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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for SLC22A9 |
 Gene summary |
| Gene information | Gene symbol | SLC22A9 | Gene ID | 114571 |
| Gene name | solute carrier family 22 member 9 | |
| Synonyms | HOAT4|OAT4|OAT7|UST3H|ust3 | |
| Cytomap | 11q12.3 | |
| Type of gene | protein-coding | |
| Description | solute carrier family 22 member 9organic anion transporter 4organic anion transporter 7solute carrier family 22 (organic anion transporter), member 9solute carrier family 22 (organic anion/cation transporter), member 9 | |
| Modification date | 20200313 | |
| UniProtAcc | Q8IVM8, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| SLC22A9 | GO:0009914 | hormone transport | 17393504 |
| SLC22A9 | GO:0015913 | short-chain fatty acid import | 17393504 |
| SLC22A9 | GO:0043252 | sodium-independent organic anion transport | 17393504 |
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RNA A-to-I events for SLC22A9 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_263616(63370263, +), ADediting_263617(63370316, +), |
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RNA editing positional annotations for SLC22A9 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_263616 | chr11_63370263_+ | synonymous SNV | ENST00000536333.5 | c.A207G | p.Q69Q | . | . | . |
| ADediting_263616 | chr11_63370263_+ | synonymous SNV | ENST00000279178.4 | c.A207G | p.Q69Q | . | . | . |
| ADediting_263617 | chr11_63370316_+ | nonsynonymous SNV | ENST00000536333.5 | c.A260G | p.K87R | 0.034 | 0.968 | -2.63 |
| ADediting_263617 | chr11_63370316_+ | nonsynonymous SNV | ENST00000279178.4 | c.A260G | p.K87R | 0.034 | 0.968 | -2.63 |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_263616 | chr11_63370263_+ | exonic |
| ADediting_263617 | chr11_63370316_+ | exonic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
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RNA A-to-I editing events in the alternative splicing sites for SLC22A9 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SLC22A9 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for SLC22A9 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for SLC22A9 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for SLC22A9 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000279178.4 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_263616 | ENST00000279178.4 | chr11_63370263_+ | 479 | -753.10 | -751.70 | -753.20 |
| ADediting_263617 | ENST00000279178.4 | chr11_63370316_+ | 532 | -752.40 | -751.70 | -753.20 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for SLC22A9 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.10427580523896e-11 | 0.373248977119854 | 1.23075338585733e-10 | 0.354973566863074 | 2.31461952535644e-12 | 0.384507166751509 |
| PCC | 1.92521230081188e-10 | 0.439895435584696 | 1.19055783242464e-10 | 0.444428252828979 | 0.279891772458241 | 0.0785816187162927 |
| TCX | 3.35929117345936e-06 | 0.369072467830468 | 7.72253157761115e-13 | 0.542197568033148 | 1.15869144211494e-06 | -0.384846736857475 |
| FP | 1.21126656400093e-25 | 0.681439173165815 | 1.83998031473059e-30 | 0.726273683718047 | 0.163260295186388 | 0.104949528577322 |
| IFG | 0.00344995716758619 | 0.562118140156262 | 0.000156443392779647 | 0.685360515887033 | 0.466742532094016 | 0.152511026448419 |
| PG | 2.81756932850902e-20 | 0.609179213604948 | 7.51939452784991e-27 | 0.682541929511515 | 0.00543545837541714 | -0.203081880713196 |
| STG | 2.4503555832829e-13 | 0.694160441982662 | 5.62061548217415e-12 | 0.664293964401071 | 0.817419186834893 | -0.0255685049447283 |
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Relation with AD stages for SLC22A9 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| PG | 1.7616971872663e-06 | -0.342089102097445 |
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RelatedDrugs for SLC22A9 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC22A9 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| SLC22A9 | C1527249 | Colorectal Cancer | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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