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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for TXNL4A |
 Gene summary |
| Gene information | Gene symbol | TXNL4A | Gene ID | 10907 |
| Gene name | thioredoxin like 4A | |
| Synonyms | BMKS|DIB1|DIM1|SNRNP15|TXNL4|U5-15kD | |
| Cytomap | 18q23 | |
| Type of gene | protein-coding | |
| Description | thioredoxin-like protein 4ADIM1 protein homologspliceosomal U5 snRNP-specific 15 kDa proteinthioredoxin-like 4thioredoxin-like U5 snRNP protein U5-15kD | |
| Modification date | 20200313 | |
| UniProtAcc | P83876, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TXNL4A | GO:0000398 | mRNA splicing, via spliceosome | 28781166 |
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RNA A-to-I events for TXNL4A |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_699097(79971396, -), ADediting_699098(79971400, -), ADediting_699099(79971401, -), ADediting_699100(79971411, -), ADediting_699101(79971419, -), ADediting_699102(79971425, -), ADediting_699103(79972668, -), ADediting_699104(79972736, -), ADediting_699105(79972742, -), ADediting_699106(79972754, -), ADediting_699107(79972758, -), ADediting_699108(79974156, -), ADediting_699109(79974168, -), ADediting_699110(79974178, -), ADediting_699111(79974195, -), ADediting_699112(79974196, -), ADediting_699113(79974540, -), ADediting_699114(79974603, -), ADediting_699115(79974746, -), ADediting_699116(79974751, -), ADediting_699117(79974752, -), ADediting_699118(79974770, -), ADediting_699119(79976990, -), ADediting_699120(79977003, -), ADediting_699121(79977072, -), ADediting_699122(79977907, -), ADediting_699123(79977944, -), ADediting_699124(79981437, -), ADediting_699125(79981454, -), ADediting_699126(79981509, -), ADediting_699127(79981528, -), ADediting_699128(79981564, -), ADediting_699129(79981572, -), ADediting_699130(79983138, -), ADediting_699131(79983139, -), ADediting_699132(79983161, -), ADediting_699133(79983165, -), ADediting_699134(79983170, -), ADediting_699135(79983171, -), ADediting_699136(79983174, -), ADediting_699137(79983176, -), ADediting_699138(79983177, -), ADediting_699139(79983179, -), ADediting_699140(79983194, -), ADediting_699141(79983202, -), ADediting_699142(79983227, -), ADediting_699143(79983233, -), ADediting_699144(79983247, -), ADediting_699145(79983256, -), ADediting_699146(79983273, -), ADediting_699147(79983274, -), ADediting_699148(79983280, -), ADediting_699149(79983281, -), ADediting_699150(79984334, -), ADediting_699151(79984337, -), ADediting_699152(79984359, -), ADediting_699153(79984376, -), ADediting_699154(79984377, -), ADediting_699155(79984390, -), ADediting_699156(79984391, -), ADediting_699157(79984408, -), ADediting_699158(79984410, -), ADediting_699159(79984474, -), ADediting_699160(79984496, -), ADediting_699161(79984501, -), ADediting_699162(79984533, -), ADediting_699163(79984689, -), ADediting_699164(79984746, -), ADediting_699165(79984747, -), ADediting_699166(79984760, -), ADediting_699167(79985381, -), ADediting_699168(79985384, -), ADediting_699169(79985413, -), ADediting_699170(79985428, -), ADediting_699171(79985430, -), ADediting_699172(79985432, -), ADediting_699173(79985454, -), ADediting_699174(79986178, -), ADediting_699175(79986237, -), ADediting_699176(79986321, -), ADediting_699177(80008092, -), ADediting_699178(80008915, -), ADediting_699179(80008916, -), ADediting_699180(80008951, -), ADediting_699181(80019414, -), ADediting_699182(80019417, -), ADediting_699183(80019423, -), ADediting_699184(80019432, -), ADediting_699185(80019442, -), ADediting_699186(80020010, -), ADediting_699187(80020039, -), ADediting_699188(80020062, -), ADediting_699189(80020063, -), ADediting_699190(80020074, -), ADediting_699191(80030801, -), ADediting_699192(80030843, -), ADediting_699193(80030855, -), ADediting_699194(80032647, -), ADediting_1551224(79977901, -), ADediting_1551225(79983098, -), ADediting_1551226(79983183, -), ADediting_1551227(79983189, -), ADediting_1551228(79983204, -), ADediting_1551229(79984427, -), ADediting_1551230(79984445, -), ADediting_1551231(79985303, -), ADediting_1551232(79985446, -), ADediting_1551233(79985468, -), |
