ADeditome: functional annotation of RNA A-to-I editing in AD

Gene summary for PNPLA6

Gene summary

Gene information	Gene symbol	PNPLA6
	Gene ID	10908
	Gene name	patatin like phospholipase domain containing 6
	Synonyms	BNHS\|LNMS\|NTE\|NTEMND\|OMCS\|SPG39\|iPLA2delta\|sws
	Cytomap	19p13.2
	Type of gene	protein-coding
	Description	neuropathy target esterasepatatin-like phospholipase domain-containing protein 6
	Modification date	20200313
	UniProtAcc	Q8IY17,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for PNPLA6

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_793391(7536771, +), ADediting_793392(7536807, +), ADediting_793393(7536882, +), ADediting_793394(7537690, +), ADediting_793395(7537703, +), ADediting_793396(7537706, +), ADediting_793397(7537744, +), ADediting_793398(7537781, +), ADediting_793399(7537902, +), ADediting_793400(7537920, +), ADediting_793401(7538228, +), ADediting_793402(7538244, +), ADediting_793403(7538249, +), ADediting_793404(7538280, +), ADediting_793405(7538298, +), ADediting_793406(7538315, +), ADediting_793407(7538397, +), ADediting_793408(7538418, +), ADediting_793409(7538421, +), ADediting_793410(7538422, +), ADediting_793411(7538445, +), ADediting_793412(7539258, +), ADediting_793413(7539313, +), ADediting_793414(7539358, +), ADediting_793415(7539364, +), ADediting_793416(7539497, +), ADediting_793417(7539626, +), ADediting_793418(7539646, +), ADediting_793419(7539649, +), ADediting_793420(7544332, +), ADediting_793421(7544373, +), ADediting_793422(7544374, +), ADediting_793423(7544386, +), ADediting_793424(7544392, +), ADediting_793425(7545082, +), ADediting_793426(7545107, +), ADediting_793427(7545126, +), ADediting_793428(7545127, +), ADediting_793429(7545139, +), ADediting_793430(7545144, +), ADediting_793431(7545166, +), ADediting_793432(7545172, +), ADediting_793433(7545182, +), ADediting_793434(7545224, +), ADediting_793435(7545236, +), ADediting_793436(7545247, +), ADediting_793437(7545248, +), ADediting_793438(7545249, +), ADediting_793439(7545261, +), ADediting_793440(7545262, +), ADediting_793441(7545266, +), ADediting_793442(7545279, +), ADediting_793443(7545288, +), ADediting_793444(7545638, +), ADediting_793445(7545648, +), ADediting_793446(7545656, +), ADediting_793447(7545657, +), ADediting_793448(7545665, +), ADediting_793449(7545679, +), ADediting_793450(7545684, +), ADediting_793451(7545686, +), ADediting_793452(7545692, +), ADediting_793453(7545711, +), ADediting_793454(7545713, +), ADediting_793455(7545725, +), ADediting_793456(7545726, +), ADediting_793457(7545747, +), ADediting_793458(7545765, +), ADediting_793459(7545769, +), ADediting_793460(7545773, +), ADediting_793461(7545814, +), ADediting_793462(7545818, +), ADediting_793463(7545827, +), ADediting_793464(7545833, +), ADediting_793465(7545837, +), ADediting_793466(7545855, +), ADediting_793467(7545867, +), ADediting_793468(7545875, +), ADediting_793469(7545890, +), ADediting_793470(7546355, +), ADediting_793471(7546357, +), ADediting_793472(7546365, +), ADediting_793473(7546373, +), ADediting_793474(7546374, +), ADediting_793475(7546382, +), ADediting_793476(7546390, +), ADediting_793477(7546419, +), ADediting_793478(7546450, +), ADediting_793479(7546451, +), ADediting_793480(7546487, +), ADediting_793481(7546491, +), ADediting_793482(7546505, +), ADediting_793483(7546513, +), ADediting_793484(7546519, +), ADediting_793485(7546536, +), ADediting_793486(7546683, +), ADediting_793487(7546974, +), ADediting_793488(7547022, +), ADediting_793489(7547050, +), ADediting_793490(7547102, +), ADediting_793491(7547157, +), ADediting_793492(7547166, +), ADediting_793493(7547167, +), ADediting_793494(7547179, +), ADediting_793495(7547195, +), ADediting_793496(7547516, +), ADediting_793497(7547531, +), ADediting_793498(7547603, +), ADediting_793499(7547604, +), ADediting_793500(7547605, +), ADediting_793501(7547738, +), ADediting_793502(7547741, +), ADediting_793503(7547755, +), ADediting_793504(7547771, +), ADediting_793505(7547925, +), ADediting_793506(7547937, +), ADediting_793507(7548072, +), ADediting_793508(7548074, +), ADediting_793509(7548084, +), ADediting_793510(7548090, +), ADediting_793511(7548091, +), ADediting_793512(7548096, +), ADediting_793513(7548126, +), ADediting_793514(7548144, +), ADediting_793515(7548158, +), ADediting_793516(7548168, +), ADediting_793517(7548224, +), ADediting_793518(7548276, +), ADediting_793519(7548326, +), ADediting_793520(7548331, +), ADediting_793521(7548932, +), ADediting_793522(7549009, +), ADediting_793523(7549065, +), ADediting_793524(7549077, +), ADediting_793525(7549344, +), ADediting_793526(7549393, +), ADediting_793527(7549448, +), ADediting_793528(7549460, +), ADediting_793529(7549545, +), ADediting_793530(7549582, +), ADediting_793531(7549592, +), ADediting_793532(7549606, +), ADediting_793533(7549650, +), ADediting_793534(7549749, +), ADediting_793535(7551844, +), ADediting_793536(7551845, +), ADediting_793537(7551867, +), ADediting_793538(7551890, +), ADediting_793539(7551924, +), ADediting_793540(7551986, +), ADediting_793541(7552000, +), ADediting_793542(7552570, +), ADediting_793543(7552590, +), ADediting_793544(7552593, +), ADediting_793545(7552594, +), ADediting_793546(7552595, +), ADediting_793547(7552596, +), ADediting_793548(7552608, +), ADediting_793549(7552634, +), ADediting_793550(7552644, +), ADediting_793551(7552657, +), ADediting_793552(7552661, +), ADediting_793553(7552666, +), ADediting_793554(7552667, +), ADediting_793555(7552675, +), ADediting_793556(7552676, +), ADediting_793557(7552743, +), ADediting_793558(7552744, +), ADediting_793559(7552745, +), ADediting_793560(7552751, +), ADediting_793561(7552761, +), ADediting_793562(7552776, +), ADediting_793563(7552777, +), ADediting_793564(7552779, +), ADediting_793565(7553270, +), ADediting_793566(7553271, +), ADediting_793567(7553275, +), ADediting_793568(7553352, +), ADediting_793569(7553369, +), ADediting_793570(7553377, +), ADediting_793571(7553381, +), ADediting_793572(7553391, +), ADediting_793573(7553417, +), ADediting_793574(7553418, +), ADediting_793575(7553434, +), ADediting_793576(7553437, +), ADediting_1559936(7546806, +), ADediting_1559937(7547676, +), ADediting_1559938(7553404, +),

