|
||||||
|
 | |
| |
| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
| |
| |
| The effects of the RNA editing to the stability of the RNA structures |
| |
| |
| |
|
Gene summary for ADCY2 |
 Gene summary |
| Gene information | Gene symbol | ADCY2 | Gene ID | 108 |
| Gene name | adenylate cyclase 2 | |
| Synonyms | AC2|HBAC2 | |
| Cytomap | 5p15.31 | |
| Type of gene | protein-coding | |
| Description | adenylate cyclase type 23',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 2adenylate cyclase 2 (brain)adenylate cyclase IIadenylate cyclase type IIadenylyl cyclase 2type II adenylate cyclase | |
| Modification date | 20200313 | |
| UniProtAcc | Q08462, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for ADCY2 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_1212585(7416458, +), ADediting_1212586(7416480, +), ADediting_1212587(7416483, +), ADediting_1212588(7416486, +), ADediting_1212589(7416487, +), ADediting_1212590(7416496, +), ADediting_1212591(7416497, +), ADediting_1212592(7416499, +), ADediting_1212593(7416501, +), ADediting_1212594(7416502, +), ADediting_1212595(7416505, +), ADediting_1212596(7416510, +), ADediting_1212597(7416511, +), ADediting_1212598(7416512, +), ADediting_1212599(7416514, +), ADediting_1212600(7416517, +), ADediting_1212601(7416527, +), ADediting_1212602(7416528, +), ADediting_1212603(7416591, +), ADediting_1212604(7416594, +), ADediting_1212605(7416595, +), ADediting_1212606(7416618, +), ADediting_1212607(7416620, +), ADediting_1212608(7416650, +), ADediting_1212609(7417327, +), ADediting_1212610(7417439, +), ADediting_1212611(7417462, +), ADediting_1212612(7423552, +), ADediting_1212613(7423629, +), ADediting_1212614(7423630, +), ADediting_1212615(7427276, +), ADediting_1212616(7427299, +), ADediting_1212617(7427309, +), ADediting_1212618(7427328, +), ADediting_1212619(7427341, +), ADediting_1212620(7427491, +), ADediting_1212621(7427570, +), ADediting_1212794(7480106, +), ADediting_1212795(7480112, +), ADediting_1212796(7480161, +), ADediting_1212797(7480173, +), ADediting_1212798(7480330, +), ADediting_1212799(7480408, +), ADediting_1212805(7481006, +), ADediting_1212826(7481205, +), ADediting_1212849(7482501, +), ADediting_1213028(7511966, +), ADediting_1213267(7552995, +), ADediting_1213268(7553077, +), ADediting_1213269(7553078, +), ADediting_1213270(7553086, +), ADediting_1213280(7553455, +), ADediting_1213281(7553598, +), ADediting_1213497(7651928, +), ADediting_1213498(7651932, +), ADediting_1213499(7651936, +), ADediting_1213500(7653501, +), ADediting_1213501(7660518, +), ADediting_1213502(7660550, +), ADediting_1213503(7660838, +), ADediting_1213504(7672511, +), ADediting_1213505(7672512, +), ADediting_1213506(7672577, +), ADediting_1213843(7754777, +), ADediting_1213844(7754805, +), ADediting_1213941(7792117, +), ADediting_1213942(7792118, +), ADediting_1213943(7792275, +), ADediting_1213944(7792284, +), ADediting_1213945(7793331, +), ADediting_1213946(7793376, +), ADediting_1213947(7798619, +), ADediting_1213948(7798697, +), ADediting_1213949(7798708, +), ADediting_1213950(7798716, +), ADediting_1213951(7798719, +), ADediting_1213952(7798721, +), ADediting_1213953(7798745, +), ADediting_1213954(7798746, +), ADediting_1213955(7798761, +), ADediting_1213956(7798789, +), ADediting_1213957(7798814, +), ADediting_1213958(7798828, +), ADediting_1213959(7798841, +), ADediting_1213960(7799154, +), ADediting_1213961(7799712, +), ADediting_1213962(7800402, +), ADediting_1213963(7800408, +), ADediting_1213964(7800409, +), ADediting_1213965(7800430, +), ADediting_1213966(7800431, +), ADediting_1213967(7800501, +), ADediting_1213968(7800505, +), ADediting_1213969(7800511, +), ADediting_1213970(7800512, +), ADediting_1213971(7800515, +), ADediting_1213972(7800541, +), ADediting_1213973(7800542, +), ADediting_1213974(7800547, +), ADediting_1213975(7800555, +), ADediting_1213976(7800568, +), ADediting_1213977(7800574, +), ADediting_1213978(7800611, +), ADediting_1213979(7800641, +), ADediting_1214020(7817668, +), ADediting_1214021(7817676, +), ADediting_1214022(7817749, +), ADediting_1214023(7818632, +), ADediting_1214024(7820278, +), ADediting_1214025(7820331, +), ADediting_1214026(7820332, +), ADediting_1214027(7820333, +), ADediting_1214028(7820334, +), ADediting_1214029(7820337, +), ADediting_1214030(7820347, +), ADediting_1214055(7825273, +), ADediting_1214059(7829828, +), ADediting_1214060(7829862, +), ADediting_1214061(7829863, +), ADediting_1214062(7829959, +), ADediting_1581944(7825008, +), ADediting_1581945(7825045, +), ADediting_1581946(7825066, +), ADediting_1581947(7825084, +), ADediting_1581948(7825126, +), ADediting_1581949(7825252, +), ADediting_1657823(7416454, +), ADediting_1657824(7416460, +), ADediting_1657825(7417305, +), ADediting_1657826(7417309, +), ADediting_1657827(7417310, +), ADediting_1657828(7417318, +), ADediting_1657829(7417338, +), ADediting_1657830(7417369, +), ADediting_1657831(7423398, +), ADediting_1657838(7480133, +), ADediting_1657839(7480354, +), ADediting_1657840(7480378, +), ADediting_1657841(7480379, +), ADediting_1657842(7480387, +), ADediting_1657843(7480392, +), ADediting_1657844(7480410, +), ADediting_1657845(7481003, +), ADediting_1657846(7481027, +), ADediting_1657928(7631053, +), ADediting_1657929(7631065, +), ADediting_1657930(7668199, +), ADediting_1657931(7668222, +), |
Top |
RNA editing positional annotations for ADCY2 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1212585 | chr5_7416458_+ | intronic |
| ADediting_1212586 | chr5_7416480_+ | intronic |
| ADediting_1212587 | chr5_7416483_+ | intronic |
| ADediting_1212588 | chr5_7416486_+ | intronic |
| ADediting_1212589 | chr5_7416487_+ | intronic |
| ADediting_1212590 | chr5_7416496_+ | intronic |
| ADediting_1212591 | chr5_7416497_+ | intronic |
| ADediting_1212592 | chr5_7416499_+ | intronic |
| ADediting_1212593 | chr5_7416501_+ | intronic |
| ADediting_1212594 | chr5_7416502_+ | intronic |
| ADediting_1212595 | chr5_7416505_+ | intronic |
| ADediting_1212596 | chr5_7416510_+ | intronic |
| ADediting_1212597 | chr5_7416511_+ | intronic |
| ADediting_1212598 | chr5_7416512_+ | intronic |
| ADediting_1212599 | chr5_7416514_+ | intronic |
| ADediting_1212600 | chr5_7416517_+ | intronic |
| ADediting_1212601 | chr5_7416527_+ | intronic |
| ADediting_1212602 | chr5_7416528_+ | intronic |
| ADediting_1212603 | chr5_7416591_+ | intronic |
| ADediting_1212604 | chr5_7416594_+ | intronic |
| ADediting_1212605 | chr5_7416595_+ | intronic |
| ADediting_1212606 | chr5_7416618_+ | intronic |
| ADediting_1212607 | chr5_7416620_+ | intronic |
| ADediting_1212608 | chr5_7416650_+ | intronic |
| ADediting_1212609 | chr5_7417327_+ | intronic |
| ADediting_1212610 | chr5_7417439_+ | intronic |
| ADediting_1212611 | chr5_7417462_+ | intronic |
| ADediting_1212612 | chr5_7423552_+ | intronic |
| ADediting_1212613 | chr5_7423629_+ | intronic |
| ADediting_1212614 | chr5_7423630_+ | intronic |
| ADediting_1212615 | chr5_7427276_+ | intronic |
| ADediting_1212616 | chr5_7427299_+ | intronic |
| ADediting_1212617 | chr5_7427309_+ | intronic |
| ADediting_1212618 | chr5_7427328_+ | intronic |
| ADediting_1212619 | chr5_7427341_+ | intronic |
| ADediting_1212620 | chr5_7427491_+ | intronic |
| ADediting_1212621 | chr5_7427570_+ | intronic |
| ADediting_1212794 | chr5_7480106_+ | intronic |
| ADediting_1212795 | chr5_7480112_+ | intronic |
| ADediting_1212796 | chr5_7480161_+ | intronic |
| ADediting_1212797 | chr5_7480173_+ | intronic |
| ADediting_1212798 | chr5_7480330_+ | intronic |
| ADediting_1212799 | chr5_7480408_+ | intronic |
| ADediting_1212805 | chr5_7481006_+ | intronic |
| ADediting_1212826 | chr5_7481205_+ | intronic |
| ADediting_1212849 | chr5_7482501_+ | intronic |
| ADediting_1213028 | chr5_7511966_+ | intronic |
| ADediting_1213267 | chr5_7552995_+ | intronic |
| ADediting_1213268 | chr5_7553077_+ | intronic |
| ADediting_1213269 | chr5_7553078_+ | intronic |
| ADediting_1213270 | chr5_7553086_+ | intronic |
| ADediting_1213280 | chr5_7553455_+ | intronic |
| ADediting_1213281 | chr5_7553598_+ | intronic |
| ADediting_1213497 | chr5_7651928_+ | intronic |
| ADediting_1213498 | chr5_7651932_+ | intronic |
| ADediting_1213499 | chr5_7651936_+ | intronic |
| ADediting_1213500 | chr5_7653501_+ | intronic |
| ADediting_1213501 | chr5_7660518_+ | intronic |
| ADediting_1213502 | chr5_7660550_+ | intronic |
| ADediting_1213503 | chr5_7660838_+ | intronic |
| ADediting_1213504 | chr5_7672511_+ | intronic |
| ADediting_1213505 | chr5_7672512_+ | intronic |
| ADediting_1213506 | chr5_7672577_+ | intronic |
| ADediting_1213843 | chr5_7754777_+ | intronic |
| ADediting_1213844 | chr5_7754805_+ | intronic |
| ADediting_1213941 | chr5_7792117_+ | intronic |
| ADediting_1213942 | chr5_7792118_+ | intronic |
| ADediting_1213943 | chr5_7792275_+ | intronic |
| ADediting_1213944 | chr5_7792284_+ | intronic |
| ADediting_1213945 | chr5_7793331_+ | intronic |
| ADediting_1213946 | chr5_7793376_+ | intronic |
| ADediting_1213947 | chr5_7798619_+ | intronic |
| ADediting_1213948 | chr5_7798697_+ | intronic |
| ADediting_1213949 | chr5_7798708_+ | intronic |
| ADediting_1213950 | chr5_7798716_+ | intronic |
| ADediting_1213951 | chr5_7798719_+ | intronic |
| ADediting_1213952 | chr5_7798721_+ | intronic |
| ADediting_1213953 | chr5_7798745_+ | intronic |
| ADediting_1213954 | chr5_7798746_+ | intronic |
| ADediting_1213955 | chr5_7798761_+ | intronic |
| ADediting_1213956 | chr5_7798789_+ | intronic |
| ADediting_1213957 | chr5_7798814_+ | intronic |
| ADediting_1213958 | chr5_7798828_+ | intronic |
| ADediting_1213959 | chr5_7798841_+ | intronic |
| ADediting_1213960 | chr5_7799154_+ | intronic |
| ADediting_1213961 | chr5_7799712_+ | intronic |
| ADediting_1213962 | chr5_7800402_+ | intronic |
| ADediting_1213963 | chr5_7800408_+ | intronic |
| ADediting_1213964 | chr5_7800409_+ | intronic |
| ADediting_1213965 | chr5_7800430_+ | intronic |
| ADediting_1213966 | chr5_7800431_+ | intronic |
| ADediting_1213967 | chr5_7800501_+ | intronic |
| ADediting_1213968 | chr5_7800505_+ | intronic |
| ADediting_1213969 | chr5_7800511_+ | intronic |
| ADediting_1213970 | chr5_7800512_+ | intronic |
| ADediting_1213971 | chr5_7800515_+ | intronic |
| ADediting_1213972 | chr5_7800541_+ | intronic |
| ADediting_1213973 | chr5_7800542_+ | intronic |
| ADediting_1213974 | chr5_7800547_+ | intronic |
| ADediting_1213975 | chr5_7800555_+ | intronic |
| ADediting_1213976 | chr5_7800568_+ | intronic |
| ADediting_1213977 | chr5_7800574_+ | intronic |
| ADediting_1213978 | chr5_7800611_+ | intronic |
| ADediting_1213979 | chr5_7800641_+ | intronic |
| ADediting_1214020 | chr5_7817668_+ | intronic |
| ADediting_1214021 | chr5_7817676_+ | intronic |
| ADediting_1214022 | chr5_7817749_+ | intronic |
| ADediting_1214023 | chr5_7818632_+ | intronic |
| ADediting_1214024 | chr5_7820278_+ | intronic |
| ADediting_1214025 | chr5_7820331_+ | intronic |
| ADediting_1214026 | chr5_7820332_+ | intronic |
| ADediting_1214027 | chr5_7820333_+ | intronic |
| ADediting_1214028 | chr5_7820334_+ | intronic |
| ADediting_1214029 | chr5_7820337_+ | intronic |
| ADediting_1214030 | chr5_7820347_+ | intronic |
| ADediting_1214055 | chr5_7825273_+ | intronic |
| ADediting_1214059 | chr5_7829828_+ | UTR3 |
| ADediting_1214060 | chr5_7829862_+ | UTR3 |
| ADediting_1214061 | chr5_7829863_+ | UTR3 |
| ADediting_1214062 | chr5_7829959_+ | UTR3 |
| ADediting_1581944 | chr5_7825008_+ | intronic |
| ADediting_1581945 | chr5_7825045_+ | intronic |
| ADediting_1581946 | chr5_7825066_+ | intronic |
| ADediting_1581947 | chr5_7825084_+ | intronic |
| ADediting_1581948 | chr5_7825126_+ | intronic |
| ADediting_1581949 | chr5_7825252_+ | intronic |
| ADediting_1657823 | chr5_7416454_+ | intronic |
| ADediting_1657824 | chr5_7416460_+ | intronic |
| ADediting_1657825 | chr5_7417305_+ | intronic |
| ADediting_1657826 | chr5_7417309_+ | intronic |
| ADediting_1657827 | chr5_7417310_+ | intronic |
| ADediting_1657828 | chr5_7417318_+ | intronic |
| ADediting_1657829 | chr5_7417338_+ | intronic |
| ADediting_1657830 | chr5_7417369_+ | intronic |
| ADediting_1657831 | chr5_7423398_+ | intronic |
| ADediting_1657838 | chr5_7480133_+ | intronic |
| ADediting_1657839 | chr5_7480354_+ | intronic |
| ADediting_1657840 | chr5_7480378_+ | intronic |
| ADediting_1657841 | chr5_7480379_+ | intronic |
| ADediting_1657842 | chr5_7480387_+ | intronic |
| ADediting_1657843 | chr5_7480392_+ | intronic |
| ADediting_1657844 | chr5_7480410_+ | intronic |
| ADediting_1657845 | chr5_7481003_+ | intronic |
| ADediting_1657846 | chr5_7481027_+ | intronic |
| ADediting_1657928 | chr5_7631053_+ | intronic |
| ADediting_1657929 | chr5_7631065_+ | intronic |
| ADediting_1657930 | chr5_7668199_+ | intronic |
| ADediting_1657931 | chr5_7668222_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1212586 | chr5_7416480_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212587 | chr5_7416483_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212588 | chr5_7416486_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212589 | chr5_7416487_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212590 | chr5_7416496_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212591 | chr5_7416497_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212592 | chr5_7416499_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212593 | chr5_7416501_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212594 | chr5_7416502_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212595 | chr5_7416505_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212596 | chr5_7416510_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212597 | chr5_7416511_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212598 | chr5_7416512_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212599 | chr5_7416514_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212600 | chr5_7416517_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212601 | chr5_7416527_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212602 | chr5_7416528_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212603 | chr5_7416591_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212604 | chr5_7416594_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212605 | chr5_7416595_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212606 | chr5_7416618_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212607 | chr5_7416620_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212608 | chr5_7416650_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212609 | chr5_7417327_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212610 | chr5_7417439_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212611 | chr5_7417462_+ | LINE | L1 | Name=L1M5 |
| ADediting_1212612 | chr5_7423552_+ | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1212613 | chr5_7423629_+ | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1212614 | chr5_7423630_+ | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1212615 | chr5_7427276_+ | LTR | ERVL-MaLR | Name=THE1C |
| ADediting_1212616 | chr5_7427299_+ | LTR | ERVL-MaLR | Name=THE1C |
| ADediting_1212617 | chr5_7427309_+ | LTR | ERVL-MaLR | Name=THE1C |
| ADediting_1212618 | chr5_7427328_+ | LTR | ERVL-MaLR | Name=THE1C |
| ADediting_1212619 | chr5_7427341_+ | LTR | ERVL-MaLR | Name=THE1C |
| ADediting_1212620 | chr5_7427491_+ | LTR | ERVL-MaLR | Name=THE1C |
| ADediting_1212621 | chr5_7427570_+ | LTR | ERVL-MaLR | Name=THE1C |
| ADediting_1212794 | chr5_7480106_+ | LINE | L1 | Name=L1PA13 |
| ADediting_1212795 | chr5_7480112_+ | LINE | L1 | Name=L1PA13 |
| ADediting_1212796 | chr5_7480161_+ | LINE | L1 | Name=L1PA13 |
| ADediting_1212797 | chr5_7480173_+ | LINE | L1 | Name=L1PA13 |
| ADediting_1212798 | chr5_7480330_+ | LINE | L1 | Name=L1PA13 |
| ADediting_1212799 | chr5_7480408_+ | LINE | L1 | Name=L1PA13 |
| ADediting_1212805 | chr5_7481006_+ | LINE | L1 | Name=L1MA3 |
| ADediting_1212826 | chr5_7481205_+ | LINE | L1 | Name=L1MA3 |
| ADediting_1212849 | chr5_7482501_+ | LINE | L1 | Name=L1MA4 |
| ADediting_1213028 | chr5_7511966_+ | SINE | Alu | Name=AluSz |
| ADediting_1213497 | chr5_7651928_+ | SINE | Alu | Name=AluSc |
| ADediting_1213498 | chr5_7651932_+ | SINE | Alu | Name=AluSc |
| ADediting_1213499 | chr5_7651936_+ | SINE | Alu | Name=AluSc |
| ADediting_1213500 | chr5_7653501_+ | SINE | Alu | Name=AluY |
| ADediting_1213501 | chr5_7660518_+ | LTR | ERVL | Name=MLT2C2 |
| ADediting_1213502 | chr5_7660550_+ | LTR | ERVL | Name=MLT2C2 |
| ADediting_1213503 | chr5_7660838_+ | LTR | ERVL | Name=MLT2C2 |
| ADediting_1213504 | chr5_7672511_+ | SINE | Alu | Name=AluJb |
| ADediting_1213505 | chr5_7672512_+ | SINE | Alu | Name=AluJb |
| ADediting_1213506 | chr5_7672577_+ | SINE | Alu | Name=AluJb |
| ADediting_1213843 | chr5_7754777_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213844 | chr5_7754805_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213941 | chr5_7792117_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1213942 | chr5_7792118_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1213943 | chr5_7792275_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1213944 | chr5_7792284_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1213945 | chr5_7793331_+ | SINE | Alu | Name=AluSg |
| ADediting_1213946 | chr5_7793376_+ | SINE | Alu | Name=AluSg |
| ADediting_1213947 | chr5_7798619_+ | SINE | Alu | Name=AluYc |
| ADediting_1213948 | chr5_7798697_+ | SINE | Alu | Name=AluYc |
| ADediting_1213949 | chr5_7798708_+ | SINE | Alu | Name=AluYc |
| ADediting_1213950 | chr5_7798716_+ | SINE | Alu | Name=AluYc |
| ADediting_1213951 | chr5_7798719_+ | SINE | Alu | Name=AluYc |
| ADediting_1213952 | chr5_7798721_+ | SINE | Alu | Name=AluYc |
| ADediting_1213953 | chr5_7798745_+ | SINE | Alu | Name=AluYc |
| ADediting_1213954 | chr5_7798746_+ | SINE | Alu | Name=AluYc |
| ADediting_1213955 | chr5_7798761_+ | SINE | Alu | Name=AluYc |
| ADediting_1213956 | chr5_7798789_+ | SINE | Alu | Name=AluYc |
| ADediting_1213957 | chr5_7798814_+ | SINE | Alu | Name=AluYc |
| ADediting_1213958 | chr5_7798828_+ | SINE | Alu | Name=AluYc |
| ADediting_1213959 | chr5_7798841_+ | SINE | Alu | Name=AluYc |
| ADediting_1213961 | chr5_7799712_+ | DNA | hAT-Charlie | Name=MER5B |
| ADediting_1213962 | chr5_7800402_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213963 | chr5_7800408_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213964 | chr5_7800409_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213965 | chr5_7800430_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213966 | chr5_7800431_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213967 | chr5_7800501_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213968 | chr5_7800505_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213969 | chr5_7800511_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213970 | chr5_7800512_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213971 | chr5_7800515_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213972 | chr5_7800541_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213973 | chr5_7800542_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213974 | chr5_7800547_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213975 | chr5_7800555_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213976 | chr5_7800568_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213977 | chr5_7800574_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213978 | chr5_7800611_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1213979 | chr5_7800641_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1214020 | chr5_7817668_+ | SINE | Alu | Name=AluJb |