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RNA editing positional annotations for TXNL4A using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_699097 | chr18_79971396_- | UTR3 |
| ADediting_699098 | chr18_79971400_- | UTR3 |
| ADediting_699099 | chr18_79971401_- | UTR3 |
| ADediting_699100 | chr18_79971411_- | UTR3 |
| ADediting_699101 | chr18_79971419_- | UTR3 |
| ADediting_699102 | chr18_79971425_- | UTR3 |
| ADediting_699103 | chr18_79972668_- | UTR3 |
| ADediting_699104 | chr18_79972736_- | UTR3 |
| ADediting_699105 | chr18_79972742_- | UTR3 |
| ADediting_699106 | chr18_79972754_- | UTR3 |
| ADediting_699107 | chr18_79972758_- | UTR3 |
| ADediting_699108 | chr18_79974156_- | intronic |
| ADediting_699109 | chr18_79974168_- | intronic |
| ADediting_699110 | chr18_79974178_- | intronic |
| ADediting_699111 | chr18_79974195_- | intronic |
| ADediting_699112 | chr18_79974196_- | intronic |
| ADediting_699113 | chr18_79974540_- | intronic |
| ADediting_699114 | chr18_79974603_- | intronic |
| ADediting_699115 | chr18_79974746_- | intronic |
| ADediting_699116 | chr18_79974751_- | intronic |
| ADediting_699117 | chr18_79974752_- | intronic |
| ADediting_699118 | chr18_79974770_- | intronic |
| ADediting_699119 | chr18_79976990_- | intronic |
| ADediting_699120 | chr18_79977003_- | intronic |
| ADediting_699121 | chr18_79977072_- | intronic |
| ADediting_699122 | chr18_79977907_- | UTR5 |
| ADediting_699123 | chr18_79977944_- | intronic |
| ADediting_699124 | chr18_79981437_- | intronic |
| ADediting_699125 | chr18_79981454_- | intronic |
| ADediting_699126 | chr18_79981509_- | intronic |
| ADediting_699127 | chr18_79981528_- | intronic |
| ADediting_699128 | chr18_79981564_- | intronic |
| ADediting_699129 | chr18_79981572_- | intronic |
| ADediting_699130 | chr18_79983138_- | intronic |
| ADediting_699131 | chr18_79983139_- | intronic |
| ADediting_699132 | chr18_79983161_- | intronic |
| ADediting_699133 | chr18_79983165_- | intronic |
| ADediting_699134 | chr18_79983170_- | intronic |
| ADediting_699135 | chr18_79983171_- | intronic |
| ADediting_699136 | chr18_79983174_- | intronic |
| ADediting_699137 | chr18_79983176_- | intronic |
| ADediting_699138 | chr18_79983177_- | intronic |
| ADediting_699139 | chr18_79983179_- | intronic |
| ADediting_699140 | chr18_79983194_- | intronic |
| ADediting_699141 | chr18_79983202_- | intronic |
| ADediting_699142 | chr18_79983227_- | intronic |
| ADediting_699143 | chr18_79983233_- | intronic |
| ADediting_699144 | chr18_79983247_- | intronic |
| ADediting_699145 | chr18_79983256_- | intronic |
| ADediting_699146 | chr18_79983273_- | intronic |
| ADediting_699147 | chr18_79983274_- | intronic |
| ADediting_699148 | chr18_79983280_- | intronic |
| ADediting_699149 | chr18_79983281_- | intronic |
| ADediting_699150 | chr18_79984334_- | intronic |
| ADediting_699151 | chr18_79984337_- | intronic |
| ADediting_699152 | chr18_79984359_- | intronic |
| ADediting_699153 | chr18_79984376_- | intronic |
| ADediting_699154 | chr18_79984377_- | intronic |
| ADediting_699155 | chr18_79984390_- | intronic |
| ADediting_699156 | chr18_79984391_- | intronic |
| ADediting_699157 | chr18_79984408_- | intronic |
| ADediting_699158 | chr18_79984410_- | intronic |
| ADediting_699159 | chr18_79984474_- | intronic |
| ADediting_699160 | chr18_79984496_- | intronic |
| ADediting_699161 | chr18_79984501_- | intronic |
| ADediting_699162 | chr18_79984533_- | intronic |
| ADediting_699163 | chr18_79984689_- | intronic |
| ADediting_699164 | chr18_79984746_- | intronic |
| ADediting_699165 | chr18_79984747_- | intronic |
| ADediting_699166 | chr18_79984760_- | intronic |
