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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for CPSF6 |
 Gene summary |
| Gene information | Gene symbol | CPSF6 | Gene ID | 11052 |
| Gene name | cleavage and polyadenylation specific factor 6 | |
| Synonyms | CFIM|CFIM68|CFIM72|HPBRII-4|HPBRII-7 | |
| Cytomap | 12q15 | |
| Type of gene | protein-coding | |
| Description | cleavage and polyadenylation specificity factor subunit 6CPSF 68 kDa subunitcleavage and polyadenylation specific factor 6, 68kDacleavage and polyadenylation specificity factor 68 kDa subunitcleavage factor Im complex 68 kDa subunitpre-mRNA cleavage | |
| Modification date | 20200313 | |
| UniProtAcc | Q16630, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CPSF6 | GO:0006397 | mRNA processing | 14690600 |
| CPSF6 | GO:0051262 | protein tetramerization | 20695905 |
| CPSF6 | GO:0051290 | protein heterotetramerization | 23187700 |
| CPSF6 | GO:1990120 | messenger ribonucleoprotein complex assembly | 29276085 |
Top |
RNA A-to-I events for CPSF6 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_369525(69242876, +), ADediting_369526(69242966, +), ADediting_369527(69242987, +), ADediting_369528(69242988, +), ADediting_369529(69243027, +), ADediting_369530(69243028, +), ADediting_369531(69243908, +), ADediting_369532(69243913, +), ADediting_369533(69243920, +), ADediting_369534(69243927, +), ADediting_369535(69243933, +), ADediting_369536(69243934, +), ADediting_369537(69243937, +), ADediting_369538(69243951, +), ADediting_369539(69243958, +), ADediting_369540(69243963, +), ADediting_369541(69243973, +), ADediting_369542(69243979, +), ADediting_369543(69244036, +), ADediting_369544(69244056, +), ADediting_369545(69244057, +), ADediting_369546(69244094, +), ADediting_369547(69244404, +), ADediting_369548(69244633, +), ADediting_369549(69244997, +), ADediting_369550(69245048, +), ADediting_369551(69245808, +), ADediting_369552(69245828, +), ADediting_369553(69245854, +), ADediting_369554(69245866, +), ADediting_369555(69245876, +), ADediting_369556(69245922, +), ADediting_369557(69245926, +), ADediting_369558(69245928, +), ADediting_369559(69245929, +), ADediting_369560(69245940, +), ADediting_369561(69245944, +), ADediting_369562(69245948, +), ADediting_369563(69245951, +), ADediting_369564(69245953, +), ADediting_369565(69245960, +), ADediting_369566(69245966, +), ADediting_369567(69245967, +), ADediting_369568(69245976, +), ADediting_369569(69245981, +), ADediting_369570(69245996, +), ADediting_369571(69245998, +), ADediting_369572(69246007, +), ADediting_369573(69246008, +), ADediting_369574(69246019, +), ADediting_369575(69246028, +), ADediting_369576(69246042, +), ADediting_369577(69246873, +), ADediting_369578(69248992, +), ADediting_369579(69250666, +), ADediting_369580(69250672, +), ADediting_369581(69250703, +), ADediting_369582(69250708, +), ADediting_369583(69250740, +), ADediting_369584(69250746, +), ADediting_369585(69250747, +), ADediting_369586(69250764, +), ADediting_369587(69250776, +), ADediting_369588(69250827, +), ADediting_369589(69250836, +), ADediting_369590(69250881, +), ADediting_369591(69250882, +), ADediting_369592(69250920, +), ADediting_369593(69250936, +), ADediting_369594(69255041, +), ADediting_369595(69255048, +), ADediting_369596(69255297, +), ADediting_369597(69255971, +), ADediting_369598(69255980, +), ADediting_369599(69256050, +), ADediting_369600(69256051, +), ADediting_369601(69256052, +), ADediting_369602(69257815, +), ADediting_369603(69260851, +), ADediting_369604(69260852, +), ADediting_369605(69260909, +), ADediting_369606(69261347, +), ADediting_1533920(69242854, +), ADediting_1533921(69242862, +), ADediting_1533922(69242870, +), ADediting_1533923