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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for ALDH1L1 |
 Gene summary |
| Gene information | Gene symbol | ALDH1L1 | Gene ID | 10840 |
| Gene name | aldehyde dehydrogenase 1 family member L1 | |
| Synonyms | 10-FTHFDH|10-fTHF|FDH|FTHFD | |
| Cytomap | 3q21.3 | |
| Type of gene | protein-coding | |
| Description | cytosolic 10-formyltetrahydrofolate dehydrogenase10-formyltetrahydrofolate dehydrogenaseMER57B-ALDH1L1 | |
| Modification date | 20200313 | |
| UniProtAcc | O75891, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for ALDH1L1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1019265(126115643, -), ADediting_1019266(126115644, -), ADediting_1019267(126115671, -), ADediting_1019268(126115681, -), ADediting_1019269(126115686, -), ADediting_1019270(126115707, -), ADediting_1019271(126115712, -), ADediting_1019272(126115713, -), ADediting_1019273(126115723, -), ADediting_1019274(126115739, -), ADediting_1019275(126115751, -), ADediting_1019276(126115752, -), ADediting_1019277(126115769, -), ADediting_1019278(126115776, -), ADediting_1019279(126115782, -), ADediting_1019280(126115793, -), ADediting_1019281(126115794, -), ADediting_1019282(126115812, -), ADediting_1019283(126115817, -), ADediting_1019284(126115847, -), ADediting_1019285(126115848, -), ADediting_1019286(126115895, -), ADediting_1019287(126115910, -), ADediting_1019288(126115911, -), ADediting_1019289(126115946, -), ADediting_1019290(126115951, -), ADediting_1019291(126115962, -), ADediting_1019292(126115969, -), ADediting_1019293(126115970, -), ADediting_1019294(126115978, -), ADediting_1019295(126115979, -), ADediting_1019296(126115981, -), ADediting_1019297(126115984, -), ADediting_1019298(126115996, -), ADediting_1019299(126116001, -), ADediting_1019300(126116005, -), ADediting_1019301(126116013, -), ADediting_1019302(126116021, -), ADediting_1019303(126116075, -), ADediting_1019304(126116076, -), ADediting_1019305(126116077, -), ADediting_1019306(126116083, -), ADediting_1019307(126116085, -), ADediting_1019308(126116147, -), ADediting_1019309(126116162, -), ADediting_1019310(126116305, -), ADediting_1019311(126116324, -), ADediting_1019312(126116362, -), ADediting_1019313(126116366, -), ADediting_1019315(126116372, -), ADediting_1019316(126116382, -), ADediting_1019317(126117089, -), ADediting_1019318(126117121, -), ADediting_1019319(126117123, -), ADediting_1019320(126117133, -), ADediting_1019321(126117150, -), ADediting_1019322(126117163, -), ADediting_1019323(126117183, -), ADediting_1019324(126117194, -), ADediting_1019325(126117219, -), ADediting_1019326(126117225, -), ADediting_1019327(126117429, -), ADediting_1019328(126117433, -), ADediting_1019329(126117434, -), ADediting_1019330(126117437, -), ADediting_1019331(126117438, -), ADediting_1019332(126117450, -), ADediting_1019333(126117451, -), ADediting_1019334(126117452, -), ADediting_1019335(126117461, -), ADediting_1019336(126117463, -), ADediting_1019337(126117487, -), ADediting_1019338(126117489, -), ADediting_1019339(126117491, -), ADediting_1019340(126117507, -), ADediting_1019341(126117508, -), ADediting_1019342(126117512, -), ADediting_1019343(126117524, -), ADediting_1019344(126117532, -), ADediting_1019345(126117534, -), ADediting_1019346(126117544, -), ADediting_1019347(126117547, -), ADediting_1019348(126117548, -), ADediting_1019349(126117556, -), ADediting_1019350(126117569, -), ADediting_1019351(126117590, -), ADediting_1019352(126117595, -), ADediting_1019353(126117600, -), ADediting_1019354(126117630, -), ADediting_1019355(126117646, -), ADediting_1019360(126171215, -), ADediting_1019361(126171222, -), ADediting_1019370(126174176, -), ADediting_1571991(126115680, -), ADediting_1571992(126115683, -), ADediting_1571993(126115703, -), ADediting_1571994(126116086, -), |
Top |
RNA editing positional annotations for ALDH1L1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1019265 | chr3_126115643_- | intronic |
| ADediting_1019266 | chr3_126115644_- | intronic |
| ADediting_1019267 | chr3_126115671_- | intronic |
| ADediting_1019268 | chr3_126115681_- | intronic |
| ADediting_1019269 | chr3_126115686_- | intronic |
| ADediting_1019270 | chr3_126115707_- | intronic |
| ADediting_1019271 | chr3_126115712_- | intronic |
| ADediting_1019272 | chr3_126115713_- | intronic |
| ADediting_1019273 | chr3_126115723_- | intronic |
| ADediting_1019274 | chr3_126115739_- | intronic |
| ADediting_1019275 | chr3_126115751_- | intronic |
| ADediting_1019276 | chr3_126115752_- | intronic |
| ADediting_1019277 | chr3_126115769_- | intronic |
| ADediting_1019278 | chr3_126115776_- | intronic |
| ADediting_1019279 | chr3_126115782_- | intronic |
| ADediting_1019280 | chr3_126115793_- | intronic |
| ADediting_1019281 | chr3_126115794_- | intronic |
| ADediting_1019282 | chr3_126115812_- | intronic |
| ADediting_1019283 | chr3_126115817_- | intronic |
| ADediting_1019284 | chr3_126115847_- | intronic |
| ADediting_1019285 | chr3_126115848_- | intronic |
| ADediting_1019286 | chr3_126115895_- | intronic |
| ADediting_1019287 | chr3_126115910_- | intronic |
| ADediting_1019288 | chr3_126115911_- | intronic |
| ADediting_1019289 | chr3_126115946_- | intronic |
| ADediting_1019290 | chr3_126115951_- | intronic |
| ADediting_1019291 | chr3_126115962_- | intronic |
| ADediting_1019292 | chr3_126115969_- | intronic |
| ADediting_1019293 | chr3_126115970_- | intronic |
| ADediting_1019294 | chr3_126115978_- | intronic |
| ADediting_1019295 | chr3_126115979_- | intronic |
| ADediting_1019296 | chr3_126115981_- | intronic |
| ADediting_1019297 | chr3_126115984_- | intronic |
| ADediting_1019298 | chr3_126115996_- | intronic |
| ADediting_1019299 | chr3_126116001_- | intronic |
| ADediting_1019300 | chr3_126116005_- | intronic |
| ADediting_1019301 | chr3_126116013_- | intronic |
| ADediting_1019302 | chr3_126116021_- | intronic |
| ADediting_1019303 | chr3_126116075_- | intronic |
| ADediting_1019304 | chr3_126116076_- | intronic |
| ADediting_1019305 | chr3_126116077_- | intronic |
| ADediting_1019306 | chr3_126116083_- | intronic |
| ADediting_1019307 | chr3_126116085_- | intronic |
| ADediting_1019308 | chr3_126116147_- | intronic |
| ADediting_1019309 | chr3_126116162_- | intronic |
| ADediting_1019310 | chr3_126116305_- | intronic |
| ADediting_1019311 | chr3_126116324_- | intronic |
| ADediting_1019312 | chr3_126116362_- | intronic |
| ADediting_1019313 | chr3_126116366_- | intronic |
| ADediting_1019315 | chr3_126116372_- | intronic |
| ADediting_1019316 | chr3_126116382_- | intronic |
| ADediting_1019317 | chr3_126117089_- | intronic |
| ADediting_1019318 | chr3_126117121_- | intronic |
| ADediting_1019319 | chr3_126117123_- | intronic |
| ADediting_1019320 | chr3_126117133_- | intronic |
| ADediting_1019321 | chr3_126117150_- | intronic |
| ADediting_1019322 | chr3_126117163_- | intronic |
| ADediting_1019323 | chr3_126117183_- | intronic |
| ADediting_1019324 | chr3_126117194_- | intronic |
| ADediting_1019325 | chr3_126117219_- | intronic |
| ADediting_1019326 | chr3_126117225_- | intronic |
| ADediting_1019327 | chr3_126117429_- | intronic |
| ADediting_1019328 | chr3_126117433_- | intronic |
| ADediting_1019329 | chr3_126117434_- | intronic |
| ADediting_1019330 | chr3_126117437_- | intronic |
| ADediting_1019331 | chr3_126117438_- | intronic |
| ADediting_1019332 | chr3_126117450_- | intronic |
| ADediting_1019333 | chr3_126117451_- | intronic |
| ADediting_1019334 | chr3_126117452_- | intronic |
| ADediting_1019335 | chr3_126117461_- | intronic |
| ADediting_1019336 | chr3_126117463_- | intronic |
| ADediting_1019337 | chr3_126117487_- | intronic |
| ADediting_1019338 | chr3_126117489_- | intronic |
| ADediting_1019339 | chr3_126117491_- | intronic |
| ADediting_1019340 | chr3_126117507_- | intronic |
| ADediting_1019341 | chr3_126117508_- | intronic |
| ADediting_1019342 | chr3_126117512_- | intronic |
| ADediting_1019343 | chr3_126117524_- | intronic |
| ADediting_1019344 | chr3_126117532_- | intronic |
| ADediting_1019345 | chr3_126117534_- | intronic |
| ADediting_1019346 | chr3_126117544_- | intronic |
| ADediting_1019347 | chr3_126117547_- | intronic |
| ADediting_1019348 | chr3_126117548_- | intronic |
| ADediting_1019349 | chr3_126117556_- | intronic |
| ADediting_1019350 | chr3_126117569_- | intronic |
| ADediting_1019351 | chr3_126117590_- | intronic |
| ADediting_1019352 | chr3_126117595_- | intronic |
| ADediting_1019353 | chr3_126117600_- | intronic |
| ADediting_1019354 | chr3_126117630_- | intronic |
| ADediting_1019355 | chr3_126117646_- | intronic |
| ADediting_1019360 | chr3_126171215_- | intronic |
| ADediting_1019361 | chr3_126171222_- | intronic |
| ADediting_1019370 | chr3_126174176_- | intronic |
| ADediting_1571991 | chr3_126115680_- | intronic |
| ADediting_1571992 | chr3_126115683_- | intronic |
| ADediting_1571993 | chr3_126115703_- | intronic |
| ADediting_1571994 | chr3_126116086_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1019265 | chr3_126115643_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019266 | chr3_126115644_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019267 | chr3_126115671_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019268 | chr3_126115681_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019269 | chr3_126115686_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019270 | chr3_126115707_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019271 | chr3_126115712_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019272 | chr3_126115713_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019273 | chr3_126115723_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019274 | chr3_126115739_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019275 | chr3_126115751_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019276 | chr3_126115752_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019277 | chr3_126115769_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019278 | chr3_126115776_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019279 | chr3_126115782_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019280 | chr3_126115793_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019281 | chr3_126115794_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019282 | chr3_126115812_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019283 | chr3_126115817_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019284 | chr3_126115847_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019285 | chr3_126115848_- | SINE | Alu | Name=AluSq2 |
| ADediting_1019286 | chr3_126115895_- | SINE | Alu | Name=AluSz |
| ADediting_1019287 | chr3_126115910_- | SINE | Alu | Name=AluSz |
| ADediting_1019288 | chr3_126115911_- | SINE | Alu | Name=AluSz |
| ADediting_1019289 | chr3_126115946_- | SINE | Alu | Name=AluSz |
| ADediting_1019290 | chr3_126115951_- | SINE | Alu | Name=AluSz |
| ADediting_1019291 | chr3_126115962_- | SINE | Alu | Name=AluSz |
| ADediting_1019292 | chr3_126115969_- | SINE | Alu | Name=AluSz |
| ADediting_1019293 | chr3_126115970_- | SINE | Alu | Name=AluSz |
| ADediting_1019294 | chr3_126115978_- | SINE | Alu | Name=AluSz |
| ADediting_1019295 | chr3_126115979_- | SINE | Alu | Name=AluSz |
| ADediting_1019296 | chr3_126115981_- | SINE | Alu | Name=AluSz |
| ADediting_1019297 | chr3_126115984_- | SINE | Alu | Name=AluSz |
| ADediting_1019298 | chr3_126115996_- | SINE | Alu | Name=AluSz |
| ADediting_1019299 | chr3_126116001_- | SINE | Alu | Name=AluSz |
| ADediting_1019300 | chr3_126116005_- | SINE | Alu | Name=AluSz |
| ADediting_1019301 | chr3_126116013_- | SINE | Alu | Name=AluSz |
| ADediting_1019302 | chr3_126116021_- | SINE | Alu | Name=AluSz |
| ADediting_1019303 | chr3_126116075_- | SINE | Alu | Name=AluSz |
| ADediting_1019304 | chr3_126116076_- | SINE | Alu | Name=AluSz |
| ADediting_1019305 | chr3_126116077_- | SINE | Alu | Name=AluSz |
| ADediting_1019306 | chr3_126116083_- | SINE | Alu | Name=AluSz |
| ADediting_1019307 | chr3_126116085_- | SINE | Alu | Name=AluSz |
| ADediting_1019308 | chr3_126116147_- | SINE | Alu | Name=AluSz |
| ADediting_1019309 | chr3_126116162_- | SINE | Alu | Name=AluSz |
| ADediting_1019310 | chr3_126116305_- | SINE | Alu | Name=AluSc8 |
| ADediting_1019311 | chr3_126116324_- | SINE | Alu | Name=AluSc8 |
| ADediting_1019312 | chr3_126116362_- | SINE | Alu | Name=AluSc8 |
| ADediting_1019313 | chr3_126116366_- | SINE | Alu | Name=AluSc8 |
| ADediting_1019315 | chr3_126116372_- | SINE | Alu | Name=AluSc8 |
| ADediting_1019316 | chr3_126116382_- | SINE | Alu | Name=AluSc8 |
| ADediting_1019317 | chr3_126117089_- | SINE | Alu | Name=AluJb |
| ADediting_1019318 | chr3_126117121_- | SINE | Alu | Name=AluJb |
| ADediting_1019319 | chr3_126117123_- | SINE | Alu | Name=AluJb |
| ADediting_1019320 | chr3_126117133_- | SINE | Alu | Name=AluJb |
| ADediting_1019321 | chr3_126117150_- | SINE | Alu | Name=AluJb |
| ADediting_1019322 | chr3_126117163_- | SINE | Alu | Name=AluJb |
| ADediting_1019323 | chr3_126117183_- | SINE | Alu | Name=AluJb |
| ADediting_1019324 | chr3_126117194_- | SINE | Alu | Name=AluJb |
| ADediting_1019325 | chr3_126117219_- | SINE | Alu | Name=AluJb |
| ADediting_1019326 | chr3_126117225_- | SINE | Alu | Name=AluJb |
| ADediting_1019327 | chr3_126117429_- | SINE | Alu | Name=AluJo |
| ADediting_1019328 | chr3_126117433_- | SINE | Alu | Name=AluJo |
| ADediting_1019329 | chr3_126117434_- | SINE | Alu | Name=AluJo |
| ADediting_1019330 | chr3_126117437_- | SINE | Alu | Name=AluJo |
| ADediting_1019331 | chr3_126117438_- | SINE | Alu | Name=AluJo |
| ADediting_1019332 | chr3_126117450_- | SINE | Alu | Name=AluJo |
| ADediting_1019333 | chr3_126117451_- | SINE | Alu | Name=AluJo |
| ADediting_1019334 | chr3_126117452_- | SINE | Alu | Name=AluJo |
| ADediting_1019335 | chr3_126117461_- | SINE | Alu | Name=AluJo |
| ADediting_1019336 | chr3_126117463_- | SINE | Alu | Name=AluJo |
| ADediting_1019337 | chr3_126117487_- | SINE | Alu | Name=AluJo |
| ADediting_1019338 | chr3_126117489_- | SINE | Alu | Name=AluJo |
| ADediting_1019339 | chr3_126117491_- | SINE | Alu | Name=AluJo |
| ADediting_1019340 | chr3_126117507_- | SINE | Alu | Name=AluJo |
| ADediting_1019341 | chr3_126117508_- | SINE | Alu | Name=AluJo |
| ADediting_1019342 | chr3_126117512_- | SINE | Alu | Name=AluJo |
| ADediting_1019343 | chr3_126117524_- | SINE | Alu | Name=AluJo |
| ADediting_1019344 | chr3_126117532_- | SINE | Alu | Name=AluJo |
| ADediting_1019345 | chr3_126117534_- | SINE | Alu | Name=AluJo |
| ADediting_1019346 | chr3_126117544_- | SINE | Alu | Name=AluJo |
| ADediting_1019347 | chr3_126117547_- | SINE | Alu | Name=AluJo |
| ADediting_1019348 | chr3_126117548_- | SINE | Alu | Name=AluJo |
| ADediting_1019349 | chr3_126117556_- | SINE | Alu | Name=AluJo |
| ADediting_1019350 | chr3_126117569_- | SINE | Alu | Name=AluJo |
| ADediting_1019351 | chr3_126117590_- | SINE | Alu | Name=AluJo |
| ADediting_1019352 | chr3_126117595_- | SINE | Alu | Name=AluJo |
| ADediting_1019353 | chr3_126117600_- | SINE | Alu | Name=AluJo |
| ADediting_1019354 | chr3_126117630_- | SINE | Alu | Name=AluJo |
| ADediting_1019355 | chr3_126117646_- | SINE | Alu | Name=AluJo |
| ADediting_1019360 | chr3_126171215_- | SINE | Alu | Name=AluSc8 |
| ADediting_1019361 | chr3_126171222_- | SINE | Alu | Name=AluSc8 |
| ADediting_1019370 | chr3_126174176_- | SINE | Alu | Name=AluSp |
| ADediting_1571991 | chr3_126115680_- | SINE | Alu | Name=AluSq2 |
| ADediting_1571992 | chr3_126115683_- | SINE | Alu | Name=AluSq2 |
| ADediting_1571993 | chr3_126115703_- | SINE | Alu | Name=AluSq2 |
| ADediting_1571994 | chr3_126116086_- | SINE | Alu | Name=AluSz |
Top |
RNA A-to-I editing events in the alternative splicing sites for ALDH1L1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ALDH1L1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for ALDH1L1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for ALDH1L1 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000144908.13 | ENST00000393431.6 | ALDH1L1-202 | hsa-miR-5688 | chr3 | 126105798 | 126105805 | 8mer-1a | 126105798 | 126105819 | 150 | -17.57 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000144908.13 | ENST00000455064.6 | ALDH1L1-206 | hsa-miR-5688 | chr3 | 126105798 | 126105805 | 8mer-1a | 126105798 | 126105819 | 150 | -17.57 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000144908.13 | ENST00000393431.6 | ALDH1L1-202 | hsa-miR-381-3p | chr3 | 126105835 | 126105841 | 7mer-m8 | 126105834 | 126105855 | 148 | -16.5 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000144908.13 | ENST00000455064.6 | ALDH1L1-206 | hsa-miR-381-3p | chr3 | 126105835 | 126105841 | 7mer-m8 | 126105834 | 126105855 | 148 | -16.5 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000144908.13 | ENST00000393431.6 | ALDH1L1-202 | hsa-miR-5585-3p | chr3 | 126112804 | 126112810 | 7mer-m8 | 126112803 | 126112824 | 144 | -14.62 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000144908.13 | ENST00000455064.6 | ALDH1L1-206 | hsa-miR-5585-3p | chr3 | 126112804 | 126112810 | 7mer-m8 | 126112803 | 126112824 | 144 | -14.62 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_496066 | chr15_66496985_- | ENSG00000144908.13 | ENST00000393431.6 | ALDH1L1-202 | hsa-miR-4512 | chr3 | 126105839 | 126105845 | 7mer-m8 | 126105838 | 126105860 | 146 | -24.27 |
| ADediting_496066 | chr15_66496985_- | ENSG00000144908.13 | ENST00000455064.6 | ALDH1L1-206 | hsa-miR-4512 | chr3 | 126105839 | 126105845 | 7mer-m8 | 126105838 | 126105860 | 146 | -24.27 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000144908.13 | ENST00000273450.7 | ALDH1L1-201 | hsa-miR-1273h-3p | chr3 | 126103657 | 126103663 | 7mer-m8 | 126103656 | 126103677 | 140 | -17.56 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000144908.13 | ENST00000393431.6 | ALDH1L1-202 | hsa-miR-1273h-3p | chr3 | 126103657 | 126103663 | 7mer-m8 | 126103656 | 126103677 | 140 | -17.56 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000144908.13 | ENST00000393434.6 | ALDH1L1-203 | hsa-miR-1273h-3p | chr3 | 126103657 | 126103663 | 7mer-m8 | 126103656 | 126103677 | 140 | -17.56 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000144908.13 | ENST00000452905.6 | ALDH1L1-205 | hsa-miR-1273h-3p | chr3 | 126103657 | 126103663 | 7mer-m8 | 126103656 | 126103677 | 140 | -17.56 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000144908.13 | ENST00000455064.6 | ALDH1L1-206 | hsa-miR-1273h-3p | chr3 | 126103657 | 126103663 | 7mer-m8 | 126103656 | 126103677 | 140 | -17.56 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000144908.13 | ENST00000472186.5 | ALDH1L1-210 | hsa-miR-1273h-3p | chr3 | 126103657 | 126103663 | 7mer-m8 | 126103656 | 126103677 | 140 | -17.56 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for ALDH1L1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for ALDH1L1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_1019267 | chr3_126115671_- | 0.510869130434201 | 0.0374809272836874 | 0.512999327597606 | -0.037292345797873 | 1.42683394395331e-08 | 0.315075661944998 |
| CER | ADediting_1019271 | chr3_126115712_- | 0.196000895926622 | 0.106164892453339 | 0.422785614067707 | 0.0659304770312583 | 0.000162367299920789 | 0.303185575890215 |
| CER | ADediting_1019273 | chr3_126115723_- | 0.347615228368975 | 0.0772187941735522 | 0.594564420834032 | 0.0438022267852851 | 5.96759315164141e-05 | 0.321684988329682 |
| DLPFC | ADediting_1019283 | chr3_126115817_- | 0.536166192190216 | 0.0352668385919766 | 0.479867283178559 | -0.0402738275284704 | 2.61890351213377e-08 | 0.309534779380016 |
| CER | ADediting_1019301 | chr3_126116013_- | 0.0693999732989541 | 0.148678650966163 | 0.0631633813121439 | 0.152096792732171 | 0.000178024845631191 | 0.301421114528556 |
| DLPFC | ADediting_1019316 | chr3_126116382_- | 0.186173572796941 | 0.0752811629917373 | 0.779854320666532 | -0.0159384167508596 | 2.21458714933124e-08 | 0.311076172706336 |
| DLPFC | ADediting_1019317 | chr3_126117089_- | 0.0536952634650853 | 0.109688397651927 | 0.889673289426722 | -0.00791046482573349 | 1.32830077096327e-13 | 0.404048519271105 |
| DLPFC | ADediting_1019326 | chr3_126117225_- | 0.849846544187921 | 0.0107956240254256 | 0.250560555824169 | -0.0654525988130238 | 1.47730189964004e-08 | 0.314761572034839 |
| CER | ADediting_1019330 | chr3_126117437_- | 0.0956595625371214 | 0.136554675898138 | 0.0335460527123232 | 0.173676987884782 | 0.000154417163412886 | 0.304143073591422 |
| DLPFC | ADediting_1019343 | chr3_126117524_- | 0.981252337258541 | -0.00134005923645062 | 0.091896096659004 | -0.0958954656593173 | 1.36943923233406e-08 | 0.315446185560842 |
| DLPFC | ADediting_1019344 | chr3_126117532_- | 0.204090347453329 | 0.0723279247843306 | 0.386225715632954 | -0.0493823496110368 | 4.39421362909581e-08 | 0.304720964694239 |
| CER | ADediting_1019348 | chr3_126117548_- | 0.0116988488659433 | 0.205366002168819 | 0.00345159598068809 | 0.23733748753416 | 0.000102851964002831 | 0.311775004848579 |
| CER | ADediting_1019351 | chr3_126117590_- | 0.0648650760071318 | 0.151137747176644 | 0.00526893112321365 | 0.226734000452792 | 1.03200381675676e-05 | 0.35148629950124 |
| CER | ADediting_1019352 | chr3_126117595_- | 0.237975267235214 | 0.0969355386207954 | 0.266404639029744 | 0.0913180045741867 | 4.4622046932552e-05 | 0.326839045098876 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 6.60038247342697e-06 | 0.252786590069155 | 0.0206694339468573 | 0.131385159441883 | 1.16046083959498e-22 | 0.517787489382783 |
| AC | 2.98449366532407e-23 | 0.573379625128911 | 9.1039738320347e-10 | 0.374992347881998 | 1.25806277363739e-42 | 0.728494544549308 |
| PCC | 0.0143063437878156 | 0.176998216821927 | 0.437335979987474 | 0.056526116598491 | 2.91814127437771e-13 | 0.49611953221091 |
| CER | 0.0575424472502018 | 0.155422899307692 | 0.512557361089533 | -0.0538810424137067 | 5.31877545211675e-07 | 0.395885803417371 |
| FP | 0.00165095216249362 | 0.234219512824628 | 0.419236396909803 | -0.060916095493928 | 6.88617586023248e-10 | 0.44149603956534 |
| IFG | 0.0546220638545616 | 0.388994413172406 | 0.148091716228037 | 0.297896990176833 | 0.0130112282674147 | 0.489487917246831 |
| PG | 0.0845033384245002 | -0.126836624030721 | 0.0052109380025994 | -0.204059478477446 | 1.64784390487418e-05 | 0.310139946856134 |
| STG | 0.000832014511122757 | 0.357841305169274 | 0.716918855621542 | 0.0401462829762891 | 1.47752623094815e-05 | 0.453485804009389 |
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Relation with AD stages for ALDH1L1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_1019315 | chr3_126116372_- | 0.000692449452831704 | 0.321478546765725 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 2.50230415578184e-08 | 0.509137318916369 |
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RelatedDrugs for ALDH1L1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ALDH1L1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| ALDH1L1 | C0003129 | Anoxemia | 1 | CTD_human |
| ALDH1L1 | C0003130 | Anoxia | 1 | CTD_human |
| ALDH1L1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| ALDH1L1 | C0028754 | Obesity | 1 | CTD_human |
| ALDH1L1 | C0242184 | Hypoxia | 1 | CTD_human |
| ALDH1L1 | C0700292 | Hypoxemia | 1 | CTD_human |
| ALDH1L1 | C1527249 | Colorectal Cancer | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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