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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for SPTLC1 |
 Gene summary |
| Gene information | Gene symbol | SPTLC1 | Gene ID | 10558 |
| Gene name | serine palmitoyltransferase long chain base subunit 1 | |
| Synonyms | HSAN1|HSN1|LBC1|LCB1|SPT1|SPTI | |
| Cytomap | 9q22.31 | |
| Type of gene | protein-coding | |
| Description | serine palmitoyltransferase 1long chain base biosynthesis protein 1serine C-palmitoyltransferaseserine-palmitoyl-CoA transferase 1 | |
| Modification date | 20200313 | |
| UniProtAcc | O15269, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| SPTLC1 | GO:0030148 | sphingolipid biosynthetic process | 25332431 |
| SPTLC1 | GO:0046513 | ceramide biosynthetic process | 25691431 |
| SPTLC1 | GO:1904504 | positive regulation of lipophagy | 25332431 |
Top |
RNA A-to-I events for SPTLC1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_1478853(92032621, -), ADediting_1478854(92032633, -), ADediting_1478855(92032634, -), ADediting_1478856(92032651, -), ADediting_1478857(92032683, -), ADediting_1478858(92032687, -), ADediting_1478859(92032752, -), ADediting_1478860(92032754, -), ADediting_1478861(92032764, -), ADediting_1478862(92032767, -), ADediting_1478863(92032837, -), ADediting_1478864(92033618, -), ADediting_1478865(92033628, -), ADediting_1478866(92033640, -), ADediting_1478867(92033684, -), ADediting_1478868(92033688, -), ADediting_1478869(92033720, -), ADediting_1478870(92033741, -), ADediting_1478871(92033750, -), ADediting_1478872(92033760, -), ADediting_1478873(92033763, -), ADediting_1478874(92033765, -), ADediting_1478875(92033766, -), ADediting_1478876(92033768, -), ADediting_1478877(92033771, -), ADediting_1478878(92033774, -), ADediting_1478879(92033789, -), ADediting_1478880(92033810, -), ADediting_1478881(92033812, -), ADediting_1478882(92033818, -), ADediting_1478883(92033825, -), ADediting_1478884(92033841, -), ADediting_1478885(92050889, -), ADediting_1478886(92050910, -), ADediting_1478887(92050915, -), ADediting_1478888(92050924, -), ADediting_1478889(92050957, -), ADediting_1478890(92052805, -), ADediting_1478891(92052813, -), ADediting_1478892(92054037, -), ADediting_1478893(92054071, -), ADediting_1478894(92054156, -), ADediting_1478895(92054268, -), ADediting_1478896(92054669, -), ADediting_1478897(92054670, -), ADediting_1478898(92054733, -), ADediting_1478899(92054813, -), ADediting_1478900(92054827, -), ADediting_1478901(92054830, -), ADediting_1478902(92054831, -), ADediting_1478903(92054855, -), ADediting_1478904(92054865, -), ADediting_1478905(92055169, -), ADediting_1478906(92055174, -), ADediting_1478907(92071115, -), ADediting_1478908(92071124, -), ADediting_1478909(92071133, -), ADediting_1478910(92071224, -), ADediting_1478911(92071227, -), ADediting_1478912(92071272, -), ADediting_1478913(92071276, -), ADediting_1478914(92071278, -), ADediting_1478915(92071300, -), ADediting_1478916(92071337, -), ADediting_1478917(92071353, -), ADediting_1478918(92071361, -), ADediting_1478919(92071373, -), ADediting_1478920(92071387, -), ADediting_1478921(92071397, -), ADediting_1478922(92078519, -), ADediting_1478923(92078534, -), ADediting_1478924(92078570, -), ADediting_1478925(92078610, -), ADediting_1478926(92078706, -), ADediting_1478927(92078744, -), ADediting_1478928(92079148, -), ADediting_1478929(92079161, -), ADediting_1478930(92079165, -), ADediting_1478931(92079173, -), ADediting_1478932(92079181, -), ADediting_1478933(92079184, -), ADediting_1478934(92079204, -), ADediting_1478935(92079208, -), ADediting_1478936(92079213, -), ADediting_1478937(92079214, -), ADediting_1478938(92079220, -), ADediting_1478939(92079222, -), ADediting_1478940(92079240, -), ADediting_1478941(92079255, -), ADediting_1478942(92079258, -), ADediting_1478943(92079269, -), ADediting_1478944(92079270, -), ADediting_1478945(92079277, -), ADediting_1478946(92079303, -), ADediting_1478947(92079318, -), ADediting_1478948(92079322, -), ADediting_1478949(92079326, -), ADediting_1478950(92079332, -), ADediting_1478951(92079333, -), ADediting_1478952(92079348, -), ADediting_1478953(92079349, -), ADediting_1478954(92079367, -), ADediting_1478956(92107588, -), ADediting_1478957(92107628, -), ADediting_1594282(92032624, -), ADediting_1594283(92032695, -), ADediting_1594284(92033677, -), ADediting_1594285(92033740, -), ADediting_1594286(92033742, -), ADediting_1594287(92033801, -), ADediting_1594288(92033827, -), ADediting_1594289(92055164, -), ADediting_1594290(92078597, -), ADediting_1594291(92078721, -), ADediting_1594292(92078728, -), ADediting_1594293(92079197, -), |
Top |
RNA editing positional annotations for SPTLC1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1478853 | chr9_92032621_- | intronic |
| ADediting_1478854 | chr9_92032633_- | intronic |
| ADediting_1478855 | chr9_92032634_- | intronic |
| ADediting_1478856 | chr9_92032651_- | intronic |
| ADediting_1478857 | chr9_92032683_- | intronic |
| ADediting_1478858 | chr9_92032687_- | intronic |
| ADediting_1478859 | chr9_92032752_- | intronic |
| ADediting_1478860 | chr9_92032754_- | intronic |
| ADediting_1478861 | chr9_92032764_- | intronic |
| ADediting_1478862 | chr9_92032767_- | intronic |
| ADediting_1478863 | chr9_92032837_- | intronic |
| ADediting_1478864 | chr9_92033618_- | intronic |
| ADediting_1478865 | chr9_92033628_- | intronic |
| ADediting_1478866 | chr9_92033640_- | intronic |
| ADediting_1478867 | chr9_92033684_- | intronic |
| ADediting_1478868 | chr9_92033688_- | intronic |
| ADediting_1478869 | chr9_92033720_- | intronic |
| ADediting_1478870 | chr9_92033741_- | intronic |
| ADediting_1478871 | chr9_92033750_- | intronic |
| ADediting_1478872 | chr9_92033760_- | intronic |
| ADediting_1478873 | chr9_92033763_- | intronic |
| ADediting_1478874 | chr9_92033765_- | intronic |
| ADediting_1478875 | chr9_92033766_- | intronic |
| ADediting_1478876 | chr9_92033768_- | intronic |
| ADediting_1478877 | chr9_92033771_- | intronic |
| ADediting_1478878 | chr9_92033774_- | intronic |
| ADediting_1478879 | chr9_92033789_- | intronic |
| ADediting_1478880 | chr9_92033810_- | intronic |
| ADediting_1478881 | chr9_92033812_- | intronic |
| ADediting_1478882 | chr9_92033818_- | intronic |
| ADediting_1478883 | chr9_92033825_- | intronic |
| ADediting_1478884 | chr9_92033841_- | intronic |
| ADediting_1478885 | chr9_92050889_- | intronic |
| ADediting_1478886 | chr9_92050910_- | intronic |
| ADediting_1478887 | chr9_92050915_- | intronic |
| ADediting_1478888 | chr9_92050924_- | intronic |
| ADediting_1478889 | chr9_92050957_- | intronic |
| ADediting_1478890 | chr9_92052805_- | intronic |
| ADediting_1478891 | chr9_92052813_- | intronic |
| ADediting_1478892 | chr9_92054037_- | intronic |
| ADediting_1478893 | chr9_92054071_- | intronic |
| ADediting_1478894 | chr9_92054156_- | intronic |
| ADediting_1478895 | chr9_92054268_- | intronic |
| ADediting_1478896 | chr9_92054669_- | intronic |
| ADediting_1478897 | chr9_92054670_- | intronic |
| ADediting_1478898 | chr9_92054733_- | intronic |
| ADediting_1478899 | chr9_92054813_- | intronic |
| ADediting_1478900 | chr9_92054827_- | intronic |
| ADediting_1478901 | chr9_92054830_- | intronic |
| ADediting_1478902 | chr9_92054831_- | intronic |
| ADediting_1478903 | chr9_92054855_- | intronic |
| ADediting_1478904 | chr9_92054865_- | intronic |
| ADediting_1478905 | chr9_92055169_- | intronic |
| ADediting_1478906 | chr9_92055174_- | intronic |
| ADediting_1478907 | chr9_92071115_- | intronic |
| ADediting_1478908 | chr9_92071124_- | intronic |
| ADediting_1478909 | chr9_92071133_- | intronic |
| ADediting_1478910 | chr9_92071224_- | intronic |
| ADediting_1478911 | chr9_92071227_- | intronic |
| ADediting_1478912 | chr9_92071272_- | intronic |
| ADediting_1478913 | chr9_92071276_- | intronic |
| ADediting_1478914 | chr9_92071278_- | intronic |
| ADediting_1478915 | chr9_92071300_- | intronic |
| ADediting_1478916 | chr9_92071337_- | intronic |
| ADediting_1478917 | chr9_92071353_- | intronic |
| ADediting_1478918 | chr9_92071361_- | intronic |
| ADediting_1478919 | chr9_92071373_- | intronic |
| ADediting_1478920 | chr9_92071387_- | intronic |
| ADediting_1478921 | chr9_92071397_- | intronic |
| ADediting_1478922 | chr9_92078519_- | intronic |
| ADediting_1478923 | chr9_92078534_- | intronic |
| ADediting_1478924 | chr9_92078570_- | intronic |
| ADediting_1478925 | chr9_92078610_- | intronic |
| ADediting_1478926 | chr9_92078706_- | intronic |
| ADediting_1478927 | chr9_92078744_- | intronic |
| ADediting_1478928 | chr9_92079148_- | UTR3 |
| ADediting_1478929 | chr9_92079161_- | UTR3 |
| ADediting_1478930 | chr9_92079165_- | UTR3 |
| ADediting_1478931 | chr9_92079173_- | UTR3 |
| ADediting_1478932 | chr9_92079181_- | UTR3 |
| ADediting_1478933 | chr9_92079184_- | UTR3 |
| ADediting_1478934 | chr9_92079204_- | UTR3 |
| ADediting_1478935 | chr9_92079208_- | UTR3 |
| ADediting_1478936 | chr9_92079213_- | UTR3 |
| ADediting_1478937 | chr9_92079214_- | UTR3 |
| ADediting_1478938 | chr9_92079220_- | UTR3 |
| ADediting_1478939 | chr9_92079222_- | UTR3 |
| ADediting_1478940 | chr9_92079240_- | UTR3 |
| ADediting_1478941 | chr9_92079255_- | UTR3 |
| ADediting_1478942 | chr9_92079258_- | UTR3 |
| ADediting_1478943 | chr9_92079269_- | UTR3 |
| ADediting_1478944 | chr9_92079270_- | UTR3 |
| ADediting_1478945 | chr9_92079277_- | UTR3 |
| ADediting_1478946 | chr9_92079303_- | UTR3 |
| ADediting_1478947 | chr9_92079318_- | UTR3 |
| ADediting_1478948 | chr9_92079322_- | UTR3 |
| ADediting_1478949 | chr9_92079326_- | UTR3 |
| ADediting_1478950 | chr9_92079332_- | UTR3 |
| ADediting_1478951 | chr9_92079333_- | UTR3 |
| ADediting_1478952 | chr9_92079348_- | UTR3 |
| ADediting_1478953 | chr9_92079349_- | UTR3 |
| ADediting_1478954 | chr9_92079367_- | UTR3 |
| ADediting_1478956 | chr9_92107588_- | intronic |
| ADediting_1478957 | chr9_92107628_- | intronic |
| ADediting_1594282 | chr9_92032624_- | intronic |
| ADediting_1594283 | chr9_92032695_- | intronic |
| ADediting_1594284 | chr9_92033677_- | intronic |
| ADediting_1594285 | chr9_92033740_- | intronic |
| ADediting_1594286 | chr9_92033742_- | intronic |
| ADediting_1594287 | chr9_92033801_- | intronic |
| ADediting_1594288 | chr9_92033827_- | intronic |
| ADediting_1594289 | chr9_92055164_- | intronic |
| ADediting_1594290 | chr9_92078597_- | intronic |
| ADediting_1594291 | chr9_92078721_- | intronic |
| ADediting_1594292 | chr9_92078728_- | intronic |
| ADediting_1594293 | chr9_92079197_- | UTR3 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1478853 | chr9_92032621_- | SINE | Alu | Name=AluY |
| ADediting_1478854 | chr9_92032633_- | SINE | Alu | Name=AluY |
| ADediting_1478855 | chr9_92032634_- | SINE | Alu | Name=AluY |
| ADediting_1478856 | chr9_92032651_- | SINE | Alu | Name=AluY |
| ADediting_1478857 | chr9_92032683_- | SINE | Alu | Name=AluY |
| ADediting_1478858 | chr9_92032687_- | SINE | Alu | Name=AluY |
| ADediting_1478859 | chr9_92032752_- | SINE | Alu | Name=AluY |
| ADediting_1478860 | chr9_92032754_- | SINE | Alu | Name=AluY |
| ADediting_1478861 | chr9_92032764_- | SINE | Alu | Name=AluY |
| ADediting_1478862 | chr9_92032767_- | SINE | Alu | Name=AluY |
| ADediting_1478863 | chr9_92032837_- | SINE | Alu | Name=AluY |
| ADediting_1478864 | chr9_92033618_- | SINE | Alu | Name=AluJb |
| ADediting_1478865 | chr9_92033628_- | SINE | Alu | Name=AluJb |
| ADediting_1478866 | chr9_92033640_- | SINE | Alu | Name=AluJb |
| ADediting_1478867 | chr9_92033684_- | SINE | Alu | Name=AluJb |
| ADediting_1478868 | chr9_92033688_- | SINE | Alu | Name=AluJb |
| ADediting_1478869 | chr9_92033720_- | SINE | Alu | Name=AluJb |
| ADediting_1478870 | chr9_92033741_- | SINE | Alu | Name=AluJb |
| ADediting_1478871 | chr9_92033750_- | SINE | Alu | Name=AluJb |
| ADediting_1478872 | chr9_92033760_- | SINE | Alu | Name=AluJb |
| ADediting_1478873 | chr9_92033763_- | SINE | Alu | Name=AluJb |
| ADediting_1478874 | chr9_92033765_- | SINE | Alu | Name=AluJb |
| ADediting_1478875 | chr9_92033766_- | SINE | Alu | Name=AluJb |
| ADediting_1478876 | chr9_92033768_- | SINE | Alu | Name=AluJb |
| ADediting_1478877 | chr9_92033771_- | SINE | Alu | Name=AluJb |
| ADediting_1478878 | chr9_92033774_- | SINE | Alu | Name=AluJb |
| ADediting_1478879 | chr9_92033789_- | SINE | Alu | Name=AluJb |
| ADediting_1478880 | chr9_92033810_- | SINE | Alu | Name=AluJb |
| ADediting_1478881 | chr9_92033812_- | SINE | Alu | Name=AluJb |
| ADediting_1478882 | chr9_92033818_- | SINE | Alu | Name=AluJb |
| ADediting_1478883 | chr9_92033825_- | SINE | Alu | Name=AluJb |
| ADediting_1478884 | chr9_92033841_- | SINE | Alu | Name=AluJb |
| ADediting_1478885 | chr9_92050889_- | SINE | Alu | Name=AluJb |
| ADediting_1478886 | chr9_92050910_- | SINE | Alu | Name=AluJb |
| ADediting_1478887 | chr9_92050915_- | SINE | Alu | Name=AluJb |
| ADediting_1478888 | chr9_92050924_- | SINE | Alu | Name=AluJb |
| ADediting_1478889 | chr9_92050957_- | SINE | Alu | Name=AluJb |
| ADediting_1478890 | chr9_92052805_- | SINE | Alu | Name=AluSz |
| ADediting_1478891 | chr9_92052813_- | SINE | Alu | Name=AluSz |
| ADediting_1478892 | chr9_92054037_- | SINE | Alu | Name=AluSp |
| ADediting_1478893 | chr9_92054071_- | SINE | Alu | Name=AluSp |
| ADediting_1478894 | chr9_92054156_- | SINE | Alu | Name=AluSp |
| ADediting_1478895 | chr9_92054268_- | SINE | Alu | Name=AluSp |
| ADediting_1478896 | chr9_92054669_- | SINE | Alu | Name=AluSc |
| ADediting_1478897 | chr9_92054670_- | SINE | Alu | Name=AluSc |
| ADediting_1478898 | chr9_92054733_- | SINE | Alu | Name=AluSc |
| ADediting_1478899 | chr9_92054813_- | SINE | Alu | Name=AluSc |
| ADediting_1478900 | chr9_92054827_- | SINE | Alu | Name=AluSc |
| ADediting_1478901 | chr9_92054830_- | SINE | Alu | Name=AluSc |
| ADediting_1478902 | chr9_92054831_- | SINE | Alu | Name=AluSc |
| ADediting_1478903 | chr9_92054855_- | SINE | Alu | Name=AluSc |
| ADediting_1478904 | chr9_92054865_- | SINE | Alu | Name=AluSc |
| ADediting_1478905 | chr9_92055169_- | SINE | Alu | Name=AluJo |
| ADediting_1478906 | chr9_92055174_- | SINE | Alu | Name=AluJo |
| ADediting_1478907 | chr9_92071115_- | SINE | Alu | Name=AluSp |
| ADediting_1478908 | chr9_92071124_- | SINE | Alu | Name=AluSp |
| ADediting_1478909 | chr9_92071133_- | SINE | Alu | Name=AluSp |
| ADediting_1478910 | chr9_92071224_- | SINE | Alu | Name=AluSp |
| ADediting_1478911 | chr9_92071227_- | SINE | Alu | Name=AluSp |
| ADediting_1478912 | chr9_92071272_- | SINE | Alu | Name=AluSp |
| ADediting_1478913 | chr9_92071276_- | SINE | Alu | Name=AluSp |
| ADediting_1478914 | chr9_92071278_- | SINE | Alu | Name=AluSp |
| ADediting_1478915 | chr9_92071300_- | SINE | Alu | Name=AluSp |
| ADediting_1478916 | chr9_92071337_- | SINE | Alu | Name=AluSp |
| ADediting_1478917 | chr9_92071353_- | SINE | Alu | Name=AluSp |
| ADediting_1478918 | chr9_92071361_- | SINE | Alu | Name=AluSp |
| ADediting_1478919 | chr9_92071373_- | SINE | Alu | Name=AluSp |
| ADediting_1478920 | chr9_92071387_- | SINE | Alu | Name=AluSp |
| ADediting_1478921 | chr9_92071397_- | SINE | Alu | Name=AluSp |
| ADediting_1478922 | chr9_92078519_- | SINE | Alu | Name=AluJb |
| ADediting_1478923 | chr9_92078534_- | SINE | Alu | Name=AluJb |
| ADediting_1478924 | chr9_92078570_- | SINE | Alu | Name=AluJb |
| ADediting_1478925 | chr9_92078610_- | SINE | Alu | Name=AluJb |
| ADediting_1478926 | chr9_92078706_- | SINE | Alu | Name=AluJb |
| ADediting_1478927 | chr9_92078744_- | SINE | Alu | Name=AluJb |
| ADediting_1478928 | chr9_92079148_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478929 | chr9_92079161_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478930 | chr9_92079165_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478931 | chr9_92079173_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478932 | chr9_92079181_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478933 | chr9_92079184_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478934 | chr9_92079204_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478935 | chr9_92079208_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478936 | chr9_92079213_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478937 | chr9_92079214_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478938 | chr9_92079220_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478939 | chr9_92079222_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478940 | chr9_92079240_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478941 | chr9_92079255_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478942 | chr9_92079258_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478943 | chr9_92079269_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478944 | chr9_92079270_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478945 | chr9_92079277_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478946 | chr9_92079303_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478947 | chr9_92079318_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478948 | chr9_92079322_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478949 | chr9_92079326_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478950 | chr9_92079332_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478951 | chr9_92079333_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478952 | chr9_92079348_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478953 | chr9_92079349_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478954 | chr9_92079367_- | SINE | Alu | Name=AluSx1 |
| ADediting_1478956 | chr9_92107588_- | SINE | Alu | Name=AluY |
| ADediting_1478957 | chr9_92107628_- | SINE | Alu | Name=AluY |
| ADediting_1594282 | chr9_92032624_- | SINE | Alu | Name=AluY |
| ADediting_1594283 | chr9_92032695_- | SINE | Alu | Name=AluY |
| ADediting_1594284 | chr9_92033677_- | SINE | Alu | Name=AluJb |
| ADediting_1594285 | chr9_92033740_- | SINE | Alu | Name=AluJb |
| ADediting_1594286 | chr9_92033742_- | SINE | Alu | Name=AluJb |
| ADediting_1594287 | chr9_92033801_- | SINE | Alu | Name=AluJb |
| ADediting_1594288 | chr9_92033827_- | SINE | Alu | Name=AluJb |
| ADediting_1594289 | chr9_92055164_- | SINE | Alu | Name=AluJo |
| ADediting_1594290 | chr9_92078597_- | SINE | Alu | Name=AluJb |
| ADediting_1594291 | chr9_92078721_- | SINE | Alu | Name=AluJb |
| ADediting_1594292 | chr9_92078728_- | SINE | Alu | Name=AluJb |
| ADediting_1594293 | chr9_92079197_- | SINE | Alu | Name=AluSx1 |
Top |
RNA A-to-I editing events in the alternative splicing sites for SPTLC1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| ES | ADediting_1478884 | chr9_92033841_- | 92033834:92033842 | 5ss | 2e | CAGGTGCAG | 4.95 | CGGGTGCAG | -0.19 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for SPTLC1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for SPTLC1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for SPTLC1 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1478928 | chr9_92079148_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-324-3p | chr9 | 92079148 | 92079154 | 7mer-m8 | 92079147 | 92079169 | 149 | -24.32 |
| ADediting_1478928 | chr9_92079148_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-6075 | chr9 | 92079143 | 92079150 | 8mer-1a | 92079143 | 92079164 | 150 | -25.48 |
| ADediting_1478929 | chr9_92079161_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-1281 | chr9 | 92079161 | 92079167 | 7mer-m8 | 92079160 | 92079176 | 141 | -17.01 |
| ADediting_1478930 | chr9_92079165_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-1913 | chr9 | 92079159 | 92079166 | 8mer-1a | 92079159 | 92079180 | 156 | -24.01 |
| ADediting_1478930 | chr9_92079165_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-361-3p | chr9 | 92079164 | 92079170 | 7mer-m8 | 92079163 | 92079189 | 161 | -27.12 |
| ADediting_1478933 | chr9_92079184_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-3679-3p | chr9 | 92079181 | 92079187 | 7mer-m8 | 92079180 | 92079201 | 151 | -22.62 |
| ADediting_1478934 | chr9_92079204_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-1207-3p | chr9 | 92079204 | 92079210 | 7mer-m8 | 92079203 | 92079220 | 140 | -12.56 |
| ADediting_1478937 | chr9_92079214_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-513a-5p | chr9 | 92079213 | 92079219 | 7mer-m8 | 92079212 | 92079229 | 144 | -14.96 |
| ADediting_1478937 | chr9_92079214_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-638 | chr9 | 92079208 | 92079214 | 7mer-1a | 92079208 | 92079232 | 140 | -26.83 |
| ADediting_1478941 | chr9_92079255_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-222-5p | chr9 | 92079253 | 92079260 | 8mer-1a | 92079253 | 92079274 | 140 | -9.84 |
| ADediting_1478941 | chr9_92079255_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-30a-3p | chr9 | 92079251 | 92079258 | 8mer-1a | 92079251 | 92079275 | 150 | -16.9 |
| ADediting_1478941 | chr9_92079255_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-30d-3p | chr9 | 92079251 | 92079258 | 8mer-1a | 92079251 | 92079273 | 149 | -12.58 |
| ADediting_1478941 | chr9_92079255_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-30e-3p | chr9 | 92079251 | 92079258 | 8mer-1a | 92079251 | 92079275 | 150 | -15.85 |
| ADediting_1478942 | chr9_92079258_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-374b-3p | chr9 | 92079253 | 92079260 | 8mer-1a | 92079253 | 92079275 | 147 | -11.32 |
| ADediting_1478943 | chr9_92079269_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-3188 | chr9 | 92079265 | 92079271 | 7mer-m8 | 92079264 | 92079285 | 144 | -17.05 |
| ADediting_1478945 | chr9_92079277_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-1306-3p | chr9 | 92079277 | 92079283 | 7mer-m8 | 92079276 | 92079293 | 152 | -23.7 |
| ADediting_1478947 | chr9_92079318_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-4485-5p | chr9 | 92079316 | 92079323 | 8mer-1a | 92079316 | 92079332 | 157 | -26.74 |
| ADediting_1478948 | chr9_92079322_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-4707-3p | chr9 | 92079318 | 92079325 | 8mer-1a | 92079318 | 92079339 | 162 | -26.96 |
| ADediting_1478949 | chr9_92079326_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-1913 | chr9 | 92079321 | 92079327 | 7mer-m8 | 92079320 | 92079341 | 148 | -22.76 |
| ADediting_1478949 | chr9_92079326_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-6849-3p | chr9 | 92079326 | 92079332 | 7mer-m8 | 92079325 | 92079346 | 147 | -14.69 |
| ADediting_1478950 | chr9_92079332_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-129-1-3p | chr9 | 92079328 | 92079334 | 7mer-m8 | 92079327 | 92079348 | 140 | -11.04 |
| ADediting_1478950 | chr9_92079332_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-129-2-3p | chr9 | 92079328 | 92079334 | 7mer-m8 | 92079327 | 92079348 | 140 | -10.59 |
| ADediting_1478950 | chr9_92079332_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-4780 | chr9 | 92079330 | 92079336 | 7mer-m8 | 92079329 | 92079350 | 147 | -14.8 |
| ADediting_1478951 | chr9_92079333_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-146a-3p | chr9 | 92079331 | 92079337 | 7mer-m8 | 92079330 | 92079351 | 147 | -14.9 |
| ADediting_1478951 | chr9_92079333_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-4766-5p | chr9 | 92079332 | 92079339 | 8mer-1a | 92079332 | 92079352 | 149 | -16.71 |
| ADediting_1478951 | chr9_92079333_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-6819-3p | chr9 | 92079328 | 92079334 | 7mer-m8 | 92079327 | 92079347 | 145 | -14.15 |
| ADediting_1478951 | chr9_92079333_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-6877-3p | chr9 | 92079328 | 92079334 | 7mer-m8 | 92079327 | 92079347 | 145 | -21.47 |
| ADediting_1478952 | chr9_92079348_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-8052 | chr9 | 92079343 | 92079349 | 7mer-1a | 92079343 | 92079361 | 148 | -29.06 |
| ADediting_1478953 | chr9_92079349_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-513a-5p | chr9 | 92079348 | 92079354 | 7mer-m8 | 92079347 | 92079364 | 152 | -17.32 |
| ADediting_1478953 | chr9_92079349_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-638 | chr9 | 92079343 | 92079349 | 7mer-1a | 92079343 | 92079367 | 155 | -34.38 |
| ADediting_1594293 | chr9_92079197_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-3943 | chr9 | 92079193 | 92079199 | 7mer-m8 | 92079192 | 92079213 | 147 | -22.28 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1478928 | chr9_92079148_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-4284 | chr9 | 92079145 | 92079151 | 7mer-m8 | 92079144 | 92079161 | 151 | -15.7 |
| ADediting_1478929 | chr9_92079161_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-6836-3p | chr9 | 92079161 | 92079167 | 7mer-m8 | 92079160 | 92079180 | 145 | -20.12 |
| ADediting_1478930 | chr9_92079165_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-6778-3p | chr9 | 92079161 | 92079168 | 8mer-1a | 92079161 | 92079181 | 142 | -17.51 |
| ADediting_1478930 | chr9_92079165_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-6836-3p | chr9 | 92079161 | 92079167 | 7mer-m8 | 92079160 | 92079180 | 145 | -20.12 |
| ADediting_1478932 | chr9_92079181_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-5571-5p | chr9 | 92079179 | 92079185 | 7mer-m8 | 92079178 | 92079200 | 150 | -27.21 |
| ADediting_1478933 | chr9_92079184_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-532-3p | chr9 | 92079182 | 92079189 | 8mer-1a | 92079182 | 92079201 | 147 | -20.13 |
| ADediting_1478933 | chr9_92079184_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-5571-5p | chr9 | 92079179 | 92079185 | 7mer-m8 | 92079178 | 92079200 | 150 | -27.21 |
| ADediting_1478935 | chr9_92079208_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-5089-5p | chr9 | 92079208 | 92079214 | 7mer-m8 | 92079207 | 92079226 | 152 | -13.68 |
| ADediting_1478935 | chr9_92079208_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-6506-5p | chr9 | 92079207 | 92079213 | 7mer-m8 | 92079206 | 92079228 | 144 | -15.79 |
| ADediting_1478936 | chr9_92079213_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-10399-5p | chr9 | 92079212 | 92079218 | 7mer-m8 | 92079211 | 92079230 | 145 | -10.21 |
| ADediting_1478936 | chr9_92079213_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-5089-5p | chr9 | 92079208 | 92079214 | 7mer-m8 | 92079207 | 92079226 | 152 | -13.68 |
