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Center for Computational Systems Medicine
Soverview

Gene summary

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RNA A-to-I events

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Differntial gene expression between RNA A-to-I edited versus non-edited samples

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Protein coding region RNA A-to-I editings

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The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

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Relation with ADAR

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Relation with AD stages

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Related drugs with this gene

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Related diseases with this gene


Gene summary for SRSF10

check button Gene summary
Gene informationGene symbol

SRSF10

Gene ID

10772

Gene nameserine and arginine rich splicing factor 10
SynonymsFUSIP1|FUSIP2|NSSR|PPP1R149|SFRS13|SFRS13A|SRp38|SRrp40|TASR|TASR1|TASR2
Cytomap

1p36.11

Type of geneprotein-coding
Descriptionserine/arginine-rich splicing factor 1040 kDa SR-repressor proteinFUS interacting protein (serine-arginine rich) 1FUS-interacting protein (serine-arginine rich) 2SR splicing factor 10TLS-associated SR proteinTLS-associated protein TASRTLS-associate
Modification date20200313
UniProtAcc

O75494,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
SRSF10

GO:0000375

RNA splicing, via transesterification reactions

9774382

SRSF10

GO:0000398

mRNA splicing, via spliceosome

9774382

SRSF10

GO:0006376

mRNA splice site selection

9774382

SRSF10

GO:0048024

regulation of mRNA splicing, via spliceosome

26876937

SRSF10

GO:0048025

negative regulation of mRNA splicing, via spliceosome

11684676


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RNA A-to-I events for SRSF10

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
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check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
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check button RNA A-to-I editing events in AD.
ADediting_80642(23972161, -), ADediting_80643(23972164, -), ADediting_80644(23972174, -), ADediting_80645(23972179, -), ADediting_80646(23972191, -), ADediting_80647(23972192, -), ADediting_80648(23972204, -), ADediting_80649(23972205, -), ADediting_80650(23972206, -), ADediting_80651(23972227, -), ADediting_80652(23972241, -), ADediting_80653(23972244, -), ADediting_80654(23972267, -), ADediting_80655(23972283, -), ADediting_80656(23972304, -), ADediting_80657(23972508, -), ADediting_80658(23972581, -), ADediting_80659(23972655, -), ADediting_80660(23972665, -), ADediting_80661(23972853, -), ADediting_80662(23972879, -), ADediting_80663(23972880, -), ADediting_80664(23972953, -), ADediting_80665(23972959, -), ADediting_80666(23973019, -), ADediting_80667(23973422, -), ADediting_80668(23973521, -), ADediting_80669(23973524, -), ADediting_80670(23973594, -), ADediting_80671(23973602, -), ADediting_80672(23973607, -), ADediting_80673(23974021, -), ADediting_80674(23974077, -), ADediting_80675(23974103, -), ADediting_80676(23974130, -), ADediting_80677(23974136, -), ADediting_80678(23974152, -), ADediting_80679(23974159, -), ADediting_80680(23974160, -), ADediting_80681(23974166, -), ADediting_80682(23974170, -), ADediting_80683(23974186, -), ADediting_80684(23974189, -), ADediting_80685(23974244, -), ADediting_80686(23974566, -), ADediting_80687(23974584, -), ADediting_80688(23974594, -), ADediting_80689(23974612, -), ADediting_80690(23974646, -), ADediting_80691(23974649, -), ADediting_80692(23974655, -), ADediting_80693(23974663, -), ADediting_80694(23974666, -), ADediting_80695(23974689, -), ADediting_80696(23974707, -), ADediting_80697(23974717, -), ADediting_80698(23974728, -), ADediting_80699(23974729, -), ADediting_80700(23974760, -), ADediting_80701(23974766, -), ADediting_80702(23974767, -), ADediting_80703(23974772, -), ADediting_80704(23974819, -), ADediting_80705(23974831, -), ADediting_1518140(23972152, -), ADediting_1518141(23972334, -), ADediting_1518142(23972575, -), ADediting_1518143(23972580, -), ADediting_1518144(23972715, -), ADediting_1518145(23973026, -), ADediting_1518146(23973468, -), ADediting_1518147(23974156, -), ADediting_1518148(23974782, -),

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RNA editing positional annotations for SRSF10 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_80642chr1_23972161_-intronic
ADediting_80643chr1_23972164_-intronic
ADediting_80644chr1_23972174_-intronic
ADediting_80645chr1_23972179_-intronic
ADediting_80646chr1_23972191_-intronic
ADediting_80647chr1_23972192_-intronic
ADediting_80648chr1_23972204_-intronic
ADediting_80649chr1_23972205_-intronic
ADediting_80650chr1_23972206_-intronic
ADediting_80651chr1_23972227_-intronic
ADediting_80652chr1_23972241_-intronic
ADediting_80653chr1_23972244_-intronic
ADediting_80654chr1_23972267_-intronic
ADediting_80655chr1_23972283_-intronic
ADediting_80656chr1_23972304_-intronic
ADediting_80657chr1_23972508_-intronic
ADediting_80658chr1_23972581_-intronic
ADediting_80659chr1_23972655_-intronic
ADediting_80660chr1_23972665_-intronic
ADediting_80661chr1_23972853_-intronic
ADediting_80662chr1_23972879_-intronic
ADediting_80663chr1_23972880_-intronic
ADediting_80664chr1_23972953_-intronic
ADediting_80665chr1_23972959_-intronic
ADediting_80666chr1_23973019_-intronic
ADediting_80667chr1_23973422_-intronic
ADediting_80668chr1_23973521_-intronic
ADediting_80669chr1_23973524_-intronic
ADediting_80670chr1_23973594_-intronic
ADediting_80671chr1_23973602_-intronic
ADediting_80672chr1_23973607_-intronic
ADediting_80673chr1_23974021_-intronic
ADediting_80674chr1_23974077_-intronic
ADediting_80675chr1_23974103_-intronic
ADediting_80676chr1_23974130_-intronic
ADediting_80677chr1_23974136_-intronic
ADediting_80678chr1_23974152_-intronic
ADediting_80679chr1_23974159_-intronic
ADediting_80680chr1_23974160_-intronic
ADediting_80681chr1_23974166_-intronic
ADediting_80682chr1_23974170_-intronic
ADediting_80683chr1_23974186_-intronic
ADediting_80684chr1_23974189_-intronic
ADediting_80685chr1_23974244_-intronic
ADediting_80686chr1_23974566_-intronic
ADediting_80687chr1_23974584_-intronic
ADediting_80688chr1_23974594_-intronic
ADediting_80689chr1_23974612_-intronic
ADediting_80690chr1_23974646_-intronic
ADediting_80691chr1_23974649_-intronic
ADediting_80692chr1_23974655_-intronic
ADediting_80693chr1_23974663_-intronic
ADediting_80694chr1_23974666_-intronic
ADediting_80695chr1_23974689_-intronic
ADediting_80696chr1_23974707_-intronic
ADediting_80697chr1_23974717_-intronic
ADediting_80698chr1_23974728_-intronic
ADediting_80699chr1_23974729_-intronic
ADediting_80700chr1_23974760_-intronic
ADediting_80701chr1_23974766_-intronic
ADediting_80702chr1_23974767_-intronic
ADediting_80703chr1_23974772_-intronic
ADediting_80704chr1_23974819_-intronic
ADediting_80705chr1_23974831_-intronic
ADediting_1518140chr1_23972152_-intronic
ADediting_1518141chr1_23972334_-intronic
ADediting_1518142chr1_23972575_-intronic
ADediting_1518143chr1_23972580_-intronic
ADediting_1518144chr1_23972715_-intronic
ADediting_1518145chr1_23973026_-intronic
ADediting_1518146chr1_23973468_-intronic
ADediting_1518147chr1_23974156_-intronic
ADediting_1518148chr1_23974782_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_80642chr1_23972161_-SINEAluName=AluJo
ADediting_80643chr1_23972164_-SINEAluName=AluJo
ADediting_80644chr1_23972174_-SINEAluName=AluJo
ADediting_80645chr1_23972179_-SINEAluName=AluJo
ADediting_80646chr1_23972191_-SINEAluName=AluJo
ADediting_80647chr1_23972192_-SINEAluName=AluJo
ADediting_80648chr1_23972204_-SINEAluName=AluJo
ADediting_80649chr1_23972205_-SINEAluName=AluJo
ADediting_80650chr1_23972206_-SINEAluName=AluJo
ADediting_80651chr1_23972227_-SINEAluName=AluJo
ADediting_80652chr1_23972241_-SINEAluName=AluJo
ADediting_80653chr1_23972244_-SINEAluName=AluJo
ADediting_80654chr1_23972267_-SINEAluName=AluJo
ADediting_80655chr1_23972283_-SINEAluName=AluJo
ADediting_80656chr1_23972304_-SINEAluName=AluJo
ADediting_80657chr1_23972508_-SINEAluName=AluSz
ADediting_80658chr1_23972581_-SINEAluName=AluSz
ADediting_80659chr1_23972655_-SINEAluName=AluSz
ADediting_80660chr1_23972665_-SINEAluName=AluSz
ADediting_80661chr1_23972853_-SINEAluName=AluSp
ADediting_80662chr1_23972879_-SINEAluName=AluSp
ADediting_80663chr1_23972880_-SINEAluName=AluSp
ADediting_80664chr1_23972953_-SINEAluName=AluSp
ADediting_80665chr1_23972959_-SINEAluName=AluSp
ADediting_80666chr1_23973019_-SINEAluName=AluSp
ADediting_80667chr1_23973422_-SINEAluName=AluJo
ADediting_80668chr1_23973521_-SINEAluName=AluJo
ADediting_80669chr1_23973524_-SINEAluName=AluJo
ADediting_80670chr1_23973594_-SINEAluName=AluJo
ADediting_80671chr1_23973602_-SINEAluName=AluJo
ADediting_80672chr1_23973607_-SINEAluName=AluJo
ADediting_80673chr1_23974021_-SINEAluName=AluSx3
ADediting_80674chr1_23974077_-SINEAluName=AluSx3
ADediting_80675chr1_23974103_-SINEAluName=AluSx3
ADediting_80676chr1_23974130_-SINEAluName=AluSx3
ADediting_80677chr1_23974136_-SINEAluName=AluSx3
ADediting_80678chr1_23974152_-SINEAluName=AluSx3
ADediting_80679chr1_23974159_-SINEAluName=AluSx3
ADediting_80680chr1_23974160_-SINEAluName=AluSx3
ADediting_80681chr1_23974166_-SINEAluName=AluSx3
ADediting_80682chr1_23974170_-SINEAluName=AluSx3
ADediting_80683chr1_23974186_-SINEAluName=AluSx3
ADediting_80684chr1_23974189_-SINEAluName=AluSx3
ADediting_80685chr1_23974244_-SINEAluName=AluSx3
ADediting_80686chr1_23974566_-SINEAluName=AluSx
ADediting_80687chr1_23974584_-SINEAluName=AluSx
ADediting_80688chr1_23974594_-SINEAluName=AluSx
ADediting_80689chr1_23974612_-SINEAluName=AluSx
ADediting_80690chr1_23974646_-SINEAluName=AluSx
ADediting_80691chr1_23974649_-SINEAluName=AluSx
ADediting_80692chr1_23974655_-SINEAluName=AluSx
ADediting_80693chr1_23974663_-SINEAluName=AluSx
ADediting_80694chr1_23974666_-SINEAluName=AluSx
ADediting_80695chr1_23974689_-SINEAluName=AluSx
ADediting_80696chr1_23974707_-SINEAluName=AluSx
ADediting_80697chr1_23974717_-SINEAluName=AluSx
ADediting_80698chr1_23974728_-SINEAluName=AluSx
ADediting_80699chr1_23974729_-SINEAluName=AluSx
ADediting_80700chr1_23974760_-SINEAluName=AluSx
ADediting_80701chr1_23974766_-SINEAluName=AluSx
ADediting_80702chr1_23974767_-SINEAluName=AluSx
ADediting_80703chr1_23974772_-SINEAluName=AluSx
ADediting_80704chr1_23974819_-SINEAluName=AluSx
ADediting_80705chr1_23974831_-SINEAluName=AluSx
ADediting_1518140chr1_23972152_-SINEAluName=AluJo
ADediting_1518141chr1_23972334_-SINEAluName=AluJo
ADediting_1518142chr1_23972575_-SINEAluName=AluSz
ADediting_1518143chr1_23972580_-SINEAluName=AluSz
ADediting_1518144chr1_23972715_-SINEAluName=AluSz
ADediting_1518145chr1_23973026_-SINEAluName=AluSp
ADediting_1518146chr1_23973468_-SINEAluName=AluJo
ADediting_1518147chr1_23974156_-SINEAluName=AluSx3
ADediting_1518148chr1_23974782_-SINEAluName=AluSx

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RNA A-to-I editing events in the alternative splicing sites for SRSF10

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESADediting_80693chr1_23974663_-23974659:239746813ss2iGATTTTTGTATTTTTAGTAGAGA2.45GATTTTTGTATTTTTAGTGGAGA-5.50
ESADediting_80694chr1_23974666_-23974659:239746813ss5iGATTTTTGTATTTTTAGTAGAGA2.45GATTTTTGTATTTTTGGTAGAGA3.87

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SRSF10

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for SRSF10

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for SRSF10


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000188529.15ENST00000344989.10SRSF10-204hsa-miR-5688chr123965119239651257mer-m82396511823965139145-11.33
ADediting_1097295chr3_85385762_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-5688chr123965119239651257mer-m82396511823965139145-11.33
ADediting_1471004chr9_63819627_+ENSG00000188529.15ENST00000344989.10SRSF10-204hsa-miR-4477bchr123967439239674468mer-1a2396743923967458144-9.12
ADediting_1471004chr9_63819627_+ENSG00000188529.15ENST00000374452.9SRSF10-205hsa-miR-4477bchr123967439239674468mer-1a2396743923967458144-9.12
ADediting_1471004chr9_63819627_+ENSG00000188529.15ENST00000453840.7SRSF10-207hsa-miR-4477bchr123967439239674468mer-1a2396743923967458144-9.12
ADediting_1471004chr9_63819627_+ENSG00000188529.15ENST00000484146.6SRSF10-211hsa-miR-4477bchr123967439239674468mer-1a2396743923967458144-9.12
ADediting_1471004chr9_63819627_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-4477bchr123967439239674468mer-1a2396743923967458144-9.12
ADediting_1535953chr14_101045971_+ENSG00000188529.15ENST00000344989.10SRSF10-204hsa-miR-381-3pchr123965480239654878mer-1a2396548023965498155-16.29
ADediting_1535953chr14_101045971_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-381-3pchr123965480239654878mer-1a2396548023965498155-16.29
ADediting_1535954chr14_101045974_+ENSG00000188529.15ENST00000343255.9SRSF10-203hsa-miR-381-3pchr123970913239709197mer-1a2397091323970934140-17.24
ADediting_1535954chr14_101045974_+ENSG00000188529.15ENST00000374452.9SRSF10-205hsa-miR-381-3pchr123967778239677858mer-1a2396777823967799141-12.98
ADediting_1535954chr14_101045974_+ENSG00000188529.15ENST00000374453.7SRSF10-206hsa-miR-381-3pchr123967778239677858mer-1a2396777823967799141-12.98
ADediting_1535954chr14_101045974_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-381-3pchr123967778239677858mer-1a2396777823967799141-12.98
ADediting_1535954chr14_101045974_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-381-3pchr123970913239709197mer-1a2397091323970934140-17.24
ADediting_1556067chr19_40282625_-ENSG00000188529.15ENST00000344989.10SRSF10-204hsa-miR-641chr123967317239673237mer-1a2396731723967341140-19.61
ADediting_1556067chr19_40282625_-ENSG00000188529.15ENST00000374452.9SRSF10-205hsa-miR-641chr123967317239673237mer-1a2396731723967341140-19.61
ADediting_1556067chr19_40282625_-ENSG00000188529.15ENST00000453840.7SRSF10-207hsa-miR-641chr123967317239673237mer-1a2396731723967341140-19.61
ADediting_1556067chr19_40282625_-ENSG00000188529.15ENST00000484146.6SRSF10-211hsa-miR-641chr123967317239673237mer-1a2396731723967341140-19.61
ADediting_1556067chr19_40282625_-ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-641chr123967317239673237mer-1a2396731723967341140-19.61
ADediting_843620chr2_207754818_+ENSG00000188529.15ENST00000343255.9SRSF10-203hsa-miR-4775chr123970423239704297mer-m82397042223970443144-9.77
ADediting_843620chr2_207754818_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-4775chr123970423239704297mer-m82397042223970443144-9.77

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000188529.15ENST00000343255.9SRSF10-203hsa-miR-5688chr123970954239709607mer-m82397095323970977145-13.36
ADediting_1097295chr3_85385762_+ENSG00000188529.15ENST00000344989.10SRSF10-204hsa-miR-5688chr123966104239661107mer-m82396610323966123154-12.09
ADediting_1097295chr3_85385762_+ENSG00000188529.15ENST00000344989.10SRSF10-204hsa-miR-5688chr123966115239661217mer-1a2396610323966123154-12.09
ADediting_1097295chr3_85385762_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-5688chr123966104239661107mer-m82396610323966123154-12.09
ADediting_1097295chr3_85385762_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-5688chr123966115239661217mer-1a2396610323966123154-12.09
ADediting_1097295chr3_85385762_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-5688chr123968385239683917mer-m82396838423968410154-17.21
ADediting_1097295chr3_85385762_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-5688chr123970954239709607mer-m82397095323970977145-13.36
ADediting_1337757chr7_5495852_-ENSG00000188529.15ENST00000343255.9SRSF10-203hsa-miR-589-3pchr123969391239693977mer-m82396939023969415145-9.87
ADediting_1337757chr7_5495852_-ENSG00000188529.15ENST00000344989.10SRSF10-204hsa-miR-589-3pchr123966482239664887mer-m82396648123966504146-18.49
ADediting_1337757chr7_5495852_-ENSG00000188529.15ENST00000344989.10SRSF10-204hsa-miR-589-3pchr123966554239665607mer-m82396655323966579145-13.22
ADediting_1337757chr7_5495852_-ENSG00000188529.15ENST00000453840.7SRSF10-207hsa-miR-589-3pchr123966482239664887mer-m82396648123966504146-18.49
ADediting_1337757chr7_5495852_-ENSG00000188529.15ENST00000453840.7SRSF10-207hsa-miR-589-3pchr123966554239665607mer-m82396655323966579145-13.22
ADediting_1337757chr7_5495852_-ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-589-3pchr123966482239664887mer-m82396648123966504146-18.49
ADediting_1337757chr7_5495852_-ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-589-3pchr123966554239665607mer-m82396655323966579145-13.22
ADediting_1337757chr7_5495852_-ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-589-3pchr123969391239693977mer-m82396939023969415145-9.87
ADediting_1337758chr7_5495892_-ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-589-5pchr123964421239644277mer-m82396442023964442148-16.72
ADediting_1535953chr14_101045971_+ENSG00000188529.15ENST00000344989.10SRSF10-204hsa-miR-381-3pchr123964970239649767mer-m82396496923964991154-20.82
ADediting_1535953chr14_101045971_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-381-3pchr123964970239649767mer-m82396496923964991154-20.82
ADediting_1535954chr14_101045974_+ENSG00000188529.15ENST00000344989.10SRSF10-204hsa-miR-381-3pchr123964970239649767mer-m82396496923964991154-20.82
ADediting_1535954chr14_101045974_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-381-3pchr123964970239649767mer-m82396496923964991154-20.82
ADediting_1556067chr19_40282625_-ENSG00000188529.15ENST00000343255.9SRSF10-203hsa-miR-641chr123970677239706837mer-m82397067623970696154-19.5
ADediting_1556067chr19_40282625_-ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-641chr123970677239706837mer-m82397067623970696154-19.5
ADediting_1631458chr19_40282624_-ENSG00000188529.15ENST00000343255.9SRSF10-203hsa-miR-641chr123970677239706837mer-m82397067623970696154-19.5
ADediting_1631458chr19_40282624_-ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-641chr123970677239706837mer-m82397067623970696154-19.5
ADediting_1643790chr3_121049689_+ENSG00000188529.15ENST00000344989.10SRSF10-204hsa-miR-5682chr123966614239666207mer-m82396661323966634143-14.35
ADediting_1643790chr3_121049689_+ENSG00000188529.15ENST00000374452.9SRSF10-205hsa-miR-5682chr123967899239679057mer-m82396789823967919152-17.23
ADediting_1643790chr3_121049689_+ENSG00000188529.15ENST00000374453.7SRSF10-206hsa-miR-5682chr123967899239679057mer-m82396789823967919152-17.23
ADediting_1643790chr3_121049689_+ENSG00000188529.15ENST00000453840.7SRSF10-207hsa-miR-5682chr123966614239666207mer-m82396661323966634143-14.35
ADediting_1643790chr3_121049689_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-5682chr123966614239666207mer-m82396661323966634143-14.35
ADediting_1643790chr3_121049689_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-5682chr123967899239679057mer-m82396789823967919152-17.23
ADediting_291761chr11_93733708_-ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-1304-3pchr123967913239679208mer-1a2396791323967934154-18.54
ADediting_496066chr15_66496985_-ENSG00000188529.15ENST00000344989.10SRSF10-204hsa-miR-4512chr123965709239657157mer-m82396570823965730147-19.27
ADediting_496066chr15_66496985_-ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-4512chr123965709239657157mer-m82396570823965730147-19.27
ADediting_843620chr2_207754818_+ENSG00000188529.15ENST00000344989.10SRSF10-204hsa-miR-4775chr123965789239657957mer-m82396578823965809152-8.48
ADediting_843620chr2_207754818_+ENSG00000188529.15ENST00000344989.10SRSF10-204hsa-miR-4775chr123966323239663308mer-1a2396632323966344148-5.46
ADediting_843620chr2_207754818_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-4775chr123965789239657957mer-m82396578823965809152-8.48
ADediting_843620chr2_207754818_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-4775chr123966323239663308mer-1a2396632323966344148-5.46
ADediting_98288chr1_32086990_+ENSG00000188529.15ENST00000344989.10SRSF10-204hsa-miR-5585-3pchr123965468239654747mer-m82396546723965488149-13.61
ADediting_98288chr1_32086990_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-5585-3pchr123965468239654747mer-m82396546723965488149-13.61
ADediting_98289chr1_32086992_+ENSG00000188529.15ENST00000344989.10SRSF10-204hsa-miR-5585-3pchr123965468239654747mer-m82396546723965488149-13.61
ADediting_98289chr1_32086992_+ENSG00000188529.15ENST00000492112.3SRSF10-214hsa-miR-5585-3pchr123965468239654747mer-m82396546723965488149-13.61