(69243013, +), ADediting_1533924(69244588, +), ADediting_1533925(69245931, +), ADediting_1533926(69255069, +), ADediting_1533927(69255124, +), ADediting_1533928(69255126, +), ADediting_1533929(69255131, +), ADediting_1533930(69255136, +), ADediting_1533931(69255137, +), ADediting_1533932(69255145, +), ADediting_1533933(69255172, +), ADediting_1533934(69255187, +), ADediting_1533935(69255214, +), ADediting_1533936(69255227, +), ADediting_1533937(69256102, +), ADediting_1533938(69256107, +), ADediting_1533939(69256108, +), ADediting_1533940(69256123, +), ADediting_1533941(69256139, +), ADediting_1533942(69256151, +), ADediting_1533943(69256157, +), ADediting_1533944(69256158, +), ADediting_1533945(69256226, +), ADediting_1533946(69261338, +), ADediting_1614702(69242853, +), ADediting_1614703(69243010, +), ADediting_1614704(69243035, +), ADediting_1614705(69245935, +), ADediting_1614706(69250844, +), ADediting_1614707(69255000, +), ADediting_1614708(69255186, +), |
Top |
RNA editing positional annotations for CPSF6 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_1533926 | chr12_69255069_+ | nonsynonymous SNV | ENST00000650046.1 | c.A442G | p.I148V | . | . | . |
| ADediting_1533927 | chr12_69255124_+ | synonymous SNV | ENST00000650046.1 | c.A497G | p.X166X | . | . | . |
| ADediting_369594 | chr12_69255041_+ | synonymous SNV | ENST00000650046.1 | c.A414G | p.L138L | . | . | . |
| ADediting_369595 | chr12_69255048_+ | nonsynonymous SNV | ENST00000650046.1 | c.A421G | p.T141A | . | . | . |
| ADediting_369602 | chr12_69257815_+ | nonsynonymous SNV | ENST00000435070.7 | c.A604G | p.R202G | 0.057 | 0.001 | -0.32 |
| ADediting_369602 | chr12_69257815_+ | nonsynonymous SNV | ENST00000266679.8 | c.A604G | p.R202G | 0.057 | 0.001 | -0.32 |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_369525 | chr12_69242876_+ | intronic |
| ADediting_369526 | chr12_69242966_+ | intronic |
| ADediting_369527 | chr12_69242987_+ | intronic |
| ADediting_369528 | chr12_69242988_+ | intronic |
| ADediting_369529 | chr12_69243027_+ | intronic |
| ADediting_369530 | chr12_69243028_+ | intronic |
| ADediting_369531 | chr12_69243908_+ | intronic |
| ADediting_369532 | chr12_69243913_+ | intronic |
| ADediting_369533 | chr12_69243920_+ | intronic |
| ADediting_369534 | chr12_69243927_+ | intronic |
| ADediting_369535 | chr12_69243933_+ | intronic |
| ADediting_369536 | chr12_69243934_+ | intronic |
| ADediting_369537 | chr12_69243937_+ | intronic |
| ADediting_369538 | chr12_69243951_+ | intronic |
| ADediting_369539 | chr12_69243958_+ | intronic |
| ADediting_369540 | chr12_69243963_+ | intronic |
| ADediting_369541 | chr12_69243973_+ | intronic |
| ADediting_369542 | chr12_69243979_+ | intronic |
| ADediting_369543 | chr12_69244036_+ | intronic |
| ADediting_369544 | chr12_69244056_+ | intronic |
| ADediting_369545 | chr12_69244057_+ | intronic |
| ADediting_369546 | chr12_69244094_+ | intronic |
| ADediting_369547 | chr12_69244404_+ | intronic |
| ADediting_369548 | chr12_69244633_+ | intronic |
| ADediting_369549 | chr12_69244997_+ | intronic |
| ADediting_369550 | chr12_69245048_+ | intronic |
| ADediting_369551 | chr12_69245808_+ | intronic |
| ADediting_369552 | chr12_69245828_+ | intronic |
| ADediting_369553 | chr12_69245854_+ | intronic |
| ADediting_369554 | chr12_69245866_+ | intronic |
| ADediting_369555 | chr12_69245876_+ | intronic |
| ADediting_369556 | chr12_69245922_+ | intronic |
| ADediting_369557 | chr12_69245926_+ | intronic |
| ADediting_369558 | chr12_69245928_+ | intronic |
| ADediting_369559 | chr12_69245929_+ | intronic |
| ADediting_369560 | chr12_69245940_+ | intronic |
| ADediting_369561 | chr12_69245944_+ | intronic |
| ADediting_369562 | chr12_69245948_+ | intronic |