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RNA editing positional annotations for PNPLA6 using Annovar

Protein coding RNA editing(s).

ADeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_793391	chr19_7536771_+	intronic
ADediting_793392	chr19_7536807_+	intronic
ADediting_793393	chr19_7536882_+	intronic
ADediting_793394	chr19_7537690_+	intronic
ADediting_793395	chr19_7537703_+	intronic
ADediting_793396	chr19_7537706_+	intronic
ADediting_793397	chr19_7537744_+	intronic
ADediting_793398	chr19_7537781_+	intronic
ADediting_793399	chr19_7537902_+	intronic
ADediting_793400	chr19_7537920_+	intronic
ADediting_793401	chr19_7538228_+	intronic
ADediting_793402	chr19_7538244_+	intronic
ADediting_793403	chr19_7538249_+	intronic
ADediting_793404	chr19_7538280_+	intronic
ADediting_793405	chr19_7538298_+	intronic
ADediting_793406	chr19_7538315_+	intronic
ADediting_793407	chr19_7538397_+	intronic
ADediting_793408	chr19_7538418_+	intronic
ADediting_793409	chr19_7538421_+	intronic
ADediting_793410	chr19_7538422_+	intronic
ADediting_793411	chr19_7538445_+	intronic
ADediting_793412	chr19_7539258_+	intronic
ADediting_793413	chr19_7539313_+	intronic
ADediting_793414	chr19_7539358_+	intronic
ADediting_793415	chr19_7539364_+	intronic
ADediting_793416	chr19_7539497_+	intronic
ADediting_793417	chr19_7539626_+	intronic
ADediting_793418	chr19_7539646_+	intronic
ADediting_793419	chr19_7539649_+	intronic
ADediting_793420	chr19_7544332_+	intronic
ADediting_793421	chr19_7544373_+	intronic
ADediting_793422	chr19_7544374_+	intronic
ADediting_793423	chr19_7544386_+	intronic
ADediting_793424	chr19_7544392_+	intronic
ADediting_793425	chr19_7545082_+	intronic
ADediting_793426	chr19_7545107_+	intronic
ADediting_793427	chr19_7545126_+	intronic
ADediting_793428	chr19_7545127_+	intronic
ADediting_793429	chr19_7545139_+	intronic
ADediting_793430	chr19_7545144_+	intronic
ADediting_793431	chr19_7545166_+	intronic
ADediting_793432	chr19_7545172_+	intronic
ADediting_793433	chr19_7545182_+	intronic
ADediting_793434	chr19_7545224_+	intronic
ADediting_793435	chr19_7545236_+	intronic
ADediting_793436	chr19_7545247_+	intronic
ADediting_793437	chr19_7545248_+	intronic
ADediting_793438	chr19_7545249_+	intronic
ADediting_793439	chr19_7545261_+	intronic
ADediting_793440	chr19_7545262_+	intronic
ADediting_793441	chr19_7545266_+	intronic
ADediting_793442	chr19_7545279_+	intronic
ADediting_793443	chr19_7545288_+	intronic
ADediting_793444	chr19_7545638_+	intronic
ADediting_793445	chr19_7545648_+	intronic
ADediting_793446	chr19_7545656_+	intronic
ADediting_793447	chr19_7545657_+	intronic
ADediting_793448	chr19_7545665_+	intronic
ADediting_793449	chr19_7545679_+	intronic
ADediting_793450	chr19_7545684_+	intronic
ADediting_793451	chr19_7545686_+	intronic
ADediting_793452	chr19_7545692_+	intronic
ADediting_793453	chr19_7545711_+	intronic
ADediting_793454	chr19_7545713_+	intronic
ADediting_793455	chr19_7545725_+	intronic
ADediting_793456	chr19_7545726_+	intronic
ADediting_793457	chr19_7545747_+	intronic
ADediting_793458	chr19_7545765_+	intronic
ADediting_793459	chr19_7545769_+	intronic
ADediting_793460	chr19_7545773_+	intronic
ADediting_793461	chr19_7545814_+	intronic
ADediting_793462	chr19_7545818_+	intronic
ADediting_793463	chr19_7545827_+	intronic
ADediting_793464	chr19_7545833_+	intronic
ADediting_793465	chr19_7545837_+	intronic
ADediting_793466	chr19_7545855_+	intronic
ADediting_793467	chr19_7545867_+	intronic
ADediting_793468	chr19_7545875_+	intronic
ADediting_793469	chr19_7545890_+	intronic
ADediting_793470	chr19_7546355_+	intronic
ADediting_793471	chr19_7546357_+	intronic
ADediting_793472	chr19_7546365_+	intronic
ADediting_793473	chr19_7546373_+	intronic
ADediting_793474	chr19_7546374_+	intronic
ADediting_793475	chr19_7546382_+	intronic
ADediting_793476	chr19_7546390_+	intronic
ADediting_793477	chr19_7546419_+	intronic
ADediting_793478	chr19_7546450_+	intronic
ADediting_793479	chr19_7546451_+	intronic
ADediting_793480	chr19_7546487_+	intronic
ADediting_793481	chr19_7546491_+	intronic
ADediting_793482	chr19_7546505_+	intronic
