22_37384955_- | ncRNA_exonic |
| ADediting_988973 | chr22_37388476_- | ncRNA_intronic |
| ADediting_988974 | chr22_37389861_- | ncRNA_intronic |
| ADediting_988975 | chr22_37390303_- | ncRNA_intronic |
| ADediting_988976 | chr22_37392075_- | ncRNA_intronic |
| ADediting_988977 | chr22_37397084_- | ncRNA_intronic |
| ADediting_988978 | chr22_37405158_- | ncRNA_intronic |
| ADediting_988979 | chr22_37405165_- | ncRNA_intronic |
| ADediting_988980 | chr22_37405201_- | ncRNA_intronic |
| ADediting_988981 | chr22_37405231_- | ncRNA_intronic |
| ADediting_988982 | chr22_37405330_- | ncRNA_intronic |
| ADediting_988983 | chr22_37405388_- | ncRNA_intronic |
| ADediting_988984 | chr22_37405940_- | ncRNA_intronic |
| ADediting_988985 | chr22_37406080_- | ncRNA_intronic |
| ADediting_988986 | chr22_37407771_- | ncRNA_intronic |
| ADediting_988987 | chr22_37407773_- | ncRNA_intronic |
| ADediting_988988 | chr22_37407783_- | ncRNA_intronic |
| ADediting_988989 | chr22_37407795_- | ncRNA_intronic |
| ADediting_988990 | chr22_37408491_- | ncRNA_intronic |
| ADediting_988991 | chr22_37413918_- | ncRNA_intronic |
| ADediting_988992 | chr22_37414028_- | ncRNA_intronic |
| ADediting_988993 | chr22_37422462_- | ncRNA_intronic |
| ADediting_988994 | chr22_37422513_- | ncRNA_intronic |
| ADediting_988995 | chr22_37422522_- | ncRNA_intronic |
| ADediting_988996 | chr22_37422539_- | ncRNA_intronic |
| ADediting_988997 | chr22_37422542_- | ncRNA_intronic |
| ADediting_988998 | chr22_37422565_- | ncRNA_intronic |
| ADediting_988999 | chr22_37422575_- | ncRNA_intronic |
| ADediting_989000 | chr22_37422583_- | ncRNA_intronic |
| ADediting_989001 | chr22_37422593_- | ncRNA_intronic |
| ADediting_989002 | chr22_37422596_- | ncRNA_intronic |
| ADediting_989003 | chr22_37422750_- | ncRNA_intronic |
| ADediting_989004 | chr22_37422758_- | ncRNA_intronic |
| ADediting_989005 | chr22_37422788_- | ncRNA_intronic |
| ADediting_989006 | chr22_37422798_- | ncRNA_intronic |
| ADediting_989007 | chr22_37422822_- | ncRNA_intronic |
| ADediting_989008 | chr22_37422874_- | ncRNA_intronic |
| ADediting_989009 | chr22_37422876_- | ncRNA_intronic |
| ADediting_989010 | chr22_37423201_- | ncRNA_intronic |
| ADediting_1570493 | chr22_37388714_- | ncRNA_intronic |
| ADediting_1570494 | chr22_37422841_- | ncRNA_intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_988970 | chr22_37382635_- | SINE | Alu | Name=AluSz |
| ADediting_988971 | chr22_37384952_- | LINE | L2 | Name=L2c |
| ADediting_988972 | chr22_37384955_- | LINE | L2 | Name=L2c |
| ADediting_988973 | chr22_37388476_- | SINE | MIR | Name=MIRb |
| ADediting_988974 | chr22_37389861_- | LINE | L2 | Name=L2b |
| ADediting_988975 | chr22_37390303_- | SINE | MIR | Name=MIRc |
| ADediting_988977 | chr22_37397084_- | LINE | L2 | Name=L2b |
| ADediting_988978 | chr22_37405158_- | SINE | Alu | Name=AluSx |
| ADediting_988979 | chr22_37405165_- | SINE | Alu | Name=AluSx |
| ADediting_988980 | chr22_37405201_- | SINE | Alu | Name=AluSx |
| ADediting_988981 | chr22_37405231_- | SINE | Alu | Name=AluSx |
| ADediting_988982 | chr22_37405330_- | SINE | Alu | Name=AluSx |
| ADediting_988983 | chr22_37405388_- | SINE | Alu | Name=AluSx |
| ADediting_988984 | chr22_37405940_- | SINE | Alu | Name=AluJb |
| ADediting_988985 | chr22_37406080_- | SINE | Alu | Name=AluJb |
| ADediting_988986 | chr22_37407771_- | SINE | Alu | Name=AluY |
| ADediting_988987 | chr22_37407773_- | SINE | Alu | Name=AluY |
| ADediting_988988 | chr22_37407783_- | SINE | Alu | Name=AluY |
| ADediting_988989 | chr22_37407795_- | SINE | Alu | Name=AluY |
| ADediting_988990 | chr22_37408491_- | SINE | MIR | Name=MIRb |
| ADediting_988991 | chr22_37413918_- | SINE | MIR | Name=MIRb |
| ADediting_988992 | chr22_37414028_- | SINE | MIR | Name=MIRb |
| ADediting_988993 | chr22_37422462_- | SINE | Alu | Name=AluSg |
| ADediting_988994 | chr22_37422513_- | SINE | Alu | Name=AluSg |
| ADediting_988995 | chr22_37422522_- | SINE | Alu | Name=AluSg |
| ADediting_988996 | chr22_37422539_- | SINE | Alu | Name=AluSg |
| ADediting_988997 | chr22_37422542_- | SINE | Alu | Name=AluSg |
| ADediting_988998 | chr22_37422565_- | SINE | Alu | Name=AluSg |
| ADediting_988999 | chr22_37422575_- | SINE | Alu | Name=AluSg |
| ADediting_989000 | chr22_37422583_- | SINE | Alu | Name=AluSg |
| ADediting_989001 | chr22_37422593_- | SINE | Alu | Name=AluSg |
| ADediting_989002 | chr22_37422596_- | SINE | Alu | Name=AluSg |
| ADediting_989003 | chr22_37422750_- | SINE | Alu | Name=AluSx |
| ADediting_989004 | chr22_37422758_- | SINE | Alu | Name=AluSx |
| ADediting_989005 | chr22_37422788_- | SINE | Alu | Name=AluSx |
| ADediting_989006 | chr22_37422798_- | SINE | Alu | Name=AluSx |
| ADediting_989007 | chr22_37422822_- | SINE | Alu | Name=AluSx |
| ADediting_989008 | chr22_37422874_- | SINE | Alu | Name=AluSx |
| ADediting_989009 | chr22_37422876_- | SINE | Alu | Name=AluSx |
| ADediting_1570493 | chr22_37388714_- | SINE | MIR | Name=MIRc |
| ADediting_1570494 | chr22_37422841_- | SINE | Alu | Name=AluSx |
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RNA A-to-I editing events in the alternative splicing sites for ELFN2 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ELFN2 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |