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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for WDR4 |
 Gene summary |
| Gene information | Gene symbol | WDR4 | Gene ID | 10785 |
| Gene name | WD repeat domain 4 | |
| Synonyms | GAMOS6|MIGSB|TRM82|TRMT82|hWH | |
| Cytomap | 21q22.3 | |
| Type of gene | protein-coding | |
| Description | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4TRM82 tRNA methyltransferase 82 homologWD repeat-containing protein 4protein Wuho homologtRNA (guanine-N(7)-)-methyltransferase subunit WDR4 | |
| Modification date | 20200320 | |
| UniProtAcc | P57081, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| WDR4 | GO:0006400 | tRNA modification | 15861136 |
Top |
RNA A-to-I events for WDR4 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_961240(42843463, -), ADediting_961241(42843468, -), ADediting_961242(42843471, -), ADediting_961243(42843483, -), ADediting_961244(42843484, -), ADediting_961245(42843508, -), ADediting_961246(42843513, -), ADediting_961247(42843519, -), ADediting_961248(42843526, -), ADediting_961249(42843532, -), ADediting_961250(42843543, -), ADediting_961251(42843549, -), ADediting_961252(42843557, -), ADediting_961253(42843559, -), ADediting_961254(42843575, -), ADediting_961255(42843584, -), ADediting_961256(42843603, -), ADediting_961257(42843604, -), ADediting_961258(42843609, -), ADediting_961259(42843621, -), ADediting_961260(42843631, -), ADediting_961261(42843646, -), ADediting_961262(42843670, -), ADediting_961263(42843671, -), ADediting_961264(42843679, -), ADediting_961265(42843680, -), ADediting_961266(42843682, -), ADediting_961267(42843685, -), ADediting_961268(42843688, -), ADediting_961269(42843689, -), ADediting_961270(42843690, -), ADediting_961271(42843695, -), ADediting_961272(42843697, -), ADediting_961273(42843702, -), ADediting_961274(42843730, -), ADediting_961275(42843733, -), ADediting_961276(42843734, -), ADediting_961277(42843744, -), ADediting_961278(42843745, -), ADediting_961279(42843746, -), ADediting_961280(42843749, -), ADediting_961281(42843760, -), ADediting_961282(42843761, -), ADediting_961283(42843768, -), ADediting_961284(42843770, -), ADediting_961285(42843799, -), ADediting_961286(42843831, -), ADediting_961287(42843832, -), ADediting_961288(42843840, -), ADediting_961289(42843854, -), ADediting_961290(42843890, -), ADediting_961291(42843909, -), ADediting_961292(42843918, -), ADediting_961293(42843923, -), ADediting_961294(42843937, -), ADediting_961295(42843946, -), ADediting_961296(42843947, -), ADediting_961297(42843955, -), ADediting_961298(42843957, -), ADediting_961299(42843958, -), ADediting_961300(42843970, -), ADediting_961301(42843972, -), ADediting_961302(42843985, -), ADediting_961303(42845003, -), ADediting_961304(42845876, -), ADediting_961305(42845885, -), ADediting_961306(42845888, -), ADediting_961307(42845889, -), ADediting_961308(42845890, -), ADediting_961309(42845898, -), ADediting_961310(42845912, -), ADediting_961311(42845915, -), ADediting_961312(42845916, -), ADediting_961313(42845941, -), ADediting_961314(42845967, -), ADediting_961315(42845985, -), ADediting_961316(42846020, -), ADediting_961317(42846023, -), ADediting_961318(42846032, -), ADediting_961319(42846037, -), ADediting_961320(42846049, -), ADediting_961321(42846050, -), ADediting_961322(42846092, -), ADediting_961323(42846099, -), ADediting_961324(42846125, -), ADediting_961325(42846131, -), ADediting_961326(42846585, -), ADediting_961327(42846605, -), ADediting_961328(42846618, -), ADediting_961329(42846627, -), ADediting_961330(42846630, -), ADediting_961331(42846631, -), ADediting_961332(42846637, -), ADediting_961333(42846644, -), ADediting_961334(42846645, -), ADediting_961335(42846651, -), ADediting_961336(42846654, -), ADediting_961337(42846656, -), ADediting_961338(42846661, -), ADediting_961339(42846691, -), ADediting_961340(42846699, -), ADediting_961341(42846765, -), ADediting_961342(42846777, -), ADediting_961343(42846778, -), ADediting_961344(42846805, -), ADediting_961345(42846817, -), ADediting_961346(42846830, -), ADediting_961347(42846839, -), ADediting_961348(42846856, -), ADediting_961349(42846859, -), ADediting_961350(42846873, -), ADediting_961351(42846874, -), ADediting_961352(42846898, -), ADediting_961353(42846900, -), ADediting_961354(42846921, -), ADediting_961355(42846926, -), ADediting_961356(42846934, -), ADediting_961357(42846938, -), ADediting_961358(42846939, -), ADediting_961359(42846958, -), ADediting_961360(42846991, -), ADediting_961361(42846992, -), ADediting_961362(42846994, -), ADediting_961363(42867291, -), ADediting_961364(42870737, -), ADediting_961365(42872047, -), ADediting_961366(42872061, -), ADediting_961367(42872123, -), ADediting_961368(42872149, -), ADediting_961369(42872261, -), ADediting_961370(42872278, -), ADediting_961371(42872825, -), ADediting_961372(42872855, -), ADediting_961373(42875384, -), ADediting_961374(42875472, -), ADediting_961375(42876351, -), ADediting_961376(42876352, -), ADediting_961377(42876417, -), ADediting_961378(42877206, -), ADediting_961379(42877236, -), ADediting_961380(42877281, -), ADediting_961381(42877308, -), ADediting_961382(42877347, -), ADediting_961383(42877348, -), ADediting_961384(42877855, -), ADediting_961385(42877933, -), ADediting_1569025(42843895, -), ADediting_1569026(42847012, -), ADediting_1641985(42872057, -), ADediting_1641986(42872744, -), |
Top |
RNA editing positional annotations for WDR4 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_961240 | chr21_42843463_- | intronic |
| ADediting_961241 | chr21_42843468_- | intronic |
| ADediting_961242 | chr21_42843471_- | intronic |
| ADediting_961243 | chr21_42843483_- | intronic |
| ADediting_961244 | chr21_42843484_- | intronic |
| ADediting_961245 | chr21_42843508_- | intronic |
| ADediting_961246 | chr21_42843513_- | intronic |
| ADediting_961247 | chr21_42843519_- | intronic |
| ADediting_961248 | chr21_42843526_- | intronic |
| ADediting_961249 | chr21_42843532_- | intronic |
| ADediting_961250 | chr21_42843543_- | intronic |
| ADediting_961251 | chr21_42843549_- | intronic |
| ADediting_961252 | chr21_42843557_- | intronic |
| ADediting_961253 | chr21_42843559_- | intronic |
| ADediting_961254 | chr21_42843575_- | intronic |
| ADediting_961255 | chr21_42843584_- | intronic |
| ADediting_961256 | chr21_42843603_- | intronic |
| ADediting_961257 | chr21_42843604_- | intronic |
| ADediting_961258 | chr21_42843609_- | intronic |
| ADediting_961259 | chr21_42843621_- | intronic |
| ADediting_961260 | chr21_42843631_- | intronic |
| ADediting_961261 | chr21_42843646_- | intronic |
| ADediting_961262 | chr21_42843670_- | intronic |
| ADediting_961263 | chr21_42843671_- | intronic |
| ADediting_961264 | chr21_42843679_- | intronic |
| ADediting_961265 | chr21_42843680_- | intronic |
| ADediting_961266 | chr21_42843682_- | intronic |
| ADediting_961267 | chr21_42843685_- | intronic |
| ADediting_961268 | chr21_42843688_- | intronic |
