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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for IPO8 |
 Gene summary |
| Gene information | Gene symbol | IPO8 | Gene ID | 10526 |
| Gene name | importin 8 | |
| Synonyms | RANBP8 | |
| Cytomap | 12p11.21 | |
| Type of gene | protein-coding | |
| Description | importin-8RAN binding protein 8imp8ran-binding protein 8 | |
| Modification date | 20200313 | |
| UniProtAcc | O15397, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for IPO8 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_339139(30645117, -), ADediting_339140(30645261, -), ADediting_339142(30659793, -), ADediting_339143(30659846, -), ADediting_339144(30660068, -), ADediting_339145(30660136, -), ADediting_339146(30660140, -), ADediting_339147(30660161, -), ADediting_339150(30685207, -), ADediting_339151(30685208, -), ADediting_339152(30685225, -), ADediting_339153(30685304, -), ADediting_339154(30685315, -), ADediting_339155(30685316, -), ADediting_339156(30685411, -), ADediting_339157(30685680, -), ADediting_339158(30685681, -), ADediting_339159(30685708, -), ADediting_339160(30685720, -), ADediting_339161(30685803, -), ADediting_339162(30685840, -), ADediting_339163(30685841, -), ADediting_339164(30685846, -), ADediting_339165(30685851, -), ADediting_339166(30685859, -), ADediting_1532022(30659245, -), ADediting_1532023(30659425, -), ADediting_1613295(30659395, -), ADediting_1613296(30678042, -), ADediting_1613297(30678043, -), ADediting_1613298(30679004, -), ADediting_1613299(30679013, -), |
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RNA editing positional annotations for IPO8 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_339139 | chr12_30645117_- | intronic |
| ADediting_339140 | chr12_30645261_- | intronic |
| ADediting_339142 | chr12_30659793_- | intronic |
| ADediting_339143 | chr12_30659846_- | intronic |
| ADediting_339144 | chr12_30660068_- | intronic |
| ADediting_339145 | chr12_30660136_- | intronic |
| ADediting_339146 | chr12_30660140_- | intronic |
| ADediting_339147 | chr12_30660161_- | intronic |
| ADediting_339150 | chr12_30685207_- | intronic |
| ADediting_339151 | chr12_30685208_- | intronic |
| ADediting_339152 | chr12_30685225_- | intronic |
| ADediting_339153 | chr12_30685304_- | intronic |
| ADediting_339154 | chr12_30685315_- | intronic |
| ADediting_339155 | chr12_30685316_- | intronic |
| ADediting_339156 | chr12_30685411_- | intronic |
| ADediting_339157 | chr12_30685680_- | intronic |
| ADediting_339158 | chr12_30685681_- | intronic |
| ADediting_339159 | chr12_30685708_- | intronic |
| ADediting_339160 | chr12_30685720_- | intronic |
| ADediting_339161 | chr12_30685803_- | intronic |
| ADediting_339162 | chr12_30685840_- | intronic |
| ADediting_339163 | chr12_30685841_- | intronic |
| ADediting_339164 | chr12_30685846_- | intronic |
| ADediting_339165 | chr12_30685851_- | intronic |
| ADediting_339166 | chr12_30685859_- | intronic |
| ADediting_1532022 | chr12_30659245_- | intronic |
| ADediting_1532023 | chr12_30659425_- | intronic |
| ADediting_1613295 | chr12_30659395_- | intronic |
| ADediting_1613296 | chr12_30678042_- | intronic |
| ADediting_1613297 | chr12_30678043_- | intronic |
| ADediting_1613298 | chr12_30679004_- | intronic |
| ADediting_1613299 | chr12_30679013_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_339139 | chr12_30645117_- | SINE | Alu | Name=AluSx |
| ADediting_339140 | chr12_30645261_- | SINE | Alu | Name=AluSx |
| ADediting_339142 | chr12_30659793_- | SINE | Alu | Name=AluY |
| ADediting_339143 | chr12_30659846_- | SINE | Alu | Name=AluY |
| ADediting_339144 | chr12_30660068_- | SINE | Alu | Name=AluSx |
| ADediting_339145 | chr12_30660136_- | SINE | Alu | Name=AluSx |
| ADediting_339146 | chr12_30660140_- | SINE | Alu | Name=AluSx |
| ADediting_339147 | chr12_30660161_- | SINE | Alu | Name=AluSx |
| ADediting_339150 | chr12_30685207_- | SINE | Alu | Name=AluSx |
| ADediting_339151 | chr12_30685208_- | SINE | Alu | Name=AluSx |
| ADediting_339152 | chr12_30685225_- | SINE | Alu | Name=AluSx |
| ADediting_339153 | chr12_30685304_- | SINE | Alu | Name=AluSx |
| ADediting_339154 | chr12_30685315_- | SINE | Alu | Name=AluSx |
| ADediting_339155 | chr12_30685316_- | SINE | Alu | Name=AluSx |
| ADediting_339156 | chr12_30685411_- | SINE | Alu | Name=AluSx |
| ADediting_339157 | chr12_30685680_- | SINE | Alu | Name=AluSx1 |
| ADediting_339158 | chr12_30685681_- | SINE | Alu | Name=AluSx1 |
| ADediting_339159 | chr12_30685708_- | SINE | Alu | Name=AluSx1 |
| ADediting_339160 | chr12_30685720_- | SINE | Alu | Name=AluSx1 |
| ADediting_339161 | chr12_30685803_- | SINE | Alu | Name=AluSx1 |
| ADediting_339162 | chr12_30685840_- | SINE | Alu | Name=AluSx1 |
| ADediting_339163 | chr12_30685841_- | SINE | Alu | Name=AluSx1 |
| ADediting_339164 | chr12_30685846_- | SINE | Alu | Name=AluSx1 |
| ADediting_339165 | chr12_30685851_- | SINE | Alu | Name=AluSx1 |
| ADediting_339166 | chr12_30685859_- | SINE | Alu | Name=AluSx1 |
| ADediting_1532022 | chr12_30659245_- | SINE | Alu | Name=AluSx1 |
| ADediting_1532023 | chr12_30659425_- | SINE | Alu | Name=AluSx1 |
| ADediting_1613295 | chr12_30659395_- | SINE | Alu | Name=AluSx1 |
| ADediting_1613296 | chr12_30678042_- | SINE | Alu | Name=AluSx3 |
| ADediting_1613297 | chr12_30678043_- | SINE | Alu | Name=AluSx3 |
| ADediting_1613298 | chr12_30679004_- | SINE | Alu | Name=AluSx1 |
| ADediting_1613299 | chr12_30679013_- | SINE | Alu | Name=AluSx1 |
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RNA A-to-I editing events in the alternative splicing sites for IPO8 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for IPO8 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for IPO8 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for IPO8 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000133704.10 | ENST00000256079.9 | IPO8-201 | hsa-miR-337-3p | chr12 | 30629701 | 30629708 | 8mer-1a | 30629701 | 30629722 | 152 | -11.88 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000133704.10 | ENST00000256079.9 | IPO8-201 | hsa-miR-381-3p | chr12 | 30629924 | 30629930 | 7mer-m8 | 30629923 | 30629944 | 140 | -10.45 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000133704.10 | ENST00000256079.9 | IPO8-201 | hsa-miR-381-3p | chr12 | 30629924 | 30629930 | 7mer-m8 | 30629923 | 30629944 | 140 | -10.45 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000133704.10 | ENST00000535598.1 | IPO8-203 | hsa-miR-641 | chr12 | 30631719 | 30631726 | 8mer-1a | 30631719 | 30631743 | 151 | -10.82 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000133704.10 | ENST00000535598.1 | IPO8-203 | hsa-miR-641 | chr12 | 30631719 | 30631726 | 8mer-1a | 30631719 | 30631743 | 151 | -10.82 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000133704.10 | ENST00000256079.9 | IPO8-201 | hsa-miR-5682 | chr12 | 30629960 | 30629966 | 7mer-m8 | 30629959 | 30629980 | 145 | -16.42 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for IPO8 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for IPO8 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.10571334563977e-49 | 0.714391979842581 | 3.72723879713436e-33 | 0.611324068046954 | 5.63005291255912e-05 | 0.226694439555032 |
| AC | 3.35566499492635e-65 | 0.831308316222473 | 4.28768950682183e-38 | 0.699756460843025 | 7.71299625491501e-23 | 0.568899417059804 |
| PCC | 1.71052177277417e-23 | 0.641045928104402 | 6.66566713714236e-19 | 0.584676701353725 | 5.00173414279021e-06 | 0.323490223484516 |
| CER | 5.46073244641634e-44 | 0.854728655546089 | 9.86397569980218e-24 | 0.703732876664572 | 2.5141337929816e-05 | 0.336747426454849 |
| TCX | 1.44632549286199e-27 | 0.742753173465074 | 2.13256881212761e-07 | 0.408352682434081 | 5.94559879949265e-07 | 0.394330672647718 |
| FP | 9.01792764499053e-27 | 0.692708333388087 | 7.24981104301107e-33 | 0.745758572307418 | 1.27808348303387e-05 | 0.320662428587044 |
| IFG | 1.97457827408201e-06 | 0.795805080099794 | 2.32561282468141e-07 | 0.833339839948678 | 0.00119550121751024 | 0.610337432904776 |
| PG | 8.65699621175113e-51 | 0.840212539789557 | 5.09314620780765e-29 | 0.702802757103633 | 0.690095630016081 | 0.0294280063912399 |
| STG | 3.33633293670661e-11 | 0.645651213879163 | 7.0575410391033e-12 | 0.661982546644277 | 0.0412150648359895 | 0.223256173465282 |
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Relation with AD stages for IPO8 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 1.50385203287946e-05 | 0.403333267183656 |
| TCX | 3.37151554664114e-10 | 0.562908310255146 |
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RelatedDrugs for IPO8 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IPO8 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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