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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for PADI2

check button Gene summary
Gene informationGene symbol

PADI2

Gene ID

11240

Gene namepeptidyl arginine deiminase 2
SynonymsPAD-H19|PAD2|PDI2
Cytomap

1p36.13

Type of geneprotein-coding
Descriptionprotein-arginine deiminase type-2peptidyl arginine deiminase, type IIprotein-arginine deiminase type II
Modification date20200313
UniProtAcc

Q9Y2J8,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
PADI2

GO:0010848

regulation of chromatin disassembly

22853951

PADI2

GO:0018101

protein citrullination

12392711|15629448|25621824

PADI2

GO:0036413

histone H3-R26 citrullination

22853951

PADI2

GO:0070100

negative regulation of chemokine-mediated signaling pathway

18645041

PADI2

GO:1901624

negative regulation of lymphocyte chemotaxis

18645041


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RNA A-to-I events for PADI2

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_43362(17079870, -), ADediting_43363(17082998, -), ADediting_43364(17083021, -), ADediting_43365(17083145, -), ADediting_43366(17083146, -), ADediting_43367(17083152, -), ADediting_43368(17083223, -), ADediting_43369(17083236, -), ADediting_43370(17083258, -), ADediting_43371(17083259, -), ADediting_43372(17083262, -), ADediting_43373(17083323, -), ADediting_43374(17083338, -), ADediting_43375(17087187, -), ADediting_43376(17087695, -), ADediting_43377(17088704, -), ADediting_43378(17088759, -), ADediting_43379(17088791, -), ADediting_43380(17092704, -), ADediting_43381(17092723, -), ADediting_43382(17092757, -), ADediting_43383(17092821, -), ADediting_43384(17092827, -), ADediting_43385(17092833, -), ADediting_43386(17092837, -), ADediting_43387(17092897, -), ADediting_43388(17092922, -), ADediting_43389(17093105, -), ADediting_43390(17093125, -), ADediting_43391(17093228, -), ADediting_43392(17093234, -), ADediting_43393(17093264, -), ADediting_43394(17093304, -), ADediting_43395(17093336, -), ADediting_43396(17093340, -), ADediting_43397(17104038, -), ADediting_43398(17104168, -), ADediting_43399(17104628, -), ADediting_43400(17104638, -), ADediting_43401(17104639, -), ADediting_43402(17104713, -), ADediting_43403(17104714, -), ADediting_43404(17104719, -), ADediting_43405(17104722, -), ADediting_43406(17105175, -), ADediting_43407(17105190, -), ADediting_43408(17105268, -), ADediting_43409(17105278, -), ADediting_43410(17105282, -), ADediting_43411(17105290, -), ADediting_43412(17105304, -), ADediting_43413(17105307, -), ADediting_43414(17105321, -), ADediting_43415(17105481, -), ADediting_43416(17105507, -), ADediting_43417(17105559, -), ADediting_43418(17105612, -), ADediting_43419(17105613, -), ADediting_43420(17105667, -), ADediting_43421(17107561, -), ADediting_43422(17108022, -), ADediting_43423(17108041, -), ADediting_43424(17109128, -), ADediting_43425(17109305, -), ADediting_43426(17109306, -), ADediting_43427(17109619, -), ADediting_43428(17109659, -), ADediting_43429(17109660, -), ADediting_43430(17109661, -), ADediting_43431(17109772, -), ADediting_1516353(17074510, -), ADediting_1516354(17092705, -), ADediting_1516355(17092713, -), ADediting_1516356(17093106, -), ADediting_1516357(17093265, -), ADediting_1597148(17092887, -),