| ADediting_369563 | chr12_69245951_+ | intronic |
| ADediting_369564 | chr12_69245953_+ | intronic |
| ADediting_369565 | chr12_69245960_+ | intronic |
| ADediting_369566 | chr12_69245966_+ | intronic |
| ADediting_369567 | chr12_69245967_+ | intronic |
| ADediting_369568 | chr12_69245976_+ | intronic |
| ADediting_369569 | chr12_69245981_+ | intronic |
| ADediting_369570 | chr12_69245996_+ | intronic |
| ADediting_369571 | chr12_69245998_+ | intronic |
| ADediting_369572 | chr12_69246007_+ | intronic |
| ADediting_369573 | chr12_69246008_+ | intronic |
| ADediting_369574 | chr12_69246019_+ | intronic |
| ADediting_369575 | chr12_69246028_+ | intronic |
| ADediting_369576 | chr12_69246042_+ | intronic |
| ADediting_369577 | chr12_69246873_+ | intronic |
| ADediting_369578 | chr12_69248992_+ | intronic |
| ADediting_369579 | chr12_69250666_+ | intronic |
| ADediting_369580 | chr12_69250672_+ | intronic |
| ADediting_369581 | chr12_69250703_+ | intronic |
| ADediting_369582 | chr12_69250708_+ | intronic |
| ADediting_369583 | chr12_69250740_+ | intronic |
| ADediting_369584 | chr12_69250746_+ | intronic |
| ADediting_369585 | chr12_69250747_+ | intronic |
| ADediting_369586 | chr12_69250764_+ | intronic |
| ADediting_369587 | chr12_69250776_+ | intronic |
| ADediting_369588 | chr12_69250827_+ | intronic |
| ADediting_369589 | chr12_69250836_+ | intronic |
| ADediting_369590 | chr12_69250881_+ | intronic |
| ADediting_369591 | chr12_69250882_+ | intronic |
| ADediting_369592 | chr12_69250920_+ | intronic |
| ADediting_369593 | chr12_69250936_+ | intronic |
| ADediting_369594 | chr12_69255041_+ | exonic |
| ADediting_369595 | chr12_69255048_+ | exonic |
| ADediting_369596 | chr12_69255297_+ | UTR3 |
| ADediting_369597 | chr12_69255971_+ | UTR3 |
| ADediting_369598 | chr12_69255980_+ | UTR3 |
| ADediting_369599 | chr12_69256050_+ | UTR3 |
| ADediting_369600 | chr12_69256051_+ | UTR3 |
| ADediting_369601 | chr12_69256052_+ | UTR3 |
| ADediting_369602 | chr12_69257815_+ | exonic |
| ADediting_369603 | chr12_69260851_+ | intronic |
| ADediting_369604 | chr12_69260852_+ | intronic |
| ADediting_369605 | chr12_69260909_+ | intronic |
| ADediting_369606 | chr12_69261347_+ | intronic |
| ADediting_1533920 | chr12_69242854_+ | intronic |
| ADediting_1533921 | chr12_69242862_+ | intronic |
| ADediting_1533922 | chr12_69242870_+ | intronic |
| ADediting_1533923 | chr12_69243013_+ | intronic |
| ADediting_1533924 | chr12_69244588_+ | intronic |
| ADediting_1533925 | chr12_69245931_+ | intronic |
| ADediting_1533926 | chr12_69255069_+ | exonic |
| ADediting_1533927 | chr12_69255124_+ | exonic |
| ADediting_1533928 | chr12_69255126_+ | UTR3 |
| ADediting_1533929 | chr12_69255131_+ | UTR3 |
| ADediting_1533930 | chr12_69255136_+ | UTR3 |
| ADediting_1533931 | chr12_69255137_+ | UTR3 |
| ADediting_1533932 | chr12_69255145_+ | UTR3 |
| ADediting_1533933 | chr12_69255172_+ | UTR3 |
| ADediting_1533934 | chr12_69255187_+ | UTR3 |
| ADediting_1533935 | chr12_69255214_+ | UTR3 |
| ADediting_1533936 | chr12_69255227_+ | UTR3 |
| ADediting_1533937 | chr12_69256102_+ | intronic |
| ADediting_1533938 | chr12_69256107_+ | intronic |
| ADediting_1533939 | chr12_69256108_+ | intronic |
| ADediting_1533940 | chr12_69256123_+ | intronic |
| ADediting_1533941 | chr12_69256139_+ | intronic |
| ADediting_1533942 | chr12_69256151_+ | intronic |
| ADediting_1533943 | chr12_69256157_+ | intronic |
| ADediting_1533944 | chr12_69256158_+ | intronic |
| ADediting_1533945 | chr12_69256226_+ | intronic |
| ADediting_1533946 | chr12_69261338_+ | intronic |
| ADediting_1614702 | chr12_69242853_+ | intronic |
| ADediting_1614703 | chr12_69243010_+ | intronic |
| ADediting_1614704 | chr12_69243035_+ | intronic |