ADediting_793483	chr19_7546513_+	intronic
ADediting_793484	chr19_7546519_+	intronic
ADediting_793485	chr19_7546536_+	intronic
ADediting_793486	chr19_7546683_+	intronic
ADediting_793487	chr19_7546974_+	intronic
ADediting_793488	chr19_7547022_+	intronic
ADediting_793489	chr19_7547050_+	intronic
ADediting_793490	chr19_7547102_+	intronic
ADediting_793491	chr19_7547157_+	intronic
ADediting_793492	chr19_7547166_+	intronic
ADediting_793493	chr19_7547167_+	intronic
ADediting_793494	chr19_7547179_+	intronic
ADediting_793495	chr19_7547195_+	intronic
ADediting_793496	chr19_7547516_+	intronic
ADediting_793497	chr19_7547531_+	intronic
ADediting_793498	chr19_7547603_+	intronic
ADediting_793499	chr19_7547604_+	intronic
ADediting_793500	chr19_7547605_+	intronic
ADediting_793501	chr19_7547738_+	intronic
ADediting_793502	chr19_7547741_+	intronic
ADediting_793503	chr19_7547755_+	intronic
ADediting_793504	chr19_7547771_+	intronic
ADediting_793505	chr19_7547925_+	intronic
ADediting_793506	chr19_7547937_+	intronic
ADediting_793507	chr19_7548072_+	intronic
ADediting_793508	chr19_7548074_+	intronic
ADediting_793509	chr19_7548084_+	intronic
ADediting_793510	chr19_7548090_+	intronic
ADediting_793511	chr19_7548091_+	intronic
ADediting_793512	chr19_7548096_+	intronic
ADediting_793513	chr19_7548126_+	intronic
ADediting_793514	chr19_7548144_+	intronic
ADediting_793515	chr19_7548158_+	intronic
ADediting_793516	chr19_7548168_+	intronic
ADediting_793517	chr19_7548224_+	intronic
ADediting_793518	chr19_7548276_+	intronic
ADediting_793519	chr19_7548326_+	intronic
ADediting_793520	chr19_7548331_+	intronic
ADediting_793521	chr19_7548932_+	intronic
ADediting_793522	chr19_7549009_+	intronic
ADediting_793523	chr19_7549065_+	intronic
ADediting_793524	chr19_7549077_+	intronic
ADediting_793525	chr19_7549344_+	intronic
ADediting_793526	chr19_7549393_+	intronic
ADediting_793527	chr19_7549448_+	intronic
ADediting_793528	chr19_7549460_+	intronic
ADediting_793529	chr19_7549545_+	intronic
ADediting_793530	chr19_7549582_+	intronic
ADediting_793531	chr19_7549592_+	intronic
ADediting_793532	chr19_7549606_+	intronic
ADediting_793533	chr19_7549650_+	intronic
ADediting_793534	chr19_7549749_+	intronic
ADediting_793535	chr19_7551844_+	intronic
ADediting_793536	chr19_7551845_+	intronic
ADediting_793537	chr19_7551867_+	intronic
ADediting_793538	chr19_7551890_+	intronic
ADediting_793539	chr19_7551924_+	intronic
ADediting_793540	chr19_7551986_+	intronic
ADediting_793541	chr19_7552000_+	intronic
ADediting_793542	chr19_7552570_+	intronic
ADediting_793543	chr19_7552590_+	intronic
ADediting_793544	chr19_7552593_+	intronic
ADediting_793545	chr19_7552594_+	intronic
ADediting_793546	chr19_7552595_+	intronic
ADediting_793547	chr19_7552596_+	intronic
ADediting_793548	chr19_7552608_+	intronic
ADediting_793549	chr19_7552634_+	intronic
ADediting_793550	chr19_7552644_+	intronic
ADediting_793551	chr19_7552657_+	intronic
ADediting_793552	chr19_7552661_+	intronic
ADediting_793553	chr19_7552666_+	intronic
ADediting_793554	chr19_7552667_+	intronic
ADediting_793555	chr19_7552675_+	intronic
ADediting_793556	chr19_7552676_+	intronic
ADediting_793557	chr19_7552743_+	intronic
ADediting_793558	chr19_7552744_+	intronic
ADediting_793559	chr19_7552745_+	intronic
ADediting_793560	chr19_7552751_+	intronic
ADediting_793561	chr19_7552761_+	intronic
ADediting_793562	chr19_7552776_+	intronic
ADediting_793563	chr19_7552777_+	intronic
ADediting_793564	chr19_7552779_+	intronic
ADediting_793565	chr19_7553270_+	intronic
ADediting_793566	chr19_7553271_+	intronic
ADediting_793567	chr19_7553275_+	intronic
ADediting_793568	chr19_7553352_+	intronic
ADediting_793569	chr19_7553369_+	intronic
ADediting_793570	chr19_7553377_+	intronic
ADediting_793571	chr19_7553381_+	intronic
ADediting_793572	chr19_7553391_+	intronic
ADediting_793573	chr19_7553417_+	intronic
ADediting_793574	chr19_7553418_+	intronic
ADediting_793575	chr19_7553434_+	intronic
ADediting_793576	chr19_7553437_+	intronic
ADediting_1559936	chr19_7546806_+	intronic
ADediting_1559937	chr19_7547676_+	intronic
ADediting_1559938	chr19_7553404_+	intronic

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_793391	chr19_7536771_+	SINE	Alu	Name=AluSx
ADediting_793392	chr19_7536807_+	SINE	Alu	Name=AluSx
ADediting_793393	chr19_7536882_+	SINE	Alu	Name=AluSx
ADediting_793394	chr19_7537690_+	SINE	Alu	Name=AluSc
ADediting_793395	chr19_7537703_+	SINE	Alu	Name=AluSc
ADediting_793396	chr19_7537706_+	SINE	Alu	Name=AluSc
ADediting_793397	chr19_7537744_+	SINE	Alu	Name=AluSc
ADediting_793398	chr19_7537781_+	SINE	Alu	Name=AluSc
ADediting_793399	chr19_7537902_+	SINE	Alu	Name=AluSc
ADediting_793400	chr19_7537920_+	SINE	Alu	Name=AluSc
ADediting_793401	chr19_7538228_+	SINE	Alu	Name=AluJr
ADediting_793402	chr19_7538244_+	SINE	Alu	Name=AluJr
ADediting_793403	chr19_7538249_+	SINE	Alu	Name=AluJr
ADediting_793404	chr19_7538280_+	SINE	Alu	Name=AluJr
ADediting_793405	chr19_7538298_+	SINE	Alu	Name=AluJr
ADediting_793406	chr19_7538315_+	SINE	Alu	Name=AluJr
ADediting_793407	chr19_7538397_+	SINE	Alu	Name=AluJr
ADediting_793408	chr19_7538418_+	SINE	Alu	Name=AluJr
ADediting_793409	chr19_7538421_+	SINE	Alu	Name=AluJr
ADediting_793410	chr19_7538422_+	SINE	Alu	Name=AluJr
ADediting_793411	chr19_7538445_+	SINE	Alu	Name=AluJr
ADediting_793412	chr19_7539258_+	SINE	Alu	Name=AluSx3
ADediting_793413	chr19_7539313_+	SINE	Alu	Name=AluSx3
ADediting_793414	chr19_7539358_+	SINE	Alu	Name=AluSx3
ADediting_793415	chr19_7539364_+	SINE	Alu	Name=AluSx3
ADediting_793416	chr19_7539497_+	SINE	Alu	Name=AluSp
ADediting_793417	chr19_7539626_+	SINE	Alu	Name=AluSp
ADediting_793418	chr19_7539646_+	SINE	Alu	Name=AluSp
ADediting_793419	chr19_7539649_+	SINE	Alu	Name=AluSp
ADediting_793420	chr19_7544332_+	SINE	Alu	Name=AluSx
ADediting_793421	chr19_7544373_+	SINE	Alu	Name=AluSx
ADediting_793422	chr19_7544374_+	SINE	Alu	Name=AluSx
ADediting_793423	chr19_7544386_+	SINE	Alu	Name=AluSx
ADediting_793424	chr19_7544392_+	SINE	Alu	Name=AluSx
ADediting_793425	chr19_7545082_+	SINE	Alu	Name=AluSz
ADediting_793426	chr19_7545107_+	SINE	Alu	Name=AluSz
ADediting_793427	chr19_7545126_+	SINE	Alu	Name=AluSz
ADediting_793428	chr19_7545127_+	SINE	Alu	Name=AluSz
ADediting_793429	chr19_7545139_+	SINE	Alu	Name=AluSz
ADediting_793430	chr19_7545144_+	SINE	Alu	Name=AluSz
ADediting_793431	chr19_7545166_+	SINE	Alu	Name=AluSz
ADediting_793432	chr19_7545172_+	SINE	Alu	Name=AluSz
ADediting_793433	chr19_7545182_+	SINE	Alu	Name=AluSz
ADediting_793434	chr19_7545224_+	SINE	Alu	Name=AluSz
ADediting_793435	chr19_7545236_+	SINE	Alu	Name=AluSz
ADediting_793436	chr19_7545247_+	SINE	Alu	Name=AluSz
ADediting_793437	chr19_7545248_+	SINE	Alu	Name=AluSz
ADediting_793438	chr19_7545249_+	SINE	Alu	Name=AluSz
ADediting_793439	chr19_7545261_+	SINE	Alu	Name=AluSz
ADediting_793440	chr19_7545262_+	SINE	Alu	Name=AluSz
ADediting_793441	chr19_7545266_+	SINE	Alu	Name=AluSz
ADediting_793442	chr19_7545279_+	SINE	Alu	Name=AluSz
ADediting_793443	chr19_7545288_+	SINE	Alu	Name=AluSz
ADediting_793444	chr19_7545638_+	SINE	Alu	Name=AluSx1
ADediting_793445	chr19_7545648_+	SINE	Alu	Name=AluSx1
ADediting_793446	chr19_7545656_+	SINE	Alu	Name=AluSx1
ADediting_793447	chr19_7545657_+	SINE	Alu	Name=AluSx1
ADediting_793448	chr19_7545665_+	SINE	Alu	Name=AluSx1
ADediting_793449	chr19_7545679_+	SINE	Alu	Name=AluSx1
ADediting_793450	chr19_7545684_+	SINE	Alu	Name=AluSx1
ADediting_793451	chr19_7545686_+	SINE	Alu	Name=AluSx1
ADediting_793452	chr19_7545692_+	SINE	Alu	Name=AluSx1
ADediting_793453	chr19_7545711_+	SINE	Alu	Name=AluSx1
ADediting_793454	chr19_7545713_+	SINE	Alu	Name=AluSx1
ADediting_793455	chr19_7545725_+	SINE	Alu	Name=AluSx1
ADediting_793456	chr19_7545726_+	SINE	Alu	Name=AluSx1
ADediting_793457	chr19_7545747_+	SINE	Alu	Name=AluSx1
ADediting_793458	chr19_7545765_+	SINE	Alu	Name=AluSx1
ADediting_793459	chr19_7545769_+	SINE	Alu	Name=AluSx1
ADediting_793460	chr19_7545773_+	SINE	Alu	Name=AluSx1
ADediting_793461	chr19_7545814_+	SINE	Alu	Name=AluSx1
ADediting_793462	chr19_7545818_+	SINE	Alu	Name=AluSx1
ADediting_793463	chr19_7545827_+	SINE	Alu	Name=AluSx1
ADediting_793464	chr19_7545833_+	SINE	Alu	Name=AluSx1
ADediting_793465	chr19_7545837_+	SINE	Alu	Name=AluSx1
ADediting_793466	chr19_7545855_+	SINE	Alu	Name=AluSx1
ADediting_793467	chr19_7545867_+	SINE	Alu	Name=AluSx1
ADediting_793468	chr19_7545875_+	SINE	Alu	Name=AluSx1
ADediting_793469	chr19_7545890_+	SINE	Alu	Name=AluSx1
ADediting_793470	chr19_7546355_+	SINE	Alu	Name=AluJb
ADediting_793471	chr19_7546357_+	SINE	Alu	Name=AluJb
ADediting_793472	chr19_7546365_+	SINE	Alu	Name=AluJb
ADediting_793473	chr19_7546373_+	SINE	Alu	Name=AluJb
ADediting_793474	chr19_7546374_+	SINE	Alu	Name=AluJb
ADediting_793475	chr19_7546382_+	SINE	Alu	Name=AluJb
ADediting_793476	chr19_7546390_+	SINE	Alu	Name=AluJb
ADediting_793477	chr19_7546419_+	SINE	Alu	Name=AluJb
ADediting_793478	chr19_7546450_+	SINE	Alu	Name=AluJb
ADediting_793479	chr19_7546451_+	SINE	Alu	Name=AluJb
ADediting_793480	chr19_7546487_+	SINE	Alu	Name=AluJb
ADediting_793481	chr19_7546491_+	SINE	Alu	Name=AluJb
ADediting_793482	chr19_7546505_+	SINE	Alu	Name=AluJb
ADediting_793483	chr19_7546513_+	SINE	Alu	Name=AluJb
ADediting_793484	chr19_7546519_+	SINE	Alu	Name=AluJb
ADediting_793485	chr19_7546536_+	SINE	Alu	Name=AluJb
ADediting_793486	chr19_7546683_+	SINE	Alu	Name=AluSx
ADediting_793487	chr19_7546974_+	SINE	Alu	Name=AluSz
ADediting_793488	chr19_7547022_+	SINE	Alu	Name=AluSz
ADediting_793489	chr19_7547050_+	SINE	Alu	Name=AluSz
ADediting_793490	chr19_7547102_+	SINE	Alu	Name=AluSz
ADediting_793491	chr19_7547157_+	SINE	Alu	Name=AluSz
ADediting_793492	chr19_7547166_+	SINE	Alu	Name=AluSz
ADediting_793493	chr19_7547167_+	SINE	Alu	Name=AluSz
ADediting_793494	chr19_7547179_+	SINE	Alu	Name=AluSz
ADediting_793495	chr19_7547195_+	SINE	Alu	Name=AluSz
ADediting_793496	chr19_7547516_+	SINE	Alu	Name=FLAM_C
ADediting_793497	chr19_7547531_+	SINE	Alu	Name=FLAM_C
ADediting_793498	chr19_7547603_+	SINE	Alu	Name=FLAM_C
ADediting_793499	chr19_7547604_+	SINE	Alu	Name=FLAM_C
ADediting_793500	chr19_7547605_+	SINE	Alu	Name=FLAM_C
ADediting_793501	chr19_7547738_+	SINE	Alu	Name=AluJr4
ADediting_793502	chr19_7547741_+	SINE	Alu	Name=AluJr4
ADediting_793503	chr19_7547755_+	SINE	Alu	Name=AluJr4
ADediting_793504	chr19_7547771_+	SINE	Alu	Name=AluJr4
ADediting_793505	chr19_7547925_+	SINE	Alu	Name=AluJr4
ADediting_793506	chr19_7547937_+	SINE	Alu	Name=AluJr4
ADediting_793507	chr19_7548072_+	SINE	Alu	Name=AluSx1
ADediting_793508	chr19_7548074_+	SINE	Alu	Name=AluSx1
ADediting_793509	chr19_7548084_+	SINE	Alu	Name=AluSx1
ADediting_793510	chr19_7548090_+	SINE	Alu	Name=AluSx1
ADediting_793511	chr19_7548091_+	SINE	Alu	Name=AluSx1
ADediting_793512	chr19_7548096_+	SINE	Alu	Name=AluSx1
ADediting_793513	chr19_7548126_+	SINE	Alu	Name=AluSx1
ADediting_793514	chr19_7548144_+	SINE	Alu	Name=AluSx1
ADediting_793515	chr19_7548158_+	SINE	Alu	Name=AluSx1
ADediting_793516	chr19_7548168_+	SINE	Alu	Name=AluSx1