| ADediting_1214021 | chr5_7817676_+ | SINE | Alu | Name=AluJb |
| ADediting_1214022 | chr5_7817749_+ | SINE | Alu | Name=AluJb |
| ADediting_1214023 | chr5_7818632_+ | SINE | Alu | Name=AluSz |
| ADediting_1214024 | chr5_7820278_+ | SINE | Alu | Name=AluJb |
| ADediting_1214025 | chr5_7820331_+ | SINE | Alu | Name=AluJb |
| ADediting_1214026 | chr5_7820332_+ | SINE | Alu | Name=AluJb |
| ADediting_1214027 | chr5_7820333_+ | SINE | Alu | Name=AluJb |
| ADediting_1214028 | chr5_7820334_+ | SINE | Alu | Name=AluJb |
| ADediting_1214029 | chr5_7820337_+ | SINE | Alu | Name=AluJb |
| ADediting_1214030 | chr5_7820347_+ | SINE | Alu | Name=AluJb |
| ADediting_1214059 | chr5_7829828_+ | SINE | Alu | Name=AluJo |
| ADediting_1214060 | chr5_7829862_+ | SINE | Alu | Name=AluJo |
| ADediting_1214061 | chr5_7829863_+ | SINE | Alu | Name=AluJo |
| ADediting_1214062 | chr5_7829959_+ | SINE | Alu | Name=AluJo |
| ADediting_1657825 | chr5_7417305_+ | LINE | L1 | Name=L1M5 |
| ADediting_1657826 | chr5_7417309_+ | LINE | L1 | Name=L1M5 |
| ADediting_1657827 | chr5_7417310_+ | LINE | L1 | Name=L1M5 |
| ADediting_1657828 | chr5_7417318_+ | LINE | L1 | Name=L1M5 |
| ADediting_1657829 | chr5_7417338_+ | LINE | L1 | Name=L1M5 |
| ADediting_1657830 | chr5_7417369_+ | LINE | L1 | Name=L1M5 |
| ADediting_1657831 | chr5_7423398_+ | LTR | ERVL-MaLR | Name=THE1B |
| ADediting_1657838 | chr5_7480133_+ | LINE | L1 | Name=L1PA13 |
| ADediting_1657839 | chr5_7480354_+ | LINE | L1 | Name=L1PA13 |
| ADediting_1657840 | chr5_7480378_+ | LINE | L1 | Name=L1PA13 |
| ADediting_1657841 | chr5_7480379_+ | LINE | L1 | Name=L1PA13 |
| ADediting_1657842 | chr5_7480387_+ | LINE | L1 | Name=L1PA13 |
| ADediting_1657843 | chr5_7480392_+ | LINE | L1 | Name=L1PA13 |
| ADediting_1657844 | chr5_7480410_+ | LINE | L1 | Name=L1PA13 |
| ADediting_1657845 | chr5_7481003_+ | LINE | L1 | Name=L1MA3 |
| ADediting_1657846 | chr5_7481027_+ | LINE | L1 | Name=L1MA3 |
| ADediting_1657928 | chr5_7631053_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1657929 | chr5_7631065_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1657930 | chr5_7668199_+ | LTR | ERVL | Name=MLT2D |
| ADediting_1657931 | chr5_7668222_+ | LTR | ERVL | Name=MLT2D |
Top |
RNA A-to-I editing events in the alternative splicing sites for ADCY2 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for ADCY2 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
 | |
 | |
 | |
 | |
 | |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for ADCY2 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for ADCY2 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1214060 | chr5_7829862_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-4437 | chr5 | 7829860 | 7829867 | 8mer-1a | 7829847 | 7829867 | 146 | -19.6 |
| ADediting_1214062 | chr5_7829959_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-140-3p | chr5 | 7829954 | 7829960 | 7mer-m8 | 7829941 | 7829961 | 155 | -21.26 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1214059 | chr5_7829828_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-5089-5p | chr5 | 7829821 | 7829828 | 8mer-1a | 7829807 | 7829828 | 149 | -15.71 |
| ADediting_1214059 | chr5_7829828_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-6513-5p | chr5 | 7829822 | 7829828 | 7mer-m8 | 7829805 | 7829829 | 154 | -21.25 |
| ADediting_1214059 | chr5_7829828_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-6728-5p | chr5 | 7829822 | 7829828 | 7mer-1a | 7829805 | 7829828 | 140 | -23.78 |
