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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

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Relation with AD stages

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Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for RPP30

check button Gene summary
Gene informationGene symbol

RPP30

Gene ID

10556

Gene nameribonuclease P/MRP subunit p30
SynonymsTSG15
Cytomap

10q23.31

Type of geneprotein-coding
Descriptionribonuclease P protein subunit p30RNase P subunit 2RNaseP protein p30ribonuclease P/MRP 30kDa subunit
Modification date20200313
UniProtAcc

P78346,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
RPP30

GO:0001682

tRNA 5'-leader removal

16723659|30454648


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RNA A-to-I events for RPP30

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_222668(90901030, +), ADediting_222669(90901038, +), ADediting_222670(90901041, +), ADediting_222671(90901075, +), ADediting_222672(90901104, +), ADediting_222673(90901114, +), ADediting_222674(90901184, +), ADediting_222675(90901207, +), ADediting_222676(90901222, +), ADediting_222677(90901226, +), ADediting_222678(90901247, +), ADediting_222679(90901982, +), ADediting_222680(90901996, +), ADediting_222681(90902004, +), ADediting_222682(90902019, +), ADediting_222683(90902040, +), ADediting_222684(90902057, +), ADediting_222685(90902257, +), ADediting_222686(90902279, +), ADediting_222687(90902281, +), ADediting_222688(90902282, +), ADediting_222689(90902292, +), ADediting_222690(90902298, +), ADediting_222691(90902317, +), ADediting_222692(90902318, +), ADediting_222693(90902330, +), ADediting_222694(90902380, +), ADediting_222695(90902384, +), ADediting_222696(90902385, +), ADediting_222697(90902393, +), ADediting_222698(90902431, +), ADediting_222699(90902437, +), ADediting_222700(90902472, +), ADediting_222701(90902480, +), ADediting_222702(90902481, +), ADediting_222703(90904551, +), ADediting_222704(90904557, +), ADediting_222705(90904558, +), ADediting_222706(90904571, +), ADediting_222707(90904579, +), ADediting_222708(90904580, +), ADediting_222709(90904592, +), ADediting_222710(90904593, +), ADediting_222711(90904598, +), ADediting_222712(90904603, +), ADediting_222713(90904611, +), ADediting_222714(90904612, +), ADediting_222715(90904617, +), ADediting_222716(90904626, +), ADediting_222717(90904627, +), ADediting_222718(90904629, +), ADediting_222719(90904634, +), ADediting_222720(90904635, +), ADediting_222721(90904637, +), ADediting_222722(90904655, +), ADediting_222723(90904657, +), ADediting_222724(90904660, +), ADediting_222725(90904661, +), ADediting_222726(90904665, +), ADediting_222727(90904669, +), ADediting_222728(90904686, +), ADediting_222729(90904691, +), ADediting_222730(90904692, +), ADediting_222731(90904701, +), ADediting_222732(90904718, +), ADediting_222733(90904722, +), ADediting_222734(90904723, +), ADediting_222735(90904732, +), ADediting_222736(90904733, +), ADediting_222737(90904744, +), ADediting_222738(90904762, +), ADediting_222739(90904769, +), ADediting_222740(90904797, +), ADediting_1524879(90904662, +), ADediting_1524880(90904724, +),

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RNA editing positional annotations for RPP30 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
ADediting_222685chr10_90902257_+nonsynonymous SNVENST00000413330.5c.A811Gp.T271A0.0610.0-0.15
ADediting_222686chr10_90902279_+nonsynonymous SNVENST00000413330.5c.A833Gp.H278R0.0230.5370.1
ADediting_222687chr10_90902281_+nonsynonymous SNVENST00000413330.5c.A835Gp.N279D0.00.6210.01
ADediting_222688chr10_90902282_+nonsynonymous SNVENST00000413330.5c.A836Gp.N279S0.00.6210.09
ADediting_222689chr10_90902292_+synonymous SNVENST00000413330.5c.A846Gp.S282S...
ADediting_222690chr10_90902298_+synonymous SNVENST00000413330.5c.A852Gp.Q284Q...
ADediting_222691chr10_90902317_+nonsynonymous SNVENST00000413330.5c.A871Gp.K291E0.00.621-0.18
ADediting_222692chr10_90902318_+nonsynonymous SNVENST00000413330.5c.A872Gp.K291R0.00.621-0.14
ADediting_222693chr10_90902330_+nonsynonymous SNVENST00000413330.5c.A884Gp.H295R0.00.00.63