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RNA editing positional annotations for PADI2 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_43362chr1_17079870_-intronic
ADediting_43363chr1_17082998_-intronic
ADediting_43364chr1_17083021_-intronic
ADediting_43365chr1_17083145_-intronic
ADediting_43366chr1_17083146_-intronic
ADediting_43367chr1_17083152_-intronic
ADediting_43368chr1_17083223_-intronic
ADediting_43369chr1_17083236_-intronic
ADediting_43370chr1_17083258_-intronic
ADediting_43371chr1_17083259_-intronic
ADediting_43372chr1_17083262_-intronic
ADediting_43373chr1_17083323_-intronic
ADediting_43374chr1_17083338_-intronic
ADediting_43375chr1_17087187_-intronic
ADediting_43376chr1_17087695_-intronic
ADediting_43377chr1_17088704_-intronic
ADediting_43378chr1_17088759_-intronic
ADediting_43379chr1_17088791_-intronic
ADediting_43380chr1_17092704_-intronic
ADediting_43381chr1_17092723_-intronic
ADediting_43382chr1_17092757_-intronic
ADediting_43383chr1_17092821_-intronic
ADediting_43384chr1_17092827_-intronic
ADediting_43385chr1_17092833_-intronic
ADediting_43386chr1_17092837_-intronic
ADediting_43387chr1_17092897_-intronic
ADediting_43388chr1_17092922_-intronic
ADediting_43389chr1_17093105_-intronic
ADediting_43390chr1_17093125_-intronic
ADediting_43391chr1_17093228_-intronic
ADediting_43392chr1_17093234_-intronic
ADediting_43393chr1_17093264_-intronic
ADediting_43394chr1_17093304_-intronic
ADediting_43395chr1_17093336_-intronic
ADediting_43396chr1_17093340_-intronic
ADediting_43397chr1_17104038_-intronic
ADediting_43398chr1_17104168_-intronic
ADediting_43399chr1_17104628_-intronic
ADediting_43400chr1_17104638_-intronic
ADediting_43401chr1_17104639_-intronic
ADediting_43402chr1_17104713_-intronic
ADediting_43403chr1_17104714_-intronic
ADediting_43404chr1_17104719_-intronic
ADediting_43405chr1_17104722_-intronic
ADediting_43406chr1_17105175_-intronic
ADediting_43407chr1_17105190_-intronic
ADediting_43408chr1_17105268_-intronic
ADediting_43409chr1_17105278_-intronic
ADediting_43410chr1_17105282_-intronic
ADediting_43411chr1_17105290_-intronic
ADediting_43412chr1_17105304_-intronic
ADediting_43413chr1_17105307_-intronic
ADediting_43414chr1_17105321_-intronic
ADediting_43415chr1_17105481_-intronic
ADediting_43416chr1_17105507_-intronic
ADediting_43417chr1_17105559_-intronic
ADediting_43418chr1_17105612_-intronic
ADediting_43419chr1_17105613_-intronic
ADediting_43420chr1_17105667_-intronic
ADediting_43421chr1_17107561_-intronic
ADediting_43422chr1_17108022_-intronic
ADediting_43423chr1_17108041_-intronic
ADediting_43424chr1_17109128_-intronic
ADediting_43425chr1_17109305_-intronic
ADediting_43426chr1_17109306_-intronic
ADediting_43427chr1_17109619_-intronic
ADediting_43428chr1_17109659_-intronic
ADediting_43429chr1_17109660_-intronic
ADediting_43430chr1_17109661_-intronic
ADediting_43431chr1_17109772_-intronic
ADediting_1516353chr1_17074510_-intronic
ADediting_1516354chr1_17092705_-intronic
ADediting_1516355chr1_17092713_-intronic
ADediting_1516356chr1_17093106_-intronic
ADediting_1516357chr1_17093265_-intronic
ADediting_1597148chr1_17092887_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_43362chr1_17079870_-SINEAluName=AluSz
ADediting_43363chr1_17082998_-SINEAluName=AluJr4
ADediting_43364chr1_17083021_-SINEAluName=AluJr4
ADediting_43365chr1_17083145_-SINEAluName=AluJr4
ADediting_43366chr1_17083146_-SINEAluName=AluJr4
ADediting_43367chr1_17083152_-SINEAluName=AluJr4
ADediting_43368chr1_17083223_-SINEAluName=AluSx3
ADediting_43369chr1_17083236_-SINEAluName=AluSx3
ADediting_43370chr1_17083258_-SINEAluName=AluSx3
ADediting_43371chr1_17083259_-SINEAluName=AluSx3
ADediting_43372chr1_17083262_-SINEAluName=AluSx3
ADediting_43373chr1_17083323_-SINEAluName=AluSx3
ADediting_43374chr1_17083338_-SINEAluName=AluSx3
ADediting_43376chr1_17087695_-SINEAluName=AluSx1
ADediting_43377chr1_17088704_-SINEAluName=AluSg
ADediting_43378chr1_17088759_-SINEAluName=AluSg
ADediting_43379chr1_17088791_-SINEAluName=AluSg
ADediting_43380chr1_17092704_-SINEAluName=AluJr
ADediting_43381chr1_17092723_-SINEAluName=AluJr
ADediting_43382chr1_17092757_-SINEAluName=AluJr
ADediting_43383chr1_17092821_-SINEAluName=AluJr
ADediting_43384chr1_17092827_-SINEAluName=AluJr
ADediting_43385chr1_17092833_-SINEAluName=AluJr
ADediting_43386chr1_17092837_-SINEAluName=AluJr
ADediting_43387chr1_17092897_-SINEAluName=AluJr
ADediting_43388chr1_17092922_-SINEAluName=AluJr
ADediting_43389chr1_17093105_-SINEAluName=AluSg
ADediting_43390chr1_17093125_-SINEAluName=AluSg
ADediting_43391chr1_17093228_-SINEAluName=AluSg
ADediting_43392chr1_17093234_-SINEAluName=AluSg
ADediting_43393chr1_17093264_-SINEAluName=AluSg
ADediting_43394chr1_17093304_-SINEAluName=AluSg
ADediting_43395chr1_17093336_-SINEAluName=AluSg
ADediting_43396chr1_17093340_-SINEAluName=AluSg
ADediting_43397chr1_17104038_-SINEAluName=AluY
ADediting_43398chr1_17104168_-SINEAluName=AluY
ADediting_43399chr1_17104628_-SINEAluName=AluYm1
ADediting_43400chr1_17104638_-SINEAluName=AluYm1
ADediting_43401chr1_17104639_-SINEAluName=AluYm1
ADediting_43402chr1_17104713_-SINEAluName=AluYm1
ADediting_43403chr1_17104714_-SINEAluName=AluYm1
ADediting_43404chr1_17104719_-SINEAluName=AluYm1
ADediting_43405chr1_17104722_-SINEAluName=AluYm1
ADediting_43406chr1_17105175_-SINEAluName=AluJb
ADediting_43407chr1_17105190_-SINEAluName=AluJb
ADediting_43408chr1_17105268_-SINEAluName=AluJb
ADediting_43409chr1_17105278_-SINEAluName=AluJb
ADediting_43410chr1_17105282_-SINEAluName=AluJb
ADediting_43411chr1_17105290_-SINEAluName=AluJb
ADediting_43412chr1_17105304_-SINEAluName=AluJb
ADediting_43413chr1_17105307_-SINEAluName=AluJb
ADediting_43414chr1_17105321_-SINEAluName=AluJb
ADediting_43415chr1_17105481_-SINEAluName=AluSp
ADediting_43416chr1_17105507_-SINEAluName=AluSp
ADediting_43417chr1_17105559_-SINEAluName=AluSp
ADediting_43418chr1_17105612_-SINEAluName=AluSp
ADediting_43419chr1_17105613_-SINEAluName=AluSp
ADediting_43420chr1_17105667_-SINEAluName=AluSp
ADediting_43421chr1_17107561_-DNAhAT-CharlieName=MER5A
ADediting_43422chr1_17108022_-SINEAluName=AluSx1
ADediting_43423chr1_17108041_-SINEAluName=AluSx1
ADediting_43424chr1_17109128_-SINEAluName=AluSz6
ADediting_43425chr1_17109305_-SINEAluName=AluSz6
ADediting_43426chr1_17109306_-SINEAluName=AluSz6
ADediting_43427chr1_17109619_-SINEAluName=AluSz
ADediting_43428chr1_17109659_-SINEAluName=AluSz
ADediting_43429chr1_17109660_-SINEAluName=AluSz
ADediting_43430chr1_17109661_-SINEAluName=AluSz
ADediting_43431chr1_17109772_-SINEAluName=AluSz
ADediting_1516353chr1_17074510_-SINEAluName=AluJo
ADediting_1516354chr1_17092705_-SINEAluName=AluJr
ADediting_1516355chr1_17092713_-SINEAluName=AluJr
ADediting_1516356chr1_17093106_-SINEAluName=AluSg
ADediting_1516357chr1_17093265_-SINEAluName=AluSg
ADediting_1597148chr1_17092887_-SINEAluName=AluJr

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RNA A-to-I editing events in the alternative splicing sites for PADI2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PADI2

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for PADI2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for PADI2

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_43363chr1_17082998_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-5690chr117082998170830047mer-m81708299717083017147-17.3
ADediting_43363chr1_17082998_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-646chr117082996170830027mer-m81708299517083014152-22.21
ADediting_43369chr1_17083236_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-302a-3pchr117083134170832377mer-m81708313317083252153-17.21
ADediting_43369chr1_17083236_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-302b-3pchr117083134170832377mer-m81708313317083252145-8.7
ADediting_43369chr1_17083236_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-302c-3pchr117083134170832377mer-m81708313317083252145-14.31
ADediting_43369chr1_17083236_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-302d-3pchr117083134170832377mer-m81708313317083251150-15.65
ADediting_43369chr1_17083236_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-302echr117083134170832377mer-m81708313317083246143-10.86
ADediting_43369chr1_17083236_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-372-3pchr117083134170832377mer-m81708313317083251158-20.92
ADediting_43369chr1_17083236_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-373-3pchr117083134170832377mer-m81708313317083252165-24.39
ADediting_43369chr1_17083236_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-512-3pchr117083135170832387mer-m81708313417083251162-26.34
ADediting_43369chr1_17083236_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-520a-3pchr117083134170832377mer-m81708313317083251140-14.1
ADediting_43369chr1_17083236_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-520b-3pchr117083134170832377mer-m81708313317083250140-16.07
ADediting_43369chr1_17083236_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-520c-3pchr117083134170832377mer-m81708313317083251140-16.07
ADediting_43369chr1_17083236_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-520d-3pchr117083134170832377mer-m81708313317083254143-23.51
ADediting_43369chr1_17083236_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-520e-3pchr117083134170832377mer-m81708313317083250143-19.64
ADediting_43370chr1_17083258_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-1288-3pchr117083255170832617mer-m81708325417083273144-17.47
ADediting_43370chr1_17083258_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-3169chr117083254170832607mer-m81708325317083273146-17
ADediting_43372chr1_17083262_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-4774-3pchr117083258170832647mer-m81708325717083276149-15.51
ADediting_43373chr1_17083323_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-4486chr117083318170833247mer-m81708331717083333145-18.64
ADediting_43374chr1_17083338_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-340-3pchr117083338170833447mer-m81708333717083358149-19.3
ADediting_43374chr1_17083338_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-6827-3pchr117083338170833447mer-m81708333717083357140-14.58

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_43363chr1_17082998_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-6869-5pchr117082994170830007mer-m81708299317083013150-19.11
ADediting_43364chr1_17083021_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-4999-3pchr117083018170830247mer-m81708301717083037148-14.89
ADediting_43369chr1_17083236_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-3147chr117083137170832407mer-1a1708313717083258140-27.12
ADediting_43369chr1_17083236_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-4425chr117083137170832418mer-1a1708313717083254147-17.02
ADediting_43369chr1_17083236_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-887-5pchr117083236170832427mer-m81708313817083254143-13.45
ADediting_43372chr1_17083262_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-4720-3pchr117083259170832668mer-1a1708325917083280144-16.05
ADediting_43373chr1_17083323_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-1262chr117083319170833257mer-m81708331817083339140-15.42
ADediting_43373chr1_17083323_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-4701-3pchr117083319170833257mer-m81708331817083338153-22.37
ADediting_43373chr1_17083323_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-6736-5pchr117083319170833257mer-m81708331817083338143-20.84
ADediting_43374chr1_17083338_-ENSG00000117115.13ENST00000466151.1PADI2-203hsa-miR-6790-3pchr117083334170833407mer-m81708333317083353142-14.42

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000117115.13ENST00000375486.9PADI2-202hsa-miR-5688chr117067269170672768mer-1a1706726917067290142-16.18
ADediting_1337757chr7_5495852_-ENSG00000117115.13ENST00000375486.9PADI2-202hsa-miR-589-3pchr117068651170686588mer-1a1706865117068672147-18.84
ADediting_1391023chr8_140732605_-ENSG00000117115.13ENST00000375486.9PADI2-202hsa-miR-151a-3pchr117067548170675547mer-m81706754717067567147-15.22
ADediting_496066chr15_66496985_-ENSG00000117115.13ENST00000375486.9PADI2-202hsa-miR-4512chr117067452170674587mer-m81706745117067472140-13.78
ADediting_843620chr2_207754818_+ENSG00000117115.13ENST00000375481.1PADI2-201hsa-miR-4775chr117079102170791098mer-1a1707910217079122155-12.16
ADediting_843620chr2_207754818_+ENSG00000117115.13ENST00000375486.9PADI2-202hsa-miR-4775chr117068644170686518mer-1a1706864417068665143-9.16
ADediting_98289chr1_32086992_+ENSG00000117115.13ENST00000375486.9PADI2-202hsa-miR-5585-3pchr117067732170677398mer-1a1706773217067753149-12.94

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_107020chr1_37500952_-ENSG00000117115.13ENST00000375486.9PADI2-202hsa-miR-5581-3pchr117067633170676408mer-1a1706763317067654145-18.17
ADediting_291761chr11_93733708_-ENSG00000117115.13ENST00000375486.9PADI2-202hsa-miR-1304-3pchr117068850170688567mer-m81706884917068874141-12.47

check button Differentially expressed gene-miRNA network
Differentially expressed lncRNA-miRNA network
boxplot

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The effects of the RNA editing to the stability of the RNA structures for PADI2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000466151.1lncRNASoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_43363ENST00000466151.1chr1_17082998_-332-1326.20-1325.60-1344.20
ADediting_43364ENST00000466151.1chr1_17083021_-309-1327.89-1325.60-1344.20
ADediting_43369ENST00000466151.1chr1_17083236_-191-1325.30-1325.60-1344.20
ADediting_43370ENST00000466151.1chr1_17083258_-169-1326.50-1325.60-1344.20
ADediting_43371ENST00000466151.1chr1_17083259_-168-1327.00-1325.60-1344.20
ADediting_43372ENST00000466151.1chr1_17083262_-165-1330.29-1325.60-1344.20
ADediting_43373ENST00000466151.1chr1_17083323_-104-1329.20-1325.60-1344.20
ADediting_43374ENST00000466151.1chr1_17083338_-89-1332.20-1325.60-1344.20

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Relation with ADAR for PADI2

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
TCXADediting_43365chr1_17083145_-0.001058845884013060.264780840483350.470151424818758-0.05941496225718780.0001787987898399670.301337695685992
DLPFCADediting_43367chr1_17083152_-1.74592190804912e-060.267643176791250.01281503858896440.1412196088792322.14113842810316e-120.385057346846686
DLPFCADediting_43410chr1_17105282_-0.0929366879851940.09559114538908660.433520695896025-0.04463986042315122.7651288174944e-110.366426964534747
DLPFCADediting_43412chr1_17105304_-0.1333395982964860.08544377129196620.918075280560901-0.00586561527317126.33207144643624e-100.341856841998233
DLPFCADediting_43413chr1_17105307_-0.05449833321522070.1093248863231390.7790917223951510.01599508958226316.48039867504768e-090.322111532166318
DLPFCADediting_43416chr1_17105507_-0.05079127231237280.1110418069022340.7791926977973820.01598758464808133.42814780551341e-110.364806064468278
DLPFCADediting_43419chr1_17105613_-0.1292541880185250.08635044663993170.559176638160213-0.03329797342069249.23953926106393e-150.421188428720595

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC4.81500967115406e-090.3247132912821621.67011378137933e-050.2418434907360566.18702921974429e-100.34204670663427
AC4.15361413874218e-390.7064973601072925.28668827713991e-210.5480836114719542.57350270708085e-240.584636213066785
PCC0.000406752774843650.2533091204314180.01803555912242840.1709776162144554.22912333829213e-070.356266424837348
TCX0.0002202857925203610.2972951140997340.00322078018996088-0.2390298210976636.39948727838254e-200.657403499818815
FP0.01508997244625070.1819112846562710.25914795346698-0.08502346749832893.01492532442505e-120.492151664297668
IFG0.1028185796401340.333920211835240.8916155017194210.02871670821911170.0003343734237335880.659634634696513
PG5.10583125077812e-070.3583633531623290.912972183054464-0.008067816142981283.24771181611563e-100.440164308811095
STG0.01245633194601110.2715813092306420.377187581287594-0.09758498947253252.73153531317211e-070.526237929054722

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Relation with AD stages for PADI2

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
TCXADediting_43364chr1_17083021_-0.0008745967407982770.318560384502511
TCXADediting_43367chr1_17083152_-0.0007734427380414630.321649231767413

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
PCC2.41496939884536e-060.333546611362856
TCX4.80424626543652e-080.500110987555266
PG2.13215497747903e-090.421255076620316

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RelatedDrugs for PADI2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PADI2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
PADI2C0036341Schizophrenia1PSYGENET