ADediting_793517	chr19_7548224_+	SINE	Alu	Name=AluSx1
ADediting_793518	chr19_7548276_+	SINE	Alu	Name=AluSx1
ADediting_793519	chr19_7548326_+	SINE	Alu	Name=AluSx1
ADediting_793520	chr19_7548331_+	SINE	Alu	Name=AluSx1
ADediting_793521	chr19_7548932_+	SINE	Alu	Name=AluY
ADediting_793522	chr19_7549009_+	SINE	Alu	Name=AluY
ADediting_793523	chr19_7549065_+	SINE	Alu	Name=AluY
ADediting_793524	chr19_7549077_+	SINE	Alu	Name=AluY
ADediting_793525	chr19_7549344_+	SINE	Alu	Name=AluY
ADediting_793526	chr19_7549393_+	SINE	Alu	Name=AluY
ADediting_793527	chr19_7549448_+	SINE	Alu	Name=AluY
ADediting_793528	chr19_7549460_+	SINE	Alu	Name=AluY
ADediting_793529	chr19_7549545_+	SINE	Alu	Name=AluSz6
ADediting_793530	chr19_7549582_+	SINE	Alu	Name=AluSz6
ADediting_793531	chr19_7549592_+	SINE	Alu	Name=AluSz6
ADediting_793532	chr19_7549606_+	SINE	Alu	Name=AluSz6
ADediting_793533	chr19_7549650_+	SINE	Alu	Name=AluSz6
ADediting_793534	chr19_7549749_+	SINE	Alu	Name=AluSz6
ADediting_793535	chr19_7551844_+	SINE	Alu	Name=AluJb
ADediting_793536	chr19_7551845_+	SINE	Alu	Name=AluJb
ADediting_793537	chr19_7551867_+	SINE	Alu	Name=AluJb
ADediting_793538	chr19_7551890_+	SINE	Alu	Name=AluJb
ADediting_793539	chr19_7551924_+	SINE	Alu	Name=AluJb
ADediting_793540	chr19_7551986_+	SINE	Alu	Name=AluJb
ADediting_793541	chr19_7552000_+	SINE	Alu	Name=AluJb
ADediting_793542	chr19_7552570_+	SINE	Alu	Name=AluSq2
ADediting_793543	chr19_7552590_+	SINE	Alu	Name=AluSq2
ADediting_793544	chr19_7552593_+	SINE	Alu	Name=AluSq2
ADediting_793545	chr19_7552594_+	SINE	Alu	Name=AluSq2
ADediting_793546	chr19_7552595_+	SINE	Alu	Name=AluSq2
ADediting_793547	chr19_7552596_+	SINE	Alu	Name=AluSq2
ADediting_793548	chr19_7552608_+	SINE	Alu	Name=AluSq2
ADediting_793549	chr19_7552634_+	SINE	Alu	Name=AluSq2
ADediting_793550	chr19_7552644_+	SINE	Alu	Name=AluSq2
ADediting_793551	chr19_7552657_+	SINE	Alu	Name=AluSq2
ADediting_793552	chr19_7552661_+	SINE	Alu	Name=AluSq2
ADediting_793553	chr19_7552666_+	SINE	Alu	Name=AluSq2
ADediting_793554	chr19_7552667_+	SINE	Alu	Name=AluSq2
ADediting_793555	chr19_7552675_+	SINE	Alu	Name=AluSq2
ADediting_793556	chr19_7552676_+	SINE	Alu	Name=AluSq2
ADediting_793557	chr19_7552743_+	SINE	Alu	Name=AluSq2
ADediting_793558	chr19_7552744_+	SINE	Alu	Name=AluSq2
ADediting_793559	chr19_7552745_+	SINE	Alu	Name=AluSq2
ADediting_793560	chr19_7552751_+	SINE	Alu	Name=AluSq2
ADediting_793561	chr19_7552761_+	SINE	Alu	Name=AluSq2
ADediting_793562	chr19_7552776_+	SINE	Alu	Name=AluSq2
ADediting_793563	chr19_7552777_+	SINE	Alu	Name=AluSq2
ADediting_793564	chr19_7552779_+	SINE	Alu	Name=AluSq2
ADediting_793565	chr19_7553270_+	SINE	Alu	Name=AluSx3
ADediting_793566	chr19_7553271_+	SINE	Alu	Name=AluSx3
ADediting_793567	chr19_7553275_+	SINE	Alu	Name=AluSx3
ADediting_793568	chr19_7553352_+	SINE	Alu	Name=AluSx3
ADediting_793569	chr19_7553369_+	SINE	Alu	Name=AluSx3
ADediting_793570	chr19_7553377_+	SINE	Alu	Name=AluSx3
ADediting_793571	chr19_7553381_+	SINE	Alu	Name=AluSx3
ADediting_793572	chr19_7553391_+	SINE	Alu	Name=AluSx3
ADediting_793573	chr19_7553417_+	SINE	Alu	Name=AluSx3
ADediting_793574	chr19_7553418_+	SINE	Alu	Name=AluSx3
ADediting_793575	chr19_7553434_+	SINE	Alu	Name=AluSx3
ADediting_793576	chr19_7553437_+	SINE	Alu	Name=AluSx3
ADediting_1559936	chr19_7546806_+	SINE	Alu	Name=FLAM_C
ADediting_1559937	chr19_7547676_+	SINE	Alu	Name=AluJr4
ADediting_1559938	chr19_7553404_+	SINE	Alu	Name=AluSx3

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RNA A-to-I editing events in the alternative splicing sites for PNPLA6

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

ADeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PNPLA6

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

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Protein coding region RNA A-to-I editings for PNPLA6

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for PNPLA6

RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

ADediting_793534

chr19_7549749_+

ENSG00000032444.16

ENST00000594864.1

PNPLA6-209

hsa-miR-3189-3p

chr19

7549744

7549750

7mer-m8

7549728

7549751

145

-21.43

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PNPLA6

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000594864.1	lncRNA

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID

ENST

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in lncRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_793534	ENST00000594864.1	chr19_7549749_+	49	-249.70	-245.10	-249.70

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Relation with ADAR for PNPLA6

Correlation between ADAR gene expression and RNA editing frequency

Tissue	ADeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	ADediting_793394	chr19_7537690_+	0.750262079835852	0.0181497047522198	0.131599255920151	-0.0858273481451101	9.60046591944899e-12	0.374275290680997
CER	ADediting_793423	chr19_7544386_+	0.772195422042675	-0.0238339579202021	0.213997747689413	0.102050328724131	0.000119854173328889	0.308926162108815
DLPFC	ADediting_793424	chr19_7544392_+	0.736126665404321	-0.0192154364579379	0.117484658122984	-0.089092858472679	2.15666333983721e-10	0.350549633233369
DLPFC	ADediting_793431	chr19_7545166_+	0.68104485460742	0.0234368475054448	0.498421893416315	-0.0385911628683335	2.32561997087633e-09	0.330985527060881
DLPFC	ADediting_793455	chr19_7545725_+	0.650928120692321	-0.0257986936114858	0.0348483355741599	-0.119898262104564	5.77375669945005e-08	0.302145889854552
DLPFC	ADediting_793456	chr19_7545726_+	0.447141669367532	-0.0433305917124076	0.00837272390498463	-0.149513449993999	2.44442962154063e-09	0.330560610344857
DLPFC	ADediting_793491	chr19_7547157_+	0.00631214687496661	0.15480581264714	0.110408574445613	0.0908465457291341	6.23411486839266e-08	0.301417860357476
DLPFC	ADediting_793526	chr19_7549393_+	0.142454305885357	0.0834954453430198	0.986637487934508	0.000955092436305716	4.08684012076991e-12	0.380460772488854
DLPFC	ADediting_793540	chr19_7551986_+	0.0138445038162849	0.139669285595128	0.271452635161268	0.062651813281944	4.29258503671918e-09	0.325712663097563
CER	ADediting_793546	chr19_7552595_+	0.153334169640124	0.117161904259159	0.000100784805284806	0.312150922660731	0.114652327614461	0.129352664168584
CER	ADediting_793547	chr19_7552596_+	0.120850249306896	0.127205191043222	1.30722240547226e-05	0.347644995759379	0.154915409893817	0.116716054880077
CER	ADediting_793575	chr19_7553434_+	0.0539800619120932	0.157671993154303	0.000148607883171275	0.304872224897544	6.73773985077251e-05	0.319505081855375
CER	ADediting_793576	chr19_7553437_+	0.0337964509415816	0.173436030650035	7.0439258871124e-07	0.39194910310622	0.000600463557121745	0.276987750909207

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	5.04589385076774e-06	0.255860770201173	3.95544985507366e-10	0.345687336253247	4.1659279155344e-18	0.465879365279831
AC	5.43951299759632e-08	0.335487668798746	2.11291398384294e-08	0.345116013135353	2.5344403211592e-05	0.262986161213807
PCC	2.55369639890728e-09	0.414294640294844	4.90251157550223e-10	0.430883711727811	0.0188248645514692	0.169844434229149
CER	0.000460537329717502	0.282510433344344	5.34429341896517e-16	0.59938163752359	9.8922510047667e-08	0.418452990116632
TCX	0.00018855709931358	0.300313779898754	0.0347490852526317	0.172532904242005	3.5752592903117e-05	0.330706747025888
FP	3.57682632639391e-10	0.448064720381594	0.000244366702365054	0.271660401385974	2.74108032804766e-14	0.530136307047472
IFG	1.28113129167744e-05	0.75517244499086	8.95673382669071e-07	0.810664770216071	0.0587320776024299	0.383084203243759
PG	0.86051582534572	0.0129711382957379	0.725695789183411	0.0258963276465471	1.72742445057622e-07	0.371897960346241
STG	4.43732430270597e-08	0.554489557355444	0.00244383999128526	0.326407876531591	7.68478917898463e-05	0.417774938845669

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Relation with AD stages for PNPLA6

Correlation between AD stages and RNA editing frequency

Tissue	ADeditomID	position	P-val	Coeff.
CER	ADediting_793576	chr19_7553437_+	0.00112192671688968	0.309374550496066

Correlation between AD stages and this gene's expression

Tissue	P-val	Coeff.
CER	3.62383997423831e-08	0.499905868602663
TCX	0.000230302573454816	0.350484757459571

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RelatedDrugs for PNPLA6

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for PNPLA6

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
PNPLA6	C3714756	Intellectual Disability	5	GENOMICS_ENGLAND
PNPLA6	C0085084	Motor Neuron Disease	2	CTD_human
PNPLA6	C0154681	Anterior Horn Cell Disease	2	CTD_human
PNPLA6	C0154682	Lateral Sclerosis	2	CTD_human
PNPLA6	C0270763	Familial Motor Neuron Disease	2	CTD_human
PNPLA6	C0270764	Motor Neuron Disease, Lower	2	CTD_human
PNPLA6	C0521659	Motor Neuron Disease, Upper	2	CTD_human
PNPLA6	C0543858	Motor Neuron Disease, Secondary	2	CTD_human
PNPLA6	C1859093	Chorioretinal Dystrophy, Spinocerebellar Ataxia, and Hypogonadotropic Hypogonadism	2	CTD_human;ORPHANET;UNIPROT
PNPLA6	C2677586	Spastic Paraplegia 39, Autosomal Recessive	2	CTD_human;ORPHANET;UNIPROT
PNPLA6	C0023138	Laurence-Moon Syndrome	1	CTD_human;ORPHANET;UNIPROT
PNPLA6	C0027765	nervous system disorder	1	CTD_human
PNPLA6	C0031117	Peripheral Neuropathy	1	CTD_human
PNPLA6	C0037050	Sick Building Syndrome	1	CTD_human
PNPLA6	C0037773	Spastic Paraplegia, Hereditary	1	CTD_human;GENOMICS_ENGLAND
PNPLA6	C0152025	Polyneuropathy	1	CTD_human
PNPLA6	C0271683	Polyneuropathy, Motor	1	CTD_human
PNPLA6	C0393851	Polyneuropathy, Critical Illness	1	CTD_human
PNPLA6	C0751448	Polyneuropathy, Familial	1	CTD_human
PNPLA6	C0751449	Acquired Polyneuropathy	1	CTD_human
PNPLA6	C0751602	Hereditary Autosomal Dominant Spastic Paraplegia	1	CTD_human
PNPLA6	C0751603	Autosomal Recessive Hereditary Spastic Paraplegia	1	CTD_human
PNPLA6	C0751604	Hereditary X-Linked Recessive Spastic Paraplegia	1	CTD_human
PNPLA6	C0751605	X-Linked, Spastic Paraplegia, Hereditary	1	CTD_human
PNPLA6	C1848745	Oliver-McFarlane syndrome	1	CTD_human;ORPHANET;UNIPROT

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Gene summary for PNPLA6

RNA A-to-I events for PNPLA6

RNA editing positional annotations for PNPLA6 using Annovar

RNA A-to-I editing events in the alternative splicing sites for PNPLA6

Differntial gene expression between RNA A-to-I edited versus non-edited samples for PNPLA6

Protein coding region RNA A-to-I editings for PNPLA6

The effects of the RNA editing to the miRNA binding sites for PNPLA6

The effects of the RNA editing to the stability of the RNA structures for PNPLA6

Relation with ADAR for PNPLA6

Relation with AD stages for PNPLA6

RelatedDrugs for PNPLA6

RelatedDiseases for PNPLA6

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene