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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for DSTN |
 Gene summary |
| Gene information | Gene symbol | DSTN | Gene ID | 11034 |
| Gene name | destrin, actin depolymerizing factor | |
| Synonyms | ACTDP|ADF|HEL32|bA462D18.2 | |
| Cytomap | 20p12.1 | |
| Type of gene | protein-coding | |
| Description | destrinactin-depolymerizing factorbA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP))epididymis luminal protein 32epididymis secretory sperm binding protein | |
| Modification date | 20200327 | |
| UniProtAcc | P60981, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| DSTN | GO:0030042 | actin filament depolymerization | 11812157 |
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RNA A-to-I events for DSTN |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_914140(17573938, +), ADediting_914141(17573950, +), ADediting_914142(17573971, +), ADediting_914143(17574014, +), ADediting_914144(17574016, +), ADediting_914145(17574018, +), ADediting_914146(17574040, +), ADediting_914147(17574041, +), ADediting_914148(17574057, +), ADediting_914149(17574081, +), ADediting_914150(17574153, +), ADediting_914151(17574606, +), ADediting_914152(17574611, +), ADediting_914153(17574969, +), ADediting_914154(17574996, +), ADediting_914155(17575061, +), ADediting_914156(17575775, +), ADediting_914157(17580663, +), ADediting_914158(17581299, +), ADediting_914159(17581387, +), ADediting_914160(17582137, +), ADediting_914161(17582172, +), ADediting_914162(17582179, +), ADediting_914163(17582353, +), ADediting_914164(17583837, +), ADediting_914165(17583849, +), ADediting_914166(17583929, +), ADediting_914167(17583974, +), ADediting_914168(17583992, +), ADediting_914169(17584001, +), ADediting_914170(17584421, +), ADediting_914171(17584531, +), ADediting_914172(17584532, +), ADediting_914173(17584558, +), ADediting_914174(17584587, +), ADediting_914175(17587290, +), ADediting_914176(17587353, +), ADediting_914177(17587392, +), ADediting_914178(17587402, +), ADediting_914179(17588508, +), ADediting_914180(17589457, +), ADediting_914181(17608375, +), ADediting_914182(17608401, +), ADediting_914183(17608402, +), ADediting_914184(17608404, +), ADediting_914185(17608509, +), ADediting_914186(17608545, +), ADediting_914187(17608568, +), ADediting_914188(17608588, +), ADediting_914189(17608605, +), ADediting_914190(17608606, +), ADediting_914191(17609223, +), ADediting_914192(17609225, +), ADediting_914193(17609227, +), ADediting_914194(17609235, +), ADediting_914195(17609247, +), ADediting_914196(17609252, +), ADediting_914197(17609274, +), ADediting_914198(17609307, +), ADediting_914199(17609330, +), ADediting_914200(17609331, +), ADediting_914201(17609343, +), ADediting_1565220(17608391, +), ADediting_1565221(17609308, +), ADediting_1639986(17574986, +), ADediting_1639987(17575006, +), ADediting_1639988(17575121, +), ADediting_1639989(17575550, +), ADediting_1639990(17575579, +), ADediting_1639991(17589304, +), |
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RNA editing positional annotations for DSTN using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_914140 | chr20_17573938_+ | intronic |
| ADediting_914141 | chr20_17573950_+ | intronic |
| ADediting_914142 | chr20_17573971_+ | intronic |
| ADediting_914143 | chr20_17574014_+ | intronic |
| ADediting_914144 | chr20_17574016_+ | intronic |
| ADediting_914145 | chr20_17574018_+ | intronic |
| ADediting_914146 | chr20_17574040_+ | intronic |
| ADediting_914147 | chr20_17574041_+ | intronic |
| ADediting_914148 | chr20_17574057_+ | intronic |
| ADediting_914149 | chr20_17574081_+ | intronic |
| ADediting_914150 | chr20_17574153_+ | intronic |
| ADediting_914151 | chr20_17574606_+ | intronic |
| ADediting_914152 | chr20_17574611_+ | intronic |
| ADediting_914153 | chr20_17574969_+ | intronic |
| ADediting_914154 | chr20_17574996_+ | intronic |
| ADediting_914155 | chr20_17575061_+ | intronic |
| ADediting_914156 | chr20_17575775_+ | intronic |
| ADediting_914157 | chr20_17580663_+ | intronic |
| ADediting_914158 | chr20_17581299_+ | intronic |
| ADediting_914159 | chr20_17581387_+ | intronic |
| ADediting_914160 | chr20_17582137_+ | intronic |
| ADediting_914161 | chr20_17582172_+ | intronic |
| ADediting_914162 | chr20_17582179_+ | intronic |
| ADediting_914163 | chr20_17582353_+ | intronic |
| ADediting_914164 | chr20_17583837_+ | intronic |
| ADediting_914165 | chr20_17583849_+ | intronic |
| ADediting_914166 | chr20_17583929_+ | intronic |
| ADediting_914167 | chr20_17583974_+ | intronic |
| ADediting_914168 | chr20_17583992_+ | intronic |
| ADediting_914169 | chr20_17584001_+ | intronic |
| ADediting_914170 | chr20_17584421_+ | intronic |
| ADediting_914171 | chr20_17584531_+ | intronic |
| ADediting_914172 | chr20_17584532_+ | intronic |
| ADediting_914173 | chr20_17584558_+ | intronic |
| ADediting_914174 | chr20_17584587_+ | intronic |
| ADediting_914175 | chr20_17587290_+ | intronic |
| ADediting_914176 | chr20_17587353_+ | intronic |
| ADediting_914177 | chr20_17587392_+ | intronic |
| ADediting_914178 | chr20_17587402_+ | intronic |
| ADediting_914179 | chr20_17588508_+ | intronic |
| ADediting_914180 | chr20_17589457_+ | intronic |
| ADediting_914181 | chr20_17608375_+ | UTR3 |
| ADediting_914182 | chr20_17608401_+ | UTR3 |
| ADediting_914183 | chr20_17608402_+ | UTR3 |
| ADediting_914184 | chr20_17608404_+ | UTR3 |
| ADediting_914185 | chr20_17608509_+ | UTR3 |
| ADediting_914186 | chr20_17608545_+ | UTR3 |
| ADediting_914187 | chr20_17608568_+ | UTR3 |
| ADediting_914188 | chr20_17608588_+ | UTR3 |
| ADediting_914189 | chr20_17608605_+ | UTR3 |
| ADediting_914190 | chr20_17608606_+ | UTR3 |
| ADediting_914191 | chr20_17609223_+ | UTR3 |
| ADediting_914192 | chr20_17609225_+ | UTR3 |
| ADediting_914193 | chr20_17609227_+ | UTR3 |
| ADediting_914194 | chr20_17609235_+ | UTR3 |
| ADediting_914195 | chr20_17609247_+ | UTR3 |
| ADediting_914196 | chr20_17609252_+ | UTR3 |
| ADediting_914197 | chr20_17609274_+ | UTR3 |
| ADediting_914198 | chr20_17609307_+ | UTR3 |
| ADediting_914199 | chr20_17609330_+ | UTR3 |
| ADediting_914200 | chr20_17609331_+ | UTR3 |
| ADediting_914201 | chr20_17609343_+ | UTR3 |
| ADediting_1565220 | chr20_17608391_+ | UTR3 |
| ADediting_1565221 | chr20_17609308_+ | UTR3 |
| ADediting_1639986 | chr20_17574986_+ | intronic |
| ADediting_1639987 | chr20_17575006_+ | intronic |
| ADediting_1639988 | chr20_17575121_+ | intronic |
| ADediting_1639989 | chr20_17575550_+ | intronic |
| ADediting_1639990 | chr20_17575579_+ | intronic |
| ADediting_1639991 | chr20_17589304_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_914140 | chr20_17573938_+ | SINE | Alu | Name=AluJr |
| ADediting_914141 | chr20_17573950_+ | SINE | Alu | Name=AluJr |
| ADediting_914142 | chr20_17573971_+ | SINE | Alu | Name=AluJr |
| ADediting_914143 | chr20_17574014_+ | SINE | Alu | Name=AluJr |
| ADediting_914144 | chr20_17574016_+ | SINE | Alu | Name=AluJr |
| ADediting_914145 | chr20_17574018_+ | SINE | Alu | Name=AluJr |
| ADediting_914146 | chr20_17574040_+ | SINE | Alu | Name=AluJr |
| ADediting_914147 | chr20_17574041_+ | SINE | Alu | Name=AluJr |
| ADediting_914148 | chr20_17574057_+ | SINE | Alu | Name=AluJr |
| ADediting_914149 | chr20_17574081_+ | SINE | Alu | Name=AluJr |
| ADediting_914150 | chr20_17574153_+ | SINE | Alu | Name=AluJr |
| ADediting_914151 | chr20_17574606_+ | SINE | Alu | Name=AluSx |
| ADediting_914152 | chr20_17574611_+ | SINE | Alu | Name=AluSx |
| ADediting_914153 | chr20_17574969_+ | SINE | Alu | Name=AluJr |
| ADediting_914154 | chr20_17574996_+ | SINE | Alu | Name=AluJr |
| ADediting_914155 | chr20_17575061_+ | SINE | Alu | Name=AluJr |
| ADediting_914156 | chr20_17575775_+ | SINE | Alu | Name=AluJb |
| ADediting_914157 | chr20_17580663_+ | SINE | Alu | Name=AluSq2 |
| ADediting_914158 | chr20_17581299_+ | SINE | Alu | Name=AluJr4 |
| ADediting_914159 | chr20_17581387_+ | SINE | Alu | Name=AluJr4 |
| ADediting_914160 | chr20_17582137_+ | SINE | Alu | Name=AluSx3 |
| ADediting_914161 | chr20_17582172_+ | SINE | Alu | Name=AluSx3 |
| ADediting_914162 | chr20_17582179_+ | SINE | Alu | Name=AluSx3 |
| ADediting_914163 | chr20_17582353_+ | SINE | Alu | Name=AluSx3 |
| ADediting_914164 | chr20_17583837_+ | SINE | Alu | Name=AluJr |
| ADediting_914165 | chr20_17583849_+ | SINE | Alu | Name=AluJr |
| ADediting_914166 | chr20_17583929_+ | SINE | Alu | Name=AluJr |
| ADediting_914167 | chr20_17583974_+ | SINE | Alu | Name=AluJr |
| ADediting_914168 | chr20_17583992_+ | SINE | Alu | Name=AluJr |
| ADediting_914169 | chr20_17584001_+ | SINE | Alu | Name=AluJr |
| ADediting_914170 | chr20_17584421_+ | SINE | Alu | Name=AluSp |
| ADediting_914171 | chr20_17584531_+ | SINE | Alu | Name=AluSp |
| ADediting_914172 | chr20_17584532_+ | SINE | Alu | Name=AluSp |
| ADediting_914173 | chr20_17584558_+ | SINE | Alu | Name=AluSp |
| ADediting_914174 | chr20_17584587_+ | SINE | Alu | Name=AluSp |
| ADediting_914175 | chr20_17587290_+ | SINE | Alu | Name=AluJb |
| ADediting_914176 | chr20_17587353_+ | SINE | Alu | Name=AluJb |
| ADediting_914177 | chr20_17587392_+ | SINE | Alu | Name=AluJb |
| ADediting_914178 | chr20_17587402_+ | SINE | Alu | Name=AluJb |
| ADediting_914179 | chr20_17588508_+ | SINE | Alu | Name=AluY |
| ADediting_914180 | chr20_17589457_+ | SINE | Alu | Name=AluSx |
| ADediting_914181 | chr20_17608375_+ | SINE | Alu | Name=AluJr |
| ADediting_914182 | chr20_17608401_+ | SINE | Alu | Name=AluJr |
| ADediting_914183 | chr20_17608402_+ | SINE | Alu | Name=AluJr |
| ADediting_914184 | chr20_17608404_+ | SINE | Alu | Name=AluJr |
| ADediting_914185 | chr20_17608509_+ | SINE | Alu | Name=AluJr |
| ADediting_914186 | chr20_17608545_+ | SINE | Alu | Name=AluJr |
| ADediting_914187 | chr20_17608568_+ | SINE | Alu | Name=AluJr |
| ADediting_914188 | chr20_17608588_+ | SINE | Alu | Name=AluJr |
| ADediting_914189 | chr20_17608605_+ | SINE | Alu | Name=AluJr |
| ADediting_914190 | chr20_17608606_+ | SINE | Alu | Name=AluJr |
| ADediting_914191 | chr20_17609223_+ | SINE | Alu | Name=AluJo |
| ADediting_914192 | chr20_17609225_+ | SINE | Alu | Name=AluJo |
| ADediting_914193 | chr20_17609227_+ | SINE | Alu | Name=AluJo |
| ADediting_914194 | chr20_17609235_+ | SINE | Alu | Name=AluJo |
| ADediting_914195 | chr20_17609247_+ | SINE | Alu | Name=AluJo |
| ADediting_914196 | chr20_17609252_+ | SINE | Alu | Name=AluJo |
| ADediting_914197 | chr20_17609274_+ | SINE | Alu | Name=AluJo |
| ADediting_914198 | chr20_17609307_+ | SINE | Alu | Name=AluJo |
| ADediting_914199 | chr20_17609330_+ | SINE | Alu | Name=AluJo |
| ADediting_914200 | chr20_17609331_+ | SINE | Alu | Name=AluJo |
| ADediting_914201 | chr20_17609343_+ | SINE | Alu | Name=AluJo |
| ADediting_1565220 | chr20_17608391_+ | SINE | Alu | Name=AluJr |
| ADediting_1565221 | chr20_17609308_+ | SINE | Alu | Name=AluJo |
| ADediting_1639986 | chr20_17574986_+ | SINE | Alu | Name=AluJr |
| ADediting_1639987 | chr20_17575006_+ | SINE | Alu | Name=AluJr |
| ADediting_1639988 | chr20_17575121_+ | SINE | Alu | Name=AluJr |
| ADediting_1639989 | chr20_17575550_+ | SINE | Alu | Name=AluJb |
| ADediting_1639990 | chr20_17575579_+ | SINE | Alu | Name=AluJb |
| ADediting_1639991 | chr20_17589304_+ | SINE | Alu | Name=AluSx |
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RNA A-to-I editing events in the alternative splicing sites for DSTN |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for DSTN |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for DSTN |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for DSTN |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1565220 | chr20_17608391_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-10392-3p | chr20 | 17608389 | 17608396 | 8mer-1a | 17608373 | 17608396 | 142 | -22.69 |
| ADediting_1565221 | chr20_17609308_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-3692-5p | chr20 | 17609301 | 17609307 | 7mer-m8 | 17609278 | 17609308 | 156 | -30.68 |
| ADediting_1565221 | chr20_17609308_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-370-3p | chr20 | 17609302 | 17609308 | 7mer-m8 | 17609288 | 17609309 | 156 | -25.23 |
| ADediting_1565221 | chr20_17609308_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-6893-3p | chr20 | 17609302 | 17609308 | 7mer-m8 | 17609288 | 17609309 | 140 | -14.42 |
| ADediting_914181 | chr20_17608375_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-3199 | chr20 | 17608373 | 17608379 | 7mer-1a | 17608360 | 17608379 | 141 | -22.83 |
| ADediting_914183 | chr20_17608402_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-1976 | chr20 | 17608398 | 17608404 | 7mer-m8 | 17608385 | 17608405 | 149 | -25.54 |
| ADediting_914183 | chr20_17608402_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-660-3p | chr20 | 17608399 | 17608406 | 8mer-1a | 17608386 | 17608406 | 143 | -18.48 |
| ADediting_914183 | chr20_17608402_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-6747-3p | chr20 | 17608396 | 17608403 | 8mer-1a | 17608382 | 17608403 | 150 | -24.16 |
| ADediting_914185 | chr20_17608509_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-181a-2-3p | chr20 | 17608503 | 17608509 | 7mer-m8 | 17608490 | 17608510 | 153 | -22.1 |
| ADediting_914187 | chr20_17608568_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-4267 | chr20 | 17608561 | 17608567 | 7mer-m8 | 17608553 | 17608568 | 141 | -17.83 |
| ADediting_914187 | chr20_17608568_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-7977 | chr20 | 17608563 | 17608569 | 7mer-m8 | 17608552 | 17608570 | 145 | -19.06 |
| ADediting_914188 | chr20_17608588_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-4743-5p | chr20 | 17608584 | 17608590 | 7mer-m8 | 17608572 | 17608591 | 152 | -28.17 |
| ADediting_914191 | chr20_17609223_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-4433b-5p | chr20 | 17609220 | 17609226 | 7mer-m8 | 17609207 | 17609227 | 140 | -13.05 |
| ADediting_914192 | chr20_17609225_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-6747-3p | chr20 | 17609222 | 17609228 | 7mer-m8 | 17609209 | 17609229 | 141 | -15.89 |
| ADediting_914192 | chr20_17609225_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-6752-3p | chr20 | 17609223 | 17609229 | 7mer-m8 | 17609210 | 17609230 | 146 | -15.92 |
| ADediting_914193 | chr20_17609227_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-340-3p | chr20 | 17609221 | 17609227 | 7mer-m8 | 17609207 | 17609228 | 146 | -19.58 |
| ADediting_914193 | chr20_17609227_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-6827-3p | chr20 | 17609221 | 17609227 | 7mer-m8 | 17609208 | 17609228 | 140 | -14.58 |
| ADediting_914195 | chr20_17609247_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-3940-3p | chr20 | 17609244 | 17609251 | 8mer-1a | 17609230 | 17609251 | 140 | -14.58 |
| ADediting_914196 | chr20_17609252_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-508-5p | chr20 | 17609249 | 17609255 | 7mer-m8 | 17609232 | 17609256 | 141 | -18.97 |
| ADediting_914196 | chr20_17609252_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-6512-3p | chr20 | 17609247 | 17609253 | 7mer-m8 | 17609233 | 17609254 | 140 | -17.21 |
| ADediting_914196 | chr20_17609252_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-6720-5p | chr20 | 17609247 | 17609253 | 7mer-m8 | 17609233 | 17609254 | 146 | -21.37 |
| ADediting_914196 | chr20_17609252_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-6849-3p | chr20 | 17609246 | 17609253 | 8mer-1a | 17609232 | 17609253 | 147 | -15.97 |
| ADediting_914196 | chr20_17609252_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-766-3p | chr20 | 17609248 | 17609254 | 7mer-m8 | 17609234 | 17609255 | 145 | -17.87 |
| ADediting_914199 | chr20_17609330_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-3059-3p | chr20 | 17609325 | 17609331 | 7mer-m8 | 17609312 | 17609332 | 153 | -20.4 |
| ADediting_914199 | chr20_17609330_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-5684 | chr20 | 17609326 | 17609332 | 7mer-m8 | 17609314 | 17609333 | 140 | -12.42 |
| ADediting_914201 | chr20_17609343_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-4705 | chr20 | 17609336 | 17609342 | 7mer-m8 | 17609324 | 17609343 | 146 | -9.14 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1565220 | chr20_17608391_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-150-5p | chr20 | 17608385 | 17608391 | 7mer-m8 | 17608371 | 17608392 | 140 | -13.58 |
| ADediting_1565220 | chr20_17608391_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-6778-3p | chr20 | 17608387 | 17608393 | 7mer-m8 | 17608375 | 17608394 | 146 | -13.66 |
| ADediting_1565221 | chr20_17609308_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-3188 | chr20 | 17609306 | 17609312 | 7mer-m8 | 17609291 | 17609313 | 147 | -21.19 |
| ADediting_914181 | chr20_17608375_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-10399-5p | chr20 | 17608369 | 17608375 | 7mer-m8 | 17608355 | 17608376 | 148 | -9.71 |
| ADediting_914181 | chr20_17608375_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-6504-3p | chr20 | 17608369 | 17608375 | 7mer-m8 | 17608355 | 17608376 | 153 | -14.48 |
| ADediting_914182 | chr20_17608401_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-3152-5p | chr20 | 17608395 | 17608401 | 7mer-m8 | 17608379 | 17608402 | 153 | -16.3 |
| ADediting_914183 | chr20_17608402_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-3152-5p | chr20 | 17608395 | 17608401 | 7mer-m8 | 17608379 | 17608402 | 153 | -16.3 |
| ADediting_914184 | chr20_17608404_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-9903 | chr20 | 17608402 | 17608408 | 7mer-m8 | 17608391 | 17608409 | 144 | -14.24 |
| ADediting_914185 | chr20_17608509_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-8052 | chr20 | 17608508 | 17608514 | 7mer-1a | 17608492 | 17608514 | 143 | -20.14 |
| ADediting_914186 | chr20_17608545_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-1245a | chr20 | 17608540 | 17608546 | 7mer-m8 | 17608527 | 17608547 | 145 | -18.36 |
| ADediting_914187 | chr20_17608568_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-6787-3p | chr20 | 17608562 | 17608569 | 8mer-1a | 17608550 | 17608569 | 147 | -20.17 |
| ADediting_914188 | chr20_17608588_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-3135b | chr20 | 17608583 | 17608589 | 7mer-m8 | 17608573 | 17608590 | 155 | -29.39 |
| ADediting_914188 | chr20_17608588_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-3652 | chr20 | 17608584 | 17608590 | 7mer-m8 | 17608574 | 17608591 | 145 | -19.5 |
| ADediting_914189 | chr20_17608605_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-431-5p | chr20 | 17608602 | 17608608 | 7mer-m8 | 17608591 | 17608609 | 151 | -17.68 |
| ADediting_914189 | chr20_17608605_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-5691 | chr20 | 17608598 | 17608605 | 8mer-1a | 17608584 | 17608605 | 149 | -19.57 |
| ADediting_914189 | chr20_17608605_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-6805-3p | chr20 | 17608598 | 17608605 | 8mer-1a | 17608583 | 17608605 | 146 | -18.25 |
| ADediting_914190 | chr20_17608606_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-431-5p | chr20 | 17608602 | 17608608 | 7mer-m8 | 17608591 | 17608609 | 151 | -17.68 |
| ADediting_914191 | chr20_17609223_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-371b-5p | chr20 | 17609217 | 17609224 | 8mer-1a | 17609200 | 17609224 | 155 | -16.1 |
| ADediting_914191 | chr20_17609223_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-373-5p | chr20 | 17609217 | 17609224 | 8mer-1a | 17609203 | 17609224 | 140 | -10.37 |
| ADediting_914191 | chr20_17609223_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-616-5p | chr20 | 17609217 | 17609224 | 8mer-1a | 17609203 | 17609224 | 140 | -12.1 |
| ADediting_914192 | chr20_17609225_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-4421 | chr20 | 17609222 | 17609228 | 7mer-m8 | 17609208 | 17609229 | 155 | -16.7 |
| ADediting_914192 | chr20_17609225_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-5699-3p | chr20 | 17609222 | 17609228 | 7mer-m8 | 17609208 | 17609229 | 141 | -16.39 |
| ADediting_914193 | chr20_17609227_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-10a-5p | chr20 | 17609224 | 17609230 | 7mer-m8 | 17609211 | 17609231 | 142 | -12.31 |
| ADediting_914193 | chr20_17609227_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-10b-5p | chr20 | 17609224 | 17609230 | 7mer-m8 | 17609205 | 17609231 | 148 | -15.56 |
| ADediting_914193 | chr20_17609227_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-4421 | chr20 | 17609222 | 17609228 | 7mer-m8 | 17609208 | 17609229 | 155 | -16.7 |
| ADediting_914193 | chr20_17609227_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-4725-5p | chr20 | 17609225 | 17609231 | 7mer-m8 | 17609212 | 17609232 | 140 | -15.96 |
| ADediting_914193 | chr20_17609227_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-504-5p | chr20 | 17609225 | 17609231 | 7mer-m8 | 17609213 | 17609232 | 147 | -18.15 |
| ADediting_914193 | chr20_17609227_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-5699-3p | chr20 | 17609222 | 17609228 | 7mer-m8 | 17609208 | 17609229 | 141 | -16.39 |
| ADediting_914195 | chr20_17609247_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-4665-5p | chr20 | 17609240 | 17609246 | 7mer-m8 | 17609224 | 17609247 | 155 | -27.54 |
| ADediting_914195 | chr20_17609247_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-637 | chr20 | 17609241 | 17609247 | 7mer-m8 | 17609222 | 17609248 | 144 | -26.41 |
| ADediting_914195 | chr20_17609247_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-661 | chr20 | 17609243 | 17609249 | 7mer-m8 | 17609227 | 17609250 | 140 | -17.5 |
| ADediting_914195 | chr20_17609247_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-6852-5p | chr20 | 17609242 | 17609248 | 7mer-m8 | 17609228 | 17609249 | 146 | -20.84 |
| ADediting_914196 | chr20_17609252_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-1251-5p | chr20 | 17609248 | 17609254 | 7mer-m8 | 17609232 | 17609255 | 144 | -15.81 |
| ADediting_914196 | chr20_17609252_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-1287-3p | chr20 | 17609247 | 17609253 | 7mer-m8 | 17609231 | 17609254 | 143 | -19.67 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-337-3p | chr20 | 17607731 | 17607738 | 8mer-1a | 17607717 | 17607738 | 145 | -13.93 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-337-3p | chr20 | 17608275 | 17608281 | 7mer-m8 | 17608262 | 17608282 | 147 | -14.56 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000125868.16 | ENST00000474024.5 | DSTN-203 | hsa-miR-337-3p | chr20 | 17607731 | 17607738 | 8mer-1a | 17607717 | 17607738 | 145 | -13.93 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-5585-3p | chr20 | 17607766 | 17607772 | 7mer-m8 | 17607753 | 17607773 | 154 | -21.69 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000125868.16 | ENST00000474024.5 | DSTN-203 | hsa-miR-5585-3p | chr20 | 17607766 | 17607772 | 7mer-m8 | 17607753 | 17607773 | 154 | -21.69 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1391023 | chr8_140732605_- | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-151a-3p | chr20 | 17609040 | 17609046 | 7mer-m8 | 17609028 | 17609047 | 143 | -17.5 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-641 | chr20 | 17607581 | 17607587 | 7mer-m8 | 17607565 | 17607588 | 154 | -14.37 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000125868.16 | ENST00000474024.5 | DSTN-203 | hsa-miR-641 | chr20 | 17607581 | 17607587 | 7mer-m8 | 17607565 | 17607588 | 154 | -14.37 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-641 | chr20 | 17607581 | 17607587 | 7mer-m8 | 17607565 | 17607588 | 154 | -14.37 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000125868.16 | ENST00000474024.5 | DSTN-203 | hsa-miR-641 | chr20 | 17607581 | 17607587 | 7mer-m8 | 17607565 | 17607588 | 154 | -14.37 |
| ADediting_291761 | chr11_93733708_- | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-1304-3p | chr20 | 17607755 | 17607761 | 7mer-m8 | 17607740 | 17607762 | 142 | -12.98 |
| ADediting_291761 | chr11_93733708_- | ENSG00000125868.16 | ENST00000474024.5 | DSTN-203 | hsa-miR-1304-3p | chr20 | 17607755 | 17607761 | 7mer-m8 | 17607740 | 17607762 | 142 | -12.98 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-4775 | chr20 | 17608476 | 17608482 | 7mer-m8 | 17608460 | 17608483 | 153 | -5.72 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000125868.16 | ENST00000246069.12 | DSTN-201 | hsa-miR-4775 | chr20 | 17608725 | 17608731 | 7mer-m8 | 17608711 | 17608732 | 148 | -2.76 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for DSTN |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000246069.12 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_914181 | ENST00000246069.12 | chr20_17608375_+ | 1861 | -1009.00 | -1009.00 | -1034.30 |
| ADediting_1565220 | ENST00000246069.12 | chr20_17608391_+ | 1877 | -1008.10 | -1009.00 | -1034.30 |
| ADediting_914182 | ENST00000246069.12 | chr20_17608401_+ | 1887 | -1008.30 | -1009.00 | -1034.30 |
| ADediting_914183 | ENST00000246069.12 | chr20_17608402_+ | 1888 | -1015.60 | -1009.00 | -1034.30 |
| ADediting_914184 | ENST00000246069.12 | chr20_17608404_+ | 1890 | -1008.10 | -1009.00 | -1034.30 |
| ADediting_914185 | ENST00000246069.12 | chr20_17608509_+ | 1995 | -1010.00 | -1009.00 | -1034.30 |
| ADediting_914186 | ENST00000246069.12 | chr20_17608545_+ | 2031 | -1008.60 | -1009.00 | -1034.30 |
| ADediting_914187 | ENST00000246069.12 | chr20_17608568_+ | 2054 | -1013.80 | -1009.00 | -1034.30 |
| ADediting_914188 | ENST00000246069.12 | chr20_17608588_+ | 2074 | -1009.00 | -1009.00 | -1034.30 |
| ADediting_914189 | ENST00000246069.12 | chr20_17608605_+ | 2091 | -1013.20 | -1009.00 | -1034.30 |
| ADediting_914190 | ENST00000246069.12 | chr20_17608606_+ | 2092 | -1008.50 | -1009.00 | -1034.30 |
| ADediting_914191 | ENST00000246069.12 | chr20_17609223_+ | 2709 | -1008.10 | -1009.00 | -1034.30 |
| ADediting_914192 | ENST00000246069.12 | chr20_17609225_+ | 2711 | -1008.40 | -1009.00 | -1034.30 |
| ADediting_914193 | ENST00000246069.12 | chr20_17609227_+ | 2713 | -1008.20 | -1009.00 | -1034.30 |
| ADediting_914194 | ENST00000246069.12 | chr20_17609235_+ | 2721 | -1012.60 | -1009.00 | -1034.30 |
| ADediting_914195 | ENST00000246069.12 | chr20_17609247_+ | 2733 | -1008.30 | -1009.00 | -1034.30 |
| ADediting_914196 | ENST00000246069.12 | chr20_17609252_+ | 2738 | -1015.60 | -1009.00 | -1034.30 |
| ADediting_914197 | ENST00000246069.12 | chr20_17609274_+ | 2760 | -1015.70 | -1009.00 | -1034.30 |
| ADediting_914198 | ENST00000246069.12 | chr20_17609307_+ | 2793 | -1010.00 | -1009.00 | -1034.30 |
| ADediting_1565221 | ENST00000246069.12 | chr20_17609308_+ | 2794 | -1009.00 | -1009.00 | -1034.30 |