| ADediting_699167 | chr18_79985381_- | intronic |
| ADediting_699168 | chr18_79985384_- | intronic |
| ADediting_699169 | chr18_79985413_- | intronic |
| ADediting_699170 | chr18_79985428_- | intronic |
| ADediting_699171 | chr18_79985430_- | intronic |
| ADediting_699172 | chr18_79985432_- | intronic |
| ADediting_699173 | chr18_79985454_- | intronic |
| ADediting_699174 | chr18_79986178_- | intronic |
| ADediting_699175 | chr18_79986237_- | intronic |
| ADediting_699176 | chr18_79986321_- | intronic |
| ADediting_699177 | chr18_80008092_- | intronic |
| ADediting_699178 | chr18_80008915_- | intronic |
| ADediting_699179 | chr18_80008916_- | intronic |
| ADediting_699180 | chr18_80008951_- | intronic |
| ADediting_699181 | chr18_80019414_- | intronic |
| ADediting_699182 | chr18_80019417_- | intronic |
| ADediting_699183 | chr18_80019423_- | intronic |
| ADediting_699184 | chr18_80019432_- | intronic |
| ADediting_699185 | chr18_80019442_- | intronic |
| ADediting_699186 | chr18_80020010_- | intronic |
| ADediting_699187 | chr18_80020039_- | intronic |
| ADediting_699188 | chr18_80020062_- | intronic |
| ADediting_699189 | chr18_80020063_- | intronic |
| ADediting_699190 | chr18_80020074_- | intronic |
| ADediting_699191 | chr18_80030801_- | intronic |
| ADediting_699192 | chr18_80030843_- | intronic |
| ADediting_699193 | chr18_80030855_- | intronic |
| ADediting_699194 | chr18_80032647_- | intronic |
| ADediting_1551224 | chr18_79977901_- | UTR5 |
| ADediting_1551225 | chr18_79983098_- | intronic |
| ADediting_1551226 | chr18_79983183_- | intronic |
| ADediting_1551227 | chr18_79983189_- | intronic |
| ADediting_1551228 | chr18_79983204_- | intronic |
| ADediting_1551229 | chr18_79984427_- | intronic |
| ADediting_1551230 | chr18_79984445_- | intronic |
| ADediting_1551231 | chr18_79985303_- | intronic |
| ADediting_1551232 | chr18_79985446_- | intronic |
| ADediting_1551233 | chr18_79985468_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_699097 | chr18_79971396_- | SINE | Alu | Name=AluJb |
| ADediting_699098 | chr18_79971400_- | SINE | Alu | Name=AluJb |
| ADediting_699099 | chr18_79971401_- | SINE | Alu | Name=AluJb |
| ADediting_699100 | chr18_79971411_- | SINE | Alu | Name=AluJb |
| ADediting_699101 | chr18_79971419_- | SINE | Alu | Name=AluJb |
| ADediting_699102 | chr18_79971425_- | SINE | Alu | Name=AluJb |
| ADediting_699103 | chr18_79972668_- | SINE | Alu | Name=AluSg |
| ADediting_699104 | chr18_79972736_- | SINE | Alu | Name=AluSg |
| ADediting_699105 | chr18_79972742_- | SINE | Alu | Name=AluSg |
| ADediting_699106 | chr18_79972754_- | SINE | Alu | Name=AluSg |
| ADediting_699107 | chr18_79972758_- | SINE | Alu | Name=AluSg |
| ADediting_699108 | chr18_79974156_- | SINE | Alu | Name=FLAM_C |
| ADediting_699109 | chr18_79974168_- | SINE | Alu | Name=FLAM_C |
| ADediting_699110 | chr18_79974178_- | SINE | Alu | Name=FLAM_C |
| ADediting_699111 | chr18_79974195_- | SINE | Alu | Name=FLAM_C |
| ADediting_699112 | chr18_79974196_- | SINE | Alu | Name=FLAM_C |
| ADediting_699113 | chr18_79974540_- | SINE | Alu | Name=AluYe5 |
| ADediting_699114 | chr18_79974603_- | SINE | Alu | Name=AluJb |
| ADediting_699115 | chr18_79974746_- | SINE | Alu | Name=AluJb |
| ADediting_699116 | chr18_79974751_- | SINE | Alu | Name=AluJb |
| ADediting_699117 | chr18_79974752_- | SINE | Alu | Name=AluJb |
| ADediting_699118 | chr18_79974770_- | SINE | Alu | Name=AluJb |
| ADediting_699119 | chr18_79976990_- | SINE | Alu | Name=AluSq2 |
| ADediting_699120 | chr18_79977003_- | SINE | Alu | Name=AluSq2 |
| ADediting_699121 | chr18_79977072_- | SINE | Alu | Name=AluSq2 |
| ADediting_699122 | chr18_79977907_- | SINE | Alu | Name=AluJb |
| ADediting_699123 | chr18_79977944_- | SINE | Alu | Name=AluJb |
| ADediting_699124 | chr18_79981437_- | SINE | Alu | Name=AluSz |
| ADediting_699125 | chr18_79981454_- | SINE | Alu | Name=AluSz |