| ADediting_1478936 | chr9_92079213_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-6504-3p | chr9 | 92079212 | 92079218 | 7mer-m8 | 92079211 | 92079229 | 144 | -11.57 |
| ADediting_1478937 | chr9_92079214_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-10399-5p | chr9 | 92079212 | 92079218 | 7mer-m8 | 92079211 | 92079230 | 145 | -10.21 |
| ADediting_1478937 | chr9_92079214_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-6504-3p | chr9 | 92079212 | 92079218 | 7mer-m8 | 92079211 | 92079229 | 144 | -11.57 |
| ADediting_1478940 | chr9_92079240_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-4735-5p | chr9 | 92079239 | 92079245 | 7mer-m8 | 92079238 | 92079259 | 140 | -5.48 |
| ADediting_1478942 | chr9_92079258_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-6832-5p | chr9 | 92079257 | 92079263 | 7mer-m8 | 92079256 | 92079278 | 151 | -18.4 |
| ADediting_1478945 | chr9_92079277_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-4781-3p | chr9 | 92079276 | 92079282 | 7mer-m8 | 92079275 | 92079293 | 144 | -13.86 |
| ADediting_1478947 | chr9_92079318_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-5001-3p | chr9 | 92079316 | 92079322 | 7mer-m8 | 92079315 | 92079335 | 146 | -20.82 |
| ADediting_1478947 | chr9_92079318_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-6894-3p | chr9 | 92079318 | 92079324 | 7mer-m8 | 92079317 | 92079336 | 155 | -23.54 |
| ADediting_1478948 | chr9_92079322_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-6747-3p | chr9 | 92079320 | 92079326 | 7mer-m8 | 92079319 | 92079341 | 152 | -18.45 |
| ADediting_1478948 | chr9_92079322_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-6894-3p | chr9 | 92079318 | 92079324 | 7mer-m8 | 92079317 | 92079336 | 155 | -23.54 |
| ADediting_1478952 | chr9_92079348_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-10399-5p | chr9 | 92079347 | 92079353 | 7mer-m8 | 92079346 | 92079367 | 144 | -10.26 |
| ADediting_1478952 | chr9_92079348_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-5089-5p | chr9 | 92079343 | 92079349 | 7mer-m8 | 92079342 | 92079361 | 146 | -13.24 |
| ADediting_1478953 | chr9_92079349_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-10399-5p | chr9 | 92079347 | 92079353 | 7mer-m8 | 92079346 | 92079367 | 144 | -10.26 |
| ADediting_1478953 | chr9_92079349_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-7151-3p | chr9 | 92079348 | 92079355 | 8mer-1a | 92079348 | 92079364 | 146 | -17.62 |
| ADediting_1478954 | chr9_92079367_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-6872-3p | chr9 | 92079364 | 92079370 | 7mer-m8 | 92079363 | 92079385 | 144 | -19.72 |
| ADediting_1594293 | chr9_92079197_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-532-3p | chr9 | 92079196 | 92079202 | 7mer-m8 | 92079195 | 92079216 | 140 | -20.38 |
| ADediting_1594293 | chr9_92079197_- | ENSG00000090054.15 | ENST00000337841.4 | SPTLC1-202 | hsa-miR-6778-3p | chr9 | 92079194 | 92079200 | 7mer-m8 | 92079193 | 92079213 | 140 | -16.13 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_286380 | chr11_79422188_- | ENSG00000090054.15 | ENST00000262554.7 | SPTLC1-201 | hsa-miR-5579-3p | chr9 | 92031573 | 92031580 | 8mer-1a | 92031573 | 92031594 | 147 | -15.01 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000090054.15 | ENST00000262554.7 | SPTLC1-201 | hsa-miR-5688 | chr9 | 92031185 | 92031191 | 7mer-m8 | 92031184 | 92031205 | 140 | -9.57 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000090054.15 | ENST00000262554.7 | SPTLC1-201 | hsa-miR-5688 | chr9 | 92031432 | 92031439 | 8mer-1a | 92031432 | 92031451 | 153 | -12.48 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000090054.15 | ENST00000262554.7 | SPTLC1-201 | hsa-miR-4477b | chr9 | 92032078 | 92032084 | 7mer-m8 | 92032077 | 92032100 | 143 | -9.88 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000090054.15 | ENST00000262554.7 | SPTLC1-201 | hsa-miR-4477b | chr9 | 92032078 | 92032084 | 7mer-m8 | 92032077 | 92032100 | 143 | -9.88 |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for SPTLC1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000337841.4 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1478928 | ENST00000337841.4 | chr9_92079148_- | 859 | -288.40 | -286.90 | -309.30 |
| ADediting_1478929 | ENST00000337841.4 | chr9_92079161_- | 846 | -288.24 | -286.90 | -309.30 |
| ADediting_1478930 | ENST00000337841.4 | chr9_92079165_- | 842 | -287.70 | -286.90 | -309.30 |
| ADediting_1478931 | ENST00000337841.4 | chr9_92079173_- | 834 | -289.10 | -286.90 | -309.30 |
| ADediting_1478932 | ENST00000337841.4 | chr9_92079181_- | 826 | -291.10 | -286.90 | -309.30 |
| ADediting_1478933 | ENST00000337841.4 | chr9_92079184_- | 823 | -286.50 | -286.90 | -309.30 |
| ADediting_1594293 | ENST00000337841.4 | chr9_92079197_- | 810 | -286.50 | -286.90 | -309.30 |
| ADediting_1478934 | ENST00000337841.4 | chr9_92079204_- | 803 | -286.60 | -286.90 | -309.30 |
| ADediting_1478935 | ENST00000337841.4 | chr9_92079208_- | 799 | -289.10 | -286.90 | -309.30 |
| ADediting_1478936 | ENST00000337841.4 | chr9_92079213_- | 794 | -288.50 | -286.90 | -309.30 |
| ADediting_1478937 | ENST00000337841.4 | chr9_92079214_- | 793 | -286.90 | -286.90 | -309.30 |
| ADediting_1478938 | ENST00000337841.4 | chr9_92079220_- | 787 | -288.60 | -286.90 | -309.30 |