| ADediting_1614705 | chr12_69245935_+ | intronic |
| ADediting_1614706 | chr12_69250844_+ | intronic |
| ADediting_1614707 | chr12_69255000_+ | splicing |
| ADediting_1614708 | chr12_69255186_+ | UTR3 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_369525 | chr12_69242876_+ | SINE | Alu | Name=AluSz |
| ADediting_369526 | chr12_69242966_+ | SINE | Alu | Name=AluSz |
| ADediting_369527 | chr12_69242987_+ | SINE | Alu | Name=AluSz |
| ADediting_369528 | chr12_69242988_+ | SINE | Alu | Name=AluSz |
| ADediting_369529 | chr12_69243027_+ | SINE | Alu | Name=AluSz |
| ADediting_369530 | chr12_69243028_+ | SINE | Alu | Name=AluSz |
| ADediting_369531 | chr12_69243908_+ | SINE | Alu | Name=AluJb |
| ADediting_369532 | chr12_69243913_+ | SINE | Alu | Name=AluJb |
| ADediting_369533 | chr12_69243920_+ | SINE | Alu | Name=AluJb |
| ADediting_369534 | chr12_69243927_+ | SINE | Alu | Name=AluJb |
| ADediting_369535 | chr12_69243933_+ | SINE | Alu | Name=AluJb |
| ADediting_369536 | chr12_69243934_+ | SINE | Alu | Name=AluJb |
| ADediting_369537 | chr12_69243937_+ | SINE | Alu | Name=AluJb |
| ADediting_369538 | chr12_69243951_+ | SINE | Alu | Name=AluJb |
| ADediting_369539 | chr12_69243958_+ | SINE | Alu | Name=AluJb |
| ADediting_369540 | chr12_69243963_+ | SINE | Alu | Name=AluJb |
| ADediting_369541 | chr12_69243973_+ | SINE | Alu | Name=AluJb |
| ADediting_369542 | chr12_69243979_+ | SINE | Alu | Name=AluJb |
| ADediting_369543 | chr12_69244036_+ | SINE | Alu | Name=AluJb |
| ADediting_369544 | chr12_69244056_+ | SINE | Alu | Name=AluJb |
| ADediting_369545 | chr12_69244057_+ | SINE | Alu | Name=AluJb |
| ADediting_369546 | chr12_69244094_+ | SINE | Alu | Name=AluJb |
| ADediting_369547 | chr12_69244404_+ | SINE | Alu | Name=AluSz |
| ADediting_369548 | chr12_69244633_+ | SINE | Alu | Name=FLAM_C |
| ADediting_369549 | chr12_69244997_+ | SINE | Alu | Name=AluSz6 |
| ADediting_369550 | chr12_69245048_+ | SINE | Alu | Name=AluSz6 |
| ADediting_369551 | chr12_69245808_+ | SINE | Alu | Name=AluSz |
| ADediting_369552 | chr12_69245828_+ | SINE | Alu | Name=AluSz |
| ADediting_369553 | chr12_69245854_+ | SINE | Alu | Name=AluSz |
| ADediting_369554 | chr12_69245866_+ | SINE | Alu | Name=AluSz |
| ADediting_369555 | chr12_69245876_+ | SINE | Alu | Name=AluSz |
| ADediting_369556 | chr12_69245922_+ | SINE | Alu | Name=AluSz |
| ADediting_369557 | chr12_69245926_+ | SINE | Alu | Name=AluSz |
| ADediting_369558 | chr12_69245928_+ | SINE | Alu | Name=AluSz |
| ADediting_369559 | chr12_69245929_+ | SINE | Alu | Name=AluSz |
| ADediting_369560 | chr12_69245940_+ | SINE | Alu | Name=AluSz |
| ADediting_369561 | chr12_69245944_+ | SINE | Alu | Name=AluSz |
| ADediting_369562 | chr12_69245948_+ | SINE | Alu | Name=AluSz |
| ADediting_369563 | chr12_69245951_+ | SINE | Alu | Name=AluSz |
| ADediting_369564 | chr12_69245953_+ | SINE | Alu | Name=AluSz |
| ADediting_369565 | chr12_69245960_+ | SINE | Alu | Name=AluSz |
| ADediting_369566 | chr12_69245966_+ | SINE | Alu | Name=AluSz |
| ADediting_369567 | chr12_69245967_+ | SINE | Alu | Name=AluSz |
| ADediting_369568 | chr12_69245976_+ | SINE | Alu | Name=AluSz |
| ADediting_369569 | chr12_69245981_+ | SINE | Alu | Name=AluSz |
| ADediting_369570 | chr12_69245996_+ | SINE | Alu | Name=AluSz |
| ADediting_369571 | chr12_69245998_+ | SINE | Alu | Name=AluSz |
| ADediting_369572 | chr12_69246007_+ | SINE | Alu | Name=AluSz |
| ADediting_369573 | chr12_69246008_+ | SINE | Alu | Name=AluSz |
| ADediting_369574 | chr12_69246019_+ | SINE | Alu | Name=AluSz |
| ADediting_369575 | chr12_69246028_+ | SINE | Alu | Name=AluSz |
| ADediting_369576 | chr12_69246042_+ | SINE | Alu | Name=AluSz |
| ADediting_369577 | chr12_69246873_+ | SINE | Alu | Name=AluJo |