| ADediting_699126 | chr18_79981509_- | SINE | Alu | Name=AluSz |
| ADediting_699127 | chr18_79981528_- | SINE | Alu | Name=AluSz |
| ADediting_699128 | chr18_79981564_- | SINE | Alu | Name=AluSz |
| ADediting_699129 | chr18_79981572_- | SINE | Alu | Name=AluSz |
| ADediting_699130 | chr18_79983138_- | SINE | Alu | Name=AluSx1 |
| ADediting_699131 | chr18_79983139_- | SINE | Alu | Name=AluSx1 |
| ADediting_699132 | chr18_79983161_- | SINE | Alu | Name=AluSx1 |
| ADediting_699133 | chr18_79983165_- | SINE | Alu | Name=AluSx1 |
| ADediting_699134 | chr18_79983170_- | SINE | Alu | Name=AluSx1 |
| ADediting_699135 | chr18_79983171_- | SINE | Alu | Name=AluSx1 |
| ADediting_699136 | chr18_79983174_- | SINE | Alu | Name=AluSx1 |
| ADediting_699137 | chr18_79983176_- | SINE | Alu | Name=AluSx1 |
| ADediting_699138 | chr18_79983177_- | SINE | Alu | Name=AluSx1 |
| ADediting_699139 | chr18_79983179_- | SINE | Alu | Name=AluSx1 |
| ADediting_699140 | chr18_79983194_- | SINE | Alu | Name=AluSx1 |
| ADediting_699141 | chr18_79983202_- | SINE | Alu | Name=AluSx1 |
| ADediting_699142 | chr18_79983227_- | SINE | Alu | Name=AluSx1 |
| ADediting_699143 | chr18_79983233_- | SINE | Alu | Name=AluSx1 |
| ADediting_699144 | chr18_79983247_- | SINE | Alu | Name=AluSx1 |
| ADediting_699145 | chr18_79983256_- | SINE | Alu | Name=AluSx1 |
| ADediting_699146 | chr18_79983273_- | SINE | Alu | Name=AluSx1 |
| ADediting_699147 | chr18_79983274_- | SINE | Alu | Name=AluSx1 |
| ADediting_699148 | chr18_79983280_- | SINE | Alu | Name=AluSx1 |
| ADediting_699149 | chr18_79983281_- | SINE | Alu | Name=AluSx1 |
| ADediting_699150 | chr18_79984334_- | SINE | Alu | Name=AluSz6 |
| ADediting_699151 | chr18_79984337_- | SINE | Alu | Name=AluSz6 |
| ADediting_699152 | chr18_79984359_- | SINE | Alu | Name=AluSz6 |
| ADediting_699153 | chr18_79984376_- | SINE | Alu | Name=AluSz6 |
| ADediting_699154 | chr18_79984377_- | SINE | Alu | Name=AluSz6 |
| ADediting_699155 | chr18_79984390_- | SINE | Alu | Name=AluSz6 |
| ADediting_699156 | chr18_79984391_- | SINE | Alu | Name=AluSz6 |
| ADediting_699157 | chr18_79984408_- | SINE | Alu | Name=AluSz6 |
| ADediting_699158 | chr18_79984410_- | SINE | Alu | Name=AluSz6 |
| ADediting_699159 | chr18_79984474_- | SINE | Alu | Name=AluSz6 |
| ADediting_699160 | chr18_79984496_- | SINE | Alu | Name=AluSz6 |
| ADediting_699161 | chr18_79984501_- | SINE | Alu | Name=AluSz6 |
| ADediting_699162 | chr18_79984533_- | SINE | Alu | Name=AluSz6 |
| ADediting_699163 | chr18_79984689_- | SINE | Alu | Name=AluJo |
| ADediting_699164 | chr18_79984746_- | SINE | Alu | Name=AluJo |
| ADediting_699165 | chr18_79984747_- | SINE | Alu | Name=AluJo |
| ADediting_699166 | chr18_79984760_- | SINE | Alu | Name=AluJo |
| ADediting_699167 | chr18_79985381_- | SINE | Alu | Name=AluJb |
| ADediting_699168 | chr18_79985384_- | SINE | Alu | Name=AluJb |
| ADediting_699169 | chr18_79985413_- | SINE | Alu | Name=AluJb |
| ADediting_699170 | chr18_79985428_- | SINE | Alu | Name=AluJb |
| ADediting_699171 | chr18_79985430_- | SINE | Alu | Name=AluJb |
| ADediting_699172 | chr18_79985432_- | SINE | Alu | Name=AluJb |
| ADediting_699173 | chr18_79985454_- | SINE | Alu | Name=AluJb |
| ADediting_699174 | chr18_79986178_- | SINE | Alu | Name=AluJb |
| ADediting_699175 | chr18_79986237_- | SINE | Alu | Name=AluJb |
| ADediting_699176 | chr18_79986321_- | SINE | Alu | Name=AluJb |
| ADediting_699177 | chr18_80008092_- | SINE | Alu | Name=AluJb |
| ADediting_699178 | chr18_80008915_- | SINE | Alu | Name=AluSx4 |
| ADediting_699179 | chr18_80008916_- | SINE | Alu | Name=AluSx4 |
| ADediting_699180 | chr18_80008951_- | SINE | Alu | Name=AluSx4 |
| ADediting_699181 | chr18_80019414_- | LTR | ERVL-MaLR | Name=THE1A |
| ADediting_699182 | chr18_80019417_- | LTR | ERVL-MaLR | Name=THE1A |
| ADediting_699183 | chr18_80019423_- | LTR | ERVL-MaLR | Name=THE1A |
| ADediting_699184 | chr18_80019432_- | LTR | ERVL-MaLR | Name=THE1A |
| ADediting_699185 | chr18_80019442_- | LTR | ERVL-MaLR | Name=THE1A |
| ADediting_699186 | chr18_80020010_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_699187 | chr18_80020039_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_699188 | chr18_80020062_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_699189 | chr18_80020063_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_699190 | chr18_80020074_- | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_699191 | chr18_80030801_- | SINE | Alu | Name=AluSz |
| ADediting_699192 | chr18_80030843_- | SINE | Alu | Name=AluSz |
| ADediting_699193 | chr18_80030855_- | SINE | Alu | Name=AluSz |
| ADediting_699194 | chr18_80032647_- | SINE | Alu | Name=AluSz |
| ADediting_1551224 | chr18_79977901_- | SINE | Alu | Name=AluJb |
| ADediting_1551225 | chr18_79983098_- | SINE | Alu | Name=AluSx1 |
| ADediting_1551226 | chr18_79983183_- | SINE | Alu | Name=AluSx1 |
| ADediting_1551227 | chr18_79983189_- | SINE | Alu | Name=AluSx1 |
| ADediting_1551228 | chr18_79983204_- | SINE | Alu | Name=AluSx1 |
| ADediting_1551229 | chr18_79984427_- | SINE | Alu | Name=AluSz6 |
| ADediting_1551230 | chr18_79984445_- | SINE | Alu | Name=AluSz6 |
| ADediting_1551231 | chr18_79985303_- | SINE | Alu | Name=AluJb |
| ADediting_1551232 | chr18_79985446_- | SINE | Alu | Name=AluJb |
| ADediting_1551233 | chr18_79985468_- | SINE | Alu | Name=AluJb |
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RNA A-to-I editing events in the alternative splicing sites for TXNL4A |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TXNL4A |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for TXNL4A |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for TXNL4A |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_699098 | chr18_79971400_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-24-1-5p | chr18 | 79971398 | 79971404 | 7mer-m8 | 79971397 | 79971421 | 161 | -20.89 |
| ADediting_699098 | chr18_79971400_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-24-2-5p | chr18 | 79971398 | 79971404 | 7mer-m8 | 79971397 | 79971419 | 153 | -19.82 |
| ADediting_699099 | chr18_79971401_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-4284 | chr18 | 79971396 | 79971403 | 8mer-1a | 79971396 | 79971413 | 151 | -16.56 |
| ADediting_699100 | chr18_79971411_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-4732-3p | chr18 | 79971409 | 79971415 | 7mer-m8 | 79971408 | 79971428 | 154 | -23.77 |
| ADediting_699100 | chr18_79971411_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-6779-3p | chr18 | 79971407 | 79971413 | 7mer-m8 | 79971406 | 79971426 | 150 | -20.42 |
| ADediting_699100 | chr18_79971411_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-7976 | chr18 | 79971408 | 79971414 | 7mer-m8 | 79971407 | 79971423 | 149 | -17.97 |
| ADediting_699101 | chr18_79971419_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-4508 | chr18 | 79971419 | 79971425 | 7mer-m8 | 79971418 | 79971434 | 140 | -17.35 |
| ADediting_699101 | chr18_79971419_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-6784-5p | chr18 | 79971417 | 79971424 | 8mer-1a | 79971417 | 79971435 | 163 | -28 |
| ADediting_699103 | chr18_79972668_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-3190-5p | chr18 | 79972668 | 79972674 | 7mer-m8 | 79972667 | 79972686 | 154 | -19.64 |
| ADediting_699104 | chr18_79972736_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-513a-5p | chr18 | 79972735 | 79972741 | 7mer-m8 | 79972734 | 79972751 | 144 | -17.77 |
| ADediting_699104 | chr18_79972736_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-638 | chr18 | 79972730 | 79972736 | 7mer-1a | 79972730 | 79972754 | 151 | -32.52 |
| ADediting_699106 | chr18_79972754_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-6720-3p | chr18 | 79972753 | 79972759 | 7mer-m8 | 79972752 | 79972775 | 145 | -21.3 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_699097 | chr18_79971396_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-135a-5p | chr18 | 79971395 | 79971401 | 7mer-m8 | 79971394 | 79971416 | 148 | -14.13 |
| ADediting_699097 | chr18_79971396_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-135b-5p | chr18 | 79971395 | 79971401 | 7mer-m8 | 79971394 | 79971418 | 144 | -14.13 |
| ADediting_699097 | chr18_79971396_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-7153-3p | chr18 | 79971392 | 79971398 | 7mer-m8 | 79971391 | 79971408 | 140 | -13.13 |
| ADediting_699098 | chr18_79971400_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-135a-5p | chr18 | 79971395 | 79971401 | 7mer-m8 | 79971394 | 79971416 | 148 | -14.13 |
| ADediting_699098 | chr18_79971400_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-135b-5p | chr18 | 79971395 | 79971401 | 7mer-m8 | 79971394 | 79971418 | 144 | -14.13 |
| ADediting_699100 | chr18_79971411_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-10397-5p | chr18 | 79971409 | 79971415 | 7mer-m8 | 79971408 | 79971431 | 155 | -22.72 |
| ADediting_699101 | chr18_79971419_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-326 | chr18 | 79971416 | 79971422 | 7mer-m8 | 79971415 | 79971440 | 145 | -27.54 |
| ADediting_699101 | chr18_79971419_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-330-5p | chr18 | 79971416 | 79971422 | 7mer-m8 | 79971415 | 79971440 | 152 | -22.06 |
| ADediting_699102 | chr18_79971425_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-27a-5p | chr18 | 79971421 | 79971427 | 7mer-m8 | 79971420 | 79971441 | 153 | -17.27 |
| ADediting_699102 | chr18_79971425_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-4720-3p | chr18 | 79971423 | 79971429 | 7mer-m8 | 79971422 | 79971442 | 150 | -11.62 |
| ADediting_699103 | chr18_79972668_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-4716-5p | chr18 | 79972663 | 79972669 | 7mer-m8 | 79972662 | 79972683 | 140 | -11.3 |
| ADediting_699103 | chr18_79972668_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-4781-3p | chr18 | 79972665 | 79972671 | 7mer-m8 | 79972664 | 79972682 | 144 | -13.86 |
| ADediting_699104 | chr18_79972736_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-10399-5p | chr18 | 79972734 | 79972740 | 7mer-m8 | 79972733 | 79972754 | 148 | -11.21 |
| ADediting_699104 | chr18_79972736_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-6504-3p | chr18 | 79972734 | 79972740 | 7mer-m8 | 79972733 | 79972754 | 145 | -14.35 |
| ADediting_699105 | chr18_79972742_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-3934-5p | chr18 | 79972738 | 79972744 | 7mer-m8 | 79972737 | 79972759 | 155 | -24.94 |
| ADediting_699105 | chr18_79972742_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-552-3p | chr18 | 79972736 | 79972743 | 8mer-1a | 79972736 | 79972756 | 140 | -13.45 |
| ADediting_699106 | chr18_79972754_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-1271-3p | chr18 | 79972753 | 79972759 | 7mer-m8 | 79972752 | 79972774 | 142 | -17.57 |
| ADediting_699107 | chr18_79972758_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-1271-3p | chr18 | 79972753 | 79972759 | 7mer-m8 | 79972752 | 79972774 | 142 | -17.57 |
| ADediting_699107 | chr18_79972758_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-3190-5p | chr18 | 79972757 | 79972763 | 7mer-m8 | 79972756 | 79972774 | 144 | -16.24 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-337-3p | chr18 | 79973595 | 79973602 | 8mer-1a | 79973595 | 79973616 | 146 | -13.53 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000141759.15 | ENST00000585474.5 | TXNL4A-203 | hsa-miR-337-3p | chr18 | 79973595 | 79973602 | 8mer-1a | 79973595 | 79973616 | 146 | -13.53 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000141759.15 | ENST00000588162.1 | TXNL4A-208 | hsa-miR-337-3p | chr18 | 79973595 | 79973602 | 8mer-1a | 79973595 | 79973616 | 146 | -13.53 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000141759.15 | ENST00000592837.1 | TXNL4A-211 | hsa-miR-337-3p | chr18 | 79973595 | 79973602 | 8mer-1a | 79973595 | 79973616 | 146 | -13.53 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000141759.15 | ENST00000592957.1 | TXNL4A-212 | hsa-miR-337-3p | chr18 | 79973595 | 79973602 | 8mer-1a | 79973595 | 79973616 | 146 | -13.53 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-381-3p | chr18 | 79973388 | 79973394 | 7mer-1a | 79973388 | 79973412 | 140 | -18.87 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000141759.15 | ENST00000585474.5 | TXNL4A-203 | hsa-miR-381-3p | chr18 | 79973388 | 79973394 | 7mer-1a | 79973388 | 79973412 | 140 | -18.87 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-641 | chr18 | 79970868 | 79970874 | 7mer-m8 | 79970867 | 79970891 | 157 | -20.53 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-641 | chr18 | 79972460 | 79972466 | 7mer-m8 | 79972459 | 79972482 | 140 | -12.45 |
| ADediting_286380 | chr11_79422188_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-5579-3p | chr18 | 79971396 | 79971402 | 7mer-m8 | 79971395 | 79971417 | 141 | -16.7 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-5688 | chr18 | 79973494 | 79973500 | 7mer-m8 | 79973493 | 79973514 | 145 | -12.5 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000141759.15 | ENST00000585474.5 | TXNL4A-203 | hsa-miR-5688 | chr18 | 79973494 | 79973500 | 7mer-m8 | 79973493 | 79973514 | 145 | -12.5 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000141759.15 | ENST00000588162.1 | TXNL4A-208 | hsa-miR-5688 | chr18 | 79973494 | 79973500 | 7mer-m8 | 79973493 | 79973514 | 145 | -12.5 |
| ADediting_291761 | chr11_93733708_- | ENSG00000141759.15 | ENST00000269601.10 | TXNL4A-201 | hsa-miR-1304-3p | chr18 | 79971774 | 79971781 | 8mer-1a | 79971774 | 79971795 | 153 | -15.34 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for TXNL4A |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000269601.10 | protein_coding |  |  |
| ENST00000592837.1 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_699097 | ENST00000269601.10 | chr18_79971396_- | 2889 | -1215.90 | -1216.00 | -1228.80 |
| ADediting_699098 | ENST00000269601.10 | chr18_79971400_- | 2885 | -1217.40 | -1216.00 | -1228.80 |
| ADediting_699099 | ENST00000269601.10 | chr18_79971401_- | 2884 | -1217.50 | -1216.00 | -1228.80 |
| ADediting_699100 | ENST00000269601.10 | chr18_79971411_- | 2874 | -1216.40 | -1216.00 | -1228.80 |
| ADediting_699101 | ENST00000269601.10 | chr18_79971419_- | 2866 | -1217.90 | -1216.00 | -1228.80 |
| ADediting_699102 | ENST00000269601.10 | chr18_79971425_- | 2860 | -1219.60 | -1216.00 | -1228.80 |
| ADediting_699103 | ENST00000269601.10 | chr18_79972668_- | 1617 | -1215.70 | -1216.00 | -1228.80 |
| ADediting_699104 | ENST00000269601.10 | chr18_79972736_- | 1549 | -1221.30 | -1216.00 | -1228.80 |
| ADediting_699105 | ENST00000269601.10 | chr18_79972742_- | 1543 | -1215.60 | -1216.00 | -1228.80 |
| ADediting_699106 | ENST00000269601.10 | chr18_79972754_- | 1531 | -1216.20 | -1216.00 | -1228.80 |
| ADediting_699107 | ENST00000269601.10 | chr18_79972758_- | 1527 | -1215.30 | -1216.00 | -1228.80 |
| ADediting_1551224 | ENST00000592837.1 | chr18_79977901_- | 17 | -183.50 | -183.50 | -183.50 |
| ADediting_699122 | ENST00000592837.1 | chr18_79977907_- | 11 | -183.50 | -183.50 | -183.50 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for TXNL4A |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_699099 | chr18_79971401_- | 0.00704403675132606 | 0.219177407047117 | 2.96514789328706e-07 | 0.403914899819418 | 0.113432563278019 | 0.129785876438611 |
| CER | ADediting_699100 | chr18_79971411_- | 0.00195132985332348 | 0.250952614359479 | 1.83527627444915e-05 | 0.342042435778789 | 0.0813559094747479 | 0.142769346833903 |
| DLPFC | ADediting_699130 | chr18_79983138_- | 0.566022551832745 | 0.0327198651477071 | 0.13210844851609 | -0.085714717882737 | 6.94209852808186e-21 | 0.498576804712199 |
| CER | ADediting_699132 | chr18_79983161_- | 0.0307837289892208 | 0.176441635614397 | 0.000145386080823451 | 0.305288141769377 | 0.479287614332303 | 0.0582008407110466 |
| DLPFC | ADediting_699141 | chr18_79983202_- | 0.0516909540112424 | 0.110615769595519 | 0.539839490062708 | -0.0349497750593631 | 1.44409854383625e-15 | 0.432571464838906 |
| DLPFC | ADediting_699142 | chr18_79983227_- | 0.171286062039703 | 0.0778984722926496 | 0.224214344601783 | -0.0692267831476646 | 2.49592812038661e-19 | 0.480700161886811 |
| CER | ADediting_699144 | chr18_79983247_- | 0.00619756251674199 | 0.222538711431032 | 1.30633744912582e-05 | 0.347656071678921 | 0.185938385557683 | 0.108585959250882 |
| CER | ADediting_699145 | chr18_79983256_- | 0.0109625164488324 | 0.207182267994512 | 7.56425180729329e-05 | 0.317411360965261 | 0.0951704802967998 | 0.136754518721606 |
| CER | ADediting_699147 | chr18_79983274_- | 0.000390720764098269 | 0.28587660700518 | 6.69715641078331e-05 | 0.319613978624476 | 0.0800714194192542 | 0.143369218200433 |
| DLPFC | ADediting_699149 | chr18_79983281_- | 0.0212988772415298 | 0.130747694342904 | 0.889236869492357 | 0.00794195799246086 | 1.02925826637221e-12 | 0.390180605097311 |
| CER | ADediting_699149 | chr18_79983281_- | 0.000618861311495702 | 0.276352258464529 | 4.62161300063761e-05 | 0.326221620475095 | 0.0444903137673718 | 0.164327805229718 |
| CER | ADediting_699151 | chr18_79984337_- | 0.00298869835775847 | 0.240845547483005 | 6.97044898188697e-05 | 0.318892272337374 | 0.281448012638807 | 0.0885102795894261 |
| DLPFC | ADediting_699152 | chr18_79984359_- | 0.00166882418508761 | 0.177837694114256 | 0.254637563064463 | 0.0648937224374924 | 8.26866135511265e-11 | 0.358069412786165 |
| CER | ADediting_699152 | chr18_79984359_- | 0.000232890719684917 | 0.296207028543995 | 3.15811196696798e-06 | 0.370010621891812 | 0.385941842643176 | 0.0712965649101485 |
| DLPFC | ADediting_699156 | chr18_79984391_- | 0.00208582605261262 | 0.174169071741882 | 0.240792682798854 | 0.066817815414672 | 1.45880364393071e-15 | 0.432510476854202 |
| DLPFC | ADediting_699162 | chr18_79984533_- | 0.0261709697732705 | 0.126299768580194 | 0.680197808080277 | 0.0235027126321818 | 1.17789548330051e-15 | 0.433795415528565 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 2.31962416044668e-33 | 0.612888796377706 | 3.84114720764603e-49 | 0.711612822399675 | 4.97253841500067e-09 | 0.324432512107205 |
| AC | 4.74911679647215e-62 | 0.820057928441923 | 2.11838482558289e-50 | 0.770457351403662 | 1.29777828881945e-13 | 0.44585355833757 |
| PCC | 4.55678961968079e-19 | 0.586911255575295 | 1.36526302535146e-21 | 0.619046687902255 | 0.174174327754124 | 0.0987351528731798 |
| CER | 2.13282014764345e-06 | 0.375906035736041 | 8.95256265365544e-07 | 0.388548253847828 | 0.00465075090003183 | 0.229910567575627 |
| TCX | 1.29955193262134e-18 | 0.639385836875768 | 7.83237941235609e-10 | 0.47545770261439 | 0.582727584518348 | 0.0452140104074307 |
| FP | 1.71753712321164e-08 | 0.407032123010565 | 5.00601999892315e-14 | 0.525524609008002 | 0.619537768298412 | -0.0374655496369791 |
| IFG | 0.00335874743790559 | 0.563432260590428 | 0.113185055708462 | 0.324777493057041 | 0.29546845570556 | -0.21786732286106 |
| PG | 2.26369270138992e-31 | 0.722993940820988 | 1.05724067602452e-19 | 0.60172867293006 | 0.145656169665544 | -0.10710413181742 |
| STG | 2.35990860137828e-15 | 0.732632322125422 | 5.03526956757711e-12 | 0.665403307074806 | 0.648910535949211 | -0.0503982806745488 |
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Relation with AD stages for TXNL4A |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for TXNL4A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TXNL4A |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TXNL4A | C0008297 | Choanal Atresia | 1 | GENOMICS_ENGLAND |
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