| ADediting_914199 | ENST00000246069.12 | chr20_17609330_+ | 2816 | -1009.10 | -1009.00 | -1034.30 |
| ADediting_914200 | ENST00000246069.12 | chr20_17609331_+ | 2817 | -1008.60 | -1009.00 | -1034.30 |
| ADediting_914201 | ENST00000246069.12 | chr20_17609343_+ | 2829 | -1009.00 | -1009.00 | -1034.30 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for DSTN |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_914176 | chr20_17587353_+ | 0.214213490820784 | -0.0707417802160131 | 0.0291477296571932 | -0.123922557373968 | 8.65631591640836e-11 | 0.357714494776355 |
| CER | ADediting_914183 | chr20_17608402_+ | 2.29250147753998e-09 | 0.463678342074808 | 2.13533506191795e-06 | 0.375888508507784 | 0.00801801065662386 | 0.215728104144483 |
| TCX | ADediting_914183 | chr20_17608402_+ | 2.21151824503239e-07 | 0.407866373238218 | 2.54411170620809e-12 | 0.531688694284189 | 0.0131437055301888 | -0.202076109188441 |
| TCX | ADediting_914189 | chr20_17608605_+ | 0.00303550706369548 | 0.240469326147159 | 0.000109450067990883 | 0.310620631968326 | 0.410739913112956 | -0.0676533303216307 |
| DLPFC | ADediting_914194 | chr20_17609235_+ | 1.45661259256205e-12 | 0.387762776987662 | 1.21875248935511e-16 | 0.447098737493773 | 0.830184989631484 | 0.0122297042471199 |
| TCX | ADediting_914194 | chr20_17609235_+ | 5.67269810385203e-10 | 0.478910529118694 | 3.33294899840852e-12 | 0.529256828458481 | 0.0289212466636223 | -0.178427205979109 |
| DLPFC | ADediting_914196 | chr20_17609252_+ | 8.70996346393417e-21 | 0.497475231770246 | 2.40122841531683e-26 | 0.554104775098011 | 0.584989347526371 | -0.0311353026247455 |
| CER | ADediting_914196 | chr20_17609252_+ | 6.98713988640229e-09 | 0.450963887593856 | 1.2244014833692e-08 | 0.444361366504 | 0.0700879613081761 | 0.148317091549689 |
| TCX | ADediting_914196 | chr20_17609252_+ | 6.03297030177569e-11 | 0.50189025987716 | 2.36788390611666e-24 | 0.710504925401491 | 0.00165074706378843 | -0.254810929327886 |
| DLPFC | ADediting_914200 | chr20_17609331_+ | 6.33491153762113e-10 | 0.341853166537311 | 4.69659614958818e-09 | 0.324930270471915 | 0.752992666660092 | 0.0179445703179828 |
| AC | ADediting_914200 | chr20_17609331_+ | 7.34984724999846e-06 | 0.27928579283684 | 8.73659833898908e-07 | 0.305130654677075 | 0.976555460262355 | -0.00186799510567402 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 6.39218975072181e-77 | 0.820892514850988 | 1.41456862486909e-71 | 0.804224770144696 | 0.897207775858086 | 0.00736712726188978 |
| AC | 1.07407791186023e-91 | 0.900554586056958 | 2.31489820328792e-62 | 0.821208745552989 | 3.30186074736365e-13 | 0.439117405775608 |
| PCC | 2.13638829038828e-44 | 0.803247808944448 | 1.00769927319477e-46 | 0.815295467239801 | 0.202751397401021 | 0.0925750850441572 |
| CER | 1.43005937654563e-36 | 0.812915110553739 | 6.27270899562856e-22 | 0.682874020493117 | 0.306901561502455 | 0.0839801944439934 |
| TCX | 8.91629469443179e-41 | 0.838039169988251 | 5.98573728675958e-29 | 0.755296466961047 | 0.205682135356355 | -0.103919248646484 |
| FP | 7.41927131215428e-10 | 0.440739360997378 | 4.14271564033685e-15 | 0.544165868660407 | 0.0352736037928145 | -0.157912796847056 |
| IFG | 0.0215626331854774 | 0.457236575774987 | 0.0329530941293203 | 0.427690829863416 | 0.0549088318978557 | -0.3885710320817 |
| PG | 1.75604640980069e-40 | 0.787201314873948 | 1.43815742714685e-31 | 0.724607854280565 | 0.0365243904370505 | -0.15344777277064 |
| STG | 1.26471978550666e-13 | 0.70003569685482 | 2.03029345507448e-16 | 0.750603878885421 | 0.0486690923392194 | -0.215797764061609 |
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Relation with AD stages for DSTN |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for DSTN |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DSTN |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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