| ADediting_369578 | chr12_69248992_+ | SINE | Alu | Name=AluYf1 |
| ADediting_369579 | chr12_69250666_+ | SINE | Alu | Name=AluSz |
| ADediting_369580 | chr12_69250672_+ | SINE | Alu | Name=AluSz |
| ADediting_369581 | chr12_69250703_+ | SINE | Alu | Name=AluSz |
| ADediting_369582 | chr12_69250708_+ | SINE | Alu | Name=AluSz |
| ADediting_369583 | chr12_69250740_+ | SINE | Alu | Name=AluSz |
| ADediting_369584 | chr12_69250746_+ | SINE | Alu | Name=AluSz |
| ADediting_369585 | chr12_69250747_+ | SINE | Alu | Name=AluSz |
| ADediting_369586 | chr12_69250764_+ | SINE | Alu | Name=AluSz |
| ADediting_369587 | chr12_69250776_+ | SINE | Alu | Name=AluSz |
| ADediting_369588 | chr12_69250827_+ | SINE | Alu | Name=AluSz |
| ADediting_369589 | chr12_69250836_+ | SINE | Alu | Name=AluSz |
| ADediting_369590 | chr12_69250881_+ | SINE | Alu | Name=AluSz |
| ADediting_369591 | chr12_69250882_+ | SINE | Alu | Name=AluSz |
| ADediting_369592 | chr12_69250920_+ | SINE | Alu | Name=AluSz |
| ADediting_369593 | chr12_69250936_+ | SINE | Alu | Name=AluSz |
| ADediting_369594 | chr12_69255041_+ | LINE | L1 | Name=L1MB7 |
| ADediting_369595 | chr12_69255048_+ | LINE | L1 | Name=L1MB7 |
| ADediting_369596 | chr12_69255297_+ | LINE | L1 | Name=L1MB7 |
| ADediting_369597 | chr12_69255971_+ | LINE | L1 | Name=L1MB8 |
| ADediting_369598 | chr12_69255980_+ | LINE | L1 | Name=L1MB8 |
| ADediting_369599 | chr12_69256050_+ | LINE | L1 | Name=L1MB8 |
| ADediting_369600 | chr12_69256051_+ | LINE | L1 | Name=L1MB8 |
| ADediting_369601 | chr12_69256052_+ | LINE | L1 | Name=L1MB8 |
| ADediting_369603 | chr12_69260851_+ | SINE | Alu | Name=FLAM_C |
| ADediting_369604 | chr12_69260852_+ | SINE | Alu | Name=FLAM_C |
| ADediting_369605 | chr12_69260909_+ | SINE | Alu | Name=FLAM_C |
| ADediting_369606 | chr12_69261347_+ | SINE | Alu | Name=AluJb |
| ADediting_1533920 | chr12_69242854_+ | SINE | Alu | Name=AluSz |
| ADediting_1533921 | chr12_69242862_+ | SINE | Alu | Name=AluSz |
| ADediting_1533922 | chr12_69242870_+ | SINE | Alu | Name=AluSz |
| ADediting_1533923 | chr12_69243013_+ | SINE | Alu | Name=AluSz |
| ADediting_1533924 | chr12_69244588_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1533925 | chr12_69245931_+ | SINE | Alu | Name=AluSz |
| ADediting_1533926 | chr12_69255069_+ | LINE | L1 | Name=L1MB7 |
| ADediting_1533927 | chr12_69255124_+ | LINE | L1 | Name=L1MB7 |
| ADediting_1533928 | chr12_69255126_+ | LINE | L1 | Name=L1MB7 |
| ADediting_1533929 | chr12_69255131_+ | LINE | L1 | Name=L1MB7 |
| ADediting_1533930 | chr12_69255136_+ | LINE | L1 | Name=L1MB7 |
| ADediting_1533931 | chr12_69255137_+ | LINE | L1 | Name=L1MB7 |
| ADediting_1533932 | chr12_69255145_+ | LINE | L1 | Name=L1MB7 |
| ADediting_1533933 | chr12_69255172_+ | LINE | L1 | Name=L1MB7 |
| ADediting_1533934 | chr12_69255187_+ | LINE | L1 | Name=L1MB7 |
| ADediting_1533935 | chr12_69255214_+ | LINE | L1 | Name=L1MB7 |
| ADediting_1533936 | chr12_69255227_+ | LINE | L1 | Name=L1MB7 |
| ADediting_1533937 | chr12_69256102_+ | LINE | L1 | Name=L1MB8 |
| ADediting_1533938 | chr12_69256107_+ | LINE | L1 | Name=L1MB8 |
| ADediting_1533939 | chr12_69256108_+ | LINE | L1 | Name=L1MB8 |
| ADediting_1533940 | chr12_69256123_+ | LINE | L1 | Name=L1MB8 |
| ADediting_1533941 | chr12_69256139_+ | LINE | L1 | Name=L1MB8 |
| ADediting_1533942 | chr12_69256151_+ | LINE | L1 | Name=L1MB8 |
| ADediting_1533943 | chr12_69256157_+ | LINE | L1 | Name=L1MB8 |
| ADediting_1533944 | chr12_69256158_+ | LINE | L1 | Name=L1MB8 |
| ADediting_1533945 | chr12_69256226_+ | LINE | L1 | Name=L1MB8 |
| ADediting_1533946 | chr12_69261338_+ | SINE | Alu | Name=AluJb |
| ADediting_1614702 | chr12_69242853_+ | SINE | Alu | Name=AluSz |
| ADediting_1614703 | chr12_69243010_+ | SINE | Alu | Name=AluSz |