| ADediting_1478939 | ENST00000337841.4 | chr9_92079222_- | 785 | -287.00 | -286.90 | -309.30 |
| ADediting_1478940 | ENST00000337841.4 | chr9_92079240_- | 767 | -291.30 | -286.90 | -309.30 |
| ADediting_1478941 | ENST00000337841.4 | chr9_92079255_- | 752 | -286.90 | -286.90 | -309.30 |
| ADediting_1478942 | ENST00000337841.4 | chr9_92079258_- | 749 | -288.40 | -286.90 | -309.30 |
| ADediting_1478943 | ENST00000337841.4 | chr9_92079269_- | 738 | -286.60 | -286.90 | -309.30 |
| ADediting_1478944 | ENST00000337841.4 | chr9_92079270_- | 737 | -290.30 | -286.90 | -309.30 |
| ADediting_1478945 | ENST00000337841.4 | chr9_92079277_- | 730 | -286.50 | -286.90 | -309.30 |
| ADediting_1478946 | ENST00000337841.4 | chr9_92079303_- | 704 | -286.20 | -286.90 | -309.30 |
| ADediting_1478947 | ENST00000337841.4 | chr9_92079318_- | 689 | -286.20 | -286.90 | -309.30 |
| ADediting_1478948 | ENST00000337841.4 | chr9_92079322_- | 685 | -286.20 | -286.90 | -309.30 |
| ADediting_1478949 | ENST00000337841.4 | chr9_92079326_- | 681 | -293.10 | -286.90 | -309.30 |
| ADediting_1478950 | ENST00000337841.4 | chr9_92079332_- | 675 | -286.60 | -286.90 | -309.30 |
| ADediting_1478951 | ENST00000337841.4 | chr9_92079333_- | 674 | -287.30 | -286.90 | -309.30 |
| ADediting_1478952 | ENST00000337841.4 | chr9_92079348_- | 659 | -286.90 | -286.90 | -309.30 |
| ADediting_1478953 | ENST00000337841.4 | chr9_92079349_- | 658 | -286.90 | -286.90 | -309.30 |
| ADediting_1478954 | ENST00000337841.4 | chr9_92079367_- | 640 | -287.40 | -286.90 | -309.30 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for SPTLC1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1478853 | chr9_92032621_- | 0.00161190092132627 | 0.255355485038236 | 5.27317641098283e-08 | 0.426485281033556 | 3.76326414053837e-05 | 0.329816904051137 |
| CER | ADediting_1478854 | chr9_92032633_- | 0.000516226482260605 | 0.280148159359275 | 2.00688855493779e-07 | 0.409163556078946 | 0.00595884588135831 | 0.223560590556866 |
| CER | ADediting_1478855 | chr9_92032634_- | 0.00151793035335573 | 0.256723932719065 | 6.88966408764141e-08 | 0.423096892384125 | 0.00149461388999437 | 0.257075423099709 |
| DLPFC | ADediting_1478856 | chr9_92032651_- | 2.66241391220363e-06 | 0.263026293707863 | 0.00237177284214135 | 0.17202348750278 | 5.01591181571883e-08 | 0.303476065341565 |
| CER | ADediting_1478856 | chr9_92032651_- | 0.000953281479480107 | 0.26708403718831 | 2.93707458410886e-10 | 0.485838889728851 | 0.0038883664947341 | 0.234396685050711 |
| CER | ADediting_1478857 | chr9_92032683_- | 0.00818495640048584 | 0.215174577872118 | 2.93634551129839e-09 | 0.460898977445935 | 0.00220918890017624 | 0.248051726668804 |
| CER | ADediting_1478858 | chr9_92032687_- | 0.0250675040176815 | 0.182908783441718 | 3.09754951020402e-07 | 0.403321871448122 | 0.00163643360283327 | 0.255010207705024 |
| DLPFC | ADediting_1478859 | chr9_92032752_- | 6.15269615389057e-06 | 0.253594409724193 | 0.0251574911920256 | 0.127162325974365 | 7.67132419071068e-18 | 0.462567493996434 |
| CER | ADediting_1478859 | chr9_92032752_- | 0.000123981711186253 | 0.308291735499469 | 2.81534284539538e-09 | 0.461373260023077 | 0.00159680444262932 | 0.255570342697606 |
| CER | ADediting_1478861 | chr9_92032764_- | 0.000140035547420972 | 0.305998231501562 | 1.85324601524808e-10 | 0.490595189312946 | 0.000145533018405397 | 0.305268986843619 |
| DLPFC | ADediting_1478862 | chr9_92032767_- | 0.00161649223784089 | 0.178356064357644 | 0.275490197904742 | 0.0621277245346392 | 8.26280646720928e-12 | 0.375371550801157 |
| CER | ADediting_1478862 | chr9_92032767_- | 0.000231091411352512 | 0.296358951300043 | 2.66482517655693e-08 | 0.43496920806806 | 0.0136764306887407 | 0.200942747187651 |
| DLPFC | ADediting_1478863 | chr9_92032837_- | 4.34932658237253e-09 | 0.325598577949545 | 7.50781144366065e-05 | 0.222953242960829 | 3.98627934184522e-05 | 0.231101548406152 |
| CER | ADediting_1478864 | chr9_92033618_- | 0.00371608478790879 | 0.235519325769094 | 1.1995075318183e-08 | 0.444605626647401 | 0.0118869779474629 | 0.204918094002568 |
| CER | ADediting_1478867 | chr9_92033684_- | 1.34896413977726e-05 | 0.347130446514634 | 2.90971972948977e-13 | 0.550537872762533 | 0.000365663911506642 | 0.287221932639387 |
| CER | ADediting_1478868 | chr9_92033688_- | 0.00119732682193241 | 0.262059332532509 | 6.11801368429655e-08 | 0.424606738821588 | 0.00325433919442905 | 0.238777104461857 |
| CER | ADediting_1478871 | chr9_92033750_- | 0.0044436084377438 | 0.231060020133158 | 2.52393304389856e-06 | 0.373391396217033 | 0.0720060272312843 | 0.147324085699693 |
| CER | ADediting_1478872 | chr9_92033760_- | 4.93262841705236e-05 | 0.32507247689653 | 5.99150415707862e-11 | 0.501958413520188 | 0.0116848199746304 | 0.205399655723946 |
| DLPFC | ADediting_1478873 | chr9_92033763_- | 4.86497334941939e-05 | 0.228569308555413 | 0.0191696888153397 | 0.132974751128969 | 3.41951489637072e-13 | 0.397724296720515 |
| CER | ADediting_1478873 | chr9_92033763_- | 0.00424197691362891 | 0.232226018322462 | 5.41531280030246e-06 | 0.361717353151739 | 0.237996222173842 | 0.0969312309150874 |
| DLPFC | ADediting_1478874 | chr9_92033765_- | 6.95181118789135e-06 | 0.252188213503198 | 0.00142198940792532 | 0.180427967005256 | 8.23961991167164e-10 | 0.33969019703608 |
| CER | ADediting_1478874 | chr9_92033765_- | 6.94355006049259e-05 | 0.318962119518987 | 1.37179783852397e-10 | 0.493663387095115 | 0.00631302942872006 | 0.22205696279378 |
| DLPFC | ADediting_1478875 | chr9_92033766_- | 1.69974448047177e-05 | 0.241631207988336 | 0.00507071802304936 | 0.158801944289109 | 3.94415121372737e-10 | 0.345710465122224 |
| CER | ADediting_1478875 | chr9_92033766_- | 4.75257401062628e-05 | 0.325729156764917 | 7.81425018488418e-11 | 0.499322860049261 | 0.0369282734917511 | 0.170543118727606 |
| CER | ADediting_1478876 | chr9_92033768_- | 0.000712606744857281 | 0.273361891621826 | 1.27744043937649e-08 | 0.443856491068669 | 0.0118914769392343 | 0.204907458945386 |
| DLPFC | ADediting_1478879 | chr9_92033789_- | 5.77931505487578e-07 | 0.279349727401268 | 0.000463894328726825 | 0.197664319580199 | 4.18888621633621e-09 | 0.325924986696122 |
| CER | ADediting_1478879 | chr9_92033789_- | 0.000700143636685591 | 0.273737811944854 | 2.51522614322592e-11 | 0.510417522937743 | 0.00445377812255805 | 0.231002477070387 |
| CER | ADediting_1478881 | chr9_92033812_- | 2.21183984905982e-05 | 0.338914258628406 | 2.56555428669749e-11 | 0.510227008253851 | 0.0107133013978944 | 0.207821336769158 |
| DLPFC | ADediting_1478883 | chr9_92033825_- | 8.87826106580227e-08 | 0.298036257752264 | 0.000219877110762209 | 0.20839570707579 | 4.95699297466677e-08 | 0.303587464105401 |
| CER | ADediting_1478883 | chr9_92033825_- | 0.000360955590687757 | 0.28748421175727 | 2.0399301810831e-09 | 0.464980475279471 | 0.0442593696139948 | 0.16450400037435 |
| CER | ADediting_1594285 | chr9_92033740_- | 0.0006016243151699 | 0.276947129613142 | 7.57236182969683e-08 | 0.421890648748921 | 0.00720650743590809 | 0.218573707461395 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 7.02608206000462e-56 | 0.744022443278542 | 8.83943254754904e-38 | 0.644488058892408 | 0.00293820607404973 | 0.168391651348309 |
| AC | 1.20267677001764e-82 | 0.881166430053641 | 9.75252791505239e-48 | 0.757008639809066 | 2.40764655774512e-18 | 0.515122258926115 |
| PCC | 4.80553589643674e-32 | 0.721904771276177 | 4.27197003441412e-29 | 0.696894158403447 | 0.000523742381535596 | 0.248637562426245 |
| CER | 1.18698167165446e-39 | 0.831710521641544 | 6.05490014373743e-24 | 0.706070784082707 | 9.34160693444689e-08 | 0.419192946300481 |
| TCX | 8.66501875134378e-32 | 0.778866731028296 | 3.09909597989181e-05 | 0.333174000421693 | 5.2990426380817e-10 | 0.479634936406007 |
| FP | 3.69050737743605e-29 | 0.714968530006475 | 8.5447810518916e-29 | 0.711701668488845 | 0.010306628471922 | 0.191844665787401 |
| IFG | 1.41484221704308e-05 | 0.752771490023024 | 0.00165057925874538 | 0.596434771699491 | 0.0832664573397495 | 0.353224716084168 |
| PG | 1.13981133499932e-56 | 0.863785074315219 | 3.95414345736642e-26 | 0.675425563032449 | 0.450094382581043 | 0.0557107166178613 |
| STG | 5.25660044573477e-23 | 0.835253248729546 | 1.70386938940538e-10 | 0.627381738988812 | 0.0760380871992013 | 0.194636356855455 |
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Relation with AD stages for SPTLC1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_1478853 | chr9_92032621_- | 2.40261344284151e-05 | 0.394417425580923 |
| CER | ADediting_1478854 | chr9_92032633_- | 0.000354345983507228 | 0.33749533607256 |
| CER | ADediting_1478855 | chr9_92032634_- | 1.88926663182037e-05 | 0.399023447354843 |
| CER | ADediting_1478857 | chr9_92032683_- | 0.000307843114805188 | 0.340751485414524 |
| CER | ADediting_1478858 | chr9_92032687_- | 9.55518316027216e-05 | 0.366544732095394 |
| CER | ADediting_1478859 | chr9_92032752_- | 0.00028473028247517 | 0.342542720677015 |
| CER | ADediting_1478861 | chr9_92032764_- | 7.17700979893235e-05 | 0.372534461878624 |
| CER | ADediting_1478864 | chr9_92033618_- | 9.12171726603315e-07 | 0.451932535176506 |
| CER | ADediting_1478867 | chr9_92033684_- | 5.82496407451633e-09 | 0.524145654878003 |
| CER | ADediting_1478868 | chr9_92033688_- | 0.00103613510241202 | 0.311404909691311 |
| CER | ADediting_1478872 | chr9_92033760_- | 0.000190734337627267 | 0.351573274443448 |
| CER | ADediting_1478874 | chr9_92033765_- | 0.0010672455400489 | 0.310651510988395 |
| CER | ADediting_1478881 | chr9_92033812_- | 1.24453310694692e-05 | 0.406863772272941 |
| CER | ADediting_1594285 | chr9_92033740_- | 0.000677304185372573 | 0.322021380263548 |
| TCX | ADediting_1478864 | chr9_92033618_- | 0.000111613774438251 | 0.366490778700508 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 5.40813338640791e-06 | 0.421952329963818 |
| TCX | 3.47399210400058e-06 | 0.433397149661442 |
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RelatedDrugs for SPTLC1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| SPTLC1 | O15269 | DB00114 | Pyridoxal phosphate | Serine palmitoyltransferase 1 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for SPTLC1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| SPTLC1 | C0020071 | Hereditary Sensory Autonomic Neuropathy, Type 1 | 6 | CTD_human;ORPHANET;UNIPROT |
| SPTLC1 | C0013364 | Dysautonomia, Familial | 3 | GENOMICS_ENGLAND |
| SPTLC1 | C0391976 | Pain Disorder | 3 | GENOMICS_ENGLAND |
| SPTLC1 | C0006142 | Malignant neoplasm of breast | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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