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_222668chr10_90901030_+UTR3
ADediting_222669chr10_90901038_+UTR3
ADediting_222670chr10_90901041_+UTR3
ADediting_222671chr10_90901075_+UTR3
ADediting_222672chr10_90901104_+UTR3
ADediting_222673chr10_90901114_+UTR3
ADediting_222674chr10_90901184_+UTR3
ADediting_222675chr10_90901207_+UTR3
ADediting_222676chr10_90901222_+UTR3
ADediting_222677chr10_90901226_+UTR3
ADediting_222678chr10_90901247_+UTR3
ADediting_222679chr10_90901982_+UTR3
ADediting_222680chr10_90901996_+UTR3
ADediting_222681chr10_90902004_+UTR3
ADediting_222682chr10_90902019_+UTR3
ADediting_222683chr10_90902040_+UTR3
ADediting_222684chr10_90902057_+UTR3
ADediting_222685chr10_90902257_+exonic
ADediting_222686chr10_90902279_+exonic
ADediting_222687chr10_90902281_+exonic
ADediting_222688chr10_90902282_+exonic
ADediting_222689chr10_90902292_+exonic
ADediting_222690chr10_90902298_+exonic
ADediting_222691chr10_90902317_+exonic
ADediting_222692chr10_90902318_+exonic
ADediting_222693chr10_90902330_+exonic
ADediting_222694chr10_90902380_+intronic
ADediting_222695chr10_90902384_+intronic
ADediting_222696chr10_90902385_+intronic
ADediting_222697chr10_90902393_+intronic
ADediting_222698chr10_90902431_+intronic
ADediting_222699chr10_90902437_+intronic
ADediting_222700chr10_90902472_+intronic
ADediting_222701chr10_90902480_+intronic
ADediting_222702chr10_90902481_+intronic
ADediting_222703chr10_90904551_+intergenic
ADediting_222704chr10_90904557_+intergenic
ADediting_222705chr10_90904558_+intergenic
ADediting_222706chr10_90904571_+intergenic
ADediting_222707chr10_90904579_+intergenic
ADediting_222708chr10_90904580_+intergenic
ADediting_222709chr10_90904592_+intergenic
ADediting_222710chr10_90904593_+intergenic
ADediting_222711chr10_90904598_+intergenic
ADediting_222712chr10_90904603_+intergenic
ADediting_222713chr10_90904611_+intergenic
ADediting_222714chr10_90904612_+intergenic
ADediting_222715chr10_90904617_+intergenic
ADediting_222716chr10_90904626_+intergenic
ADediting_222717chr10_90904627_+intergenic
ADediting_222718chr10_90904629_+intergenic
ADediting_222719chr10_90904634_+intergenic
ADediting_222720chr10_90904635_+intergenic
ADediting_222721chr10_90904637_+intergenic
ADediting_222722chr10_90904655_+intergenic
ADediting_222723chr10_90904657_+intergenic
ADediting_222724chr10_90904660_+intergenic
ADediting_222725chr10_90904661_+intergenic
ADediting_222726chr10_90904665_+intergenic
ADediting_222727chr10_90904669_+intergenic
ADediting_222728chr10_90904686_+intergenic
ADediting_222729chr10_90904691_+intergenic
ADediting_222730chr10_90904692_+intergenic
ADediting_222731chr10_90904701_+intergenic
ADediting_222732chr10_90904718_+intergenic
ADediting_222733chr10_90904722_+intergenic
ADediting_222734chr10_90904723_+intergenic
ADediting_222735chr10_90904732_+intergenic
ADediting_222736chr10_90904733_+intergenic
ADediting_222737chr10_90904744_+intergenic
ADediting_222738chr10_90904762_+intergenic
ADediting_222739chr10_90904769_+intergenic
ADediting_222740chr10_90904797_+intergenic
ADediting_1524879chr10_90904662_+intergenic
ADediting_1524880chr10_90904724_+intergenic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_222668chr10_90901030_+SINEAluName=AluJo
ADediting_222669chr10_90901038_+SINEAluName=AluJo
ADediting_222670chr10_90901041_+SINEAluName=AluJo
ADediting_222671chr10_90901075_+SINEAluName=AluJo
ADediting_222672chr10_90901104_+SINEAluName=AluJo
ADediting_222673chr10_90901114_+SINEAluName=AluJo
ADediting_222674chr10_90901184_+SINEAluName=AluJo
ADediting_222675chr10_90901207_+SINEAluName=AluJo
ADediting_222676chr10_90901222_+SINEAluName=AluJo
ADediting_222677chr10_90901226_+SINEAluName=AluJo
ADediting_222678chr10_90901247_+SINEAluName=AluJo
ADediting_222679chr10_90901982_+SINEAluName=AluY
ADediting_222680chr10_90901996_+SINEAluName=AluY
ADediting_222681chr10_90902004_+SINEAluName=AluY
ADediting_222682chr10_90902019_+SINEAluName=AluY
ADediting_222683chr10_90902040_+SINEAluName=AluY
ADediting_222684chr10_90902057_+SINEAluName=AluY
ADediting_222685chr10_90902257_+SINEAluName=AluSz6
ADediting_222686chr10_90902279_+SINEAluName=AluSz6
ADediting_222687chr10_90902281_+SINEAluName=AluSz6
ADediting_222688chr10_90902282_+SINEAluName=AluSz6
ADediting_222689chr10_90902292_+SINEAluName=AluSz6
ADediting_222690chr10_90902298_+SINEAluName=AluSz6
ADediting_222691chr10_90902317_+SINEAluName=AluSz6
ADediting_222692chr10_90902318_+SINEAluName=AluSz6
ADediting_222693chr10_90902330_+SINEAluName=AluSz6
ADediting_222694chr10_90902380_+SINEAluName=AluSz6
ADediting_222695chr10_90902384_+SINEAluName=AluSz6
ADediting_222696chr10_90902385_+SINEAluName=AluSz6
ADediting_222697chr10_90902393_+SINEAluName=AluSz6
ADediting_222698chr10_90902431_+SINEAluName=AluSz6
ADediting_222699chr10_90902437_+SINEAluName=AluSz6
ADediting_222700chr10_90902472_+SINEAluName=AluSz6
ADediting_222701chr10_90902480_+SINEAluName=AluSz6
ADediting_222702chr10_90902481_+SINEAluName=AluSz6
ADediting_222703chr10_90904551_+SINEAluName=AluSz6
ADediting_222704chr10_90904557_+SINEAluName=AluSz6
ADediting_222705chr10_90904558_+SINEAluName=AluSz6
ADediting_222706chr10_90904571_+SINEAluName=AluSz6
ADediting_222707chr10_90904579_+SINEAluName=AluSz6
ADediting_222708chr10_90904580_+SINEAluName=AluSz6
ADediting_222709chr10_90904592_+SINEAluName=AluSz6
ADediting_222710chr10_90904593_+SINEAluName=AluSz6
ADediting_222711chr10_90904598_+SINEAluName=AluSz6
ADediting_222712chr10_90904603_+SINEAluName=AluSz6
ADediting_222713chr10_90904611_+SINEAluName=AluSz6
ADediting_222714chr10_90904612_+SINEAluName=AluSz6
ADediting_222715chr10_90904617_+SINEAluName=AluSz6
ADediting_222716chr10_90904626_+SINEAluName=AluSz6
ADediting_222717chr10_90904627_+SINEAluName=AluSz6
ADediting_222718chr10_90904629_+SINEAluName=AluSz6
ADediting_222719chr10_90904634_+SINEAluName=AluSz6
ADediting_222720chr10_90904635_+SINEAluName=AluSz6
ADediting_222721chr10_90904637_+SINEAluName=AluSz6
ADediting_222722chr10_90904655_+SINEAluName=AluSz6
ADediting_222723chr10_90904657_+SINEAluName=AluSz6
ADediting_222724chr10_90904660_+SINEAluName=AluSz6
ADediting_222725chr10_90904661_+SINEAluName=AluSz6
ADediting_222726chr10_90904665_+SINEAluName=AluSz6
ADediting_222727chr10_90904669_+SINEAluName=AluSz6
ADediting_222728chr10_90904686_+SINEAluName=AluSz6
ADediting_222729chr10_90904691_+SINEAluName=AluSz6
ADediting_222730chr10_90904692_+SINEAluName=AluSz6
ADediting_222731chr10_90904701_+SINEAluName=AluSz6
ADediting_222732chr10_90904718_+SINEAluName=AluSz6
ADediting_222733chr10_90904722_+SINEAluName=AluSz6
ADediting_222734chr10_90904723_+SINEAluName=AluSz6
ADediting_222735chr10_90904732_+SINEAluName=AluSz6
ADediting_222736chr10_90904733_+SINEAluName=AluSz6
ADediting_222737chr10_90904744_+SINEAluName=AluSz6
ADediting_222738chr10_90904762_+SINEAluName=AluSz6
ADediting_222739chr10_90904769_+SINEAluName=AluSz6
ADediting_222740chr10_90904797_+SINEAluName=AluSz6
ADediting_1524879chr10_90904662_+SINEAluName=AluSz6
ADediting_1524880chr10_90904724_+SINEAluName=AluSz6

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RNA A-to-I editing events in the alternative splicing sites for RPP30

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RPP30

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
boxplot
boxplot
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs