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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for SLC38A3 |
 Gene summary |
| Gene information | Gene symbol | SLC38A3 | Gene ID | 10991 |
| Gene name | solute carrier family 38 member 3 | |
| Synonyms | G17|NAT1|SN1|SNAT3 | |
| Cytomap | 3p21.31 | |
| Type of gene | protein-coding | |
| Description | sodium-coupled neutral amino acid transporter 3N-system amino acid transporter 1Na(+)-coupled neutral amino acid transporter 3system N amino acid transporter 1system N1 Na+ and H+-coupled glutamine transporter | |
| Modification date | 20200313 | |
| UniProtAcc | Q99624, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| SLC38A3 | GO:0006867 | asparagine transport | 10823827 |
| SLC38A3 | GO:0006868 | glutamine transport | 10823827 |
| SLC38A3 | GO:0015808 | L-alanine transport | 10823827 |
| SLC38A3 | GO:0015817 | histidine transport | 10823827 |
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RNA A-to-I events for SLC38A3 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1079526(50207346, +), ADediting_1079527(50207376, +), ADediting_1079528(50207378, +), ADediting_1079529(50207379, +), ADediting_1079530(50207408, +), ADediting_1079531(50207415, +), ADediting_1079532(50207427, +), ADediting_1079533(50207444, +), ADediting_1079534(50207448, +), ADediting_1079535(50207457, +), ADediting_1079536(50207527, +), ADediting_1079537(50207592, +), ADediting_1079538(50207595, +), ADediting_1079539(50207600, +), ADediting_1079540(50209386, +), ADediting_1079541(50209393, +), ADediting_1079542(50209394, +), |
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RNA editing positional annotations for SLC38A3 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1079526 | chr3_50207346_+ | UTR5 |
| ADediting_1079527 | chr3_50207376_+ | UTR5 |
| ADediting_1079528 | chr3_50207378_+ | UTR5 |
| ADediting_1079529 | chr3_50207379_+ | UTR5 |
| ADediting_1079530 | chr3_50207408_+ | UTR5 |
| ADediting_1079531 | chr3_50207415_+ | UTR5 |
| ADediting_1079532 | chr3_50207427_+ | UTR5 |
| ADediting_1079533 | chr3_50207444_+ | UTR5 |
| ADediting_1079534 | chr3_50207448_+ | UTR5 |
| ADediting_1079535 | chr3_50207457_+ | UTR5 |
| ADediting_1079536 | chr3_50207527_+ | intronic |
| ADediting_1079537 | chr3_50207592_+ | intronic |
| ADediting_1079538 | chr3_50207595_+ | intronic |
| ADediting_1079539 | chr3_50207600_+ | intronic |
| ADediting_1079540 | chr3_50209386_+ | intronic |
| ADediting_1079541 | chr3_50209393_+ | intronic |
| ADediting_1079542 | chr3_50209394_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1079526 | chr3_50207346_+ | SINE | Alu | Name=AluSz |
| ADediting_1079527 | chr3_50207376_+ | SINE | Alu | Name=AluSz |
| ADediting_1079528 | chr3_50207378_+ | SINE | Alu | Name=AluSz |
| ADediting_1079529 | chr3_50207379_+ | SINE | Alu | Name=AluSz |
| ADediting_1079530 | chr3_50207408_+ | SINE | Alu | Name=AluSz |
| ADediting_1079531 | chr3_50207415_+ | SINE | Alu | Name=AluSz |
| ADediting_1079532 | chr3_50207427_+ | SINE | Alu | Name=AluSz |
| ADediting_1079533 | chr3_50207444_+ | SINE | Alu | Name=AluSz |
| ADediting_1079534 | chr3_50207448_+ | SINE | Alu | Name=AluSz |
| ADediting_1079535 | chr3_50207457_+ | SINE | Alu | Name=AluSz |
| ADediting_1079536 | chr3_50207527_+ | SINE | Alu | Name=AluSz |
| ADediting_1079537 | chr3_50207592_+ | SINE | Alu | Name=AluSz |
| ADediting_1079538 | chr3_50207595_+ | SINE | Alu | Name=AluSz |
| ADediting_1079539 | chr3_50207600_+ | SINE | Alu | Name=AluSz |
| ADediting_1079540 | chr3_50209386_+ | SINE | Alu | Name=AluYm1 |
| ADediting_1079541 | chr3_50209393_+ | SINE | Alu | Name=AluYm1 |
| ADediting_1079542 | chr3_50209394_+ | SINE | Alu | Name=AluYm1 |
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RNA A-to-I editing events in the alternative splicing sites for SLC38A3 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SLC38A3 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for SLC38A3 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for SLC38A3 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1631458 | chr19_40282624_- | ENSG00000188338.15 | ENST00000614032.5 | SLC38A3-206 | hsa-miR-641 | chr3 | 50220308 | 50220314 | 7mer-m8 | 50220292 | 50220315 | 147 | -14.06 |
| ADediting_496066 | chr15_66496985_- | ENSG00000188338.15 | ENST00000614032.5 | SLC38A3-206 | hsa-miR-4512 | chr3 | 50221228 | 50221235 | 8mer-1a | 50221213 | 50221235 | 159 | -27.57 |
| ADediting_98288 | chr1_32086990_+ | ENSG00000188338.15 | ENST00000614032.5 | SLC38A3-206 | hsa-miR-5585-3p | chr3 | 50220199 | 50220205 | 7mer-m8 | 50220185 | 50220206 | 155 | -19.01 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_496066 | chr15_66496985_- | ENSG00000188338.15 | ENST00000614032.5 | SLC38A3-206 | hsa-miR-4512 | chr3 | 50220350 | 50220356 | 7mer-m8 | 50220336 | 50220357 | 140 | -16.65 |
| ADediting_496066 | chr15_66496985_- | ENSG00000188338.15 | ENST00000614032.5 | SLC38A3-206 | hsa-miR-4512 | chr3 | 50220635 | 50220641 | 7mer-m8 | 50220622 | 50220642 | 142 | -12.5 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for SLC38A3 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000610458.4 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1079526 | ENST00000610458.4 | chr3_50207346_+ | 114 | -236.20 | -230.80 | -255.20 |
| ADediting_1079527 | ENST00000610458.4 | chr3_50207376_+ | 144 | -234.30 | -230.80 | -255.20 |
| ADediting_1079528 | ENST00000610458.4 | chr3_50207378_+ | 146 | -232.60 | -230.80 | -255.20 |
| ADediting_1079529 | ENST00000610458.4 | chr3_50207379_+ | 147 | -235.50 | -230.80 | -255.20 |
| ADediting_1079530 | ENST00000610458.4 | chr3_50207408_+ | 176 | -230.70 | -230.80 | -255.20 |
| ADediting_1079531 | ENST00000610458.4 | chr3_50207415_+ | 183 | -234.50 | -230.80 | -255.20 |
| ADediting_1079532 | ENST00000610458.4 | chr3_50207427_+ | 195 | -230.90 | -230.80 | -255.20 |
| ADediting_1079533 | ENST00000610458.4 | chr3_50207444_+ | 212 | -234.10 | -230.80 | -255.20 |
| ADediting_1079534 | ENST00000610458.4 | chr3_50207448_+ | 216 | -231.00 | -230.80 | -255.20 |
| ADediting_1079535 | ENST00000610458.4 | chr3_50207457_+ | 225 | -233.60 | -230.80 | -255.20 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for SLC38A3 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_1079526 | chr3_50207346_+ | 0.0124777594793693 | 0.141751422360291 | 0.882679593516972 | -0.00841544344272969 | 5.23400311806882e-09 | 0.323984956804348 |
| DLPFC | ADediting_1079530 | chr3_50207408_+ | 0.104862603550797 | 0.0922838528899544 | 0.698374732972813 | -0.0220959670769178 | 1.09594966298152e-11 | 0.373304567361732 |
| DLPFC | ADediting_1079532 | chr3_50207427_+ | 0.2560155121489 | 0.0647062353729102 | 0.124474157334633 | -0.0874398510002808 | 3.62157275122528e-09 | 0.327185144302283 |
| TCX | ADediting_1079532 | chr3_50207427_+ | 0.40439642527274 | 0.0685725474528272 | 0.193388316418798 | -0.10678462307294 | 6.21377060370605e-05 | 0.320960852777636 |
| TCX | ADediting_1079533 | chr3_50207444_+ | 0.220202067707162 | 0.100689447161448 | 0.221880572433104 | -0.100325970903584 | 0.000125211771791509 | 0.308106478250524 |
| DLPFC | ADediting_1079534 | chr3_50207448_+ | 0.00354039636136401 | 0.165171290470229 | 0.330231251383266 | -0.0554810264442914 | 1.1402149103202e-19 | 0.48470030980184 |
| DLPFC | ADediting_1079535 | chr3_50207457_+ | 0.0250212313531612 | 0.127280567049839 | 0.465535634760526 | -0.0415978015009851 | 2.04308463565071e-12 | 0.385387894487437 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 2.67650894942751e-05 | 0.236082354652297 | 0.000217389739169996 | 0.20855508729609 | 3.54503005571825e-18 | 0.466748850679329 |
| AC | 4.99628218363136e-36 | 0.685407135244243 | 1.7222357723892e-18 | 0.517022265562884 | 1.19775028066047e-23 | 0.577624011186848 |
| PCC | 0.0041828476019896 | 0.206353577414685 | 0.101928594851947 | 0.118706448172334 | 8.2157617900151e-08 | 0.376130207253114 |
| CER | 0.51607786968355 | 0.0534326314767196 | 0.107583597858605 | -0.131915227247388 | 5.58417955425718e-07 | 0.395207061015478 |
| TCX | 0.171360442487614 | 0.112269877477303 | 0.00250960564049774 | -0.245036671131214 | 6.56029913506401e-07 | 0.392950697140272 |
| FP | 0.0538789747421551 | 0.144753209176444 | 0.300846571804264 | -0.0779792544266095 | 9.34901534736507e-12 | 0.482259701101472 |
| IFG | 0.206362430639664 | 0.261691917984511 | 0.588386293708733 | 0.11370436544058 | 4.27006821558988e-05 | 0.724139043215816 |
| PG | 0.0261066011868791 | -0.163122749981204 | 5.18546809430353e-06 | -0.327112002982523 | 7.34016541422539e-05 | 0.286538404379609 |
| STG | 0.609160724507639 | -0.0565874975366611 | 0.126346693683721 | -0.168120869967944 | 2.11830905226421e-07 | 0.530349070084345 |
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Relation with AD stages for SLC38A3 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 1.38330913854436e-06 | 0.448988496190599 |
| IFG | 0.0320112739229262 | 0.429790327906529 |
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RelatedDrugs for SLC38A3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC38A3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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