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SRSF10

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for SRSF10

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CERADediting_80642chr1_23972161_-2.14045772739262e-060.3758528676505712.89642932858015e-100.4859839052353890.06871915753340910.149039320686156
CERADediting_80644chr1_23972174_-3.88238937279815e-050.3292744504333311.23686830565496e-060.3839025566097430.1640526117574250.114204492064763
CERADediting_80645chr1_23972179_-2.3744136236198e-050.3377165685516423.1075890431552e-090.4602590027901380.009028880349396260.212520733724859
DLPFCADediting_80646chr1_23972191_-0.00696250993420170.1529867583623260.937644071223533-0.004461239015563173.39812730047787e-190.479110180870698
CERADediting_80646chr1_23972191_-1.47751526245224e-050.3456352550847964.72984501558007e-090.4554748553020110.008537055948489770.2140391998543
CERADediting_80648chr1_23972204_-0.0007639175476151960.2718753010030282.28870122791581e-070.407406736987110.04470196966820160.164166995286235
CERADediting_80649chr1_23972205_-1.40453783902382e-050.3464682403022264.78664233999449e-100.480712979348910.06958319822633980.148582076936552
CERADediting_80650chr1_23972206_-1.21759285192294e-060.3841299622687991.47527534554041e-090.4685672333792290.2719009843733670.0902800036633103
CERADediting_80653chr1_23972244_-5.25398195211497e-050.3239544494898697.71869312887324e-100.4756150286330960.02900723509812130.178333170839884
CERADediting_80658chr1_23972581_-0.003077331325688330.2401375716600468.56492002390677e-050.3151458986028530.7662444128148460.0244748082350775
CERADediting_80661chr1_23972853_-0.002142661951117720.2487694665647162.74389340387448e-060.3721355835552510.4260586767706070.0654672897978145
CERADediting_80663chr1_23972880_-0.0009216928910877650.2678187728883151.29362833139834e-070.4149629700978670.7827621760093340.0226995363407201
CERADediting_80664chr1_23972953_-0.0003180265740790290.2900335315045526.55938057178984e-060.3587131925888180.3041165694382140.0844634433554156
CERADediting_80666chr1_23973019_-1.19647515900955e-060.3843830710000421.04172809379188e-080.446277488284730.1468235693298240.119035012989376
CERADediting_80668chr1_23973521_-0.001865744858081280.2519928101971940.0001783695613134470.30138391807350.6987552561581860.03185699836414
DLPFCADediting_80670chr1_23973594_-0.4804113358709930.04022399557562710.171836320426843-0.07779878833530563.2966526546081e-100.347156631445224
CERADediting_80670chr1_23973594_-0.0001480186632622220.3049476579757363.24269112181978e-070.4026989923240270.1114920099003970.130482632570559
DLPFCADediting_80672chr1_23973607_-0.2366138414915170.06741372575937850.211202121646422-0.07120786879170661.59412195664347e-140.417760059065955
CERADediting_80672chr1_23973607_-1.21352413906575e-050.3488589518812942.96993470662304e-100.4857230611555310.0396220650338060.168215906391689
CERADediting_80676chr1_23974130_-3.79734385069063e-050.3296600883586752.47065792008168e-080.4358954845571090.319836582379040.0817725135974635
DLPFCADediting_80677chr1_23974136_-0.287096073085061-0.06064964896942080.00582850872127006-0.1562708214017151.14068719429207e-080.317089517990432
CERADediting_80679chr1_23974159_-0.0007517349686737620.2722197570728464.18589974687972e-060.3657063659783230.3717981214555680.0734379632977984
CERADediting_80681chr1_23974166_-2.00718004002106e-050.3405458809829292.9528414278998e-080.433708210031810.1606616690658030.115124051522908
CERADediting_80684chr1_23974189_-1.10872270625667e-050.3503264344845444.61905688166084e-080.428149941496780.3047420130280960.0843546648101046
CERADediting_80686chr1_23974566_-0.0003586324883942450.2876147898866065.30331023853675e-060.3620431016840010.02647572382019720.181206916511053
DLPFCADediting_80688chr1_23974594_-0.8309410215654240.01217442383009120.232555220209224-0.06799962287679341.49811410445697e-110.370999753056709
CERADediting_80688chr1_23974594_-2.91810671107028e-090.4609692470106581.18207717651728e-120.5384866891550530.001270626612922390.260733411307548
CERADediting_80690chr1_23974646_-0.001139471723064570.263159369636223.33358956781142e-050.3319175372911650.575848821688501-0.0460405143183209
CERADediting_80693chr1_23974663_-4.42385184187222e-060.3648543850683491.68581937576915e-080.4405335121995340.2995066305021480.0852697931750573
CERADediting_80694chr1_23974666_-4.85333225604841e-050.3253588601905463.00832563905429e-060.370746722087090.06219422279641960.152652477036417
CERADediting_80695chr1_23974689_-0.001136637078634940.2632145698746832.17985046786259e-060.3755814714792530.2991533385799990.0853319261114037
CERADediting_80696chr1_23974707_-5.73619156686802e-060.3608182708587172.99388315891841e-110.5087382459526510.07550242975087030.145567822780423
CERADediting_80698chr1_23974728_-2.02142442030146e-060.3767027875234291.36254973587224e-110.5162547573412770.03324850738647730.173965302544743
CERADediting_80700chr1_23974760_-0.0001333812566905650.3069175105855691.12917647507738e-090.471495427676580.01664281942733240.195258225244043
CERADediting_80701chr1_23974766_-2.94667735034974e-050.3340395706554742.37247716709999e-100.4880530195616490.006503139232744020.221280629853208
CERADediting_80702chr1_23974767_-0.0003714591187737740.2869033653831433.23038374953243e-080.4326002091406350.04286960935822280.165580822455014
CERADediting_80703chr1_23974772_-4.63837013458448e-050.3261578818334419.2675124473381e-100.4736415772748750.04268880863213030.165723049962015
CERADediting_80704chr1_23974819_-0.0001104513264318990.3104511649064931.1248580051608e-080.4453684552431680.01720499949719340.194281852398741
CERADediting_80705chr1_23974831_-0.0006337597260173440.2758502639566991.69669420779654e-060.3792892673412380.03019053095226120.177062675373909

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC2.51851291799925e-450.6910162882161964.71859510482782e-350.6254181315231060.002435548030030470.171577302844094
AC4.76986494525397e-570.8004297665560939.04674549917692e-320.6529777156209531.23678500482412e-200.543717102618221
PCC4.96264654191804e-180.5725903045698511.4671829935947e-170.5658514293215344.87333549462387e-050.289471780245979
CER5.26247099523888e-480.8730094902846313.02826251492812e-340.7971633780754920.002052877963784670.24977088226007
TCX1.19556814365682e-330.7928859595388631.50567548174216e-060.3810407215864378.72404996584502e-100.47429511457781
FP4.71559371145436e-420.8066513943906438.61727951959095e-240.6617735260245855.92805363968727e-050.296287226008465
IFG2.64655614201293e-080.8639205786891761.45752554342326e-060.8016598392278880.007205322084149790.523770048153687
PG8.83210076492092e-570.8641910859422825.32574342645898e-270.6839958537146270.4655756638723830.0538280153576578
STG4.30429885049654e-200.8026445597870653.77181508580033e-120.6682954370768440.1752817023901580.149295866219423

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Relation with AD stages for SRSF10

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
CERADediting_80686chr1_23974566_-0.00114968540743070.308747869188012
CERADediting_80688chr1_23974594_-0.0005577833286816640.326744413221944
CERADediting_80696chr1_23974707_-0.001249041229879150.306612366657542
CERADediting_80701chr1_23974766_-0.0003097933882732840.340606075773198
CERADediting_80702chr1_23974767_-0.000785203580885950.318373617296505

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER3.17251882645812e-060.431240635741795
TCX8.51776198916366e-080.491965810404375

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RelatedDrugs for SRSF10

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SRSF10

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
SRSF10C0014170Endometrial Neoplasms1CTD_human
SRSF10C0032460Polycystic Ovary Syndrome1CTD_human
SRSF10C0036341Schizophrenia1PSYGENET
SRSF10C0476089Endometrial Carcinoma1CTD_human
SRSF10C0919267ovarian neoplasm1CTD_human
SRSF10C1136382Sclerocystic Ovaries1CTD_human
SRSF10C1140680Malignant neoplasm of ovary1CTD_human