| ADediting_1214060 | chr5_7829862_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-27a-5p | chr5 | 7829860 | 7829867 | 8mer-1a | 7829846 | 7829867 | 153 | -14.08 |
| ADediting_1214060 | chr5_7829862_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-4720-3p | chr5 | 7829858 | 7829864 | 7mer-m8 | 7829845 | 7829865 | 150 | -11.62 |
| ADediting_1214061 | chr5_7829863_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-27a-5p | chr5 | 7829860 | 7829867 | 8mer-1a | 7829846 | 7829867 | 153 | -14.08 |
| ADediting_1214061 | chr5_7829863_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-4720-3p | chr5 | 7829858 | 7829864 | 7mer-m8 | 7829845 | 7829865 | 150 | -11.62 |
| ADediting_1214062 | chr5_7829959_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-7151-3p | chr5 | 7829952 | 7829958 | 7mer-m8 | 7829939 | 7829959 | 140 | -17.86 |
| ADediting_1214062 | chr5_7829959_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-8052 | chr5 | 7829958 | 7829964 | 7mer-1a | 7829944 | 7829964 | 141 | -25.19 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-589-3p | chr5 | 7829762 | 7829768 | 7mer-m8 | 7829746 | 7829769 | 154 | -15.39 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-151a-3p | chr5 | 7829627 | 7829633 | 7mer-m8 | 7829614 | 7829634 | 149 | -19.71 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-337-3p | chr5 | 7829598 | 7829605 | 8mer-1a | 7829584 | 7829605 | 148 | -11.34 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-381-3p | chr5 | 7827541 | 7827547 | 7mer-m8 | 7827527 | 7827548 | 143 | -12 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-641 | chr5 | 7827389 | 7827395 | 7mer-1a | 7827370 | 7827395 | 151 | -22.09 |
| ADediting_1596844 | chr1_162342605_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-556-3p | chr5 | 7827165 | 7827172 | 8mer-1a | 7827151 | 7827172 | 149 | -9.23 |
| ADediting_496066 | chr15_66496985_- | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-4512 | chr5 | 7829168 | 7829175 | 8mer-1a | 7829155 | 7829175 | 145 | -15.97 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-5585-3p | chr5 | 7829746 | 7829752 | 7mer-m8 | 7829731 | 7829753 | 151 | -15.47 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-5688 | chr5 | 7827596 | 7827602 | 7mer-m8 | 7827585 | 7827603 | 143 | -9.57 |
| ADediting_1337758 | chr7_5495892_- | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-589-5p | chr5 | 7829245 | 7829251 | 7mer-m8 | 7829232 | 7829252 | 147 | -14.97 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-4477b | chr5 | 7829444 | 7829451 | 8mer-1a | 7829430 | 7829451 | 154 | -9.58 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-4477b | chr5 | 7829580 | 7829586 | 7mer-m8 | 7829563 | 7829587 | 152 | -10.53 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-4477b | chr5 | 7829444 | 7829451 | 8mer-1a | 7829430 | 7829451 | 154 | -9.58 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-4477b | chr5 | 7829580 | 7829586 | 7mer-m8 | 7829563 | 7829587 | 152 | -10.53 |
| ADediting_286380 | chr11_79422188_- | ENSG00000078295.17 | ENST00000338316.9 | ADCY2-201 | hsa-miR-5579-3p | chr5 | 7828161 | 7828168 | 8mer-1a | 7828147 | 7828168 | 140 | -10.66 |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for ADCY2 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000338316.9 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1214059 | ENST00000338316.9 | chr5_7829828_+ | 6392 | -2184.90 | -2185.20 | -2187.20 |
| ADediting_1214060 | ENST00000338316.9 | chr5_7829862_+ | 6426 | -2185.20 | -2185.20 | -2187.20 |
| ADediting_1214061 | ENST00000338316.9 | chr5_7829863_+ | 6427 | -2187.80 | -2185.20 | -2187.20 |
| ADediting_1214062 | ENST00000338316.9 | chr5_7829959_+ | 6523 | -2184.90 | -2185.20 | -2187.20 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for ADCY2 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| TCX | ADediting_1213951 | chr5_7798719_+ | 0.241023644403899 | 0.096311647260108 | 0.849360139610123 | -0.0156379909853229 | 6.71854860573936e-06 | 0.358335245188947 |
| DLPFC | ADediting_1213954 | chr5_7798746_+ | 0.221826476397625 | 0.0695840588421492 | 0.933355059984582 | 0.00476878497301421 | 6.06638624055204e-08 | 0.301676921324172 |
| TCX | ADediting_1213959 | chr5_7798841_+ | 0.0761799490203428 | 0.14523513815118 | 0.816038127454865 | 0.0191537621075264 | 2.75063494894037e-06 | 0.372098624200309 |
| DLPFC | ADediting_1213962 | chr5_7800402_+ | 6.46196674802602e-05 | 0.22491091297848 | 0.0339133288479774 | 0.120517856565138 | 2.48807223714788e-08 | 0.31000678199451 |
| TCX | ADediting_1213962 | chr5_7800402_+ | 0.205799732294925 | 0.103892444359759 | 0.769901632810509 | -0.024080799305065 | 3.58033492862887e-06 | 0.368101282104421 |
| DLPFC | ADediting_1213965 | chr5_7800430_+ | 0.0205313945654751 | 0.131527205839405 | 0.74544733990203 | 0.0185119826662856 | 1.71675973062921e-10 | 0.352357068507266 |
| DLPFC | ADediting_1213968 | chr5_7800505_+ | 0.0783392318454534 | 0.100137340134979 | 0.595809409831774 | -0.0302420403955327 | 4.31060460616893e-14 | 0.411404783019424 |
| DLPFC | ADediting_1213971 | chr5_7800515_+ | 0.418414881460776 | 0.0461198661764268 | 0.243464627567697 | -0.0664405826412225 | 1.41673825469386e-08 | 0.315139780212862 |
| DLPFC | ADediting_1213972 | chr5_7800541_+ | 0.049086148867167 | 0.111866820724738 | 0.914327771840236 | 0.00613493768707622 | 5.66314407589935e-08 | 0.302329150727479 |
| DLPFC | ADediting_1213973 | chr5_7800542_+ | 0.148590955317873 | 0.0822367790208119 | 0.442933001893524 | -0.0437326776890045 | 4.22604947345182e-11 | 0.363219253923865 |
| DLPFC | ADediting_1213978 | chr5_7800611_+ | 0.000203177400397746 | 0.209499816599356 | 0.0980810989535418 | 0.0941254131971881 | 3.58898807179221e-09 | 0.327263218289851 |
| TCX | ADediting_1213978 | chr5_7800611_+ | 0.0915227926126375 | 0.1382712784692 | 0.709093537091895 | -0.0307110709526734 | 7.32713303678354e-08 | 0.422311477009241 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 5.59129456170193e-26 | 0.550677567172147 | 2.51244553425141e-17 | 0.456027589545237 | 9.35241677199402e-06 | 0.248737472324569 |
| AC | 1.29939552533287e-33 | 0.667517474600969 | 2.36710688234369e-16 | 0.487835118865937 | 4.5815432507542e-39 | 0.706218000454055 |
| PCC | 5.83604100563148e-12 | 0.47144093366972 | 3.17190561501093e-08 | 0.387085098218006 | 1.78438705211919e-10 | 0.440616308854216 |
| CER | 0.000697471270720765 | 0.273819218335499 | 0.0277314410256227 | 0.179753444857414 | 9.7850395739147e-23 | 0.692426455525367 |
| TCX | 5.3631721047711e-09 | 0.45402916728712 | 0.101663263827058 | 0.134165081715048 | 1.9772365410627e-08 | 0.438607188766163 |
| FP | 1.68624918101601e-21 | 0.635203178541373 | 2.83065072794108e-13 | 0.511856884271871 | 3.14400680322712e-13 | 0.511008625470838 |
| IFG | 1.62984138117728e-06 | 0.799527024654412 | 1.69454737391622e-05 | 0.748339104707505 | 0.132481564313032 | 0.309278553129248 |
| PG | 6.1359096173667e-14 | 0.514104829013604 | 3.48101233570515e-09 | 0.416131540526006 | 4.39921538269098e-06 | 0.329444644357647 |
| STG | 1.19366995624781e-09 | 0.603886550219196 | 7.7739533011542e-06 | 0.466379144311522 | 7.78026042288567e-05 | 0.417491844325833 |
Top |
Relation with AD stages for ADCY2 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 1.17427937199617e-05 | 0.407939667926288 |
| TCX | 1.86574351467898e-09 | 0.542664636997643 |
Top |
RelatedDrugs for ADCY2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| ADCY2 | Q08462 | DB09121 | Aurothioglucose | Adenylate cyclase type 2 | small molecule | approved|withdrawn |
Top |
RelatedDiseases for ADCY2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| ADCY2 | C0004096 | Asthma | 1 | CTD_human |
| ADCY2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|