| ADediting_1614704 | chr12_69243035_+ | SINE | Alu | Name=AluSz |
| ADediting_1614705 | chr12_69245935_+ | SINE | Alu | Name=AluSz |
| ADediting_1614706 | chr12_69250844_+ | SINE | Alu | Name=AluSz |
| ADediting_1614707 | chr12_69255000_+ | LINE | L1 | Name=L1MB7 |
| ADediting_1614708 | chr12_69255186_+ | LINE | L1 | Name=L1MB7 |
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RNA A-to-I editing events in the alternative splicing sites for CPSF6 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| A5SS | ADediting_369594 | chr12_69255041_+ | 69255035:69255043 | 5ss | 4i | CTGGTTAGC | 2.22 | CTGGTTGGC | 1.14 |
| ES | ADediting_1614707 | chr12_69255000_+ | 69254982:69255004 | 3ss | 2i | TTACCACTGTCTCATTCCAGAAC | 10.26 | TTACCACTGTCTCATTCCGGAAC | 2.30 |
| ES | ADediting_369594 | chr12_69255041_+ | 69255035:69255043 | 5ss | 4i | CTGGTTAGC | 2.22 | CTGGTTGGC | 1.14 |
| ES | ADediting_369594 | chr12_69255041_+ | 69255035:69255043 | 5ss | 4i | CTGGTTAGC | 2.22 | CTGGTTGGC | 1.14 |
| ES | ADediting_369599 | chr12_69256050_+ | 69256050:69256058 | 5ss | 3e | AAAGTAAGT | 9.72 | GAAGTAAGT | 9.82 |
| ES | ADediting_369599 | chr12_69256050_+ | 69256050:69256058 | 5ss | 3e | AAAGTAAGT | 9.72 | GAAGTAAGT | 9.82 |
| ES | ADediting_369599 | chr12_69256050_+ | 69256050:69256058 | 5ss | 3e | AAAGTAAGT | 9.72 | GAAGTAAGT | 9.82 |
| ES | ADediting_369600 | chr12_69256051_+ | 69256050:69256058 | 5ss | 2e | AAAGTAAGT | 9.72 | AGAGTAAGT | 9.35 |
| ES | ADediting_369600 | chr12_69256051_+ | 69256050:69256058 | 5ss | 2e | AAAGTAAGT | 9.72 | AGAGTAAGT | 9.35 |
| ES | ADediting_369601 | chr12_69256052_+ | 69256050:69256058 | 5ss | 1e | AAAGTAAGT | 9.72 | AAGGTAAGT | 11.00 |
| ES | ADediting_369601 | chr12_69256052_+ | 69256050:69256058 | 5ss | 1e | AAAGTAAGT | 9.72 | AAGGTAAGT | 11.00 |
| ES | ADediting_369601 | chr12_69256052_+ | 69256050:69256058 | 5ss | 1e | AAAGTAAGT | 9.72 | AAGGTAAGT | 11.00 |
| ES | ADediting_369601 | chr12_69256052_+ | 69256050:69256058 | 5ss | 1e | AAAGTAAGT | 9.72 | AAGGTAAGT | 11.00 |
| ME1 | ADediting_369594 | chr12_69255041_+ | 69255035:69255043 | 5ss | 4i | CTGGTTAGC | 2.22 | CTGGTTGGC | 1.14 |
| ME2 | ADediting_369601 | chr12_69256052_+ | 69256050:69256058 | 5ss | 1e | AAAGTAAGT | 9.72 | AAGGTAAGT | 11.00 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CPSF6 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for CPSF6 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for CPSF6 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1533926 | chr12_69255069_+ | ENSG00000111605.18 | ENST00000550987.5 | CPSF6-206 | hsa-miR-1324 | chr12 | 69255067 | 69255073 | 7mer-m8 | 69255051 | 69255074 | 142 | -10.43 |
| ADediting_1533926 | chr12_69255069_+ | ENSG00000111605.18 | ENST00000550987.5 | CPSF6-206 | hsa-miR-3166 | chr12 | 69255068 | 69255074 | 7mer-m8 | 69255053 | 69255075 | 140 | -11.83 |
| ADediting_1533926 | chr12_69255069_+ | ENSG00000111605.18 | ENST00000550987.5 | CPSF6-206 | hsa-miR-4524b-3p | chr12 | 69255066 | 69255072 | 7mer-m8 | 69255054 | 69255073 | 140 | -11.16 |
| ADediting_1533927 | chr12_69255124_+ | ENSG00000111605.18 | ENST00000550987.5 | CPSF6-206 | hsa-miR-1245b-3p | chr12 | 69255118 | 69255125 | 8mer-1a | 69255097 | 69255125 | 145 | -19.62 |
| ADediting_1533927 | chr12_69255124_+ | ENSG00000111605.18 | ENST00000550987.5 | CPSF6-206 | hsa-miR-3942-3p | chr12 | 69255120 | 69255126 | 7mer-m8 | 69255108 | 69255127 | 147 | -8.33 |
| ADediting_1533927 | chr12_69255124_+ | ENSG00000111605.18 | ENST00000550987.5 | CPSF6-206 | hsa-miR-892c-5p | chr12 | 69255121 | 69255127 | 7mer-m8 | 69255106 | 69255128 | 156 | -19.58 |
| ADediting_1533928 | chr12_69255126_+ | ENSG00000111605.18 | ENST00000550987.5 | CPSF6-206 | hsa-miR-4436b-5p | chr12 | 69255124 | 69255131 | 8mer-1a | 69255110 | 69255131 | 140 | -11.47 |
| ADediting_1533929 | chr12_69255131_+ | ENSG00000111605.18 | ENST00000550987.5 | CPSF6-206 | hsa-miR-136-5p | chr12 | 69255125 | 69255131 | 7mer-m8 | 69255112 | 69255132 | 153 | -18.95 |
| ADediting_1533930 | chr12_69255136_+ | ENSG00000111605.18 | ENST00000550987.5 | CPSF6-206 | hsa-miR-433-3p | chr12 | 69255131 | 69255138 | 8mer-1a | 69255117 | 69255138 | 140 | -12.34 |
| ADediting_1533931 | chr12_69255137_+ | ENSG00000111605.18 | ENST00000550987.5 | CPSF6-206 | hsa-miR-630 | chr12 | 69255136 | 69255142 | 7mer-m8 | 69255122 | 69255143 | 146 | -11.78 |
| ADediting_1533931 | chr12_69255137_+ | ENSG00000111605.18 | ENST00000550987.5 | CPSF6-206 | hsa-miR-7159-3p | chr12 | 69255133 | 69255139 | 7mer-m8 | 69255119 | 69255140 | 151 | -10.31 |
| ADediting_369594 | chr12_69255041_+ | ENSG00000111605.18 | ENST00000550987.5 | CPSF6-206 | hsa-miR-5189-3p | chr12 | 69255037 | 69255044 | 8mer-1a | 69255022 | 69255044 | 142 | -19.7 |
| ADediting_369595 | chr12_69255048_+ | ENSG00000111605.18 | ENST00000550987.5 | CPSF6-206 | hsa-miR-6090 | chr12 | 69255047 | 69255054 | 8mer-1a | 69255036 | 69255054 | 145 | -20.52 |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1533932 | chr12_69255145_+ | ENSG00000111605.18 | ENST00000550987.5 | CPSF6-206 | hsa-miR-4759 | chr12 | 69255144 | 69255151 | 8mer-1a | 69255131 | 69255151 | 150 | -14.42 |
| ADediting_369595 | chr12_69255048_+ | ENSG00000111605.18 | ENST00000550987.5 | CPSF6-206 | hsa-miR-1236-5p | chr12 | 69255045 | 69255051 | 7mer-m8 | 69255032 | 69255052 | 146 | -16.06 |
| ADediting_369595 | chr12_69255048_+ | ENSG00000111605.18 | ENST00000550987.5 | CPSF6-206 | hsa-miR-3118 | chr12 | 69255043 | 69255049 | 7mer-m8 | 69255026 | 69255050 | 150 | -15.58 |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000111605.18 | ENST00000435070.7 | CPSF6-202 | hsa-miR-5688 | chr12 | 69273255 | 69273261 | 7mer-m8 | 69273245 | 69273262 | 146 | -11.27 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000111605.18 | ENST00000435070.7 | CPSF6-202 | hsa-miR-381-3p | chr12 | 69271873 | 69271880 | 8mer-1a | 69271858 | 69271880 | 155 | -21.8 |
| ADediting_286380 | chr11_79422188_- | ENSG00000111605.18 | ENST00000435070.7 | CPSF6-202 | hsa-miR-5579-3p | chr12 | 69270484 | 69270490 | 7mer-m8 | 69270468 | 69270491 | 171 | -22.44 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000111605.18 | ENST00000435070.7 | CPSF6-202 | hsa-miR-381-3p | chr12 | 69274324 | 69274330 | 7mer-m8 | 69274308 | 69274331 | 146 | -11.67 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000111605.18 | ENST00000435070.7 | CPSF6-202 | hsa-miR-381-3p | chr12 | 69274324 | 69274330 | 7mer-m8 | 69274308 | 69274331 | 146 | -11.67 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000111605.18 | ENST00000435070.7 | CPSF6-202 | hsa-miR-641 | chr12 | 69273373 | 69273379 | 7mer-m8 | 69273356 | 69273380 | 148 | -13.56 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000111605.18 | ENST00000435070.7 | CPSF6-202 | hsa-miR-641 | chr12 | 69273373 | 69273379 | 7mer-m8 | 69273356 | 69273380 | 148 | -13.56 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000111605.18 | ENST00000435070.7 | CPSF6-202 | hsa-miR-1273h-3p | chr12 | 69270642 | 69270648 | 7mer-m8 | 69270628 | 69270649 | 147 | -15.76 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000111605.18 | ENST00000435070.7 | CPSF6-202 | hsa-miR-4775 | chr12 | 69271088 | 69271094 | 7mer-m8 | 69271074 | 69271095 | 142 | -5.97 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for CPSF6 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000550987.5 | lncRNA |  |  |
| ENST00000435070.7 | protein_coding |  |  |
| ENST00000266679.8 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_369602 | ENST00000435070.7 | chr12_69257815_+ | 682 | -1725.10 | -1720.90 | -1725.10 |
| ADediting_369602 | ENST00000266679.8 | chr12_69257815_+ | 635 | -678.20 | -672.30 | -678.20 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_369594 | ENST00000550987.5 | chr12_69255041_+ | 441 | -143.00 | -143.50 | -151.10 |
| ADediting_369595 | ENST00000550987.5 | chr12_69255048_+ | 448 | -144.00 | -143.50 | -151.10 |
| ADediting_1533926 | ENST00000550987.5 | chr12_69255069_+ | 469 | -143.50 | -143.50 | -151.10 |
| ADediting_1533927 | ENST00000550987.5 | chr12_69255124_+ | 524 | -143.50 | -143.50 | -151.10 |
| ADediting_1533928 | ENST00000550987.5 | chr12_69255126_+ | 526 | -143.80 | -143.50 | -151.10 |
| ADediting_1533929 | ENST00000550987.5 | chr12_69255131_+ | 531 | -146.10 | -143.50 | -151.10 |
| ADediting_1533930 | ENST00000550987.5 | chr12_69255136_+ | 536 | -143.90 | -143.50 | -151.10 |
| ADediting_1533931 | ENST00000550987.5 | chr12_69255137_+ | 537 | -149.40 | -143.50 | -151.10 |
| ADediting_1533932 | ENST00000550987.5 | chr12_69255145_+ | 545 | -147.10 | -143.50 | -151.10 |
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Relation with ADAR for CPSF6 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| STG | ADediting_369541 | chr12_69243973_+ | 0.245853469928877 | 0.128015141070755 | 0.157323634412222 | 0.155684468674261 | 0.00419821726800941 | 0.309300956944912 |
| CER | ADediting_369603 | chr12_69260851_+ | 1.41748718052941e-13 | 0.556538459404398 | 1.58482286984313e-10 | 0.492194868000982 | 0.037281547445167 | 0.170229934148428 |
| CER | ADediting_369606 | chr12_69261347_+ | 8.09104861461861e-05 | 0.316185984758593 | 0.000588414636388801 | 0.277413735954642 | 0.0579813586776971 | 0.155153794808309 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 2.61909180566385e-73 | 0.809811357799197 | 2.78686057838804e-50 | 0.717429451466027 | 0.95551247537918 | -0.00318126205012336 |
| AC | 6.5013494510689e-65 | 0.830315842684954 | 9.72952127903097e-42 | 0.723136389147757 | 3.18234841125487e-10 | 0.384333694524226 |
| PCC | 1.10028387861439e-57 | 0.862061586655712 | 6.10274609352127e-44 | 0.800784505120455 | 0.000238636604640148 | 0.26288681456758 |
| CER | 1.0827665698687e-52 | 0.891271438135826 | 5.01566663168627e-33 | 0.788309228897143 | 0.0111865623236371 | 0.206618557390615 |
| TCX | 3.59623550788316e-55 | 0.899780274061218 | 2.39581482403936e-14 | 0.570874390523376 | 0.000315434535182319 | 0.290197482651008 |
| FP | 2.66853989923188e-41 | 0.802346252875229 | 2.15816561319996e-36 | 0.771441933861694 | 0.00214917854599598 | 0.228574001986875 |
| IFG | 2.48004816543926e-10 | 0.91121046833114 | 2.99265768901211e-06 | 0.787472011633967 | 0.15654057094103 | 0.292091140232141 |
| PG | 6.26714769888048e-61 | 0.878497044327099 | 2.63680258872931e-37 | 0.767026474446476 | 0.920631073269398 | -0.00735535872613046 |
| STG | 4.04631473051813e-24 | 0.84610418978092 | 2.01268657277451e-18 | 0.780713947633209 | 0.766066190114295 | 0.0329474379432638 |
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Relation with AD stages for CPSF6 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| IFG | ADediting_369537 | chr12_69243937_+ | 0.0353488225216572 | 0.42255826357712 |
| IFG | ADediting_369541 | chr12_69243973_+ | 0.0353488225216572 | 0.42255826357712 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 5.97101917366232e-06 | 0.420197411398553 |
| TCX | 1.08610778590385e-05 | 0.412960127993578 |
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RelatedDrugs for CPSF6 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CPSF6 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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