| ADediting_961269 | chr21_42843689_- | intronic |
| ADediting_961270 | chr21_42843690_- | intronic |
| ADediting_961271 | chr21_42843695_- | intronic |
| ADediting_961272 | chr21_42843697_- | intronic |
| ADediting_961273 | chr21_42843702_- | intronic |
| ADediting_961274 | chr21_42843730_- | intronic |
| ADediting_961275 | chr21_42843733_- | intronic |
| ADediting_961276 | chr21_42843734_- | intronic |
| ADediting_961277 | chr21_42843744_- | intronic |
| ADediting_961278 | chr21_42843745_- | intronic |
| ADediting_961279 | chr21_42843746_- | intronic |
| ADediting_961280 | chr21_42843749_- | intronic |
| ADediting_961281 | chr21_42843760_- | intronic |
| ADediting_961282 | chr21_42843761_- | intronic |
| ADediting_961283 | chr21_42843768_- | intronic |
| ADediting_961284 | chr21_42843770_- | intronic |
| ADediting_961285 | chr21_42843799_- | intronic |
| ADediting_961286 | chr21_42843831_- | intronic |
| ADediting_961287 | chr21_42843832_- | intronic |
| ADediting_961288 | chr21_42843840_- | intronic |
| ADediting_961289 | chr21_42843854_- | intronic |
| ADediting_961290 | chr21_42843890_- | intronic |
| ADediting_961291 | chr21_42843909_- | intronic |
| ADediting_961292 | chr21_42843918_- | intronic |
| ADediting_961293 | chr21_42843923_- | intronic |
| ADediting_961294 | chr21_42843937_- | intronic |
| ADediting_961295 | chr21_42843946_- | intronic |
| ADediting_961296 | chr21_42843947_- | intronic |
| ADediting_961297 | chr21_42843955_- | intronic |
| ADediting_961298 | chr21_42843957_- | intronic |
| ADediting_961299 | chr21_42843958_- | intronic |
| ADediting_961300 | chr21_42843970_- | intronic |
| ADediting_961301 | chr21_42843972_- | intronic |
| ADediting_961302 | chr21_42843985_- | intronic |
| ADediting_961303 | chr21_42845003_- | intronic |
| ADediting_961304 | chr21_42845876_- | intronic |
| ADediting_961305 | chr21_42845885_- | intronic |
| ADediting_961306 | chr21_42845888_- | intronic |
| ADediting_961307 | chr21_42845889_- | intronic |
| ADediting_961308 | chr21_42845890_- | intronic |
| ADediting_961309 | chr21_42845898_- | intronic |
| ADediting_961310 | chr21_42845912_- | intronic |
| ADediting_961311 | chr21_42845915_- | intronic |
| ADediting_961312 | chr21_42845916_- | intronic |
| ADediting_961313 | chr21_42845941_- | intronic |
| ADediting_961314 | chr21_42845967_- | intronic |
| ADediting_961315 | chr21_42845985_- | intronic |
| ADediting_961316 | chr21_42846020_- | intronic |
| ADediting_961317 | chr21_42846023_- | intronic |
| ADediting_961318 | chr21_42846032_- | intronic |
| ADediting_961319 | chr21_42846037_- | intronic |
| ADediting_961320 | chr21_42846049_- | intronic |
| ADediting_961321 | chr21_42846050_- | intronic |
| ADediting_961322 | chr21_42846092_- | intronic |
| ADediting_961323 | chr21_42846099_- | intronic |
| ADediting_961324 | chr21_42846125_- | intronic |
| ADediting_961325 | chr21_42846131_- | intronic |
| ADediting_961326 | chr21_42846585_- | intronic |
| ADediting_961327 | chr21_42846605_- | intronic |
| ADediting_961328 | chr21_42846618_- | intronic |
| ADediting_961329 | chr21_42846627_- | intronic |
| ADediting_961330 | chr21_42846630_- | intronic |
| ADediting_961331 | chr21_42846631_- | intronic |
| ADediting_961332 | chr21_42846637_- | intronic |
| ADediting_961333 | chr21_42846644_- | intronic |
| ADediting_961334 | chr21_42846645_- | intronic |
| ADediting_961335 | chr21_42846651_- | intronic |
| ADediting_961336 | chr21_42846654_- | intronic |
| ADediting_961337 | chr21_42846656_- | intronic |
| ADediting_961338 | chr21_42846661_- | intronic |
| ADediting_961339 | chr21_42846691_- | intronic |
| ADediting_961340 | chr21_42846699_- | intronic |
| ADediting_961341 | chr21_42846765_- | intronic |
| ADediting_961342 | chr21_42846777_- | intronic |
| ADediting_961343 | chr21_42846778_- | intronic |
| ADediting_961344 | chr21_42846805_- | intronic |
| ADediting_961345 | chr21_42846817_- | intronic |
| ADediting_961346 | chr21_42846830_- | intronic |
| ADediting_961347 | chr21_42846839_- | intronic |
| ADediting_961348 | chr21_42846856_- | intronic |
| ADediting_961349 | chr21_42846859_- | intronic |
| ADediting_961350 | chr21_42846873_- | intronic |
| ADediting_961351 | chr21_42846874_- | intronic |
| ADediting_961352 | chr21_42846898_- | intronic |
| ADediting_961353 | chr21_42846900_- | intronic |
| ADediting_961354 | chr21_42846921_- | intronic |
| ADediting_961355 | chr21_42846926_- | intronic |
| ADediting_961356 | chr21_42846934_- | intronic |
| ADediting_961357 | chr21_42846938_- | intronic |
| ADediting_961358 | chr21_42846939_- | intronic |
| ADediting_961359 | chr21_42846958_- | intronic |
| ADediting_961360 | chr21_42846991_- | intronic |
| ADediting_961361 | chr21_42846992_- | intronic |
| ADediting_961362 | chr21_42846994_- | intronic |
| ADediting_961363 | chr21_42867291_- | intronic |
| ADediting_961364 | chr21_42870737_- | intronic |
| ADediting_961365 | chr21_42872047_- | intronic |
| ADediting_961366 | chr21_42872061_- | intronic |
| ADediting_961367 | chr21_42872123_- | intronic |
| ADediting_961368 | chr21_42872149_- | intronic |
| ADediting_961369 | chr21_42872261_- | intronic |
| ADediting_961370 | chr21_42872278_- | intronic |
| ADediting_961371 | chr21_42872825_- | intronic |
| ADediting_961372 | chr21_42872855_- | intronic |
| ADediting_961373 | chr21_42875384_- | intronic |
| ADediting_961374 | chr21_42875472_- | intronic |
| ADediting_961375 | chr21_42876351_- | intronic |
| ADediting_961376 | chr21_42876352_- | intronic |
| ADediting_961377 | chr21_42876417_- | intronic |
| ADediting_961378 | chr21_42877206_- | intronic |
| ADediting_961379 | chr21_42877236_- | intronic |
| ADediting_961380 | chr21_42877281_- | intronic |
| ADediting_961381 | chr21_42877308_- | intronic |
| ADediting_961382 | chr21_42877347_- | intronic |
| ADediting_961383 | chr21_42877348_- | intronic |
| ADediting_961384 | chr21_42877855_- | intronic |
| ADediting_961385 | chr21_42877933_- | intronic |
| ADediting_1569025 | chr21_42843895_- | intronic |
| ADediting_1569026 | chr21_42847012_- | intronic |
| ADediting_1641985 | chr21_42872057_- | intronic |
| ADediting_1641986 | chr21_42872744_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_961240 | chr21_42843463_- | SINE | Alu | Name=AluJr |
| ADediting_961241 | chr21_42843468_- | SINE | Alu | Name=AluJr |
| ADediting_961242 | chr21_42843471_- | SINE | Alu | Name=AluJr |
| ADediting_961243 | chr21_42843483_- | SINE | Alu | Name=AluJr |
| ADediting_961244 | chr21_42843484_- | SINE | Alu | Name=AluJr |
| ADediting_961245 | chr21_42843508_- | SINE | Alu | Name=AluJr |
| ADediting_961246 | chr21_42843513_- | SINE | Alu | Name=AluJr |
| ADediting_961247 | chr21_42843519_- | SINE | Alu | Name=AluJr |
| ADediting_961248 | chr21_42843526_- | SINE | Alu | Name=AluJr |
| ADediting_961249 | chr21_42843532_- | SINE | Alu | Name=AluJr |
| ADediting_961250 | chr21_42843543_- | SINE | Alu | Name=AluJr |
| ADediting_961251 | chr21_42843549_- | SINE | Alu | Name=AluJr |
| ADediting_961252 | chr21_42843557_- | SINE | Alu | Name=AluJr |
| ADediting_961253 | chr21_42843559_- | SINE | Alu | Name=AluJr |
| ADediting_961254 | chr21_42843575_- | SINE | Alu | Name=AluJr |
| ADediting_961255 | chr21_42843584_- | SINE | Alu | Name=AluSx3 |
| ADediting_961256 | chr21_42843603_- | SINE | Alu | Name=AluSx3 |
| ADediting_961257 | chr21_42843604_- | SINE | Alu | Name=AluSx3 |
| ADediting_961258 | chr21_42843609_- | SINE | Alu | Name=AluSx3 |
| ADediting_961259 | chr21_42843621_- | SINE | Alu | Name=AluSx3 |
| ADediting_961260 | chr21_42843631_- | SINE | Alu | Name=AluSx3 |
| ADediting_961261 | chr21_42843646_- | SINE | Alu | Name=AluSx3 |
| ADediting_961262 | chr21_42843670_- | SINE | Alu | Name=AluSx3 |
| ADediting_961263 | chr21_42843671_- | SINE | Alu | Name=AluSx3 |
| ADediting_961264 | chr21_42843679_- | SINE | Alu | Name=AluSx3 |
| ADediting_961265 | chr21_42843680_- | SINE | Alu | Name=AluSx3 |
| ADediting_961266 | chr21_42843682_- | SINE | Alu | Name=AluSx3 |
| ADediting_961267 | chr21_42843685_- | SINE | Alu | Name=AluSx3 |
| ADediting_961268 | chr21_42843688_- | SINE | Alu | Name=AluSx3 |
| ADediting_961269 | chr21_42843689_- | SINE | Alu | Name=AluSx3 |
| ADediting_961270 | chr21_42843690_- | SINE | Alu | Name=AluSx3 |
| ADediting_961271 | chr21_42843695_- | SINE | Alu | Name=AluSx3 |
| ADediting_961272 | chr21_42843697_- | SINE | Alu | Name=AluSx3 |
| ADediting_961273 | chr21_42843702_- | SINE | Alu | Name=AluSx3 |
| ADediting_961274 | chr21_42843730_- | SINE | Alu | Name=AluSx3 |
| ADediting_961275 | chr21_42843733_- | SINE | Alu | Name=AluSx3 |
| ADediting_961276 | chr21_42843734_- | SINE | Alu | Name=AluSx3 |
| ADediting_961277 | chr21_42843744_- | SINE | Alu | Name=AluSx3 |
| ADediting_961278 | chr21_42843745_- | SINE | Alu | Name=AluSx3 |
| ADediting_961279 | chr21_42843746_- | SINE | Alu | Name=AluSx3 |
| ADediting_961280 | chr21_42843749_- | SINE | Alu | Name=AluSx3 |
| ADediting_961281 | chr21_42843760_- | SINE | Alu | Name=AluSx3 |
| ADediting_961282 | chr21_42843761_- | SINE | Alu | Name=AluSx3 |
| ADediting_961283 | chr21_42843768_- | SINE | Alu | Name=AluSx3 |
| ADediting_961284 | chr21_42843770_- | SINE | Alu | Name=AluSx3 |
| ADediting_961285 | chr21_42843799_- | SINE | Alu | Name=AluSx3 |
| ADediting_961286 | chr21_42843831_- | SINE | Alu | Name=AluSx3 |
| ADediting_961287 | chr21_42843832_- | SINE | Alu | Name=AluSx3 |
| ADediting_961288 | chr21_42843840_- | SINE | Alu | Name=AluSx3 |
| ADediting_961289 | chr21_42843854_- | SINE | Alu | Name=AluSx3 |
| ADediting_961290 | chr21_42843890_- | SINE | Alu | Name=AluJr |
| ADediting_961291 | chr21_42843909_- | SINE | Alu | Name=AluJr |
| ADediting_961292 | chr21_42843918_- | SINE | Alu | Name=AluJr |
| ADediting_961293 | chr21_42843923_- | SINE | Alu | Name=AluJr |
| ADediting_961294 | chr21_42843937_- | SINE | Alu | Name=AluJr |
| ADediting_961295 | chr21_42843946_- | SINE | Alu | Name=AluJr |
| ADediting_961296 | chr21_42843947_- | SINE | Alu | Name=AluJr |
| ADediting_961297 | chr21_42843955_- | SINE | Alu | Name=AluJr |
| ADediting_961298 | chr21_42843957_- | SINE | Alu | Name=AluJr |
| ADediting_961299 | chr21_42843958_- | SINE | Alu | Name=AluJr |
| ADediting_961300 | chr21_42843970_- | SINE | Alu | Name=AluJr |
| ADediting_961301 | chr21_42843972_- | SINE | Alu | Name=AluJr |
| ADediting_961302 | chr21_42843985_- | LINE | L1 | Name=L1ME3A |
| ADediting_961303 | chr21_42845003_- | LTR | ERVL | Name=LTR41 |
| ADediting_961304 | chr21_42845876_- | SINE | Alu | Name=AluJr |
| ADediting_961305 | chr21_42845885_- | SINE | Alu | Name=AluJr |
| ADediting_961306 | chr21_42845888_- | SINE | Alu | Name=AluJr |
| ADediting_961307 | chr21_42845889_- | SINE | Alu | Name=AluJr |
| ADediting_961308 | chr21_42845890_- | SINE | Alu | Name=AluJr |
| ADediting_961309 | chr21_42845898_- | SINE | Alu | Name=AluJr |
| ADediting_961310 | chr21_42845912_- | SINE | Alu | Name=AluJr |
| ADediting_961311 | chr21_42845915_- | SINE | Alu | Name=AluJr |
| ADediting_961312 | chr21_42845916_- | SINE | Alu | Name=AluJr |
| ADediting_961313 | chr21_42845941_- | SINE | Alu | Name=AluJr |
| ADediting_961314 | chr21_42845967_- | SINE | Alu | Name=AluJr |
| ADediting_961315 | chr21_42845985_- | SINE | Alu | Name=AluJr |
| ADediting_961316 | chr21_42846020_- | SINE | Alu | Name=AluJr |
| ADediting_961317 | chr21_42846023_- | SINE | Alu | Name=AluJr |
| ADediting_961318 | chr21_42846032_- | SINE | Alu | Name=AluJr |
| ADediting_961319 | chr21_42846037_- | SINE | Alu | Name=AluJr |
| ADediting_961320 | chr21_42846049_- | SINE | Alu | Name=AluJr |
| ADediting_961321 | chr21_42846050_- | SINE | Alu | Name=AluJr |
| ADediting_961322 | chr21_42846092_- | SINE | Alu | Name=AluJr |
| ADediting_961323 | chr21_42846099_- | SINE | Alu | Name=AluJr |
| ADediting_961324 | chr21_42846125_- | SINE | Alu | Name=AluJr |
| ADediting_961325 | chr21_42846131_- | SINE | Alu | Name=AluJr |
| ADediting_961326 | chr21_42846585_- | SINE | Alu | Name=AluJb |
| ADediting_961327 | chr21_42846605_- | SINE | Alu | Name=AluJb |
| ADediting_961328 | chr21_42846618_- | SINE | Alu | Name=AluJb |
| ADediting_961329 | chr21_42846627_- | SINE | Alu | Name=AluJb |
| ADediting_961330 | chr21_42846630_- | SINE | Alu | Name=AluJb |
| ADediting_961331 | chr21_42846631_- | SINE | Alu | Name=AluJb |
| ADediting_961332 | chr21_42846637_- | SINE | Alu | Name=AluJb |
| ADediting_961333 | chr21_42846644_- | SINE | Alu | Name=AluJb |
| ADediting_961334 | chr21_42846645_- | SINE | Alu | Name=AluJb |
| ADediting_961335 | chr21_42846651_- | SINE | Alu | Name=AluJb |
| ADediting_961336 | chr21_42846654_- | SINE | Alu | Name=AluJb |
| ADediting_961337 | chr21_42846656_- | SINE | Alu | Name=AluJb |
| ADediting_961338 | chr21_42846661_- | SINE | Alu | Name=AluJb |
| ADediting_961339 | chr21_42846691_- | SINE | Alu | Name=AluJb |
| ADediting_961340 | chr21_42846699_- | SINE | Alu | Name=AluJb |
| ADediting_961341 | chr21_42846765_- | SINE | Alu | Name=AluSx1 |
| ADediting_961342 | chr21_42846777_- | SINE | Alu | Name=AluSx1 |
| ADediting_961343 | chr21_42846778_- | SINE | Alu | Name=AluSx1 |
| ADediting_961344 | chr21_42846805_- | SINE | Alu | Name=AluSx1 |
| ADediting_961345 | chr21_42846817_- | SINE | Alu | Name=AluSx1 |
| ADediting_961346 | chr21_42846830_- | SINE | Alu | Name=AluSx1 |
| ADediting_961347 | chr21_42846839_- | SINE | Alu | Name=AluSx1 |
| ADediting_961348 | chr21_42846856_- | SINE | Alu | Name=AluSx1 |
| ADediting_961349 | chr21_42846859_- | SINE | Alu | Name=AluSx1 |
| ADediting_961350 | chr21_42846873_- | SINE | Alu | Name=AluSx1 |
| ADediting_961351 | chr21_42846874_- | SINE | Alu | Name=AluSx1 |
| ADediting_961352 | chr21_42846898_- | SINE | Alu | Name=AluSx1 |
| ADediting_961353 | chr21_42846900_- | SINE | Alu | Name=AluSx1 |
| ADediting_961354 | chr21_42846921_- | SINE | Alu | Name=AluSx1 |
| ADediting_961355 | chr21_42846926_- | SINE | Alu | Name=AluSx1 |
| ADediting_961356 | chr21_42846934_- | SINE | Alu | Name=AluSx1 |
| ADediting_961357 | chr21_42846938_- | SINE | Alu | Name=AluSx1 |
| ADediting_961358 | chr21_42846939_- | SINE | Alu | Name=AluSx1 |
| ADediting_961359 | chr21_42846958_- | SINE | Alu | Name=AluSx1 |
| ADediting_961360 | chr21_42846991_- | SINE | Alu | Name=AluSx1 |
| ADediting_961361 | chr21_42846992_- | SINE | Alu | Name=AluSx1 |
| ADediting_961362 | chr21_42846994_- | SINE | Alu | Name=AluSx1 |
| ADediting_961363 | chr21_42867291_- | SINE | Alu | Name=AluSx |
| ADediting_961364 | chr21_42870737_- | SINE | Alu | Name=AluSq2 |
| ADediting_961365 | chr21_42872047_- | SINE | Alu | Name=AluSq2 |
| ADediting_961366 | chr21_42872061_- | SINE | Alu | Name=AluSq2 |
| ADediting_961367 | chr21_42872123_- | SINE | Alu | Name=AluSq2 |
| ADediting_961368 | chr21_42872149_- | SINE | Alu | Name=AluSq2 |
| ADediting_961369 | chr21_42872261_- | SINE | Alu | Name=AluSq2 |
| ADediting_961370 | chr21_42872278_- | SINE | Alu | Name=AluSq2 |
| ADediting_961371 | chr21_42872825_- | SINE | Alu | Name=AluSq2 |
| ADediting_961372 | chr21_42872855_- | SINE | Alu | Name=AluSq2 |
| ADediting_961373 | chr21_42875384_- | SINE | Alu | Name=AluSc |
| ADediting_961374 | chr21_42875472_- | SINE | Alu | Name=AluSc |
| ADediting_961375 | chr21_42876351_- | SINE | Alu | Name=AluSx1 |
| ADediting_961376 | chr21_42876352_- | SINE | Alu | Name=AluSx1 |
| ADediting_961377 | chr21_42876417_- | SINE | Alu | Name=AluSx1 |
| ADediting_961378 | chr21_42877206_- | SINE | Alu | Name=AluSx1 |
| ADediting_961379 | chr21_42877236_- | SINE | Alu | Name=AluSx1 |
| ADediting_961380 | chr21_42877281_- | SINE | Alu | Name=AluSx1 |
| ADediting_961381 | chr21_42877308_- | SINE | Alu | Name=AluSx1 |
| ADediting_961382 | chr21_42877347_- | SINE | Alu | Name=AluSx1 |
| ADediting_961383 | chr21_42877348_- | SINE | Alu | Name=AluSx1 |
| ADediting_961384 | chr21_42877855_- | SINE | Alu | Name=AluY |
| ADediting_961385 | chr21_42877933_- | SINE | Alu | Name=AluY |
| ADediting_1569025 | chr21_42843895_- | SINE | Alu | Name=AluJr |
| ADediting_1569026 | chr21_42847012_- | SINE | Alu | Name=AluSx1 |
| ADediting_1641985 | chr21_42872057_- | SINE | Alu | Name=AluSq2 |
| ADediting_1641986 | chr21_42872744_- | SINE | Alu | Name=AluSq2 |
Top |
RNA A-to-I editing events in the alternative splicing sites for WDR4 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for WDR4 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
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| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for WDR4 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for WDR4 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for WDR4 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for WDR4 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| TCX | ADediting_961248 | chr21_42843526_- | 0.000164138272590716 | 0.30297824179933 | 1.56016573623071e-06 | 0.380520476419624 | 0.0377215855771584 | -0.169843309486604 |
| DLPFC | ADediting_961289 | chr21_42843854_- | 4.21968695315971e-06 | 0.257886198159633 | 2.36868542770737e-08 | 0.310458900302272 | 0.830275896836141 | 0.0122230565850445 |
| TCX | ADediting_961289 | chr21_42843854_- | 0.000175509331224612 | 0.30169459782684 | 0.00014755444604865 | 0.305007285303664 | 0.315130384341739 | -0.0825688960090715 |
| TCX | ADediting_961294 | chr21_42843937_- | 0.00203252317906352 | 0.250003432715683 | 2.65421255032638e-06 | 0.372635623504029 | 0.740275067669356 | 0.0272892172190304 |
| PCC | ADediting_961295 | chr21_42843946_- | 3.05234744986547e-06 | 0.330350335062805 | 9.5547148936682e-06 | 0.314238189898275 | 0.824971972025815 | -0.016106885435827 |
| TCX | ADediting_961295 | chr21_42843946_- | 0.000327155916203209 | 0.289465779015057 | 6.89795882759443e-06 | 0.357919264587601 | 0.850319513813621 | -0.0155372155263085 |
| DLPFC | ADediting_961306 | chr21_42845888_- | 0.00138574071993051 | 0.18084262405612 | 5.22440197621945e-08 | 0.303091756689156 | 0.715854044315243 | 0.0207557330850924 |
| DLPFC | ADediting_961310 | chr21_42845912_- | 7.12010958216371e-06 | 0.251911780738935 | 6.13708459624913e-11 | 0.360368161445261 | 0.127926084915501 | 0.0866499580564507 |
| TCX | ADediting_961310 | chr21_42845912_- | 0.00129709832988029 | 0.260271701297664 | 1.19060091263491e-05 | 0.34916941198654 | 0.00251198099614614 | -0.24501416394095 |
| TCX | ADediting_961311 | chr21_42845915_- | 0.00289882729062936 | 0.241583042623973 | 1.13013935704576e-05 | 0.350016191115687 | 0.0868938216949121 | -0.140266937552039 |
| TCX | ADediting_961318 | chr21_42846032_- | 0.00010837538488006 | 0.310804144886848 | 1.37293954729638e-05 | 0.346841659007849 | 0.371627361301633 | -0.0734641182782238 |
| TCX | ADediting_961319 | chr21_42846037_- | 0.00502782608780358 | 0.227931116582081 | 2.54889744200482e-05 | 0.336514182034081 | 0.507205012550405 | -0.0545658351015568 |
| TCX | ADediting_961320 | chr21_42846049_- | 0.00389412556929931 | 0.234359935494096 | 3.64071716261903e-06 | 0.367845880999129 | 0.00565313529284907 | -0.224923963936365 |
| DLPFC | ADediting_961321 | chr21_42846050_- | 0.00059680447062627 | 0.193914205608928 | 5.51156771075975e-08 | 0.302585966326049 | 0.193727171752622 | 0.0740118469394065 |
| TCX | ADediting_961321 | chr21_42846050_- | 0.0011672376369058 | 0.262625215674184 | 7.02062502825585e-06 | 0.357640706075522 | 0.196595469952864 | -0.106024691784493 |
| DLPFC | ADediting_961324 | chr21_42846125_- | 7.35911153313167e-08 | 0.299836527063042 | 9.8318537993569e-10 | 0.338227101062952 | 0.00459027138432455 | 0.160589327985688 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 4.49417990908215e-59 | 0.757851065789377 | 6.68614617546953e-57 | 0.748544726974333 | 3.31658508840444e-06 | 0.260587613958833 |
| AC | 1.43255651020415e-62 | 0.821972727680133 | 2.82165968349367e-55 | 0.792903547856406 | 2.91068861320674e-09 | 0.364304828356814 |
| PCC | 5.20969250569617e-30 | 0.704930788433643 | 3.43073989298686e-34 | 0.738538116087518 | 0.0406950976795729 | 0.148242335504215 |
| CER | 3.0502536730724e-27 | 0.739704838937054 | 3.22152909330806e-15 | 0.586261676896166 | 0.259814097399489 | 0.0925820695922168 |
| TCX | 3.76565970732461e-44 | 0.855516010764584 | 3.7464458418324e-17 | 0.617753532355539 | 0.0048663763655528 | 0.228761790699378 |
| FP | 3.25822612676761e-23 | 0.655321994202461 | 9.687063959987e-23 | 0.649916490472872 | 1.45098548733092e-10 | 0.456889279578833 |
| IFG | 1.10848186274503e-05 | 0.758625622581884 | 1.60265620940813e-06 | 0.799849693407084 | 0.0314729960267066 | 0.431012514873839 |
| STG | 5.27723112186235e-08 | 0.551904124491271 | 1.05890631288378e-06 | 0.503366202605109 | 0.0329841457416633 | 0.232930241729802 |
Top |
Relation with AD stages for WDR4 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_961251 | chr21_42843549_- | 0.00119112190255399 | -0.307837579738504 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 0.0001711764079578 | 0.357143309472821 |
Top |
RelatedDrugs for WDR4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for WDR4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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